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Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	E2F4	62	3	65	222.327
#2	HNF1B	56	5	61	245.61
#3	MLL	55	2	57	1598.153
#4	ZNF24	52	1	53	764.941
#5	ENO1	46	3	49	933.9
#6	USF2	44	9	53	6550.482
#7	ZNF140	44	3	47	738.211
#8	CBFA2T2	43	8	51	5435.077
#9	ZNF207	43	4	47	320.765
#10	PHF1	42	7	49	1030.368
#11	SPDEF	42	3	45	129.359
#12	CREB1	42	3	45	50.657
#13	MMP14	41	3	44	76.152
#14	KLF16	40	8	48	781.841
#15	HMGB1	40	7	47	678.455
#16	TFCP2	40	4	44	1642.083
#17	FOSL2	40	4	44	549.101
#18	YBX1	39	5	44	694.037
#19	HMG20A	39	8	47	2711.141
#20	MLX	39	7	46	781.644
#21	ZNF277	39	6	45	4105.036
#22	ZNF232	39	6	45	844.805
#23	SP1	38	2	40	142.148
#24	PAX8	38	1	39	17.834
#25	TCF7	37	2	39	1069.79
#26	ZNF236	36	3	39	34.34
#27	RARG	36	7	43	121.869
#28	CEBPB	35	3	38	463.006
#29	ZNF445	34	6	40	131.841
#30	NFIL3	34	1	35	878.914
#31	RAX2	33	6	39	109.128
#32	PRRX2	33	5	38	86.488
#33	CSRNP1	32	7	39	1048.7
#34	TAF12	31	11	42	1903.356
#35	RXRA	30	12	42	2004.441
#36	STAT5B	29	7	36	6692.288
#37	ELF1	29	2	31	5.384
#38	BRD8	29	5	34	770.223
#39	ETS2	29	3	32	491.739
#40	REST	28	6	34	845.22
#41	JDP2	28	6	34	2215.609
#42	ZNF45	28	6	34	1143.487
#43	NFYB	28	7	35	4186.91
#44	SREBF2	27	9	36	887.328
#45	RXRB	27	9	36	1580.15
#46	FOXN3	26	5	31	487.139
#47	RCOR1	26	7	33	540.815
#48	BCL11B	26	9	35	4817.782
#49	ZNF189	25	7	32	1194.681
#50	RFXAP	25	8	33	1824.607
#51	RFXANK	25	11	36	8538.386
#52	BCL6	25	9	34	1438.322
#53	TFEB	25	8	33	4427.248
#54	KLF12	25	5	30	2932.032
#55	HOXC11	25	5	30	51.984
#56	SOX21	25	5	30	1042.168
#57	NFE2	25	12	37	6755.421
#58	ATF1	25	3	28	209.857
#59	ADNP	24	5	29	2340.117
#60	STAT6	24	6	30	1689.849
#61	NR1H2	24	8	32	1167.562
#62	TCF20	23	12	35	1319.023
#63	NFYC	23	5	28	1532.354
#64	FOXO3	23	11	34	4468.111
#65	IKZF1	23	8	31	1145.784
#66	ZNF91	23	6	29	452.613
#67	SATB1	22	8	30	5254.846
#68	RELA	22	9	31	1119.415
#69	KDM5A	22	8	30	1367.771
#70	ZKSCAN1	22	10	32	4054.938
#71	TCF25	22	8	30	1447.092
#72	KLF4	22	8	30	2834.814
#73	C5orf41	21	12	33	786.526
#74	LASS6	21	11	32	5995.471
#75	PURB	21	4	25	93.337
#76	TSC22D3	21	6	27	182.807
#77	TEAD2	21	3	24	4335.04
#78	ZRANB2	21	10	31	812.565
#79	GTF2H3	20	7	27	2661.435
#80	ZBTB38	20	9	29	2933.423
#81	ZNF397	20	16	36	6363.275
#82	POU5F1B	20	8	28	80.424
#83	NR4A2	20	6	26	819.717
#84	NFKB2	20	17	37	4679.388
#85	ARID4A	20	7	27	588.226
#86	DDIT3	20	16	36	3385.161
#87	ARNTL	20	10	30	2737.214
#88	MESP1	19	9	28	124.691
#89	NR2C2	19	7	26	3514.358
#90	FLI1	19	8	27	1269.548
#91	BCL3	19	10	29	1267.863
#92	ZNF438	19	7	26	364.204
#93	AFF4	19	12	31	3601.526
#94	MTA1	19	14	33	2136.455
#95	TAF5	19	10	29	1920.124
#96	NR2C1	19	11	30	1514.756
#97	STAT1	19	7	26	171.501
#98	ZKSCAN5	19	8	27	554.169
#99	NKX1-1	19	7	26	403.816
#100	MLLT10	18	7	25	460.763
#101	CSRNP2	18	16	34	1172.064
#102	MAFF	18	6	24	485.155
#103	KLF3	18	7	25	174.955
#104	SUPT6H	18	14	32	5476.024
#105	RORA	18	7	25	3874.358
#106	MEIS3	18	11	29	141.935
#107	POU2F2	18	12	30	1532.409
#108	CEBPD	18	7	25	611.267
#109	AHCTF1	18	12	30	1093.514
#110	HIF3A	18	7	25	173.919
#111	MXD1	18	9	27	3732.294
#112	TBX21	18	15	33	1530.191
#113	L3MBTL4	18	19	37	3831.268
#114	CNOT8	18	8	26	1360.554
#115	ZNF19	17	11	28	857.568
#116	HOXB1	17	13	30	657.566
#117	FUBP1	17	7	24	2673.017
#118	NFATC4	17	7	24	1266.586
#119	STRN3	17	10	27	803.102
#120	LZTS1	17	7	24	1026.318
#121	DLX2	17	9	26	238.591
#122	MNX1	17	12	29	882.621
#123	SPEN	17	8	25	240.015
#124	RBCK1	17	13	30	7539.012
#125	CREB3L1	17	10	27	497.138
#126	MAFB	17	8	25	622.065
#127	NPAT	17	11	28	4530.351
#128	ZSCAN16	16	10	26	1852.631
#129	PRDM2	16	9	25	399.825
#130	CREBL2	16	10	26	341.555
#131	CREBZF	16	15	31	1928.887
#132	HCFC1	16	9	25	736.337
#133	TCEAL1	16	9	25	3227.39
#134	ZNF193	16	15	31	1950.906
#135	E2F6	16	9	25	4863.74
#136	SCAND1	16	16	32	5474.267
#137	RBPJ	16	11	27	5784.464
#138	CSDA	16	5	21	1274.244
#139	GSX1	16	12	28	1513.805
#140	MGA	15	7	22	783.848
#141	CREM	15	7	22	1366.138
#142	GBX1	15	10	25	271.288
#143	ZNF167	15	13	28	2055.127
#144	HMX1	15	11	26	549.249
#145	SOX6	15	12	27	5778.766
#146	GLI3	15	13	28	2954.559
#147	E2F5	15	18	33	2679.84
#148	NFIC	15	16	31	1394.22
#149	ZKSCAN4	15	7	22	1543.215
#150	FOXO1	15	18	33	3355.613
#151	ZEB2	15	12	27	1279.136
#152	KLF6	15	13	28	950.83
#153	SOX13	15	9	24	467.45
#154	MSRB2	15	10	25	1731.326
#155	ZNF434	15	17	32	2005.336
#156	CITED2	15	9	24	864.254
#157	ZFP36L2	15	10	25	437.624
#158	NFATC1	15	6	21	5847.511
#159	NCOR1	15	16	31	2314.385
#160	GATAD2A	15	9	24	949.599
#161	BLZF1	15	8	23	510.998
#162	SNAPC2	15	13	28	9288.88
#163	ATF6	14	8	22	3882.965
#164	KLF9	14	9	23	1778.159
#165	ZNF75D	14	10	24	644.735
#166	ALS2CR8	14	16	30	1184.948
#167	SLC30A9	14	14	28	601.182
#168	PKNOX2	14	9	23	1160.491
#169	SP4	14	12	26	552.015
#170	SPI1	14	12	26	769.145
#171	TFAM	14	11	25	1152.36
#172	CREB5	14	13	27	2285.469
#173	ZFP90	14	16	30	2570.858
#174	MTF1	14	13	27	1719.658
#175	IRF2	14	8	22	523.731
#176	TFDP2	14	21	35	4745.947
#177	JUND	13	12	25	1497.895
#178	NR3C2	13	12	25	1337.47
#179	TSHZ3	13	12	25	6594.889
#180	JUNB	13	10	23	214.615
#181	TFEC	13	14	27	826.598
#182	ZNF628	13	18	31	2295.927
#183	HMG20B	13	12	25	2539.358
#184	DBP	13	15	28	663.59
#185	ZFPM1	13	7	20	939.234
#186	SOX1	13	7	20	353.964
#187	GAS7	13	8	21	449.115
#188	CBFB	13	9	22	740.946
#189	GTF2H4	13	12	25	365.909
#190	EVX1	13	13	26	1354.195
#191	TFDP1	13	13	26	926.758
#192	NFAT5	13	8	21	337.667
#193	ATF7	13	12	25	2418.136
#194	BACH2	13	17	30	3828.782
#195	PHTF1	13	12	25	1463.191
#196	HOXC8	13	12	25	2490.315
#197	PCGF6	13	10	23	2435.897
#198	ELF2	13	16	29	2570.54
#199	FOSB	13	11	24	600.697
#200	SLC2A4RG	13	16	29	2652.617
#201	TCF3	12	15	27	3822.056
#202	FOS	12	13	25	395.576
#203	ZNF268	12	12	24	968.455
#204	ZNF148	12	8	20	1236.991
#205	ARX	12	6	18	428.123
#206	ZNF133	12	8	20	811.729
#207	TRIM28	12	11	23	2637.025
#208	GABPB1	12	16	28	3507.975
#209	C2orf3	12	9	21	340.021
#210	ZNF138	12	13	25	1214.959
#211	TAF5L	12	19	31	3104.656
#212	GTF2I	12	6	18	317.115
#213	HOPX	11	8	19	1042.943
#214	ATF3	11	13	24	2317.097
#215	ZHX1	11	14	25	2052.419
#216	ZNF174	11	12	23	439.254
#217	JUN	11	11	22	1708.245
#218	ZBTB48	11	18	29	1894.653
#219	POU6F1	11	8	19	673.452
#220	E2F3	11	13	24	2559.741
#221	STAT3	11	13	24	3105.714
#222	NFX1	11	12	23	1267.919
#223	TP53	11	11	22	813.892
#224	BTG2	11	7	18	1561.491
#225	ELK1	11	7	18	252.851
#226	LCOR	11	7	18	204.677
#227	HIRA	11	13	24	466.193
#228	MLXIPL	11	6	17	5900.208
#229	ZNF394	11	10	21	1383.555
#230	NFE2L2	10	12	22	5689.335
#231	ZNF639	10	13	23	3026.936
#232	DLX1	10	10	20	295.777
#233	FOXP1	10	16	26	2872.724
#234	FOXC1	10	12	22	2306.066
#235	HHEX	10	10	20	472.355
#236	ERF	10	14	24	2414.487
#237	TFAP4	10	13	23	296.203
#238	FOXO6	10	9	19	429.628
#239	HOXA9	10	17	27	2771.9
#240	ZNF281	10	16	26	4108.922
#241	HMGA1	10	14	24	2024.978
#242	ZNF83	10	14	24	3291.715
#243	SMAD3	10	9	19	1527.668
#244	XBP1	10	16	26	1363.315
#245	KLF11	10	10	20	790.127
#246	RCOR2	10	12	22	1473.843
#247	STAT4	9	15	24	2132.179
#248	C1orf85	9	12	21	1512.991
#249	ATF6B	9	9	18	910.673
#250	SMAD1	9	14	23	4692.255
#251	ZSCAN5A	9	13	22	832.391
#252	ZNF197	9	16	25	1334.688
#253	UHRF1	9	13	22	2208.17
#254	ZFHX3	9	13	22	1046.842
#255	GATAD1	9	13	22	294.128
#256	MEF2A	9	15	24	650.381
#257	MEF2C	9	13	22	8330.793
#258	TCFL5	9	16	25	1159.59
#259	BHLHE40	9	13	22	804.412
#260	SOLH	9	15	24	2535.601
#261	RERE	9	13	22	906.62
#262	PURA	9	16	25	1511.774
#263	ARID3A	9	14	23	1695.86
#264	PBX1	9	9	18	1707.956
#265	EBF1	9	14	23	5465.205
#266	CTNNB1	8	10	18	1018.531
#267	NPAS1	8	16	24	366.812
#268	FOXN2	8	11	19	2031.207
#269	PLAGL2	8	10	18	679.534
#270	MYC	8	14	22	2228.955
#271	PTTG1	8	17	25	2767.961
#272	PLAG1	8	15	23	1821.06
#273	SATB2	8	16	24	2355.547
#274	CBL	8	8	16	4656.237
#275	MEF2D	8	10	18	1332.828
#276	NR4A3	8	21	29	619.19
#277	TAL1	8	8	16	1986.862
#278	HEY1	8	13	21	1880.796
#279	PPARD	8	15	23	3833.016
#280	MAF	8	18	26	528.988
#281	TP73	8	15	23	386.845
#282	KLF10	8	13	21	3054.866
#283	GCFC1	7	14	21	1153.971
#284	KLF1	7	8	15	702.274
#285	SP3	7	16	23	1365.504
#286	ETV6	7	12	19	2501.001
#287	SOX4	7	16	23	1656.851
#288	SMAD4	7	12	19	2558.146
#289	RUNX3	7	20	27	845.604
#290	PBX2	7	10	17	607.052
#291	ZNF217	7	12	19	3753.232
#292	SPIB	7	10	17	1793.86
#293	NFE2L3	7	15	22	984.117
#294	ZNF256	7	19	26	2023.631
#295	TSHZ2	7	11	18	449.691
#296	KLF7	7	15	22	749.178
#297	NFYA	7	11	18	328.053
#298	BATF2	7	20	27	1910.75
#299	NOLC1	7	7	14	2130.249
#300	GATA1	7	11	18	1971.997
#301	CBFA2T3	7	18	25	1457.516
#302	HES6	7	13	20	2043.683
#303	ZBTB25	7	16	23	3144.74
#304	TBX1	7	19	26	1934.785
#305	ZSCAN21	7	11	18	856.249
#306	ZNF33B	7	15	22	1360.33
#307	ESR1	7	8	15	6982.486
#308	SREBF1	7	8	15	354.788
#309	IRF9	7	13	20	987.776
#310	MYBL2	7	13	20	2156.929
#311	ZNF85	7	12	19	1650.778
#312	MNT	7	10	17	594.342
#313	HNF1A	7	14	21	2452.913
#314	TSHZ1	6	17	23	841.362
#315	PA2G4	6	16	22	994.426
#316	HSF2	6	13	19	322.544
#317	ETS1	6	14	20	255.002
#318	NFATC2	6	14	20	1136.296
#319	PLSCR1	6	16	22	407.555
#320	LMO4	6	15	21	308.271
#321	RCAN1	6	20	26	7930.879
#322	SMAD2	6	17	23	3813.965
#323	ZNF93	6	10	16	3248.952
#324	ELK4	6	12	18	280.132
#325	ZNF92	6	20	26	3813.242
#326	PCGF2	6	16	22	149.349
#327	UBN1	6	13	19	463.029
#328	GABPA	6	14	20	826.839
#329	BACH1	6	11	17	305.405
#330	FOXK1	6	15	21	1803.747
#331	FBXW7	6	14	20	7327.31
#332	HSF5	6	11	17	1723.948
#333	NFIB	6	13	19	2885.729
#334	ZXDA	6	10	16	1424.274
#335	GATAD2B	6	14	20	1505.888
#336	HOXA5	6	18	24	2368.605
#337	NKX3-1	6	11	17	106.288
#338	RFX1	5	15	20	1266.651
#339	MBD1	5	14	19	231.236
#340	E2F1	5	11	16	174.974
#341	GATA3	5	10	15	729.761
#342	RB1	5	20	25	1493.103
#343	SP140	5	24	29	2128.701
#344	MITF	5	14	19	1034.76
#345	PKNOX1	5	14	19	1217.351
#346	ZNF33A	5	14	19	1264.814
#347	ZXDC	5	18	23	959.966
#348	ETV3	5	15	20	336.756
#349	FOXP3	5	8	13	4364.648
#350	ZNF41	5	15	20	442.397
#351	VDR	5	17	22	539.69
#352	ASCL2	5	14	19	2050.946
#353	TCF7L2	5	12	17	1717.297
#354	ZNF175	5	11	16	1493.843
#355	MSL3	5	13	18	609.263
#356	TAF4B	5	15	20	362.689
#357	TCF12	5	16	21	700.163
#358	TSC22D2	5	13	18	1174.569
#359	SALL2	5	11	16	437.968
#360	GTF2H2	5	11	16	356.824
#361	TULP4	5	17	22	398.981
#362	HOXA1	5	20	25	801.226
#363	CUX1	5	13	18	1459.87
#364	TRPS1	5	21	26	1281.195
#365	HMGB2	5	15	20	668.136
#366	CREBBP	5	14	19	143.252
#367	ZNF3	5	11	16	1377.238
#368	SMAD5	5	16	21	1017.675
#369	TSC22D1	5	10	15	377.066
#370	AHR	5	11	16	1571.647
#371	ZNF274	5	10	15	5336.314
#372	TARDBP	5	17	22	1381.504
#373	TRERF1	4	21	25	811.895
#374	RELB	4	13	17	137.42
#375	ZNF187	4	15	19	202.369
#376	ETV7	4	9	13	664.302
#377	C11orf9	4	9	13	714.771
#378	ZNF367	4	17	21	3036.011
#379	ARNT	4	20	24	2094.111
#380	YY1	4	17	21	2234.273
#381	EPAS1	4	15	19	982.438
#382	ZSCAN29	4	15	19	2875.52
#383	TSC22D4	4	18	22	245.192
#384	SMAD6	4	9	13	855.42
#385	BHLHE41	4	18	22	5227.998
#386	MAFG	4	15	19	2005.776
#387	ATF2	4	10	14	778.265
#388	ZSCAN2	4	14	18	1298.673
#389	FOSL1	4	13	17	524.024
#390	MEOX1	4	9	13	74.482
#391	GATA4	4	11	15	334.729
#392	ZNF500	4	20	24	1521.706
#393	ZHX2	4	17	21	1554.132
#394	ZNF202	4	12	16	516.659
#395	CNOT7	4	21	25	4576.578
#396	IRF6	4	12	16	3424.202
#397	ZNF449	4	16	20	211.719
#398	ZEB1	4	10	14	365.813
#399	CEBPA	4	19	23	693.837
#400	EGR3	4	13	17	2264.935
#401	ZNF238	4	14	18	593.31
#402	ZNF37A	3	17	20	1262.429
#403	E2F2	3	15	18	1041.186
#404	NFATC3	3	16	19	1104.807
#405	SIN3A	3	18	21	2214.681
#406	SCML1	3	10	13	670.007
#407	SOX7	3	8	11	2817.063
#408	MAX	3	16	19	267.738
#409	NR1H3	3	17	20	166.876
#410	EOMES	3	15	18	566.42
#411	TGIF1	3	18	21	1311.422
#412	TCF4	3	16	19	7687.123
#413	ATF5	3	11	14	220.326
#414	NFXL1	3	14	17	1072.505
#415	VENTX	3	16	19	1358.002
#416	ZNF396	3	14	17	1582.725
#417	HOXC4	3	22	25	1312.194
#418	SOX15	3	14	17	1957.165
#419	KCNH8	3	20	23	572.268
#420	HOXD13	3	18	21	645.704
#421	TCF15	3	14	17	338.199
#422	NR1D2	3	13	16	3789.858
#423	EGR2	3	17	20	280.452
#424	SOX10	3	12	15	233.913
#425	ZSCAN18	3	10	13	157.504
#426	EGR1	2	17	19	60.556
#427	IRF7	2	13	15	496.761
#428	MSC	2	18	20	127.557
#429	MEIS3P1	2	16	18	579.298
#430	ZNF131	2	17	19	250.84
#431	SMAD9	2	12	14	583.963
#432	ADNP2	2	13	15	1715.01
#433	SOX8	2	18	20	517.176
#434	RAX	2	17	19	33.55
#435	IKZF4	2	13	15	176.213
#436	PPARA	2	16	18	170.7
#437	LEF1	2	21	23	80.162
#438	NFIX	2	10	12	760.52
#439	KLF5	2	14	16	272.727
#440	HSF1	2	11	13	59.572
#441	MEIS1	2	12	14	744.772
#442	SIX5	2	8	10	436.436
#443	ZFP37	2	10	12	854.919
#444	HR	2	14	16	106.569
#445	TAF1B	2	12	14	303.806
#446	BATF3	2	15	17	1442.458
#447	CCRN4L	2	13	15	379.721
#448	IRF1	2	21	23	740.476
#449	MTA2	2	15	17	774.091
#450	YEATS4	2	14	16	239.507
#451	RARA	2	8	10	1907.892
#452	ETV1	2	14	16	1326.509
#453	HIC1	2	15	17	163.987
#454	THRB	2	16	18	899.961
#455	TGIF2	2	13	15	574.487
#456	FOXK2	2	13	15	163.084
#457	NR4A1	2	13	15	1339.548
#458	TRIM25	2	20	22	1357.031
#459	SNAI2	1	12	13	120.495
#460	HOXB3	1	20	21	83.511
#461	PBX4	1	15	16	356.693
#462	IRF4	1	14	15	184.139
#463	ZNF287	1	15	16	273.547
#464	RUNX1	1	13	14	106.325
#465	ZNF117	1	17	18	148.026
#466	PPARG	1	13	14	29.048
#467	KLF2	1	16	17	90.134
#468	SNAI3	1	17	18	26.534
#469	IRX3	1	12	13	68.13
#470	ZFP36L1	1	20	21	201.102
#471	STAT2	1	13	14	74.763
#472	USF1	1	14	15	714.943
#473	HMBOX1	1	19	20	3668.106
#474	KDM5B	1	13	14	31.459
#475	TCF19	1	20	21	309.966
#476	NFIA	1	19	20	114.71
#477	TP63	1	16	17	28.271
#478	FOXP4	1	20	21	1392.514
#479	ZBTB17	1	19	20	3587.138
#480	GATA2	1	14	15	367.834
#481	HOXA10	0	16	16	0
#482	ELK3	0	18	18	0
#483	ZGLP1	0	16	16	0
#484	NR2F6	0	16	16	0
#485	REL	0	16	16	0
#486	HIF1A	0	14	14	0
#487	HOXA2	0	16	16	0
#488	PRDM1	0	21	21	0
#489	GATA6	0	16	16	0
#490	MAFK	0	16	16	0
#491	SOX2	0	15	15	0
#492	MYNN	0	17	17	0
#493	HOXB2	0	13	13	0
#494	MYCL1	0	20	20	0
#495	HES1	0	19	19	0
#496	ISL2	0	14	14	0
#497	RORC	0	12	12	0
#498	IRF5	0	18	18	0
#499	RUNX2	0	16	16	0
#500	CTBP1	0	13	13	0