Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	FOXA1	85	1	86	9.889
#2	GATA3	70	5	75	102.912
#3	SPDEF	70	1	71	508.277
#4	XBP1	67	3	70	2268.032
#5	ESR1	64	4	68	388.416
#6	FOXC1	58	2	60	1010.88
#7	RBPJ	56	4	60	2359.355
#8	GTF2I	51	2	53	30.135
#9	MAX	48	6	54	239.358
#10	NFIB	47	15	62	1098.263
#11	TSC22D3	46	5	51	176.345
#12	ZXDC	46	9	55	823.639
#13	E2F2	45	4	49	209.652
#14	MEIS3P1	45	6	51	78.944
#15	CEBPB	44	7	51	2882.105
#16	KLF11	43	10	53	1135.045
#17	TCEAL1	42	7	49	3260.808
#18	ANKRD30A	42	24	66	1945.485
#19	FOXM1	41	9	50	578.651
#20	GATAD2A	41	3	44	185.183
#21	CDKN2A	41	11	52	1103.162
#22	ZEB2	40	5	45	485.069
#23	ELF5	40	16	56	1151.496
#24	PTTG1	40	3	43	234.658
#25	TBX19	40	10	50	898.403
#26	PRDM2	39	8	47	1243.41
#27	CREB3L4	38	6	44	299.955
#28	HMGA1	37	15	52	2321.301
#29	RUNX3	36	20	56	993.188
#30	PRRX1	36	9	45	1422.761
#31	TRIM29	36	12	48	843.84
#32	RB1	35	9	44	358.467
#33	LASS2	35	8	43	1435.631
#34	FLI1	35	4	39	828.296
#35	ZEB1	35	5	40	498.695
#36	BTG2	34	10	44	252.306
#37	TCF7L2	34	10	44	1543.955
#38	FOXL1	34	13	47	1565.676
#39	TAF13	34	5	39	564.178
#40	SP3	34	13	47	2127.472
#41	TFCP2L1	33	16	49	799.011
#42	RUNX2	33	3	36	699.329
#43	SP1	33	5	38	146.028
#44	PRDM1	33	4	37	152.462
#45	TRPS1	33	11	44	2061.959
#46	ZNF91	32	17	49	1491.655
#47	MLLT10	32	10	42	1034.076
#48	NFIL3	32	17	49	1284.343
#49	AR	32	12	44	406.68
#50	MYC	32	8	40	803.634
#51	CTNNB1	31	8	39	143.17
#52	ARNTL2	31	13	44	1798.821
#53	TFEC	31	4	35	750.757
#54	ARNT	30	16	46	748.025
#55	HIF1A	30	23	53	1307.853
#56	KLF5	30	15	45	844.17
#57	SMAD4	29	12	41	1366.274
#58	E2F3	29	10	39	527.876
#59	PPARD	29	11	40	593.052
#60	SALL2	29	7	36	318.572
#61	LEF1	29	19	48	2185.442
#62	CREB3L1	29	9	38	3055.989
#63	BHLHE40	29	13	42	679.639
#64	HHEX	29	12	41	1990.778
#65	ZNF367	28	6	34	88.481
#66	SUPT6H	28	6	34	438.122
#67	LASS6	28	17	45	906.145
#68	PGR	27	12	39	446.243
#69	IKZF4	27	15	42	1110.937
#70	EN1	27	14	41	747.88
#71	FOXH1	27	9	36	1226.993
#72	GLI3	27	13	40	450.879
#73	MAFB	26	13	39	574.635
#74	MSX2	26	14	40	544.84
#75	CREB3	26	14	40	1168.359
#76	CREBL2	26	12	38	612.716
#77	TAF4B	26	13	39	596.395
#78	PBX1	26	17	43	962.194
#79	IKZF1	26	7	33	427.294
#80	FOXO3	26	13	39	704.143
#81	ZKSCAN3	26	12	38	1049.863
#82	HCLS1	26	6	32	213.883
#83	HSF2	25	17	42	953.489
#84	ATF7	25	14	39	1654.716
#85	UHRF1	25	11	36	518.347
#86	LMO4	25	14	39	738.927
#87	PURB	25	7	32	803.067
#88	DLX6	25	9	34	120.054
#89	HOXA9	25	10	35	1965.602
#90	CSDA	25	16	41	1452.214
#91	MEF2C	25	14	39	1480.688
#92	CEBPA	24	12	36	831.889
#93	IRF8	24	3	27	87.032
#94	TAF5	24	11	35	858.129
#95	ZNF33A	24	20	44	1274.255
#96	C5orf41	24	12	36	862.704
#97	HOXB2	24	12	36	589.097
#98	REST	24	11	35	625.99
#99	ZNF281	24	8	32	487.766
#100	RARA	23	16	39	1236.053
#101	SOX11	23	17	40	855.328
#102	TEAD4	23	10	33	494.954
#103	RCAN1	23	18	41	1173.038
#104	DMRT1	23	11	34	964.996
#105	MEOX2	23	11	34	566.244
#106	SIN3A	23	16	39	1297.602
#107	TEAD3	23	21	44	1189.01
#108	ETV7	23	13	36	786.329
#109	NFATC2	23	16	39	1583.402
#110	ZNF148	23	14	37	1128.14
#111	ZNF483	23	19	42	1162.513
#112	HOXB6	23	7	30	423.213
#113	NANOG	23	18	41	1274.886
#114	SMAD3	23	19	42	780.351
#115	CSRNP2	22	13	35	978.556
#116	TCF4	22	7	29	259.959
#117	NR2F1	22	18	40	1152.859
#118	TSHZ1	22	10	32	353.935
#119	RXRB	22	16	38	2105.041
#120	BACH1	22	15	37	714.731
#121	STAT2	22	15	37	1846.594
#122	GATAD2B	22	20	42	787.608
#123	SOX10	22	15	37	635.013
#124	CREB3L2	22	13	35	1075.455
#125	JUN	22	15	37	1354.748
#126	ZNF92	22	17	39	1291.193
#127	TSHZ3	22	11	33	447.618
#128	HDAC2	21	20	41	1458.727
#129	TBX5	21	10	31	679.048
#130	ENO1	21	17	38	462.973
#131	E2F5	21	15	36	1077.079
#132	TAF5L	21	15	36	747.992
#133	ZNF192	21	15	36	1197.181
#134	GAS7	21	6	27	175.556
#135	ZIC1	21	16	37	437.267
#136	TBX3	21	22	43	1404.441
#137	TULP4	21	14	35	880.452
#138	MNX1	21	21	42	1150.121
#139	BCL3	21	23	44	2172.771
#140	ZNF236	21	21	42	2164.865
#141	HOXA10	21	13	34	1129.438
#142	HOXA3	20	16	36	1157.212
#143	ZSCAN16	20	11	31	1514.031
#144	TFAP2A	20	19	39	2011.735
#145	TRERF1	20	23	43	4140.817
#146	SATB1	20	20	40	1138.121
#147	ZNF217	20	10	30	419.004
#148	ETS1	20	15	35	1168.823
#149	SREBF1	20	22	42	762.239
#150	ZNF140	20	17	37	1020.139
#151	EOMES	20	12	32	796.87
#152	ZNF207	20	17	37	1007.578
#153	AHCTF1	20	21	41	1430.63
#154	ATF1	20	16	36	1856.685
#155	E2F8	20	13	33	410.335
#156	TEAD2	19	21	40	1728.334
#157	ZKSCAN1	19	23	42	1967.11
#158	TGIF2	19	17	36	556.382
#159	NR2E1	19	18	37	1959.041
#160	POU4F1	19	14	33	1374.374
#161	TRIM22	19	8	27	262.08
#162	SOX8	19	12	31	1457.796
#163	FOXD1	19	21	40	1170.439
#164	HOXB3	19	11	30	575.029
#165	HOXB4	19	9	28	1573.567
#166	FOXO1	19	17	36	1693.217
#167	FOSL1	19	16	35	1005.465
#168	AFF1	19	12	31	797.017
#169	ZNF18	18	17	35	935.755
#170	SIX3	18	17	35	547.76
#171	FOXN2	18	14	32	851.547
#172	SP140	18	21	39	1642.723
#173	HOPX	18	22	40	941.39
#174	TFEB	18	21	39	1426.625
#175	AEBP1	18	5	23	358.903
#176	EPAS1	18	17	35	884.625
#177	ZNF496	18	20	38	1715.777
#178	TCF19	18	14	32	229.607
#179	TCF12	18	20	38	1783.994
#180	TWIST1	18	18	36	3002.049
#181	AFF4	18	16	34	1113.882
#182	KDM5B	18	12	30	1044.262
#183	EGR1	17	15	32	1302.674
#184	HOXC13	17	9	26	1383.842
#185	IRX5	17	15	32	635.964
#186	STAT3	17	19	36	863.756
#187	ZNF3	17	20	37	1389.041
#188	SPIB	17	17	34	1387.179
#189	HOXA7	17	8	25	510.26
#190	STAT1	17	14	31	994.893
#191	CBFA2T2	17	19	36	2280.532
#192	ZNF45	17	21	38	1268.641
#193	MECOM	17	22	39	1089.237
#194	NFIA	17	18	35	658.039
#195	FOXG1	17	12	29	655.952
#196	RARG	17	16	33	1120.894
#197	E2F7	17	20	37	1067.515
#198	CUX1	17	18	35	1042.296
#199	BCL11B	17	21	38	1142.726
#200	NFIX	17	26	43	2575.895
#201	ELK4	17	17	34	1150.068
#202	HOXC11	17	13	30	548.16
#203	KLF7	17	16	33	1093.952
#204	SLC30A9	17	15	32	791.103
#205	AHR	16	22	38	1179.169
#206	ARNT2	16	16	32	846.113
#207	GCFC1	16	19	35	750.177
#208	IRF1	16	17	33	887.157
#209	GLIS2	16	8	24	377.455
#210	TFAP2C	16	21	37	1055.042
#211	NR1H3	16	19	35	745.953
#212	HOXA1	16	14	30	1356.719
#213	ZNF643	16	17	33	1022.717
#214	MYNN	16	21	37	1566.322
#215	GTF2H2	16	18	34	954.925
#216	FOXK2	16	23	39	1049.899
#217	NR2E3	16	22	38	1290.839
#218	MAFF	16	21	37	1309.638
#219	HOXB5	16	8	24	682.273
#220	BATF2	16	10	26	466.299
#221	IRX3	16	17	33	1230.633
#222	GLIS3	16	11	27	524.718
#223	ZFP36L1	16	19	35	1511.172
#224	ARID4A	16	17	33	2479.704
#225	EGR2	16	23	39	1824.088
#226	WNT5A	16	20	36	1471.386
#227	L3MBTL4	15	23	38	1744.042
#228	ZNF397	15	16	31	896.418
#229	HR	15	17	32	854.944
#230	ZBTB25	15	21	36	1481.551
#231	ERG	15	17	32	1085.073
#232	ZRANB2	15	12	27	1213.831
#233	IRX1	15	19	34	828.835
#234	TFAP2B	15	25	40	1649.251
#235	NKX3-1	15	16	31	972.77
#236	RUNX1	15	16	31	826.155
#237	STAT4	15	14	29	527.61
#238	GATA6	15	22	37	1158.326
#239	C1orf85	15	21	36	1253.877
#240	EGR3	15	11	26	641.552
#241	FOXF2	15	16	31	1123.371
#242	CNOT8	15	17	32	706.374
#243	ZFHX3	15	14	29	703.273
#244	NR4A2	15	21	36	1068.447
#245	SMAD5	15	14	29	586.518
#246	HIF3A	15	10	25	319.995
#247	BLZF1	15	18	33	1571.491
#248	ZNF396	15	26	41	956.721
#249	HMBOX1	15	14	29	436.102
#250	SNAI2	15	18	33	656.848
#251	CBL	15	19	34	629.461
#252	FOSB	14	17	31	927.094
#253	WT1	14	24	38	2434.092
#254	ESRRG	14	23	37	1125.472
#255	KLF4	14	26	40	1474.35
#256	ZNF165	14	23	37	1019.348
#257	CREB5	14	20	34	1677.615
#258	RUNX1T1	14	18	32	586.529
#259	PLSCR1	14	18	32	1193.451
#260	PAX6	14	15	29	863.107
#261	MITF	14	23	37	1185.836
#262	FOXP4	14	18	32	1836.213
#263	CITED2	14	20	34	1064.17
#264	ZNF256	14	14	28	830.91
#265	RORC	14	15	29	497.453
#266	PPARG	14	15	29	705.286
#267	TEAD1	14	16	30	1270.113
#268	ZNF202	14	20	34	1394.124
#269	MESP1	14	16	30	1751.107
#270	ETV3	14	15	29	797.2
#271	ZNF639	14	15	29	445.9
#272	FOXC2	14	16	30	1093.709
#273	HES1	14	22	36	1094.121
#274	NR1D2	14	12	26	465.564
#275	YY1	14	16	30	895.228
#276	ZNF268	14	12	26	548.412
#277	HOXD10	13	16	29	1070.791
#278	SOX13	13	15	28	748.821
#279	C2orf3	13	20	33	628.052
#280	KDM5A	13	17	30	1254.244
#281	ZNF134	13	25	38	1088.455
#282	IRX2	13	21	34	2308.371
#283	FOSL2	13	16	29	1040.904
#284	GATA2	13	18	31	458.503
#285	CCRN4L	13	25	38	1487.513
#286	RCOR2	13	17	30	822.467
#287	SOX9	13	16	29	641.947
#288	MYCL1	13	17	30	299.527
#289	ZNF33B	13	23	36	1679.595
#290	RFX3	13	26	39	1274.022
#291	THRB	13	19	32	721.126
#292	SOX6	13	17	30	631.6
#293	ETV1	12	20	32	606.06
#294	ZNF155	12	21	33	701.506
#295	EBF1	12	24	36	992.882
#296	ATF3	12	18	30	709.02
#297	PEG3	12	26	38	1671.351
#298	ZNF277	12	22	34	1192.648
#299	SLC26A3	12	17	29	1248.554
#300	FOS	12	16	28	646.354
#301	FOXP2	12	17	29	1190.624
#302	NR2C1	12	20	32	852.616
#303	HOXC10	12	16	28	1022.918
#304	TLX1	12	18	30	1688.9
#305	ETS2	12	17	29	704.389
#306	NFX1	12	18	30	743.095
#307	TP63	12	23	35	1119.167
#308	ZNF93	12	19	31	692.363
#309	THRA	12	18	30	870.328
#310	ZFPM2	12	15	27	445.512
#311	PBX4	12	18	30	778.728
#312	PURA	12	17	29	742.316
#313	TAF1B	12	21	33	634.293
#314	ZNF24	12	19	31	896.993
#315	KLF15	12	20	32	855.631
#316	MEIS2	12	16	28	658.5
#317	PAX7	12	21	33	968.97
#318	HES6	12	22	34	1200.088
#319	HOXC9	12	14	26	707.622
#320	ATF2	12	18	30	1535.151
#321	NFATC3	12	24	36	1308.903
#322	MEIS1	11	22	33	579.564
#323	TGIF1	11	17	28	1036.433
#324	SOX12	11	16	27	446.597
#325	ZNF117	11	23	34	1865.987
#326	ZNF238	11	22	33	4163.197
#327	ONECUT2	11	21	32	1831.471
#328	NFKB2	11	20	31	712.842
#329	NFATC4	11	17	28	857.211
#330	ZNF81	11	20	31	949.53
#331	TARDBP	11	17	28	640.223
#332	TFDP2	11	16	27	606.871
#333	NFATC1	11	21	32	858.241
#334	ZNF132	11	21	32	1096.34
#335	SP4	11	17	28	783.777
#336	STAT5B	11	20	31	990.129
#337	ZSCAN18	11	29	40	1044.798
#338	NPAS2	11	23	34	1067.208
#339	SLC2A4RG	11	17	28	567.421
#340	FOXP1	11	23	34	650.336
#341	DLX2	11	19	30	651.861
#342	MKX	11	22	33	1056.176
#343	PGBD1	11	19	30	916.437
#344	ALS2CR8	11	18	29	892.952
#345	CUX2	11	15	26	685.838
#346	SIM1	11	16	27	822.538
#347	IRF6	11	31	42	1440.739
#348	C12orf28	11	23	34	1480.233
#349	LHX2	11	19	30	889.346
#350	HMG20A	11	17	28	759.892
#351	HOXA5	11	13	24	728.229
#352	ELF4	10	16	26	756.799
#353	ZFHX4	10	18	28	847.532
#354	KLF12	10	22	32	810.65
#355	SOX2	10	21	31	1155.223
#356	ZSCAN12	10	20	30	684.111
#357	FOXI1	10	20	30	1087.008
#358	ZNF83	10	18	28	633.291
#359	TBX10	10	16	26	1114.781
#360	IRF9	10	18	28	471.956
#361	TFDP1	10	23	33	522.106
#362	TP53	10	24	34	2332.408
#363	MYT1	10	15	25	1238.852
#364	PCGF2	10	21	31	765.418
#365	HSF1	10	20	30	1132
#366	PLAGL2	10	21	31	832.509
#367	SCAND2	10	22	32	987.722
#368	IRF7	10	18	28	605.152
#369	ZSCAN2	10	19	29	976.099
#370	HOMEZ	10	23	33	627.314
#371	ATF5	10	13	23	764.921
#372	ASCL2	10	31	41	1675.153
#373	IKZF3	10	28	38	1128.229
#374	RARB	10	18	28	541.322
#375	DLX1	10	21	31	961.133
#376	FOXR2	9	10	19	541.784
#377	NFYB	9	25	34	1457.301
#378	KLF9	9	23	32	2157.36
#379	HIRA	9	16	25	322.635
#380	CNOT7	9	19	28	473.629
#381	BHLHE41	9	20	29	668.081
#382	HOXC4	9	16	25	506.559
#383	TCF7L1	9	20	29	563.508
#384	FOXA3	9	17	26	603.589
#385	FOXQ1	9	24	33	1038.398
#386	ZNF215	9	20	29	541.982
#387	MSL3	9	27	36	790.832
#388	SMAD1	9	19	28	870.498
#389	OVOL1	9	18	27	727.047
#390	HOXB8	9	21	30	649.311
#391	ZFP90	9	18	27	800.532
#392	ZNF167	9	22	31	1050.21
#393	TBX20	9	17	26	1005.905
#394	HOXA2	9	22	31	664.913
#395	HOXD8	9	27	36	571.891
#396	NR4A3	9	16	25	540.747
#397	HOXB13	9	19	28	859.63
#398	ZNF323	9	23	32	594.768
#399	HOXD4	9	28	37	1484.928
#400	STAT6	9	21	30	716.664
#401	TSC22D1	9	21	30	462.989
#402	NR2F2	9	29	38	1153.095
#403	PBX3	8	22	30	883.032
#404	HDX	8	19	27	486.332
#405	RORA	8	23	31	801.667
#406	TCF20	8	21	29	426.899
#407	CBFA2T3	8	18	26	712.121
#408	HOXD3	8	15	23	648.732
#409	ZHX1	8	17	25	479.308
#410	NR3C2	8	26	34	769.591
#411	ZNF174	8	20	28	635.808
#412	HEYL	8	26	34	766.354
#413	SALL1	8	20	28	662.494
#414	SOX7	8	19	27	447.038
#415	NFE2L3	8	15	23	534.388
#416	POU2F3	8	24	32	1032.053
#417	SCML1	8	23	31	683.071
#418	ZNF131	8	24	32	979.39
#419	GCM1	8	19	27	650.238
#420	NFYA	8	22	30	822.158
#421	HLF	8	28	36	1008.62
#422	DLX4	8	21	29	858.294
#423	BATF	8	22	30	969.221
#424	DLX3	8	16	24	683.105
#425	ZNF75D	8	16	24	984.334
#426	ZNF175	8	27	35	997.112
#427	ZNF70	8	20	28	558.934
#428	CTBP1	8	22	30	1676.003
#429	EHF	7	29	36	1376.098
#430	STAT5A	7	17	24	864.645
#431	ZNF434	7	20	27	640.528
#432	FOXN3	7	15	22	591.569
#433	SIM2	7	19	26	474.221
#434	HOXD1	7	21	28	463.275
#435	POU2F1	7	19	26	594.327
#436	MYCN	7	22	29	504.62
#437	PBX2	7	26	33	668.779
#438	REL	7	26	33	408.892
#439	RFX5	7	23	30	1419.762
#440	HMG20B	7	16	23	478.924
#441	MEOX1	7	18	25	509.582
#442	CREM	7	24	31	1229.8
#443	SIX1	7	25	32	736.402
#444	PITX1	7	16	23	746.264
#445	MESP2	7	17	24	509.21
#446	ZNF19	6	18	24	372.572
#447	CEBPD	6	23	29	622.237
#448	MAF	6	26	32	523.937
#449	POU6F1	6	22	28	419.122
#450	TSHZ2	6	24	30	397.45
#451	HEY1	6	23	29	764.595
#452	CITED1	6	17	23	265.003
#453	ZNF85	6	21	27	423.787
#454	ELF3	6	23	29	479.294
#455	SOX5	6	20	26	797.167
#456	PHTF1	6	25	31	3855.81
#457	HOXB7	6	20	26	283.702
#458	ZNF274	6	22	28	848.926
#459	SMAD9	6	22	28	473.789
#460	CREBZF	6	20	26	444.919
#461	TCFL5	6	21	27	556.182
#462	PROX1	6	16	22	265.653
#463	ZSCAN23	6	25	31	605.252
#464	KLF2	6	17	23	249.36
#465	BACH2	6	16	22	405.559
#466	RERE	5	16	21	483.368
#467	PKNOX1	5	21	26	507.421
#468	TSC22D2	5	18	23	406.03
#469	ZNF197	5	17	22	424.079
#470	TBX1	5	21	26	684.433
#471	TWIST2	5	18	23	380.412
#472	ZHX2	5	26	31	403.823
#473	BCL6	5	28	33	836.664
#474	NR5A2	5	19	24	733.884
#475	NKX2-1	5	12	17	140.966
#476	SIX4	5	21	26	415.975
#477	NFAT5	5	18	23	421.293
#478	SOX4	5	22	27	489.305
#479	ZNF135	5	18	23	624.736
#480	HEY2	4	20	24	250.828
#481	SIX2	4	23	27	752.417
#482	ASCL1	4	17	21	252.632
#483	TFE3	4	21	25	476.161
#484	NR3C1	4	26	30	455.1
#485	SOX17	4	21	25	334.63
#486	VDR	4	19	23	275.376
#487	MLL	4	21	25	488.166
#488	DDIT3	4	24	28	674.51
#489	PKNOX2	4	17	21	388.717
#490	ARX	4	23	27	362.348
#491	NANOGNB	3	23	26	228.6
#492	SATB2	3	26	29	1244.106
#493	ETV5	3	25	28	420.926
#494	KCNH8	3	16	19	154.599
#495	ZNF90	3	25	28	546.058
#496	PLAG1	2	22	24	401.047
#497	ARNTL	2	26	28	399.321
#498	MSRB2	2	22	24	296.414
#499	ZIC2	1	40	41	241.313
#500	IRX4	1	24	25	47.157