Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	AFF1	49	3	52	3033.904
#2	ELK3	46	5	51	1040.885
#3	ZHX2	45	1	46	626.574
#4	SOX15	41	3	44	1416.979
#5	ZNF217	40	4	44	685.483
#6	ESRRA	38	5	43	1116.929
#7	ATF2	38	3	41	155.082
#8	FOXE1	37	8	45	5156.692
#9	ZBTB38	36	3	39	628.286
#10	PLSCR1	36	6	42	3885.494
#11	ECSIT	36	3	39	464.889
#12	CREBL2	35	4	39	241.3
#13	ELF2	34	6	40	952.605
#14	CUX1	33	3	36	672.196
#15	PPARD	32	5	37	794.551
#16	MZF1	32	8	40	4048.278
#17	ETV5	32	7	39	2081.285
#18	PEG3	31	8	39	1397.325
#19	GTF2I	30	3	33	881.448
#20	TCF7L1	30	4	34	1059.571
#21	SUPT6H	30	5	35	1557.24
#22	CSDA	30	8	38	3558.97
#23	PLAG1	30	5	35	555.544
#24	ZNF500	30	1	31	137.928
#25	TBX3	29	10	39	10212.937
#26	PAX8	29	6	35	1181.627
#27	TGIF2	28	6	34	1476.042
#28	RBCK1	28	12	40	3838.699
#29	TEAD4	28	5	33	393.155
#30	HHEX	27	13	40	3507.856
#31	SALL2	27	12	39	2137.455
#32	ARID4A	27	9	36	919.736
#33	PBX1	27	11	38	4572.667
#34	NFE2L1	27	8	35	607.537
#35	GATAD1	27	5	32	2941.447
#36	ZXDC	26	7	33	843.192
#37	KLF5	26	11	37	3446.484
#38	GTF2H3	26	5	31	1909.133
#39	TCF4	26	6	32	3889.887
#40	ENO1	26	12	38	2664.012
#41	ERG	25	2	27	460.704
#42	E4F1	25	8	33	1294.034
#43	ZNF35	24	7	31	1410.53
#44	SMAD6	24	8	32	1168.212
#45	GABPA	24	0	24	0
#46	CREB1	24	5	29	984.642
#47	NKX2-1	24	13	37	2970.504
#48	ZNF219	24	11	35	2563.863
#49	AHR	24	4	28	438.594
#50	CLOCK	24	8	32	1745.927
#51	MYCL1	23	7	30	2047.85
#52	MAFB	23	17	40	6012.447
#53	RFX5	23	9	32	1446.43
#54	ELF1	23	9	32	696.011
#55	HCLS1	23	4	27	567.256
#56	SMAD4	23	7	30	756.204
#57	MNT	22	9	31	1619.094
#58	ZNF148	22	4	26	937.659
#59	ZNF189	22	14	36	2729.506
#60	CNOT8	22	10	32	902.562
#61	CBFB	22	8	30	2119.698
#62	ZEB2	21	7	28	1401.141
#63	HLF	21	9	30	779.502
#64	TFE3	21	10	31	689.034
#65	HOXB7	21	6	27	1438.98
#66	ELF3	21	10	31	2122.875
#67	MSRB2	21	14	35	2552.94
#68	HMGA2	21	5	26	753.869
#69	ATF1	20	9	29	849.456
#70	PURA	20	7	27	1325.046
#71	TCF7	20	4	24	573.075
#72	WNT5A	20	10	30	6220.113
#73	IRF9	20	5	25	2439.874
#74	RUNX1	19	6	25	435.888
#75	BHLHE41	19	11	30	2508.147
#76	MAFF	19	6	25	1444.906
#77	HOXB2	19	6	25	1220.833
#78	ZBTB48	19	6	25	828.221
#79	MAX	18	12	30	1644.005
#80	SATB1	18	12	30	4176.63
#81	SMAD1	18	8	26	2298.318
#82	REL	18	10	28	2284.837
#83	FOXO1	18	8	26	709.711
#84	RXRG	17	6	23	424.291
#85	NR2F1	17	12	29	2298.378
#86	MITF	17	8	25	1021.481
#87	HEY2	17	5	22	762.959
#88	ARNTL	17	14	31	2370.881
#89	HNRNPAB	17	12	29	1773.246
#90	TSC22D1	17	10	27	1963.337
#91	CREB3L1	17	10	27	957.233
#92	ZNF268	17	10	27	2824.445
#93	NR0B1	17	5	22	961.532
#94	IRF8	17	7	24	1255.906
#95	SIX2	16	12	28	3289.961
#96	TFDP3	16	14	30	1226.738
#97	NFIC	16	12	28	712.816
#98	HDAC1	16	8	24	878.873
#99	FOSL2	16	13	29	2156.632
#100	ZNF444	16	9	25	596.817
#101	ZNF277	16	10	26	883.759
#102	E2F3	16	7	23	807.878
#103	FOSB	16	0	16	0
#104	CITED1	16	13	29	2028.335
#105	MSX1	16	10	26	3378.966
#106	KDM5A	16	2	18	159.965
#107	AEBP1	16	15	31	2986.184
#108	RUNX3	16	7	23	582.529
#109	ATF4	15	9	24	7758.028
#110	STAT1	15	8	23	1517.584
#111	ZNF24	15	5	20	385.294
#112	HOXB1	15	12	27	1193.875
#113	ETV1	15	12	27	2798.995
#114	HOPX	15	8	23	1403.935
#115	PA2G4	15	16	31	2553.565
#116	ZFHX3	15	7	22	516.133
#117	FOS	15	3	18	83.689
#118	FOXA2	15	14	29	3394.2
#119	CEBPB	15	6	21	1650.701
#120	NFAT5	15	5	20	431.157
#121	ZNF91	15	13	28	2143.567
#122	FBXW7	15	15	30	4860.769
#123	BATF	15	13	28	1145.729
#124	ALX3	15	6	21	680.361
#125	KDM5B	15	14	29	1419.002
#126	NFYB	15	10	25	251.949
#127	LMO4	15	14	29	4944.835
#128	ARNTL2	15	8	23	1331.26
#129	TFAM	15	8	23	739.288
#130	SP1	15	12	27	825.782
#131	KLF10	15	13	28	4985.309
#132	JUNB	14	1	15	603.1
#133	TCFL5	14	13	27	787.373
#134	NFE2L3	14	10	24	1540.29
#135	TFEC	14	9	23	900.984
#136	NFX1	14	8	22	725.856
#137	ZSCAN18	14	9	23	1361.971
#138	HMGB2	14	7	21	898.178
#139	TAF5	14	12	26	1359.231
#140	GCFC1	14	6	20	1161.536
#141	FOXO3	14	13	27	1822.159
#142	HES1	14	11	25	454.818
#143	ST18	14	6	20	790.022
#144	POU6F1	14	13	27	4868.969
#145	HIF3A	14	8	22	1786.711
#146	SMAD5	13	10	23	1613
#147	NFYC	13	12	25	5962.011
#148	TCEAL1	13	9	22	389.02
#149	IRF6	13	10	23	2739.684
#150	MYT1	13	6	19	435.12
#151	EPAS1	13	10	23	545.597
#152	NR4A1	13	6	19	834.382
#153	NFIB	13	9	22	556.124
#154	TEAD3	13	10	23	1082.21
#155	TGIF1	13	10	23	1145.224
#156	PHF1	13	9	22	4861.93
#157	BTG2	13	10	23	576.1
#158	GTF2IRD1	13	13	26	1519.079
#159	TFCP2L1	13	10	23	689.639
#160	ZFP36L1	13	12	25	2792.184
#161	DMTF1	13	5	18	421.833
#162	NANOG	12	15	27	570.371
#163	CREM	12	11	23	2019.127
#164	MLLT10	12	5	17	688.623
#165	PPARG	12	10	22	3575.809
#166	TEAD1	12	6	18	1173.711
#167	KLF6	12	6	18	623.456
#168	MYT1L	12	9	21	851.908
#169	SRF	12	12	24	2375.391
#170	AFF4	12	11	23	435.123
#171	EGR2	12	5	17	169.674
#172	SUPT4H1	12	13	25	1906.613
#173	NR3C2	12	8	20	730.205
#174	ZNF167	12	12	24	3447.368
#175	BHLHE40	12	20	32	1223.949
#176	RORC	12	15	27	3377.644
#177	MLL	12	6	18	302.221
#178	HOXB5	12	5	17	524.703
#179	TBX2	12	9	21	1371.421
#180	FOSL1	11	15	26	2078.855
#181	STRN3	11	11	22	936.22
#182	NR4A2	11	4	15	903.42
#183	RB1	11	2	13	1941.06
#184	FOXF2	11	10	21	2786.841
#185	ZNF117	11	11	22	2195.535
#186	PRDM2	11	12	23	1021.33
#187	BATF3	11	14	25	664.329
#188	JUN	11	6	17	256.481
#189	IRF7	11	8	19	4848.355
#190	HOXC13	11	9	20	247.675
#191	RXRA	11	12	23	1243.777
#192	GRHL2	11	9	20	1404.335
#193	TCF7L2	11	15	26	603.039
#194	TFDP2	11	17	28	9819.84
#195	DDIT3	11	15	26	973.617
#196	SLC2A4RG	11	16	27	1157.74
#197	BACH2	11	15	26	1294.144
#198	PKNOX2	11	16	27	830.086
#199	RCAN1	11	11	22	2479.156
#200	SMAD9	11	11	22	1015.489
#201	ZNF155	11	10	21	601.996
#202	FOXN3	11	11	22	1258.862
#203	MEOX2	10	6	16	1605.752
#204	GATA2	10	11	21	1177.971
#205	GATA6	10	6	16	742.854
#206	SNAI2	10	4	14	344.765
#207	PKNOX1	10	18	28	3469.588
#208	VTN	10	12	22	1953.317
#209	BACH1	10	11	21	470.5
#210	SCML2	10	12	22	1333.149
#211	E2F5	10	10	20	1473.523
#212	ASCL1	10	5	15	925.707
#213	CTNNB1	10	14	24	604.172
#214	MTA1	10	10	20	837.127
#215	MMP14	10	10	20	1955.19
#216	MEF2C	10	16	26	3982.807
#217	PCGF2	10	13	23	771.83
#218	MAFG	10	10	20	468.076
#219	PRRX1	10	12	22	1504.268
#220	TSHZ2	10	11	21	914.536
#221	NR3C1	10	8	18	1755.088
#222	CEBPD	10	7	17	573.699
#223	HOXB6	10	2	12	490.919
#224	HOXD1	9	9	18	1388.435
#225	ATF5	9	10	19	509.158
#226	AR	9	12	21	860.671
#227	ZNF33B	9	15	24	897.837
#228	MGA	9	11	20	467.76
#229	MEIS3P1	9	14	23	1623.103
#230	HMGA1	9	12	21	684.224
#231	SOX4	9	13	22	986.353
#232	MEIS1	9	13	22	2638.209
#233	TFEB	9	13	22	985.334
#234	MYBL2	9	11	20	1853.455
#235	NFATC4	9	15	24	1452.422
#236	CREB3L2	9	7	16	749.314
#237	STAT6	9	11	20	1813.182
#238	IRF1	9	6	15	853.491
#239	TWIST1	9	9	18	2654.257
#240	HMBOX1	9	11	20	977.909
#241	LASS6	9	13	22	785.77
#242	SMAD3	9	12	21	1029.578
#243	TRIM22	9	13	22	1412.512
#244	ZNF274	9	12	21	605.418
#245	TFCP2	9	10	19	3696.462
#246	KLF4	9	8	17	816.451
#247	HSF1	9	16	25	2018.163
#248	NR4A3	8	6	14	1722.764
#249	SIX3	8	6	14	1282.154
#250	GTF2H4	8	15	23	1651.419
#251	HNF1A	8	11	19	834.424
#252	TRIM29	8	12	20	2534.486
#253	HOXD3	8	11	19	1225.331
#254	NPAS1	8	9	17	1079.222
#255	EGR1	8	7	15	193.962
#256	TRIM25	8	14	22	760.601
#257	ZNF394	8	15	23	4020.085
#258	PBX3	8	12	20	631.753
#259	NR1H3	8	14	22	1754.334
#260	SPEN	8	11	19	402.306
#261	ZNF187	8	10	18	3141.223
#262	SATB2	8	16	24	2346.322
#263	ELF4	8	12	20	1261.9
#264	ESR1	8	16	24	4205.531
#265	HNF1B	8	11	19	3936.307
#266	TSC22D2	8	14	22	707.239
#267	NPAS2	8	16	24	3391.818
#268	ETS2	8	9	17	6071.574
#269	BCL3	7	16	23	2465.837
#270	ATF3	7	9	16	476.661
#271	MYC	7	14	21	634.577
#272	NR2F6	7	12	19	370.517
#273	HSF4	7	12	19	802.099
#274	EHF	7	10	17	970.31
#275	ZFPM2	7	14	21	574.551
#276	DBP	7	15	22	2275.888
#277	PRRX2	7	16	23	658.158
#278	ARNT2	7	12	19	2847.1
#279	JUND	7	7	14	610.217
#280	EVX1	7	4	11	463.931
#281	TCF3	7	15	22	793.544
#282	FOXM1	7	9	16	595.928
#283	KLF9	7	9	16	2102.336
#284	NR2F2	7	16	23	721.278
#285	EMX1	7	7	14	121.235
#286	SPI1	7	16	23	7604.227
#287	STAT3	7	12	19	902.945
#288	ZNF83	7	10	17	816.358
#289	BNC1	7	14	21	1206.952
#290	ELK1	7	15	22	881.455
#291	FOXE3	7	10	17	806.998
#292	TARDBP	7	11	18	346.999
#293	FOXB1	7	7	14	166.384
#294	ZGPAT	7	13	20	1317.271
#295	BTAF1	7	11	18	481.693
#296	SOX18	6	10	16	230.833
#297	RARA	6	13	19	745.551
#298	ETV4	6	9	15	407.22
#299	ZNF287	6	11	17	2013
#300	PTTG1	6	12	18	3945.479
#301	SPIB	6	14	20	1320.901
#302	POU3F3	6	11	17	2758.436
#303	ZNF75D	6	12	18	3322.645
#304	DLX6	6	12	18	3170.273
#305	NR1D2	6	12	18	3066.29
#306	ZEB1	6	16	22	492.195
#307	HEY1	6	15	21	1355.446
#308	GLI3	6	17	23	1167.34
#309	IKZF1	6	6	12	130.238
#310	TFAP2B	6	11	17	1417.138
#311	BCL11B	6	11	17	1846.715
#312	ATF6	6	11	17	436.426
#313	MYCN	6	15	21	874.875
#314	FUBP1	6	19	25	1930.809
#315	XBP1	6	16	22	750.257
#316	C11orf9	6	13	19	903.006
#317	STAT4	6	13	19	1456.265
#318	TP53	6	12	18	1111.479
#319	CUX2	6	13	19	1080.327
#320	E2F1	6	17	23	1366.771
#321	CEBPA	6	16	22	2352.497
#322	TFAP2A	6	7	13	1213.58
#323	MLXIPL	6	12	18	2741.589
#324	MSX2	6	15	21	579.795
#325	HR	6	14	20	693.126
#326	ZNF215	6	11	17	337.712
#327	FOXA1	6	9	15	1001.392
#328	RUNX1T1	6	16	22	668.493
#329	HOXD9	6	10	16	404.33
#330	BCL6	6	17	23	1696.112
#331	ONECUT2	6	12	18	1747.599
#332	ESRRG	6	13	19	1136.04
#333	FOXD1	5	8	13	797.181
#334	IRX5	5	8	13	1392.67
#335	HOXA10	5	11	16	6253.49
#336	PBX2	5	12	17	704.532
#337	BARX1	5	7	12	778.434
#338	PRDM1	5	13	18	677.365
#339	REST	5	15	20	875.827
#340	POU2F3	5	7	12	329.527
#341	ATF6B	5	14	19	1127.559
#342	SCML1	5	16	21	774.043
#343	SIM1	5	10	15	2502.457
#344	SOX11	5	10	15	905.276
#345	TLX1	5	13	18	1023.134
#346	ELK4	5	11	16	1213.885
#347	VDR	5	18	23	582.575
#348	TP63	5	9	14	1196.959
#349	POU3F2	5	13	18	741.47
#350	ETV3	5	8	13	1131.574
#351	GATA3	5	14	19	404.372
#352	NKX2-8	5	13	18	553.78
#353	MEIS2	5	13	18	1214.542
#354	USF2	5	13	18	1250.759
#355	THRA	5	16	21	348.434
#356	FLI1	5	12	17	1203.012
#357	TFAP2C	5	7	12	886.037
#358	BLZF1	5	14	19	1529.486
#359	GAS7	5	10	15	854.902
#360	GATAD2A	5	17	22	1366.252
#361	ZNF232	5	10	15	2725.015
#362	HIRA	5	18	23	593.019
#363	CITED2	5	13	18	587.188
#364	MEF2D	5	7	12	1357.647
#365	ETV2	4	17	21	8018.567
#366	ZNF131	4	14	18	2185.532
#367	CTBP1	4	17	21	683.138
#368	RXRB	4	14	18	478.55
#369	SOX10	4	11	15	3215.859
#370	ZSCAN12	4	10	14	539.352
#371	PAX6	4	10	14	607.431
#372	FOXJ1	4	13	17	900.043
#373	SCAND2	4	9	13	3242.024
#374	NR2E3	4	13	17	1505.702
#375	NR1H4	4	12	16	1615.18
#376	SPDEF	4	12	16	1267.288
#377	ZFP36L2	4	21	25	1441.816
#378	BUD31	4	10	14	518.326
#379	LEF1	4	17	21	2859.732
#380	EGR3	4	8	12	127.328
#381	CBFA2T2	4	12	16	1225.045
#382	NFATC3	4	12	16	2111.313
#383	MYOD1	4	12	16	1942.338
#384	NFKB2	4	12	16	562.118
#385	NR2C1	4	12	16	2078.521
#386	ZNF3	4	12	16	3243.416
#387	NFE2	4	17	21	1879.212
#388	POU2F2	4	12	16	428.137
#389	SREBF1	4	14	18	772.999
#390	GBX1	3	13	16	1794.96
#391	FEV	3	12	15	505.16
#392	WT1	3	10	13	173.822
#393	CDX2	3	11	14	267.024
#394	TAF12	3	14	17	343.852
#395	ERF	3	14	17	1070.282
#396	TAL1	3	15	18	1132.045
#397	LMX1B	3	11	14	215.645
#398	PITX2	3	8	11	330.303
#399	HCFC1	3	12	15	860.408
#400	RAX	3	12	15	600.684
#401	SNAPC4	3	12	15	255.598
#402	SALL1	3	14	17	776.204
#403	ZHX3	3	13	16	2056.847
#404	FOXC1	3	10	13	2251.52
#405	ATOH1	3	9	12	266.905
#406	ZNF175	3	17	20	647.907
#407	HOXC10	3	11	14	229.558
#408	SOX13	3	14	17	1204.625
#409	HOXD4	3	10	13	710.466
#410	CDKN2A	3	19	22	478.345
#411	ARNT	3	12	15	1757.783
#412	KLF2	3	10	13	159.134
#413	LZTS1	3	15	18	346.368
#414	LHX5	3	7	10	1466.308
#415	FOXF1	3	13	16	827.809
#416	ZNF165	3	11	14	370.346
#417	ISL1	3	16	19	216.429
#418	PITX1	3	11	14	1147.089
#419	ZNF93	3	19	22	1105.062
#420	CSRNP3	3	15	18	1460.373
#421	HOXA1	3	8	11	103.435
#422	KLF12	2	8	10	105.796
#423	CREBBP	2	12	14	260.753
#424	NFYA	2	14	16	41.742
#425	MAFK	2	13	15	1270.582
#426	NKX2-5	2	12	14	566.567
#427	PITX3	2	14	16	273.446
#428	TBX4	2	10	12	319.826
#429	POU3F1	2	11	13	237.501
#430	NR2E1	2	19	21	435.181
#431	HOXB8	2	8	10	656.645
#432	HOXA3	2	11	13	464.07
#433	MSC	2	10	12	537.988
#434	SREBF2	2	9	11	278.44
#435	RARB	2	16	18	4311.163
#436	DMRT1	2	12	14	917.269
#437	NRL	2	15	17	2100.236
#438	EGR4	2	11	13	2719.833
#439	NFIL3	2	11	13	174.723
#440	FOXG1	2	14	16	183.511
#441	ZNF323	2	18	20	4131.68
#442	ESR2	2	11	13	2781.284
#443	ARID3A	2	15	17	1308.145
#444	ZIC1	2	11	13	671.614
#445	E2F2	2	14	16	1641.092
#446	ZBTB17	2	13	15	623.319
#447	ELF5	2	9	11	368.987
#448	CREBZF	2	14	16	313.212
#449	HOXA11	2	13	15	1220.125
#450	HEYL	2	12	14	1375.219
#451	IRF4	2	15	17	721.587
#452	MECOM	2	13	15	964.712
#453	KLF11	2	8	10	1620.03
#454	RARG	2	19	21	1770.17
#455	SOX9	2	10	12	272.451
#456	SOX5	2	11	13	259.245
#457	LHX2	2	7	9	1083.605
#458	LHX1	2	7	9	266.271
#459	NOTCH1	2	12	14	112.1
#460	RFX1	2	7	9	72.313
#461	TBR1	2	13	15	281.77
#462	TEF	2	7	9	340.907
#463	MTA2	2	15	17	717.341
#464	NKX3-1	2	11	13	1288.311
#465	TSC22D3	2	15	17	2349.228
#466	PDX1	1	11	12	696.887
#467	RORB	1	11	12	76.674
#468	HOXC8	1	8	9	101.683
#469	ZSCAN2	1	8	9	192.027
#470	IRF5	1	10	11	259.595
#471	NKX3-2	1	14	15	1487.065
#472	POU6F2	1	15	16	427.74
#473	HOXD12	1	13	14	431.155
#474	SHOX	1	11	12	140.346
#475	TP73	1	10	11	128.586
#476	NFIX	1	11	12	1573.291
#477	MAF	1	15	16	475.993
#478	STAT2	1	11	12	646.541
#479	FOXC2	1	9	10	840.84
#480	GABPB1	1	15	16	208.325
#481	ZNF174	1	8	9	586.977
#482	NR5A1	1	12	13	143.312
#483	TBX5	1	11	12	521.516
#484	HOXB3	1	10	11	572.683
#485	GBX2	0	8	8	0
#486	SIX1	0	7	7	0
#487	HOXD10	0	11	11	0
#488	GATA4	0	10	10	0
#489	RERE	0	10	10	0
#490	ALX4	0	12	12	0
#491	PAX7	0	15	15	0
#492	NFATC1	0	12	12	0
#493	NR6A1	0	9	9	0
#494	CRX	0	9	9	0
#495	FOXL1	0	9	9	0
#496	TCF25	0	13	13	0
#497	CREB5	0	6	6	0
#498	FOXN1	0	11	11	0
#499	NKX6-1	0	12	12	0
#500	HMX1	0	15	15	0