Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	E2F4	348	2	350	1523.117
#2	HOXD9	316	1	317	757.746
#3	STRN3	314	5	319	4695.993
#4	TAF5	313	3	316	4218.087
#5	DDIT3	312	4	316	6415.943
#6	PAX6	311	6	317	3139.395
#7	NKX3-2	311	1	312	3405.969
#8	REXO4	307	1	308	263.49
#9	PRRX2	299	4	303	2816.243
#10	VAX2	297	4	301	4178.934
#11	PAX8	100	2	102	1950.808
#12	BACH2	46	6	52	712.848
#13	TAL1	44	7	51	1830.211
#14	LASS2	44	8	52	1041.14
#15	EDF1	42	5	47	1536.352
#16	ZEB2	42	8	50	820.717
#17	THRA	41	15	56	3412.662
#18	STAT2	41	14	55	3636.916
#19	EN2	41	3	44	1481.374
#20	FOXA1	40	11	51	1344.492
#21	ARNTL2	39	4	43	759.97
#22	ARID4A	39	12	51	3107.041
#23	ZNF434	38	7	45	758.804
#24	CREBL2	37	5	42	326.493
#25	SMAD4	36	12	48	1950.706
#26	HDAC2	36	6	42	1183.927
#27	AEBP1	36	13	49	1219.037
#28	ZNF232	36	10	46	1100.93
#29	KLF2	35	9	44	1143.523
#30	SLC2A4RG	35	9	44	559.28
#31	YBX1	35	3	38	311.254
#32	E2F1	35	12	47	1519.223
#33	HDAC1	34	7	41	636.462
#34	HOXC13	34	3	37	928.666
#35	TCEAL1	33	7	40	1023.353
#36	HLF	32	9	41	2330.49
#37	KDM5A	32	11	43	1468.887
#38	LASS6	32	9	41	1300.16
#39	NFAT5	32	11	43	1828.46
#40	NFIX	31	5	36	521.827
#41	HHEX	31	14	45	854.982
#42	MEIS2	31	11	42	1900.983
#43	NFE2L3	30	18	48	2996.517
#44	IRX5	30	12	42	938.019
#45	TP63	30	12	42	1523.045
#46	HOXD3	30	9	39	2218.54
#47	BCL11B	29	9	38	467.832
#48	NFKB1	28	12	40	853.357
#49	PRDM2	27	14	41	1054.099
#50	MAF	27	11	38	1018.08
#51	ZNF45	27	22	49	1912.768
#52	NOTCH1	27	18	45	2927.929
#53	HOXA7	27	16	43	920.198
#54	MAFB	27	13	40	1274.005
#55	HOXC10	26	10	36	1462.694
#56	RB1	26	6	32	1354.229
#57	TAF7	26	2	28	259.162
#58	IRF8	26	19	45	1529.582
#59	FOXJ3	25	16	41	742.992
#60	ENO1	25	10	35	814.859
#61	ESR1	25	20	45	1198.29
#62	CEBPD	24	18	42	560.915
#63	SPEN	24	12	36	1790.325
#64	BRD8	24	6	30	1446.492
#65	ZNF83	24	8	32	684.236
#66	ZNF193	24	22	46	683.403
#67	KLF11	24	15	39	1358.844
#68	HMGB1	24	6	30	463.707
#69	MSRB2	23	4	27	459.528
#70	CREBBP	23	5	28	275.335
#71	MEOX2	23	17	40	975.733
#72	HMGB2	23	10	33	1008.915
#73	SNAI2	23	10	33	1450.975
#74	CTCF	23	9	32	1060.837
#75	PROX1	23	22	45	2454.038
#76	ZBTB38	23	5	28	280.327
#77	PA2G4	22	10	32	1203.348
#78	TBX6	22	25	47	1174.93
#79	IRF1	22	21	43	704.652
#80	ZNF35	22	26	48	2050.942
#81	FOXF2	22	9	31	837.209
#82	TRIM28	22	5	27	1212.123
#83	SOX12	22	28	50	1145.263
#84	KLF5	22	23	45	1226.332
#85	ARNT	22	25	47	1224.606
#86	ZNF189	21	10	31	455.405
#87	ZNF444	21	18	39	2288.641
#88	SNAPC5	21	10	31	637.503
#89	PAX4	21	22	43	1496.748
#90	ZNF174	21	21	42	1256.759
#91	ATF1	21	11	32	463.959
#92	MEF2C	21	25	46	1476.546
#93	TFAP2C	21	7	28	1323.625
#94	MLL	21	22	43	949.892
#95	TCF20	21	12	33	990.218
#96	MNT	21	24	45	1379.98
#97	MEOX1	20	25	45	1197.389
#98	DMTF1	20	12	32	663.62
#99	GLI2	20	23	43	1285.821
#100	DRAP1	20	7	27	539.374
#101	HMG20A	20	6	26	1544.703
#102	ZNF187	20	22	42	1467.264
#103	IRF6	20	5	25	608.783
#104	BHLHE40	20	19	39	837.272
#105	KLF7	20	15	35	2038.631
#106	SMAD3	20	25	45	1354.732
#107	IRF9	20	9	29	714.393
#108	NFYB	20	22	42	656.305
#109	RARB	20	27	47	2660.893
#110	MEF2D	20	18	38	1854.42
#111	GATA3	20	12	32	491.888
#112	TWIST1	20	11	31	865.816
#113	RUNX3	20	24	44	914.805
#114	E4F1	19	24	43	1180.234
#115	TFAP2B	19	31	50	1910.479
#116	NR4A1	19	15	34	304.666
#117	BTG2	19	25	44	1493.096
#118	EGR1	19	7	26	582.411
#119	FOSB	19	14	33	489.953
#120	ZKSCAN1	19	9	28	249.387
#121	TFAP2A	19	10	29	639.48
#122	FOXC1	19	24	43	1272.696
#123	RBCK1	19	10	29	471.652
#124	TFEC	19	21	40	498
#125	POU4F1	19	25	44	1086.545
#126	NFYC	19	21	40	584.843
#127	NKX3-1	18	26	44	1402.095
#128	RUNX2	18	19	37	1490.306
#129	KDM5B	18	6	24	309.795
#130	GLI3	18	21	39	939.465
#131	TBP	18	9	27	620.584
#132	BTAF1	18	9	27	1253.281
#133	HES1	18	6	24	229.011
#134	CNBP	18	4	22	400.843
#135	SOX17	18	26	44	1409.992
#136	LMO4	18	22	40	778.471
#137	ZNF263	18	16	34	940.585
#138	CSRNP2	18	20	38	1500.818
#139	TAF4	17	4	21	100.311
#140	HNRNPAB	17	8	25	433.66
#141	GAS7	17	19	36	682.04
#142	FOXN3	17	22	39	1282.548
#143	SALL2	17	17	34	1168.806
#144	BACH1	17	15	32	784.998
#145	TRIM29	17	31	48	2727.847
#146	ASCL1	17	19	36	896.988
#147	SALL1	17	19	36	1116.819
#148	NR2C1	17	13	30	486.001
#149	GATAD1	17	13	30	517.238
#150	ZFP36L1	17	13	30	395.411
#151	FOS	17	20	37	508.568
#152	DLX4	17	26	43	1014.327
#153	ECSIT	17	29	46	1547.821
#154	RERE	17	23	40	979.069
#155	POU2F2	16	7	23	719.565
#156	RFXANK	16	30	46	964.844
#157	TFAM	16	27	43	865.837
#158	KLF3	16	28	44	1059.547
#159	SMAD2	16	15	31	643.509
#160	SNAPC2	16	26	42	1557.243
#161	ZNF197	16	19	35	1067.642
#162	TGIF2	16	22	38	649.701
#163	ZNF268	16	28	44	1667.846
#164	RXRA	16	21	37	1109.484
#165	ZBTB17	16	20	36	1731.874
#166	TEAD3	16	18	34	794.425
#167	YEATS4	16	24	40	1167.598
#168	GRHL2	16	11	27	678.129
#169	ATF3	16	11	27	1020.949
#170	ZNF165	16	28	44	1500.901
#171	CLOCK	16	7	23	263.96
#172	ZNF236	16	21	37	1104.388
#173	EGR3	16	11	27	606.797
#174	ZNF281	16	13	29	516.034
#175	ZKSCAN3	16	10	26	931.233
#176	ZNF217	16	10	26	461.363
#177	ZNF207	16	7	23	408.167
#178	SOX18	15	24	39	1020.089
#179	FOXO3	15	5	20	198.124
#180	PPARA	15	15	30	922.288
#181	MSL3	15	23	38	1194.771
#182	SP3	15	6	21	218.136
#183	ZNF202	15	20	35	783.537
#184	SCAND1	15	14	29	751.806
#185	AFF1	15	25	40	1033.15
#186	MTA1	15	28	43	1204.253
#187	LEF1	15	16	31	654.503
#188	SIX6	15	21	36	385.697
#189	ETS2	15	22	37	693.836
#190	PITX1	15	24	39	916.432
#191	GCFC1	15	8	23	952.461
#192	NFE2L1	15	14	29	365.5
#193	NPAS2	15	27	42	1313.877
#194	TAF6	15	13	28	737.15
#195	PITX2	15	20	35	1406.654
#196	FOXO1	15	20	35	1141.053
#197	ATF2	15	27	42	1016.103
#198	MEIS1	14	26	40	938.349
#199	LZTR1	14	14	28	590.74
#200	ETV5	14	24	38	604.272
#201	TARDBP	14	10	24	306.61
#202	ZGPAT	14	19	33	428.619
#203	ZHX2	14	16	30	477.145
#204	PLSCR1	14	10	24	320.764
#205	TAF1B	14	22	36	756.345
#206	CITED2	14	31	45	772.21
#207	HSF2	14	19	33	585.779
#208	ZIC1	14	21	35	790.834
#209	ZNF140	14	26	40	1046.797
#210	ELF2	14	22	36	720.369
#211	SPDEF	14	25	39	571.77
#212	SREBF1	14	14	28	568.782
#213	E2F8	14	22	36	558.402
#214	ETV1	14	27	41	1359.275
#215	HMG20B	14	14	28	942.286
#216	MITF	14	26	40	1091.377
#217	NR1H2	14	25	39	384.222
#218	SOX11	14	22	36	511.931
#219	CNOT8	14	21	35	649.281
#220	STAT1	14	25	39	806.839
#221	FBXW7	14	25	39	743.696
#222	MAFF	14	12	26	909.422
#223	ERF	14	30	44	1465.556
#224	TBX3	14	15	29	1298.986
#225	EN1	14	23	37	2517.496
#226	ERG	14	28	42	1737.371
#227	NR5A2	14	8	22	722.651
#228	MGA	14	19	33	366.136
#229	VDR	13	37	50	1023.004
#230	HOXA6	13	26	39	903.675
#231	REL	13	24	37	4006.467
#232	PEG3	13	29	42	1062.121
#233	YY1	13	28	41	899.629
#234	MBD1	13	15	28	422.057
#235	E2F3	13	32	45	1282.811
#236	RNF4	13	6	19	704.637
#237	ESRRG	13	23	36	608.112
#238	SOLH	13	18	31	832.113
#239	TAF10	13	11	24	1098.208
#240	ADNP2	13	17	30	1035.218
#241	NFATC3	13	26	39	743.345
#242	ZNF238	13	20	33	927.687
#243	FLI1	13	23	36	634.85
#244	ALS2CR8	13	22	35	1123.267
#245	HAND1	13	9	22	339.564
#246	ETV7	13	27	40	1279.514
#247	POU3F1	13	9	22	439.923
#248	CIR1	13	29	42	1506.473
#249	TCF7L2	13	31	44	902.627
#250	MEIS3P1	13	13	26	1336.4
#251	AHR	13	11	24	594.448
#252	PTTG1	13	18	31	1081.232
#253	CBFB	12	26	38	1129.784
#254	CREB1	12	25	37	618.982
#255	PKNOX1	12	23	35	1065.343
#256	ZNF131	12	24	36	1525.627
#257	SOX9	12	25	37	753.297
#258	HEY2	12	28	40	900.528
#259	CSDA	12	24	36	816.578
#260	NCOR1	12	6	18	113.169
#261	TULP4	12	6	18	183.408
#262	CITED1	12	22	34	1519.266
#263	RFX3	12	27	39	1018.443
#264	MYCL1	12	23	35	2330.006
#265	CUX2	12	18	30	656.822
#266	HOXA5	12	20	32	501.147
#267	SCML2	12	14	26	674.58
#268	SUPT6H	12	29	41	620.071
#269	MZF1	12	23	35	1041.753
#270	NR2F1	12	23	35	635.843
#271	MSC	11	22	33	698.808
#272	ELF4	11	29	40	916.225
#273	MYCN	11	23	34	1046.629
#274	CBFA2T2	11	30	41	570.255
#275	NR0B1	11	22	33	1257.174
#276	TEAD4	11	31	42	768.589
#277	MLX	11	25	36	909.113
#278	RUNX1T1	11	23	34	424.588
#279	SP140	11	25	36	690.963
#280	MSX1	11	25	36	1143.38
#281	PFDN1	11	15	26	543.888
#282	KLF6	11	29	40	657.959
#283	ZNF91	11	15	26	312.216
#284	GTF2H4	11	28	39	682.451
#285	TBX10	11	20	31	631.203
#286	BHLHE41	11	28	39	1055.524
#287	ZNF75D	11	28	39	885.506
#288	SLC26A3	11	20	31	820.772
#289	ZFPM2	11	24	35	353.463
#290	IRF2	11	17	28	549.958
#291	RELB	11	13	24	1085.615
#292	MYNN	11	18	29	925.682
#293	AR	11	28	39	296.978
#294	BLZF1	11	22	33	765.217
#295	PBX1	11	30	41	529.277
#296	ZNF148	11	6	17	249.36
#297	STAT5B	11	27	38	608.868
#298	IKZF4	10	20	30	741.23
#299	NR4A3	10	33	43	1227.02
#300	TFCP2	10	30	40	471.777
#301	ZNF277	10	24	34	453.595
#302	MLLT10	10	22	32	741.753
#303	ZNF85	10	25	35	739.297
#304	CEBPA	10	31	41	611.478
#305	VAV1	10	20	30	365.377
#306	NFKB2	10	28	38	1597.197
#307	ZNF175	10	21	31	1047.824
#308	HOXB6	10	24	34	1001.703
#309	TCF3	10	24	34	687.126
#310	HOXA9	10	18	28	268.437
#311	ETV6	10	28	38	764.947
#312	SPI1	10	26	36	1077.383
#313	NFYA	10	31	41	477.407
#314	GTF2IRD1	10	32	42	666.765
#315	E2F5	10	24	34	874.812
#316	ZKSCAN4	10	8	18	548.731
#317	GTF2I	10	29	39	615.291
#318	NFATC4	10	16	26	4419.606
#319	SPIB	9	26	35	838.398
#320	STAT6	9	18	27	2430.216
#321	SOX2	9	13	22	778.212
#322	ZNF134	9	10	19	960.574
#323	SOX4	9	30	39	613.681
#324	ELK1	9	22	31	516.763
#325	HMBOX1	9	26	35	485.231
#326	BCL3	9	5	14	376.87
#327	SMAD1	9	29	38	1208.173
#328	NEUROD2	9	29	38	891.438
#329	ZSCAN18	9	26	35	616.525
#330	GATA2	9	28	37	542.941
#331	CREM	9	32	41	1617.274
#332	POU4F2	9	22	31	352.17
#333	TEAD1	9	28	37	1019.129
#334	IRF7	9	19	28	919.647
#335	ARNT2	9	26	35	730.694
#336	JUN	9	26	35	1069.334
#337	HOXD4	9	27	36	1102.544
#338	GATA6	9	32	41	654.161
#339	HMGA1	9	33	42	768.513
#340	CUX1	9	25	34	3244.733
#341	FOXK2	9	14	23	803.086
#342	MMP14	9	21	30	2205.638
#343	HMGA2	9	28	37	1356.374
#344	NR1H3	9	25	34	831.828
#345	ATF5	9	30	39	1431.624
#346	EHF	9	26	35	589.091
#347	NFIC	9	29	38	973.37
#348	HOXB7	9	25	34	329.647
#349	ZNF3	9	12	21	393.517
#350	NOLC1	9	29	38	683.164
#351	ZNF287	9	20	29	606.067
#352	TFDP1	9	25	34	629.37
#353	PBX2	8	23	31	1040.502
#354	ZFHX3	8	28	36	790.769
#355	PHTF1	8	25	33	338.731
#356	MECOM	8	31	39	1124.48
#357	ELF3	8	16	24	450.608
#358	SIM2	8	24	32	472.156
#359	ZSCAN16	8	25	33	678.282
#360	SOX10	8	11	19	797.791
#361	TFEB	8	24	32	1191.355
#362	ZBTB25	8	26	34	617.5
#363	PGR	8	15	23	743.508
#364	TFCP2L1	8	10	18	502.494
#365	TFE3	8	27	35	383.855
#366	ZSCAN5A	8	25	33	529.173
#367	MNX1	8	28	36	435.517
#368	BCL6	8	12	20	528.688
#369	SMAD5	8	30	38	868.986
#370	FOXD1	8	15	23	764.764
#371	NR2F6	8	28	36	504.169
#372	TCF7	8	28	36	909.895
#373	FOXN2	8	24	32	622.447
#374	NFIB	8	23	31	513.221
#375	AATF	8	20	28	302.445
#376	FOXM1	8	21	29	478.777
#377	C2orf3	8	10	18	572.547
#378	CDKN2A	8	27	35	1461.295
#379	CREB5	8	11	19	426.617
#380	RFX5	8	32	40	774.499
#381	SUPT4H1	8	30	38	807.652
#382	SIX1	8	23	31	428.307
#383	ZNF323	8	28	36	551.522
#384	TSC22D4	7	10	17	474.669
#385	DLX2	7	7	14	289.237
#386	ZEB1	7	29	36	669.464
#387	CCRN4L	7	28	35	1154.943
#388	ZHX3	7	31	38	1082.12
#389	SP1	7	18	25	939.458
#390	PLAGL2	7	34	41	1122.529
#391	USF2	7	31	38	720.931
#392	ATF6	7	8	15	723.624
#393	PCGF2	7	31	38	410.828
#394	TCF4	7	30	37	796.628
#395	CBFA2T3	7	25	32	406.488
#396	JUND	7	11	18	2739.662
#397	ZNF219	7	13	20	792.222
#398	RORA	7	34	41	1329.981
#399	IRF4	7	19	26	175.672
#400	ZKSCAN5	7	26	33	889.434
#401	SRF	7	28	35	572.895
#402	TCFL5	7	28	35	433.358
#403	ZNF135	7	10	17	415.194
#404	PLAG1	7	24	31	530.344
#405	WNT5A	7	34	41	838.734
#406	STAT5A	7	30	37	930.098
#407	ZNF500	7	26	33	407.185
#408	ZNF117	7	31	38	931.858
#409	MSX2	6	26	32	222.691
#410	ZFHX4	6	23	29	655.941
#411	TBX1	6	17	23	642.992
#412	NR3C1	6	22	28	474.422
#413	SATB2	6	21	27	475.307
#414	ESRRA	6	33	39	3800.429
#415	EGR2	6	26	32	312.182
#416	LHX3	6	22	28	373.877
#417	HOXB2	6	33	39	550.711
#418	KLF12	6	34	40	1456.606
#419	LHX6	6	35	41	1299.308
#420	TP53	6	28	34	830.15
#421	ZNF274	6	25	31	760.904
#422	STAT3	6	33	39	1697.186
#423	TBX2	6	21	27	331.248
#424	SCML1	6	27	33	679
#425	SREBF2	6	28	34	463.592
#426	RUNX1	6	27	33	469.607
#427	KLF4	6	14	20	256.022
#428	SMAD6	6	15	21	327.705
#429	ESR2	6	22	28	478.81
#430	HOXB5	6	27	33	451.704
#431	NFX1	6	29	35	712.001
#432	PPARD	6	26	32	1184.532
#433	ZSCAN12	6	21	27	571.341
#434	PURA	5	29	34	333.185
#435	ZBTB48	5	16	21	514.658
#436	TFDP2	5	24	29	794.5
#437	SCMH1	5	25	30	364.557
#438	TADA2A	5	24	29	331.295
#439	RCAN1	5	27	32	501.185
#440	TAF5L	5	32	37	750.606
#441	NFATC1	5	25	30	1408.597
#442	ZXDC	5	26	31	685.322
#443	ATF6B	5	26	31	1032.854
#444	ZNF33B	5	29	34	871.997
#445	ZNF167	5	23	28	871.383
#446	HOXC8	5	14	19	349.459
#447	ELF5	5	37	42	2169.672
#448	ZNF81	5	13	18	207.627
#449	HOPX	5	31	36	422.588
#450	IRF5	5	32	37	1447.61
#451	ELF1	5	35	40	579.783
#452	NR4A2	5	24	29	135.266
#453	LZTS1	5	13	18	400.341
#454	HR	5	13	18	244.891
#455	RELA	5	31	36	426.744
#456	MYC	5	26	31	306.715
#457	E2F6	5	30	35	466.276
#458	SATB1	5	34	39	507.742
#459	WT1	5	20	25	323.766
#460	PBX3	5	11	16	164.63
#461	NPAT	5	18	23	486.156
#462	FUBP1	4	24	28	314.313
#463	ZNF93	4	31	35	215.143
#464	IKZF1	4	23	27	372.869
#465	MTF1	4	29	33	489.631
#466	UBN1	4	22	26	342.322
#467	MAFG	4	31	35	491.77
#468	EPAS1	4	21	25	243.469
#469	PKNOX2	4	25	29	632.261
#470	HSF1	4	28	32	396.488
#471	AHCTF1	4	29	33	488.741
#472	MAX	4	28	32	215.841
#473	IRX4	4	21	25	238.407
#474	TADA3	4	30	34	240.054
#475	KLF9	4	31	35	350.159
#476	SOX13	4	34	38	712.637
#477	POU2F1	4	32	36	601.653
#478	HOXD1	4	32	36	713.823
#479	NR3C2	4	28	32	556.619
#480	NR2F2	3	31	34	450.623
#481	RARA	3	30	33	191.327
#482	GATAD2A	3	32	35	445.897
#483	DBP	3	30	33	279.459
#484	SIX2	3	32	35	300.636
#485	FOSL2	3	39	42	290.591
#486	MEF2A	3	25	28	227.702
#487	TSC22D3	3	21	24	495.126
#488	CREB3L1	3	11	14	633.576
#489	ZNF24	3	11	14	167.441
#490	HOXA10	3	19	22	80.429
#491	CTBP1	3	33	36	434.135
#492	HOXC11	2	32	34	258.773
#493	ZFP36L2	2	31	33	371.911
#494	NR2E3	2	26	28	274.54
#495	NR1D2	2	24	26	69.368
#496	CREBZF	2	34	36	154.471
#497	CREB3	2	28	30	761.119
#498	TBX21	2	26	28	230.28
#499	GTF2H3	2	30	32	126.244
#500	FOXI1	1	26	27	214.531