Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	TRIM25	54	3	57	269.714
#2	ZSCAN18	52	3	55	79.582
#3	NFYC	51	5	56	2416.195
#4	BTG2	48	4	52	437.371
#5	ESR2	43	5	48	457.901
#6	NR2C1	42	7	49	1260.828
#7	RUNX1T1	40	4	44	300.618
#8	ZKSCAN1	40	5	45	205.894
#9	RUNX1	38	3	41	669.303
#10	NR2E3	37	1	38	426.878
#11	JUN	37	7	44	670.666
#12	CREB3L3	36	7	43	955.552
#13	PRRX1	35	6	41	800.88
#14	SNAPC5	35	12	47	5170.179
#15	IRX1	34	8	42	1071.753
#16	MEIS1	33	7	40	1908.293
#17	ELF5	33	6	39	528.021
#18	SALL2	33	4	37	344.03
#19	PAX8	32	8	40	557.606
#20	RARA	32	6	38	519.332
#21	ATF6B	32	8	40	1942.352
#22	TSC22D1	31	5	36	553.745
#23	RBPJL	30	8	38	183.737
#24	HNRNPK	30	10	40	2021.549
#25	TBX5	30	11	41	1056.006
#26	FOXK2	29	14	43	1613.27
#27	EGR2	29	5	34	1058.461
#28	HOXA4	29	12	41	3479.072
#29	CREB3L1	29	11	40	1426.48
#30	TFAP2A	28	6	34	734.681
#31	HDAC1	28	8	36	1701.943
#32	STRN3	28	11	39	582.538
#33	IRF4	28	9	37	793.828
#34	HCFC1	28	11	39	4289.525
#35	MLLT10	28	6	34	721.091
#36	POU2F2	27	3	30	877.625
#37	PBX3	27	11	38	1359.221
#38	TBP	27	9	36	956.444
#39	DMRT2	27	13	40	1632.228
#40	NFIB	27	16	43	2033.067
#41	ZNF445	27	8	35	701.63
#42	CNOT7	26	12	38	1206.08
#43	NOTCH1	26	13	39	2870.723
#44	XBP1	26	6	32	1023.262
#45	STAT1	26	6	32	1492.956
#46	RXRA	26	12	38	2988.348
#47	FOXA3	25	6	31	623.152
#48	FOSL1	25	12	37	2811.127
#49	CREBZF	25	9	34	437.257
#50	TEF	25	8	33	854.763
#51	LHX4	25	9	34	703.01
#52	ZSCAN29	24	13	37	1357.593
#53	CREB1	24	8	32	504.186
#54	HOXB3	24	9	33	978.266
#55	SOX4	23	8	31	566.343
#56	TP63	23	9	32	703.748
#57	RBPJ	23	4	27	424.975
#58	HIF1A	23	15	38	3011.555
#59	HSF2	22	14	36	1137.294
#60	HOXB7	22	8	30	1161.328
#61	CITED2	22	7	29	563.619
#62	ZFPM2	22	12	34	1158.683
#63	MLL	22	11	33	733.402
#64	SMAD5	22	3	25	490.049
#65	MNX1	21	8	29	544.567
#66	DLX1	21	6	27	356.213
#67	PRDM1	21	15	36	1917.081
#68	NFIX	21	6	27	444.744
#69	SRF	20	12	32	789.611
#70	TFEC	20	10	30	923.214
#71	EN1	20	13	33	734.522
#72	GSC	20	13	33	1483.289
#73	POU5F2	20	10	30	1228.596
#74	ZNF81	20	9	29	407.011
#75	ZNF174	20	9	29	1177.006
#76	CSRNP3	20	8	28	771.193
#77	TCF7L1	19	12	31	2914.505
#78	ZFP36L1	19	12	31	2149.485
#79	SOX17	19	12	31	1708.038
#80	WNT5A	19	8	27	795.444
#81	RHOXF2	19	10	29	396.058
#82	SMAD4	19	9	28	1297.337
#83	SPDEF	19	13	32	1369.62
#84	ZKSCAN2	19	9	28	1315.265
#85	ARNT	19	7	26	267.464
#86	IRX4	19	16	35	2363.171
#87	TSC22D3	19	10	29	1667.084
#88	MNT	18	12	30	2773.351
#89	NR1D1	18	12	30	593.822
#90	REL	18	10	28	753.669
#91	ESRRB	18	14	32	1420.679
#92	ETS2	18	14	32	1919.256
#93	CSDA	18	10	28	774.397
#94	ZFPM1	18	9	27	563.979
#95	CEBPA	18	11	29	331.04
#96	RAX	18	12	30	985.148
#97	TGIF2LY	18	12	30	1473.415
#98	ZNF397	18	15	33	1196.474
#99	HMGA1	18	9	27	1396.501
#100	GABPB1	18	12	30	1065.905
#101	GATA2	18	8	26	1527.202
#102	GLIS3	18	9	27	1791.534
#103	STAT2	18	11	29	536.473
#104	SOX11	18	11	29	1769.539
#105	HNF1B	18	12	30	2010.157
#106	IKZF1	18	12	30	2344.658
#107	MXD1	17	12	29	2040.129
#108	SMAD9	17	14	31	2537.634
#109	NKX2-1	17	14	31	1303.105
#110	SNAPC4	17	16	33	986.731
#111	DDIT3	17	14	31	2017.342
#112	NFIL3	17	6	23	1582.924
#113	HOXA10	17	13	30	1745.382
#114	JUNB	17	12	29	1138.182
#115	ARNTL2	17	11	28	912.854
#116	CEBPB	17	13	30	978.628
#117	GTF2I	17	2	19	22.708
#118	SMAD3	16	20	36	1601.544
#119	TEAD1	16	11	27	1529.592
#120	TCFL5	16	14	30	2723.61
#121	ZNF140	16	12	28	820.169
#122	CREM	16	11	27	1196.175
#123	NFYB	16	10	26	629.732
#124	E2F2	16	11	27	1082.275
#125	LHX3	16	6	22	502.532
#126	TSC22D2	16	12	28	1002.632
#127	NFX1	16	14	30	1234.347
#128	GLI2	16	12	28	1307.112
#129	ZXDA	16	5	21	612.052
#130	DLX3	16	10	26	779.915
#131	EN2	16	4	20	310.495
#132	IRF1	16	7	23	498.326
#133	L3MBTL4	15	4	19	162.663
#134	NR2F1	15	10	25	1489.808
#135	ZNF238	15	8	23	1837.224
#136	ZNF187	15	9	24	1752.815
#137	CREBL2	15	7	22	461.892
#138	CUX1	15	12	27	1772.472
#139	ZBTB38	15	10	25	1944.246
#140	TULP4	15	13	28	1155.018
#141	TRERF1	15	7	22	277.079
#142	TP73	15	13	28	693.962
#143	FOXR1	15	13	28	1046.307
#144	STAT6	15	9	24	813.815
#145	ZSCAN20	15	4	19	483.993
#146	HR	15	22	37	1518.033
#147	ZSCAN2	15	12	27	1211.56
#148	SIM2	15	14	29	1469.317
#149	MAX	15	14	29	1540.571
#150	RORB	15	3	18	172.037
#151	NFIA	15	14	29	1625.191
#152	TBX6	14	18	32	1140.618
#153	MECOM	14	6	20	228.062
#154	PLAGL2	14	11	25	612.899
#155	ELF3	14	17	31	1788.202
#156	E2F8	14	12	26	1280.802
#157	ZNF193	14	18	32	2057.398
#158	HNF4A	14	14	28	2714.371
#159	CCRN4L	14	6	20	888.275
#160	HOXA11	14	9	23	370.821
#161	KLF12	14	19	33	1627.33
#162	IRF5	14	14	28	2218.927
#163	GATAD2B	14	7	21	1438.917
#164	NR3C1	14	15	29	986.818
#165	HMGA2	14	15	29	1881.508
#166	ZSCAN10	14	12	26	1883.69
#167	RUNX2	14	6	20	630.739
#168	SOLH	14	13	27	771.913
#169	NFE2L1	14	7	21	1069.741
#170	THRA	13	21	34	752.668
#171	TMEM229A	13	10	23	298.761
#172	HIC1	13	12	25	853.12
#173	ZNF45	13	7	20	813.223
#174	ELK1	13	18	31	1815.818
#175	SREBF1	13	16	29	1827.858
#176	MEIS3P1	13	18	31	1618.529
#177	KLF16	13	16	29	1050.388
#178	SOX30	13	18	31	2393.001
#179	ZNF232	13	14	27	1099.237
#180	ATF6	13	12	25	905.62
#181	NME2	13	9	22	1379.622
#182	HOXB6	13	10	23	697.617
#183	DRAP1	13	13	26	1247.35
#184	HOXC13	13	18	31	1557.529
#185	MEIS3	12	15	27	1202.783
#186	GRHL3	12	14	26	937.902
#187	FUBP1	12	15	27	749.494
#188	TCF20	12	12	24	1985.123
#189	FOXJ3	12	13	25	1105.699
#190	TFCP2	12	5	17	789.526
#191	SMAD1	12	8	20	412.119
#192	SIX6	12	15	27	1056.136
#193	TRIM29	12	12	24	1670.168
#194	ETV6	12	10	22	581.135
#195	VSX1	12	19	31	1928.577
#196	LMO4	12	17	29	1299.292
#197	MAFA	12	11	23	490.951
#198	MAFK	12	17	29	1793.64
#199	ELF4	12	10	22	842.137
#200	RORA	12	15	27	661.346
#201	AEBP1	12	19	31	1813.154
#202	ZNF189	12	14	26	1089.307
#203	MYF6	12	13	25	1461.98
#204	PROX1	12	5	17	405.625
#205	BARX1	12	11	23	1432.352
#206	NFATC2	12	19	31	1062.273
#207	NFE2L3	12	12	24	1601.417
#208	BARHL1	12	10	22	1361.81
#209	ARNT2	11	15	26	1626.074
#210	KDM5B	11	16	27	644.832
#211	PBX1	11	8	19	873.586
#212	EHF	11	8	19	537.612
#213	FOXK1	11	13	24	1124.928
#214	NEUROD2	11	15	26	1048.542
#215	TBX19	11	5	16	341.655
#216	POU4F2	11	3	14	177.713
#217	NR4A3	11	7	18	521.521
#218	GSC2	11	18	29	1423.409
#219	NKX2-3	11	13	24	1463.302
#220	ZNF85	11	15	26	938.151
#221	LHX6	11	11	22	517.656
#222	ATF4	11	12	23	474.876
#223	DMRT1	11	15	26	727.602
#224	ZFHX2	11	11	22	1275.955
#225	CTCF	11	5	16	259.862
#226	ZFP42	11	14	25	989.275
#227	CNOT8	11	19	30	1475.104
#228	ZC3H8	11	14	25	539.306
#229	ETV4	11	13	24	987.497
#230	LASS6	11	7	18	409.688
#231	ZXDC	10	15	25	1420.072
#232	C5orf41	10	16	26	1163.39
#233	EGR4	10	18	28	579.954
#234	FOXD1	10	13	23	937.351
#235	HAND1	10	18	28	1025.402
#236	JUND	10	18	28	1225.519
#237	LHX1	10	12	22	630.449
#238	LHX2	10	12	22	342.81
#239	MGA	10	9	19	182.891
#240	MYT1	10	14	24	1506.216
#241	NFKB1	10	8	18	374.359
#242	OLIG2	10	17	27	1139.339
#243	SOX10	10	13	23	649.662
#244	SOX8	10	15	25	970.489
#245	ST18	10	9	19	572.45
#246	STAT5B	10	11	21	878.077
#247	USF2	10	5	15	1088.804
#248	ZNF219	10	15	25	611.038
#249	ZNF277	10	17	27	1535.928
#250	HOXC8	9	19	28	881.326
#251	BLZF1	9	10	19	364.056
#252	GCFC1	9	14	23	755.164
#253	ZNF70	9	19	28	781.947
#254	IRX2	9	14	23	613.635
#255	AFF4	9	9	18	363.858
#256	TWIST1	9	18	27	2371.24
#257	ZNF207	9	19	28	852.454
#258	KCNH8	9	20	29	668.357
#259	SMAD2	9	5	14	133.249
#260	SCRT2	9	16	25	1838.765
#261	ALX1	9	14	23	625.835
#262	ZIC5	9	15	24	552.691
#263	FOXE1	9	21	30	1314.326
#264	ZEB1	9	10	19	491.436
#265	SP140	9	12	21	641.923
#266	CTNNB1	9	8	17	385.758
#267	FOXC1	9	10	19	1803.627
#268	E4F1	9	14	23	2421.39
#269	AR	9	20	29	834.712
#270	HNRNPAB	9	12	21	644.942
#271	NR2F6	9	19	28	1820.479
#272	SOX2	9	13	22	494.943
#273	BTAF1	9	10	19	1466.246
#274	ETV3	9	11	20	1079.059
#275	RB1	9	18	27	1061.947
#276	TCF3	9	13	22	863.82
#277	RCOR1	9	14	23	534.314
#278	PPARD	8	15	23	508.369
#279	ETV7	8	20	28	859.52
#280	ZSCAN4	8	18	26	790.438
#281	ZBTB25	8	12	20	285.665
#282	ELK4	8	5	13	363.955
#283	ELF1	8	12	20	833.828
#284	ASCL1	8	20	28	771.374
#285	MYBL2	8	14	22	779.09
#286	ASCL2	8	14	22	1415.88
#287	ATF3	8	19	27	1254.879
#288	PFDN1	8	12	20	705.232
#289	BATF3	8	12	20	328.583
#290	PHTF1	8	11	19	990.033
#291	LEF1	8	16	24	1207.722
#292	NPAS2	8	8	16	390.058
#293	HOXC6	8	5	13	271.709
#294	HOPX	8	16	24	1194.013
#295	PKNOX1	8	18	26	1458.301
#296	SP4	8	16	24	820.036
#297	CREBBP	8	8	16	408.091
#298	NFKB2	8	12	20	426.473
#299	GRHL2	8	16	24	1352.702
#300	CTBP1	8	18	26	1958.891
#301	TAF4	8	11	19	378.216
#302	FOXO4	8	7	15	461.139
#303	TCF4	8	15	23	1515.089
#304	TCF7L2	8	12	20	563.419
#305	DMTF1	8	14	22	376.317
#306	FOXD4	8	12	20	615.122
#307	POU6F2	8	17	25	1105.298
#308	TFDP3	8	14	22	399.61
#309	ZBTB48	8	17	25	893.358
#310	ZNF19	7	19	26	954.322
#311	YY1	7	18	25	931.814
#312	PPARA	7	18	25	700.805
#313	NRL	7	21	28	2409.501
#314	FOS	7	16	23	971.357
#315	HIF3A	7	16	23	1190.57
#316	NOLC1	7	21	28	1590.656
#317	EMX1	7	17	24	646.23
#318	GATAD2A	7	22	29	1125.241
#319	ZFHX4	7	13	20	478.81
#320	TAL1	7	21	28	618.797
#321	FOXP2	7	18	25	652.018
#322	THRB	7	9	16	280.185
#323	TBX3	7	16	23	724.668
#324	FOXO3	7	5	12	88.782
#325	ONECUT2	7	18	25	770.506
#326	ESRRA	7	9	16	174.478
#327	RORC	7	13	20	629.599
#328	LHX5	7	15	22	1231.767
#329	ADNP2	7	15	22	485.743
#330	ATF7	7	19	26	915.143
#331	RHOXF2B	7	19	26	1703.609
#332	ZNF213	7	16	23	596.309
#333	ZNF449	7	16	23	1487.474
#334	ZNF202	7	14	21	793.685
#335	RCOR2	7	6	13	134.159
#336	MTA3	7	16	23	995.668
#337	MYC	7	14	21	381.037
#338	MYCN	7	11	18	488.522
#339	MYF5	7	12	19	432.999
#340	ZKSCAN4	7	15	22	749.856
#341	CREB3L2	7	15	22	653.619
#342	PCGF6	7	17	24	1512.718
#343	PAX3	6	21	27	1088.359
#344	TP53	6	11	17	607.216
#345	CBFB	6	13	19	1208.637
#346	TFDP1	6	21	27	1316.864
#347	ZEB2	6	8	14	550.762
#348	KLF15	6	18	24	686.507
#349	MYPOP	6	17	23	1107.726
#350	AFF1	6	16	22	1035.718
#351	SCML1	6	12	18	318.519
#352	SOX9	6	15	21	413.727
#353	FBXW7	6	7	13	544.402
#354	TBX4	6	17	23	547.763
#355	RELB	6	16	22	507.664
#356	NFYA	6	15	21	504.106
#357	USF1	6	14	20	521.271
#358	FOXJ2	6	21	27	988.13
#359	FOXL1	6	18	24	368.05
#360	CRX	6	18	24	688.738
#361	UBN1	6	20	26	1508.463
#362	TCF21	6	16	22	467.157
#363	SIX3	6	15	21	790.971
#364	NR1H2	6	16	22	277.47
#365	PITX1	6	14	20	335.26
#366	E2F1	6	14	20	669.136
#367	PGR	6	16	22	349.136
#368	FOXD3	6	12	18	564.643
#369	KLF7	5	20	25	376.873
#370	MYT1L	5	17	22	437.798
#371	MYOG	5	8	13	120.681
#372	RHOXF1	5	16	21	692.704
#373	MITF	5	12	17	1084.797
#374	LHX9	5	19	24	318.92
#375	KLF3	5	17	22	351.23
#376	SP1	5	14	19	225.384
#377	HNF1A	5	14	19	541.568
#378	HMGB1	5	14	19	661.328
#379	SUPT4H1	5	18	23	394.369
#380	FOXM1	5	11	16	269.09
#381	TFAM	5	22	27	1241.358
#382	TFAP2E	5	6	11	397.986
#383	TFDP2	5	11	16	292.804
#384	FOXD2	5	17	22	509.497
#385	FOXA1	5	12	17	349.48
#386	FOSB	5	19	24	572.134
#387	EVX1	5	20	25	2164.007
#388	ZNF148	5	14	19	694.93
#389	ZNF167	5	12	17	388.311
#390	ZNF236	5	17	22	346.866
#391	ZNF35	5	14	19	770.885
#392	ZNF444	5	22	27	512.532
#393	NFATC4	4	15	19	263.04
#394	FOXI3	4	21	25	768.831
#395	BRD8	4	12	16	287.406
#396	RAX2	4	17	21	1195.583
#397	MLXIPL	4	15	19	538.996
#398	HOXD9	4	18	22	1655.402
#399	IRX5	4	15	19	439.699
#400	FOXG1	4	13	17	576.841
#401	ZHX2	4	14	18	255.402
#402	ZIC1	4	19	23	795.757
#403	SPI1	4	14	18	234.057
#404	FOXJ1	4	14	18	712.179
#405	CDKN2A	4	15	19	386.695
#406	SOX6	4	14	18	426.188
#407	TLX2	4	20	24	661.162
#408	ZSCAN16	4	21	25	596.924
#409	ZNF165	4	19	23	570.266
#410	C1orf85	4	19	23	316.924
#411	PPARG	3	15	18	186.394
#412	TCF7	3	23	26	1820.213
#413	STAT3	3	19	22	251.789
#414	CREB3L4	3	20	23	378.465
#415	SOX7	3	16	19	873.215
#416	HOXA9	3	19	22	482.198
#417	POU3F4	3	20	23	638.367
#418	BCL3	3	12	15	173.94
#419	ZNF24	3	8	11	165.218
#420	ZNF256	3	14	17	384.185
#421	PAX6	3	20	23	720.191
#422	BACH1	3	15	18	361.973
#423	ZNF438	3	17	20	343.208
#424	NR0B1	3	21	24	331.535
#425	RFXANK	3	12	15	480.714
#426	ZNF483	3	21	24	752.489
#427	PURB	3	18	21	396.563
#428	VAV1	3	17	20	463.09
#429	ESR1	3	19	22	209.489
#430	SUPT6H	2	19	21	221.676
#431	SPIB	2	18	20	659.773
#432	RNF4	2	19	21	224.645
#433	MSX2	2	16	18	503.53
#434	VDR	2	28	30	291.209
#435	POU3F2	2	26	28	842.695
#436	MLX	2	18	20	331.344
#437	MTA1	2	11	13	145.97
#438	ARNTL	2	16	18	185.396
#439	ZNF37A	2	18	20	119.783
#440	SOX12	2	21	23	343.524
#441	LCOR	2	17	19	168.189
#442	HMG20A	1	23	24	218.329
#443	IRX3	1	19	20	969.586
#444	ATF2	1	22	23	51.684
#445	RELA	1	18	19	148.86
#446	HOXD13	1	15	16	31.408
#447	ZNF33A	0	17	17	0