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Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	PLSCR1	42	2	44	4491.615
#2	EVX1	37	1	38	309.483
#3	SCML2	31	2	33	366.118
#4	WNT5A	30	1	31	92.53
#5	RXRG	27	0	27	0
#6	TSC22D1	25	5	30	7017.487
#7	HDAC2	25	2	27	79.656
#8	KLF1	25	2	27	114.964
#9	ADNP	24	5	29	1043.583
#10	FOXG1	23	4	27	4343.765
#11	PAX8	23	2	25	59.375
#12	TCFL5	23	6	29	2656.566
#13	SOX2	23	4	27	2649.444
#14	TFAM	23	7	30	4502.524
#15	CTCF	22	3	25	149.689
#16	ZNF238	21	5	26	1831.766
#17	MEF2A	21	6	27	52462.942
#18	TLX2	21	2	23	142.919
#19	MEOX2	21	8	29	7504.473
#20	MYCL1	20	3	23	204.362
#21	SMAD4	20	6	26	6164.174
#22	HINFP	20	5	25	2755.063
#23	HDAC1	19	4	23	886.777
#24	PURA	19	5	24	1881.213
#25	ATF2	19	2	21	594.951
#26	FOXI1	19	4	23	588.336
#27	IRF3	19	4	23	448.4
#28	FOXA2	19	6	25	5877.599
#29	WT1	18	6	24	1301.229
#30	CREBBP	18	8	26	4261.033
#31	PLAGL2	18	2	20	606.307
#32	TAF1B	18	3	21	747.313
#33	RBPJ	18	8	26	7173.914
#34	HMG20B	18	8	26	1052.788
#35	RUNX2	18	6	24	648.083
#36	RARG	18	5	23	1692.481
#37	KLF6	17	4	21	3440.712
#38	CNOT8	17	4	21	4506.006
#39	NFATC4	17	5	22	400.205
#40	SPEN	17	6	23	410.41
#41	FOXA1	17	7	24	2358.824
#42	ESRRB	17	6	23	1213.908
#43	MTA1	17	3	20	567.742
#44	KDM5B	16	3	19	5249.538
#45	HNRNPAB	16	1	17	1323.921
#46	MMP14	16	6	22	854.445
#47	NR4A3	16	4	20	341.11
#48	ZBTB17	16	6	22	1501.895
#49	ZNF207	16	4	20	165.69
#50	BTG2	16	4	20	1115
#51	ZEB1	16	5	21	5181.84
#52	E2F3	16	7	23	1333.363
#53	LASS6	16	6	22	2781.293
#54	GATA4	16	3	19	326.17
#55	YY1	15	5	20	244.391
#56	DRAP1	15	9	24	1901.667
#57	PITX3	15	8	23	2613.246
#58	FOXJ1	15	5	20	378.976
#59	TAF4	15	7	22	11131.774
#60	NR2E3	15	7	22	2613.862
#61	FUBP1	15	8	23	443.322
#62	FEV	15	3	18	93.899
#63	RFX5	14	6	20	1476.148
#64	POU2F2	14	5	19	425.077
#65	LMX1B	14	6	20	648.503
#66	CREB3L2	14	4	18	2728.253
#67	HOXB13	14	4	18	210.914
#68	NR1H2	14	7	21	1011.875
#69	TFDP1	14	6	20	3290.438
#70	MEIS1	14	7	21	2277.077
#71	GTF2H4	14	6	20	1792.955
#72	AFF1	14	6	20	3674.488
#73	HMGB2	14	10	24	2139.338
#74	EMX1	14	2	16	155.79
#75	GTF2H3	14	6	20	13227.027
#76	ASCL2	14	7	21	2955.648
#77	STAT6	13	4	17	526.185
#78	TBP	13	6	19	6430.929
#79	PAX4	13	1	14	244.262
#80	MAX	13	8	21	4258.625
#81	NR2F6	13	4	17	2724.921
#82	BACH1	13	10	23	766.969
#83	FOXJ3	13	7	20	25317.83
#84	TCF3	13	3	16	1206.387
#85	IRF1	13	9	22	3198.172
#86	FOXC2	13	7	20	2470.937
#87	TSC22D4	12	7	19	3030.939
#88	LHX1	12	8	20	6563.281
#89	ZNF131	12	6	18	1549.944
#90	VENTX	12	5	17	340.001
#91	TAF6	12	7	19	1521.26
#92	RB1	12	6	18	7780.668
#93	NFKB2	12	7	19	2040.769
#94	BRD8	12	11	23	4704.333
#95	HIF1A	12	8	20	2498.998
#96	RCOR1	12	3	15	5847.968
#97	HOXA4	11	5	16	1805.786
#98	PAX3	11	7	18	1704.281
#99	EPAS1	11	4	15	206.344
#100	E2F4	11	4	15	465.014
#101	ZFP36L2	11	6	17	946.386
#102	ZNF148	11	10	21	9489.48
#103	CSRNP2	11	7	18	7669.001
#104	DMTF1	11	7	18	11965.6
#105	NR2C1	11	9	20	5555.948
#106	ELK1	11	5	16	994.169
#107	NR5A1	11	5	16	364.143
#108	TFDP2	11	7	18	512.215
#109	TSC22D3	11	7	18	6097.937
#110	NKX2-1	11	5	16	3125.566
#111	SNAI2	11	5	16	382.136
#112	SMAD3	11	8	19	2672.946
#113	RXRB	10	3	13	108.031
#114	TAF10	10	7	17	757.968
#115	MEF2D	10	5	15	2944.846
#116	JUN	10	6	16	580.503
#117	E2F5	10	6	16	200.583
#118	KLF4	10	5	15	1565.63
#119	RARB	10	9	19	1692.08
#120	SRF	10	7	17	4878.181
#121	SIM2	10	4	14	77.659
#122	TCF25	10	5	15	948.204
#123	MLLT10	10	6	16	2694.025
#124	RELA	10	4	14	953.377
#125	TCF12	10	8	18	3891.527
#126	STAT1	10	9	19	3493.022
#127	NFYA	10	7	17	1834.924
#128	JUNB	10	8	18	685.099
#129	RXRA	10	12	22	2337.884
#130	KLF9	9	6	15	952.057
#131	ARID4A	9	11	20	2881.262
#132	CREM	9	8	17	630.138
#133	MAFK	9	7	16	4456.881
#134	CSDA	9	4	13	401.171
#135	ZNF217	9	6	15	4699.961
#136	TEAD4	9	11	20	4234.687
#137	CREBL2	9	7	16	5831.64
#138	IRF9	9	4	13	535.888
#139	RFX1	9	10	19	1389.681
#140	ETV3	9	4	13	102.101
#141	TFAP2B	9	4	13	140.164
#142	RNF4	9	7	16	728.715
#143	SMAD2	9	10	19	2590.268
#144	PITX2	9	5	14	997.092
#145	FOXH1	9	5	14	176.279
#146	DLX2	9	7	16	1449.93
#147	NFX1	9	8	17	3974.636
#148	LMO4	9	7	16	1183.149
#149	MSX1	9	6	15	3833.041
#150	HLF	9	8	17	250.213
#151	ZNF37A	9	3	12	8325.75
#152	HSF4	9	9	18	1322.559
#153	NR1H3	9	6	15	1399.532
#154	TAF12	9	6	15	1630.85
#155	HNF1B	9	6	15	619.978
#156	JUND	8	6	14	516.212
#157	TSC22D2	8	8	16	1919.033
#158	ERG	8	7	15	104.538
#159	SP3	8	9	17	4453.813
#160	NR2F2	8	6	14	191.606
#161	HCFC1	8	11	19	867.676
#162	ARNT	8	12	20	3542.624
#163	MYOG	8	3	11	250.413
#164	AHCTF1	8	9	17	349.547
#165	TCF4	8	8	16	4348.181
#166	E2F1	8	5	13	781.072
#167	TCF15	8	8	16	305.654
#168	HMGA2	8	8	16	597.545
#169	ZNF41	8	8	16	1593.79
#170	STRN3	8	9	17	1638.861
#171	TFAP2A	8	7	15	2207.088
#172	CREBZF	8	4	12	567.835
#173	CITED2	8	13	21	5796.86
#174	BCL3	8	5	13	2278.874
#175	NFYB	8	6	14	632.475
#176	SPIB	8	4	12	368.874
#177	ATF6B	8	7	15	5166.291
#178	HNF4A	8	5	13	54.461
#179	CREB1	8	11	19	592.447
#180	TEAD3	8	6	14	878.625
#181	ZKSCAN1	7	7	14	2259.112
#182	TAF5L	7	8	15	540.968
#183	RBCK1	7	8	15	859.919
#184	ZSCAN12	7	5	12	1366.451
#185	FOXO1	7	7	14	712.354
#186	CTBP1	7	6	13	1572.639
#187	SIX6	7	6	13	852.488
#188	TARDBP	7	6	13	2195.352
#189	SLC30A9	7	8	15	2476.356
#190	ZNF193	7	5	12	1302.266
#191	CNBP	7	5	12	205.068
#192	SIX3	7	4	11	4120.115
#193	TAF5	7	7	14	722.446
#194	CRX	7	6	13	352.523
#195	HNRNPK	7	12	19	3443.418
#196	ZNF263	7	8	15	3078.279
#197	SPDEF	7	10	17	3596.685
#198	HIC1	7	7	14	1569.274
#199	NFATC3	7	7	14	1181.507
#200	FOXN1	7	6	13	657.236
#201	ZNF85	7	8	15	1055.037
#202	ELF2	7	7	14	1704.949
#203	HOXD4	7	5	12	114.985
#204	TAF7	7	6	13	1175.597
#205	TRIM28	7	3	10	922.627
#206	ETV2	7	7	14	907.033
#207	NRL	7	11	18	1869.378
#208	HSF1	7	7	14	848.704
#209	MYOD1	7	7	14	975.636
#210	NKX2-8	7	9	16	774.713
#211	CEBPD	7	3	10	58.311
#212	MYT1	7	6	13	984.246
#213	RARA	7	6	13	1835.34
#214	IRX3	6	9	15	157.124
#215	CDX2	6	7	13	4789.076
#216	BHLHE40	6	7	13	2243.831
#217	HHEX	6	5	11	647.583
#218	ZNF33B	6	7	13	2252.7
#219	PLAG1	6	7	13	2872.845
#220	MYC	6	6	12	1149.864
#221	SOX1	6	6	12	301.521
#222	TRIM25	6	9	15	965.892
#223	CITED1	6	5	11	1983.667
#224	NKX2-5	6	4	10	2298.827
#225	MEOX1	6	11	17	1501.959
#226	PBX1	6	8	14	2804.454
#227	TFCP2	6	9	15	3355.998
#228	GLI2	6	11	17	3534.63
#229	NFKB1	6	8	14	1756.503
#230	SNAPC5	6	8	14	1700.766
#231	PITX1	6	4	10	260.947
#232	EGR2	6	5	11	769.966
#233	HOXD8	6	8	14	4389.638
#234	SMAD5	6	10	16	5134.813
#235	ETV4	6	10	16	1674.534
#236	MEIS2	6	6	12	557.185
#237	ISL1	6	7	13	3218.204
#238	ZNF189	6	9	15	1171.891
#239	ZNF140	6	8	14	430.243
#240	SOX21	6	8	14	1256.059
#241	MGA	6	6	12	906.005
#242	PDX1	6	3	9	704.409
#243	ELK3	6	3	9	3784.945
#244	ZBTB48	6	9	15	989.842
#245	ZNF133	6	7	13	2183.244
#246	MEF2C	6	2	8	42.956
#247	ATF3	6	6	12	2403.602
#248	MYBL2	6	14	20	3220.531
#249	ASCL1	6	8	14	2135.981
#250	PAX7	6	6	12	175.225
#251	FOSL2	5	10	15	560.351
#252	TP53	5	8	13	1879.237
#253	HES1	5	8	13	3420.535
#254	TEAD1	5	10	15	11935.565
#255	TFEC	5	5	10	62.897
#256	FOSL1	5	7	12	1254.661
#257	NFIX	5	12	17	3632.417
#258	POU6F1	5	5	10	1820.979
#259	ADNP2	5	11	16	8191.295
#260	HOXA11	5	8	13	1706.686
#261	STAT3	5	7	12	1231.09
#262	GABPB1	5	7	12	427.04
#263	NFE2L3	5	3	8	1103.706
#264	FOXN3	5	12	17	1221.028
#265	STAT2	5	9	14	1980.085
#266	NOLC1	5	8	13	603.461
#267	FOS	5	18	23	4465.215
#268	VAV1	5	4	9	62.473
#269	AEBP1	5	8	13	3705.198
#270	C11orf9	5	6	11	295.79
#271	TFEB	5	9	14	1953.061
#272	E2F2	5	5	10	1628.041
#273	KLF10	5	9	14	8304.491
#274	HMX1	5	6	11	298.998
#275	ESRRG	5	5	10	774.249
#276	SNAPC2	5	10	15	2499.833
#277	LHX2	5	9	14	2172.225
#278	FOXE1	5	3	8	30.189
#279	MYCN	5	8	13	3439.429
#280	NFIC	5	9	14	2266.027
#281	NFYC	5	7	12	211.559
#282	TWIST1	5	8	13	1116.208
#283	PRDM2	5	5	10	803.771
#284	EGR3	5	12	17	50879.647
#285	ZNF187	5	7	12	12349.816
#286	BCL6	4	5	9	482.139
#287	MSL3	4	8	12	1559.334
#288	TCF7L2	4	7	11	3415.396
#289	NPAT	4	6	10	128.011
#290	NR2F1	4	9	13	920.291
#291	FOXJ2	4	7	11	1752.647
#292	EN2	4	7	11	2457.31
#293	RELB	4	8	12	543.958
#294	IKZF1	4	6	10	41.933
#295	BUD31	4	5	9	18767.506
#296	NFIB	4	11	15	3691.471
#297	ELF1	4	8	12	76.482
#298	CEBPA	4	8	12	371.489
#299	MLL	4	5	9	6468.626
#300	NR4A1	4	8	12	3837.077
#301	PCGF2	4	8	12	223.551
#302	HOXB3	4	11	15	416.776
#303	ALX1	4	8	12	106.63
#304	ZFP37	4	4	8	1241.195
#305	HOXC11	4	7	11	1988.566
#306	SOLH	4	8	12	1029.743
#307	THRA	4	7	11	478.744
#308	HOXD10	4	8	12	2671.069
#309	SREBF2	4	6	10	552.826
#310	ELK4	4	4	8	368.541
#311	TADA3	4	6	10	46.84
#312	BATF	4	8	12	441.254
#313	SOX13	4	5	9	1239.116
#314	UBN1	4	7	11	796.955
#315	IRF2	4	7	11	1595.55
#316	MAFF	4	10	14	1559.185
#317	HOXD9	4	12	16	1184.134
#318	PHTF1	4	10	14	716.675
#319	ZNF197	3	3	6	789.106
#320	ONECUT2	3	6	9	461.328
#321	IRX5	3	9	12	176.756
#322	PA2G4	3	10	13	813.683
#323	NR1D2	3	14	17	5932.513
#324	CBL	3	9	12	14170.937
#325	BLZF1	3	11	14	1168.822
#326	POU1F1	3	10	13	3089.91
#327	CREB3	3	5	8	147.382
#328	ZNF24	3	9	12	578.741
#329	POU2F1	3	9	12	3025.851
#330	TBX2	3	7	10	590.333
#331	MBD1	3	6	9	862.305
#332	ZIC2	3	8	11	477.163
#333	IRF4	3	5	8	4958.954
#334	ZNF35	3	4	7	461.423
#335	VTN	3	12	15	296.601
#336	SUPT6H	3	11	14	1352.943
#337	ETS1	3	5	8	70.994
#338	TBX1	3	6	9	868.19
#339	TBX5	3	8	11	3136.744
#340	MTF1	3	8	11	1046.752
#341	HNF1A	3	6	9	546.992
#342	HMGA1	3	8	11	1165.185
#343	TRIM22	3	10	13	1294.344
#344	TGIF1	3	10	13	1510.182
#345	HOXD13	3	2	5	58.483
#346	MECOM	3	9	12	774.458
#347	PPARD	3	7	10	340.973
#348	GATAD1	3	9	12	549.822
#349	PTTG1	3	12	15	528.247
#350	ZHX3	3	7	10	656.628
#351	KLF5	3	9	12	1278.091
#352	ERF	3	8	11	474.425
#353	TCF21	3	8	11	467.811
#354	GBX1	3	5	8	2694.064
#355	SMAD1	3	11	14	1021.991
#356	FOXM1	3	13	16	1589.686
#357	TCF20	3	9	12	668.72
#358	GATA1	3	6	9	1786.128
#359	HOXB2	3	8	11	1403.95
#360	SATB1	3	9	12	4787.112
#361	GATA2	3	13	16	20403.013
#362	FOXC1	3	9	12	330.951
#363	FOXO3	3	8	11	1204.802
#364	NFE2L2	3	11	14	584.948
#365	ZNF117	3	9	12	1024.317
#366	NPAS1	3	8	11	2784.477
#367	ZIC1	3	8	11	279.919
#368	FOXD2	3	6	9	172.368
#369	IRF8	3	5	8	15.665
#370	SREBF1	2	9	11	265.736
#371	CTNNB1	2	8	10	1552.034
#372	HIRA	2	13	15	1843.716
#373	ETV1	2	12	14	1028.683
#374	VDR	2	10	12	562.171
#375	ZFHX3	2	12	14	620.258
#376	EGR1	2	11	13	134.769
#377	XBP1	2	5	7	30.311
#378	E2F6	2	9	11	303.669
#379	TFAP4	2	11	13	441.893
#380	CDKN2A	2	7	9	2048.642
#381	FOXK2	2	6	8	57.677
#382	ATF1	2	5	7	1712.442
#383	TAF4B	2	9	11	5912.055
#384	SOX4	2	12	14	1686.987
#385	SUPT4H1	2	8	10	228.366
#386	TAF13	2	8	10	603.819
#387	FOXF1	2	5	7	556.61
#388	PBX3	2	9	11	1758.62
#389	PHF1	2	12	14	859.135
#390	ENO1	2	7	9	1092.852
#391	SMAD9	2	4	6	124.927
#392	HOXD3	2	2	4	83.336
#393	ZNF75D	2	7	9	390.954
#394	ZNF45	2	10	12	3708.273
#395	SP1	2	5	7	64.949
#396	MZF1	2	7	9	534.91
#397	TEF	2	5	7	94.177
#398	CREB3L1	2	12	14	1284.36
#399	GAS7	2	8	10	1254.349
#400	NFE2L1	2	8	10	107.904
#401	KLF12	2	10	12	659.739
#402	PRRX1	2	7	9	1775.028
#403	ESR1	2	7	9	396.887
#404	GCM1	2	4	6	545.851
#405	SOX10	2	10	12	43.482
#406	SRY	2	8	10	4145.149
#407	ZNF134	2	6	8	1396.741
#408	PAX6	2	6	8	1549.835
#409	MITF	2	6	8	202.711
#410	MEIS3P1	2	4	6	187.275
#411	ARNT2	1	10	11	1131.522
#412	SMAD6	1	7	8	4553.908
#413	GTF2H2	1	5	6	1191.664
#414	NFATC1	1	8	9	128.352
#415	POU4F1	1	9	10	64.266
#416	TCEAL1	1	5	6	1414.368
#417	ZNF165	1	9	10	69.128
#418	NR4A2	1	4	5	81.075
#419	ZNF91	1	8	9	1517.24
#420	GABPA	1	6	7	1013.948
#421	CUX1	1	8	9	24.105
#422	STAT4	1	8	9	2629.272
#423	ETV5	1	5	6	79.065
#424	FOXN2	1	6	7	64.707
#425	IRF7	1	6	7	120.969
#426	ATF5	1	8	9	74.177
#427	MYCL2	1	8	9	516.963
#428	NFIL3	1	10	11	3422.978
#429	DLX4	1	3	4	46.912
#430	DDIT3	1	11	12	74.816
#431	POU6F2	1	8	9	560.411
#432	NFAT5	1	11	12	637.536
#433	C2orf3	1	10	11	42.851
#434	POU3F4	1	8	9	573.741
#435	GATA3	1	7	8	61.451
#436	AATF	1	10	11	262.691
#437	KDM5A	1	7	8	87.95
#438	ETS2	1	9	10	3933.415
#439	RFXANK	1	7	8	87.602
#440	TFE3	1	8	9	68.744
#441	FOXO4	1	8	9	84.798
#442	LZTR1	1	9	10	46.286
#443	SOX30	1	8	9	75.925
#444	MNT	1	11	12	127.547
#445	HOXB5	1	10	11	83.01
#446	ZNF175	1	4	5	22.512
#447	PRDM1	1	6	7	56.853
#448	SALL2	1	6	7	34.218
#449	TADA2A	1	10	11	1024.501
#450	TGIF2	1	9	10	92.176
#451	TCF7	1	5	6	858.646
#452	SPI1	1	9	10	1304.095
#453	SP4	1	2	3	287.632
#454	CEBPE	1	4	5	8.617
#455	ZNF154	1	7	8	95.61
#456	CBFA2T3	1	7	8	301.398
#457	REST	1	2	3	66.606
#458	GBX2	1	9	10	77.82
#459	TRIM29	1	12	13	175.923
#460	CBFB	1	6	7	29.373
#461	SOX15	1	6	7	479.43
#462	ZNF500	1	6	7	43.35
#463	RCAN1	1	11	12	725.091
#464	ESRRA	0	8	8	0
#465	ARNTL	0	7	7	0
#466	SOX5	0	5	5	0
#467	ESR2	0	9	9	0
#468	REL	0	7	7	0
#469	CEBPB	0	6	6	0
#470	USF2	0	8	8	0
#471	RUNX3	0	7	7	0
#472	MXD1	0	11	11	0
#473	ETV6	0	4	4	0
#474	ZNF268	0	7	7	0
#475	ZNF132	0	8	8	0
#476	HSF2	0	9	9	0
#477	PBX2	0	9	9	0
#478	CIR1	0	10	10	0
#479	ELF4	0	8	8	0
#480	ZNF274	0	7	7	0
#481	HOXB6	0	10	10	0
#482	ATF4	0	12	12	0
#483	SIX1	0	12	12	0
#484	PPARG	0	8	8	0
#485	STAT5B	0	9	9	0
#486	NR3C1	0	4	4	0
#487	ONECUT1	0	6	6	0
#488	IRF5	0	4	4	0
#489	TBR1	0	4	4	0
#490	ZNF643	0	7	7	0
#491	HOXA10	0	5	5	0
#492	HOXC4	0	5	5	0
#493	MAF	0	5	5	0
#494	SOX11	0	3	3	0
#495	MLX	0	8	8	0
#496	RFXAP	0	9	9	0
#497	ZNF167	0	6	6	0
#498	FOSB	0	9	9	0
#499	ARID3A	0	12	12	0
#500	CLOCK	0	8	8	0