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Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	MAFA	56	1	57	500.229
#2	TEF	37	5	42	679.819
#3	ARNTL2	35	9	44	1525.635
#4	PURB	35	3	38	735.99
#5	ELF1	34	6	40	837.001
#6	ZFP36L1	32	6	38	474.069
#7	SOX12	31	4	35	1430.437
#8	TP63	31	7	38	1586.127
#9	HNF1B	30	5	35	506.137
#10	PAX8	30	7	37	1384.229
#11	PITX1	29	11	40	3008.193
#12	CSRNP3	29	5	34	1939.939
#13	RNF4	29	8	37	2049.639
#14	NFYC	27	9	36	1440.605
#15	FOXO4	27	3	30	1461.217
#16	FOXM1	26	3	29	422.861
#17	SP4	25	3	28	92.801
#18	CUX1	25	9	34	1378.922
#19	ZNF165	24	8	32	1515.568
#20	SNAPC4	24	7	31	914.657
#21	KLF12	24	7	31	409.585
#22	ESRRB	23	7	30	1050.086
#23	HIF1A	23	4	27	1302.518
#24	SMAD9	22	9	31	790.671
#25	NR0B1	22	2	24	321.524
#26	EN1	22	5	27	451.867
#27	DMRT1	21	10	31	2335.607
#28	TFDP3	21	9	30	1267.634
#29	ELK4	21	7	28	1164.846
#30	MXD1	21	9	30	1202.889
#31	ZSCAN20	21	4	25	567.584
#32	LHX6	20	11	31	909.314
#33	PRDM1	20	4	24	377.711
#34	MEIS1	20	11	31	1795.809
#35	JUN	20	9	29	1382.383
#36	ZNF81	20	8	28	1074.394
#37	HOXC8	20	15	35	2980.857
#38	AFF1	20	10	30	1632.326
#39	GATAD2A	20	10	30	1021.155
#40	CBFB	20	8	28	1091.484
#41	HIF3A	20	9	29	1363.084
#42	IRX1	19	9	28	2340.809
#43	NFIB	19	4	23	316.498
#44	MYOG	19	2	21	84.666
#45	OLIG2	19	8	27	699.433
#46	HOXC6	19	15	34	2541.27
#47	STRN3	19	2	21	915.602
#48	TCFL5	19	13	32	1272.176
#49	E2F2	19	7	26	964.679
#50	FOXJ1	19	14	33	1367.586
#51	ASCL1	19	11	30	1794.624
#52	TP73	19	3	22	424.541
#53	BARHL1	18	9	27	940.18
#54	SOLH	18	11	29	1458.31
#55	SMAD5	18	3	21	996.026
#56	XBP1	18	7	25	1212.341
#57	TFAP2A	18	7	25	910.685
#58	BTAF1	18	8	26	633.61
#59	TWIST1	18	11	29	1711.069
#60	IRF1	18	9	27	531.213
#61	NFYB	17	11	28	2309.146
#62	RB1	17	8	25	1299.576
#63	MYC	17	10	27	1002.916
#64	CTNNB1	17	10	27	1635.944
#65	RARA	17	7	24	2009.103
#66	RCOR1	17	4	21	801.833
#67	TCF21	17	5	22	587.235
#68	NOLC1	17	11	28	1234.502
#69	GATA2	17	6	23	866.615
#70	ZNF85	17	3	20	191.008
#71	ASCL2	17	11	28	2347.524
#72	PCGF6	17	12	29	2008.25
#73	TRIM29	17	2	19	316.041
#74	RUNX2	17	12	29	2316.743
#75	ZFPM1	17	8	25	1086.543
#76	ETV7	16	8	24	1220.979
#77	NR3C1	16	10	26	2305.333
#78	DLX3	16	9	25	1465.561
#79	ESRRA	16	5	21	464.757
#80	THRA	16	9	25	1218.482
#81	ATF6B	16	4	20	875.648
#82	HDAC1	16	9	25	1277.202
#83	HMGA1	16	12	28	1234.47
#84	HMGA2	16	7	23	608.631
#85	HOXB7	16	2	18	200.335
#86	HOXD9	16	13	29	1079.412
#87	IRX2	16	8	24	1139.187
#88	SRF	16	10	26	1441.04
#89	SMAD2	16	12	28	1362.904
#90	MYBL2	16	9	25	2245.519
#91	MYF5	16	8	24	901.653
#92	REL	16	7	23	484.869
#93	PLAGL2	15	10	25	1299.108
#94	ZKSCAN4	15	9	24	696.469
#95	ADNP2	15	8	23	1004.932
#96	HIC1	15	11	26	1070.394
#97	NFX1	15	8	23	717.257
#98	RUNX1T1	15	11	26	2048.491
#99	NR4A3	15	7	22	571.717
#100	HOXA11	15	11	26	818.929
#101	ETV6	15	9	24	907.16
#102	BATF3	15	2	17	361.541
#103	LASS6	15	7	22	1679.006
#104	ZIC5	15	7	22	435.68
#105	WNT5A	15	9	24	1165.712
#106	NFE2L1	15	11	26	1624.124
#107	ZNF438	15	12	27	1212.016
#108	USF1	15	10	25	788.081
#109	NFKB1	14	1	15	159.117
#110	IRX4	14	13	27	1556.96
#111	PRRX1	14	7	21	863.258
#112	FOXJ3	14	14	28	1312.453
#113	TFAP2E	14	10	24	820.042
#114	E2F8	14	3	17	494.566
#115	RORA	14	13	27	1632.116
#116	GRHL2	14	10	24	1554.566
#117	POU6F2	14	15	29	1502.023
#118	ZNF24	14	9	23	1211.665
#119	ZNF238	14	6	20	493.281
#120	ZXDC	14	8	22	687.649
#121	LEF1	14	13	27	823.671
#122	L3MBTL4	14	9	23	922.055
#123	KLF16	14	14	28	1226.435
#124	FOXE1	13	10	23	549.255
#125	SPI1	13	7	20	859.685
#126	ZSCAN2	13	9	22	1171.236
#127	DLX1	13	10	23	1307.713
#128	NR2F6	13	10	23	1264.585
#129	TSC22D3	13	12	25	916.171
#130	TSC22D1	13	5	18	1010.041
#131	PHTF1	13	7	20	726.949
#132	PROX1	13	3	16	245.693
#133	FOXL1	13	6	19	770.929
#134	HOXB6	13	12	25	1501.693
#135	TBP	13	12	25	1602.214
#136	ZFPM2	13	13	26	2256.098
#137	ZNF193	13	11	24	1446.822
#138	ELK1	13	11	24	1553.926
#139	NR1D1	13	7	20	978.958
#140	GATAD2B	13	13	26	2247.239
#141	TGIF2LY	13	9	22	1078.505
#142	CTCF	13	7	20	608.314
#143	GLIS3	13	13	26	958.205
#144	CITED2	13	18	31	1786.058
#145	HOXC13	13	6	19	432.888
#146	FOXI3	13	13	26	847.672
#147	SMAD3	13	12	25	1415.629
#148	YY1	12	14	26	1889.825
#149	ZNF70	12	15	27	1965.78
#150	TFDP2	12	6	18	557.558
#151	DMRT2	12	7	19	714.197
#152	GCFC1	12	13	25	1602.392
#153	TCF4	12	11	23	1238.199
#154	HNF4A	12	11	23	997.353
#155	STAT2	12	11	23	1279.05
#156	ZNF35	12	6	18	430.058
#157	AR	12	14	26	734.416
#158	ZNF277	12	15	27	1398.562
#159	SOX11	12	10	22	1002.155
#160	ALX1	12	10	22	1039.076
#161	PGR	12	12	24	1736.562
#162	MECOM	12	11	23	1852.773
#163	NOTCH1	12	7	19	344.679
#164	NME2	12	12	24	1445.249
#165	NR2E3	12	14	26	1379.544
#166	TRIM25	12	14	26	1856.267
#167	EVX1	12	10	22	1029.223
#168	TLX2	12	11	23	1049.603
#169	MNT	11	12	23	1024.81
#170	SOX8	11	13	24	886.19
#171	TCF7	11	14	25	1322.782
#172	SOX17	11	9	20	982.655
#173	GLI2	11	10	21	732.701
#174	LHX1	11	3	14	352.813
#175	FOXD1	11	14	25	1333.442
#176	HNRNPAB	11	8	19	660.002
#177	FOXD3	11	5	16	1688.174
#178	LHX3	11	6	17	794.211
#179	MEIS3P1	11	11	22	1501.249
#180	FOXP2	11	11	22	904.37
#181	NR2C1	11	9	20	675.354
#182	ZKSCAN1	11	10	21	1127.578
#183	IRF4	11	4	15	91.244
#184	MGA	11	5	16	385.993
#185	TRERF1	11	10	21	687.102
#186	ST18	11	14	25	1071.484
#187	HSF2	11	18	29	1565.818
#188	MITF	11	7	18	846.376
#189	CREB3L3	11	11	22	735.304
#190	STAT5B	11	9	20	1202.727
#191	TBX5	11	13	24	778.579
#192	TFCP2	11	12	23	1262.931
#193	CREB3L2	11	9	20	456.102
#194	EGR2	11	9	20	611.592
#195	RBPJ	10	8	18	1184.027
#196	NFIA	10	13	23	1915.53
#197	BARX1	10	6	16	444.043
#198	JUND	10	11	21	837.373
#199	KDM5B	10	7	17	1031.848
#200	ONECUT2	10	7	17	625.945
#201	HOXB3	10	9	19	716.718
#202	HOXA4	10	9	19	606.317
#203	ZNF219	10	9	19	401.126
#204	TAF4	10	7	17	403.684
#205	LHX4	10	8	18	815.087
#206	TFAM	10	10	20	1411.837
#207	ZXDA	10	15	25	1040.444
#208	ZNF256	10	14	24	2136.761
#209	SNAPC5	10	7	17	605.58
#210	TBX6	10	6	16	299.501
#211	MEIS3	10	11	21	882.145
#212	ZEB2	10	8	18	478.657
#213	NEUROD2	10	16	26	1160.525
#214	ZNF19	10	10	20	1281.681
#215	GTF2I	10	11	21	1099.868
#216	EHF	10	16	26	2194.913
#217	MSX2	10	10	20	1238.473
#218	TCF7L1	10	11	21	1181.656
#219	ZSCAN10	10	10	20	1403.941
#220	FUBP1	10	9	19	1315.386
#221	MYCN	10	11	21	894.868
#222	MYF6	10	11	21	905.61
#223	MYT1L	10	9	19	1055.168
#224	FOSL1	10	16	26	2054.343
#225	STAT1	10	12	22	1966.931
#226	ZC3H8	9	11	20	1028.751
#227	ATF6	9	13	22	1348.128
#228	BRD8	9	7	16	768.853
#229	BTG2	9	6	15	426.343
#230	C5orf41	9	10	19	835.834
#231	CREB1	9	16	25	1369.112
#232	CSDA	9	11	20	733.879
#233	CTBP1	9	17	26	926.587
#234	DDIT3	9	14	23	1282.532
#235	DMTF1	9	14	23	810.07
#236	ELF4	9	15	24	1150.287
#237	EN2	9	8	17	495.763
#238	FOS	9	7	16	354.136
#239	FOXA3	9	17	26	2052.239
#240	FOXD2	9	7	16	292.927
#241	FOXG1	9	14	23	1483.314
#242	HAND1	9	12	21	689.306
#243	HOXA9	9	16	25	810.904
#244	IRF5	9	8	17	556.624
#245	IRX3	9	17	26	1586.519
#246	JUNB	9	14	23	832.836
#247	LHX2	9	6	15	546.741
#248	LHX5	9	9	18	588.878
#249	MAFK	9	8	17	914.961
#250	NFATC4	9	15	24	1171.723
#251	NFIX	9	10	19	983.434
#252	NFYA	9	8	17	476.391
#253	PAX3	9	15	24	1396.363
#254	POU4F2	9	9	18	1189.202
#255	RHOXF2	9	9	18	687.978
#256	RORC	9	10	19	433.299
#257	RUNX1	9	10	19	790.724
#258	SIM2	9	10	19	863.636
#259	SMAD4	9	14	23	1082.231
#260	SOX4	9	10	19	315.679
#261	SOX6	9	10	19	1879.969
#262	SP1	9	6	15	353.04
#263	SUPT6H	9	10	19	741.976
#264	TCF7L2	9	9	18	721.958
#265	TFEC	9	15	24	1063.849
#266	USF2	9	5	14	550.19
#267	ZNF449	9	14	23	812.124
#268	ZNF45	9	8	17	660.422
#269	HNRNPK	8	11	19	816.529
#270	ZNF187	8	8	16	514.793
#271	NR2F1	8	12	20	1327.665
#272	VDR	8	19	27	1848.735
#273	RHOXF2B	8	14	22	923.862
#274	NFE2L3	8	13	21	1180.422
#275	ESR2	8	11	19	863.862
#276	PKNOX1	8	11	19	382.801
#277	ZEB1	8	10	18	1208.887
#278	BLZF1	8	11	19	1345.415
#279	PBX1	8	15	23	908.695
#280	PBX3	8	13	21	668.395
#281	SOX10	8	5	13	456.839
#282	CREB3L4	8	13	21	753.073
#283	SPDEF	8	16	24	923.626
#284	KLF15	8	6	14	768.649
#285	CREBL2	8	12	20	1200.315
#286	ZSCAN29	8	9	17	338.075
#287	GRHL3	8	11	19	663.754
#288	NKX2-1	8	12	20	971.008
#289	SOX7	8	12	20	623.033
#290	CREBBP	8	11	19	766.909
#291	BACH1	8	14	22	832.864
#292	CEBPA	8	18	26	1449.131
#293	DRAP1	8	9	17	325.84
#294	RXRA	8	9	17	353.663
#295	CDKN2A	8	12	20	974.127
#296	ZNF232	8	13	21	527.488
#297	ATF3	8	14	22	944.364
#298	TP53	7	16	23	1081.112
#299	ETV3	7	19	26	926.472
#300	ETS2	7	13	20	595.016
#301	TSC22D2	7	12	19	693.63
#302	ELF3	7	18	25	1373.732
#303	EGR4	7	13	20	1132.486
#304	E4F1	7	16	23	1282.646
#305	E2F1	7	17	24	805.185
#306	MYT1	7	12	19	827.013
#307	PPARG	7	13	20	1889.774
#308	RORB	7	7	14	506.303
#309	NPAS2	7	10	17	905.734
#310	MTA1	7	11	18	764.476
#311	AFF4	7	13	20	883.16
#312	POU3F2	7	15	22	1533.142
#313	POU2F2	7	11	18	915.085
#314	PAX6	7	13	20	854.349
#315	NFIL3	7	10	17	332.089
#316	LHX9	7	15	22	975.026
#317	SOX2	7	11	18	1058.238
#318	ZNF444	7	13	20	968.409
#319	ARNTL	7	15	22	920.888
#320	ZNF37A	7	11	18	508.889
#321	ZSCAN18	7	13	20	1240.286
#322	IRX5	7	13	20	969.902
#323	ZNF236	7	19	26	1099.509
#324	ARNT2	7	17	24	1369.786
#325	TBX19	7	11	18	820.876
#326	TBX3	7	16	23	840.857
#327	RELA	7	18	25	1077.485
#328	RELB	7	16	23	1555.937
#329	GSC2	7	17	24	1032.679
#330	RFXANK	7	16	23	1212.541
#331	ARNT	7	11	18	571.271
#332	ZNF174	7	11	18	642.858
#333	FOXD4	7	12	19	1158.205
#334	FOXC1	7	11	18	1274.894
#335	ZIC1	7	14	21	759.971
#336	C1orf85	6	9	15	292.728
#337	FOXK1	6	16	22	916.546
#338	SCRT2	6	9	15	413.805
#339	NFATC2	6	14	20	677.177
#340	HNF1A	6	11	17	788.431
#341	CNOT8	6	13	19	582.267
#342	ZKSCAN2	6	7	13	149.86
#343	ETV4	6	18	24	1183.411
#344	SCML1	6	12	18	793.384
#345	NFKB2	6	11	17	1655.854
#346	ZNF213	6	20	26	821.789
#347	RHOXF1	6	12	18	654.564
#348	RAX2	6	15	21	776.429
#349	ZBTB25	6	14	20	1282.542
#350	FOXA1	6	12	18	509.189
#351	POU5F2	6	12	18	927.329
#352	TULP4	6	20	26	1272.55
#353	AEBP1	6	17	23	1256.282
#354	TEAD1	6	12	18	805.334
#355	THRB	6	7	13	284.5
#356	ZSCAN16	6	17	23	1586.522
#357	PFDN1	6	10	16	483.872
#358	LCOR	6	12	18	866.689
#359	KCNH8	6	16	22	1263.512
#360	SPIB	6	15	21	501.386
#361	SREBF1	6	16	22	1296.131
#362	FOXO3	6	11	17	506.601
#363	IKZF1	6	13	19	736.873
#364	ZNF33A	6	17	23	1332.021
#365	MLL	6	14	20	734.546
#366	MLXIPL	6	11	17	228.577
#367	HOXA10	6	15	21	466.037
#368	SIX6	6	19	25	1265.544
#369	ZNF140	6	14	20	1034.958
#370	KLF7	5	19	24	921.978
#371	NKX2-3	5	16	21	849.432
#372	RAX	5	15	20	613.346
#373	RBPJL	5	9	14	284.364
#374	ATF4	5	16	21	1055.364
#375	MTA3	5	17	22	1428.419
#376	SALL2	5	14	19	557.042
#377	MLLT10	5	16	21	706.866
#378	SP140	5	8	13	243.354
#379	STAT3	5	13	18	1397.871
#380	STAT6	5	16	21	789.108
#381	TAL1	5	14	19	284.105
#382	TBX4	5	15	20	705.789
#383	HCFC1	5	14	19	889.103
#384	GSC	5	19	24	895.419
#385	EMX1	5	15	20	646.24
#386	VAV1	5	13	18	405.755
#387	VSX1	5	12	17	343.392
#388	ZFHX4	5	18	23	615.502
#389	ZHX2	5	14	19	798.868
#390	ZNF167	5	13	18	717.87
#391	ZNF202	5	16	21	833.41
#392	BCL3	5	8	13	257.952
#393	SMAD1	4	19	23	889.643
#394	ATF2	4	16	20	270.512
#395	LMO4	4	13	17	454.636
#396	ZNF207	4	16	20	532.326
#397	CRX	4	16	20	745.338
#398	HMG20A	4	18	22	1198.563
#399	NR1H2	4	15	19	1195.05
#400	SUPT4H1	4	11	15	390.872
#401	PPARA	4	10	14	389.336
#402	ELF5	4	17	21	540.103
#403	ZBTB38	4	15	19	597.508
#404	CREB3L1	4	13	17	385.183
#405	ZFP42	4	14	18	475.288
#406	FOXJ2	4	7	11	208.908
#407	FOXK2	4	16	20	621.115
#408	POU3F4	4	12	16	1364.388
#409	ZSCAN4	4	13	17	333.399
#410	PPARD	4	8	12	251.851
#411	FOXR1	4	14	18	283.54
#412	GABPB1	4	16	20	586.002
#413	CEBPB	4	12	16	489.358
#414	SIX3	3	17	20	416.003
#415	NRL	3	19	22	862.104
#416	CREBZF	3	9	12	254.205
#417	TMEM229A	3	12	15	432.888
#418	FOSB	3	15	18	397.346
#419	TFDP1	3	12	15	426.31
#420	CNOT7	3	21	24	800.197
#421	TCF20	3	10	13	208.5
#422	CCRN4L	3	8	11	976.115
#423	HOPX	3	12	15	622.959
#424	HOXD13	3	12	15	336.155
#425	HR	3	15	18	437.019
#426	SOX9	3	7	10	221.092
#427	ZNF397	3	17	20	451.381
#428	ZNF445	3	14	17	303.955
#429	MAX	3	16	19	656.588
#430	ZBTB48	3	12	15	303.559
#431	ATF7	2	19	21	713.509
#432	ZFHX2	2	14	16	448.266
#433	HMGB1	2	15	17	237.559
#434	UBN1	2	15	17	162.505
#435	SOX30	2	9	11	270.588
#436	CREM	2	10	12	250.031
#437	MLX	2	14	16	147.186
#438	TCF3	2	17	19	723.132
#439	MNX1	2	13	15	180.966
#440	ZNF189	2	14	16	150.157
#441	FBXW7	2	12	14	337.47
#442	RCOR2	2	14	16	552.401
#443	ZNF483	2	15	17	185.726
#444	ESR1	2	14	16	387.669
#445	KLF3	2	16	18	477.474
#446	MYPOP	1	15	16	155.156
#447	ZNF148	1	13	14	42.957