Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	RERE	40	5	45	2488.369
#2	SPEN	39	4	43	981.336
#3	SOX2	39	6	45	1541.009
#4	LMO4	34	4	38	1780.901
#5	YEATS4	34	5	39	1241.876
#6	NME2	33	5	38	1027.346
#7	TAF6	32	4	36	749.989
#8	PITX1	32	10	42	4635.38
#9	ATF1	31	2	33	98.164
#10	TP63	31	7	38	2189.771
#11	ZNF189	31	6	37	3515.65
#12	PEG3	30	8	38	2410.953
#13	TGIF2	29	5	34	1952.259
#14	TRIM28	29	4	33	893.766
#15	ETS1	29	9	38	9305.659
#16	ZGPAT	28	7	35	796.105
#17	FOSL1	28	8	36	1108.342
#18	JUND	28	10	38	1494.554
#19	SOX21	28	5	33	1223.627
#20	IRF8	28	1	29	215.669
#21	BNC1	27	6	33	3294.607
#22	NR3C2	27	3	30	1651.571
#23	ESR1	27	6	33	665.122
#24	YY1	27	1	28	9.62
#25	SP3	26	1	27	19.105
#26	FOXJ3	26	5	31	450.443
#27	EHF	26	10	36	5450.073
#28	SOLH	25	12	37	5084.941
#29	TAF4	25	7	32	550.833
#30	CBFA2T2	25	7	32	1177.889
#31	GABPA	25	5	30	1070.237
#32	ATF2	24	4	28	2238.308
#33	TEF	24	13	37	2235.051
#34	E2F2	24	8	32	955.189
#35	ZNF135	24	4	28	749.578
#36	MEIS1	24	8	32	2180.608
#37	TULP4	24	5	29	1198.967
#38	NFYA	23	6	29	382.182
#39	TEAD2	23	9	32	1629.575
#40	RARB	23	10	33	2159.237
#41	RORA	23	17	40	3551.858
#42	HOXB3	23	6	29	988.389
#43	TCF4	22	11	33	1675.883
#44	HNRNPK	22	2	24	625.113
#45	TCF3	22	7	29	1906.958
#46	SALL2	22	16	38	2724.416
#47	ZNF444	22	6	28	1452.936
#48	ZFHX3	22	11	33	2392.259
#49	ZEB2	22	9	31	2208.108
#50	FOXK1	22	7	29	1560.312
#51	CNBP	22	9	31	472.589
#52	NFKB2	21	10	31	1785.678
#53	SNAPC4	21	2	23	82.039
#54	PA2G4	21	12	33	1231.894
#55	EDF1	21	11	32	1089.183
#56	CSRNP3	21	9	30	2177.073
#57	ZXDA	20	3	23	137.518
#58	SNAI2	20	11	31	4717.707
#59	SP140	20	2	22	960.578
#60	SIX4	20	8	28	925.546
#61	NFE2L2	20	4	24	1652.168
#62	GABPB1	20	11	31	4392.619
#63	TARDBP	19	10	29	1721.152
#64	HSF4	19	5	24	5702.635
#65	DMTF1	19	6	25	1182.02
#66	HCFC1	19	6	25	1958.605
#67	TSC22D1	19	8	27	6545.023
#68	GRHL3	19	7	26	2430.025
#69	IRF3	19	8	27	1207.18
#70	LCOR	19	9	28	372.677
#71	IRF4	19	7	26	5021.939
#72	HMGB1	19	6	25	2303.683
#73	SP4	19	11	30	1066.532
#74	KLF10	19	3	22	252.354
#75	ETV3	18	12	30	1753.892
#76	CNOT8	18	6	24	2286.467
#77	MTA2	18	10	28	1220.924
#78	NFKB1	18	13	31	1494.443
#79	E4F1	18	4	22	540.522
#80	OVOL1	18	9	27	1416.508
#81	NR2F1	18	6	24	481.166
#82	TFAP2C	18	7	25	619.026
#83	E2F7	18	11	29	1640.867
#84	HMGB2	18	4	22	90.894
#85	BATF2	18	3	21	2535.416
#86	RORB	18	9	27	2081.867
#87	PCGF6	18	6	24	5398.085
#88	GTF2I	18	10	28	1502.773
#89	ZNF281	18	4	22	229.418
#90	ZBTB38	18	9	27	2434.059
#91	SOX15	18	15	33	5093.938
#92	UBN1	17	10	27	437.179
#93	ZFPM1	17	10	27	1741.602
#94	FOXA1	17	22	39	4323.913
#95	ZRANB2	17	7	24	1624.272
#96	TSHZ2	17	11	28	1129.575
#97	MAFF	17	5	22	9973.58
#98	ZHX1	17	5	22	291.227
#99	BHLHE40	17	18	35	1511.442
#100	GLI3	17	8	25	992.535
#101	MZF1	17	13	30	1893.633
#102	HR	17	12	29	1255.862
#103	STAT1	17	3	20	1699.569
#104	STAT5A	17	8	25	5696.369
#105	HLF	17	8	25	1452.366
#106	MEIS3P1	17	13	30	2624.183
#107	ZFP36L1	17	5	22	181.698
#108	AEBP1	16	5	21	854.809
#109	RARA	16	15	31	2143.068
#110	AR	16	13	29	2238.355
#111	ETV6	16	13	29	1536.524
#112	NR1D2	16	4	20	125.262
#113	NR2C1	16	5	21	551.717
#114	HES6	16	9	25	1831.49
#115	ETS2	16	18	34	3431.469
#116	SNAPC5	16	5	21	6860.456
#117	HOXB4	16	6	22	2506.105
#118	RORC	16	11	27	1880.18
#119	NKX3-1	16	8	24	1462.37
#120	PPARD	16	6	22	1146.513
#121	CREBBP	16	6	22	830.828
#122	TCF20	16	13	29	1155.2
#123	GATAD2B	16	12	28	1258.832
#124	RCOR2	16	13	29	2741.192
#125	STAT4	16	3	19	248.331
#126	FOXM1	16	9	25	1227.42
#127	PRDM1	16	8	24	1980.112
#128	LHX2	16	20	36	6538.738
#129	PTTG1	16	13	29	3161.186
#130	MYCN	16	11	27	2046.029
#131	NR2F6	16	12	28	2810.757
#132	LZTR1	15	7	22	499.585
#133	REL	15	7	22	1885.29
#134	ELF2	15	8	23	541.483
#135	CTBP1	15	11	26	941.005
#136	RXRA	15	10	25	1152.658
#137	ZXDC	15	13	28	666.46
#138	FOXJ2	15	10	25	1153.327
#139	NFIX	15	14	29	2588.051
#140	GCFC1	15	14	29	4433.45
#141	STAT2	15	8	23	4625.404
#142	SOX17	15	2	17	355.807
#143	NR2F2	15	10	25	927.326
#144	NR4A2	15	17	32	3054.606
#145	NFIC	15	9	24	1039.885
#146	SIX5	15	7	22	523.834
#147	RB1	15	3	18	852.55
#148	AHR	14	10	24	1368.886
#149	TCF7L1	14	12	26	784.824
#150	TRIM25	14	9	23	2491.386
#151	PRRX1	14	13	27	2206.705
#152	ZSCAN18	14	12	26	4103.986
#153	SRF	14	13	27	955.412
#154	HMGA1	14	16	30	4662.457
#155	NOTCH1	14	9	23	7651.686
#156	CCRN4L	14	13	27	1601.809
#157	GATAD2A	14	9	23	646.323
#158	UHRF1	14	12	26	495.463
#159	HEYL	14	8	22	1280.722
#160	SPI1	14	2	16	130.996
#161	FBXW7	14	9	23	1140.256
#162	NFIB	14	20	34	4516.934
#163	HOXA6	14	4	18	657.026
#164	THRA	14	7	21	561.611
#165	RAX2	14	6	20	1197.083
#166	NOLC1	14	16	30	2951.024
#167	SIX1	14	7	21	569.927
#168	ZSCAN16	14	8	22	981.751
#169	JUNB	14	11	25	2320.916
#170	ETV7	14	8	22	1613.098
#171	MNT	14	12	26	1319.929
#172	CIR1	14	1	15	21.839
#173	HCLS1	13	5	18	1514.164
#174	TSC22D2	13	6	19	979.878
#175	MTF1	13	10	23	751.369
#176	SMAD5	13	12	25	1008.396
#177	ZBTB48	13	8	21	5576.501
#178	DMRT2	13	10	23	1184.419
#179	ETV5	13	14	27	2032.504
#180	MESP1	13	14	27	1486.799
#181	GTF2IRD1	13	13	26	1911.816
#182	FOXP2	13	15	28	2276.127
#183	SPDEF	13	11	24	1682.351
#184	IRX3	13	12	25	2360.098
#185	MSX1	13	10	23	1585.734
#186	PBX1	13	15	28	2205.646
#187	ZNF133	13	10	23	1416.831
#188	EBF1	13	5	18	740.802
#189	MEF2C	13	10	23	1576.981
#190	ATF4	12	4	16	197.105
#191	SCAND1	12	13	25	1982.449
#192	ZNF35	12	10	22	867.595
#193	RFXAP	12	12	24	1022.519
#194	PLAGL2	12	10	22	576.582
#195	MYNN	12	6	18	470.911
#196	RUNX1	12	12	24	995.759
#197	GTF2H3	12	11	23	918.887
#198	C5orf41	12	12	24	1877.45
#199	VAV1	12	5	17	204.316
#200	ADNP	12	4	16	104.935
#201	XBP1	12	12	24	644.387
#202	TCEAL1	12	11	23	962.291
#203	USF2	12	14	26	2612.839
#204	HOXA2	12	4	16	239.307
#205	ZNF232	12	12	24	559.05
#206	TRIM22	12	5	17	290.497
#207	IRF1	12	7	19	1399.566
#208	ELF1	12	10	22	583.637
#209	PLSCR1	12	11	23	3723.819
#210	TFDP1	12	11	23	697.777
#211	ELF3	12	11	23	811.766
#212	TSHZ1	12	15	27	816.919
#213	TRPS1	11	9	20	1955.988
#214	PBX4	11	11	22	600.651
#215	ZNF256	11	9	20	1377.895
#216	NFE2L3	11	13	24	1585.051
#217	HIF1A	11	5	16	83.864
#218	ZNF33B	11	7	18	453.741
#219	HOXB2	11	11	22	856.977
#220	TRIM29	11	19	30	1231.716
#221	MAX	11	9	20	988.936
#222	TFAM	11	12	23	1022.127
#223	MEF2A	11	6	17	746.506
#224	DRAP1	11	7	18	656.513
#225	MAFB	11	15	26	1678.181
#226	HOXD9	11	13	24	2870.871
#227	SMAD4	11	13	24	1383.838
#228	TAF1B	11	7	18	344.906
#229	MYC	11	7	18	783.191
#230	YBX1	11	6	17	1354.162
#231	ZFP90	11	13	24	1918.431
#232	GAS7	11	12	23	828.352
#233	ZNF134	11	19	30	2010.208
#234	EPAS1	11	12	23	1937.706
#235	HSF2	11	9	20	1205.789
#236	HNRNPAB	10	10	20	1219.04
#237	HOXB6	10	5	15	618.331
#238	IRX5	10	20	30	2160.067
#239	E2F5	10	14	24	2022.941
#240	ESRRG	10	11	21	1827.836
#241	EOMES	10	5	15	5799.965
#242	ETV4	10	10	20	1443.873
#243	ZNF91	10	12	22	1962.725
#244	CTNNB1	10	16	26	1746.533
#245	ZNF193	10	11	21	742.209
#246	CBL	10	5	15	196.972
#247	TSHZ3	10	12	22	1405.08
#248	DLX1	10	11	21	1029.428
#249	HDAC1	10	13	23	549.014
#250	MYPOP	10	8	18	1853.292
#251	BATF	10	9	19	2229.775
#252	SOX7	10	19	29	1103.409
#253	KLF5	10	5	15	84.694
#254	TBX19	10	10	20	814.487
#255	CREB5	9	15	24	1282.356
#256	MSRB2	9	14	23	1065.558
#257	ISL1	9	10	19	908.946
#258	TAF13	9	8	17	1315.06
#259	NR1H3	9	11	20	1335.805
#260	ATF6	9	7	16	317.748
#261	MSL3	9	9	18	1279.315
#262	SCAND3	9	9	18	1574.733
#263	CNOT7	9	10	19	1460.665
#264	MAFG	9	13	22	1826.137
#265	MECOM	9	15	24	1787.89
#266	RFX5	9	11	20	2071.632
#267	TBX2	9	12	21	1538.73
#268	HOXC8	9	7	16	748.567
#269	HOXD1	9	16	25	712.074
#270	GATA2	9	12	21	1088.036
#271	OTX1	9	17	26	1281.466
#272	GTF2H4	9	11	20	999.325
#273	MXD1	9	12	21	773.071
#274	ZNF138	9	14	23	1828.999
#275	TAF12	9	11	20	671.314
#276	CEBPB	9	13	22	1119.255
#277	RBPJ	9	15	24	1029.021
#278	TCF25	9	8	17	792.073
#279	RBCK1	9	11	20	1675.47
#280	DLX3	9	15	24	2204.745
#281	ZNF274	9	8	17	923.169
#282	ELF4	9	14	23	1262.629
#283	ZNF69	9	5	14	244.098
#284	HOXB5	9	11	20	646.977
#285	HOXD10	9	10	19	2787.648
#286	FOXO3	8	11	19	1203.369
#287	GLIS3	8	13	21	1185.279
#288	NFIL3	8	12	20	404.621
#289	SREBF1	8	21	29	1793.395
#290	ELF5	8	19	27	1247.128
#291	NFE2	8	18	26	2624.491
#292	BCL3	8	14	22	1610.102
#293	ZNF213	8	12	20	1398.599
#294	PCGF2	8	17	25	682.035
#295	MSC	8	16	24	1899.605
#296	ZFP36L2	8	6	14	311.082
#297	CSRNP1	8	13	21	1459.452
#298	AATF	8	13	21	1665.711
#299	SMAD3	8	18	26	1095.16
#300	RCAN1	8	16	24	2136.956
#301	STRN3	8	11	19	826.781
#302	TFDP2	8	13	21	905.891
#303	HEY1	8	18	26	1741.139
#304	ZNF83	8	17	25	1360.122
#305	BCL6	8	15	23	830.41
#306	ARNT2	8	15	23	3791.455
#307	MAF	8	13	21	1370.857
#308	BCL11B	8	17	25	1891.857
#309	HDAC2	8	8	16	311.361
#310	HES1	8	16	24	1959.383
#311	PHF5A	8	11	19	683.798
#312	PURB	8	9	17	1383.508
#313	ZFHX4	8	15	23	1680.226
#314	ZNF217	8	14	22	2018.838
#315	RELB	8	14	22	1399.54
#316	C1orf85	8	12	20	546.363
#317	SNAPC2	8	12	20	836.544
#318	NFAT5	8	11	19	791.768
#319	HOXA3	7	8	15	295.356
#320	TCF12	7	13	20	1107.623
#321	SOX4	7	19	26	2237.171
#322	CDKN2A	7	18	25	1563.779
#323	FOXD2	7	15	22	862.976
#324	BLZF1	7	8	15	1167.408
#325	IRF6	7	14	21	1450.97
#326	SOX18	7	13	20	798.745
#327	TSC22D3	7	15	22	1786.48
#328	RFXANK	7	12	19	1013.094
#329	SOX11	7	8	15	535.608
#330	HOXC6	7	16	23	1294.063
#331	GRHL2	7	15	22	1131.837
#332	DBP	7	12	19	533.969
#333	HOPX	7	16	23	2341.581
#334	TAF7	7	14	21	2286.78
#335	MTA3	7	11	18	2399.039
#336	ARID3A	7	14	21	1577.682
#337	LASS2	7	13	20	681.92
#338	ZNF483	7	8	15	959.742
#339	HOXA5	7	10	17	430.493
#340	TWIST1	7	23	30	1921.103
#341	SCMH1	7	9	16	2554.6
#342	TBX1	7	12	19	2063.422
#343	FOXN3	7	19	26	781.816
#344	HOXB7	7	8	15	368.776
#345	NFATC1	6	12	18	1291.253
#346	STAT3	6	9	15	474.507
#347	MGA	6	5	11	85.728
#348	GATA3	6	15	21	975.801
#349	HOXD11	6	12	18	1392.054
#350	LHX3	6	10	16	868.098
#351	LZTS1	6	20	26	1928.446
#352	LEF1	6	16	22	883.943
#353	HES5	6	16	22	2057.357
#354	CSDA	6	11	17	316.348
#355	MEF2D	6	16	22	1213.245
#356	MKX	6	13	19	2117.995
#357	CUX1	6	9	15	964.944
#358	FOXO4	6	15	21	785.027
#359	FOXA3	6	13	19	837.645
#360	KLF11	6	14	20	523.989
#361	WNT5A	6	11	17	240.196
#362	E2F3	6	17	23	1116.832
#363	IRX6	6	15	21	1461.538
#364	LASS6	6	15	21	1085.271
#365	AFF4	6	12	18	850.475
#366	TCF19	6	16	22	849.753
#367	SOX13	6	16	22	559.497
#368	BTG2	6	15	21	518.187
#369	TEAD4	6	15	21	708.768
#370	C11orf9	6	8	14	386.506
#371	TP53	6	17	23	970.498
#372	HOXA10	6	14	20	1982.736
#373	HHEX	6	9	15	345.761
#374	TFAP2A	6	16	22	818.367
#375	ZNF277	6	10	16	369.257
#376	SPIB	6	10	16	620.99
#377	AHCTF1	6	11	17	878.494
#378	CEBPD	6	16	22	1380.979
#379	ATF5	6	15	21	2449.54
#380	FOXC2	5	15	20	1163.432
#381	FOSB	5	13	18	482.956
#382	HOXB8	5	10	15	454.954
#383	FOXQ1	5	19	24	498.074
#384	KLF4	5	17	22	1307.841
#385	PAX8	5	14	19	3574.486
#386	IKZF1	5	11	16	1644.185
#387	NFIA	5	14	19	892.139
#388	FOXE1	5	22	27	2796.257
#389	ZFP37	5	16	21	638.41
#390	HEY2	5	18	23	1356.146
#391	RUNX3	5	16	21	458.097
#392	FOXL2	5	18	23	1308.009
#393	NKX3-2	5	10	15	199.129
#394	KLF2	5	13	18	1140.36
#395	KLF9	5	17	22	778.457
#396	TGIF1	5	9	14	498.837
#397	HOXC9	5	10	15	396.307
#398	CREB1	5	9	14	1324.209
#399	ZNF219	5	13	18	1209.099
#400	ZNF148	5	11	16	600.63
#401	BATF3	5	10	15	1674.13
#402	POU3F1	5	12	17	1184.24
#403	MTA1	5	16	21	1187.614
#404	ERF	5	15	20	1303.851
#405	IRF9	5	7	12	1536.449
#406	ZNF175	5	15	20	1771.572
#407	ZNF18	5	12	17	385.675
#408	SATB2	5	18	23	1867.667
#409	PBX2	5	13	18	1654.372
#410	NFE2L1	5	9	14	1071.979
#411	MMP14	5	17	22	793.202
#412	TADA3	5	9	14	1155.859
#413	SLC2A4RG	5	19	24	1578.843
#414	NFYC	5	15	20	571.641
#415	UBP1	5	7	12	924.859
#416	EGR2	4	11	15	342.735
#417	TRERF1	4	17	21	580.777
#418	BHLHE41	4	15	19	1725.332
#419	FOXF2	4	17	21	344.473
#420	ZNF394	4	8	12	1146.369
#421	CREBZF	4	11	15	319.125
#422	FOXC1	4	18	22	1650.326
#423	TFCP2L1	4	14	18	336.156
#424	PRRX2	4	18	22	860.522
#425	FOXD1	4	18	22	864.606
#426	ONECUT2	4	21	25	2960.23
#427	ZFP42	4	15	19	1048.909
#428	ATF3	4	18	22	1229.434
#429	MAFA	4	11	15	572.361
#430	MEOX1	4	14	18	795.107
#431	PBX3	4	18	22	1091.979
#432	IRX2	4	18	22	1002.88
#433	CEBPA	4	18	22	752.384
#434	ZNF215	4	16	20	618.999
#435	STAT6	4	14	18	878.777
#436	NFX1	4	4	8	27.91
#437	FOS	4	12	16	290.876
#438	SMAD6	4	13	17	438.958
#439	CITED2	4	13	17	1503.697
#440	FOXJ1	3	12	15	241.854
#441	SIM2	3	12	15	1050.327
#442	FOXN2	3	17	20	402.733
#443	TBX3	3	14	17	529.852
#444	POU5F1	3	19	22	783.838
#445	LASS5	3	12	15	879.878
#446	KLF6	3	23	26	1466.498
#447	CREB3L2	3	17	20	411.311
#448	HOXA13	3	13	16	901.086
#449	SLC30A9	3	16	19	348.419
#450	LHX6	3	16	19	332.119
#451	MEIS2	3	19	22	227.245
#452	NR1H2	3	9	12	423.389
#453	ALX1	3	16	19	462.017
#454	FOXA2	3	8	11	279.646
#455	PAX7	3	14	17	737.98
#456	PITX2	3	21	24	1204.35
#457	HOXA9	3	9	12	1092.659
#458	DMRT1	3	13	16	678.4
#459	HMG20B	3	10	13	102.244
#460	SOX9	2	17	19	325.301
#461	ZSCAN5A	2	16	18	367.515
#462	PRDM2	2	9	11	364.91
#463	MYT1	2	10	12	658.111
#464	VTN	2	7	9	241.205
#465	PPARG	2	18	20	854.406
#466	HOXC4	2	13	15	324.456
#467	HMBOX1	2	12	14	218.184
#468	ZIC2	2	17	19	330.504
#469	MBD1	2	13	15	167.539
#470	IRF7	2	8	10	177.071
#471	ZNF165	2	16	18	892.135
#472	KDM5B	2	20	22	146.124
#473	BARX1	2	9	11	196.963
#474	ASCL2	2	16	18	378.801
#475	USF1	2	16	18	823.161
#476	NR2C2	2	14	16	281.636
#477	IRF5	2	12	14	1165.985
#478	KLF12	2	12	14	116.297
#479	EGR1	2	16	18	415.161
#480	NR2E3	1	10	11	71.728
#481	ARNTL	1	9	10	37.091
#482	IRX4	1	23	24	173.89
#483	PLAG1	1	20	21	902.997
#484	POU4F1	1	13	14	123.439
#485	ZNF323	1	16	17	585.698
#486	TAF10	1	15	16	220.497
#487	DDIT3	1	16	17	180.423
#488	NPAS2	1	19	20	96.902
#489	NKX2-5	1	16	17	1193.042
#490	JUN	1	18	19	98.473
#491	HOXA4	1	17	18	119.461
#492	HOXC13	1	18	19	562.299
#493	PHTF1	1	14	15	76.343
#494	RUNX2	1	16	17	102.586
#495	ZNF75D	0	13	13	0
#496	TCFL5	0	12	12	0
#497	HMX2	0	15	15	0
#498	PAX6	0	16	16	0
#499	SCML1	0	16	16	0
#500	ZHX2	0	14	14	0