Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	SPEN	58	6	64	972.54
#2	ZNF81	50	3	53	1688.869
#3	STAT3	47	7	54	1441.413
#4	ZNF3	42	4	46	717.104
#5	SUPT4H1	41	6	47	3938.072
#6	TADA2A	41	4	45	242.607
#7	KDM5A	40	10	50	573.234
#8	POU4F1	40	4	44	756.996
#9	POU5F1B	39	11	50	1063.695
#10	TP53	38	8	46	2177.05
#11	PRDM1	37	7	44	892.396
#12	ZNF75D	37	5	42	213.103
#13	CUX1	36	6	42	586.338
#14	ST18	36	7	43	429.59
#15	SUPT6H	35	5	40	149.118
#16	GABPA	34	12	46	719.721
#17	MYBL2	33	8	41	778.904
#18	MZF1	33	5	38	538.421
#19	GTF2H3	32	9	41	895.512
#20	FOXO1	32	5	37	716.291
#21	ECSIT	32	10	42	2854.557
#22	ZNF483	32	6	38	1473.151
#23	RELA	32	7	39	1433.305
#24	ZNF445	32	5	37	440.572
#25	HEY2	30	8	38	682.142
#26	TFCP2	30	11	41	946.003
#27	NFE2L2	30	11	41	877.93
#28	NOTCH1	29	6	35	1031.571
#29	NR2F6	29	7	36	284.698
#30	POU2F2	29	6	35	170.161
#31	CREB3L3	28	7	35	1213.123
#32	IKZF1	28	7	35	491.446
#33	NPAS2	28	10	38	1485.043
#34	MTA3	28	10	38	2892.442
#35	TBX3	28	13	41	783.333
#36	ZFP90	27	15	42	1184.351
#37	HIF1A	27	8	35	982.025
#38	ZSCAN23	27	14	41	2273.29
#39	CBL	27	8	35	1003.141
#40	IRF6	27	11	38	1233.326
#41	BHLHE41	26	7	33	444.395
#42	CREB1	26	12	38	947.336
#43	SIX5	26	12	38	843.694
#44	RARA	26	11	37	3063.62
#45	KLF16	25	16	41	2077.936
#46	STAT1	25	11	36	1228.746
#47	TCF3	25	9	34	772.227
#48	NFATC2	25	6	31	767.911
#49	MAFG	24	9	33	852.87
#50	ARNTL	24	11	35	2045.549
#51	SNAPC5	23	13	36	1469.146
#52	IRF8	23	1	24	133.952
#53	GTF2H2	23	5	28	1223.321
#54	ZXDC	23	14	37	1559.352
#55	PHF1	23	12	35	4094.568
#56	ZNF193	23	10	33	650.313
#57	TSC22D2	23	6	29	622.906
#58	MTF1	23	17	40	1334.11
#59	ARNT2	23	12	35	1717.652
#60	T	23	11	34	2252.64
#61	ZNF207	22	8	30	1832.741
#62	SMAD5	22	10	32	408.417
#63	ISL1	22	8	30	604.381
#64	MMP14	22	14	36	2388.406
#65	RUNX1	22	8	30	739.411
#66	MSX2	22	12	34	1228.858
#67	CBFA2T2	22	6	28	402.319
#68	MAX	21	9	30	1244.792
#69	ZNF18	21	17	38	1025.772
#70	EGR2	21	8	29	2673.872
#71	RERE	21	12	33	888.185
#72	ARID4A	21	15	36	1078.132
#73	SPIC	21	6	27	833.008
#74	FOXP1	21	10	31	1674.55
#75	TCF21	21	11	32	2275.768
#76	PKNOX1	21	12	33	1422.794
#77	PURB	21	8	29	826.26
#78	TLX3	21	12	33	2007.272
#79	NFYC	20	7	27	499.655
#80	SOX1	20	15	35	1208.227
#81	ZNF498	20	13	33	523.932
#82	TAF12	20	6	26	265.816
#83	AFF4	20	13	33	1981.501
#84	ZNF367	20	9	29	487.258
#85	CREM	19	13	32	809.537
#86	ATF5	19	8	27	417.931
#87	ZBTB38	19	13	32	1015.314
#88	TFAP2A	19	11	30	2113.559
#89	NFATC3	19	15	34	1386.666
#90	TFE3	19	10	29	1426.778
#91	TBX2	19	10	29	1709.098
#92	HMG20B	19	12	31	2481.212
#93	NPAT	18	10	28	634.582
#94	SPIB	18	12	30	829.717
#95	HSF1	18	15	33	690.182
#96	FOXP2	18	10	28	868.07
#97	MYT1	18	10	28	1190.344
#98	HES6	18	11	29	1399.735
#99	NR2E3	18	13	31	1495.966
#100	SREBF1	18	10	28	786.245
#101	ZFHX4	17	14	31	1702.278
#102	WT1	17	13	30	745.215
#103	LEF1	17	10	27	973.319
#104	NEUROD1	17	9	26	2085.682
#105	ELF1	17	10	27	1031.286
#106	MSRB2	17	12	29	1519.143
#107	ZNF93	17	17	34	1010.273
#108	ZNF45	17	10	27	908.916
#109	ZNF256	17	13	30	1114.822
#110	ARX	17	12	29	1395.894
#111	ZGPAT	17	16	33	2858.545
#112	C1orf85	16	17	33	1144.595
#113	RARB	16	11	27	1354.602
#114	CEBPD	16	13	29	2569.8
#115	ESRRG	16	13	29	917.908
#116	NR4A1	16	11	27	736.642
#117	ZIC2	16	13	29	356.77
#118	HHEX	16	15	31	2491.461
#119	NFYA	16	17	33	837.322
#120	HMGA1	16	13	29	446.97
#121	TFEB	16	12	28	769.025
#122	CREB3L2	16	7	23	769.083
#123	ETS2	16	8	24	1538.876
#124	BUD31	16	10	26	599.506
#125	ETV6	15	12	27	696.67
#126	TBX19	15	10	25	601.736
#127	KCNH8	15	11	26	1782.352
#128	ELF4	15	11	26	585.417
#129	GATA2	15	14	29	1131.922
#130	CREBBP	15	15	30	2832.673
#131	MTA2	15	11	26	2235.13
#132	BHLHE40	15	13	28	1996.95
#133	TRPS1	15	16	31	3296.333
#134	RORA	15	14	29	2800.121
#135	PPARD	15	14	29	462.546
#136	ZSCAN20	15	12	27	1644.826
#137	ZSCAN1	15	13	28	1240.716
#138	PLAG1	15	7	22	486.915
#139	PAX4	15	12	27	1473.869
#140	GATAD1	15	7	22	2288.769
#141	NFIC	15	8	23	585.714
#142	MAFB	14	9	23	787.741
#143	SOX4	14	5	19	529.684
#144	TGIF1	14	10	24	1197.248
#145	NFE2	14	11	25	2141.637
#146	ZNF287	14	9	23	713.599
#147	EGR4	14	7	21	145.021
#148	MYT1L	14	13	27	1157.234
#149	CDKN2A	14	15	29	2204.39
#150	PPARA	14	12	26	2362.855
#151	GATA6	14	15	29	1863.134
#152	MESP1	14	11	25	369.935
#153	ZFPM2	14	9	23	1513.047
#154	ZNF238	14	8	22	1311.045
#155	E2F3	14	18	32	1336.881
#156	ERF	14	9	23	2488.708
#157	ZNF165	14	12	26	1953.428
#158	MITF	14	9	23	999.951
#159	HOXA5	14	12	26	1803.958
#160	C2orf3	14	10	24	1003.903
#161	NR2F2	14	12	26	447.684
#162	HOXD10	14	17	31	2216.555
#163	HOXD4	14	6	20	870.955
#164	NFIX	13	11	24	1720.074
#165	ZNF157	13	16	29	966.847
#166	ASCL2	13	12	25	1612.494
#167	ZNF117	13	13	26	963.4
#168	HMGA2	13	12	25	1821.178
#169	FOSB	13	10	23	1551.486
#170	NEUROD2	13	9	22	1596.686
#171	FOXA1	13	12	25	1716.54
#172	DLX3	13	12	25	1696.277
#173	ZNF197	13	17	30	1337.705
#174	ZBTB17	13	11	24	1745.298
#175	ZFHX3	13	11	24	1727.767
#176	VSX1	13	11	24	1211.212
#177	HOXB2	13	12	25	1787.096
#178	NCOR1	13	15	28	1890.11
#179	IRF4	13	11	24	535.444
#180	ZNF500	13	12	25	2373.68
#181	ATF6	13	16	29	693.62
#182	EBF1	12	10	22	945.603
#183	PKNOX2	12	12	24	1394.274
#184	ELF5	12	13	25	3149.323
#185	ATF6B	12	12	24	736.923
#186	PCGF2	12	14	26	875.091
#187	MAF	12	11	23	751.967
#188	MKX	12	15	27	1530.582
#189	KLF9	12	12	24	1404.339
#190	NR1H4	12	10	22	1092.329
#191	TP63	12	18	30	2570.318
#192	ZEB2	12	10	22	807.509
#193	MYCN	12	13	25	1138.64
#194	ESR2	12	14	26	968.809
#195	POU2F3	12	16	28	1532.323
#196	PRRX1	12	12	24	953.692
#197	NFATC4	12	15	27	2187.172
#198	FOXL1	12	14	26	1564.372
#199	FOXD1	12	11	23	475.59
#200	UHRF1	12	9	21	1303.999
#201	SOX21	12	15	27	630.303
#202	IRX1	12	10	22	910.102
#203	HIRA	12	14	26	1629.527
#204	SCRT1	12	16	28	1841.267
#205	ISL2	12	16	28	1214.198
#206	TFDP1	12	13	25	1204.473
#207	AHR	12	10	22	875.763
#208	SNAPC4	12	13	25	1772.364
#209	RXRB	12	13	25	2041.571
#210	NFAT5	12	12	24	1429.759
#211	TFDP2	12	11	23	1807.714
#212	FOXH1	12	11	23	832.268
#213	ZIC1	12	18	30	1378.567
#214	BNC1	12	16	28	2254.728
#215	HCFC1	11	10	21	449.115
#216	BCL6	11	9	20	609.604
#217	DMRT2	11	12	23	514.973
#218	NR5A2	11	12	23	2816.852
#219	GTF2H4	11	14	25	2339.886
#220	CREBZF	11	14	25	1087.107
#221	ZNF154	11	11	22	812.657
#222	DMBX1	11	16	27	1139.093
#223	TSC22D3	11	11	22	620.936
#224	POU6F1	11	12	23	300.035
#225	TCF20	11	14	25	1191.94
#226	HOXA7	11	11	22	1256.099
#227	TRIM29	11	15	26	2244.581
#228	MEIS3	11	13	24	731.332
#229	HOXD13	11	17	28	1241.461
#230	AHCTF1	11	13	24	1220.777
#231	GATAD2B	11	14	25	1353.718
#232	SP140	11	12	23	1722.392
#233	TULP4	11	9	20	1455.59
#234	STRN3	11	14	25	2051.321
#235	EGR3	11	16	27	1511.593
#236	NFIA	11	15	26	1452.984
#237	JUN	11	17	28	1660.439
#238	GATA3	11	12	23	619.949
#239	GLIS3	11	9	20	1026.74
#240	RAX	11	11	22	555.359
#241	DLX4	11	10	21	766.379
#242	MEIS2	11	14	25	3108.877
#243	TBX5	11	17	28	1153.998
#244	EPAS1	11	15	26	1064.066
#245	GLI3	10	12	22	503.639
#246	FOSL1	10	14	24	1465.92
#247	CSRNP3	10	11	21	1353.106
#248	LHX9	10	15	25	1451.955
#249	MECOM	10	12	22	1331.36
#250	ZSCAN2	10	13	23	1411.859
#251	SOX6	10	15	25	896.28
#252	FOXQ1	10	14	24	864.855
#253	MYC	10	14	24	1304.768
#254	ZNF41	10	14	24	1078.433
#255	SMAD9	10	19	29	1953.54
#256	ZBTB48	10	10	20	321.87
#257	ZNF169	10	16	26	1195.431
#258	MLL	10	16	26	1180.042
#259	KLF15	10	10	20	544.914
#260	CTBP1	10	16	26	1891.206
#261	PBX4	10	12	22	1753.31
#262	HOXD9	10	13	23	1080.102
#263	SLC26A3	10	9	19	1247.051
#264	SOX5	10	12	22	1186.418
#265	ZNF71	10	16	26	2925.332
#266	SIX1	10	11	21	651.093
#267	NR1H3	10	8	18	469.356
#268	FOXK2	10	12	22	1629.899
#269	TSHZ2	9	10	19	814.589
#270	POU3F2	9	14	23	908.143
#271	SOX2	9	17	26	965.246
#272	SPI1	9	13	22	978.302
#273	ZIC3	9	12	21	1802.261
#274	NANOGNB	9	12	21	1287.287
#275	RORC	9	12	21	657.97
#276	MAFF	9	14	23	877.121
#277	POU3F1	9	16	25	1391.703
#278	HNF4G	9	10	19	1413.763
#279	ZFP36L2	9	12	21	1429.499
#280	TCF7L2	9	7	16	333.24
#281	PPARG	9	3	12	107.661
#282	RCOR1	9	14	23	1177.145
#283	MLLT10	9	14	23	436.356
#284	SOX15	9	14	23	1131.569
#285	NR4A3	9	17	26	1307.828
#286	HOXA9	9	12	21	1000.452
#287	CSDA	9	18	27	1537.508
#288	NFYB	9	11	20	705.673
#289	CRX	9	13	22	1182.548
#290	KLF2	9	15	24	1390.562
#291	PAX6	9	10	19	895.844
#292	MNT	9	10	19	633.22
#293	PAX8	9	12	21	1356.984
#294	REL	9	17	26	1086.39
#295	ATF7	9	14	23	1334.482
#296	SMAD1	8	10	18	772.405
#297	SCAND1	8	13	21	687.977
#298	ZNF202	8	11	19	344.339
#299	RFX3	8	16	24	1246.738
#300	LMX1A	8	13	21	1291.294
#301	ETV7	8	7	15	730.629
#302	ZNF215	8	17	25	1140.164
#303	TWIST1	8	12	20	1250.238
#304	GAS7	8	12	20	1058.802
#305	MYNN	8	17	25	1268.34
#306	TEAD2	8	15	23	1153.649
#307	NPAS1	8	18	26	622.779
#308	FOXO3	8	9	17	662.419
#309	PITX1	8	11	19	582.692
#310	HLF	8	14	22	1009.015
#311	ZNF19	8	14	22	831.946
#312	ZNF396	8	12	20	921.805
#313	POU2F1	8	14	22	1121.214
#314	ATOH1	8	11	19	704.35
#315	NR2F1	8	10	18	790.317
#316	FEV	8	12	20	1416.258
#317	TRERF1	8	17	25	1132.354
#318	TAL1	8	17	25	1903.191
#319	PRDM2	8	14	22	1448.641
#320	MLXIPL	8	19	27	1560.87
#321	MYF5	8	13	21	525.192
#322	HOXB7	8	10	18	860.674
#323	FOXO4	8	13	21	390.353
#324	LZTS1	8	12	20	933.394
#325	HOXD1	8	12	20	482.801
#326	HIF3A	8	16	24	967.04
#327	FOXE1	8	9	17	754.356
#328	ZNF277	8	13	21	1551.077
#329	BATF2	8	18	26	986.929
#330	GCM1	8	14	22	806.506
#331	PEG3	8	10	18	766.108
#332	PBX1	7	13	20	721.812
#333	HOPX	7	13	20	1723.563
#334	TADA3	7	14	21	821.793
#335	EGR1	7	11	18	624.219
#336	NR4A2	7	13	20	797.154
#337	TSC22D1	7	13	20	1029
#338	ZFP42	7	15	22	1861.98
#339	ZSCAN10	7	12	19	703.92
#340	PBX3	7	9	16	357.877
#341	ZNF192	7	11	18	895.738
#342	SOX7	7	8	15	263.418
#343	ETV4	7	16	23	888.762
#344	ZNF131	7	15	22	646.882
#345	LMX1B	7	18	25	947.321
#346	RAX2	7	15	22	259.395
#347	IRF5	7	10	17	749.143
#348	RCOR2	7	12	19	1295.462
#349	DLX1	7	11	18	476.237
#350	STAT5B	7	13	20	691.25
#351	POU1F1	7	13	20	1204.888
#352	ZNF397	7	13	20	827.226
#353	SMAD4	7	17	24	975.004
#354	PGBD1	7	13	20	891.815
#355	SOX30	7	13	20	510.352
#356	HOXA2	7	12	19	982.004
#357	SP1	7	13	20	1519.982
#358	HOXA10	7	16	23	930.726
#359	ALX3	7	14	21	1169.091
#360	SMAD6	7	13	20	1166.713
#361	HNF4A	7	8	15	786.694
#362	KLF4	7	16	23	1443.387
#363	TSHZ3	7	14	21	881.43
#364	ZNF449	7	17	24	1544.04
#365	FOXK1	7	10	17	748.035
#366	GLI2	7	14	21	859.118
#367	TP73	7	15	22	1191.95
#368	BLZF1	7	12	19	353.653
#369	MEOX2	7	12	19	2677.182
#370	OTX2	7	16	23	725.068
#371	ZIC5	7	8	15	606.745
#372	NRL	6	11	17	844.924
#373	ESR1	6	15	21	1393.505
#374	SCAND2	6	14	20	1055.39
#375	NKX2-8	6	8	14	307.37
#376	NFATC1	6	13	19	691.973
#377	FOXD3	6	15	21	1169.637
#378	ZNF639	6	14	20	1133.719
#379	LHX8	6	17	23	2023.767
#380	KLF6	6	13	19	762.057
#381	NR6A1	6	14	20	703.802
#382	ZNF496	6	18	24	2733.188
#383	DLX6	6	16	22	512.804
#384	NFKB2	6	12	18	268.318
#385	IKZF4	6	13	19	286.596
#386	THRA	6	19	25	1341.891
#387	PHTF1	6	17	23	1439.396
#388	RORB	6	18	24	971.589
#389	ZNF219	6	9	15	445.742
#390	ZNF83	6	16	22	892.717
#391	EVX1	6	12	18	1072.47
#392	WNT5A	6	17	23	1262.956
#393	SIX3	6	13	19	847.035
#394	HSF5	6	11	17	579.96
#395	SIX2	6	20	26	1163.029
#396	ARNT	6	10	16	766.706
#397	OLIG2	6	16	22	708.875
#398	TBX1	6	12	18	2742.157
#399	PROX1	6	17	23	879.237
#400	L3MBTL4	6	16	22	1259.592
#401	TCF7L1	6	13	19	950.362
#402	BCL3	6	16	22	403.855
#403	NR3C2	6	16	22	484.235
#404	SCML1	6	18	24	716.252
#405	NANOG	6	10	16	673.15
#406	CNOT7	6	15	21	1461.064
#407	ESX1	5	15	20	602.471
#408	MEF2D	5	14	19	907.338
#409	NKX6-2	5	17	22	855.933
#410	PTH	5	18	23	2161.989
#411	ZFP36L1	5	13	18	939.089
#412	CUX2	5	13	18	1113.816
#413	ANKRD30A	5	16	21	781.341
#414	ELK4	5	10	15	312.836
#415	KLF12	5	13	18	586.115
#416	FOXL2	5	17	22	1804.369
#417	TEAD1	5	13	18	642.282
#418	HMGB2	5	17	22	843.48
#419	SOX18	5	16	21	1257.322
#420	PHOX2B	5	16	21	855.88
#421	RUNX2	5	15	20	686.041
#422	HNRNPAB	5	18	23	787.979
#423	NKX3-2	5	17	22	1608.583
#424	TEF	5	20	25	1410.839
#425	TLX2	5	13	18	1667.827
#426	GSX1	5	15	20	562.251
#427	SOX9	5	9	14	330.204
#428	SEBOX	5	13	18	315.733
#429	ZHX2	5	12	17	614.9
#430	ZNF236	5	12	17	759.506
#431	HESX1	5	14	19	634.224
#432	FOXS1	5	10	15	761.392
#433	LHX1	5	19	24	846.681
#434	KLF17	5	12	17	933.187
#435	SIM1	5	21	26	905.361
#436	ELF3	5	10	15	317.652
#437	TFAP2C	5	14	19	883.266
#438	PITX2	5	17	22	757.509
#439	FOXN3	5	11	16	492.915
#440	SIN3A	5	12	17	376.476
#441	ETS1	5	15	20	506.868
#442	HOXA13	5	10	15	339.54
#443	FOXC2	4	13	17	417.21
#444	CREB5	4	15	19	336.354
#445	ZNF80	4	14	18	728.018
#446	SOX11	4	14	18	873.66
#447	ASCL1	4	15	19	219.594
#448	STAT2	4	13	17	191.129
#449	E2F2	4	12	16	443.233
#450	RXRG	4	12	16	673.771
#451	ZNF148	4	19	23	618.428
#452	PLSCR1	4	12	16	450.128
#453	IRX3	4	11	15	264.259
#454	PAX3	4	13	17	654.923
#455	ETV5	4	18	22	1641.034
#456	LASS6	4	14	18	530.669
#457	FLI1	4	16	20	564.749
#458	SIX4	4	14	18	521.949
#459	EHF	4	12	16	703.753
#460	YY1	4	15	19	420.676
#461	HOXD3	4	19	23	867.32
#462	ETV1	4	15	19	678.118
#463	TFAP4	4	13	17	439.373
#464	ERG	4	15	19	577.692
#465	PGR	4	17	21	409.631
#466	ZNF24	4	17	21	497.138
#467	ZNF438	4	14	18	469.742
#468	NFIB	4	12	16	1179.368
#469	C11orf9	4	14	18	520.737
#470	FOXI1	4	13	17	660.094
#471	RUNX1T1	4	15	19	735.17
#472	GATA4	4	7	11	69.222
#473	TCF12	4	17	21	531.563
#474	MGA	4	13	17	1436.463
#475	MSX1	4	11	15	499.262
#476	FOXC1	3	11	14	209.683
#477	RCAN1	3	8	11	202.497
#478	HOXB1	3	14	17	351.166
#479	BCL11B	3	11	14	241.117
#480	ATF2	3	15	18	410.004
#481	ZSCAN4	3	16	19	913.629
#482	FOXB1	3	10	13	428.57
#483	AR	3	11	14	324.361
#484	SALL1	3	17	20	637.71
#485	ZNF92	3	18	21	287.276
#486	TAF1B	3	11	14	427.459
#487	TBX22	3	11	14	349.169
#488	ARNTL2	3	11	14	465.429
#489	THRB	3	18	21	346.909
#490	TFEC	3	17	20	343.579
#491	FOXA3	3	9	12	288.605
#492	FOSL2	2	16	18	368.106
#493	ALS2CR8	2	8	10	81.595
#494	IRX4	2	17	19	559.945
#495	TBX20	2	16	18	640.159
#496	ZNF167	2	18	20	169.299
#497	HOXD11	2	12	14	401.226
#498	ZNF434	2	13	15	187.531
#499	HOXB9	1	17	18	250.815
#500	TFAP2B	1	11	12	104.741