Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	PTTG1	74	4	78	1330.18
#2	XBP1	70	2	72	5774.792
#3	FOS	63	1	64	33.556
#4	FOSL1	63	8	71	2450.96
#5	MAFB	61	3	64	182.547
#6	AEBP1	55	5	60	109.364
#7	NFATC4	54	6	60	173.38
#8	EGR1	53	4	57	280.7
#9	ENO1	53	11	64	5199.865
#10	FOXM1	52	7	59	569.911
#11	MAF	52	9	61	436.516
#12	HOXB2	46	4	50	2282.769
#13	TCF4	45	4	49	1148.055
#14	TBX3	43	10	53	986.12
#15	MECOM	41	13	54	528.382
#16	JUNB	40	5	45	5448.112
#17	NR4A1	40	8	48	592.904
#18	HCLS1	40	7	47	760.931
#19	FOXA1	40	4	44	144.049
#20	E2F8	40	3	43	31.953
#21	E2F1	39	12	51	2593.995
#22	TRPS1	39	9	48	632.386
#23	HMGA1	38	13	51	2762.553
#24	BCL6	37	11	48	1463.77
#25	TAF5	36	5	41	56.748
#26	IRF6	36	5	41	129.338
#27	SPDEF	36	8	44	2583.212
#28	HMGA2	35	4	39	36.723
#29	TFE3	35	11	46	896.57
#30	ESR1	35	8	43	568.46
#31	E2F3	34	6	40	416.933
#32	TRIM22	34	9	43	594.114
#33	TFAM	34	14	48	4462.938
#34	SMAD3	34	13	47	593.065
#35	LASS6	34	13	47	982.39
#36	IRX5	33	15	48	1121.869
#37	PPARG	33	14	47	1211.599
#38	AR	33	5	38	419.914
#39	ZNF83	33	14	47	2921.93
#40	PRRX1	32	4	36	40.688
#41	REXO4	32	12	44	20069.945
#42	ELF3	32	4	36	922.784
#43	YEATS4	32	8	40	2418.096
#44	ZNF45	32	12	44	3357.642
#45	IRF9	32	7	39	231.569
#46	ZEB1	31	14	45	476.157
#47	RUNX3	30	14	44	768.975
#48	SMAD5	30	7	37	194.56
#49	GATA3	29	8	37	7795.6
#50	HOPX	29	11	40	296.277
#51	HOXA5	28	9	37	1821.86
#52	TRIM29	28	13	41	716.795
#53	SOX4	28	11	39	475.184
#54	TCF12	28	15	43	12344.884
#55	TEAD1	28	6	34	479.473
#56	RXRB	28	13	41	1776.814
#57	TFAP2A	28	9	37	2974.541
#58	HOXC4	27	6	33	185.16
#59	ETV1	27	9	36	148.934
#60	ZNF215	27	8	35	240.918
#61	ETS1	27	14	41	996.089
#62	NFIC	27	12	39	1354.512
#63	FOXF2	26	9	35	490.261
#64	EN1	26	14	40	2021.958
#65	NFE2L3	26	13	39	439.807
#66	CDKN2A	26	12	38	1417.667
#67	HR	25	19	44	2389.958
#68	ARNTL2	25	11	36	1227.725
#69	HDAC2	25	10	35	573.839
#70	ZFP36L1	25	14	39	1651.995
#71	EGR2	24	10	34	224.981
#72	TCF7L1	24	11	35	1273.184
#73	CEBPA	24	13	37	979.73
#74	MEF2C	23	14	37	584.016
#75	ETV5	23	15	38	689.645
#76	HES1	23	13	36	515.969
#77	ZHX2	23	11	34	390.968
#78	FOXC1	22	8	30	1030.779
#79	SATB2	22	16	38	576.215
#80	PLSCR1	22	7	29	341.99
#81	SCML1	22	13	35	536.352
#82	NR3C1	22	14	36	7487.407
#83	ZNF175	22	10	32	909.586
#84	PCGF2	22	12	34	726.128
#85	DLX4	22	14	36	6355.969
#86	MSX1	21	12	33	208.282
#87	SOX10	21	12	33	2463.438
#88	ZNF134	20	14	34	1336.77
#89	ZFP36L2	20	17	37	1215.889
#90	MGA	20	8	28	276.187
#91	ATF1	20	9	29	566.115
#92	NKX3-1	20	9	29	565.142
#93	IRF7	20	8	28	754.459
#94	HMBOX1	20	12	32	305.951
#95	CEBPD	20	7	27	350.54
#96	HSF1	20	13	33	1135.704
#97	NFYA	20	15	35	1025.118
#98	MAFF	20	13	33	266.727
#99	MEOX1	20	15	35	681.162
#100	LMO4	20	7	27	513.147
#101	HOXC10	19	8	27	322.993
#102	TP53	19	17	36	4631.312
#103	STAT1	19	11	30	340.819
#104	GLI3	19	6	25	135.145
#105	ZNF24	19	16	35	1142.592
#106	TFEC	19	9	28	439.771
#107	FOXA2	19	4	23	25.251
#108	ERG	19	12	31	243.981
#109	MEIS1	18	11	29	237.064
#110	ECSIT	18	12	30	403.313
#111	HSF4	18	15	33	1237.958
#112	BATF	18	16	34	1008.726
#113	SRF	18	12	30	3382.936
#114	GAS7	18	9	27	669.073
#115	JUND	17	15	32	2046.248
#116	CBFA2T2	17	11	28	194.856
#117	HINFP	17	17	34	16127.998
#118	NFIX	17	15	32	1760.37
#119	GATA6	17	18	35	1488.259
#120	HLF	17	20	37	2171.482
#121	HIF1A	17	7	24	168.514
#122	TBX19	17	16	33	529.77
#123	TSC22D3	17	14	31	273.792
#124	HOXD3	17	12	29	1391.212
#125	SOX9	17	16	33	3687.422
#126	FOXG1	17	14	31	2281.828
#127	NRL	17	13	30	1269.076
#128	GRHL2	16	7	23	206.763
#129	C2orf3	16	14	30	369.288
#130	FOXP3	16	11	27	2026.466
#131	HOXA9	16	11	27	246.131
#132	GABPA	16	14	30	1402.211
#133	ZNF91	16	12	28	279.548
#134	RUNX2	16	14	30	2392.247
#135	HEY1	16	15	31	930.463
#136	BHLHE40	16	13	29	881.482
#137	NFX1	15	14	29	321.793
#138	TWIST1	15	14	29	333.8
#139	TAF1B	15	11	26	330.204
#140	CREB3L1	15	15	30	1144.115
#141	NKX2-5	15	14	29	1874.498
#142	ZXDC	15	14	29	272.052
#143	KLF4	15	15	30	1249.102
#144	CSDA	15	10	25	646.409
#145	ZNF135	15	14	29	267.393
#146	BTG2	15	6	21	126.569
#147	ATF3	15	9	24	375.019
#148	HEY2	15	11	26	218.525
#149	SPI1	15	9	24	1127
#150	KLF5	15	14	29	2054.831
#151	TCF15	15	11	26	1979.208
#152	HSF2	15	17	32	2091.286
#153	TRIM25	15	13	28	1617.268
#154	TFAP2B	14	18	32	617.106
#155	PLAG1	14	13	27	276.658
#156	RUNX1T1	14	10	24	1069.482
#157	EGR3	14	9	23	168.272
#158	MYCN	14	17	31	1134.146
#159	MLLT10	14	14	28	1404.955
#160	NKX3-2	14	15	29	420.252
#161	ZBTB48	14	13	27	733.34
#162	SMAD1	14	13	27	966.016
#163	SOX18	14	15	29	561.742
#164	SPEN	14	14	28	2159.711
#165	MSRB2	14	13	27	2592.188
#166	THRA	14	13	27	508.287
#167	SNAPC5	14	14	28	2995.963
#168	ATF6B	14	13	27	845.334
#169	RXRG	14	17	31	3365.845
#170	ZNF643	14	19	33	2224.047
#171	TFCP2L1	14	12	26	555.46
#172	TP63	13	18	31	1490.993
#173	NFATC3	13	15	28	8864.464
#174	SCRT1	13	14	27	4366.859
#175	ONECUT2	13	13	26	623.6
#176	TCEAL1	13	12	25	1843.019
#177	BCL11B	13	7	20	615.528
#178	POU5F1B	13	19	32	3388.73
#179	BHLHE41	13	18	31	491.733
#180	AHR	13	14	27	1386.644
#181	PBX1	13	13	26	509.021
#182	TBX6	13	14	27	1006.85
#183	ATF7	12	14	26	2105.106
#184	TBX10	12	11	23	1060.634
#185	TFEB	12	13	25	895.463
#186	HNF1B	12	15	27	1803.78
#187	USF2	12	17	29	2141.369
#188	WNT5A	12	15	27	1158.161
#189	MMP14	12	19	31	627.193
#190	CBFA2T3	12	9	21	333.686
#191	SOX17	12	14	26	951.19
#192	TLX1	12	18	30	1255.605
#193	RARA	12	16	28	557.787
#194	ZFPM2	12	12	24	1376.24
#195	NANOG	12	9	21	704.543
#196	GATA2	12	15	27	1618.295
#197	PRRX2	12	11	23	564.576
#198	SNAI2	12	15	27	1215.123
#199	ZFHX3	12	18	30	1969.98
#200	SP1	12	18	30	1498.55
#201	FLI1	12	16	28	795.556
#202	ELK1	12	14	26	969.367
#203	IRF8	12	9	21	458.595
#204	NR1I2	12	12	24	880.24
#205	SOX30	11	19	30	1379.926
#206	NR2F1	11	14	25	918.57
#207	PAX6	11	15	26	2401.539
#208	POU3F3	11	13	24	795.085
#209	HOXD9	11	15	26	2418.714
#210	ATF6	11	14	25	1111.456
#211	ELF4	11	16	27	208.457
#212	ZGPAT	11	9	20	584.45
#213	CLOCK	11	10	21	1724.875
#214	POU4F1	11	15	26	1215.031
#215	ETV4	11	14	25	249.582
#216	NR4A3	11	17	28	1217.026
#217	BATF3	11	12	23	844.629
#218	HNF4A	11	14	25	883.515
#219	NR3C2	11	19	30	609.953
#220	HNF1A	11	11	22	690.972
#221	C11orf9	11	15	26	1993.804
#222	HIF3A	11	11	22	2562.047
#223	E2F2	11	10	21	1233.64
#224	NFKB2	11	14	25	1147.873
#225	REST	11	18	29	1585.076
#226	PAX8	11	10	21	307.563
#227	TEAD4	11	13	24	1563.718
#228	ZNF236	11	13	24	970.455
#229	PPARD	11	14	25	770.201
#230	ZHX3	11	11	22	1086.276
#231	PITX1	11	16	27	962.321
#232	FOXJ1	10	11	21	791.867
#233	MEF2A	10	17	27	1665.2
#234	HIRA	10	17	27	1922.835
#235	BCL3	10	17	27	820.092
#236	ELF5	10	8	18	501.071
#237	SOX13	10	12	22	977.537
#238	NFE2	10	14	24	332.069
#239	NR2F2	10	20	30	1004.246
#240	ZNF202	10	14	24	737.685
#241	FOXO4	10	18	28	2588.642
#242	RAX	10	14	24	1348.374
#243	SLC26A3	10	15	25	350.991
#244	SIX2	10	11	21	1660.461
#245	NR2F6	10	13	23	959.045
#246	FOSB	10	7	17	349.386
#247	HOXC5	10	12	22	259.769
#248	TFAP4	10	15	25	1926.184
#249	ZNF238	10	22	32	2117.206
#250	ZNF140	10	15	25	2769.044
#251	SIM2	10	16	26	948.396
#252	BNC1	10	12	22	425.457
#253	ISL1	10	15	25	702.064
#254	HAND1	10	12	22	1168.235
#255	SREBF1	10	10	20	2203.661
#256	ONECUT1	10	20	30	1643.757
#257	ARID3A	10	14	24	595.517
#258	ZEB2	10	8	18	271.315
#259	ESR2	10	18	28	2874.419
#260	ZKSCAN1	10	14	24	338.367
#261	ZNF500	10	9	19	1331.474
#262	SOX21	10	16	26	2272.234
#263	SP140	10	15	25	932.427
#264	HEYL	10	13	23	1749.923
#265	LHX6	9	17	26	1680.153
#266	PAX4	9	15	24	1562.113
#267	ZNF155	9	18	27	1118.099
#268	GLI2	9	12	21	1298.832
#269	SOX15	9	13	22	2150.416
#270	CEBPE	9	10	19	1452.838
#271	PEG3	9	19	28	1848.538
#272	KLF9	9	17	26	3699.88
#273	NR0B1	9	20	29	1377.057
#274	LMX1B	9	16	25	693.974
#275	HOXB6	9	10	19	1351.724
#276	CITED2	9	13	22	556.359
#277	GABPB1	9	9	18	360.435
#278	ZNF3	9	12	21	1442.767
#279	ZSCAN16	9	16	25	742.211
#280	RARG	9	12	21	564.774
#281	STAT6	9	12	21	1323.002
#282	PGR	9	14	23	228.153
#283	IKZF1	9	14	23	572.086
#284	HOXA1	9	13	22	1352.711
#285	ELK4	9	12	21	184.447
#286	TEF	9	15	24	1008.828
#287	GCM1	9	13	22	2040.245
#288	NEUROG1	9	15	24	1850.665
#289	MEOX2	9	16	25	482.301
#290	FOXB1	9	8	17	963.592
#291	DMRT1	9	19	28	1811.992
#292	PPARA	9	17	26	979.796
#293	HMX1	9	17	26	2849.481
#294	FUBP1	9	16	25	901.197
#295	TCF7	9	14	23	1092.663
#296	MLL	9	15	24	388.256
#297	FOSL2	9	18	27	1810.687
#298	TP73	9	10	19	879.992
#299	HOXD1	9	15	24	1525.4
#300	SOX11	9	15	24	230.247
#301	PPBPL2	9	14	23	926.491
#302	HOXD4	8	14	22	2650.751
#303	NPAS2	8	12	20	175.531
#304	HOXB3	8	11	19	122.653
#305	BUD31	8	21	29	1669.883
#306	AFF1	8	16	24	1375.587
#307	MYBL2	8	14	22	264.859
#308	HESX1	8	19	27	1477.206
#309	RCAN1	8	18	26	1004.217
#310	SPIB	8	17	25	709.577
#311	IKZF3	8	13	21	1449.504
#312	OVOL1	8	18	26	1999.514
#313	IRX4	8	22	30	1739.839
#314	ARNT	8	20	28	2540.029
#315	HOXA2	8	16	24	3083.223
#316	ARNTL	8	18	26	1230.758
#317	EHF	8	19	27	1206.747
#318	NFIL3	8	10	18	628.786
#319	CRX	8	13	21	551.252
#320	ZNF117	8	12	20	981.082
#321	TADA2A	8	12	20	728.55
#322	MBD1	8	15	23	1135.199
#323	VAX2	8	16	24	1351.321
#324	MAX	8	16	24	575.222
#325	SATB1	8	18	26	948.187
#326	HOXA11	8	18	26	1493.658
#327	NFIB	8	14	22	398.997
#328	ZNF157	8	12	20	1308.739
#329	ZSCAN18	8	16	24	973.478
#330	MYCL1	8	14	22	650.67
#331	HOXC11	8	6	14	362.716
#332	NR6A1	8	14	22	1095.606
#333	HOXD11	8	17	25	2383.829
#334	MZF1	8	12	20	305.29
#335	SIX1	8	17	25	381.942
#336	HOXC8	7	17	24	1111.391
#337	POU3F2	7	17	24	1635.175
#338	NFATC1	7	14	21	694.44
#339	MSC	7	13	20	492.351
#340	TLX2	7	17	24	443.847
#341	ETV2	7	15	22	1102.667
#342	MAFK	7	15	22	571.015
#343	SCAND2	7	18	25	1129.367
#344	TCF7L2	7	18	25	1183.732
#345	POU2F2	7	16	23	562.729
#346	HOXA4	7	11	18	4619.36
#347	MYT1L	7	20	27	1757.544
#348	ATOH1	7	14	21	801.515
#349	VSX1	7	13	20	427.926
#350	SOX2	7	16	23	449.297
#351	TBX5	7	15	22	1303.044
#352	VDR	7	14	21	3145.141
#353	FOXI1	7	15	22	1512.449
#354	KLF12	7	14	21	732.052
#355	ZNF41	7	18	25	1265.642
#356	ST18	7	16	23	970.783
#357	POU3F4	7	12	19	517.993
#358	ZNF446	7	9	16	7968.776
#359	RORA	7	11	18	165.212
#360	JUN	7	19	26	824.08
#361	TBX2	7	18	25	357.848
#362	NR2C1	7	16	23	998.503
#363	FOXD1	7	13	20	1060
#364	MNX1	7	14	21	840.8
#365	NR5A1	7	17	24	1643.746
#366	MTA2	7	15	22	1685.215
#367	NR2E1	7	15	22	768.794
#368	PRDM1	7	12	19	142.845
#369	OLIG2	7	13	20	931.632
#370	NFAT5	7	18	25	1921.723
#371	HOXA7	7	15	22	924.03
#372	GSC2	7	15	22	1769.887
#373	NR4A2	7	12	19	106.382
#374	CITED1	7	16	23	718.413
#375	GATA1	7	14	21	715.498
#376	FOXH1	6	15	21	843.061
#377	HNF4G	6	17	23	925.125
#378	STAT2	6	11	17	140.677
#379	T	6	20	26	1390.949
#380	TBX1	6	16	22	2322.356
#381	POU4F3	6	14	20	519.677
#382	TAF13	6	16	22	2369.993
#383	POU2F3	6	12	18	709.379
#384	REL	6	9	15	808.483
#385	DLX2	6	19	25	644.512
#386	RORC	6	16	22	1833.218
#387	ZIC1	6	15	21	353.936
#388	HOXA3	6	16	22	524.834
#389	GBX2	6	10	16	570.45
#390	ZIC3	6	19	25	2187.675
#391	TCF3	6	11	17	1253.58
#392	PAX3	6	12	18	20096.28
#393	TFAP2C	6	11	17	712.709
#394	SIX3	6	10	16	1114.041
#395	MXD1	6	14	20	889.662
#396	VENTX	6	19	25	1173.555
#397	PAX5	6	12	18	3949.8
#398	TLX3	6	16	22	7468.774
#399	PDX1	6	16	22	967.144
#400	RFX3	6	16	22	1452.477
#401	FOXC2	6	19	25	1112.27
#402	SNAPC4	6	22	28	819.807
#403	ARNT2	6	17	23	689.812
#404	HOXB7	6	14	20	1244.723
#405	LZTS1	6	16	22	272.046
#406	POU6F1	6	12	18	218.876
#407	SRY	6	18	24	1876.241
#408	EMX1	6	11	17	589.713
#409	BLZF1	5	18	23	692.344
#410	ZNF174	5	19	24	1659.869
#411	LHX2	5	23	28	1015.521
#412	ZNF444	5	14	19	912.317
#413	FOXO3	5	14	19	535.351
#414	SIM1	5	15	20	619.172
#415	NEUROD1	5	17	22	1142.313
#416	TSHZ2	5	16	21	610.456
#417	TAF12	5	13	18	557.974
#418	FOXL2	5	12	17	934.312
#419	ASCL2	5	20	25	996.131
#420	HOXA10	5	11	16	270.408
#421	CUX2	5	19	24	1940.472
#422	DBP	5	15	20	738.525
#423	NR1H4	5	13	18	613.26
#424	MYC	5	13	18	204.911
#425	HOXD13	5	15	20	646.853
#426	TAL1	5	16	21	625.188
#427	ZNF287	5	19	24	5669.226
#428	E2F5	5	18	23	1839.487
#429	FOXD3	5	17	22	713.605
#430	ASCL1	5	16	21	1450.213
#431	PKNOX2	5	13	18	682.274
#432	NKX2-1	5	17	22	599.72
#433	RB1	5	15	20	967.258
#434	TSC22D2	5	11	16	489.954
#435	MYF6	5	13	18	5668.058
#436	ATF5	5	14	19	975.074
#437	KLF15	5	13	18	846.538
#438	LHX1	5	13	18	900.467
#439	ZNF268	5	14	19	726.736
#440	ZNF81	5	18	23	1062.403
#441	TFDP2	5	11	16	469.134
#442	WT1	5	21	26	572.254
#443	ZSCAN2	5	13	18	550.565
#444	BRD8	5	14	19	758.756
#445	NR5A2	4	21	25	674.508
#446	HOXB9	4	15	19	578.034
#447	FOXD2	4	11	15	603.483
#448	PTH	4	16	20	386.312
#449	ZNF80	4	16	20	709.784
#450	ZFP37	4	16	20	1357.194
#451	RUNX1	4	17	21	689.135
#452	PITX2	4	18	22	841.411
#453	RARB	4	13	17	285.375
#454	MYT1	4	16	20	993.426
#455	BARX1	4	18	22	457.358
#456	ZNF132	4	16	20	868.301
#457	STRN3	4	17	21	1059.505
#458	EN2	4	12	16	671.596
#459	PRDM2	4	17	21	560.918
#460	HOXC13	4	18	22	123.872
#461	MYF5	4	16	20	288.393
#462	HOXB1	4	13	17	722.997
#463	CREBZF	4	14	18	305.913
#464	RERE	4	15	19	369.004
#465	HIC1	4	16	20	277.989
#466	CSRNP3	3	19	22	1157.013
#467	PROX1	3	16	19	308.009
#468	DLX6	3	17	20	413.167
#469	ZNF434	3	18	21	580.214
#470	NPAT	3	16	19	366.927
#471	NKX2-8	3	13	16	1132.573
#472	FOXE1	3	17	20	424.674
#473	MLXIPL	3	15	18	214.093
#474	IRF5	3	13	16	409.137
#475	SMAD6	3	11	14	2204.88
#476	YY1	3	15	18	828.672
#477	LEF1	3	20	23	644.924
#478	TCF21	3	14	17	636.269
#479	RORB	3	14	17	386.197
#480	ESRRG	3	19	22	476.626
#481	ALX3	3	12	15	579.008
#482	CREB5	3	18	21	926.316
#483	CREM	3	20	23	596.657
#484	ZNF165	3	13	16	486.744
#485	NPAS1	3	20	23	1200.218
#486	CREBBP	2	17	19	954.172
#487	POU3F1	2	17	19	465.158
#488	EGR4	2	16	18	147.498
#489	MSX2	2	21	23	198.045
#490	VTN	2	14	16	1270.108
#491	KDM5B	2	17	19	323.932
#492	PKNOX1	2	16	18	282.528
#493	POU1F1	2	18	20	456.811
#494	ZNF639	2	17	19	248.016
#495	RFXAP	2	17	19	290.575
#496	GATA4	2	18	20	824.933
#497	ZNF167	2	16	18	632.824
#498	SALL1	2	25	27	224.238
#499	IRF4	1	13	14	359.249
#500	ZNF154	1	14	15	127.323