Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	RORA	43	7	50	1399.664
#2	ZEB2	42	2	44	89.231
#3	ETS1	39	3	42	187.892
#4	UHRF1	37	6	43	1537.183
#5	TBX5	33	3	36	100.266
#6	FOXN3	32	5	37	142.592
#7	MEF2D	32	12	44	716.45
#8	CSRNP1	32	4	36	146.066
#9	TCF21	30	6	36	1093.862
#10	EBF1	28	6	34	1503.37
#11	MTA3	28	9	37	240.096
#12	FOXO3	27	7	34	5261.35
#13	TBX3	26	3	29	1489.367
#14	KLF6	26	5	31	114.359
#15	LCOR	26	8	34	1060.53
#16	ZNF438	25	9	34	2401.095
#17	TSHZ3	25	7	32	313.583
#18	KLF12	24	6	30	134.863
#19	TCF4	24	2	26	117.685
#20	ZNF70	24	12	36	2693.844
#21	NFXL1	24	9	33	1737.36
#22	NFAT5	24	5	29	1800.453
#23	YY1	23	12	35	2236.256
#24	SOX7	23	7	30	103.339
#25	PGR	22	7	29	645.522
#26	SIX4	22	7	29	546.181
#27	ZBTB38	22	8	30	1886.917
#28	RELA	22	3	25	723.692
#29	ZNF92	22	10	32	675.817
#30	ZNF367	21	5	26	1367.127
#31	BACH1	21	5	26	938.518
#32	FOXP4	21	11	32	842.961
#33	ZNF281	20	14	34	1307.856
#34	GSX1	20	10	30	1598.25
#35	NFIX	19	9	28	7814.459
#36	HEYL	19	7	26	1213.11
#37	NR6A1	19	8	27	1742.627
#38	TFDP1	19	11	30	2480.319
#39	SOX6	19	10	29	2031.369
#40	NR2F2	19	5	24	2547.573
#41	HES6	19	9	28	2410.448
#42	ZEB1	18	5	23	732.957
#43	LMX1A	18	5	23	329.902
#44	ZNF496	18	9	27	1665.996
#45	ZSCAN21	18	5	23	778.195
#46	CBFA2T2	18	10	28	599.908
#47	ZC3H8	18	12	30	1153.103
#48	SMAD9	18	16	34	2264.724
#49	CNBP	18	10	28	287.308
#50	SIX1	17	9	26	341.702
#51	ERG	17	11	28	983.093
#52	CBL	17	6	23	874.245
#53	ZFHX3	17	9	26	1152.285
#54	FOXO6	17	14	31	1812.805
#55	ARNTL2	17	11	28	2597.397
#56	SCAND1	17	12	29	1318.39
#57	ZNF138	17	6	23	2290.381
#58	JDP2	16	13	29	443.722
#59	KDM5A	16	9	25	1491.95
#60	TCF19	16	8	24	1940.901
#61	HNF4A	16	10	26	1368.916
#62	HMGB1	16	8	24	674.658
#63	TAF10	16	8	24	833.22
#64	EHF	16	14	30	1147.487
#65	MGA	16	5	21	1257.964
#66	THRB	16	7	23	753.414
#67	CREB3L4	16	12	28	1438.576
#68	ZFP42	15	4	19	670.993
#69	PRDM1	15	9	24	1201.674
#70	MYT1L	15	7	22	785.907
#71	SMAD4	15	11	26	1185.203
#72	FOSL2	15	15	30	677.367
#73	TAF4B	15	14	29	1715.991
#74	NR2C2	15	10	25	1610.179
#75	ZNF397	15	7	22	752.162
#76	E2F2	15	8	23	1011.231
#77	ZNF268	15	6	21	358.551
#78	ZNF148	15	9	24	809.468
#79	MITF	15	11	26	915.088
#80	GRHL3	15	9	24	1209.504
#81	SLC2A4RG	14	12	26	1663.855
#82	C5orf41	14	13	27	1419.252
#83	TFAP2D	14	14	28	4023.283
#84	CREM	14	5	19	1019.71
#85	SIX5	14	8	22	1223.745
#86	ZNF81	14	12	26	907.654
#87	GABPA	14	8	22	517.981
#88	GLI3	14	13	27	4345.024
#89	NFIC	14	9	23	1463.71
#90	ZFP90	14	13	27	1805.818
#91	HOXB13	14	10	24	1169.254
#92	ZHX1	14	12	26	2391.782
#93	IRF1	14	9	23	165.37
#94	MESP1	14	13	27	1861.482
#95	SOX5	13	9	22	821.455
#96	TSC22D3	13	9	22	757.834
#97	IRX2	13	20	33	1762.726
#98	PRRX1	13	11	24	1337.593
#99	NFIA	13	11	24	768.957
#100	ELF2	13	8	21	1150.129
#101	PGBD1	13	9	22	1484.546
#102	FOXK2	13	15	28	1645.406
#103	ANKRD30A	13	6	19	717.676
#104	ARID4A	13	13	26	1926.816
#105	POU6F1	13	9	22	1064.973
#106	IKZF1	13	9	22	195.924
#107	ETV5	13	8	21	1361.631
#108	TEAD2	13	13	26	2552.55
#109	FBXW7	13	10	23	1304.253
#110	LASS6	13	13	26	691.943
#111	HOXB3	13	14	27	4383.748
#112	CREB1	12	11	23	1072.669
#113	KLF9	12	11	23	278.765
#114	TCF7L2	12	4	16	565.176
#115	ETS2	12	11	23	934.625
#116	KLF2	12	8	20	91.999
#117	HOXB4	12	12	24	2020.416
#118	RFXAP	12	9	21	828.819
#119	TARDBP	12	15	27	1510.571
#120	NFATC2	12	14	26	911.992
#121	SMAD5	12	14	26	1524.685
#122	ETV6	12	12	24	1452.173
#123	TSHZ1	12	6	18	818.264
#124	HOXA2	12	12	24	1186.228
#125	HOXA3	11	10	21	298.788
#126	ZNF639	11	14	25	1333.34
#127	ZNF193	11	7	18	540.642
#128	DMRT2	11	7	18	560.71
#129	GSX2	11	10	21	1360.395
#130	DLX1	11	10	21	1383.052
#131	KLF17	11	7	18	642.179
#132	HES5	11	5	16	335.504
#133	RORC	11	16	27	1436.428
#134	CREBZF	11	8	19	994.286
#135	HIC1	11	7	18	297.244
#136	TFCP2	11	10	21	1686.53
#137	MBD1	11	7	18	1142.717
#138	HOXB8	11	3	14	242.328
#139	LASS5	11	9	20	917.377
#140	MLX	11	10	21	1018.9
#141	ZNF24	11	12	23	1089.253
#142	ZNF117	11	18	29	1845.259
#143	ZNF213	11	7	18	207.172
#144	PAX6	11	5	16	1306.985
#145	FOXN2	11	12	23	970.733
#146	FOXD3	11	7	18	832.212
#147	FOXR1	11	12	23	1460.399
#148	MIXL1	10	9	19	767.721
#149	SREBF2	10	11	21	848.439
#150	STAT2	10	10	20	750.198
#151	TBX15	10	12	22	727.107
#152	TFEC	10	5	15	292.406
#153	TCF20	10	8	18	1251.414
#154	CREB3L3	10	8	18	1243.822
#155	E2F7	10	12	22	3014.633
#156	ZNF449	10	10	20	1125.754
#157	FOXA1	10	17	27	1222.668
#158	FOXK1	10	12	22	1435.179
#159	GATAD2A	10	10	20	1206.133
#160	HNF4G	10	14	24	1300.234
#161	HOXA13	10	8	18	1393.979
#162	AHCTF1	10	15	25	1082.434
#163	ISX	10	11	21	1355.047
#164	KLF15	10	11	21	449.52
#165	ZNF19	10	12	22	878.277
#166	ZKSCAN2	10	3	13	508.247
#167	MYPOP	10	11	21	942.531
#168	NR1D2	10	16	26	1686.173
#169	BCL11B	10	7	17	310.862
#170	PAX3	10	8	18	605.36
#171	VSX1	10	6	16	1054.243
#172	PEG3	10	7	17	166.425
#173	BCL6	10	13	23	1191.259
#174	TULP4	10	11	21	877.878
#175	TRIM25	10	15	25	1584.687
#176	SLC30A9	10	11	21	826.402
#177	SOX1	10	7	17	654.284
#178	SOX2	10	15	25	995.907
#179	TCF3	9	7	16	515.001
#180	ZFHX4	9	5	14	354.99
#181	EPAS1	9	9	18	798.796
#182	CTBP1	9	8	17	697.993
#183	SP3	9	11	20	200.069
#184	CTNNB1	9	10	19	780.646
#185	GATA5	9	7	16	377.841
#186	FOXN4	9	6	15	564.421
#187	CNOT7	9	11	20	1142.458
#188	MLLT10	9	13	22	316.974
#189	BRD8	9	10	19	932.609
#190	ZGLP1	9	10	19	1352.267
#191	AFF4	9	11	20	997.04
#192	MSX1	9	9	18	828.961
#193	ZSCAN22	9	10	19	933.979
#194	SOX17	9	10	19	371.077
#195	ZNF274	9	9	18	921.085
#196	GLI2	9	11	20	564.824
#197	RBPJ	9	6	15	1325.466
#198	PCGF2	9	12	21	1156.832
#199	HMGB2	9	10	19	1063.87
#200	NR1H4	8	8	16	888.319
#201	FOXS1	8	9	17	1940.185
#202	ZIC2	8	13	21	1887.879
#203	ZNF37A	8	12	20	1046.618
#204	HOXC9	8	13	21	1097.098
#205	CSRNP3	8	11	19	2209.137
#206	HOXB9	8	7	15	702.959
#207	IKZF4	8	12	20	1067.641
#208	PBX3	8	10	18	577.742
#209	SP4	8	18	26	1865.505
#210	HSF5	8	12	20	1393.109
#211	FOXH1	8	3	11	244.989
#212	MEIS3	8	6	14	523.253
#213	ATF6	8	13	21	1515.892
#214	MEF2A	8	9	17	279.937
#215	TEF	8	10	18	1421.797
#216	KLF16	8	10	18	717.092
#217	RUNX2	8	14	22	1597.238
#218	EVX1	8	8	16	821.488
#219	KLF3	8	12	20	873.472
#220	PURB	8	16	24	1979.761
#221	ZNF628	8	9	17	593.134
#222	EGR1	8	12	20	1045.523
#223	NFIB	8	13	21	994.328
#224	CRX	8	6	14	503.593
#225	ATF5	8	11	19	1190.011
#226	NFYB	8	7	15	183.131
#227	STAT3	8	13	21	786.64
#228	GATAD2B	8	12	20	585.293
#229	NOBOX	8	9	17	548.699
#230	ZNF33A	8	9	17	727.516
#231	ZNF207	7	16	23	788.308
#232	MTF1	7	10	17	497.623
#233	ASCL2	7	9	16	499.041
#234	HOMEZ	7	11	18	1175.115
#235	HIF3A	7	12	19	619.816
#236	HEY2	7	10	17	919.047
#237	HCFC1	7	9	16	1039.167
#238	FOXQ1	7	15	22	2037.146
#239	ONECUT2	7	5	12	404.749
#240	ZXDC	7	9	16	762.534
#241	SOX12	7	3	10	80.293
#242	OVOL1	7	8	15	630.277
#243	ZNF394	7	10	17	689.423
#244	USF1	7	10	17	777.543
#245	TGIF2LY	7	9	16	698.769
#246	BHLHE41	7	14	21	2538.908
#247	FOXC2	7	9	16	440.266
#248	POU3F2	7	17	24	1989.007
#249	FOXA3	7	9	16	1476.625
#250	PPARA	7	12	19	667.874
#251	ZNF445	7	12	19	857.495
#252	TAF1B	7	7	14	922.426
#253	RCOR2	7	10	17	807.267
#254	SCRT1	7	10	17	597.046
#255	ZSCAN18	7	11	18	771.647
#256	CSDA	7	12	19	801.682
#257	STAT1	7	15	22	999.843
#258	SMAD1	7	18	25	1596.233
#259	SMAD2	7	6	13	1130.69
#260	ZSCAN2	7	14	21	1583.027
#261	CREB3L2	7	10	17	324.862
#262	LMO4	7	12	19	1878.482
#263	ZNF167	7	9	16	2423.856
#264	MAFB	7	11	18	894.171
#265	ZNF197	7	8	15	627.186
#266	PHTF1	6	8	14	504.213
#267	BATF2	6	12	18	796.296
#268	MAF	6	13	19	1312.749
#269	ZFPM1	6	9	15	578.598
#270	HDAC2	6	10	16	695.587
#271	HMX2	6	8	14	646.928
#272	ZNF140	6	15	21	1020.016
#273	ZSCAN29	6	12	18	1053.529
#274	IRX1	6	14	20	1188.748
#275	HNRNPK	6	14	20	937.796
#276	IRX3	6	20	26	4144.805
#277	EGR4	6	8	14	507.205
#278	DLX6	6	10	16	708.046
#279	ZNF71	6	10	16	848.19
#280	PPARD	6	10	16	1045.753
#281	RUNX3	6	8	14	411.451
#282	SALL1	6	4	10	181.272
#283	POU2F2	6	14	20	874.006
#284	TRPS1	6	15	21	758.035
#285	C1orf85	6	9	15	323.756
#286	MEIS1	6	11	17	275.784
#287	SEBOX	6	5	11	357.519
#288	FOXP1	6	12	18	764.991
#289	RFX3	5	9	14	664.234
#290	ARX	5	14	19	564.627
#291	ATF7	5	13	18	1425.073
#292	BARHL1	5	11	16	354.234
#293	CREB5	5	17	22	1270.489
#294	FOXP2	5	16	21	1291.059
#295	GLIS2	5	13	18	722.998
#296	HNRNPAB	5	10	15	1218.245
#297	HOXA7	5	7	12	58.25
#298	HOXD10	5	6	11	639.388
#299	HOXD8	5	13	18	792.152
#300	ISL2	5	11	16	742.969
#301	MXD1	5	22	27	1098.654
#302	NCOR1	5	8	13	270.44
#303	NFE2L3	5	12	17	623.289
#304	NFYC	5	16	21	1647.079
#305	OTX2	5	3	8	124.994
#306	PHF5A	5	12	17	992.465
#307	PLSCR1	5	11	16	435.4
#308	PROX1	5	16	21	999.687
#309	SCML1	5	9	14	576.583
#310	SIN3A	5	13	18	484.064
#311	SOLH	5	7	12	237.444
#312	SP1	5	8	13	711.887
#313	SPIB	5	8	13	416.631
#314	TBX22	5	4	9	204.958
#315	TCFL5	5	6	11	760.636
#316	TFCP2L1	5	15	20	1433.238
#317	ZFP36L2	5	10	15	721.732
#318	ZNF256	5	9	14	271.639
#319	ZNF498	5	9	14	897.918
#320	ZNF83	5	9	14	299.246
#321	ZNF91	5	14	19	697.431
#322	ZSCAN12	5	9	14	1016.336
#323	ADNP	4	15	19	1234.917
#324	CSRNP2	4	7	11	255.583
#325	TBX1	4	6	10	284.507
#326	MLL	4	13	17	495.208
#327	RCOR1	4	9	13	360.386
#328	ARNT	4	15	19	878.367
#329	POU2F1	4	8	12	882.497
#330	MAFK	4	13	17	798.418
#331	TSC22D1	4	11	15	474.553
#332	LHX6	4	12	16	496.401
#333	PBX4	4	11	15	862.127
#334	ZRANB2	4	16	20	910.972
#335	L3MBTL4	4	15	19	725.856
#336	ZXDA	4	12	16	562.715
#337	ZNF3	4	7	11	328.588
#338	HOXD13	4	7	11	475.993
#339	ZBTB17	4	13	17	179.448
#340	ONECUT3	4	8	12	694.535
#341	NR2C1	4	7	11	189.823
#342	NOTCH1	4	10	14	391.228
#343	DMBX1	4	4	8	172.777
#344	ZFHX2	4	11	15	530.757
#345	EOMES	4	8	12	129.336
#346	RORB	4	9	13	325.075
#347	CREBBP	4	11	15	230.813
#348	FLI1	4	9	13	261.418
#349	MYCN	4	14	18	1310.81
#350	FOXP3	4	14	18	798.619
#351	GATA6	4	9	13	546.078
#352	SOX8	3	8	11	868.492
#353	SIX3	3	4	7	210.367
#354	SCAND3	3	8	11	204.583
#355	RFX1	3	9	12	820.438
#356	PCGF6	3	10	13	209.491
#357	NFATC4	3	9	12	667.704
#358	MSRB2	3	9	12	472.832
#359	ZIC1	3	7	10	323.813
#360	MNT	3	4	7	176.532
#361	MKX	3	9	12	235.714
#362	ZNF131	3	16	19	409.338
#363	MECOM	3	18	21	907.211
#364	MAFG	3	13	16	441.666
#365	ZNF175	3	4	7	363.396
#366	ZNF18	3	13	16	295.407
#367	KLF7	3	10	13	141.993
#368	HR	3	15	18	397.966
#369	ZNF219	3	10	13	229.087
#370	CITED2	3	10	13	491.987
#371	GTF2H2	3	10	13	1186.088
#372	GLIS3	3	15	18	473.373
#373	GATAD1	3	13	16	636.103
#374	GATA4	3	7	10	204.064
#375	ETV7	3	6	9	156.141
#376	ESRRB	3	8	11	294.118
#377	ZNF483	3	10	13	215.79
#378	ERF	3	10	13	297.699
#379	ELF3	3	15	18	1114.166
#380	TCF12	3	14	17	573.678
#381	TGIF1	3	11	14	680.48
#382	TP73	3	11	14	396.697
#383	TSHZ2	2	13	15	356.966
#384	TEAD1	2	16	18	830.84
#385	TFDP2	2	9	11	178.451
#386	C2orf3	2	11	13	826.445
#387	NFYA	2	9	11	519.908
#388	ENO1	2	10	12	88.734
#389	ELK4	2	10	12	95.532
#390	TRERF1	2	15	17	944.69
#391	WNT5A	2	11	13	197.368
#392	MYC	2	11	13	238.168
#393	FOXL1	2	10	12	277.1
#394	MYNN	2	13	15	414.793
#395	TWIST2	2	19	21	567.596
#396	NKX6-2	2	8	10	105.79
#397	JUND	2	11	13	241.387
#398	MSL3	2	15	17	271.781
#399	IRF5	1	13	14	51.414
#400	FOXO1	1	6	7	48.291
#401	BACH2	1	14	15	89.774
#402	DLX3	1	9	10	28.252
#403	OTX1	0	8	8	0