Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	ATF3	55	3	58	177.533
#2	STAT4	52	10	62	3091.283
#3	POU4F2	51	7	58	1096.009
#4	ESRRA	47	2	49	257.632
#5	E2F4	43	8	51	2353.754
#6	POU1F1	42	10	52	991.628
#7	SMAD6	42	9	51	451.341
#8	PHF5A	40	3	43	2813.244
#9	ZNF93	38	4	42	645.259
#10	CBFB	38	1	39	157.096
#11	SPEN	37	15	52	5677.175
#12	MSRB2	36	9	45	827.993
#13	DBP	36	5	41	462.927
#14	HSF5	35	6	41	1506.022
#15	HOXB7	34	6	40	3753.626
#16	RFX3	34	8	42	2282.952
#17	ZSCAN4	33	8	41	1262.12
#18	KLF4	33	4	37	517.312
#19	SREBF2	32	4	36	4619.722
#20	C2orf3	32	6	38	1002.765
#21	IRX5	32	3	35	205.497
#22	TFAP2C	32	9	41	849.754
#23	SIX1	32	3	35	261.667
#24	HOXD11	31	5	36	381.663
#25	ETV3L	31	6	37	409.919
#26	CTCF	31	12	43	4747.431
#27	YY1	31	13	44	2715.948
#28	KLF6	31	2	33	70.789
#29	HESX1	31	8	39	455.811
#30	ZNF236	31	9	40	2219.541
#31	FOXH1	30	13	43	2212.358
#32	HCFC1	30	10	40	1157.982
#33	NME2	29	5	34	1446.638
#34	TFEC	29	6	35	525.24
#35	OVOL1	28	7	35	978.253
#36	TSC22D4	28	13	41	1470.497
#37	ZSCAN18	27	3	30	399.979
#38	FOXO1	27	4	31	200.029
#39	NKX2-1	27	8	35	919.943
#40	CREB3L3	27	12	39	973.1
#41	FOXJ2	27	11	38	810.224
#42	FOXL1	27	3	30	842.416
#43	HOXA4	27	11	38	1045.06
#44	TRIM29	27	9	36	696.118
#45	SNAI2	27	10	37	1999.472
#46	NKX2-3	26	3	29	767.623
#47	RFX1	26	11	37	1464.093
#48	MEF2D	26	3	29	3067.465
#49	GABPB1	26	13	39	2179.804
#50	NFE2L2	26	1	27	3198.457
#51	ESRRG	26	6	32	1286.694
#52	AR	25	4	29	1495.702
#53	CBFA2T3	25	2	27	379.704
#54	FOXP4	25	5	30	595.169
#55	ALS2CR8	24	3	27	121.108
#56	E2F1	24	6	30	2842.923
#57	ZNF135	24	3	27	145.074
#58	ZNF33B	24	4	28	297.617
#59	FOXC1	24	7	31	860.746
#60	NFIX	24	10	34	1012.641
#61	FOXQ1	24	6	30	1145.706
#62	LMO4	23	8	31	2521.834
#63	RAX2	23	12	35	2250.194
#64	POU6F1	23	4	27	639.483
#65	IRX6	23	4	27	355.465
#66	SIX4	23	10	33	4009.672
#67	ZKSCAN1	23	6	29	4201.124
#68	TBX2	22	2	24	392.404
#69	NKX6-2	22	3	25	999.1
#70	ZNF75D	22	15	37	1915.024
#71	GTF2I	22	8	30	531.535
#72	TCF7	22	8	30	720.33
#73	TAF4B	22	13	35	3221.707
#74	SUPT4H1	21	9	30	1157.457
#75	ZKSCAN4	21	4	25	535.633
#76	IRF2	21	3	24	368.83
#77	IRX4	21	11	32	1114.702
#78	STAT2	21	5	26	772.69
#79	ZGPAT	21	6	27	455.349
#80	ATF7	21	5	26	3634.082
#81	KDM5B	20	12	32	894.989
#82	PITX1	20	8	28	1796.003
#83	MSL3	20	4	24	221.67
#84	CREBL2	20	10	30	1437.553
#85	HOXB2	20	7	27	551.062
#86	MTA1	20	8	28	615.969
#87	RELB	20	12	32	461.173
#88	PA2G4	20	19	39	2524.836
#89	FOXA1	20	9	29	1148.573
#90	SCML2	20	12	32	1494.703
#91	E2F7	20	3	23	102.08
#92	EVX1	20	17	37	1519.351
#93	ZNF197	20	2	22	3053.824
#94	DLX3	20	7	27	1415.524
#95	TARDBP	20	16	36	2433.116
#96	EGR3	20	14	34	1146.512
#97	SOX30	20	4	24	1236.844
#98	SRF	19	6	25	439.693
#99	TAF5L	19	9	28	1969.843
#100	STAT6	19	4	23	146.173
#101	ZNF277	19	12	31	1647.257
#102	SOX6	19	8	27	1053.641
#103	PPARG	19	8	27	1333.998
#104	SALL1	18	15	33	1260.114
#105	SCAND3	18	17	35	4501.716
#106	ADNP2	18	8	26	260.639
#107	HIF3A	18	10	28	1790.909
#108	MAFK	18	8	26	710.748
#109	VDR	18	6	24	170.656
#110	VAX2	18	7	25	203.156
#111	TFAP2B	18	11	29	1986.294
#112	NR1H4	18	5	23	4149.078
#113	AFF4	18	13	31	5422.383
#114	MNX1	18	7	25	4708.522
#115	CBL	18	17	35	1514.458
#116	HMGA1	18	9	27	750.385
#117	CTNNB1	18	8	26	1409.288
#118	TBX3	18	12	30	1662.825
#119	CUX2	18	12	30	1344.085
#120	SOLH	17	2	19	93.786
#121	ZSCAN16	17	11	28	956.386
#122	ZEB1	17	5	22	5254.286
#123	ST18	17	10	27	917.711
#124	HDAC2	17	14	31	1640.399
#125	VSX1	17	7	24	11272.063
#126	NR3C1	17	2	19	161.482
#127	ZFP36L1	17	8	25	854.08
#128	POU3F4	17	11	28	692.424
#129	NPAS1	17	6	23	393.867
#130	TSHZ3	17	12	29	1877.881
#131	MMP14	17	3	20	243.486
#132	SOX13	17	5	22	263.959
#133	CTBP1	17	13	30	2239.647
#134	TGIF2	17	16	33	2681.098
#135	NR2E3	17	11	28	552.813
#136	MBD1	17	12	29	1647.005
#137	ZSCAN1	17	10	27	1514.468
#138	PKNOX1	17	4	21	68.685
#139	YEATS4	17	8	25	454.567
#140	TBX19	17	4	21	515.602
#141	BCL11B	17	8	25	3317.849
#142	LASS6	16	10	26	1278.498
#143	IKZF3	16	11	27	612.416
#144	MESP1	16	11	27	1836.532
#145	SMAD4	16	17	33	993.302
#146	ETV6	16	5	21	760.446
#147	ZNF133	16	8	24	2053.654
#148	SIN3A	16	5	21	413.626
#149	NR1D2	16	9	25	1922.773
#150	MYC	16	7	23	437.294
#151	IRF7	16	8	24	385.558
#152	JUNB	16	9	25	1654.122
#153	GATA1	16	3	19	76.893
#154	RELA	16	12	28	493.945
#155	EGR2	16	10	26	510.053
#156	SPI1	16	11	27	2408.176
#157	ZNF24	15	11	26	1608.634
#158	HOXC4	15	13	28	898.917
#159	HIRA	15	3	18	107.948
#160	NR1H3	15	13	28	832.427
#161	NR1D1	15	7	22	4288.579
#162	MLXIPL	15	3	18	2359.58
#163	THRB	15	10	25	5063.512
#164	IRF8	15	10	25	1788.421
#165	MECOM	15	15	30	705.474
#166	HDAC1	15	7	22	468.145
#167	KLF7	15	14	29	1312.446
#168	SMAD3	15	15	30	1506.224
#169	SIM2	15	7	22	3474.659
#170	ZNF193	15	13	28	707.348
#171	TAL1	15	14	29	1266.603
#172	CREB3L2	14	14	28	485.024
#173	XBP1	14	11	25	1707.623
#174	HES6	14	4	18	816.525
#175	ELF4	14	6	20	121.751
#176	ZNF37A	14	10	24	4694.268
#177	EBF1	14	8	22	901.192
#178	HOXC13	14	6	20	133.594
#179	POU3F1	14	16	30	2772.388
#180	IRF5	14	9	23	1289.002
#181	TWIST1	14	10	24	1491.012
#182	TFE3	14	11	25	1637.499
#183	LASS2	14	5	19	1639.819
#184	MAFA	14	6	20	113.787
#185	SMAD2	14	18	32	2793.495
#186	ERF	14	12	26	6325.228
#187	C12orf28	14	13	27	4287.842
#188	LHX1	13	11	24	678.668
#189	HOXA1	13	14	27	267.116
#190	NFYA	13	12	25	665.972
#191	GLIS3	13	17	30	9934.553
#192	SCAND1	13	13	26	3773.933
#193	MTF1	13	10	23	393.111
#194	IKZF4	13	12	25	2059.489
#195	ASCL2	13	7	20	958.386
#196	TEAD3	13	7	20	1182.448
#197	ZNF496	13	10	23	279.021
#198	TP53	13	9	22	531.338
#199	TBP	13	5	18	1689.541
#200	SP140	13	11	24	1939.868
#201	GATAD1	13	9	22	3041.373
#202	NR2E1	13	7	20	1021.979
#203	FOXK2	13	15	28	2023.335
#204	RCOR1	12	5	17	127.804
#205	L3MBTL4	12	9	21	731.396
#206	NFIA	12	11	23	1257.583
#207	MAF	12	18	30	715.993
#208	ZNF165	12	7	19	352.441
#209	UBN1	12	16	28	1455.364
#210	NFATC1	12	10	22	954.077
#211	MEIS3	12	15	27	1188.496
#212	HOXC11	12	7	19	1009.843
#213	POU5F1	12	13	25	4245.808
#214	TCF19	12	7	19	303.016
#215	GLIS2	12	10	22	2237.404
#216	HINFP	12	17	29	442.346
#217	MYCL1	12	9	21	624.034
#218	KLF12	12	6	18	740.75
#219	LHX9	12	9	21	3368.927
#220	EMX1	12	10	22	770.271
#221	DLX6	12	18	30	1475.098
#222	HOXA5	12	9	21	174.876
#223	POU2F3	12	16	28	3322.197
#224	GSC2	11	9	20	1231.338
#225	HOXB4	11	14	25	2290.925
#226	TGIF2LY	11	10	21	5966.17
#227	PPARD	11	15	26	1319.075
#228	ZNF131	11	16	27	636.07
#229	HNRNPK	11	6	17	3198.339
#230	PLSCR1	11	13	24	937.517
#231	POU4F3	11	13	24	3938.292
#232	ESR2	11	14	25	461.098
#233	CITED2	11	8	19	961.29
#234	ZKSCAN5	11	7	18	713.639
#235	TP63	11	13	24	336.731
#236	SMAD5	11	8	19	1710.117
#237	HMGB1	11	15	26	670.897
#238	TP73	11	7	18	641.216
#239	HOXB8	11	14	25	1381.608
#240	ZNF498	11	9	20	1444.076
#241	SCML1	11	13	24	1176.908
#242	STRN3	11	13	24	620.131
#243	ZBTB38	11	14	25	4486.7
#244	NR0B1	11	10	21	2590.671
#245	HOPX	10	13	23	514.531
#246	TEF	10	14	24	1703.964
#247	CDX2	10	9	19	1297.722
#248	HOXB3	10	11	21	529.912
#249	TBX5	10	19	29	868.464
#250	ZXDC	10	8	18	539.478
#251	GCM1	10	15	25	1848.944
#252	HES1	10	11	21	4391.856
#253	ARX	10	13	23	2262.747
#254	RORA	10	14	24	3429.137
#255	OTX1	10	13	23	459.454
#256	STAT1	10	9	19	128.054
#257	LHX6	10	17	27	1143.787
#258	ESR1	10	12	22	1055.187
#259	MLLT10	10	8	18	5946.036
#260	RBPJ	10	12	22	1152.671
#261	PHOX2B	10	9	19	849.848
#262	ZNF397	10	10	20	1361.122
#263	SATB2	10	10	20	1595.573
#264	ETV7	10	12	22	376.015
#265	ATF6	10	10	20	1133.14
#266	ZXDA	9	10	19	462.618
#267	ZSCAN2	9	12	21	1711.046
#268	RCAN1	9	12	21	316.48
#269	KLF5	9	13	22	526.723
#270	FOXA2	9	15	24	1997.14
#271	CNBP	9	17	26	476.294
#272	SP3	9	15	24	437.046
#273	NR1I3	9	15	24	333.197
#274	ETV5	9	17	26	912.744
#275	EPAS1	9	9	18	157.733
#276	TCF12	9	19	28	408.988
#277	TSC22D2	9	7	16	1472.567
#278	ELK4	9	7	16	291.691
#279	ZNF217	9	11	20	332.228
#280	NKX2-5	9	10	19	1460.532
#281	ZNF134	9	15	24	2015.042
#282	THRA	9	8	17	395.209
#283	ARNTL2	9	16	25	7815.177
#284	RUNX2	8	11	19	546.873
#285	MSC	8	6	14	2072.624
#286	AHCTF1	8	17	25	1196.86
#287	ZNF483	8	15	23	235.471
#288	BATF3	8	16	24	228.25
#289	ZNF167	8	9	17	244.366
#290	RUNX1	8	12	20	215.515
#291	TFAP2A	8	19	27	491.688
#292	TFAP4	8	12	20	222.058
#293	ZNF33A	8	13	21	479.367
#294	FOXO4	8	12	20	974.978
#295	HIF1A	8	11	19	3658.793
#296	NFIB	8	16	24	841.532
#297	TBX10	8	8	16	1353.21
#298	SHOX	8	15	23	11204.368
#299	MYCN	8	19	27	464.516
#300	GTF2IRD1	8	16	24	218.641
#301	SIX3	8	15	23	1998.913
#302	ERG	8	14	22	232.349
#303	MXD1	7	15	22	1245.437
#304	TRIM22	7	14	21	898.843
#305	KLF2	7	13	20	333.348
#306	TCEAL1	7	10	17	1295.093
#307	FOXD4	7	14	21	353.256
#308	ZNF81	7	6	13	2486.294
#309	TCFL5	7	18	25	426.662
#310	HOXA10	7	14	21	630.596
#311	ATF4	7	10	17	688.925
#312	ZNF90	7	18	25	352.843
#313	SPDEF	7	10	17	90.439
#314	AFF1	7	14	21	972.023
#315	SIX2	7	15	22	702.857
#316	ZNF213	7	11	18	366.894
#317	BTAF1	7	15	22	325.344
#318	ZBTB25	7	11	18	466.055
#319	TFAM	7	15	22	480.547
#320	JUN	7	16	23	2284.214
#321	ETV1	7	12	19	420.536
#322	HEY2	6	13	19	946.361
#323	POU2F1	6	14	20	321.965
#324	GATAD2A	6	13	19	210.721
#325	UHRF1	6	20	26	3047.394
#326	DMTF1	6	16	22	334.777
#327	KLF11	6	23	29	360.846
#328	TCF7L2	6	14	20	361.622
#329	MEIS2	6	15	21	535.386
#330	FEV	6	11	17	55.31
#331	GABPA	6	17	23	359.592
#332	ZBTB48	6	13	19	1168.014
#333	CDKN2A	6	15	21	830.273
#334	ONECUT1	6	12	18	323.3
#335	C1orf85	6	11	17	322.808
#336	ZNF281	6	15	21	343.898
#337	STAT3	6	16	22	1231.809
#338	NFAT5	6	8	14	150.696
#339	E4F1	6	10	16	1302.605
#340	ZNF202	6	11	17	713.454
#341	TBR1	5	17	22	200.762
#342	PRDM2	5	20	25	547.359
#343	PPARA	5	7	12	715.006
#344	MZF1	5	22	27	462.876
#345	NEUROD1	5	16	21	153.992
#346	KCNH8	5	12	17	189.707
#347	HOXA13	5	16	21	135.781
#348	NANOGP1	5	16	21	174.932
#349	HOXD1	5	11	16	157.232
#350	TRERF1	5	9	14	1044.376
#351	MSX2	5	14	19	1790.326
#352	ZSCAN21	5	21	26	211.14
#353	RB1	5	21	26	2636.49
#354	SIX6	5	10	15	270.41
#355	ZNF445	5	6	11	98.442
#356	EGR1	5	7	12	2841.173
#357	ZNF174	5	14	19	115.241
#358	DLX2	5	12	17	104.935
#359	ELK1	5	10	15	212.949
#360	DLX1	5	10	15	308.093
#361	BLZF1	5	13	18	177.793
#362	HOXA6	4	10	14	117.865
#363	FBXW7	4	13	17	68.073
#364	TAF1B	4	18	22	83.154
#365	CREM	4	14	18	456.272
#366	SOX17	4	11	15	135.524
#367	FOXP3	4	13	17	175.655
#368	NFYC	4	16	20	1021.037
#369	NR2F2	4	16	20	596.903
#370	POU2F2	4	18	22	343.622
#371	ZNF367	4	17	21	169.658
#372	ECSIT	4	21	25	197.302
#373	CSDA	4	5	9	65.763
#374	NFX1	4	16	20	133.596
#375	SOX7	4	8	12	38.57
#376	ELF1	4	15	19	188.232
#377	RERE	4	22	26	222.384
#378	HES5	4	15	19	243.027
#379	SOX4	4	17	21	686.086
#380	TCF4	4	16	20	261.713
#381	ZHX3	4	11	15	70.735
#382	BATF	4	13	17	1011.651
#383	PLAGL2	4	26	30	236.56
#384	SOX10	4	12	16	120.484
#385	RORB	4	17	21	1189.776
#386	FOXE1	4	8	12	5.301
#387	HMX2	4	11	15	159.137
#388	E2F5	4	16	20	79.518
#389	HNF1A	4	11	15	195.941
#390	MSX1	4	18	22	357.919
#391	FOXN3	4	15	19	111.568
#392	SLC2A4RG	4	10	14	1644.662
#393	IRF3	4	10	14	580.215
#394	REXO4	4	13	17	1053.85
#395	NFKB1	4	19	23	820.998
#396	BARHL2	4	17	21	221.076
#397	ZRANB2	4	11	15	166.516
#398	NR2F1	4	17	21	118.017
#399	SUPT6H	3	9	12	727.918
#400	HOXC9	3	10	13	222.773
#401	ZNF45	3	23	26	175.476
#402	MLL	3	16	19	205.773
#403	TAF13	3	14	17	119.104
#404	FOXM1	3	11	14	195.035
#405	ZEB2	3	15	18	326.796
#406	KLF3	3	17	20	157.155
#407	NFYB	3	6	9	21.691
#408	LHX4	3	9	12	837.803
#409	IRX1	3	24	27	236.399
#410	SNAI3	3	14	17	141.067
#411	ZNF238	3	21	24	339.293
#412	WT1	3	15	18	157.397
#413	NOTCH1	3	22	25	197.422
#414	PURA	3	17	20	885.142
#415	ZNF19	3	16	19	90.863
#416	MYOG	3	10	13	233.36
#417	CREB3L1	3	19	22	119.211
#418	ZNF138	3	18	21	4682.345
#419	MITF	3	20	23	87.557
#420	E2F3	3	17	20	118.032
#421	PURB	3	17	20	113.958
#422	MYF6	3	25	28	616.912
#423	ASCL1	3	12	15	88.673
#424	TEAD4	3	15	18	156.511
#425	ZIC1	3	17	20	297.944
#426	BTG2	3	14	17	76.043
#427	ZFHX4	3	19	22	166.657
#428	TRIM28	3	14	17	150.399
#429	NPAT	3	14	17	312.071
#430	FOSB	3	10	13	23.22
#431	HOXD9	3	10	13	160.371
#432	FOXL2	3	11	14	4293.568
#433	TRPS1	2	22	24	94.914
#434	SIM1	2	16	18	70.594
#435	ZNF175	2	17	19	171.233
#436	SP1	2	20	22	63.734
#437	CSRNP1	2	10	12	20.468
#438	CREB3	2	23	25	148.002
#439	MAFB	2	19	21	493.39
#440	EN1	2	23	25	382.213
#441	RNF4	2	10	12	230.418
#442	HOXD4	2	12	14	278.23
#443	PROX1	2	12	14	278.689
#444	FOXP2	2	14	16	71.143
#445	TSHZ1	2	23	25	215.207
#446	KLF15	2	14	16	33.391
#447	RFX5	2	19	21	210.799
#448	GTF2H4	2	21	23	88.78
#449	HMGA2	2	19	21	73.942
#450	SOX11	2	18	20	93.822
#451	FOXJ3	2	16	18	1191.187
#452	ELF5	2	19	21	120.473
#453	ETS2	2	16	18	223.721
#454	TFEB	2	22	24	120.707
#455	LZTR1	2	26	28	159.688
#456	BUD31	2	16	18	35.611
#457	PBX1	2	23	25	70.71
#458	GAS7	2	17	19	85.782
#459	ZNF274	2	19	21	66.536
#460	TAF7	2	15	17	478.687
#461	LCOR	2	13	15	25.417
#462	CEBPB	2	16	18	132.018
#463	GBX1	2	15	17	49.95
#464	ZNF263	2	22	24	236.189
#465	HNF1B	1	21	22	100.083
#466	IRX2	1	19	20	38.672
#467	ZSCAN5A	1	17	18	40.654
#468	MGA	1	15	16	16.113
#469	TSHZ2	1	9	10	1.833
#470	TLX1	1	17	18	44.922
#471	ZNF215	1	20	21	64.223
#472	UBP1	1	16	17	42.269
#473	TCF25	1	23	24	161.559
#474	PKNOX2	1	22	23	126.919
#475	RUNX1T1	1	20	21	70.504
#476	NFKB2	1	24	25	157.897
#477	RUNX3	1	21	22	40.192
#478	ATF2	1	22	23	76.008
#479	ZIC3	1	17	18	30.46
#480	MTA3	1	11	12	15.154
#481	HNF4G	1	20	21	42.892
#482	FOXC2	1	15	16	29.458
#483	STAT5B	1	24	25	40.279
#484	PAX5	1	16	17	18.059
#485	ZNF434	1	18	19	10487.93
#486	GCFC1	1	17	18	29.138
#487	ZNF69	1	17	18	66.499
#488	GRHL2	1	21	22	38.591
#489	IKZF1	1	16	17	67.717
#490	ZIC5	1	17	18	114.529
#491	FOXN2	0	26	26	0
#492	PBX4	0	18	18	0
#493	CEBPA	0	22	22	0
#494	ZNF187	0	21	21	0
#495	ELF2	0	24	24	0
#496	KLF10	0	27	27	0
#497	AEBP1	0	18	18	0
#498	DDIT3	0	22	22	0
#499	CREBBP	0	18	18	0
#500	FOXD1	0	20	20	0