Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	TBX2	70	2	72	102.192
#2	ZNF3	69	3	72	551.738
#3	NOTCH1	68	0	68	0
#4	SOX1	64	4	68	678.924
#5	SP3	64	8	72	937.642
#6	ISL2	60	2	62	158.325
#7	RARA	60	6	66	184.878
#8	ZNF81	60	4	64	89.929
#9	MZF1	59	6	65	261.116
#10	MSX2	59	6	65	604.405
#11	MYBL2	57	11	68	4226.309
#12	ATF7	56	3	59	138.625
#13	FOXO1	53	4	57	97.025
#14	GABPA	53	9	62	4654.157
#15	SPEN	52	6	58	481.359
#16	POU2F2	52	5	57	707.24
#17	HMG20B	52	9	61	6267.421
#18	PBX2	50	7	57	922.547
#19	NFYA	49	5	54	3363.606
#20	NR2E3	49	5	54	200.098
#21	SOX15	48	6	54	1337.194
#22	NKX3-1	48	17	65	2144.524
#23	PCGF2	47	9	56	195.065
#24	ZNF445	46	4	50	139.221
#25	IKZF1	45	3	48	2614.312
#26	GLI3	45	10	55	547.37
#27	KDM5A	45	13	58	1480.879
#28	HOXC9	44	9	53	899.848
#29	HSF1	44	5	49	490.736
#30	TCF3	43	3	46	99.862
#31	MAFG	43	2	45	24.137
#32	NPAT	42	15	57	1350.927
#33	TRIM29	41	15	56	910.303
#34	NFATC2	41	7	48	232.338
#35	CBFA2T2	41	8	49	2611.005
#36	MEIS3	41	7	48	343.928
#37	TBX1	40	7	47	653.42
#38	SUPT6H	40	5	45	101.233
#39	TSHZ3	40	10	50	1379.501
#40	RORC	40	10	50	1432.683
#41	TFAP2C	40	4	44	254.868
#42	TADA2A	40	17	57	913.003
#43	TEAD1	39	7	46	1199.222
#44	ELF1	39	11	50	4382.212
#45	HMGA1	39	4	43	113.785
#46	GATA2	39	5	44	598.61
#47	STAT3	38	11	49	729.27
#48	DLX4	38	14	52	1524.909
#49	CREB3L3	37	10	47	328.663
#50	RUNX3	37	9	46	1292.147
#51	PBX3	37	13	50	1484.608
#52	NPAS1	37	20	57	1599.777
#53	MLLT10	37	14	51	2095.191
#54	TBX5	37	18	55	3969.308
#55	ZNF219	36	9	45	1417.474
#56	TFEB	36	14	50	702.198
#57	MYC	36	11	47	1837.313
#58	KLF16	36	11	47	303.339
#59	BHLHE41	36	2	38	104.165
#60	NR2F6	36	11	47	691.735
#61	MLL	35	10	45	486.018
#62	SMAD5	34	6	40	875.694
#63	SREBF1	34	20	54	2992.779
#64	HIF1A	33	8	41	422.016
#65	ZFP36L2	33	9	42	1863.091
#66	ST18	32	10	42	2239.739
#67	ESRRG	32	12	44	1079.041
#68	NFE2L2	32	16	48	891.512
#69	RXRB	32	2	34	45.786
#70	ARID4A	32	19	51	7970.253
#71	ATF6	32	7	39	777.847
#72	EGR4	32	13	45	1045.678
#73	TRPS1	32	10	42	1659.524
#74	TCF7L1	32	14	46	1678.363
#75	TFE3	31	5	36	67.035
#76	AEBP1	31	14	45	490.213
#77	SIX5	31	14	45	1313.61
#78	ARNTL2	31	16	47	1620.993
#79	PKNOX2	31	17	48	2119.11
#80	VSX1	30	11	41	336.588
#81	ZNF131	30	10	40	671.086
#82	HOXB6	30	15	45	1353.287
#83	ZNF169	30	16	46	6429.75
#84	KLF3	30	8	38	1028.807
#85	ARNTL	30	11	41	525.464
#86	MIXL1	30	11	41	2332.952
#87	BCL3	30	10	40	1640.49
#88	ZFP90	30	15	45	1687.205
#89	C2orf3	29	15	44	4592.334
#90	ATOH1	29	12	41	924.391
#91	BHLHE40	28	9	37	1620.304
#92	ZNF93	28	13	41	1078.864
#93	GATA4	28	20	48	2163.223
#94	PBX1	28	6	34	266.483
#95	BTG2	28	6	34	746.734
#96	RUNX1	28	11	39	795.291
#97	E2F2	28	11	39	1028.352
#98	TLX3	28	17	45	1550.145
#99	CDKN2A	27	21	48	4247.355
#100	SPIB	27	18	45	749.872
#101	HCFC1	27	16	43	1019.145
#102	BACH2	27	15	42	928.082
#103	ZNF75D	27	12	39	452.211
#104	PHF1	27	14	41	567.05
#105	HOXB7	26	8	34	480.766
#106	ZNF41	26	12	38	551.856
#107	MNX1	26	14	40	704.183
#108	KLF4	26	12	38	533.519
#109	NFKB2	26	13	39	457.543
#110	STAT2	26	14	40	642.012
#111	ETV6	26	11	37	312.055
#112	NFATC4	26	15	41	1186.425
#113	HOXA5	26	7	33	1123.308
#114	HHEX	26	21	47	2506.912
#115	AHCTF1	26	11	37	572.379
#116	HEY2	26	7	33	480.272
#117	MAF	25	7	32	1472.233
#118	CTBP1	25	19	44	778.121
#119	FOXK1	25	26	51	1564.441
#120	E2F8	25	6	31	1359.418
#121	TWIST1	25	9	34	678.501
#122	CREM	25	14	39	259.802
#123	FOXL1	25	17	42	2945.274
#124	POU6F2	25	12	37	2416.668
#125	PHTF1	24	27	51	2376.6
#126	JUN	24	12	36	464.194
#127	FOS	24	6	30	803.438
#128	NR3C2	24	14	38	1319.32
#129	MESP1	24	20	44	1604.81
#130	HOXD13	24	15	39	1335.941
#131	ZXDC	24	5	29	382.955
#132	MYF5	24	17	41	993.087
#133	PURB	24	17	41	1930.933
#134	IRF5	23	14	37	540.971
#135	SMAD6	23	13	36	531.378
#136	ZNF193	23	21	44	2068.254
#137	HOXD1	23	20	43	1181.597
#138	ELK1	23	11	34	554.899
#139	UHRF1	23	9	32	3923.101
#140	BATF	23	15	38	2934.686
#141	RERE	23	19	42	1076.477
#142	ZIC1	22	14	36	782.416
#143	FOXH1	22	14	36	981.117
#144	ZNF438	22	12	34	2029.535
#145	TRIM22	22	14	36	342.135
#146	MEIS2	22	12	34	1132.151
#147	KLF2	22	14	36	1035.757
#148	JUNB	22	6	28	1314.556
#149	RB1	22	14	36	799.85
#150	SLC2A4RG	22	22	44	1058.566
#151	TCF12	22	12	34	1085.712
#152	SNAPC5	22	19	41	948.173
#153	TCF4	22	9	31	1807.177
#154	POU6F1	22	10	32	304.564
#155	TCFL5	22	16	38	1777.429
#156	KLF9	21	10	31	1342.496
#157	ENO1	21	17	38	669.48
#158	ZBTB38	21	12	33	2135.724
#159	SMAD1	21	14	35	1877.333
#160	AHR	21	16	37	843.052
#161	SPI1	21	8	29	234.407
#162	ESR2	21	12	33	865.231
#163	FOXM1	21	7	28	457.141
#164	ELF5	21	19	40	657.488
#165	MLXIPL	20	13	33	592.641
#166	ETS1	20	14	34	1131.347
#167	MKX	20	14	34	1655.427
#168	OTX2	20	16	36	874.626
#169	ZSCAN18	20	10	30	450.165
#170	NR4A2	20	12	32	690.746
#171	SOX9	20	23	43	2640.999
#172	ATF6B	20	14	34	819.252
#173	WT1	20	19	39	2433.984
#174	ZNF446	20	16	36	913.021
#175	ONECUT3	20	15	35	875.741
#176	HOXB2	20	24	44	4448.608
#177	TBX21	19	20	39	1836.43
#178	NR4A1	19	15	34	3034.14
#179	SOX5	19	23	42	2446.552
#180	ZEB2	19	13	32	1848.549
#181	ZSCAN20	19	10	29	1429.123
#182	TFDP1	19	19	38	778.762
#183	PGBD1	19	13	32	557.251
#184	ELF4	19	19	38	2081.71
#185	ZNF174	19	19	38	515.792
#186	HOXA7	18	10	28	341.307
#187	PLAG1	18	12	30	1793.269
#188	NFE2L3	18	8	26	1783.658
#189	FOSL1	18	24	42	1621.097
#190	HES6	18	11	29	1488.13
#191	MMP14	18	20	38	581.722
#192	LASS6	18	12	30	550.483
#193	HES1	18	19	37	1220.807
#194	TULP4	18	17	35	858.156
#195	ZNF92	18	17	35	405.93
#196	FOXP1	18	20	38	1047.259
#197	ATF3	18	15	33	912.353
#198	HOXD4	18	14	32	834.73
#199	STAT1	18	26	44	3953.236
#200	YY1	17	19	36	436.377
#201	TLX2	17	14	31	604.875
#202	SMAD4	17	16	33	701.817
#203	ZNF287	17	19	36	891.171
#204	BATF2	17	23	40	1090.017
#205	FOXO3	17	10	27	87.745
#206	NPAS2	17	17	34	1599.998
#207	FOSB	17	8	25	592.625
#208	ZNF215	17	12	29	810.466
#209	REST	17	22	39	933.348
#210	RARB	17	17	34	358.743
#211	MYT1	17	21	38	782.88
#212	MSRB2	17	15	32	446.133
#213	ZNF434	17	15	32	1042.982
#214	ATF5	17	23	40	1323.233
#215	ZNF238	17	20	37	757.441
#216	NR2F2	17	20	37	2169.951
#217	ZNF157	16	14	30	327.86
#218	ARNT2	16	16	32	842.341
#219	NFIX	16	19	35	1449.921
#220	DLX3	16	21	37	1681.269
#221	ZFHX3	16	19	35	1156.102
#222	SATB1	16	17	33	1059.464
#223	EGR2	16	11	27	738.039
#224	GLIS3	16	16	32	707.024
#225	SCAND1	16	17	33	875.264
#226	SOX4	16	12	28	342.898
#227	CBL	16	20	36	772.017
#228	TRERF1	16	14	30	897.219
#229	DMBX1	16	21	37	1676.06
#230	NANOGNB	16	23	39	824.135
#231	IRX4	15	23	38	1357.541
#232	ZNF83	15	22	37	1544.458
#233	NFIC	15	13	28	206.2
#234	TFAP2A	15	18	33	443.331
#235	C11orf9	15	23	38	729.755
#236	TBX19	15	21	36	2011.12
#237	SOX30	15	23	38	1312.387
#238	FOXK2	15	28	43	2758.143
#239	POU2F3	15	17	32	605.945
#240	MNT	15	29	44	1781.541
#241	HNF4G	15	14	29	411.869
#242	GCM1	15	21	36	984.582
#243	TSC22D1	15	18	33	1477.268
#244	MBD1	15	14	29	534.279
#245	ZNF71	15	22	37	904.391
#246	ZNF643	15	24	39	1161.832
#247	RCOR1	15	23	38	1022.36
#248	ZNF85	15	21	36	1009.216
#249	ARNT	15	15	30	261.376
#250	SIX4	14	19	33	810.802
#251	TCF21	14	17	31	696.795
#252	IRF4	14	22	36	715.727
#253	ZFPM2	14	16	30	646.674
#254	PHOX2B	14	21	35	739.637
#255	KLF6	14	13	27	782.378
#256	DMRT2	14	25	39	994.785
#257	ZNF165	14	22	36	1638.491
#258	POU3F1	14	15	29	2347.715
#259	TP63	14	18	32	1051.432
#260	ZEB1	14	20	34	1180.61
#261	MAFB	14	17	31	1345.849
#262	ZNF396	14	15	29	793.698
#263	ZSCAN12	14	16	30	841.183
#264	POU4F1	13	21	34	1205.432
#265	HIF3A	13	25	38	1666.298
#266	ZIC2	13	22	35	336.052
#267	HESX1	13	27	40	1061.847
#268	FOXS1	13	21	34	793.816
#269	ZNF132	13	21	34	995.096
#270	OLIG2	13	18	31	1937.332
#271	TFDP2	13	19	32	826.116
#272	ZNF449	13	26	39	1266.132
#273	GAS7	12	25	37	1701.891
#274	LHX8	12	12	24	1325.952
#275	SOX2	12	21	33	965.672
#276	PITX1	12	17	29	595.969
#277	EGR1	12	7	19	413.214
#278	SIX1	12	20	32	774.967
#279	KLF12	12	19	31	596.059
#280	ZNF117	12	25	37	3116.336
#281	NR2F1	12	22	34	1716.724
#282	PROX1	12	26	38	1287.091
#283	EPAS1	12	20	32	720.953
#284	FOXA1	12	24	36	993.596
#285	STAT5B	12	16	28	414.656
#286	NKX3-2	12	13	25	543.592
#287	ZSCAN10	12	22	34	1499.974
#288	DLX6	12	17	29	866.302
#289	MAFF	12	25	37	959.783
#290	TAF1B	12	20	32	809.113
#291	ONECUT2	12	24	36	1850.915
#292	HMGB2	12	24	36	1005.463
#293	ZSCAN2	12	18	30	855.18
#294	NEUROD1	12	18	30	745.555
#295	ZNF197	12	23	35	1874.664
#296	PAX7	12	30	42	2160.885
#297	HIC1	11	27	38	3340.587
#298	TCF7L2	11	24	35	1307.216
#299	WNT5A	11	28	39	953.379
#300	TGIF1	11	30	41	987.682
#301	BLZF1	11	24	35	606.65
#302	GATAD2B	11	19	30	1405.165
#303	BCL6	11	24	35	1277.656
#304	IRX1	11	20	31	1226.519
#305	BATF3	11	21	32	799.134
#306	THRA	11	21	32	1284.772
#307	AFF4	11	15	26	420.369
#308	RUNX2	11	24	35	992.21
#309	SOX6	11	16	27	1072.248
#310	NR6A1	10	24	34	1107.148
#311	ETS2	10	20	30	1096.239
#312	FOXA3	10	20	30	923.788
#313	CSRNP3	10	26	36	1281.052
#314	PBX4	10	18	28	513.164
#315	ASCL1	10	18	28	985.338
#316	ZNF256	10	21	31	652.498
#317	ETV4	10	19	29	1334.586
#318	KLF15	10	16	26	611.633
#319	HOXA2	10	21	31	475.462
#320	ZSCAN1	10	18	28	1034.128
#321	TSC22D3	10	13	23	754.529
#322	NFAT5	10	23	33	1842.634
#323	NKX6-2	10	29	39	836.336
#324	ELK4	10	17	27	272.134
#325	NFIA	10	26	36	657.404
#326	ZNF148	10	21	31	793.225
#327	FOXO4	10	23	33	688.347
#328	KLF17	10	21	31	1500.282
#329	PITX2	10	26	36	1060.119
#330	FOXC1	10	25	35	957.538
#331	MEF2D	10	22	32	1257.215
#332	MECOM	9	21	30	704.26
#333	KLF5	9	20	29	893.287
#334	HES5	9	17	26	534.646
#335	GSX1	9	19	28	1241.129
#336	SALL2	9	22	31	665.414
#337	ARX	9	32	41	1486.794
#338	ZNF91	9	15	24	295.641
#339	SOX7	9	30	39	1244.625
#340	TBX3	9	27	36	2781.666
#341	SOX21	9	19	28	297.416
#342	SCAND2	9	35	44	1034.973
#343	TCF20	9	32	41	3705.102
#344	NR1H3	9	28	37	1695.391
#345	ALX3	9	30	39	3461.363
#346	HOXB8	9	21	30	2932.074
#347	CSDA	9	21	30	776.589
#348	NR4A3	9	16	25	746.883
#349	EGR3	9	19	28	2983.984
#350	LMX1B	9	18	27	575.655
#351	HEY1	9	24	33	1756.685
#352	IRF6	8	24	32	1465.154
#353	IRX5	8	30	38	929.989
#354	GATA3	8	22	30	968.769
#355	HOXA1	8	16	24	416.54
#356	POU3F2	8	14	22	109.379
#357	POU1F1	8	22	30	1701.213
#358	CREBZF	8	30	38	1015.496
#359	ZNF397	8	24	32	1052.353
#360	ELF3	8	18	26	708.78
#361	ZSCAN23	8	18	26	1040.266
#362	TSC22D2	8	24	32	2791.059
#363	EHF	8	19	27	613.169
#364	FOXD3	8	24	32	598.27
#365	FUBP1	8	25	33	703.728
#366	CEBPD	8	20	28	2516.931
#367	TSHZ2	8	28	36	733.451
#368	ZNF639	8	17	25	822.403
#369	LEF1	8	22	30	1581.739
#370	TFAP2B	8	24	32	2603.467
#371	C12orf28	8	18	26	395.317
#372	NR1H4	8	20	28	2438.586
#373	HOXD9	7	16	23	2486.253
#374	GLI2	7	22	29	842.22
#375	HOXD11	7	21	28	447.38
#376	RCOR2	7	20	27	728.973
#377	HOXA10	7	10	17	376.114
#378	ZNF19	7	25	32	1507.852
#379	SMAD9	7	22	29	883.405
#380	PAX6	7	24	31	969.985
#381	ERG	7	25	32	815.22
#382	FOXD1	7	24	31	701.662
#383	SPIC	7	26	33	980.266
#384	PAX3	7	31	38	2109.594
#385	ATF2	7	28	35	1610.606
#386	PLSCR1	7	26	33	526.549
#387	HNF4A	7	20	27	1900.443
#388	REL	7	24	31	616.508
#389	TEAD2	7	19	26	977.555
#390	FOXC2	7	23	30	1211.797
#391	ZFP36L1	7	20	27	717.474
#392	NANOG	7	18	25	245.581
#393	FOXE1	7	26	33	1126.865
#394	SALL1	7	24	31	1075.06
#395	ESR1	7	24	31	983.855
#396	NFE2	7	25	32	708.414
#397	NFATC1	7	21	28	234.241
#398	PPARA	7	20	27	774.057
#399	BACH1	7	23	30	792.673
#400	PEG3	6	31	37	1020.917
#401	ZNF207	6	21	27	1149.369
#402	TEAD4	6	26	32	940.644
#403	GATA6	6	16	22	182.113
#404	POU2F1	6	25	31	962.949
#405	IRX3	6	23	29	824.347
#406	ZNF154	6	24	30	663.153
#407	PAX8	6	29	35	1172.701
#408	MYNN	6	20	26	498.924
#409	LMO4	6	23	29	440.892
#410	DLX2	6	18	24	660.856
#411	TAL1	6	24	30	274.927
#412	SLC26A3	6	21	27	1576.879
#413	TP73	6	21	27	1376.09
#414	HLF	6	25	31	656.391
#415	RFXAP	6	24	30	1529.925
#416	FOXP2	6	20	26	211.453
#417	SOX11	6	30	36	1177.636
#418	TEF	6	22	28	968.241
#419	TBX22	6	21	27	733.015
#420	ALS2CR8	6	19	25	1509.87
#421	LHX2	6	20	26	1753.58
#422	SIX2	6	25	31	2350.314
#423	LHX9	6	22	28	596.849
#424	THRB	6	28	34	1334.44
#425	SOX18	6	22	28	491.08
#426	MEOX2	6	27	33	1277.007
#427	ISX	6	14	20	349.142
#428	AR	6	17	23	729.937
#429	HOXA4	6	21	27	405.807
#430	POU3F4	6	18	24	331.145
#431	HOPX	6	29	35	1192.17
#432	RORA	6	23	29	473.62
#433	HMGA2	6	23	29	571.316
#434	PPARG	6	26	32	544.284
#435	SIM1	6	24	30	1775.083
#436	MSX1	5	21	26	353.052
#437	RORB	5	27	32	907.031
#438	CREB5	5	30	35	784.161
#439	EBF1	5	26	31	896.566
#440	ZNF80	5	23	28	489.921
#441	FOXL2	5	17	22	303.342
#442	BCL11B	5	24	29	628.391
#443	ZNF24	5	29	34	641.17
#444	PKNOX1	5	23	28	451.262
#445	HOXA13	5	25	30	212.396
#446	TBX20	5	20	25	774.196
#447	TFEC	5	27	32	2189.894
#448	ESRRB	5	27	32	647.309
#449	ZNF483	5	24	29	657.396
#450	HNRNPAB	5	22	27	487.057
#451	MYCN	5	19	24	698.075
#452	BNC1	5	21	26	391.292
#453	NFIB	5	37	42	511.582
#454	BARX1	5	24	29	354.5
#455	FOXI1	5	24	29	352.729
#456	PGR	5	18	23	364.113
#457	ZNF277	5	27	32	1435.302
#458	HIRA	5	20	25	565.397
#459	PPARD	5	21	26	857.513
#460	STRN3	5	23	28	375.639
#461	SP140	4	21	25	373.318
#462	ZNF496	4	29	33	599.594
#463	RCAN1	4	18	22	519.052
#464	ETV1	4	20	24	146.103
#465	CUX2	4	24	28	582.643
#466	PTH	4	26	30	545.677
#467	FOXB1	4	24	28	607.595
#468	PRDM2	4	22	26	320.113
#469	HOXB9	4	27	31	713.547
#470	LMX1A	4	22	26	575.89
#471	SMAD3	4	29	33	450.017
#472	FLI1	4	19	23	335.46
#473	ESX1	4	29	33	757.991
#474	ZIC5	4	17	21	176.919
#475	ANKRD30A	4	26	30	1327.399
#476	RUNX1T1	4	22	26	346.467
#477	HOXD3	4	28	32	472.897
#478	TADA3	4	24	28	458.189
#479	IKZF4	3	16	19	48.386
#480	MGA	3	28	31	249.153
#481	NFYC	3	24	27	238.019
#482	FOXP3	3	30	33	242.992
#483	HOXA9	3	11	14	213.072
#484	VTN	3	27	30	236.941
#485	CRX	3	31	34	588.76
#486	FOSL2	3	24	27	368.221
#487	ETV5	3	27	30	494.29
#488	KLF11	3	15	18	875.656
#489	ZSCAN4	3	22	25	259.645
#490	ETV7	3	22	25	330.819
#491	MYT1L	2	27	29	297.831
#492	LZTS1	2	24	26	267.775
#493	DLX1	2	21	23	177.113
#494	NRL	2	18	20	72.828
#495	ZNF167	2	27	29	172.309
#496	SIX3	2	26	28	207.822
#497	ZFP42	2	22	24	314.642
#498	NR5A2	2	28	30	243.222
#499	SCML1	2	30	32	274.904
#500	ZFHX2	1	22	23	87.929