Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	FOXE1	79	4	83	3329.328
#2	HHEX	76	5	81	1574.666
#3	IRX5	73	3	76	943.608
#4	HOPX	60	7	67	1105.339
#5	SPDEF	59	5	64	1028.343
#6	ETS2	56	10	66	926.99
#7	FOXF1	56	5	61	140.401
#8	KLF5	55	4	59	116.589
#9	ENO1	55	6	61	2553.24
#10	TFAP2A	55	5	60	2650.315
#11	BHLHE41	55	10	65	5955.241
#12	ZFHX3	54	13	67	8257.09
#13	HMGA1	53	8	61	2035.771
#14	CITED2	52	13	65	853.369
#15	TRPS1	51	5	56	91.877
#16	FOXA1	51	4	55	166.856
#17	AFF1	50	6	56	834.173
#18	EPAS1	49	6	55	249.527
#19	NFYC	49	5	54	2521.592
#20	GATAD1	48	5	53	109.961
#21	NKX2-1	48	4	52	339.447
#22	RUNX1	47	11	58	630.377
#23	PAX8	46	2	48	63.38
#24	RFXANK	46	5	51	1661.117
#25	TBX3	46	11	57	3179.48
#26	DRAP1	45	8	53	800.565
#27	GATA3	45	3	48	47.237
#28	ELF3	45	5	50	263.026
#29	MEF2C	43	8	51	470.371
#30	NR1I2	43	5	48	631.74
#31	FOXM1	43	5	48	2199.984
#32	RXRB	41	5	46	1134.7
#33	SOX4	40	11	51	1220.5
#34	XBP1	40	3	43	71.852
#35	NR3C1	40	11	51	949.057
#36	FOXA2	40	6	46	1602.292
#37	E2F6	40	11	51	1935.571
#38	REL	39	12	51	8663.989
#39	MZF1	37	8	45	276.605
#40	MAX	37	7	44	478.562
#41	KLF9	36	8	44	250.952
#42	ZNF446	35	12	47	679.048
#43	GTF2I	35	8	43	2588.956
#44	TRIM28	35	8	43	1710.156
#45	HOXC10	35	9	44	296.926
#46	TADA3	34	14	48	2592.935
#47	SUPT6H	34	9	43	1811.83
#48	ALS2CR8	34	9	43	5843.147
#49	HMG20B	34	12	46	8831.989
#50	MEIS3P1	33	12	45	1263.606
#51	NR3C2	33	5	38	309.302
#52	HLF	33	8	41	666.672
#53	TCF25	32	12	44	2968.61
#54	ZSCAN18	32	14	46	2076.75
#55	MAFB	31	13	44	1262.33
#56	LASS2	31	17	48	3137.49
#57	PURA	31	17	48	4255.33
#58	TCF21	31	10	41	1112.243
#59	NPAT	30	16	46	8089.196
#60	SALL1	30	8	38	6811.278
#61	SATB1	30	8	38	392.195
#62	CDX2	30	9	39	2650.843
#63	FOSL2	29	11	40	1772.056
#64	AR	29	9	38	409.325
#65	HSF1	29	9	38	7019.654
#66	STAT3	29	17	46	3538.92
#67	AEBP1	29	11	40	946.882
#68	ESR1	29	8	37	551.778
#69	FLI1	29	10	39	1377.635
#70	YBX1	29	9	38	970.722
#71	JUND	29	11	40	1321.078
#72	TCFL5	28	13	41	3026.135
#73	VTN	28	11	39	636.244
#74	MEIS1	28	10	38	613.049
#75	TP63	28	4	32	423.232
#76	EHF	28	15	43	1787.697
#77	C11orf9	28	12	40	476.33
#78	SMAD3	28	12	40	413.539
#79	CREB3L1	27	10	37	797.595
#80	NR1I3	27	8	35	8013.639
#81	NFIC	27	9	36	1021.405
#82	ARNTL2	27	7	34	337.137
#83	MAF	27	13	40	306.197
#84	ZFP36L2	26	9	35	899.638
#85	PBX1	26	16	42	1705.275
#86	MECOM	25	13	38	2885.019
#87	BNC1	25	9	34	2434.188
#88	NR1H4	25	9	34	525.899
#89	BHLHE40	25	20	45	1085.57
#90	MEOX2	25	11	36	1876.266
#91	BCL3	25	9	34	439.159
#92	BATF	25	10	35	145.999
#93	TCF4	25	15	40	2875.314
#94	TRIM29	25	9	34	847.253
#95	GLI3	25	13	38	432.142
#96	HOXC4	24	10	34	121.013
#97	ZGPAT	24	14	38	3285.823
#98	PITX1	24	12	36	2141.158
#99	SOX10	24	16	40	1863.711
#100	CSDA	24	16	40	3225.641
#101	MGA	24	14	38	1055.477
#102	PCGF2	24	15	39	7083.669
#103	ETV1	23	13	36	542.191
#104	ZHX2	23	17	40	4437.032
#105	SNAI2	23	12	35	1842.567
#106	ZNF91	23	14	37	699.503
#107	PHOX2B	23	12	35	786.66
#108	HOXA1	23	13	36	1053.595
#109	GTF2H4	23	14	37	2996.526
#110	IRF8	22	11	33	956.996
#111	FOSL1	22	14	36	535.646
#112	ZNF45	22	16	38	1065.884
#113	SNAPC4	22	13	35	2144.8
#114	SCML1	21	9	30	2618.265
#115	SPEN	21	7	28	547.353
#116	SPIB	21	21	42	4976.851
#117	ZBTB48	21	10	31	515.993
#118	POU6F1	21	15	36	682.593
#119	HNF1B	20	8	28	897.057
#120	BCL11B	20	14	34	557.403
#121	CEBPA	20	10	30	1419.337
#122	NFIL3	20	15	35	1959.384
#123	ELF1	20	16	36	1569.466
#124	RUNX3	20	10	30	266.645
#125	EGR2	20	8	28	1102.154
#126	MEOX1	19	12	31	1931.882
#127	MXD1	19	10	29	297.334
#128	PAX4	19	19	38	3230.887
#129	PHF1	19	13	32	941.685
#130	NR1D2	19	15	34	320.401
#131	HINFP	19	13	32	2094.528
#132	FOS	19	6	25	226.965
#133	SIX2	19	17	36	1160.998
#134	ZEB1	19	19	38	2167.948
#135	HMGA2	18	16	34	1064.378
#136	STAT6	18	14	32	2990.267
#137	MLLT10	18	10	28	703.759
#138	KLF6	18	14	32	839.401
#139	MYBL2	18	9	27	576.527
#140	FOXF2	18	8	26	4254.552
#141	PKNOX2	18	13	31	370.651
#142	HMBOX1	18	20	38	964.282
#143	SOX9	17	20	37	3292.327
#144	MAFF	17	3	20	281.486
#145	ISL1	17	22	39	2972.417
#146	ETV5	17	11	28	587.295
#147	SOX15	17	9	26	500.263
#148	SLC26A3	17	15	32	1264.598
#149	STAT1	17	8	25	369.744
#150	KLF4	17	13	30	3036.975
#151	MYC	17	12	29	671.442
#152	TFAP2B	17	9	26	116.706
#153	SMAD5	17	8	25	501.966
#154	JUNB	17	5	22	1189.754
#155	HOXB1	17	20	37	1610.451
#156	ELF4	17	9	26	1284.678
#157	HMGB2	17	7	24	1393.107
#158	CBFA2T2	17	14	31	423.015
#159	MSRB2	17	16	33	682.581
#160	ZNF135	16	10	26	1711.373
#161	ZXDC	16	12	28	1023.569
#162	HOXB2	16	15	31	704.353
#163	EN1	16	15	31	815.07
#164	NFATC4	16	20	36	1055.493
#165	MLXIPL	16	7	23	178.226
#166	PRRX2	16	15	31	1366.878
#167	NR2F2	16	15	31	764.026
#168	SMAD6	16	14	30	1135.901
#169	TFAM	16	17	33	561.456
#170	HOXA7	16	10	26	1015.649
#171	ZNF83	16	15	31	1071.566
#172	PPARG	16	15	31	549.458
#173	ELF5	16	11	27	1559.549
#174	TWIST1	16	16	32	297.571
#175	HOXA9	16	6	22	2082.638
#176	FOXN3	16	16	32	5912.302
#177	ZNF323	15	14	29	714.172
#178	SLC2A4RG	15	16	31	1113.851
#179	GAS7	15	18	33	1574.461
#180	ZNF202	15	17	32	2624.412
#181	KLF2	15	12	27	1976.216
#182	ARNTL	15	18	33	792.245
#183	FOXC1	15	10	25	696.756
#184	TLX2	15	20	35	3364.624
#185	TFEB	15	11	26	489.1
#186	E2F8	14	12	26	995.543
#187	ZNF131	14	20	34	994.617
#188	MYOD1	14	19	33	3780.136
#189	BCL6	14	17	31	2264.711
#190	FOSB	14	3	17	77.799
#191	E2F5	14	15	29	991.804
#192	ERG	14	13	27	390.007
#193	MEIS2	14	12	26	1586.779
#194	ESRRG	14	17	31	417.072
#195	SOX11	14	13	27	390.194
#196	BTG2	14	14	28	2174.364
#197	HES1	14	11	25	883.2
#198	SOX5	13	21	34	1871.098
#199	TCF7L2	13	21	34	2398.119
#200	GATA6	13	15	28	1237.303
#201	OVOL1	13	14	27	705.239
#202	MBD1	13	12	25	694.14
#203	NR5A1	13	22	35	842.639
#204	ZNF394	13	14	27	1118.058
#205	PROX1	13	12	25	334.778
#206	HNF4G	13	21	34	2040.818
#207	SPI1	13	13	26	233.385
#208	TSC22D3	13	16	29	1436.076
#209	TAL1	13	15	28	4647.56
#210	MYCL1	13	18	31	1699.681
#211	PRDM1	13	17	30	284.036
#212	GABPA	13	16	29	1069.951
#213	GTF2H3	13	17	30	2891.859
#214	IRF7	13	11	24	266.26
#215	HSF2	13	16	29	2013.628
#216	HOXA4	12	14	26	3281.313
#217	TFEC	12	12	24	651.098
#218	CITED1	12	10	22	838.998
#219	RXRA	12	21	33	10251.313
#220	SOX18	12	20	32	943.354
#221	TP53	12	9	21	648.788
#222	ATF3	12	5	17	340.17
#223	NR4A2	12	8	20	822.949
#224	ZNF444	12	19	31	670.643
#225	ELK3	12	18	30	1278.257
#226	ECSIT	12	15	27	691.554
#227	PEG3	12	13	25	796.348
#228	GATA4	12	12	24	1936.717
#229	LMO4	12	11	23	553.558
#230	MLL	12	18	30	1417.465
#231	HOXA10	12	17	29	1294.172
#232	HOXA11	12	11	23	1409.484
#233	SOX2	12	9	21	123.4
#234	RUNX1T1	12	18	30	2820.447
#235	LZTS1	11	18	29	1228.042
#236	HOXA5	11	18	29	577.544
#237	TBX2	11	11	22	262.729
#238	HOXD9	11	16	27	802.901
#239	RORB	11	20	31	2545.503
#240	GRHL2	11	17	28	406.047
#241	YEATS4	11	18	29	2731.231
#242	SOX13	11	6	17	289.742
#243	CEBPD	11	8	19	174.934
#244	RUNX2	11	22	33	1058.978
#245	HEY1	11	18	29	1055.327
#246	TBX6	11	19	30	1977.378
#247	KLF12	11	18	29	7140.792
#248	LHX6	11	18	29	2373.112
#249	C2orf3	11	20	31	1179.794
#250	LHX2	11	16	27	340.524
#251	SP1	10	16	26	857.747
#252	MMP14	10	15	25	272.414
#253	E2F4	10	19	29	1247.595
#254	PPBPL2	10	19	29	4126.98
#255	HNF1A	10	10	20	422.825
#256	ZNF117	10	25	35	906.176
#257	ZSCAN2	10	20	30	921.765
#258	PAX6	10	14	24	690.636
#259	ZNF41	10	19	29	1479.159
#260	WT1	10	17	27	1073.24
#261	FOXO1	10	19	29	442.494
#262	SIM1	10	21	31	551.505
#263	ZFPM2	10	13	23	213.241
#264	PPARD	10	21	31	1448.672
#265	NPAS2	10	17	27	2548.532
#266	ETV3	10	15	25	667.927
#267	TBX19	10	17	27	732.237
#268	NKX3-2	10	11	21	879.659
#269	ONECUT2	10	16	26	1893.054
#270	TBX4	10	8	18	478.372
#271	ZNF167	10	22	32	812.437
#272	ZKSCAN1	10	19	29	1522.56
#273	TBX10	10	13	23	1560.047
#274	PGR	10	10	20	98.921
#275	ZSCAN16	10	17	27	1591.038
#276	POU3F1	10	20	30	3485.182
#277	NFE2L3	10	17	27	1312.122
#278	NR2F6	10	16	26	1550.979
#279	SATB2	10	14	24	2247.454
#280	SREBF1	10	9	19	536.239
#281	E2F1	10	15	25	179.135
#282	JUN	10	15	25	457.614
#283	ESRRA	10	18	28	3251.582
#284	TFAP4	10	20	30	2060.762
#285	HR	10	18	28	937.33
#286	ZIC1	9	15	24	2479.278
#287	CDKN2A	9	18	27	3275.058
#288	NFIB	9	24	33	2638.628
#289	EGR3	9	10	19	1232.269
#290	HIRA	9	12	21	1347.753
#291	MNX1	9	17	26	624.483
#292	ZNF643	9	20	29	2041.344
#293	SIX1	9	9	18	73.917
#294	TEAD4	9	14	23	299.678
#295	NFIX	9	20	29	3918.473
#296	ZNF93	9	20	29	803.277
#297	HOXB9	9	15	24	483.376
#298	GLI2	9	23	32	3961.289
#299	RB1	9	19	28	784.276
#300	FOXO3	9	9	18	138.834
#301	NR5A2	9	12	21	181.107
#302	ZHX3	9	13	22	2618.009
#303	MYT1L	9	18	27	1283.166
#304	RARA	9	12	21	299.004
#305	ONECUT1	9	20	29	4108.884
#306	FOXI1	9	15	24	119.082
#307	TSHZ2	9	24	33	3064.427
#308	NFYA	9	19	28	1166.195
#309	NEUROD1	8	16	24	2927.632
#310	FOXH1	8	13	21	643.185
#311	MYT1	8	20	28	1089.973
#312	GABPB1	8	19	27	555.478
#313	RCAN1	8	21	29	1975.564
#314	STAT2	8	23	31	1165.055
#315	TAF12	8	26	34	1422.117
#316	HOXC13	8	11	19	563.415
#317	FOXD3	8	19	27	1002.763
#318	THRA	8	18	26	1546.15
#319	ZNF154	8	16	24	228.828
#320	NKX2-8	8	12	20	285.908
#321	WNT5A	8	19	27	253.045
#322	ZNF238	8	23	31	4946.533
#323	MYF6	8	12	20	556.207
#324	HOXA2	8	15	23	268.658
#325	SOX30	8	20	28	1762.31
#326	TCF3	8	17	25	544
#327	CEBPE	8	23	31	3187.106
#328	POU2F2	8	18	26	494.551
#329	IRX4	8	11	19	406.459
#330	ZNF287	8	18	26	7375.057
#331	NFAT5	8	11	19	325.993
#332	ATOH1	8	18	26	751.251
#333	NR2F1	8	21	29	559.409
#334	CUX2	8	17	25	248.652
#335	MSX2	8	15	23	356.169
#336	TFAP2C	7	16	23	113.082
#337	HOXB13	7	22	29	1386.539
#338	HESX1	7	20	27	3349.363
#339	IKZF1	7	18	25	396.012
#340	ATF5	7	23	30	1553.312
#341	AHR	7	15	22	500.19
#342	HOXD1	7	26	33	2538.352
#343	FOXD1	7	16	23	906.808
#344	TBX5	7	21	28	4051.604
#345	HNF4A	7	15	22	456.563
#346	RERE	7	14	21	299.049
#347	RARG	7	24	31	1093.702
#348	EGR1	7	14	21	364.185
#349	NR4A3	7	8	15	1027.715
#350	NR2C1	7	22	29	584.167
#351	PAX5	7	20	27	923.409
#352	FOXD2	7	19	26	1453.722
#353	T	7	17	24	4412.864
#354	VDR	7	18	25	1529.719
#355	PITX2	7	17	24	687.295
#356	PBX3	7	14	21	159.709
#357	ATF6B	7	19	26	876.522
#358	ARNT2	7	16	23	326.786
#359	ZNF80	7	21	28	2332.193
#360	IKZF3	7	20	27	3209.189
#361	POU3F4	6	19	25	2793.479
#362	HSF4	6	23	29	956.66
#363	CRX	6	17	23	323.708
#364	NANOG	6	13	19	888.404
#365	ZNF157	6	17	23	962.607
#366	HOXB6	6	14	20	213.619
#367	EN2	6	20	26	980.927
#368	ZNF236	6	18	24	664.136
#369	ZNF215	6	20	26	520.944
#370	GATA2	6	21	27	1471.306
#371	HOXB7	6	8	14	176.055
#372	FUBP1	6	15	21	320.702
#373	DMRT1	6	23	29	1002.905
#374	GBX2	6	17	23	2487.62
#375	BRD8	6	21	27	1260.863
#376	TAF1B	6	18	24	400.193
#377	PPARA	6	20	26	2218.432
#378	HOXC5	6	20	26	647.734
#379	ZNF165	6	19	25	961.579
#380	ZNF155	6	21	27	792.159
#381	PAX3	6	16	22	812.679
#382	NR6A1	6	14	20	478.092
#383	DLX2	6	23	29	724.542
#384	POU3F3	6	23	29	833.557
#385	GSC2	6	24	30	596.575
#386	USF2	5	22	27	667.401
#387	GCM1	5	21	26	418.813
#388	ZNF134	5	20	25	216.406
#389	HOXB3	5	12	17	215.322
#390	RBPJL	5	17	22	856.335
#391	NFX1	5	20	25	1186.046
#392	YY1	5	17	22	361.495
#393	NFKB2	5	18	23	552.48
#394	ASCL2	5	16	21	340.714
#395	HOXB8	5	20	25	912.997
#396	HMX1	5	21	26	1090.222
#397	PHOX2A	5	23	28	1108.556
#398	ZFP36L1	5	20	25	606.062
#399	SNAPC5	5	20	25	3163.147
#400	EMX1	5	18	23	748.781
#401	CSRNP3	5	13	18	179.38
#402	MSC	5	23	28	657.655
#403	FOXG1	5	23	28	637.998
#404	CREBBP	5	20	25	418.697
#405	NR2E1	5	19	24	2268.609
#406	ETV4	5	15	20	280.328
#407	TSC22D2	5	22	27	4577.401
#408	IRF4	5	17	22	833.785
#409	ALX4	5	14	19	729.733
#410	REST	5	13	18	321.196
#411	PRDM2	5	26	31	1920.634
#412	NR0B1	5	17	22	722.062
#413	DLX6	5	20	25	1417.699
#414	HOXC8	5	9	14	28.435
#415	FOXO4	5	17	22	281.406
#416	TEF	5	23	28	569.58
#417	PLAG1	5	17	22	74.936
#418	FOXL2	5	15	20	735.937
#419	ASCL1	5	20	25	1787.749
#420	POU4F1	5	21	26	755.363
#421	TRIM25	5	19	24	382.761
#422	ZNF639	5	18	23	682.403
#423	HEY2	5	26	31	324.608
#424	ZIC3	5	18	23	665.179
#425	HOXD11	4	17	21	268.369
#426	PKNOX1	4	19	23	126.848
#427	STRN3	4	16	20	197.41
#428	ALX3	4	19	23	1588.331
#429	HOXA3	4	14	18	268.014
#430	ESRRB	4	29	33	507.587
#431	TFDP2	4	16	20	461.344
#432	PTH	4	18	22	882.712
#433	PAX7	4	20	24	376.985
#434	NRL	4	22	26	120.567
#435	MYF5	4	21	25	858.414
#436	RFXAP	4	17	21	806.567
#437	CREB5	4	29	33	488.64
#438	SMAD9	4	11	15	598.411
#439	NEUROG1	4	23	27	695.173
#440	SCRT1	4	18	22	542.666
#441	ELK1	4	26	30	1062.751
#442	ETV2	4	17	21	676.347
#443	E2F2	4	23	27	521.413
#444	POU4F3	4	24	28	472.652
#445	TBX1	4	18	22	120.707
#446	NPAS1	4	22	26	551.124
#447	SCAND2	4	20	24	339.33
#448	TLX3	4	16	20	369.02
#449	ARNT	4	17	21	1456.21
#450	HOXD13	4	19	23	1483.379
#451	BLZF1	4	18	22	536.058
#452	ZSCAN12	4	17	21	293.116
#453	HIC1	4	18	22	1057.871
#454	IRF5	4	16	20	283.616
#455	DBP	4	20	24	460.099
#456	HIF3A	4	19	23	503.365
#457	ZNF81	3	18	21	2570.58
#458	ERF	3	12	15	990.438
#459	TADA2A	3	24	27	324.396
#460	ZNF174	3	25	28	687.574
#461	LHX1	3	20	23	434.725
#462	NFE2	3	17	20	167.895
#463	ATF6	3	24	27	1083.084
#464	BATF3	3	20	23	831.114
#465	ST18	3	20	23	1152.727
#466	FOXB1	3	20	23	251.932
#467	POU2F3	3	20	23	175.103
#468	NR2C2	3	16	19	437.167
#469	ELK4	3	22	25	310.398
#470	FOXJ1	3	18	21	786.579
#471	LEF1	3	19	22	554.465
#472	PDX1	3	17	20	368.909
#473	BARX1	3	22	25	225.318
#474	POU3F2	3	20	23	1995.666
#475	ZFP37	3	21	24	180.135
#476	MAFK	3	20	23	265.278
#477	FOXP3	2	21	23	245.778
#478	SIX3	2	25	27	355.351
#479	SRY	2	20	22	589.74
#480	NR4A1	2	9	11	252.157
#481	POU5F1B	2	19	21	309.712
#482	NKX2-5	2	21	23	151.653
#483	ZNF3	2	17	19	48.848
#484	TCF15	2	27	29	1090.463
#485	SIM2	2	15	17	163.757
#486	KDM5B	2	22	24	504.443
#487	RARB	2	21	23	456
#488	HOXD3	2	20	22	911.844
#489	ESR2	2	22	24	138.889
#490	CREM	2	19	21	617.404
#491	NFATC1	1	17	18	395.44
#492	MYCN	1	14	15	23.027
#493	CREBZF	1	21	22	1378.572
#494	FOXC2	1	22	23	349.119
#495	EGR4	1	22	23	191.491
#496	TAF13	1	25	26	122.559
#497	OLIG2	1	15	16	93.524
#498	MEF2D	0	19	19	0
#499	TCF7	0	21	21	0
#500	POU1F1	0	20	20	0