Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	PTTG1	46	0	46	0
#2	FOXA1	44	4	48	786.107
#3	STAT4	41	4	45	3289.995
#4	KLF7	39	2	41	231.014
#5	SPDEF	39	4	43	401.895
#6	HMGB2	36	2	38	182.161
#7	NEUROD2	34	0	34	0
#8	TRIM28	33	4	37	291.465
#9	UBN1	32	10	42	2808.505
#10	PBX1	32	9	41	2637.102
#11	NKX3-1	30	4	34	203.59
#12	BCL6	29	11	40	2663.735
#13	KLF4	29	5	34	977.723
#14	MLX	28	5	33	1194.751
#15	POU4F2	27	7	34	1518.955
#16	MAFF	27	10	37	1246.209
#17	HCLS1	26	7	33	1100.332
#18	FOXM1	26	3	29	1896.291
#19	JUN	25	7	32	1945.28
#20	SCAND1	25	9	34	2931.037
#21	MSRB2	25	7	32	2044.695
#22	XBP1	24	13	37	1553.496
#23	TCF3	24	8	32	2140.747
#24	MEF2A	24	8	32	498.629
#25	SP4	23	9	32	1485.738
#26	TFAP2C	23	8	31	1036.29
#27	LASS2	23	6	29	716.247
#28	AATF	22	7	29	1121.207
#29	SPIB	22	6	28	1927.817
#30	CUX2	22	9	31	1414.831
#31	HMGA2	22	7	29	2460.22
#32	EGR1	22	2	24	236.918
#33	CREB3	21	10	31	3105.374
#34	MAFG	21	10	31	1588.403
#35	ZNF394	21	5	26	690.368
#36	GTF2IRD1	21	10	31	3735.115
#37	TARDBP	21	8	29	1703.697
#38	CTBP1	21	13	34	3245.045
#39	CREB3L1	20	8	28	1523.003
#40	E2F4	20	5	25	1382.36
#41	KLF10	20	11	31	3433.87
#42	MEIS2	20	7	27	965.199
#43	TFDP2	19	15	34	6470.388
#44	NR2F6	19	9	28	1460.138
#45	HES1	19	9	28	628.649
#46	RUNX1	19	14	33	3199.4
#47	TGIF1	19	8	27	1451.397
#48	TCF7	19	3	22	100.951
#49	SOX9	19	6	25	648.666
#50	NR2F2	19	15	34	2859.585
#51	FOXF1	19	8	27	956.086
#52	TCF4	19	11	30	2581.968
#53	GTF2H3	19	11	30	2018.489
#54	TAL1	18	5	23	100.942
#55	LHX3	18	7	25	1517.227
#56	ADNP	18	7	25	328.692
#57	HMBOX1	18	10	28	4157.087
#58	FOXN2	18	7	25	694.398
#59	CBFA2T3	18	9	27	1229.932
#60	KLF1	18	5	23	658.409
#61	DRAP1	18	8	26	587.599
#62	GCFC1	18	9	27	2067.386
#63	TADA3	18	5	23	309.564
#64	ZFHX4	17	7	24	476.923
#65	HNRNPAB	17	12	29	2419.622
#66	TFCP2L1	17	9	26	1039.152
#67	SUPT4H1	17	11	28	876.002
#68	NFIB	17	9	26	409.581
#69	HDAC1	17	5	22	417.383
#70	MBD1	17	10	27	2770.401
#71	BCL11B	17	12	29	3008.234
#72	EDF1	17	8	25	885.973
#73	RERE	17	9	26	1495.336
#74	ZNF131	16	15	31	3767.527
#75	NR2F1	16	6	22	854.836
#76	RUNX1T1	16	14	30	6416.447
#77	KLF9	16	10	26	1228.415
#78	ZFP36L2	16	12	28	1648.033
#79	CEBPB	16	6	22	1170.031
#80	ZNF24	16	6	22	733.478
#81	IRF9	16	10	26	1575.269
#82	TFCP2	16	12	28	1284.945
#83	MEIS1	16	13	29	3686.825
#84	IRF6	16	6	22	880.587
#85	LEF1	16	10	26	800.296
#86	E4F1	16	9	25	2060.261
#87	HOXD1	15	8	23	2900.037
#88	FOXF2	15	7	22	1891.98
#89	TFE3	15	13	28	2320.041
#90	OLIG2	15	8	23	876.543
#91	ERG	15	14	29	3808.666
#92	TRIM22	15	11	26	2268.134
#93	BACH1	15	9	24	1383.413
#94	VDR	15	9	24	828.712
#95	RBPJ	15	8	23	2982.571
#96	CLOCK	15	9	24	737.255
#97	STAT5A	15	12	27	4067.786
#98	NFE2L1	15	8	23	535.835
#99	HOXA10	15	14	29	1033.727
#100	SNAI2	15	12	27	2112.526
#101	TFEC	15	8	23	1374.592
#102	NR5A2	15	10	25	2776.207
#103	CNOT7	14	6	20	985.121
#104	ZNF148	14	7	21	1312.729
#105	CEBPD	14	13	27	2344.991
#106	KLF2	14	7	21	614.727
#107	STAT6	14	17	31	4040.669
#108	MYT1	14	10	24	2322.575
#109	ZNF189	14	6	20	1460.757
#110	TSC22D1	14	12	26	1861.949
#111	LASS6	14	8	22	727.642
#112	ZNF91	14	10	24	1266.944
#113	GATAD2A	14	9	23	1668.612
#114	FOXC1	14	10	24	2149.436
#115	ZNF238	14	8	22	1621.422
#116	EHF	14	9	23	1368.712
#117	HAND1	14	8	22	613.942
#118	CREBL2	14	12	26	2406.603
#119	NR4A1	14	7	21	1103.435
#120	REXO4	14	8	22	1354.791
#121	ZBTB38	14	9	23	1143.18
#122	REL	14	7	21	1061.423
#123	BHLHE40	14	8	22	683.4
#124	NOLC1	14	11	25	1187.093
#125	HNF1B	14	11	25	5598.285
#126	IRF1	14	9	23	1503.537
#127	NFATC3	13	12	25	2227.324
#128	ZNF117	13	10	23	1162.308
#129	SOX11	13	7	20	845.892
#130	HCFC1	13	10	23	3202.431
#131	TFDP1	13	6	19	154.239
#132	TCF21	13	6	19	513.658
#133	RFX5	13	7	20	3223.08
#134	TRIM29	13	4	17	245.917
#135	GRHL2	13	4	17	352.334
#136	MTA1	13	8	21	888.62
#137	SATB1	13	14	27	4338.462
#138	GATA3	13	10	23	1982.633
#139	HHEX	13	10	23	1247.117
#140	TCF25	13	13	26	1952.015
#141	ELF3	13	8	21	2923.404
#142	SREBF2	13	10	23	3128.203
#143	FOSB	13	3	16	146.938
#144	EGR3	13	10	23	1348.25
#145	AR	13	15	28	1533.127
#146	TEF	12	12	24	3097.533
#147	ZNF83	12	11	23	2022.61
#148	NR3C2	12	8	20	1654.965
#149	YBX1	12	12	24	1911.638
#150	NFYA	12	11	23	2497.43
#151	MITF	12	7	19	1183.082
#152	NFAT5	12	11	23	2752.709
#153	HOXB5	12	8	20	576.011
#154	ETS2	12	12	24	2516.922
#155	KLF6	12	14	26	1283.038
#156	FOS	12	3	15	248.67
#157	PHF1	12	15	27	1397.059
#158	ZNF3	12	9	21	1282.574
#159	HOXB13	12	14	26	1404.637
#160	ECSIT	12	10	22	452.082
#161	TULP4	12	8	20	1771.767
#162	GATA2	12	10	22	809.709
#163	KLF15	11	11	22	566.548
#164	NFIC	11	13	24	1539.691
#165	SATB2	11	11	22	998.891
#166	MLL	11	11	22	1391.116
#167	ATF3	11	11	22	495.223
#168	POU4F1	11	6	17	1412.787
#169	TBP	11	12	23	1135.4
#170	ISL1	11	11	22	2603.877
#171	EGR2	11	6	17	667.866
#172	AHR	11	14	25	2415.637
#173	CBFA2T2	11	6	17	198.085
#174	TFAP2A	11	13	24	1727.693
#175	RFXANK	11	14	25	1544.759
#176	AFF1	11	11	22	2125.796
#177	HOXA7	11	11	22	1913.361
#178	BCL3	11	15	26	2112.63
#179	HOXC10	11	8	19	1439.668
#180	TAF4	11	6	17	683.153
#181	TSC22D2	11	12	23	4430.204
#182	HOXD3	11	9	20	1913.365
#183	TAF12	10	13	23	1447.482
#184	IRF7	10	7	17	2424.625
#185	E2F3	10	13	23	1083.047
#186	HOXA9	10	8	18	3290.831
#187	IRF2	10	12	22	3306.127
#188	FOXE1	10	9	19	1275.135
#189	ZNF444	10	8	18	662.848
#190	SPEN	10	17	27	1155.688
#191	NCOR1	10	8	18	2851.706
#192	NFYB	10	9	19	706.715
#193	E2F8	10	11	21	2009.094
#194	IRF4	10	11	21	2850.535
#195	ZNF217	10	12	22	960.89
#196	PPARD	10	7	17	676.612
#197	JUNB	10	7	17	1579.001
#198	ALX3	10	11	21	1189.254
#199	PRRX1	10	5	15	530.595
#200	TBX3	10	15	25	1035.284
#201	TBX2	10	11	21	1402.017
#202	HINFP	10	13	23	2110.17
#203	PLSCR1	9	11	20	681.155
#204	NFE2	9	3	12	272.034
#205	IRX4	9	9	18	817.564
#206	MECOM	9	16	25	3792.55
#207	MAFB	9	10	19	1315.334
#208	HDAC2	9	9	18	679.12
#209	HOXA11	9	11	20	1712.929
#210	SNAPC4	9	11	20	1694.659
#211	IRF8	9	9	18	480.989
#212	RORC	9	10	19	1283.752
#213	FOXO3	9	9	18	1698.039
#214	NR3C1	9	13	22	1102.269
#215	ZNF323	9	9	18	982.155
#216	TGIF2	9	9	18	666.123
#217	RUNX2	9	11	20	1010.866
#218	NFKB2	9	8	17	1702.3
#219	LZTS1	9	7	16	738.131
#220	ZHX2	9	7	16	700.586
#221	ETS1	9	10	19	1901.074
#222	SMAD2	9	6	15	374.445
#223	SOX21	9	8	17	1437.98
#224	ZNF140	9	13	22	1258.836
#225	JUND	9	8	17	1147.781
#226	OVOL1	9	7	16	1662.907
#227	EN2	9	6	15	1925.957
#228	ZSCAN16	9	8	17	686.624
#229	SNAPC2	9	9	18	801.31
#230	PBX3	9	11	20	1517.338
#231	ZNF192	9	13	22	2444.311
#232	ARID4A	8	7	15	1030.29
#233	ELK3	8	10	18	1067.171
#234	SMAD3	8	9	17	1135.021
#235	GATA1	8	6	14	442.429
#236	CREB1	8	12	20	1302.69
#237	ZNF75D	8	14	22	1571.371
#238	ESR1	8	11	19	1107.204
#239	PPARG	8	10	18	1363.874
#240	TAF1B	8	12	20	797.668
#241	BACH2	8	6	14	818.653
#242	STAT1	8	11	19	1224.023
#243	TP53	8	8	16	1745.366
#244	SOX4	8	15	23	1712.965
#245	TCF7L2	8	10	18	890.816
#246	SP140	8	9	17	727.948
#247	SCML1	8	9	17	950.176
#248	E2F6	8	5	13	159.231
#249	CITED2	8	9	17	1353.073
#250	THRB	8	9	17	1751.977
#251	MTF1	8	9	17	733.816
#252	NR1D2	8	12	20	1805.492
#253	EVX1	8	13	21	1117.27
#254	ZNF232	8	11	19	1025.748
#255	EGR4	8	14	22	2750.044
#256	TEAD3	8	10	18	1072.084
#257	IRF3	8	8	16	1577.703
#258	HOXB7	8	10	18	903.132
#259	ATF6B	8	11	19	1830.778
#260	BHLHE41	7	15	22	2797.361
#261	TCFL5	7	8	15	690.489
#262	PAX3	7	11	18	1496.412
#263	FLI1	7	9	16	476.11
#264	NR4A3	7	14	21	1538.172
#265	ZNF215	7	7	14	2180.24
#266	HOXB9	7	11	18	1919.834
#267	HMG20A	7	12	19	1588.281
#268	ZKSCAN1	7	11	18	2385.945
#269	ENO1	7	5	12	767.436
#270	KLF11	7	11	18	1450.437
#271	SLC26A3	7	10	17	1238.441
#272	SIM2	7	13	20	2918.412
#273	RELB	7	12	19	1466.821
#274	WNT5A	7	10	17	1482.9
#275	NR1I3	7	6	13	245.499
#276	SLC2A4RG	7	11	18	1100.733
#277	TBX19	7	10	17	871.411
#278	HMG20B	7	13	20	1145.799
#279	HIF3A	7	10	17	1230.812
#280	NFATC4	7	8	15	1189.881
#281	PAX5	7	10	17	904.04
#282	MSX1	7	3	10	514.938
#283	TSC22D3	7	8	15	418.142
#284	MGA	7	7	14	896.955
#285	YEATS4	7	12	19	575.144
#286	RXRA	7	11	18	1296.308
#287	E2F5	7	10	17	1209.485
#288	PRDM2	7	8	15	449.436
#289	GLI2	7	9	16	738.313
#290	AEBP1	7	10	17	1355.704
#291	TCF12	7	12	19	1479.716
#292	ELF1	7	11	18	2082.584
#293	ELF4	7	11	18	622.711
#294	CREBZF	7	13	20	838.504
#295	TAF5	7	10	17	1299.712
#296	ONECUT1	7	10	17	710.594
#297	TAF6	7	8	15	920.855
#298	ARNT2	7	14	21	1124.362
#299	RARB	7	10	17	866.21
#300	PCGF2	7	13	20	1816.683
#301	NPAS2	7	15	22	1867.361
#302	NR4A2	7	8	15	351.581
#303	ZNF268	7	11	18	1863.521
#304	MYC	7	11	18	866.086
#305	ATF6	6	11	17	1046.329
#306	HOXD11	6	11	17	558.871
#307	LHX2	6	12	18	1874.685
#308	SMAD5	6	11	17	370.314
#309	FUBP1	6	10	16	2433.444
#310	NFATC1	6	12	18	2072.982
#311	ERF	6	9	15	446.861
#312	KLF5	6	14	20	1086.971
#313	MLLT10	6	10	16	1943.069
#314	MEIS3P1	6	11	17	363.011
#315	TP63	6	11	17	2475.625
#316	CUX1	6	13	19	1077.536
#317	ZNF277	6	12	18	860.109
#318	ZSCAN12	6	12	18	746.839
#319	FOXN3	6	11	17	941.815
#320	NFIL3	6	8	14	633.965
#321	E2F1	6	9	15	1193.022
#322	RARA	6	12	18	649.781
#323	DLX2	6	9	15	1148.885
#324	ADNP2	6	9	15	1412.507
#325	DBP	6	13	19	1213.511
#326	SRF	6	11	17	688.347
#327	SOX5	6	7	13	710.486
#328	HIRA	6	10	16	729.168
#329	CNOT8	6	10	16	1210.136
#330	SUPT6H	6	14	20	1224.279
#331	CBFB	6	7	13	458.114
#332	HOXC4	6	12	18	996.426
#333	BTG2	6	11	17	936.64
#334	SOX17	6	10	16	670.075
#335	HOXB2	6	14	20	1168.938
#336	SIX2	6	13	19	1935.349
#337	RXRG	6	10	16	1176.747
#338	ATF5	6	9	15	1338.899
#339	ZNF187	6	9	15	1073.787
#340	ZBTB25	6	10	16	1065.416
#341	NOTCH1	6	12	18	1291.578
#342	RUNX3	5	14	19	403.383
#343	TRPS1	5	10	15	2070.291
#344	CSDA	5	9	14	1145.349
#345	HMGA1	5	8	13	877.377
#346	KLF12	5	7	12	662.656
#347	TBR1	5	12	17	499.285
#348	PKNOX1	5	12	17	643.694
#349	STAT5B	5	9	14	435.508
#350	FOXG1	5	8	13	414.308
#351	VENTX	5	11	16	1898.595
#352	ZNF132	5	14	19	820.036
#353	IRF5	5	12	17	270.07
#354	PURA	5	10	15	960.622
#355	IKZF1	5	5	10	791.196
#356	PFDN1	5	10	15	473.492
#357	RBPJL	5	10	15	952.472
#358	MSL3	5	11	16	808.97
#359	GTF2H4	5	11	16	903.729
#360	RCAN1	5	10	15	1070.485
#361	ZNF167	5	10	15	465.996
#362	ETV4	5	13	18	1407.612
#363	HOXB6	5	4	9	344.783
#364	GAS7	5	15	20	1198.697
#365	RELA	5	10	15	1447.28
#366	TFAM	5	13	18	1107.695
#367	NR2C1	5	8	13	2140.876
#368	VAX2	5	9	14	1068.452
#369	NKX2-5	5	9	14	1066.847
#370	HMGB1	5	10	15	1321.701
#371	ASCL1	5	6	11	456.968
#372	ZNF219	5	11	16	829.627
#373	USF2	5	11	16	769.539
#374	TFAP4	5	12	17	840.404
#375	SMAD1	5	13	18	376.25
#376	AFF4	5	9	14	888.405
#377	PBX2	5	9	14	1361.421
#378	ARNTL2	5	12	17	1626.001
#379	RARG	5	12	17	1583.52
#380	POU5F1B	5	14	19	1513.869
#381	CDKN2A	4	9	13	490.372
#382	ZNF93	4	14	18	517.193
#383	GATAD1	4	10	14	436.603
#384	TFEB	4	12	16	423.747
#385	CEBPE	4	14	18	754.603
#386	NR2E3	4	12	16	758.866
#387	HOXA5	4	8	12	877.237
#388	ZNF135	4	14	18	560.359
#389	ZIC3	4	8	12	903.157
#390	BATF	4	8	12	852.089
#391	ONECUT2	4	10	14	1564.123
#392	ZNF174	4	9	13	768.079
#393	EPAS1	4	9	13	379.173
#394	HLF	4	12	16	1059.666
#395	HOXD4	4	11	15	1053.466
#396	ESRRA	4	9	13	544.39
#397	HR	4	13	17	768.742
#398	HNF4A	4	10	14	445.244
#399	HOXA4	4	9	13	2259.442
#400	MYCL1	4	13	17	1674.373
#401	ZFP36L1	4	10	14	850.26
#402	SIX1	4	9	13	658.644
#403	POU3F4	4	9	13	661.2
#404	HOXA3	4	7	11	497.667
#405	TBX10	4	8	12	757.131
#406	ZNF202	4	12	16	591.664
#407	MAX	4	11	15	1154.796
#408	MNX1	4	13	17	805.726
#409	TBX1	4	8	12	374.663
#410	FOXO1	4	16	20	440.979
#411	KLF3	4	9	13	1161.914
#412	HNF1A	4	12	16	2111.122
#413	T	4	8	12	1044.125
#414	ELK4	3	8	11	446.128
#415	BNC1	3	12	15	1380.831
#416	NFE2L3	3	9	12	527.175
#417	TSHZ2	3	14	17	515.217
#418	MEF2C	3	15	18	634.009
#419	ETV1	3	12	15	618.449
#420	FOXA2	3	8	11	142.747
#421	HOXC8	3	6	9	1058.671
#422	ZSCAN18	3	13	16	985.417
#423	MZF1	3	9	12	694.707
#424	TBX5	3	8	11	172.039
#425	CITED1	3	12	15	696.922
#426	RFX3	3	10	13	698.694
#427	ZNF134	3	11	14	858.635
#428	MSX2	3	13	16	1173.522
#429	CREM	3	11	14	1319.814
#430	NFIX	3	9	12	218.663
#431	TSC22D4	3	8	11	460.946
#432	ESR2	3	8	11	601.036
#433	SREBF1	3	10	13	258.779
#434	ZXDC	3	12	15	851.804
#435	NFYC	3	10	13	999.138
#436	TWIST1	3	16	19	1104.269
#437	FOXD1	3	10	13	496.054
#438	ELF5	3	12	15	860.807
#439	ZGPAT	3	12	15	379.877
#440	ZNF446	3	9	12	472.212
#441	FEV	3	7	10	409.748
#442	ZNF175	3	13	16	464.244
#443	MMP14	3	7	10	838.061
#444	MYF6	3	8	11	243.851
#445	SOLH	3	8	11	178.937
#446	ESRRG	3	13	16	205.466
#447	TRIM25	3	9	12	388.886
#448	EMX1	3	12	15	1005.418
#449	NPAT	2	6	8	854.224
#450	ZNF287	2	12	14	311.68
#451	MEF2D	2	5	7	290.488
#452	GABPB1	2	8	10	102.97
#453	RORA	2	10	12	876.985
#454	ZIC1	2	8	10	255.673
#455	ZNF500	2	9	11	721.629
#456	ZEB1	2	10	12	334.759
#457	CEBPA	2	10	12	329.426
#458	NR5A1	2	8	10	589.091
#459	ELK1	2	6	8	71.608
#460	ZNF639	2	9	11	143.05
#461	SOX2	2	8	10	77.156
#462	NR0B1	2	10	12	1621.137
#463	HMX1	2	12	14	254.265
#464	HOXD13	2	8	10	331.642
#465	STAT3	2	17	19	1334.131
#466	SIM1	2	13	15	872.141
#467	MSC	2	11	13	201.503
#468	ZNF236	2	9	11	195.201
#469	KDM5A	2	7	9	185.498
#470	HOPX	2	15	17	1548.719
#471	PAX8	2	12	14	582.11
#472	LHX6	2	10	12	153.899
#473	ZNF35	2	7	9	381.056
#474	IRX5	2	10	12	687.312
#475	NKX2-1	2	6	8	549.854
#476	GATA6	2	9	11	185.052
#477	GLI3	2	9	11	1136.844
#478	ARNTL	2	12	14	570.148
#479	HOXB1	2	13	15	997.944
#480	ETV5	2	11	13	603.931
#481	MYBL2	1	9	10	184.726
#482	HOXD9	1	9	10	259.815
#483	PKNOX2	1	10	11	589.129
#484	CBL	1	7	8	52.897
#485	TEAD4	1	12	13	313.38
#486	VTN	1	14	15	56.472
#487	ZNF154	1	10	11	84.179
#488	ZNF434	1	9	10	86.363
#489	NR6A1	1	7	8	121.046
#490	HEY1	1	14	15	452.231
#491	PHOX2B	1	9	10	73.438
#492	C2orf3	1	8	9	1110.53
#493	SCAND2	1	11	12	166.482
#494	THRA	0	7	7	0
#495	NR1I2	0	8	8	0
#496	MAF	0	14	14	0
#497	ZHX3	0	16	16	0
#498	PPARA	0	13	13	0
#499	POU2F2	0	12	12	0
#500	BATF3	0	13	13	0