Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	TP73	45	2	47	129.862
#2	SRF	39	3	42	290.676
#3	TRIM29	33	6	39	293.364
#4	ZSCAN22	32	1	33	2289.011
#5	TGIF1	31	5	36	1018.052
#6	CNOT7	30	5	35	156.699
#7	HOXA1	29	1	30	27.668
#8	ZNF446	29	12	41	1979.689
#9	ZNF213	29	4	33	529.704
#10	FOXA2	29	4	33	616.733
#11	TCF25	29	6	35	1324.116
#12	CITED2	27	7	34	1021.114
#13	PLAGL2	27	5	32	342.291
#14	HESX1	27	8	35	1821.719
#15	SOX1	27	11	38	1876.58
#16	TBX19	27	6	33	2388.673
#17	ZNF71	26	2	28	15.355
#18	IRF7	26	4	30	459.609
#19	DMTF1	26	7	33	722.506
#20	NR1H4	25	10	35	839.424
#21	ZSCAN21	25	8	33	1548.255
#22	EDF1	25	10	35	551.129
#23	HOXC12	25	7	32	422.117
#24	SALL1	25	8	33	7310.633
#25	T	24	6	30	486.759
#26	ESR2	24	10	34	1874.63
#27	ZEB2	24	8	32	1850.389
#28	RORA	24	7	31	1001.379
#29	IRF9	23	2	25	54.785
#30	HMX2	23	8	31	640.019
#31	AR	23	4	27	620.93
#32	KLF4	23	8	31	389
#33	GRHL3	23	6	29	961.039
#34	MXD1	23	12	35	2450.554
#35	ZSCAN2	23	5	28	358.776
#36	HSF2	23	8	31	1970.401
#37	MYF5	22	5	27	1368.002
#38	STAT2	22	10	32	2811.964
#39	TBX21	22	12	34	1716
#40	SOX8	22	12	34	1575.454
#41	SCAND2	22	7	29	515.068
#42	ZNF134	22	10	32	745.981
#43	IRF2	22	7	29	743.614
#44	E4F1	22	10	32	1692.469
#45	ZNF18	22	13	35	2274.387
#46	SMAD2	21	5	26	103.343
#47	BACH2	21	7	28	1300.993
#48	IRX1	21	7	28	795.968
#49	PRDM2	21	6	27	359.674
#50	TSC22D4	21	9	30	922.201
#51	KLF7	21	7	28	1001.078
#52	CTCF	21	4	25	92.07
#53	MKX	21	14	35	2911.715
#54	PAX3	21	4	25	62.654
#55	TEF	21	8	29	6438.212
#56	FOXP4	21	6	27	1100.717
#57	CUX2	21	7	28	601.009
#58	SMAD3	20	11	31	1363.92
#59	FOXJ1	20	16	36	1902.959
#60	NFX1	20	7	27	902.024
#61	CBFB	20	9	29	824.571
#62	ESR1	20	11	31	2855.207
#63	HOXA10	20	17	37	1696.658
#64	ETV6	20	7	27	1332.106
#65	POU1F1	20	14	34	1409.335
#66	NFIB	20	8	28	1093.783
#67	GATA3	19	9	28	643.213
#68	MEIS3	19	15	34	1829.009
#69	FOXL2	19	12	31	871.964
#70	MLL	19	13	32	1250.314
#71	TGIF2LY	19	8	27	4049.798
#72	SREBF1	19	5	24	157.771
#73	SUPT6H	19	7	26	8642.513
#74	MEIS1	19	9	28	1074.917
#75	NR1D2	19	12	31	1475.738
#76	SIX6	19	8	27	914.841
#77	NPAT	19	9	28	1284.324
#78	ZNF37A	19	8	27	598.754
#79	GATA1	19	3	22	15.086
#80	PITX2	19	14	33	2180.676
#81	RB1	19	11	30	1130.129
#82	GATAD1	18	6	24	365.874
#83	BTG2	18	10	28	1741.151
#84	ZSCAN20	18	5	23	165.695
#85	SOX30	18	4	22	469.68
#86	ZFHX3	18	11	29	1842.168
#87	TCF20	18	11	29	1422.623
#88	POU6F1	18	6	24	188.988
#89	SATB2	18	15	33	889.459
#90	MNX1	18	17	35	2359.357
#91	MNT	18	11	29	2204.091
#92	GBX1	18	9	27	1421.398
#93	ZBTB48	18	9	27	1110.294
#94	ERG	18	12	30	2138.136
#95	ZNF189	18	9	27	3968.713
#96	RBPJ	18	18	36	2725.545
#97	ATF1	18	12	30	1666.7
#98	ETV1	18	7	25	522.333
#99	MTA1	18	8	26	830.724
#100	NFE2L1	18	8	26	382.087
#101	RUNX1	18	5	23	55.48
#102	POU3F1	18	14	32	3362.5
#103	YY1	18	14	32	1704.884
#104	POU2F1	18	16	34	1473.33
#105	HOXD1	18	13	31	1774.97
#106	JUN	17	17	34	2260.221
#107	C11orf9	17	13	30	1938.918
#108	TFAP4	17	12	29	3877.891
#109	ZNF83	17	6	23	2442.899
#110	CREM	17	9	26	555.842
#111	ZNF498	17	12	29	2397.255
#112	VDR	17	19	36	2939.013
#113	NR1I2	17	4	21	35.47
#114	EGR1	17	7	24	763.987
#115	RCAN1	17	12	29	1689.59
#116	MECOM	17	13	30	1113.557
#117	NANOG	17	13	30	2681.881
#118	HOXA5	16	6	22	727.566
#119	HOXC8	16	8	24	1123.266
#120	ARNT	16	19	35	2183.442
#121	TP53	16	14	30	1178.157
#122	MEF2D	16	12	28	871.671
#123	OTX2	16	2	18	44.276
#124	ZBTB38	16	11	27	1324.379
#125	HOXD4	16	11	27	2244.792
#126	MTF1	16	12	28	1686.116
#127	TCF7	16	11	27	973.767
#128	RHOXF2B	16	10	26	1946.178
#129	ATF7	16	7	23	1132.775
#130	ZNF69	16	11	27	556.131
#131	NKX2-3	16	7	23	779.835
#132	FOXJ2	16	9	25	1050.313
#133	PITX1	15	13	28	2344.012
#134	MEIS3P1	15	13	28	1381.4
#135	ZKSCAN3	15	17	32	1410.866
#136	PHOX2B	15	14	29	1447.794
#137	ZSCAN4	15	20	35	9236.629
#138	FEV	15	7	22	1348.351
#139	ELF1	15	10	25	1798.405
#140	PPARG	15	14	29	1205.473
#141	MESP1	15	16	31	744.663
#142	ATF6	15	13	28	2954.807
#143	MLX	15	6	21	713.241
#144	HOXB2	15	3	18	38.854
#145	ZNF174	15	16	31	1130.337
#146	C2orf3	15	9	24	791.941
#147	DBP	15	11	26	308.703
#148	ZNF138	15	8	23	709.882
#149	SNAPC5	15	6	21	617.427
#150	HES6	15	7	22	370.072
#151	AFF1	15	8	23	1394.814
#152	TFEB	15	19	34	1545.424
#153	LZTR1	15	12	27	995.263
#154	E2F4	15	15	30	3192.301
#155	KLF15	15	6	21	526.099
#156	ESRRB	15	9	24	1350.955
#157	FOXH1	15	16	31	3328.166
#158	GATA4	14	13	27	1718.488
#159	NOTCH1	14	11	25	705.376
#160	ATF2	14	12	26	1258.777
#161	ADNP2	14	14	28	5363.899
#162	ZNF154	14	6	20	2186.483
#163	ELF5	14	10	24	1336.16
#164	TRIM28	14	12	26	1021.189
#165	FOXE1	14	9	23	1017.291
#166	CDKN2A	14	8	22	1298.829
#167	MSX1	14	7	21	349.65
#168	HOXD8	14	8	22	1968.891
#169	PURB	14	11	25	1516.622
#170	DLX2	14	16	30	2555.736
#171	TFAM	14	9	23	2518.677
#172	TBX3	14	16	30	1212.672
#173	FOXN2	14	9	23	1309.974
#174	REST	14	8	22	6191.346
#175	ZKSCAN1	14	6	20	208.213
#176	ZFHX4	14	16	30	1380.351
#177	SOX10	14	12	26	337.2
#178	STAT1	14	9	23	2255.741
#179	POU5F1	14	6	20	51.783
#180	NR1D1	14	14	28	2713.397
#181	KLF3	14	17	31	1364.147
#182	ZNF323	14	17	31	1646.643
#183	SOX4	13	9	22	1034.344
#184	NR3C1	13	11	24	1190.516
#185	GTF2IRD1	13	13	26	998.689
#186	THRB	13	5	18	228.989
#187	CTBP1	13	5	18	910.986
#188	PGR	13	13	26	1248.031
#189	ZHX3	13	11	24	2356.305
#190	LBX2	13	14	27	1214.839
#191	NFIA	13	14	27	995.985
#192	RHOXF2	13	11	24	966.208
#193	MAFB	13	12	25	1023.596
#194	KLF12	13	14	27	1376.525
#195	ZNF45	13	9	22	693.941
#196	ZNF192	13	17	30	1911.869
#197	CSRNP3	13	18	31	1129.183
#198	FOXP3	13	12	25	847.948
#199	EBF1	13	9	22	1411.849
#200	NR2F2	13	16	29	2349.125
#201	RAX2	13	17	30	3025.558
#202	REXO4	13	13	26	1479.339
#203	FOXP1	13	12	25	1572.199
#204	PEG3	13	17	30	1481.055
#205	ZNF281	13	11	24	564.867
#206	ZNF367	12	12	24	1435.549
#207	TSHZ1	12	9	21	535.314
#208	GATAD2B	12	11	23	978.024
#209	FOXC1	12	9	21	1129.375
#210	ZGPAT	12	17	29	1664.236
#211	TMEM229A	12	14	26	901.643
#212	ZNF165	12	10	22	1509.189
#213	RFX3	12	7	19	135.914
#214	BARHL2	12	19	31	1645.908
#215	HCFC1	12	12	24	418.603
#216	GATA5	12	10	22	1173.655
#217	LASS5	12	13	25	1687.567
#218	HOMEZ	12	8	20	354.572
#219	GCFC1	12	10	22	638.486
#220	LHX3	12	13	25	920.064
#221	TSC22D1	12	6	18	194.219
#222	LCOR	12	7	19	640.902
#223	BACH1	12	13	25	1289.204
#224	ZNF445	12	14	26	858.622
#225	GABPB1	12	15	27	990.122
#226	SHOX	12	16	28	1781.813
#227	HIF3A	12	10	22	7061.252
#228	MYF6	12	20	32	1708.601
#229	JUND	12	13	25	1448.234
#230	ZKSCAN2	12	17	29	1284.098
#231	TP63	12	14	26	1631.681
#232	RBCK1	12	17	29	1540.637
#233	HMG20B	12	12	24	839.482
#234	TCEAL1	12	19	31	1875.299
#235	RFX5	12	17	29	1021.964
#236	GTF2H3	11	13	24	1761.881
#237	EMX1	11	18	29	797.272
#238	SIN3A	11	11	22	576.8
#239	SCML1	11	18	29	1618.45
#240	NKX2-1	11	20	31	1573.632
#241	CUX1	11	22	33	1473.543
#242	E2F1	11	8	19	516.478
#243	SCRT2	11	13	24	1341.971
#244	BNC1	11	12	23	983.99
#245	TRIM22	11	9	20	922.694
#246	ETS1	11	6	17	1429.568
#247	TCFL5	11	13	24	926.975
#248	ELK1	11	16	27	1367.614
#249	CREBL2	11	9	20	267.026
#250	STAT5B	11	12	23	960.653
#251	HOXA6	11	12	23	7704.206
#252	E2F2	11	8	19	810.574
#253	HNRNPK	11	7	18	5366.018
#254	C12orf28	11	9	20	698.236
#255	ZNF91	11	5	16	263.936
#256	RXRA	11	17	28	881.784
#257	HMGA2	11	12	23	1345.755
#258	GTF2I	11	10	21	140.407
#259	ZNF219	11	17	28	1257.942
#260	HNF1A	11	22	33	1877.063
#261	TBP	10	18	28	1975.367
#262	RELB	10	10	20	967.607
#263	SCRT1	10	12	22	2197.661
#264	MSC	10	14	24	904.589
#265	MGA	10	11	21	1169.373
#266	IRF6	10	15	25	1968.137
#267	ST18	10	15	25	962.401
#268	RERE	10	16	26	1591.881
#269	DLX6	10	11	21	1768.72
#270	POU2F3	10	17	27	1048.142
#271	ZNF263	10	12	22	999.28
#272	LASS2	10	15	25	1527.516
#273	ZNF93	10	15	25	1705.691
#274	MSRB2	10	11	21	840.3
#275	UHRF1	10	12	22	906.58
#276	ZFPM2	10	6	16	3297.091
#277	GABPA	10	5	15	629.964
#278	HINFP	10	21	31	2044.026
#279	TCF4	10	15	25	1600.233
#280	HOXA2	10	15	25	2611.029
#281	FOS	10	10	20	420.273
#282	HES1	10	19	29	1373.608
#283	TLX2	10	13	23	1220.907
#284	KLF2	10	18	28	1475.673
#285	PBX1	10	14	24	1697.859
#286	ETV3L	10	16	26	1321.307
#287	EN1	10	10	20	1042.802
#288	ELF4	10	6	16	1219.826
#289	FOXR1	10	10	20	1560.323
#290	TCF21	10	18	28	1040.117
#291	BATF3	10	4	14	346.671
#292	NEUROD1	9	14	23	1115.749
#293	HOXD10	9	7	16	491.328
#294	BTAF1	9	14	23	1316.561
#295	TCF12	9	14	23	1364.254
#296	FOXA1	9	21	30	1726.396
#297	E2F5	9	9	18	808.117
#298	PA2G4	9	13	22	605.872
#299	SNAI3	9	13	22	2530.104
#300	SMAD6	9	17	26	2113.88
#301	TARDBP	9	10	19	881.168
#302	EVX1	9	11	20	1041.942
#303	IRX4	9	8	17	326.311
#304	L3MBTL4	9	11	20	484.172
#305	ZNF394	9	11	20	482.392
#306	SRY	9	6	15	99.544
#307	IKZF1	9	15	24	892.438
#308	ZNF483	9	12	21	444.27
#309	HIRA	9	9	18	453.297
#310	GATA2	9	18	27	1918.432
#311	ZNF92	9	14	23	3561.079
#312	ZRANB2	9	16	25	734.675
#313	KLF6	9	12	21	1011.075
#314	CREB1	9	12	21	289.583
#315	FOXC2	9	10	19	674.133
#316	TEAD3	9	9	18	529.593
#317	JDP2	9	14	23	649.908
#318	HNF4G	9	16	25	1501.189
#319	ZNF207	9	14	23	1661.749
#320	SUPT4H1	9	10	19	394.718
#321	HOXC6	9	12	21	504.41
#322	DLX1	9	12	21	1544.945
#323	PBX3	9	13	22	855.514
#324	ZXDA	9	11	20	2996.164
#325	TFCP2	9	21	30	2349.488
#326	AEBP1	9	11	20	1536.384
#327	BUD31	9	11	20	1992.43
#328	EHF	9	10	19	173.008
#329	SNAPC4	9	11	20	798.495
#330	CITED1	9	12	21	1191.835
#331	IRX6	8	7	15	6874.006
#332	JUNB	8	19	27	1361.819
#333	PHF5A	8	13	21	1341.657
#334	ONECUT2	8	13	21	1496.698
#335	FOXL1	8	17	25	1055.286
#336	CTNNB1	8	13	21	809.101
#337	SOLH	8	15	23	832.429
#338	ZSCAN18	8	14	22	771.628
#339	SMAD4	8	15	23	744.09
#340	KLF5	8	17	25	1479.125
#341	MAFK	8	9	17	682.405
#342	TBR1	8	19	27	995.863
#343	NEUROD2	8	16	24	985.877
#344	MEF2A	8	11	19	591.73
#345	FOXO3	8	20	28	986.659
#346	SOX11	8	15	23	935.461
#347	CREBBP	8	21	29	1230.764
#348	HIF1A	8	17	25	1685.379
#349	NME2	8	13	21	664.237
#350	SMAD1	8	20	28	1278.958
#351	NFE2	8	11	19	491.48
#352	ZNF33A	8	15	23	937.713
#353	CNBP	8	10	18	689.699
#354	ZIC1	8	16	24	1255.939
#355	PKNOX2	8	19	27	1277.793
#356	RORB	8	15	23	980.971
#357	SOX12	8	12	20	830.139
#358	CBFA2T2	8	13	21	607.403
#359	RFXANK	8	12	20	3718.616
#360	ZNF75D	8	25	33	950.148
#361	TFE3	8	12	20	496.147
#362	ECSIT	8	10	18	495.266
#363	BRD8	8	14	22	535.035
#364	ATF6B	8	14	22	465.688
#365	GTF2H4	8	11	19	691.902
#366	NFATC1	8	16	24	1185.292
#367	CREB3L1	8	16	24	624.252
#368	CBL	8	11	19	597.718
#369	ZNF236	7	19	26	1476.478
#370	BLZF1	7	8	15	375.177
#371	ZNF397	7	13	20	257.755
#372	ZFHX2	7	12	19	652.85
#373	NFAT5	7	12	19	511.592
#374	MYC	7	19	26	491.885
#375	ATF4	7	18	25	852.088
#376	YBX1	7	14	21	783.002
#377	YEATS4	7	18	25	1265.516
#378	NR2E1	7	12	19	1438.669
#379	HOXC11	7	16	23	3288.7
#380	CREB3	7	8	15	399.773
#381	SP3	7	14	21	899.963
#382	NANOGP1	7	17	24	827.048
#383	KLF10	7	8	15	593.43
#384	NPAS2	7	12	19	1472.197
#385	KDM5B	7	9	16	168.603
#386	HMGB2	7	14	21	734.615
#387	MYCN	7	16	23	325.05
#388	SIX4	7	7	14	513.46
#389	ETV5	7	18	25	862.896
#390	THRA	7	17	24	1273.069
#391	SCAND3	7	8	15	5635.776
#392	ARID4A	7	15	22	703.973
#393	MSL3	7	19	26	936.963
#394	IRF5	7	9	16	378.328
#395	SP1	7	12	19	785.206
#396	PLSCR1	7	10	17	769.622
#397	TSHZ3	7	7	14	194.704
#398	ZNF167	7	10	17	897.12
#399	GATAD2A	7	13	20	668.133
#400	POU4F3	7	19	26	915.79
#401	TAF1B	7	19	26	963.949
#402	STAT5A	7	17	24	405.927
#403	ZNF217	7	15	22	762.626
#404	HNF1B	7	8	15	346.092
#405	TFAP2B	7	16	23	912.4
#406	POU3F3	7	15	22	1986.769
#407	HSF4	7	10	17	543.316
#408	NPAS1	7	12	19	507.137
#409	MYOG	6	12	18	553.736
#410	MAF	6	13	19	1151.837
#411	FBXW7	6	7	13	136.062
#412	HDAC1	6	9	15	94.806
#413	PURA	6	10	16	464.917
#414	NFKB1	6	15	21	759.973
#415	CEBPB	6	17	23	322.743
#416	PKNOX1	6	12	18	507.893
#417	FOXQ1	6	14	20	312.697
#418	STAT4	6	13	19	482.338
#419	SP140	6	16	22	1125.282
#420	RORC	6	10	16	357.485
#421	UBP1	6	16	22	940.491
#422	RELA	6	10	16	6294.3
#423	NFATC3	6	10	16	1066.036
#424	ZNF274	6	17	23	1133.148
#425	ZFP42	6	18	24	585.075
#426	USF2	6	15	21	396.147
#427	EGR2	6	9	15	243.794
#428	PPARA	6	16	22	826.12
#429	ZKSCAN5	6	12	18	809.813
#430	NFYB	5	10	15	379.038
#431	FOXK1	5	13	18	367.8
#432	VAX2	5	14	19	993.037
#433	MLLT10	5	9	14	179.634
#434	IKZF3	5	17	22	2073.216
#435	HOXB4	5	20	25	841.627
#436	HOPX	5	13	18	1482.105
#437	FOSL2	5	9	14	665.644
#438	TBX22	5	15	20	809.432
#439	GRHL2	5	10	15	424.225
#440	CREB3L2	5	11	16	489.832
#441	HDX	5	15	20	1150.283
#442	CNOT8	5	14	19	515.669
#443	PPARD	5	10	15	633.743
#444	STAT3	5	17	22	587.334
#445	SOX6	5	18	23	515.634
#446	PROX1	5	17	22	822.903
#447	AFF4	5	18	23	501.789
#448	TFAP2A	5	16	21	609.934
#449	TULP4	5	9	14	469.869
#450	TCF19	5	22	27	968.341
#451	RFX1	5	16	21	2181.345
#452	ZNF24	5	13	18	306.355
#453	TFDP1	5	16	21	499.231
#454	ZSCAN16	5	10	15	284.136
#455	SOX5	4	12	16	579.468
#456	HMGB1	4	21	25	2543.631
#457	LMX1A	4	13	17	335.485
#458	RUNX2	4	18	22	1222.023
#459	HCLS1	4	18	22	809.013
#460	HOXB1	4	19	23	622.995
#461	ZNF396	4	18	22	2207.236
#462	NR1I3	4	14	18	975.063
#463	STRN3	4	14	18	1019.581
#464	MTA3	4	22	26	1239.696
#465	E2F6	4	19	23	586.876
#466	NFKB2	4	14	18	734.061
#467	PHOX2A	4	15	19	553.01
#468	ZNF135	4	18	22	774.812
#469	TAF7	4	17	21	541.866
#470	OVOL1	4	16	20	672.702
#471	SOX15	4	13	17	226.319
#472	ZNF157	4	14	18	481.47
#473	POU2F2	4	15	19	567.52
#474	PBX2	4	11	15	318.425
#475	ZNF155	4	15	19	361.754
#476	IRX3	4	14	18	274.186
#477	TBX5	4	18	22	793.913
#478	NFIC	4	19	23	404.514
#479	ZNF215	4	12	16	451.165
#480	ZIC5	3	25	28	1767.121
#481	ZXDC	3	16	19	1274.322
#482	ARID3A	3	14	17	287.132
#483	GLIS3	3	14	17	215.779
#484	MZF1	3	18	21	325.855
#485	ESRRA	3	13	16	247.308
#486	ZSCAN29	3	14	17	307.261
#487	SPEN	3	15	18	1346.734
#488	TADA2A	3	12	15	337.428
#489	TSC22D2	3	17	20	629.535
#490	SPDEF	2	18	20	314.789
#491	TCF7L2	2	15	17	514.236
#492	E2F3	2	20	22	169.748
#493	TRERF1	1	19	20	187.095
#494	ESRRG	1	13	14	281.098
#495	MAFG	1	13	14	37.895
#496	TWIST1	1	19	20	78.862
#497	ZNF187	1	17	18	280.727
#498	CSRNP2	1	13	14	230.691
#499	FOXN3	1	17	18	131.692
#500	FOXF1	1	14	15	547.238