Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	ETS2	119	1	120	3.708
#2	CSRNP1	106	16	122	918.096
#3	SOX7	105	1	106	1035.299
#4	ZNF396	105	4	109	10442.922
#5	FOXA1	102	1	103	274.292
#6	MAFF	98	10	108	699.944
#7	MAFK	98	20	118	495.546
#8	HOXA2	96	11	107	139.642
#9	E2F7	96	4	100	45.163
#10	NFKB1	91	18	109	560.633
#11	NFE2L2	90	27	117	450.177
#12	FOSL1	83	2	85	1.617
#13	TGIF2LY	82	14	96	62.658
#14	FOSL2	80	23	103	541.905
#15	POU3F1	79	11	90	81.824
#16	RORB	78	13	91	115.855
#17	ESRRB	77	7	84	64.325
#18	SMAD6	76	7	83	21.284
#19	SPEN	76	24	100	229.382
#20	ATF3	75	19	94	98.762
#21	RAX2	74	25	99	1185.196
#22	ZNF117	72	5	77	553.756
#23	ZNF500	72	10	82	1310.773
#24	FOXM1	72	7	79	1552.988
#25	ARNT	71	19	90	560.479
#26	SPDEF	70	4	74	711.344
#27	ZNF215	70	8	78	73.331
#28	SOX17	69	16	85	618.784
#29	NFATC2	68	22	90	350.309
#30	MLLT10	68	12	80	66.806
#31	BCL6	66	26	92	176.312
#32	TSC22D2	66	18	84	49.966
#33	FOXC1	65	9	74	1070.949
#34	IRX4	64	26	90	306.908
#35	MAFG	64	32	96	3474.36
#36	GLI2	62	33	95	1150.357
#37	POU2F1	61	12	73	21.75
#38	NFIL3	61	32	93	254.985
#39	ZBTB38	61	22	83	2361.279
#40	ERG	61	14	75	56.125
#41	ERF	60	24	84	179.073
#42	PAX8	60	23	83	611.422
#43	BLZF1	60	22	82	605.935
#44	HOXC9	59	3	62	19.344
#45	FOXO1	58	22	80	358.884
#46	HOXB7	58	20	78	172.134
#47	SLC2A4RG	57	12	69	783.367
#48	NFE2L3	56	10	66	873.195
#49	CEBPD	55	33	88	997.174
#50	HOXB2	54	24	78	26631.217
#51	GATA3	54	10	64	308.068
#52	XBP1	54	12	66	318.451
#53	REL	54	37	91	876.041
#54	TAF4B	54	33	87	2976.268
#55	SOX12	53	25	78	3766.312
#56	ESR1	53	14	67	740.491
#57	KLF10	53	27	80	396.39
#58	SOX6	52	10	62	2205.799
#59	ZFP36L2	52	30	82	346.278
#60	MEF2D	52	32	84	917.292
#61	EN1	52	14	66	634.006
#62	ZFHX3	52	13	65	364.227
#63	NKX3-1	51	25	76	7779.537
#64	E2F3	51	11	62	372.432
#65	ZNF207	50	25	75	383.264
#66	CBFA2T2	50	20	70	1533.163
#67	LASS5	50	16	66	421.302
#68	NFAT5	49	30	79	581.73
#69	CSDA	49	28	77	1500.548
#70	JUND	48	23	71	911.182
#71	SOX11	48	27	75	3365.7
#72	NFKB2	48	32	80	353.504
#73	KLF9	48	28	76	1556.303
#74	FOSB	48	12	60	220.675
#75	TP63	48	13	61	1088.947
#76	ZIC1	47	12	59	931.88
#77	BACH2	47	35	82	773.438
#78	ZNF397	47	14	61	476.031
#79	NFIA	46	15	61	997.137
#80	TCF19	46	12	58	661.269
#81	PBX1	46	14	60	223.519
#82	IRF1	46	29	75	571.451
#83	MTA3	46	34	80	1402.189
#84	UHRF1	46	26	72	1196.747
#85	CDKN2A	45	10	55	572.79
#86	C1orf85	45	24	69	4763.111
#87	ZNF445	44	6	50	1110.14
#88	NRL	44	9	53	686.627
#89	ETV6	44	22	66	1095.663
#90	SOX10	44	13	57	2762.296
#91	LASS6	43	11	54	537.885
#92	NFATC1	43	33	76	612.266
#93	ZNF33A	43	26	69	1801.646
#94	E2F1	42	15	57	438.083
#95	SOX13	42	22	64	1240.491
#96	KLF4	42	29	71	2586.858
#97	CREB3L4	42	16	58	658.25
#98	KLF6	42	32	74	768.662
#99	CREB1	42	21	63	819.149
#100	PURA	41	19	60	1062.066
#101	SPIB	41	7	48	248.8
#102	SMAD2	41	20	61	560.415
#103	TSC22D1	41	37	78	711.939
#104	STAT2	41	24	65	903.345
#105	RFX1	41	32	73	775.166
#106	SNAPC5	41	25	66	609.31
#107	MLX	41	14	55	1191.365
#108	MZF1	40	29	69	301.38
#109	HNF4A	40	7	47	188.874
#110	EPAS1	40	29	69	880.735
#111	AR	40	12	52	648.899
#112	MSRB2	40	36	76	3517.69
#113	MYCN	40	16	56	1147.955
#114	TCFL5	39	35	74	1239.744
#115	IKZF1	39	4	43	586.175
#116	ETS1	39	25	64	406.324
#117	SMAD4	39	23	62	638.346
#118	ELK3	39	20	59	237.836
#119	YBX1	39	27	66	2097.033
#120	SOX8	38	8	46	141.778
#121	EGR3	38	12	50	53.401
#122	NR6A1	38	9	47	122.903
#123	ESRRA	38	21	59	699.093
#124	ZNF135	38	25	63	1466.44
#125	NR4A2	38	27	65	399.567
#126	GLI3	38	24	62	1311.502
#127	SOX2	38	17	55	1180.555
#128	ZNF92	37	18	55	412.728
#129	USF2	37	17	54	1148.518
#130	JUNB	37	28	65	511.491
#131	GATA4	37	2	39	161.729
#132	PRDM1	37	25	62	882.903
#133	EBF1	37	14	51	197.985
#134	EGR1	37	15	52	115.245
#135	PTTG1	36	17	53	700.799
#136	POU5F1B	36	17	53	356.448
#137	CREB3L1	36	19	55	1095.189
#138	GTF2H4	36	8	44	301.343
#139	HIC1	36	23	59	576.5
#140	TCF3	36	21	57	1400.788
#141	ZSCAN18	36	19	55	2269.354
#142	PHF5A	36	32	68	1994.956
#143	HOXC10	36	16	52	937.003
#144	ZNF323	36	20	56	1838.641
#145	TFDP3	36	6	42	198.729
#146	LMO4	35	24	59	579.477
#147	ZNF277	35	26	61	909.175
#148	HDAC2	35	28	63	1129.276
#149	GABPA	35	26	61	872.983
#150	BRD8	35	22	57	366.956
#151	MSX1	35	31	66	88.637
#152	TFAP2A	35	34	69	587.453
#153	NR4A1	34	13	47	129.441
#154	SCAND1	34	31	65	2456.506
#155	CREB3L3	34	20	54	963.924
#156	EGR2	34	16	50	87.974
#157	SCML1	34	33	67	266.732
#158	HOXC4	34	7	41	88.47
#159	RERE	34	21	55	1021.988
#160	HOXD10	34	26	60	1151.43
#161	CEBPB	34	35	69	1533.205
#162	RXRA	33	27	60	755.052
#163	MYC	33	40	73	635.625
#164	NR2F1	33	18	51	1351.988
#165	TFAP2B	33	19	52	908.29
#166	NOLC1	33	30	63	478.059
#167	MAX	32	41	73	700.007
#168	ZEB2	32	35	67	655.937
#169	TSHZ2	32	22	54	527.531
#170	KLF5	32	42	74	985.288
#171	ZNF213	32	12	44	350.915
#172	SLC30A9	32	31	63	726.494
#173	HMGB2	32	24	56	1036.318
#174	NFYA	32	9	41	395.334
#175	RELB	32	23	55	1955.867
#176	IRF8	32	10	42	437.477
#177	SCMH1	32	23	55	763.07
#178	MBD1	31	34	65	3042.274
#179	ELF1	31	41	72	935.685
#180	KLF3	31	33	64	704.313
#181	E2F4	31	16	47	1082.018
#182	RUNX1T1	31	18	49	258.845
#183	ZNF24	31	25	56	868.953
#184	FOXN2	31	42	73	1608.316
#185	BCL3	31	38	69	818.34
#186	SUPT6H	31	32	63	1340.981
#187	ZNF449	30	27	57	971.008
#188	TBX3	30	22	52	663.378
#189	EOMES	30	8	38	219.983
#190	RUNX2	30	23	53	806.94
#191	CREBBP	30	28	58	359.053
#192	ZRANB2	30	28	58	411.029
#193	HSF2	30	28	58	781.311
#194	DMTF1	30	28	58	734.946
#195	ATF4	30	26	56	472.985
#196	ADNP2	29	33	62	1047.772
#197	CSRNP2	29	45	74	625.013
#198	CREBZF	29	18	47	748.241
#199	SMAD3	29	32	61	393.004
#200	ZNF444	29	36	65	1159.478
#201	SOX1	29	5	34	63.773
#202	HOXA5	29	26	55	473.493
#203	MAF	29	27	56	791.977
#204	STAT1	29	24	53	924.134
#205	MLL	28	34	62	514.696
#206	CTCF	28	30	58	719.3
#207	ELF2	28	14	42	155.562
#208	ZNF367	28	21	49	454.215
#209	ARX	28	18	46	1406.209
#210	RFX5	28	24	52	626.255
#211	HOXA9	28	14	42	1364.089
#212	POU4F1	28	13	41	377.479
#213	ZNF236	28	12	40	84.403
#214	CTNNB1	28	31	59	1481.661
#215	TWIST2	28	29	57	324.311
#216	ELF5	28	25	53	774.597
#217	NFATC4	28	24	52	840.464
#218	SIX3	28	20	48	1953.903
#219	ZNF138	28	21	49	342.572
#220	KLF11	28	39	67	2717.645
#221	ARNTL2	27	18	45	757.857
#222	NR4A3	27	31	58	463.133
#223	ZSCAN29	27	25	52	823.375
#224	FOXN4	27	28	55	1025.013
#225	ZFP90	27	35	62	735.231
#226	HMGA1	27	34	61	510.54
#227	SIX1	27	22	49	2219.951
#228	TADA3	27	43	70	1082.38
#229	TSHZ1	27	40	67	1224.046
#230	RCAN1	27	38	65	733.135
#231	CREM	27	37	64	537.782
#232	MEF2C	27	29	56	1127.032
#233	RUNX1	27	4	31	21.586
#234	PAX3	27	18	45	988.619
#235	AFF4	26	36	62	482.69
#236	HMGB1	26	42	68	891.939
#237	RELA	26	40	66	599.533
#238	L3MBTL4	26	20	46	865.286
#239	PITX1	26	30	56	1453.845
#240	AFF1	26	22	48	646.713
#241	ASCL1	26	11	37	184.265
#242	TEAD1	26	31	57	180.957
#243	GATAD2A	26	29	55	233.792
#244	TCF7	26	20	46	537.602
#245	SOX21	26	7	33	135.758
#246	SP1	26	30	56	429.962
#247	BTAF1	26	30	56	473.715
#248	GABPB1	25	23	48	210.556
#249	HR	25	24	49	1181.731
#250	KDM5B	25	36	61	836.349
#251	KDM5A	25	30	55	553.497
#252	MYBL2	25	31	56	1737.042
#253	YEATS4	25	37	62	1212.925
#254	AHCTF1	25	21	46	343.695
#255	BACH1	25	36	61	1061.162
#256	BTG2	25	20	45	310.467
#257	MEOX1	25	32	57	387.288
#258	ETV5	25	28	53	1113.536
#259	RFXANK	25	29	54	1119.364
#260	IRF2	24	45	69	910.383
#261	RXRB	24	26	50	511.779
#262	JUN	24	17	41	72.932
#263	SRF	24	33	57	868.23
#264	TSC22D4	24	35	59	827.583
#265	NFIC	24	24	48	798.016
#266	NR1I3	24	21	45	282.063
#267	KLF7	24	41	65	690.695
#268	HOPX	24	33	57	1534.7
#269	ZNF639	24	30	54	496.363
#270	STRN3	24	28	52	784.778
#271	ANKRD30A	24	24	48	1366.644
#272	HMG20B	23	42	65	1028.358
#273	FOXP1	23	34	57	1787.673
#274	STAT3	23	46	69	818.782
#275	ZNF165	23	35	58	226.489
#276	MXD1	23	39	62	588.748
#277	GATA6	23	22	45	795.931
#278	GAS7	23	25	48	1143.046
#279	ZNF232	23	39	62	1901.367
#280	HCLS1	23	22	45	476.474
#281	ZKSCAN1	23	36	59	324.041
#282	ETV3	23	35	58	922.462
#283	IRX1	23	41	64	753.173
#284	FUBP1	23	43	66	1468.202
#285	TEAD4	23	34	57	714.56
#286	UBN1	23	41	64	944.159
#287	PAX4	22	21	43	895.032
#288	NR3C1	22	29	51	296.356
#289	HEY1	22	37	59	1302.054
#290	TCF20	22	32	54	702.186
#291	ATF5	22	30	52	423.893
#292	KLF16	22	41	63	403.81
#293	TEAD2	22	33	55	805.799
#294	PGR	22	21	43	1582.555
#295	IRF6	22	36	58	514.832
#296	TEF	21	33	54	474.027
#297	CITED1	21	27	48	1256.031
#298	SATB1	21	36	57	777.085
#299	ZEB1	21	22	43	731.337
#300	NCOR1	21	34	55	952.413
#301	MTA1	21	26	47	896.706
#302	CBL	21	38	59	387.802
#303	TGIF1	21	38	59	191.627
#304	PLSCR1	21	36	57	725.345
#305	LCOR	21	36	57	450.128
#306	FOXK2	21	32	53	820.403
#307	ZXDC	21	40	61	719.164
#308	NR2F6	21	29	50	1250.634
#309	CNOT7	21	36	57	1316.08
#310	ELK1	21	21	42	143.337
#311	ZNF93	21	18	39	322.582
#312	TRPS1	21	46	67	674.348
#313	TCF12	20	20	40	831.652
#314	FOXJ2	20	32	52	299.102
#315	IRX5	20	26	46	446.648
#316	BUD31	20	34	54	1216.852
#317	ETV4	20	35	55	705.571
#318	GCFC1	20	32	52	1078.081
#319	CITED2	20	42	62	1605.215
#320	FOXJ1	20	22	42	827.551
#321	FOXP4	20	32	52	1279.881
#322	FOXC2	20	33	53	2471.311
#323	REST	19	33	52	1152.447
#324	BHLHE40	19	33	52	499.492
#325	IRX2	19	49	68	2722.459
#326	IRF9	19	27	46	627.302
#327	TFDP1	19	26	45	872.987
#328	HOXB3	19	35	54	1158.472
#329	TP53	19	38	57	1297.379
#330	SMAD5	19	38	57	1248.261
#331	FOXN3	19	24	43	382.417
#332	PHF1	19	39	58	1644.775
#333	CNOT8	19	29	48	854.086
#334	RB1	19	33	52	789.942
#335	MESP1	19	33	52	738.243
#336	CLOCK	19	52	71	910.769
#337	TFE3	19	33	52	1126.674
#338	NFIB	18	24	42	457.685
#339	ZNF85	18	21	39	467.521
#340	GTF2IRD1	18	34	52	807.872
#341	HNRNPK	18	49	67	1515.936
#342	PCGF2	18	20	38	614.74
#343	C5orf41	18	40	58	941.147
#344	FOS	18	12	30	113.157
#345	TAL1	18	36	54	1211.189
#346	GATA2	18	32	50	935.849
#347	LEF1	17	36	53	1077.372
#348	TWIST1	17	42	59	487.753
#349	SCML2	17	43	60	519.624
#350	KLF2	17	29	46	283.092
#351	GRHL2	17	47	64	2126.781
#352	MEIS3P1	17	35	52	373.344
#353	NOTCH1	17	40	57	2291.255
#354	VDR	17	42	59	198.223
#355	LASS2	17	36	53	695.004
#356	HIRA	16	38	54	931.568
#357	ATF2	16	40	56	1700.339
#358	ELF3	16	30	46	186.687
#359	GTF2I	16	33	49	799.4
#360	TFAM	16	45	61	1700.154
#361	SREBF1	16	23	39	236.63
#362	FBXW7	16	33	49	567.87
#363	HMG20A	16	41	57	314.047
#364	SP3	16	50	66	784.207
#365	UBP1	16	35	51	390.324
#366	CREB3	16	36	52	1653.591
#367	HAND2	16	17	33	319.681
#368	MEIS2	16	37	53	353.058
#369	STAT6	16	33	49	853.245
#370	HIF1A	16	37	53	809.47
#371	SOX9	16	37	53	566.586
#372	HSF1	15	39	54	762.082
#373	TAF6	15	28	43	594.262
#374	ENO1	15	49	64	1007.208
#375	ZFP36L1	15	39	54	756.744
#376	HCFC1	15	39	54	1631.672
#377	DLX1	15	29	44	683.153
#378	MMP14	15	22	37	176.023
#379	BHLHE41	15	34	49	526.962
#380	NFYC	15	36	51	1114.9
#381	ZNF263	15	38	53	1031.751
#382	HDAC1	14	44	58	738.502
#383	TRIM22	14	37	51	559.717
#384	SIX4	14	38	52	260.461
#385	CREB3L2	14	49	63	985.404
#386	PBX3	14	33	47	1078.269
#387	TSHZ3	14	40	54	1048.708
#388	ZNF83	14	40	54	451.025
#389	ZNF148	14	45	59	909.402
#390	FOXO3	14	36	50	487.963
#391	MSX2	14	39	53	723.319
#392	RBPJ	14	50	64	1263.559
#393	MTF1	14	41	55	672.796
#394	GTF2H3	14	29	43	530.015
#395	SLC26A3	14	27	41	402.349
#396	HEY2	13	45	58	637.933
#397	GLIS2	13	43	56	362.445
#398	YY1	13	33	46	335.136
#399	TARDBP	13	59	72	1536.411
#400	FOXP2	13	37	50	1478.156
#401	TCF7L1	13	46	59	400.415
#402	ZHX1	13	44	57	791.994
#403	ZNF217	13	37	50	818.58
#404	E2F5	13	25	38	728.153
#405	CNBP	13	49	62	779.025
#406	WNT5A	13	46	59	1709.928
#407	PBX2	13	41	54	4952.654
#408	HOXB6	13	39	52	1129.371
#409	TCF4	13	23	36	284.218
#410	FOXK1	13	45	58	1585.784
#411	TCEAL1	13	32	45	922.794
#412	STAT5B	13	13	26	190.526
#413	PPARA	13	23	36	498.894
#414	RARA	13	28	41	266.334
#415	NFIX	13	40	53	679.159
#416	TCF7L2	12	30	42	398.29
#417	SIN3A	12	38	50	337.175
#418	TRIM29	12	37	49	472.927
#419	SUPT4H1	12	42	54	737.153
#420	ZFPM1	12	34	46	202.609
#421	IRF3	12	37	49	228.169
#422	SIX2	12	38	50	502.436
#423	SNAI2	12	41	53	604.065
#424	IRF7	12	37	49	884.273
#425	CREBL2	11	38	49	613.913
#426	ZNF238	11	45	56	2037.102
#427	TFAP2C	11	39	50	777.748
#428	AATF	11	26	37	441.238
#429	TGIF2	11	49	60	734.95
#430	ATF6	11	37	48	479.157
#431	RNF4	11	41	52	650.501
#432	GTF2H2	11	36	47	396.735
#433	GATAD2B	11	44	55	484.091
#434	PRDM2	10	41	51	314.836
#435	MYNN	10	31	41	647.328
#436	KLF12	10	13	23	295.305
#437	GATAD1	10	41	51	1236.135
#438	PRRX1	10	29	39	512.878
#439	TBX1	10	48	58	508.387
#440	AHR	10	47	57	310.353
#441	THRB	10	32	42	275.028
#442	PEG3	10	42	52	625.3
#443	CUX1	10	40	50	1943.613
#444	ZNF91	9	41	50	1113.854
#445	STAT5A	9	43	52	236.503
#446	THRA	9	37	46	475.31
#447	IRX3	9	38	47	579.291
#448	EGR4	9	34	43	305.764
#449	HNRNPAB	9	54	63	1531.367
#450	RORA	8	36	44	355.443
#451	RUNX3	8	47	55	617.199
#452	NR1D2	8	41	49	678.68
#453	AEBP1	8	39	47	541.75
#454	RORC	8	48	56	705.952
#455	PA2G4	8	43	51	532.032
#456	SREBF2	7	49	56	524.837
#457	MEF2A	7	35	42	106.031
#458	TRIM28	7	51	58	242.882
#459	NFE2L1	7	48	55	1642.365
#460	ZNF268	7	42	49	270.471
#461	HES1	7	43	50	203.167
#462	ADNP	7	40	47	362.192
#463	TRIM25	7	38	45	1116.026
#464	PURB	7	42	49	214.561
#465	SOLH	7	41	48	300.893
#466	TFCP2L1	7	40	47	341.446
#467	PFDN1	7	35	42	183.592
#468	TAF10	7	38	45	344.825
#469	NR1H3	6	52	58	7541.219
#470	CTBP1	6	43	49	234.544
#471	TULP4	6	49	55	266.367
#472	NR2F2	6	42	48	306.862
#473	ZNF281	6	53	59	260.563
#474	MGA	6	26	32	105.887
#475	BATF	6	51	57	383.44
#476	CEBPA	6	36	42	231.923
#477	CBFB	5	51	56	213.09
#478	DDIT3	5	39	44	177.962
#479	JDP2	5	40	45	749.021
#480	FOXJ3	5	48	53	6256.646
#481	ZHX2	5	48	53	218.979
#482	HMBOX1	5	37	42	227.766
#483	TFDP2	5	40	45	417.117
#484	RBCK1	5	46	51	96.518
#485	EDF1	5	38	43	120.031
#486	TCF25	4	52	56	321.793
#487	SMAD1	4	53	57	413.661
#488	ZNF131	4	51	55	826.664
#489	EHF	4	41	45	103.491
#490	ARNT2	4	50	54	474.698
#491	SOX4	4	44	48	123.899
#492	MAFB	4	49	53	135.066
#493	DRAP1	3	39	42	297.665
#494	TSC22D3	3	51	54	366.26
#495	ARNTL	3	55	58	435.5
#496	SIX5	2	50	52	156.156
#497	TAF7	2	50	52	236.416
#498	NR2C2	2	54	56	226.42
#499	OVOL1	2	48	50	142.996
#500	FOXO6	2	39	41	338.085