Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	TSHZ3	60	2	62	28.364
#2	GLI3	59	0	59	0
#3	DMTF1	52	0	52	0
#4	MEIS1	49	2	51	1042.087
#5	NR3C1	49	6	55	390.004
#6	PURA	45	6	51	1277.687
#7	ZNF33A	44	5	49	104.186
#8	ZNF148	40	5	45	4521.301
#9	GLIS2	40	4	44	2299.746
#10	CREBZF	40	1	41	4.732
#11	MEF2A	40	8	48	1639.055
#12	CBFA2T2	40	11	51	2046.766
#13	ZNF91	39	10	49	361.667
#14	PLAGL2	38	5	43	3018.535
#15	MTA2	37	5	42	2124.188
#16	MAX	37	7	44	1363.112
#17	ASCL2	37	8	45	17769.181
#18	ZHX1	35	9	44	254.579
#19	HIC1	35	6	41	188.656
#20	ZRANB2	35	3	38	52.883
#21	ENO1	34	8	42	1161.075
#22	MITF	34	7	41	529.953
#23	ZNF92	33	7	40	956.591
#24	ZEB1	33	8	41	1117.467
#25	TWIST1	32	10	42	300.006
#26	SOX4	32	6	38	1133.455
#27	AEBP1	32	3	35	23.594
#28	PBX1	32	8	40	3388.808
#29	MAF	31	8	39	813.329
#30	FUBP1	30	9	39	124.149
#31	MAFB	30	9	39	3397.311
#32	SOX9	30	13	43	6031.167
#33	GTF2I	30	4	34	1674.33
#34	KLF2	30	10	40	867.878
#35	ZEB2	30	5	35	170.452
#36	C2orf3	30	8	38	4640.452
#37	LCOR	29	8	37	728.837
#38	ELK3	29	9	38	1153.166
#39	ATF2	29	5	34	171.45
#40	NFE2L3	29	12	41	1678.771
#41	HMGB2	28	12	40	7812.752
#42	ZNF83	28	14	42	1676.707
#43	HMGB1	28	10	38	475.182
#44	NFYB	28	7	35	373.798
#45	ZC3H8	28	15	43	8771.998
#46	MYNN	28	7	35	162.34
#47	PITX1	28	9	37	1323.213
#48	TEAD1	27	14	41	1791.219
#49	GCFC1	27	8	35	7015.515
#50	CCRN4L	27	12	39	2399.893
#51	TCF7	27	10	37	2841.019
#52	RUNX1T1	27	9	36	718.822
#53	PEG3	27	6	33	2218.615
#54	CREB3L1	27	12	39	1830.001
#55	RORA	27	9	36	1347.37
#56	ZNF496	27	9	36	1229.946
#57	NFIC	26	18	44	1505.694
#58	OVOL1	26	9	35	1164.362
#59	IRF6	26	9	35	1346.555
#60	ZNF138	26	5	31	898.528
#61	ARID4A	26	7	33	102.627
#62	HOPX	26	9	35	110.385
#63	NFYC	26	6	32	1005.467
#64	UHRF1	26	8	34	2212.34
#65	CEBPA	25	9	34	4556.883
#66	ZNF24	25	15	40	3076.837
#67	AHCTF1	25	10	35	3227.056
#68	EPAS1	25	16	41	1533.072
#69	PHF1	25	8	33	2024.003
#70	FOXN2	25	9	34	205.964
#71	ZFPM2	25	9	34	265.312
#72	GAS7	25	6	31	78.543
#73	CDX2	24	7	31	3013.697
#74	EBF1	24	8	32	691.655
#75	CSDA	24	15	39	2704.499
#76	FOXM1	24	1	25	42.864
#77	CBL	24	6	30	508.289
#78	ETV4	23	10	33	892.67
#79	CBFB	23	10	33	964.512
#80	HOXB2	23	13	36	17289.096
#81	ZNF75D	23	11	34	934.288
#82	ZNF207	23	9	32	1242.807
#83	HCLS1	23	9	32	2465.808
#84	STAT1	23	11	34	1387.442
#85	NFATC1	23	13	36	925.124
#86	TWIST2	23	5	28	1095.284
#87	SOX17	23	9	32	612.172
#88	LASS6	23	5	28	598.366
#89	ZBTB38	22	11	33	1208.877
#90	VDR	22	7	29	5065.942
#91	ZNF33B	22	7	29	989.72
#92	NOLC1	22	7	29	3091.275
#93	FOXF1	22	6	28	1344.019
#94	TCF4	22	13	35	11264.205
#95	SNAI2	22	10	32	2415.69
#96	SPDEF	21	8	29	2823.697
#97	LMO4	21	12	33	7349.359
#98	STAT3	21	13	34	2063.988
#99	TAF4	21	8	29	391.988
#100	MEF2C	21	9	30	3413.59
#101	PRDM1	21	14	35	893.259
#102	ATF1	21	12	33	1343.9
#103	EGR3	20	12	32	1105.186
#104	ETS1	20	12	32	2980.549
#105	ARID3A	20	6	26	599.636
#106	ZFP36L2	20	15	35	1619.051
#107	ZGPAT	20	15	35	1720.842
#108	KLF9	20	17	37	1081.571
#109	FOXN3	20	15	35	1657.118
#110	C1orf85	20	15	35	2088.787
#111	ZHX2	20	14	34	2230.963
#112	IKZF1	20	4	24	56.737
#113	E2F7	20	10	30	1262.125
#114	NFAT5	20	7	27	723.03
#115	GABPA	20	6	26	72.832
#116	PRRX1	20	10	30	202.641
#117	STAT2	20	13	33	1830.837
#118	TFAM	19	15	34	2330.717
#119	HNF4G	19	15	34	1556.246
#120	SCML1	19	16	35	1414.18
#121	PTTG1	19	8	27	1942.956
#122	MEF2D	19	12	31	6014.308
#123	RUNX1	19	7	26	364.527
#124	JDP2	19	13	32	957.711
#125	TSHZ2	19	12	31	610.047
#126	FOXA3	19	14	33	3180.922
#127	NR1I2	19	16	35	1548.164
#128	CSRNP1	18	9	27	543.805
#129	ELK1	18	14	32	664.838
#130	GABPB1	18	14	32	1631.93
#131	ZFHX4	18	14	32	2162.913
#132	YEATS4	18	12	30	898.945
#133	TCF7L1	18	10	28	1031.155
#134	TEAD4	18	11	29	3571.385
#135	FLI1	18	8	26	147.999
#136	TEAD3	18	8	26	3243.504
#137	CITED2	18	15	33	1027.229
#138	GTF2IRD1	17	9	26	702.074
#139	PPARA	17	18	35	2128.635
#140	MMP14	17	14	31	788.646
#141	ETV1	17	15	32	749.665
#142	GATAD1	17	11	28	729.337
#143	MECOM	17	19	36	2251.324
#144	ZKSCAN1	17	12	29	2040.131
#145	NR2F6	17	11	28	810.467
#146	RERE	17	18	35	2022.262
#147	SP1	17	8	25	102.52
#148	TFCP2L1	16	15	31	2281.599
#149	ZNF397	16	12	28	945.285
#150	ARNTL	16	14	30	2439.18
#151	SIX5	16	13	29	852.231
#152	PRRX2	16	11	27	574.264
#153	HEYL	16	10	26	1296.411
#154	BCL6	16	12	28	319.518
#155	C5orf41	16	8	24	390.948
#156	BACH1	16	7	23	1232.151
#157	UBN1	16	6	22	463.872
#158	TEF	16	15	31	1003.719
#159	PBX3	16	9	25	147.29
#160	TSC22D1	16	14	30	559.475
#161	MSC	16	11	27	988.19
#162	SOX13	16	16	32	7890.318
#163	ZNF639	16	11	27	955.241
#164	PLSCR1	15	11	26	763.831
#165	MYBL2	15	8	23	758.755
#166	RXRA	15	16	31	1681.337
#167	HNF1B	15	14	29	1490.753
#168	TRIM22	15	17	32	1456.557
#169	RB1	15	10	25	1014.916
#170	E2F8	15	7	22	713.642
#171	ATF5	15	17	32	1567.136
#172	NR5A2	15	18	33	3250.238
#173	JUNB	15	7	22	464.631
#174	CREB3	15	13	28	292.434
#175	ESRRA	15	9	24	646.389
#176	HNF4A	15	11	26	710.538
#177	HMGA1	15	10	25	931.694
#178	TFAP2A	15	16	31	2470.206
#179	HHEX	15	22	37	1940.398
#180	RUNX2	14	10	24	738.555
#181	NKX2-3	14	8	22	1675.676
#182	NR3C2	14	19	33	2962.865
#183	SATB2	14	17	31	2112.872
#184	EGR2	14	10	24	103.659
#185	NR4A1	14	10	24	1448.619
#186	AFF4	14	13	27	1016.296
#187	ZNF277	14	14	28	1220.554
#188	ELF3	14	18	32	1955.529
#189	FOXO1	14	19	33	8354.321
#190	SP3	14	10	24	94.236
#191	TCFL5	14	11	25	1568.862
#192	TARDBP	14	13	27	653.419
#193	NKX3-1	14	15	29	6375.582
#194	HSF1	14	13	27	2080.392
#195	THRA	14	15	29	2002.347
#196	LZTS1	14	12	26	1349.687
#197	ZNF281	14	10	24	724.459
#198	FOXF2	13	11	24	538.706
#199	ZNF367	13	13	26	1073.12
#200	MLXIPL	13	19	32	2706.67
#201	TFEB	13	18	31	4247.026
#202	KLF4	13	15	28	1440.905
#203	SOLH	13	13	26	1967.784
#204	PGR	13	6	19	307.516
#205	KLF7	13	15	28	548.865
#206	NFXL1	13	14	27	2190.218
#207	RFXAP	13	19	32	1899.592
#208	TRPS1	13	13	26	3484.033
#209	CLOCK	13	18	31	1298.091
#210	SOX7	13	12	25	444.28
#211	HES6	13	13	26	1006.687
#212	SOX30	13	9	22	1143.719
#213	USF1	13	5	18	298.429
#214	KLF12	13	20	33	2118.361
#215	SLC30A9	13	23	36	1569.569
#216	ERG	13	13	26	311.642
#217	GRHL2	13	14	27	833.648
#218	TAF13	13	11	24	1953.311
#219	ZNF238	13	17	30	1230.187
#220	SMAD5	13	11	24	424.813
#221	TAF5	12	8	20	432.99
#222	ARNTL2	12	20	32	2394.687
#223	BCL11B	12	15	27	1223.246
#224	MEIS3P1	12	16	28	931.458
#225	PBX2	12	20	32	3325.301
#226	FOXO3	12	15	27	1100.765
#227	STRN3	12	15	27	964.218
#228	CBFA2T3	12	7	19	1822.627
#229	HOXD9	12	9	21	2608.048
#230	E2F5	12	13	25	696.101
#231	E2F2	12	13	25	1192.533
#232	HOXA10	12	4	16	543.669
#233	HMGA2	12	23	35	1956.694
#234	RUNX3	12	14	26	974.91
#235	TGIF2	12	12	24	1525.299
#236	KLF3	11	8	19	257.495
#237	FOXP2	11	15	26	2727.257
#238	FOXP1	11	17	28	1472.943
#239	ISX	11	22	33	3189.233
#240	RCAN1	11	13	24	5088.281
#241	ZNF174	11	16	27	1710.354
#242	ATF6	11	14	25	2930.439
#243	SPEN	11	5	16	452.786
#244	HSF2	11	12	23	1049.423
#245	CREM	11	16	27	1203.946
#246	MEOX1	11	14	25	698.146
#247	TAF4B	11	15	26	656.377
#248	MEIS2	11	15	26	756.998
#249	GLI2	11	9	20	136.334
#250	HAND1	11	9	20	1959.853
#251	CTNNB1	11	12	23	1587.887
#252	EOMES	11	17	28	2169.521
#253	NFIA	11	15	26	1054.999
#254	HEY1	11	17	28	368.788
#255	SMAD3	11	17	28	1437.258
#256	HOXB6	11	9	20	1395.578
#257	TCEAL1	11	10	21	1224.7
#258	TCF19	11	14	25	1411.18
#259	PROX1	11	17	28	1577.654
#260	CREB3L4	11	16	27	2278.106
#261	ZFP90	11	17	28	1004.907
#262	TCF21	11	12	23	295.692
#263	NOTCH1	11	17	28	1150.369
#264	SLC26A3	11	23	34	3985.648
#265	NFIX	11	11	22	886.178
#266	TAF1B	10	13	23	552.473
#267	FOXO6	10	17	27	1436.41
#268	NR2F2	10	10	20	593.028
#269	SIN3A	10	17	27	824.983
#270	HOXA3	10	8	18	1052.737
#271	MLL	10	19	29	1605.74
#272	TCF12	10	14	24	673.636
#273	GATA3	10	13	23	263.15
#274	MBD1	10	16	26	2331.19
#275	MLX	10	14	24	1142.152
#276	IRF7	10	17	27	1765.686
#277	SALL1	10	19	29	2051.475
#278	ETV5	10	20	30	1206.13
#279	NPAT	10	14	24	134.423
#280	CREB1	10	12	22	538.184
#281	SATB1	10	22	32	1451.365
#282	GATA4	10	5	15	484.76
#283	PCGF6	10	14	24	1081.474
#284	MLLT10	10	12	22	433.328
#285	ZXDA	10	16	26	971.407
#286	JUN	10	16	26	1288.508
#287	NFIB	10	23	33	1549.164
#288	ZNF131	10	11	21	335.258
#289	SALL2	10	7	17	904.272
#290	RORC	10	20	30	1934.949
#291	TSHZ1	10	17	27	1443.76
#292	VTN	10	5	15	552.67
#293	GTF2H2	10	14	24	1651.246
#294	SCAND1	9	12	21	1038.556
#295	ZSCAN18	9	19	28	387.227
#296	NR4A3	9	17	26	451.332
#297	FOXJ3	9	13	22	2390.089
#298	KLF16	9	14	23	1973.8
#299	AHR	9	11	20	560.349
#300	TULP4	9	12	21	399.525
#301	FOXP4	9	16	25	1033.266
#302	HOXB4	9	9	18	1400.743
#303	ZNF268	9	16	25	653.648
#304	FOXQ1	9	19	28	518.45
#305	FOXL1	9	15	24	4280.496
#306	HOXB3	9	13	22	966.588
#307	MSRB2	9	19	28	832.968
#308	FOXA2	9	16	25	920.94
#309	CNOT7	9	13	22	213.147
#310	MYC	9	13	22	2163.255
#311	NKX3-2	9	17	26	1578.912
#312	MTA1	9	16	25	1086.161
#313	HLF	9	14	23	461.554
#314	SIX1	9	11	20	2415.485
#315	RELB	9	22	31	592.95
#316	MXD1	9	13	22	784.138
#317	ZNF274	9	15	24	1434.659
#318	PPARD	9	18	27	528.942
#319	IRF1	8	12	20	1072.791
#320	HOXD1	8	18	26	1047.021
#321	FOXC2	8	17	25	1741.253
#322	HOXA11	8	7	15	448.708
#323	FOSL2	8	16	24	1884.566
#324	TSC22D3	8	17	25	268.937
#325	MAFF	8	11	19	562.827
#326	SLC2A4RG	8	19	27	1701.178
#327	ZNF117	8	13	21	322.635
#328	IRF9	8	9	17	228.932
#329	KDM5A	8	17	25	709.95
#330	NR1D2	8	17	25	1405.778
#331	ZNF187	8	19	27	605.469
#332	NPAS2	8	23	31	541.03
#333	LEF1	8	16	24	1216.142
#334	C11orf9	8	23	31	1411.034
#335	GATA2	8	15	23	910.988
#336	TBX2	8	12	20	385.706
#337	GATAD2B	8	18	26	2893.252
#338	ZNF41	8	18	26	767.355
#339	ISL1	8	20	28	1081.469
#340	YY1	8	11	19	912.816
#341	BATF2	8	18	26	1160.211
#342	ERF	8	21	29	1127.631
#343	TFDP2	8	18	26	1120.03
#344	HOXB7	8	11	19	282.009
#345	NR2C1	7	13	20	237.7
#346	MESP1	7	18	25	1302.06
#347	HOXB5	7	14	21	515.286
#348	NFX1	7	17	24	616.402
#349	SREBF1	7	21	28	4228.641
#350	HOXD8	7	15	22	996.774
#351	NR1H4	7	14	21	638.033
#352	HOXA1	7	16	23	1692.51
#353	XBP1	7	18	25	550.133
#354	ZSCAN2	7	16	23	673.901
#355	ZNF71	7	16	23	485.871
#356	NR1H3	7	16	23	1968.963
#357	SUPT4H1	7	20	27	1055.513
#358	ZNF215	7	16	23	3197.946
#359	BLZF1	7	12	19	263.895
#360	TAF5L	7	9	16	986.203
#361	ELF1	7	18	25	1157.446
#362	CEBPD	7	18	25	987.775
#363	ZNF323	7	16	23	1316.599
#364	ZFP36L1	7	20	27	803.731
#365	BHLHE40	7	23	30	768.719
#366	ETV6	7	14	21	943.972
#367	E2F3	7	21	28	673.787
#368	KDM5B	7	15	22	563.092
#369	ONECUT2	7	23	30	2171.465
#370	SOX12	7	20	27	2213.037
#371	ZNF93	7	24	31	1715.127
#372	MGA	7	12	19	531.661
#373	SMAD4	7	18	25	1416.495
#374	SIX4	7	11	18	3108.309
#375	EHF	7	14	21	689.804
#376	EGR1	7	18	25	815.304
#377	NR2F1	6	18	24	726.966
#378	KLF5	6	16	22	581.836
#379	STAT4	6	11	17	1788.86
#380	MYCL1	6	13	19	1093.056
#381	DBP	6	20	26	1168.562
#382	FOXC1	6	23	29	733.167
#383	NR4A2	6	13	19	987.233
#384	FOS	6	14	20	253.248
#385	ZNF133	6	13	19	501.088
#386	HEY2	6	19	25	353.668
#387	HOXA7	6	12	18	1332.095
#388	ZIC2	6	27	33	2724.207
#389	SOX11	6	15	21	887.828
#390	CREBL2	6	17	23	452.519
#391	ESRRG	6	16	22	986.711
#392	ZNF449	6	10	16	139.739
#393	POU2F3	6	16	22	920.184
#394	SOX2	6	18	24	2304.234
#395	PRDM2	6	18	24	2493.926
#396	SMAD9	6	25	31	5111.48
#397	TRIM29	6	23	29	1046.596
#398	HOXA9	6	9	15	677.111
#399	SMAD2	6	14	20	324.202
#400	PURB	5	13	18	225.366
#401	DLX6	5	18	23	1204.946
#402	SPIB	5	19	24	886.37
#403	TBX3	5	20	25	1819.419
#404	IRF4	5	10	15	779.452
#405	TFDP1	5	18	23	357.805
#406	THRB	5	18	23	442.783
#407	KLF6	5	14	19	1284.389
#408	IRF8	5	17	22	350.04
#409	HOXA5	5	15	20	1146.73
#410	MEOX2	5	10	15	690.026
#411	CITED1	5	13	18	702.235
#412	KCNH8	5	14	19	510.021
#413	SOX8	5	16	21	589.329
#414	RARB	5	14	19	554.825
#415	PAX6	5	15	20	498.95
#416	ZFHX3	5	15	20	1602.758
#417	SOX1	5	16	21	736.496
#418	PCGF2	5	19	24	2068.148
#419	IRF5	5	12	17	299.792
#420	MSX1	5	22	27	335.579
#421	SIM2	5	18	23	730.771
#422	NFE2L2	5	14	19	556.451
#423	ELF4	5	12	17	183.19
#424	HOXB13	5	23	28	1678.799
#425	KLF11	5	14	19	1055.26
#426	PPARG	5	18	23	405.215
#427	CDKN2A	5	17	22	551.27
#428	FOSL1	5	21	26	657.201
#429	ELF5	4	16	20	986.029
#430	ARNT	4	17	21	1012.129
#431	BCL3	4	13	17	232.605
#432	ETS2	4	19	23	292.154
#433	TBX10	4	17	21	248.09
#434	NFATC2	4	20	24	607.809
#435	HOXB9	4	12	16	772.886
#436	NR1I3	4	4	8	566.551
#437	HES1	4	20	24	1195.153
#438	FOXA1	4	23	27	2785.088
#439	BHLHE41	4	20	24	471.766
#440	WT1	4	26	30	3723.585
#441	FOXD1	4	24	28	525.679
#442	DMRT1	4	2	6	25.514
#443	RARA	4	14	18	647.696
#444	CSRNP3	4	17	21	2430.979
#445	NFYA	4	21	25	2402.634
#446	SREBF2	4	15	19	240.058
#447	HOXD10	4	18	22	616.293
#448	FOXD2	4	15	19	925.114
#449	FOXS1	4	14	18	1378.071
#450	ATF3	4	18	22	2169.215
#451	GLIS3	4	18	22	128.633
#452	ZNF134	4	17	21	410.973
#453	HR	4	22	26	965.923
#454	IRX3	3	19	22	312.461
#455	TRERF1	3	19	22	434.536
#456	FOSB	3	19	22	467.084
#457	SIX3	3	7	10	171.571
#458	MSX2	3	27	30	1362.793
#459	ZNF165	3	16	19	516.76
#460	SOX6	3	22	25	1692.676
#461	IRX2	3	19	22	432.654
#462	BATF	3	18	21	185.653
#463	ATOH1	3	17	20	643.936
#464	TCF7L2	3	17	20	307.691
#465	HOXD13	3	23	26	595.082
#466	TP53	3	15	18	328.484
#467	ZNF45	3	20	23	243.539
#468	RXRB	3	22	25	469.466
#469	TFEC	3	19	22	2469.275
#470	ARNT2	3	18	21	1196.095
#471	MYCN	3	16	19	574.073
#472	PAX7	3	3	6	246.209
#473	HOXA2	3	15	18	612.89
#474	CREB3L2	3	12	15	505.075
#475	HOXD11	3	8	11	580.192
#476	PITX2	3	21	24	3351.095
#477	HOXB8	2	18	20	198.576
#478	HOXA13	2	19	21	189.894
#479	EN2	2	14	16	336.979
#480	TRIM25	2	20	22	557.212
#481	WNT5A	2	22	24	115.638
#482	PLAG1	2	18	20	108.722
#483	TEAD2	2	25	27	468.464
#484	BTG2	2	17	19	1651.053
#485	L3MBTL4	2	17	19	182.07
#486	DDIT3	2	13	15	252.021
#487	TGIF1	2	14	16	57.321
#488	FOXG1	2	15	17	2279.772
#489	MKX	2	12	14	435.378
#490	ZNF70	2	13	15	71.596
#491	RBCK1	2	25	27	717.688
#492	HMBOX1	2	22	24	828.447
#493	TFAP2C	1	24	25	82.209
#494	ZNF256	1	24	25	218.277
#495	DMRT2	1	27	28	196.899
#496	ETV7	1	17	18	575.469
#497	GRHL3	1	14	15	97.016
#498	ZNF85	0	15	15	0
#499	CTBP1	0	18	18	0
#500	CREB5	0	21	21	0