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Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	NKX6-2	477	0	477	0
#2	ZNF215	449	2	451	2400.097
#3	POU5F1	441	1	442	5464.185
#4	NEUROG1	54	6	60	812.302
#5	GATAD2B	47	6	53	1913.13
#6	PHF1	41	2	43	387.291
#7	ZNF90	40	7	47	349.095
#8	UBN1	39	5	44	385.64
#9	BLZF1	36	9	45	380.508
#10	SP140	35	8	43	231.427
#11	SCAND3	35	4	39	920.747
#12	HDAC1	33	5	38	89.506
#13	ZHX2	32	10	42	445.129
#14	ZNF133	32	16	48	2639.129
#15	ARNT	31	9	40	1763.869
#16	HOXD13	31	11	42	424.211
#17	PGBD1	30	16	46	1551.711
#18	ELK3	29	19	48	3366.502
#19	MLL	29	11	40	790.388
#20	STAT4	28	12	40	799.794
#21	FOXA2	28	9	37	816.92
#22	ADNP2	28	4	32	778.278
#23	ISL1	28	8	36	162.134
#24	UBP1	28	9	37	814.645
#25	TARDBP	27	10	37	722.805
#26	E2F4	27	14	41	1025.017
#27	ZNF323	27	11	38	353.562
#28	C11orf9	27	6	33	402.369
#29	ESR2	27	7	34	323.168
#30	TCF25	26	16	42	967.835
#31	E2F1	26	8	34	184.737
#32	TAF13	26	15	41	2719.08
#33	MTF1	26	10	36	1043.12
#34	ATOH1	26	16	42	1664.683
#35	DRAP1	26	10	36	864.067
#36	DMRT1	26	20	46	2151.065
#37	DLX4	26	14	40	1131.158
#38	ZBTB25	25	8	33	491.889
#39	MTA3	25	7	32	251.901
#40	TFCP2	25	17	42	920.543
#41	FOXF1	25	20	45	2019.314
#42	PPARA	25	13	38	698.931
#43	HOXB2	25	13	38	606.661
#44	DLX2	25	5	30	55.059
#45	STRN3	25	13	38	779.906
#46	HES5	24	12	36	934.09
#47	ZNF33B	24	13	37	1260.439
#48	ZNF500	24	14	38	1355.055
#49	NFKB2	24	12	36	364.319
#50	AHCTF1	24	11	35	430.982
#51	MSX1	24	20	44	1266.065
#52	SIM2	24	16	40	712.816
#53	SATB2	24	8	32	1201.715
#54	NFE2L1	24	15	39	1001.638
#55	HOXB3	23	4	27	462.374
#56	HIC1	23	19	42	1270.725
#57	GATA3	23	22	45	1405.855
#58	WNT5A	23	13	36	775.391
#59	NFYA	23	21	44	1754.702
#60	HOXA1	23	12	35	665.498
#61	TCF15	23	15	38	1492.196
#62	BARHL1	23	14	37	648.32
#63	SIX1	22	17	39	1431.703
#64	ZIM2	22	20	42	2088.931
#65	NKX6-1	22	13	35	642.669
#66	HMGB1	22	17	39	1130.617
#67	FOXP4	22	12	34	929.742
#68	IRX1	22	9	31	1134.89
#69	ELF3	22	18	40	1416.45
#70	HES1	22	17	39	1529.555
#71	TAF10	22	20	42	1132.137
#72	ALX4	22	16	38	1584.641
#73	TAF12	22	9	31	866.757
#74	PAX7	22	11	33	342.27
#75	MAFG	22	8	30	689.322
#76	NR3C2	21	18	39	1732.315
#77	PCGF2	21	19	40	1219.331
#78	RFXANK	21	11	32	503.263
#79	SHOX	21	16	37	1342.454
#80	SOLH	21	14	35	632.317
#81	HES6	21	23	44	1784.943
#82	ZNF85	21	18	39	1497.239
#83	RCOR2	21	9	30	927.437
#84	MESP1	21	15	36	799.246
#85	ZNF197	21	13	34	829.54
#86	JUND	21	5	26	430.372
#87	TGIF2	21	10	31	484.29
#88	TEAD3	21	18	39	973.73
#89	FOXA3	21	17	38	2020.525
#90	NFX1	20	6	26	48.691
#91	FOXC1	20	15	35	1362.729
#92	NFATC1	20	18	38	1678.684
#93	HIF1A	20	13	33	707.343
#94	NR2F1	20	14	34	519.223
#95	RFXAP	20	8	28	795.776
#96	RUNX2	20	11	31	661.235
#97	SCAND2	20	12	32	465.517
#98	NR3C1	20	21	41	1459.567
#99	HOXC12	20	12	32	997.977
#100	FUBP1	20	10	30	627.415
#101	RORC	20	20	40	1461.337
#102	C5orf41	20	8	28	925.497
#103	FOXL1	20	17	37	938.306
#104	RERE	20	20	40	1373.916
#105	ZNF80	20	21	41	1903.614
#106	MYC	20	14	34	983.546
#107	SIM1	20	7	27	327.096
#108	IRF4	19	17	36	1750.441
#109	SCML2	19	16	35	966.698
#110	OTX1	19	2	21	8.59
#111	CBFA2T2	19	13	32	920.211
#112	CCRN4L	19	20	39	1651.169
#113	ZFP37	19	16	35	1083.624
#114	NCOR1	19	12	31	460.522
#115	TAF7	19	15	34	1230.354
#116	ZIC3	19	18	37	1146.841
#117	TFAP2A	19	10	29	601.898
#118	NR1H2	19	9	28	596.91
#119	SIX5	19	6	25	753.879
#120	BUD31	19	16	35	1263.666
#121	HLF	19	10	29	862.01
#122	LASS6	19	18	37	7037.179
#123	EBF1	19	10	29	571.682
#124	MSRB2	18	18	36	993.726
#125	EVX1	18	14	32	1260.364
#126	ENO1	18	18	36	1815.103
#127	ZNF187	18	17	35	1222.938
#128	FOXP1	18	20	38	1219.04
#129	SP3	18	15	33	996.818
#130	ZXDA	18	21	39	1601.653
#131	NFYC	18	18	36	1206.099
#132	EN1	18	14	32	573.65
#133	ZNF394	18	16	34	1080.852
#134	SMAD1	18	26	44	2185.963
#135	BATF3	18	18	36	1324.72
#136	PITX2	18	17	35	1054.785
#137	NANOGP1	18	13	31	837.439
#138	JDP2	18	11	29	666.098
#139	PA2G4	18	33	51	3270.308
#140	ARX	18	11	29	1068.555
#141	HOXC13	18	15	33	495.875
#142	GAS7	18	13	31	920.34
#143	SOX9	18	13	31	1041.316
#144	FOXQ1	18	7	25	339.681
#145	ZNF33A	18	5	23	422.758
#146	GRHL2	17	17	34	1011.676
#147	SCRT1	17	9	26	760.844
#148	RFX5	17	21	38	1412.898
#149	RXRA	17	21	38	1439.793
#150	ERF	17	14	31	1453.549
#151	CNOT7	17	11	28	959.788
#152	STAT3	17	17	34	819.249
#153	CTNNB1	17	8	25	885.788
#154	PURA	17	19	36	1297.895
#155	POU5F2	17	14	31	570.313
#156	LHX4	17	12	29	420.21
#157	LHX1	17	20	37	1532.224
#158	HOXB5	17	11	28	584.594
#159	BHLHE40	17	19	36	1606.511
#160	CREBBP	17	16	33	837.85
#161	GTF2I	17	15	32	574.011
#162	SOX11	17	17	34	1494.203
#163	FOXK2	17	6	23	527.055
#164	T	17	18	35	1057.472
#165	MAX	17	15	32	637.035
#166	RARG	17	12	29	365.788
#167	SMAD6	17	15	32	1268.584
#168	LMX1B	17	24	41	1487.675
#169	SOX17	17	18	35	1584.371
#170	HOXD9	17	17	34	1050.368
#171	TCF19	17	13	30	699.25
#172	SIX2	16	5	21	630.769
#173	JUN	16	22	38	1366.855
#174	RFX3	16	19	35	1279.923
#175	ZNF69	16	19	35	885.693
#176	CREM	16	21	37	1437.522
#177	CUX2	16	20	36	1385.043
#178	ONECUT1	16	22	38	907.566
#179	FOXJ1	16	16	32	808.502
#180	PFDN1	16	12	28	766.628
#181	PPARD	16	13	29	1317.291
#182	NFYB	16	20	36	1473.782
#183	SMAD2	16	8	24	467.163
#184	ZNF189	16	22	38	1313.124
#185	ZNF148	16	6	22	1481.196
#186	MAFA	16	17	33	1735.091
#187	CEBPA	16	7	23	78.882
#188	RBPJ	16	16	32	985.766
#189	SRY	16	24	40	1274.812
#190	HOXA9	16	20	36	655.043
#191	ZNF3	16	15	31	1287.371
#192	MYOG	16	16	32	1623.243
#193	KDM5B	16	18	34	943.153
#194	ZNF24	16	13	29	674.498
#195	HSF5	16	12	28	2394.101
#196	TULP4	15	29	44	1847.34
#197	TCF7	15	10	25	507.233
#198	FOSB	15	15	30	1224.583
#199	ZNF75D	15	8	23	486.019
#200	TBX3	15	19	34	907.626
#201	PKNOX2	15	18	33	1171.229
#202	PRRX1	15	14	29	488.074
#203	PLAG1	15	19	34	1552.183
#204	TCFL5	15	9	24	820.969
#205	GTF2H3	15	6	21	31.262
#206	HOXA2	15	17	32	727.384
#207	IRX6	15	18	33	957.944
#208	TBX15	15	12	27	663.841
#209	EGR3	15	19	34	881.467
#210	PKNOX1	15	18	33	907.991
#211	FOXN2	15	17	32	901.048
#212	TBX22	15	23	38	1092.501
#213	HOXB13	15	11	26	659.399
#214	IRX3	15	12	27	517.879
#215	POU1F1	15	15	30	979.046
#216	STAT2	15	20	35	1167.44
#217	HMGA1	15	20	35	1300.304
#218	SOX8	15	17	32	1148.84
#219	RORB	14	20	34	978.887
#220	NR1I2	14	11	25	738.317
#221	RNF4	14	19	33	837.196
#222	CREB1	14	16	30	650.551
#223	AFF4	14	20	34	1495.454
#224	TAL1	14	16	30	747.306
#225	RELA	14	18	32	866.289
#226	HOXB9	14	12	26	755.403
#227	PURB	14	15	29	1030.06
#228	PAX3	14	15	29	921.125
#229	IRF7	14	17	31	597.789
#230	FOXB1	14	16	30	777.639
#231	HNF4G	14	24	38	1557.209
#232	IKZF3	14	19	33	930.325
#233	CREB3L3	14	19	33	1079.748
#234	NR1D2	14	23	37	1001.452
#235	ATF1	14	16	30	955.906
#236	ZNF628	14	25	39	1395.405
#237	FOXA1	14	5	19	62.951
#238	ETV5	14	21	35	792.952
#239	ATF3	14	13	27	414.434
#240	HMGA2	14	22	36	1128.786
#241	STAT5A	14	23	37	1168.219
#242	CSRNP2	14	17	31	1240.29
#243	TRIM25	14	17	31	641.594
#244	ELF5	13	21	34	812.31
#245	TP53	13	20	33	989.331
#246	CEBPB	13	16	29	606.264
#247	TLX2	13	17	30	937.837
#248	MSX2	13	18	31	1127.584
#249	NFIB	13	18	31	686.393
#250	NR2F6	13	16	29	818.742
#251	TBP	13	21	34	1197.842
#252	SMAD9	13	21	34	920.374
#253	POU3F1	13	8	21	300.572
#254	NR4A1	13	13	26	706.744
#255	ZIC1	13	19	32	827.26
#256	SOX2	13	22	35	1226.518
#257	EHF	13	19	32	636.876
#258	ZSCAN29	13	16	29	949.475
#259	SIX3	13	16	29	698.895
#260	TP63	13	15	28	585.828
#261	DLX3	13	15	28	681.993
#262	SMAD4	13	15	28	895.878
#263	FBXW7	13	17	30	694.476
#264	XBP1	13	12	25	621.892
#265	ADNP	13	16	29	1333.634
#266	PPBPL2	13	13	26	408.583
#267	FOXC2	13	26	39	1464.386
#268	ECSIT	13	13	26	488.732
#269	L3MBTL4	13	20	33	849.967
#270	ESX1	13	19	32	729.483
#271	CBL	13	14	27	772.9
#272	FOSL1	13	16	29	849.152
#273	CSDA	13	13	26	296.552
#274	FOXP3	13	15	28	798.447
#275	TFAP2B	13	13	26	939.331
#276	PLAGL2	13	16	29	961.73
#277	TWIST2	13	12	25	480.339
#278	TRIM28	13	13	26	406.256
#279	ZSCAN18	12	14	26	716.298
#280	RHOXF1	12	22	34	902.731
#281	ZNF135	12	18	30	1059.603
#282	MECOM	12	28	40	1110.852
#283	KLF15	12	16	28	802.701
#284	SP4	12	12	24	540.095
#285	GCFC1	12	20	32	713.509
#286	HOPX	12	15	27	1175.681
#287	HOXC9	12	21	33	1074.839
#288	FOXD4	12	20	32	965.328
#289	MYCN	12	17	29	778.261
#290	TBX2	12	21	33	1767.28
#291	HNRNPK	12	19	31	853.565
#292	ZC3H8	12	18	30	767.882
#293	ZFP36L1	12	20	32	1062.166
#294	HSF4	12	9	21	267.605
#295	HAND1	12	19	31	725.062
#296	NME2	12	18	30	570.152
#297	ZNF134	12	25	37	1090.58
#298	SNAI2	12	16	28	663.626
#299	KCNH8	12	22	34	1272.64
#300	ZNF496	12	17	29	844.503
#301	MTA1	12	21	33	1242.052
#302	HOXD11	12	24	36	1083.531
#303	ETV3	12	22	34	717.955
#304	UHRF1	12	7	19	236.809
#305	ATF6	12	17	29	563.138
#306	AR	12	13	25	876.444
#307	AATF	12	13	25	910.933
#308	RBPJL	12	22	34	1323.551
#309	MXD1	12	18	30	980.019
#310	TFDP2	12	20	32	1078.073
#311	TRIM22	12	14	26	479.581
#312	LASS2	12	15	27	761.053
#313	NFKB1	12	22	34	1320.004
#314	SCAND1	11	26	37	922.059
#315	HINFP	11	20	31	1047.674
#316	GSC	11	24	35	1339.841
#317	KLF4	11	16	27	481.364
#318	GLIS3	11	18	29	989.388
#319	ASCL2	11	22	33	1171.646
#320	MYNN	11	13	24	308.176
#321	ARNT2	11	20	31	1677.489
#322	ZNF643	11	18	29	777.437
#323	ZNF70	11	20	31	961.005
#324	GATAD2A	11	19	30	685.553
#325	RUNX1T1	11	14	25	694.495
#326	NFE2L3	11	19	30	794.073
#327	TCF4	11	7	18	280.363
#328	SUPT4H1	11	18	29	527.336
#329	ETS1	11	22	33	800.906
#330	ZXDC	11	16	27	658.608
#331	ZNF92	11	15	26	591.22
#332	ZBTB17	11	23	34	1193.376
#333	SP1	11	20	31	1033.906
#334	SOX5	11	16	27	784.146
#335	YEATS4	11	19	30	446.111
#336	POU3F3	11	9	20	96.646
#337	ZSCAN12	11	21	32	1021.289
#338	NFXL1	11	21	32	996.61
#339	TSC22D3	11	24	35	1096.778
#340	HESX1	11	11	22	324.436
#341	ESRRA	11	22	33	908.946
#342	SPIB	11	19	30	665.106
#343	ELK4	11	17	28	629.924
#344	TPRX1	11	26	37	1350.976
#345	TRPS1	11	21	32	887.016
#346	RXRB	11	15	26	524.958
#347	ZNF117	11	28	39	1356.767
#348	ZKSCAN5	11	24	35	1510.19
#349	TFAM	11	13	24	505.404
#350	SMAD3	11	19	30	653.088
#351	ZKSCAN4	11	21	32	1534.504
#352	NR2C2	11	21	32	652.537
#353	ZSCAN22	11	16	27	1006.881
#354	ZNF397	11	23	34	741.385
#355	KLF9	11	24	35	1211.211
#356	NR1D1	11	20	31	947.082
#357	LEF1	11	27	38	1064.268
#358	AEBP1	11	17	28	852.119
#359	HCFC1	11	24	35	1037.698
#360	RORA	11	23	34	861.096
#361	NFIX	11	17	28	645.034
#362	ZNF236	11	29	40	2041.436
#363	SNAPC4	10	20	30	581.199
#364	ARNTL2	10	17	27	598.207
#365	ZRANB2	10	19	29	1048.282
#366	HEYL	10	19	29	811.924
#367	HOXD12	10	18	28	891.976
#368	CUX1	10	20	30	694.997
#369	HOXC4	10	16	26	585.579
#370	HOXA3	10	24	34	1017.267
#371	PPARG	10	18	28	1014.686
#372	FOXN3	10	23	33	727.282
#373	TFEC	10	14	24	619.331
#374	E2F2	10	23	33	1046.734
#375	ZNF18	10	21	31	593.74
#376	NFE2L2	10	31	41	1218.39
#377	CNBP	10	21	31	1258.807
#378	MAFF	10	16	26	853.496
#379	RAX2	10	23	33	1232.904
#380	ARID4A	10	26	36	1368.31
#381	ZNF71	10	22	32	592.601
#382	MLLT10	10	21	31	1171.064
#383	TRERF1	10	14	24	466.978
#384	IRX5	10	20	30	564.532
#385	SCRT2	10	15	25	719.792
#386	KLF6	10	20	30	668.576
#387	ZNF238	10	26	36	990.065
#388	GABPB1	10	14	24	426.953
#389	TCF3	10	21	31	632.101
#390	NFIA	10	20	30	723.061
#391	ATF2	10	14	24	764.871
#392	ZNF263	10	15	25	493.497
#393	NFATC2	10	19	29	686.859
#394	CLOCK	10	27	37	1113.704
#395	ESR1	10	21	31	795.928
#396	ZIC2	10	7	17	466.236
#397	IRF9	9	18	27	744.291
#398	NPAT	9	20	29	878.083
#399	ZNF438	9	23	32	911.129
#400	ZKSCAN1	9	20	29	537.556
#401	MEOX1	9	25	34	615.313
#402	HEY1	9	23	32	998.707
#403	MNX1	9	19	28	707.921
#404	LHX9	9	20	29	1263.238
#405	PHOX2B	9	14	23	400.75
#406	FOXE1	9	23	32	1252.18
#407	ZNF93	9	22	31	595.566
#408	HOXD3	9	17	26	570.915
#409	CITED2	9	17	26	704.506
#410	CNOT8	9	21	30	1413.033
#411	MEF2A	9	21	30	1013.11
#412	SPEN	9	26	35	790.376
#413	PITX1	9	20	29	999.771
#414	HIRA	9	23	32	718.107
#415	KLF1	9	25	34	1101.904
#416	WT1	9	27	36	982.899
#417	MEF2D	9	19	28	450.347
#418	ESRRB	9	27	36	1215.47
#419	ATF4	9	18	27	705.046
#420	CTCF	9	20	29	686.011
#421	FOXJ3	9	22	31	951.095
#422	TSC22D2	9	19	28	658.544
#423	MAF	9	31	40	1024.31
#424	SMAD5	9	23	32	569.425
#425	RCOR1	9	18	27	461.363
#426	TSHZ2	9	20	29	764.472
#427	RHOXF2	8	12	20	374.928
#428	RARA	8	23	31	831.462
#429	SLC26A3	8	19	27	542.716
#430	CTBP1	8	19	27	1184.64
#431	SPDEF	8	25	33	768.515
#432	ZNF192	8	22	30	602.028
#433	TAF1B	8	21	29	1121.37
#434	IKZF4	8	19	27	678.374
#435	NOLC1	8	18	26	561.504
#436	SRF	8	23	31	758.852
#437	CIR1	8	22	30	749.307
#438	FOXO4	8	21	29	607.405
#439	TRIM29	8	28	36	920.23
#440	RB1	8	10	18	367.068
#441	MBD1	7	25	32	699.581
#442	CDKN2A	7	14	21	261.87
#443	DLX6	7	21	28	500.523
#444	MLXIPL	7	26	33	843.043
#445	PBX3	7	21	28	650.479
#446	DMTF1	7	20	27	518.917
#447	ZSCAN10	7	19	26	593.859
#448	OVOL1	7	22	29	416.175
#449	PAX4	7	23	30	634.654
#450	STAT1	7	22	29	437.643
#451	HOXC8	7	28	35	1190.302
#452	HOXB6	7	19	26	315.636
#453	GSX1	7	24	31	765.484
#454	YBX1	7	18	25	469.382
#455	TEF	7	16	23	638.63
#456	LCOR	7	23	30	668.109
#457	NFATC3	7	24	31	830.678
#458	NOTCH1	7	23	30	733.821
#459	ZKSCAN3	7	23	30	443.32
#460	ERG	6	23	29	462.951
#461	SOX4	6	29	35	574.004
#462	ZNF483	6	20	26	460.83
#463	ETV6	6	25	31	632.004
#464	ZNF167	6	22	28	672.514
#465	LZTS1	6	21	27	394.704
#466	MEIS2	6	18	24	290.37
#467	MITF	6	32	38	815.684
#468	FOXO3	6	20	26	574.48
#469	GATA4	6	21	27	348.936
#470	RUNX1	6	19	25	445.408
#471	ZEB2	5	21	26	387.876
#472	GLI2	5	21	26	693.968
#473	ZKSCAN2	5	27	32	674.276
#474	MGA	5	24	29	390.067
#475	GATA2	5	27	32	524.254
#476	MAFK	5	25	30	414.153
#477	HOXC10	5	22	27	287.567
#478	VDR	5	31	36	448.43
#479	ALX3	5	29	34	692.738
#480	ZSCAN20	5	26	31	716.254
#481	TP73	5	26	31	440.011
#482	ZFPM2	5	26	31	281.513
#483	POU4F3	5	26	31	703.976
#484	CREB5	5	23	28	374.022
#485	POU4F1	5	26	31	617.851
#486	ZIC5	5	30	35	488.421
#487	KLF16	4	25	29	364.657
#488	HIF3A	4	24	28	416.465
#489	ETS2	4	32	36	1431.488
#490	LHX2	4	25	29	460.554
#491	TBX19	4	21	25	264.224
#492	ATF5	4	25	29	496.804
#493	SREBF2	4	21	25	339.712
#494	MTA2	3	21	24	167.382
#495	SALL2	3	26	29	449.377
#496	EMX1	3	27	30	291.121
#497	LASS5	3	28	31	399.387
#498	TAF5L	2	29	31	311.985
#499	SIX4	2	21	23	167.73
#500	ISX	1	24	25	139.247