Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	TEF	59	7	66	14489.594
#2	STAT6	57	11	68	3093.012
#3	C1orf85	49	4	53	647.94
#4	PHF5A	48	4	52	168.592
#5	HEYL	46	8	54	1931.454
#6	TCF7L2	43	6	49	752.241
#7	BTG2	43	5	48	1256.503
#8	PBX1	42	6	48	1133.899
#9	NR1D2	42	4	46	1932.155
#10	ZFHX2	40	10	50	680.035
#11	AHCTF1	40	5	45	766.435
#12	CCRN4L	40	2	42	85.591
#13	ESR1	39	10	49	3575.73
#14	ZFP42	38	4	42	544.012
#15	ETV4	38	1	39	205.155
#16	TBX1	35	11	46	1992.279
#17	TFDP2	35	1	36	839.553
#18	SPDEF	35	16	51	4658.197
#19	FOXP1	34	13	47	1119.26
#20	MYOG	33	7	40	1684.644
#21	TCF21	32	8	40	1067.825
#22	ETS2	32	7	39	1492.867
#23	CREB3L3	31	7	38	2015.037
#24	PBX3	31	4	35	1993.675
#25	NKX6-1	31	10	41	1291.063
#26	SOX17	31	8	39	2333.098
#27	HCLS1	31	11	42	1679.118
#28	ADNP2	29	10	39	963.018
#29	DDIT3	29	4	33	236.675
#30	KDM5B	28	16	44	1195.103
#31	STAT3	28	5	33	1197.911
#32	ESR2	28	13	41	1099.38
#33	NRL	28	10	38	4231.04
#34	ONECUT2	28	7	35	3982.758
#35	HOXB6	28	9	37	1512.202
#36	BLZF1	27	14	41	1027.165
#37	EOMES	27	3	30	351.085
#38	MXD1	27	12	39	599.984
#39	TRIM25	26	10	36	919.568
#40	SREBF1	26	5	31	534.866
#41	TEAD1	26	9	35	3826.143
#42	HINFP	26	14	40	5241.183
#43	IKZF4	26	8	34	923.864
#44	ASCL2	26	11	37	890.875
#45	AFF4	26	13	39	590.225
#46	DLX1	25	11	36	794.222
#47	DMTF1	25	9	34	880.994
#48	FLI1	25	9	34	1050.815
#49	GATA4	25	9	34	2052.35
#50	EMX1	25	7	32	1053.896
#51	FOXE1	25	9	34	857.937
#52	PITX1	25	9	34	541.769
#53	FOXP2	25	13	38	1052.08
#54	NEUROD1	25	14	39	934.855
#55	C5orf41	24	12	36	1301.905
#56	ALX4	24	4	28	258.185
#57	RB1	24	11	35	2322.202
#58	ATOH1	24	7	31	183.87
#59	OTX1	24	12	36	2317.768
#60	ARNT2	23	9	32	283.725
#61	MYC	23	11	34	1259.686
#62	PKNOX2	23	9	32	463.735
#63	SMAD9	23	15	38	2055.495
#64	NKX1-2	23	9	32	1232.727
#65	SP4	23	5	28	271.813
#66	ZNF189	22	7	29	668.764
#67	AFF1	22	14	36	3680.329
#68	REST	22	7	29	1134.924
#69	GRHL3	22	9	31	631.409
#70	LMX1B	22	4	26	351.241
#71	PHTF1	22	14	36	3338.656
#72	TFE3	22	9	31	552.858
#73	HOXA9	22	14	36	3119.468
#74	BATF2	22	4	26	502.712
#75	TP53	22	8	30	470.793
#76	CTBP1	22	11	33	1694.038
#77	TBP	21	18	39	1913.464
#78	SOX8	21	7	28	855.49
#79	CTCF	21	8	29	777.97
#80	ZSCAN29	21	15	36	1243.141
#81	ZNF33A	21	7	28	4668.107
#82	ZNF187	21	11	32	1050.712
#83	FOXD1	21	12	33	1159.808
#84	SMAD5	21	10	31	1056.935
#85	ZNF438	21	13	34	591.08
#86	MMP14	21	4	25	652.738
#87	MYBL2	21	3	24	269.729
#88	SP1	21	16	37	1106.026
#89	NOTCH1	20	16	36	1146.804
#90	ZNF263	20	10	30	1481.913
#91	TFAP2E	20	13	33	847.508
#92	ZNF148	20	11	31	1153.133
#93	C11orf9	20	14	34	1103.308
#94	STAT2	20	12	32	1733.463
#95	SNAPC4	20	7	27	579.321
#96	RUNX2	20	7	27	800.743
#97	HOXB7	20	15	35	1176.796
#98	TPRX1	20	12	32	2103.981
#99	FOXI1	20	2	22	98.242
#100	HOXB5	20	11	31	962.125
#101	NR2F1	20	9	29	3508.44
#102	ZBTB48	20	12	32	1656.739
#103	ZNF444	20	9	29	5722.292
#104	PURB	19	2	21	25.889
#105	AEBP1	19	17	36	5194.652
#106	ETV3	19	11	30	242.406
#107	LASS5	19	8	27	909.574
#108	SOX4	19	12	31	1223.896
#109	TSHZ3	19	14	33	2398.712
#110	ZNF140	19	9	28	815.987
#111	IRF5	19	8	27	1654.694
#112	EVX1	19	15	34	2414.564
#113	NR2E3	18	6	24	505.337
#114	MLX	18	15	33	2429.758
#115	NFX1	18	13	31	3785.293
#116	TMEM229A	18	3	21	286.522
#117	OLIG2	18	23	41	2875.621
#118	THRA	18	7	25	542.525
#119	TAF4	18	13	31	2438.978
#120	SCAND3	18	5	23	480.347
#121	ZNF219	18	6	24	477.129
#122	NFATC4	18	6	24	2414.004
#123	CREBZF	18	5	23	100.795
#124	SP140	18	13	31	3213.974
#125	ATF6	18	8	26	1703.496
#126	FBXW7	18	18	36	1046.204
#127	RCOR2	18	12	30	3286.161
#128	AR	18	12	30	830.386
#129	CNOT7	18	6	24	109.829
#130	RUNX1	17	10	27	618.738
#131	ZNF236	17	3	20	92.46
#132	MEOX2	17	2	19	166.086
#133	ZNF445	17	12	29	491.571
#134	HOXC6	17	10	27	1003.628
#135	RXRA	17	15	32	1504.951
#136	HOXA4	17	13	30	1012.707
#137	EN2	17	9	26	1846.278
#138	TLX2	17	7	24	92.584
#139	MAF	17	7	24	533.254
#140	ESRRA	17	8	25	225.924
#141	NFATC2	17	7	24	1320.553
#142	FOXP3	17	14	31	1141.553
#143	ATF2	17	17	34	2055.865
#144	ZNF232	17	10	27	677.864
#145	NFKB2	16	8	24	213.87
#146	HOXD13	16	18	34	1037.161
#147	FOXQ1	16	3	19	85.168
#148	NKX2-3	16	6	22	438.175
#149	RBPJ	16	18	34	20123.533
#150	PPARG	16	14	30	1702.738
#151	ERF	16	10	26	1691.761
#152	TLX3	16	5	21	734.372
#153	ZSCAN18	16	15	31	755.259
#154	HIF3A	16	7	23	407.23
#155	MITF	16	14	30	744.121
#156	LHX6	16	15	31	3170.239
#157	FOXM1	16	13	29	737.608
#158	ZNF202	16	10	26	1148.121
#159	HOXD9	16	15	31	1545.037
#160	MYT1	16	13	29	1103.053
#161	GTF2I	16	11	27	496.697
#162	PGR	16	13	29	3635.158
#163	HOXC8	15	11	26	325.771
#164	NR2C1	15	9	24	1733.831
#165	CREB3L1	15	23	38	8358.486
#166	VTN	15	7	22	938.368
#167	ELF5	15	12	27	1028.988
#168	GATA2	15	14	29	883.55
#169	EGR1	15	22	37	4616.13
#170	TCF7L1	15	18	33	1684.169
#171	TCF3	15	16	31	1288.745
#172	FOSB	15	13	28	1324.7
#173	TRIM28	15	18	33	2502.145
#174	SCAND2	15	15	30	737.668
#175	E2F8	15	16	31	2039.72
#176	IRX3	15	21	36	1468.628
#177	BTAF1	15	9	24	488.792
#178	HSF2	15	17	32	2039.61
#179	FOXA3	15	13	28	642.915
#180	ZNF643	15	9	24	1038.327
#181	EHF	15	20	35	1448.395
#182	TWIST1	14	15	29	1094.645
#183	MEIS3P1	14	20	34	1801.995
#184	SOX5	14	8	22	944.154
#185	TBX5	14	4	18	46.911
#186	IRX4	14	2	16	499.481
#187	RELB	14	15	29	586.842
#188	HNF4A	14	16	30	3286.628
#189	PHF1	14	4	18	501.56
#190	LMO4	14	13	27	2972.669
#191	NR0B1	14	21	35	1022.642
#192	VDR	14	14	28	1744.079
#193	E2F2	14	11	25	580.811
#194	TSC22D3	14	14	28	838.899
#195	NR1H2	14	14	28	1005.75
#196	ASCL1	14	18	32	527.673
#197	ATF3	14	6	20	404.154
#198	KLF15	14	16	30	3145.163
#199	CDKN2A	13	7	20	305.254
#200	NFIX	13	10	23	578.754
#201	LHX1	13	14	27	2790.517
#202	SOX9	13	9	22	1470.523
#203	ZNF175	13	15	28	342.225
#204	MLLT10	13	11	24	635.755
#205	TCF7	13	13	26	605.576
#206	FOXO4	13	15	28	1071.606
#207	CNOT8	13	14	27	1013.643
#208	CREBBP	13	7	20	359.411
#209	ZKSCAN2	13	14	27	1223.617
#210	TSC22D2	13	9	22	683.859
#211	RFXANK	13	19	32	3207.213
#212	FUBP1	13	11	24	348.279
#213	ZNF500	13	10	23	725.062
#214	PTH	13	9	22	1269.974
#215	PROX1	13	17	30	1104.957
#216	MAFK	13	12	25	978.757
#217	ZSCAN20	13	14	27	2461.159
#218	RBPJL	13	20	33	1129.884
#219	ZNF37A	13	10	23	1064.764
#220	MEF2D	13	9	22	3140.492
#221	MYT1L	13	15	28	532.906
#222	HNF1A	13	12	25	817.611
#223	SRF	12	8	20	284.475
#224	ZXDA	12	13	25	700.685
#225	TARDBP	12	15	27	754.122
#226	ARNT	12	14	26	1021.959
#227	RCOR1	12	13	25	1108.778
#228	ZNF131	12	19	31	1414.473
#229	HESX1	12	17	29	1253.178
#230	ZNF45	12	17	29	1105.399
#231	MBD1	12	5	17	446.816
#232	VAX2	12	3	15	258.645
#233	SOLH	12	16	28	1519.289
#234	PLAGL2	12	21	33	1755.299
#235	TAL1	12	23	35	1742.505
#236	KLF12	12	8	20	481.489
#237	CSDA	12	10	22	2094.556
#238	ZNF19	12	10	22	397.152
#239	MECOM	12	6	18	148.718
#240	BCL3	12	15	27	394.056
#241	MEOX1	11	11	22	727.914
#242	RARA	11	12	23	576.125
#243	HOXA7	11	7	18	275.929
#244	EGR2	11	15	26	1212.935
#245	ZIC5	11	13	24	2021.919
#246	KCNH8	11	19	30	541.305
#247	ZKSCAN1	11	19	30	740.636
#248	NOLC1	11	8	19	520.026
#249	ZNF134	11	19	30	1949.762
#250	CUX1	11	21	32	1699.754
#251	HDAC1	11	17	28	2180.322
#252	MYCN	11	13	24	904.866
#253	TRERF1	11	17	28	1675.562
#254	CREB3L2	11	19	30	2978.746
#255	ZEB2	11	5	16	109.63
#256	ESX1	11	12	23	1157.815
#257	ZSCAN12	11	18	29	2906.155
#258	TFAP2A	11	21	32	1992.427
#259	GATAD2A	11	23	34	1624.673
#260	ZNF24	11	22	33	807.792
#261	CREM	11	15	26	402.556
#262	HIF1A	11	19	30	1373.416
#263	UBN1	11	17	28	1474.336
#264	PFDN1	11	14	25	380.476
#265	NFAT5	11	6	17	72.347
#266	FOXL1	11	12	23	879.973
#267	PRDM1	11	12	23	1039.751
#268	ZFHX4	11	11	22	873.588
#269	JUNB	11	13	24	391.228
#270	RHOXF2B	11	14	25	858.366
#271	NR4A3	11	13	24	1532.462
#272	FOXA1	11	2	13	54.614
#273	L3MBTL4	11	9	20	478.477
#274	NFKB1	11	10	21	2433.119
#275	RARG	10	8	18	177.396
#276	FOXI3	10	18	28	867.13
#277	CITED1	10	4	14	156.441
#278	TBX6	10	23	33	5376.688
#279	LMX1A	10	4	14	82.357
#280	SUPT6H	10	11	21	288.518
#281	ZIC1	10	9	19	330.863
#282	SPIB	10	12	22	430.663
#283	HIC1	10	13	23	528.46
#284	NFE2L1	10	16	26	1689.253
#285	ZFP36L1	10	11	21	842.028
#286	HMGB1	10	11	21	645.363
#287	SUPT4H1	10	19	29	1076.367
#288	JUN	10	15	25	1255.225
#289	FOXJ1	10	8	18	224.066
#290	MEIS1	10	12	22	275.239
#291	ALX1	10	22	32	3358.365
#292	ATF7	10	17	27	2070.896
#293	SIN3A	10	17	27	1555.477
#294	NPAS2	10	12	22	1024.089
#295	WNT5A	10	13	23	507.625
#296	YY1	10	18	28	840.805
#297	DMRT1	10	13	23	1380.073
#298	ARX	10	12	22	519.769
#299	SOX30	10	17	27	1150.057
#300	ANKRD30A	10	19	29	700.242
#301	CREB3L4	10	14	24	782.958
#302	NFE2L2	10	19	29	1149.84
#303	ETV7	10	16	26	1495.085
#304	POU3F3	10	10	20	624.915
#305	NANOG	10	17	27	840.743
#306	ZKSCAN4	9	8	17	190.115
#307	CTNNB1	9	15	24	954.422
#308	FOXJ3	9	17	26	6462.098
#309	SIX6	9	11	20	587.713
#310	HOXC4	9	18	27	798.064
#311	ETV6	9	17	26	461.725
#312	PRRX1	9	20	29	4506.849
#313	NFE2L3	9	14	23	1039.205
#314	HOXA10	9	15	24	431.858
#315	TCF20	9	17	26	1751.377
#316	UHRF1	9	23	32	1499.942
#317	FOXD3	9	13	22	1483.768
#318	E4F1	9	16	25	938.694
#319	ERG	9	16	25	688.354
#320	POU3F1	9	10	19	362.47
#321	ZC3H8	9	18	27	774.594
#322	ZBTB38	9	17	26	1491.458
#323	THRB	9	22	31	1626.782
#324	TP63	9	13	22	589.073
#325	LZTR1	9	18	27	755.689
#326	ZFPM2	9	18	27	889.6
#327	E2F1	9	3	12	65.005
#328	TSC22D1	9	16	25	3573.172
#329	CREB1	9	2	11	65.902
#330	PKNOX1	9	22	31	460.959
#331	HAND2	9	10	19	332.911
#332	POU3F2	9	19	28	1067.603
#333	POU4F2	9	16	25	2175.758
#334	FOSL1	9	19	28	1650.081
#335	RAX	9	11	20	571.226
#336	KLF3	9	19	28	969.858
#337	NR1D1	9	14	23	315.348
#338	TFDP1	9	17	26	1094.74
#339	SMAD2	8	4	12	78.204
#340	POU5F2	8	18	26	657.839
#341	NFYC	8	3	11	96.808
#342	NFIB	8	18	26	1341.5
#343	POU3F4	8	10	18	183.582
#344	ELK4	8	20	28	853.422
#345	MTA3	8	13	21	918.428
#346	LHX4	8	16	24	477.469
#347	DRAP1	8	14	22	844.067
#348	ZNF85	8	13	21	732.135
#349	ESRRB	8	27	35	2164.485
#350	SOX10	8	9	17	1309.007
#351	PAX3	8	18	26	1157.8
#352	YEATS4	8	5	13	60.241
#353	PPARD	8	4	12	110.563
#354	SIM2	8	19	27	578.32
#355	POU6F2	8	16	24	531.37
#356	LHX9	8	19	27	642.613
#357	LHX2	8	14	22	859.846
#358	HNRNPK	8	13	21	384.672
#359	CSRNP3	8	11	19	584.535
#360	MYPOP	8	18	26	907.939
#361	NCOR1	8	22	30	2416.263
#362	MEIS3	8	12	20	439.879
#363	FOXG1	8	17	25	978.463
#364	E2F6	8	9	17	300.184
#365	ELK3	8	25	33	2615.381
#366	NFE2	8	14	22	357.888
#367	STAT5B	8	17	25	1194.491
#368	TEAD3	8	4	12	207.481
#369	ZNF397	8	26	34	1679.352
#370	GTF2H3	7	23	30	1752.877
#371	ZNF35	7	16	23	447.615
#372	RELA	7	8	15	54.259
#373	MAX	7	16	23	2658.937
#374	HCFC1	7	11	18	651.646
#375	ZNF256	7	19	26	801.603
#376	NR4A2	7	22	29	902.781
#377	JDP2	7	25	32	857.041
#378	VENTX	7	7	14	257.589
#379	ATF4	7	30	37	4419.949
#380	HMG20A	7	20	27	454.072
#381	ZNF639	7	12	19	942.835
#382	ZNF174	7	15	22	2435.439
#383	NFYA	7	15	22	507.692
#384	ST18	7	11	18	728.379
#385	SMAD4	7	16	23	340.496
#386	SIX4	7	10	17	122.129
#387	SOX2	7	17	24	464.429
#388	ARNTL2	7	11	18	594.706
#389	MSX2	7	8	15	681.717
#390	EN1	7	22	29	1692.526
#391	GLIS3	7	21	28	1629.935
#392	NR5A2	7	5	12	19.559
#393	KLF16	6	18	24	1617.124
#394	DLX3	6	19	25	433.862
#395	MTA1	6	17	23	515.48
#396	FOXD2	6	24	30	514.338
#397	BARX1	6	9	15	214.756
#398	ZNF483	6	7	13	263.307
#399	TBX19	6	20	26	1160.315
#400	IRF4	6	19	25	773.811
#401	SMAD3	6	8	14	3092.934
#402	ZNF193	6	20	26	814.61
#403	MNT	6	18	24	842.509
#404	SMAD1	6	18	24	639.69
#405	PAX8	6	21	27	1200.969
#406	ARNTL	6	18	24	1847.426
#407	XBP1	6	20	26	1937.698
#408	TSHZ2	6	20	26	2169.452
#409	ATF5	6	10	16	548.519
#410	BACH2	6	6	12	138.817
#411	BRD8	6	27	33	978.837
#412	DLX2	5	16	21	443.434
#413	NFIA	5	20	25	973.83
#414	ZRANB2	5	16	21	223.784
#415	HMGA2	5	21	26	401.398
#416	TFAM	5	22	27	1301.284
#417	SATB2	5	19	24	1762.956
#418	ZNF207	5	14	19	523.273
#419	CEBPB	5	7	12	104.903
#420	SOX6	5	15	20	232.672
#421	STRN3	5	12	17	885.407
#422	SOX7	5	19	24	1927.611
#423	ZNF75D	5	16	21	795.568
#424	HOPX	5	19	24	864.763
#425	ATF6B	5	21	26	611.534
#426	FOXN3	5	8	13	33.734
#427	ZNF167	5	24	29	591.488
#428	ZNF70	5	16	21	932.57
#429	E2F4	5	19	24	1513.54
#430	ZNF135	5	15	20	244.124
#431	KLF6	5	13	18	1386.274
#432	RORC	5	22	27	1020.501
#433	SALL2	5	19	24	971.047
#434	PAX5	5	18	23	198.544
#435	FOXC1	5	16	21	1620.144
#436	MLXIPL	5	18	23	321.212
#437	ELF1	4	21	25	4485.867
#438	TRIM29	4	20	24	568.763
#439	ELK1	4	22	26	396.545
#440	BARHL1	4	15	19	234.185
#441	ZNF213	4	15	19	192.368
#442	NFYB	4	11	15	201.086
#443	FOXK1	4	23	27	1386.225
#444	TFCP2	4	21	25	582.977
#445	GSC2	4	17	21	131.518
#446	ZNF117	4	7	11	114.016
#447	SIX1	4	18	22	293.853
#448	CEBPA	4	24	28	1164.878
#449	RNF4	4	19	23	1090.537
#450	HNF1B	4	15	19	477.834
#451	KLF7	4	24	28	676.599
#452	HMBOX1	4	20	24	787.334
#453	IKZF1	4	18	22	217.465
#454	TCF4	4	26	30	690.14
#455	GABPB1	4	24	28	373.302
#456	SIX3	4	16	20	300.685
#457	ZSCAN2	3	21	24	520.024
#458	MTF1	3	12	15	223.327
#459	FOXJ2	3	20	23	954.623
#460	ZFPM1	3	17	20	836.061
#461	MLL	3	20	23	231.804
#462	HOXB3	3	17	20	242.81
#463	TFEC	3	19	22	637.024
#464	FOXA2	3	20	23	225.529
#465	FOXR1	3	17	20	105.399
#466	TEAD2	3	8	11	194.918
#467	CBFB	3	12	15	81.982
#468	BATF3	3	18	21	232.785
#469	TCF19	3	9	12	141.33
#470	HR	3	24	27	529.068
#471	NR3C1	3	8	11	43.373
#472	VSX1	3	16	19	595.479
#473	FOXN4	3	8	11	107.095
#474	RERE	3	20	23	474.095
#475	ZBTB25	3	21	24	387.082
#476	IRX5	3	12	15	207.703
#477	HOXA11	3	21	24	3196.89
#478	TCFL5	3	24	27	272.871
#479	PPARA	2	19	21	628.418
#480	STAT1	2	11	13	405.226
#481	HES6	2	14	16	61.599
#482	MGA	2	13	15	118.252
#483	ZHX2	2	23	25	176.387
#484	HMGA1	2	18	20	963.84
#485	TBX3	2	25	27	581.779
#486	RUNX1T1	2	22	24	620.152
#487	RORA	2	14	16	258.833
#488	IRF3	2	16	18	44.894
#489	TP73	2	22	24	340.302
#490	CITED2	2	19	21	239.453
#491	SOX11	2	24	26	94.351
#492	PAX6	1	24	25	1851.124
#493	LCOR	1	22	23	60.51
#494	GLI2	1	11	12	33.438
#495	NFATC3	1	18	19	36.02
#496	STAT5A	1	12	13	2061.029
#497	SNAPC5	1	21	22	519.551
#498	GRHL2	1	20	21	76.834
#499	IRX2	0	30	30	0
#500	POU5F1	0	14	14	0