Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	ZEB2	36	2	38	244.76
#2	MAFB	33	6	39	385.34
#3	TAF4	31	2	33	1487.203
#4	AEBP1	29	3	32	446.007
#5	MITF	29	3	32	1584.701
#6	GTF2I	29	3	32	959.938
#7	HOXB2	29	6	35	6602.397
#8	TCF4	28	3	31	1590.488
#9	ARID3A	28	8	36	2473.003
#10	MEIS1	27	6	33	1932.666
#11	NR1I2	27	7	34	895.017
#12	HNF1A	26	7	33	447.765
#13	TCFL5	26	3	29	440.83
#14	KLF2	25	6	31	232.596
#15	PRRX1	25	9	34	347.557
#16	SNAI2	25	6	31	228.173
#17	HCLS1	25	6	31	1038.42
#18	CDX2	25	10	35	4743.594
#19	PLAGL2	24	2	26	44.867
#20	HAND1	23	6	29	1596.058
#21	GAS7	23	2	25	45.689
#22	TRIM22	23	8	31	1095.999
#23	CBFA2T3	23	7	30	1136.362
#24	FOXF1	22	7	29	470.105
#25	CUX1	22	8	30	2340.593
#26	ZFPM2	22	7	29	1521.827
#27	TEAD4	22	8	30	2817.563
#28	LMO4	22	3	25	488.302
#29	ZNF268	22	6	28	2018.577
#30	PBX3	21	6	27	325.462
#31	MECOM	21	6	27	1083.768
#32	FOXM1	21	7	28	1083.172
#33	ZNF165	21	13	34	3404.978
#34	BCL6	20	10	30	2660.842
#35	FOXN3	20	6	26	525.871
#36	NR3C1	20	10	30	512.504
#37	FLI1	19	7	26	300.601
#38	RUNX1T1	19	6	25	417.705
#39	TCF3	19	7	26	1620.268
#40	MTA2	19	4	23	862.497
#41	BHLHE41	19	10	29	743.254
#42	SATB2	18	7	25	1117.844
#43	NANOG	18	7	25	1377.445
#44	FOXA2	18	12	30	1813.069
#45	CREB3L1	18	12	30	1422.276
#46	FOSL2	18	10	28	1379.351
#47	HR	18	12	30	1636.4
#48	STRN3	18	9	27	1193.123
#49	RORA	18	11	29	1600.349
#50	ZNF132	18	10	28	1943.257
#51	SP1	18	5	23	807.514
#52	MEIS2	18	11	29	744.065
#53	PRDM1	17	8	25	605.74
#54	TWIST1	17	4	21	298.455
#55	ATOH1	17	10	27	1377.939
#56	ZBTB25	17	6	23	1902.191
#57	TFAP2A	17	14	31	3918.391
#58	MNX1	17	7	24	427.945
#59	HOPX	17	10	27	800.426
#60	NR1D2	17	7	24	523.947
#61	PLSCR1	17	7	24	628.184
#62	SOX9	17	9	26	885.815
#63	NFIC	17	7	24	5225.94
#64	YEATS4	17	9	26	1038.758
#65	PAX5	16	11	27	1799.108
#66	SPDEF	16	6	22	1108.186
#67	MAX	16	8	24	1857.079
#68	E2F8	16	7	23	1266.408
#69	NR6A1	16	8	24	1801.002
#70	KLF9	16	13	29	844.89
#71	PPARG	16	11	27	1029.796
#72	HMGA2	16	12	28	1362.706
#73	TAL1	16	13	29	1931.96
#74	SOX4	16	13	29	2741.7
#75	CSDA	15	13	28	1350.228
#76	SOX10	15	10	25	2175.349
#77	ZNF80	15	10	25	2258.31
#78	HEYL	15	11	26	2007.498
#79	TFDP3	15	5	20	580.042
#80	ETV4	15	8	23	488.362
#81	CEBPE	15	9	24	1580.806
#82	MYBL2	15	7	22	461.408
#83	ZNF444	15	15	30	2748.805
#84	NFX1	15	9	24	840.109
#85	NR2E3	15	6	21	404.494
#86	NR4A2	15	8	23	1143.38
#87	C11orf9	14	9	23	1195.588
#88	NR3C2	14	11	25	941.852
#89	CITED2	14	10	24	1336.451
#90	ENO1	14	9	23	1467.234
#91	GABPA	14	13	27	2007.213
#92	EGR2	14	7	21	153.219
#93	ZNF287	14	14	28	2119.545
#94	NFIB	14	11	25	1522.764
#95	BRD8	14	5	19	1254.063
#96	GLI3	14	7	21	4922.263
#97	TFAP4	14	8	22	1418.806
#98	JUN	14	14	28	2151.478
#99	NKX3-2	14	9	23	1091.001
#100	ZFP36L2	14	13	27	1121.645
#101	HOXA10	14	4	18	313.366
#102	ETS2	14	11	25	1493.934
#103	CEBPA	14	8	22	295.34
#104	ZNF446	14	13	27	2023.009
#105	TCF7	14	9	23	799.208
#106	ZNF238	14	11	25	1503.353
#107	ZNF236	14	11	25	3131.325
#108	MGA	14	9	23	501.885
#109	PROX1	14	9	23	1510.161
#110	ZSCAN18	14	11	25	890.24
#111	NKX2-5	13	10	23	1235.62
#112	E2F5	13	9	22	922.907
#113	RXRB	13	12	25	1193.736
#114	PITX1	13	17	30	2499.8
#115	ISL1	13	10	23	854.562
#116	IRF8	13	9	22	1145.761
#117	HOXB7	13	4	17	327.729
#118	ZNF323	13	12	25	1492.926
#119	TGIF2	13	9	22	892.112
#120	MEF2C	13	11	24	1022.887
#121	PTTG1	13	10	23	1256.199
#122	BUD31	13	11	24	2011.818
#123	ETV5	13	10	23	1460.919
#124	ALS2CR8	13	4	17	778.067
#125	HOXA5	13	2	15	92.509
#126	MSRB2	13	14	27	1876.732
#127	GABPB1	13	9	22	1323.229
#128	BHLHE40	13	11	24	1759.734
#129	HOXD10	13	7	20	1014.788
#130	TP73	13	9	22	2715.813
#131	ZEB1	13	13	26	2759.585
#132	AR	13	9	22	1648.853
#133	ETV1	13	11	24	1139.866
#134	DBP	13	9	22	660.982
#135	SALL1	13	7	20	1205.065
#136	TRPS1	13	10	23	679.864
#137	FOS	13	8	21	1509.235
#138	ZHX3	13	9	22	2862.844
#139	ZBTB38	13	12	25	1643.518
#140	PKNOX2	13	10	23	1137.46
#141	SLC26A3	12	13	25	1355.095
#142	HOXA9	12	9	21	1024.506
#143	ESRRG	12	17	29	2100.709
#144	MAF	12	10	22	851.229
#145	NFAT5	12	6	18	1370.3
#146	MLL	12	10	22	1426.645
#147	HEY1	12	11	23	876.401
#148	EN1	12	13	25	1538.456
#149	SIM2	12	13	25	1513.854
#150	TCF12	12	15	27	2250.141
#151	KLF4	12	13	25	701.998
#152	BLZF1	12	9	21	1144.646
#153	EGR3	12	9	21	1446.12
#154	POU6F2	12	9	21	845.977
#155	CTNNB1	12	4	16	262.482
#156	MYT1	12	10	22	1063.609
#157	ZNF643	12	13	25	2120.883
#158	BNC1	12	9	21	1375.012
#159	PRRX2	12	9	21	550.673
#160	RBCK1	12	15	27	1764.917
#161	FOXF2	12	5	17	635.367
#162	TBR1	12	6	18	878.615
#163	HOXA3	12	11	23	1434.398
#164	KDM5A	12	12	24	2060.788
#165	SOX18	12	10	22	2184.961
#166	ELF3	12	15	27	596.296
#167	RORC	12	12	24	1503.303
#168	NR1H3	12	10	22	875.21
#169	ELF4	11	13	24	1776.091
#170	RARB	11	9	20	1622.058
#171	POU5F1B	11	14	25	1135.72
#172	HIC1	11	9	20	1151.197
#173	HES1	11	10	21	1352.46
#174	ZNF175	11	8	19	1507.22
#175	IRF7	11	9	20	1041.165
#176	NFATC1	11	6	17	892.927
#177	ZNF500	11	9	20	939.965
#178	ZFHX3	11	6	17	737.446
#179	TCF21	11	3	14	45.217
#180	SATB1	11	12	23	1542.694
#181	FOXD2	11	13	24	1400.384
#182	ZSCAN16	11	6	17	1528.074
#183	KLF15	11	6	17	998.02
#184	FOXL2	11	8	19	1064.775
#185	POU3F4	11	12	23	1781.535
#186	POU4F1	11	11	22	1092.728
#187	HNF1B	11	11	22	1306.844
#188	T	11	11	22	1630.53
#189	ZNF232	11	10	21	2147.799
#190	CBFA2T2	11	11	22	1694.59
#191	NPAS1	11	12	23	2190.3
#192	NR0B1	11	8	19	1256.494
#193	SMAD4	11	11	22	1908.275
#194	NFATC3	11	9	20	1210.851
#195	KLF5	11	7	18	418.32
#196	NFATC4	11	12	23	890.833
#197	SIX5	11	6	17	746.432
#198	SMAD5	11	11	22	928.791
#199	NFE2	11	10	21	1689.196
#200	MSX2	11	14	25	2159.99
#201	GBX2	11	11	22	1386.549
#202	MYCN	11	10	21	1088.246
#203	HOXA7	11	8	19	542.173
#204	VENTX	11	7	18	865.787
#205	HNF4G	11	11	22	791.691
#206	ZNF434	11	8	19	1641.977
#207	PBX1	10	11	21	1630.124
#208	E2F1	10	10	20	448.819
#209	NR2F6	10	10	20	1528.38
#210	RUNX3	10	7	17	285.172
#211	ZGPAT	10	15	25	1408.29
#212	ZNF117	10	9	19	686.848
#213	ELK1	10	14	24	2138.761
#214	RXRA	10	9	19	2065.621
#215	SCAND2	10	14	24	2320.862
#216	ASCL2	10	15	25	1452.352
#217	TFEC	10	3	13	39.276
#218	SOX13	10	5	15	2892.027
#219	NFE2L3	10	8	18	406.033
#220	PAX7	10	12	22	1541.447
#221	TAF12	10	7	17	1277.886
#222	ZFP37	10	9	19	1061.308
#223	CREM	10	15	25	1597.65
#224	FOXH1	10	15	25	2648.623
#225	MAFK	10	12	22	1449.771
#226	MYOG	10	11	21	822.841
#227	STAT6	10	11	21	962.738
#228	ALX1	10	8	18	662.38
#229	KLF6	10	13	23	872.516
#230	SOX15	10	6	16	1256.796
#231	LZTS1	10	12	22	1622.978
#232	VDR	10	8	18	1261.069
#233	EGR1	10	7	17	722.256
#234	ARNT	10	11	21	1533.618
#235	ELK3	10	8	18	1110.139
#236	ESR2	10	12	22	1067.899
#237	HMBOX1	10	8	18	1681.979
#238	HOXB9	9	13	22	891.623
#239	FOXO4	9	11	20	999.387
#240	RORB	9	5	14	364.016
#241	STAT2	9	10	19	1294.169
#242	RBPJL	9	7	16	687.089
#243	PDX1	9	13	22	1628.397
#244	MZF1	9	17	26	1423.15
#245	MMP14	9	12	21	833.663
#246	ZSCAN2	9	13	22	949.669
#247	HOXA4	9	7	16	769.112
#248	HOXA2	9	17	26	1334.441
#249	HAND2	9	11	20	833.015
#250	HOXB6	9	10	19	1079.669
#251	HOXB8	9	10	19	1024.188
#252	TSC22D2	9	10	19	1182.631
#253	ZSCAN12	9	7	16	1716.006
#254	ONECUT2	9	8	17	723.304
#255	PPARD	9	11	20	1435.858
#256	NFIX	9	12	21	1042.103
#257	ARNTL	9	13	22	1498.626
#258	NPAS2	9	10	19	398.546
#259	ATF6	9	10	19	1121.811
#260	SOX11	9	13	22	1193.331
#261	MAFF	9	9	18	622.409
#262	EPAS1	9	11	20	698.688
#263	PAX6	9	11	20	1381.362
#264	HOXC8	9	14	23	1597.784
#265	ARNT2	9	12	21	1020.76
#266	RUNX1	9	10	19	6393.709
#267	ATF3	9	6	15	1091.499
#268	ZNF277	9	8	17	969.513
#269	NR4A3	9	9	18	892.854
#270	HSF1	9	11	20	757.859
#271	MEOX1	9	9	18	737.063
#272	EHF	9	11	20	1322.366
#273	KLF12	9	12	21	1052.947
#274	TRIM25	9	5	14	488.65
#275	ZIC1	9	7	16	952.074
#276	RUNX2	9	14	23	1166.968
#277	PHOX2A	9	10	19	1169.509
#278	FOXO3	9	10	19	905.966
#279	ZIC3	9	9	18	672.9
#280	IRX5	9	12	21	1513.657
#281	SLC2A4RG	9	12	21	881.269
#282	SOX2	9	12	21	1487.976
#283	OVOL1	9	17	26	1099.818
#284	TFE3	9	9	18	1219.297
#285	MLLT10	9	8	17	1116.707
#286	ATF6B	9	8	17	646.901
#287	HSF4	9	10	19	702.026
#288	ELF1	9	7	16	1077.631
#289	IKZF3	9	12	21	1285.131
#290	OLIG2	9	11	20	1706.028
#291	PTH	9	13	22	1294.654
#292	HOXD11	9	9	18	1352.969
#293	FOXC1	9	11	20	1397.6
#294	MLXIPL	9	15	24	1001.039
#295	HOXD9	8	7	15	633.931
#296	SIM1	8	9	17	1381.524
#297	NR1H4	8	13	21	1066.057
#298	EMX1	8	11	19	879.792
#299	TBX19	8	11	19	1233.792
#300	MSX1	8	12	20	2142.337
#301	THRA	8	11	19	1819.205
#302	PHOX2B	8	9	17	969.183
#303	TBX1	8	10	18	1458.33
#304	REST	8	12	20	1949.446
#305	CRX	8	14	22	975.255
#306	MYF6	8	8	16	1031.907
#307	SNAPC5	8	15	23	1553.097
#308	HLF	8	8	16	562.969
#309	HOXB3	8	13	21	1195.353
#310	PRDM2	8	9	17	617.951
#311	NFYA	8	17	25	1146.73
#312	ESR1	8	12	20	999.468
#313	ZFP36L1	8	17	25	2130.303
#314	HESX1	8	10	18	988.416
#315	CITED1	8	12	20	1680.434
#316	TBX3	8	8	16	720.755
#317	TCF15	8	11	19	870.033
#318	WNT5A	8	11	19	795.694
#319	HMX1	8	8	16	915.771
#320	HOXB1	8	10	18	1203.252
#321	TFDP2	8	12	20	1915.856
#322	IRX4	8	7	15	1007.674
#323	PITX2	8	10	18	539.92
#324	MBD1	8	14	22	1643.402
#325	FOXO1	8	8	16	780.292
#326	FOXI1	8	9	17	2069.511
#327	TFEB	8	11	19	995.286
#328	TEAD1	8	10	18	1072.868
#329	CBL	8	12	20	643.656
#330	SOX5	8	5	13	711.499
#331	SP140	8	8	16	478.167
#332	ESRRB	8	8	16	945.019
#333	E2F6	8	12	20	1265.786
#334	ZNF41	8	8	16	713.789
#335	PGR	8	12	20	1438.886
#336	HMGA1	7	17	24	1635.456
#337	HIF3A	7	12	19	1154.998
#338	ALX4	7	10	17	949.309
#339	SOX30	7	13	20	773.409
#340	PPBPL2	7	11	18	674.324
#341	E2F2	7	12	19	635.317
#342	ASCL1	7	15	22	1022.357
#343	ONECUT1	7	13	20	596.015
#344	MYCL1	7	10	17	1057.374
#345	GATA3	7	13	20	1123.279
#346	BACH1	7	11	18	799.322
#347	FOXD3	7	11	18	1301.588
#348	ECSIT	7	7	14	358.969
#349	RB1	7	11	18	1186.469
#350	ELK4	7	11	18	1306.634
#351	POU3F2	7	16	23	939.078
#352	TBX2	7	12	19	1329.418
#353	JUND	7	10	17	568.411
#354	LHX6	7	12	19	1541.555
#355	ZNF3	7	11	18	875.916
#356	NKX2-8	7	9	16	363.995
#357	HOXA11	7	13	20	972.529
#358	HOXC10	7	7	14	505.805
#359	ELF5	7	12	19	677.22
#360	CEBPD	7	13	20	994.605
#361	POU2F3	7	18	25	1540.927
#362	TBX6	7	13	20	889.028
#363	MEOX2	7	11	18	457.064
#364	NKX2-1	7	12	19	1506.257
#365	FOXE1	7	15	22	1458.995
#366	STAT1	7	9	16	613.248
#367	SOX17	7	8	15	305.08
#368	MYC	7	15	22	721.161
#369	TAF1B	7	6	13	453.319
#370	SCML1	7	13	20	1209.624
#371	IKZF1	7	8	15	1065.546
#372	NEUROG1	7	12	19	1102.163
#373	MYF5	7	14	21	1197.475
#374	NR2F1	7	10	17	901.632
#375	NR2C1	6	12	18	469.274
#376	TP63	6	10	16	821.713
#377	PCGF2	6	14	20	808.139
#378	ERG	6	10	16	755.885
#379	TADA2A	6	9	15	739.974
#380	TLX3	6	12	18	1724.527
#381	GRHL2	6	13	19	914.554
#382	HMG20B	6	8	14	532.235
#383	RXRG	6	11	17	617.429
#384	PKNOX1	6	15	21	1081.747
#385	ATF5	6	6	12	462.142
#386	ZNF81	6	11	17	651.644
#387	RERE	6	17	23	1188.977
#388	TBX5	6	13	19	1841.127
#389	PAX8	6	12	18	585.137
#390	CTBP1	6	13	19	589.941
#391	ZNF135	6	9	15	246.02
#392	NEUROD1	6	12	18	1208.497
#393	SIX1	6	7	13	483.627
#394	CREBBP	6	11	17	385.807
#395	HEY2	6	10	16	550.664
#396	HOXC13	6	9	15	709.36
#397	ZNF174	6	16	22	904.1
#398	ZNF83	6	8	14	707.83
#399	SUPT4H1	6	6	12	559.142
#400	ZNF154	6	11	17	689.341
#401	TP53	6	12	18	732.842
#402	SPI1	6	16	22	689.667
#403	DLX2	6	13	19	1046.894
#404	CLOCK	6	13	19	1329.572
#405	NR5A2	6	15	21	1128.461
#406	GCM1	6	11	17	1028.797
#407	FOSB	6	10	16	591.27
#408	VTN	6	7	13	503.262
#409	PAX4	6	9	15	1368.262
#410	NPAT	6	10	16	712.482
#411	LHX1	6	11	17	1266.454
#412	CSRNP3	6	12	18	738.809
#413	SNAPC4	6	9	15	748.204
#414	MEF2D	6	14	20	1083.809
#415	SPIB	6	14	20	1073.644
#416	TSC22D3	5	13	18	654.306
#417	TSHZ2	5	14	19	1160.23
#418	ZNF93	5	17	22	1111.321
#419	ZNF202	5	13	18	526.565
#420	FOSL1	5	15	20	782.204
#421	SMAD1	5	7	12	415.5
#422	MEIS3P1	5	13	18	1234.561
#423	SMAD9	5	12	17	645.417
#424	IRF5	5	12	17	1298.002
#425	RFXAP	5	8	13	446.898
#426	POU1F1	5	11	16	581.027
#427	POU6F1	5	18	23	926.471
#428	SCRT1	5	16	21	660.399
#429	ZBTB48	5	13	18	631.221
#430	TAF13	5	11	16	977.86
#431	LHX2	5	9	14	723.894
#432	CREB5	5	14	19	663.486
#433	BARX1	5	13	18	1231.787
#434	SHOX	5	15	20	878.356
#435	ZNF215	5	14	19	1245.076
#436	HOXB13	5	12	17	605.886
#437	RARA	5	15	20	1395.924
#438	TEF	5	15	20	1059.949
#439	CREBZF	5	9	14	359.187
#440	FOXA1	5	11	16	1045.38
#441	FOXD1	5	18	23	918.185
#442	EN2	5	15	20	860.622
#443	TLX2	5	15	20	1393.076
#444	POU4F3	5	14	19	949.653
#445	CUX2	5	15	20	2460.089
#446	PAX3	5	14	19	1325.579
#447	NRL	5	10	15	628.125
#448	DMRT1	5	12	17	1146.688
#449	SIX3	5	11	16	802.914
#450	CDKN2A	4	10	14	331.566
#451	SMAD6	4	16	20	948.006
#452	FOXG1	4	15	19	650.288
#453	HOXA1	4	15	19	525.831
#454	MYT1L	4	12	16	510.861
#455	RCAN1	4	15	19	1045.411
#456	FOXC2	4	12	16	781.775
#457	ZNF639	4	13	17	505.247
#458	HOXC5	4	10	14	456.418
#459	FOXJ1	4	14	18	1039.831
#460	IRF4	4	11	15	650.056
#461	ALX3	4	12	16	1061.103
#462	ST18	4	18	22	711.365
#463	HIRA	4	14	18	528.799
#464	HCFC1	4	14	18	527.874
#465	HOXD1	4	10	14	433.513
#466	ZNF134	4	14	18	1424.131
#467	NR5A1	4	12	16	583.037
#468	NFKB2	4	16	20	954.935
#469	TADA3	4	10	14	250.513
#470	GLI2	4	10	14	509.818
#471	LEF1	4	11	15	487.855
#472	YY1	4	11	15	407.274
#473	WT1	4	14	18	521.566
#474	GATA1	4	11	15	709.161
#475	FOXB1	4	9	13	1012.886
#476	TRIM29	3	18	21	816.954
#477	SRY	3	13	16	731.091
#478	POU3F1	3	11	14	359.643
#479	TFAP2C	3	14	17	397.049
#480	GATA4	3	12	15	506.557
#481	PHF1	3	14	17	376.473
#482	POU2F2	3	7	10	274.551
#483	ZNF157	3	13	16	273.281
#484	ETV2	3	13	16	568.059
#485	POU3F3	3	12	15	491.103
#486	ZNF155	3	16	19	740.032
#487	MXD1	3	8	11	285.04
#488	EGR4	2	20	22	581.241
#489	PLAG1	2	9	11	304.906
#490	RARG	2	14	16	415.771
#491	BATF	2	12	14	123.052
#492	GSC2	2	15	17	324.471
#493	HNF4A	2	12	14	272.217
#494	KDM5B	2	9	11	311.863
#495	ZNF167	2	15	17	864.478
#496	NR4A1	1	10	11	67.843
#497	TFAP2B	1	14	15	79.806
#498	SMAD3	1	10	11	114.37
#499	HOXD3	1	13	14	177.254
#500	HOXD13	0	12	12	0