Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	HCLS1	56	1	57	1067.297
#2	SCML2	52	3	55	1973.108
#3	IRF8	51	2	53	68.957
#4	KLF2	49	7	56	2673.284
#5	MAF	46	7	53	1154.354
#6	MYT1L	44	5	49	772.847
#7	MYT1	43	10	53	2128.494
#8	NOTCH1	42	8	50	1296.768
#9	ZNF135	41	7	48	947.995
#10	ZSCAN2	40	2	42	562.454
#11	MEF2C	40	5	45	1214.441
#12	HNRNPK	38	3	41	330.358
#13	E2F1	37	3	40	276.723
#14	POU2F2	37	11	48	4128.171
#15	CNBP	36	8	44	4104.461
#16	PCGF6	36	9	45	639.964
#17	CEBPD	35	9	44	3069.714
#18	IRF9	34	6	40	407.817
#19	UHRF1	34	3	37	179.13
#20	TEAD2	33	11	44	5701.14
#21	RCAN1	32	6	38	1208.687
#22	MYCN	31	8	39	455.944
#23	NOLC1	31	6	37	982.165
#24	CSDA	30	13	43	1839.538
#25	HOXB7	30	4	34	407.82
#26	STAT2	30	9	39	3790.765
#27	TGIF2	30	12	42	1825.697
#28	TFDP2	29	8	37	723.606
#29	TAF5	29	7	36	633.246
#30	FUBP1	28	11	39	10694.475
#31	NFYA	28	7	35	896.787
#32	FOXS1	28	9	37	4109.031
#33	E2F7	28	8	36	1137.331
#34	YEATS4	28	8	36	722.037
#35	TRIM22	28	4	32	760.579
#36	TCF3	27	6	33	609.024
#37	KLF6	27	5	32	10190.582
#38	E2F8	27	4	31	701.93
#39	RAX2	26	6	32	754.641
#40	BHLHE40	26	6	32	746.545
#41	ETV4	26	14	40	2786.89
#42	SOX13	26	5	31	139.529
#43	GATA3	26	9	35	1884.061
#44	E2F3	26	4	30	402.475
#45	ZNF193	26	7	33	1155.076
#46	IRF1	26	7	33	3354.62
#47	POU2F1	25	9	34	2837.391
#48	EGR2	25	2	27	99.675
#49	ZHX2	25	9	34	2793.171
#50	PTTG1	25	5	30	350.225
#51	SIX4	25	8	33	3960.722
#52	FOXO3	25	15	40	3643.967
#53	HEYL	25	9	34	593.017
#54	HOXA4	24	3	27	2935.407
#55	CITED1	24	11	35	2714.059
#56	ZKSCAN2	24	6	30	734.602
#57	MTA3	24	11	35	884.566
#58	ZC3H8	24	11	35	1469.341
#59	SOX12	23	7	30	876.67
#60	ISL1	23	11	34	3046.722
#61	GABPB1	23	7	30	769.207
#62	RUNX2	23	15	38	7618.142
#63	NR2C1	23	8	31	376.799
#64	HOXA5	23	7	30	4712.018
#65	ZNF3	22	7	29	442.264
#66	RCOR2	22	8	30	1422.259
#67	GLI2	22	10	32	600.385
#68	TAF5L	22	8	30	1839.369
#69	ELF1	22	6	28	229.71
#70	PA2G4	22	9	31	307.78
#71	HNRNPAB	21	5	26	820.684
#72	SPI1	21	6	27	349.992
#73	E2F2	21	5	26	2388.252
#74	ZNF217	20	15	35	2477.694
#75	CREB3L4	20	10	30	1758.751
#76	TCF12	20	13	33	1311.961
#77	HOXA2	20	5	25	155.92
#78	HOXB8	20	4	24	172.519
#79	TLX2	20	10	30	1661.111
#80	ZFHX3	20	16	36	5955.341
#81	RFXAP	20	7	27	2013.018
#82	FOXO1	19	10	29	2103.795
#83	NFE2L2	19	5	24	165.044
#84	BCL6	19	12	31	2582.889
#85	JUN	19	10	29	1871.388
#86	KLF12	19	15	34	1331.874
#87	ZNF33B	19	7	26	408.578
#88	HDAC2	19	5	24	912.304
#89	EBF1	19	9	28	1077.346
#90	BCL3	19	9	28	1195.242
#91	ZNF45	18	8	26	1857.697
#92	TFAP4	18	8	26	230.514
#93	GABPA	18	3	21	247.701
#94	SOX4	18	13	31	1132.815
#95	NFIC	18	8	26	763.182
#96	PKNOX1	17	8	25	1222.476
#97	SIX5	17	12	29	797.856
#98	PHOX2B	17	12	29	11384.208
#99	TGIF1	17	11	28	2137.395
#100	MAFB	17	15	32	1400.686
#101	KLF9	17	8	25	724.542
#102	HIF1A	17	13	30	5716.587
#103	HSF2	17	6	23	370.333
#104	STAT4	17	12	29	4480.435
#105	ELF4	17	11	28	1875.066
#106	AHR	16	10	26	1096.611
#107	PLAGL2	16	9	25	633.696
#108	NFKB1	16	9	25	1043.24
#109	NFXL1	16	7	23	468.452
#110	PKNOX2	16	8	24	2102.163
#111	HMGB2	16	8	24	447.855
#112	ZNF91	16	10	26	1328.842
#113	TSC22D3	16	6	22	1256.365
#114	FOXM1	16	4	20	320.902
#115	C5orf41	16	9	25	1808.641
#116	SMAD6	16	9	25	1459.676
#117	CREB3L2	15	14	29	1070.677
#118	RXRB	15	12	27	1501.324
#119	ZSCAN16	15	11	26	3059.754
#120	AEBP1	15	11	26	431.007
#121	PRRX1	15	15	30	17129.886
#122	HOXD3	15	9	24	956.786
#123	CTCF	15	8	23	682.811
#124	GCFC1	15	4	19	178.806
#125	GTF2I	14	8	22	355.406
#126	BLZF1	14	14	28	4813.721
#127	RUNX3	14	7	21	5412.963
#128	ZFP36L1	14	15	29	1655.645
#129	ATF1	14	8	22	703.073
#130	ECSIT	14	11	25	5783.078
#131	LHX2	14	10	24	4387.308
#132	SOX17	14	10	24	847.948
#133	GATAD2A	14	12	26	969.698
#134	SMAD3	14	13	27	962.519
#135	LASS5	14	15	29	2085.429
#136	ZSCAN18	14	14	28	1448.756
#137	CTBP1	14	7	21	194.904
#138	MZF1	14	8	22	2078.769
#139	HOXB5	14	8	22	1256.038
#140	SOX8	13	16	29	2715.001
#141	FOS	13	4	17	235.094
#142	NR1H3	13	6	19	1940.35
#143	NR1H2	13	16	29	1195.275
#144	ESRRG	13	9	22	2938.5
#145	ZFP90	13	6	19	438.4
#146	CNOT7	13	11	24	1524.965
#147	PURA	13	15	28	723.872
#148	KLF11	13	9	22	955.812
#149	SCRT2	13	11	24	3481.368
#150	GLI3	13	11	24	1181.402
#151	ZNF167	13	11	24	10238.237
#152	NFIX	13	11	24	11716.935
#153	NFIB	13	16	29	12275.594
#154	CSRNP1	13	7	20	382.476
#155	ZNF397	13	13	26	1735.155
#156	TSHZ2	13	10	23	1198.674
#157	STAT6	13	12	25	660.357
#158	ETS1	13	11	24	734.592
#159	RERE	13	11	24	1099.736
#160	LCOR	13	16	29	1343.199
#161	ZIC2	13	13	26	2324.356
#162	HCFC1	12	10	22	842.58
#163	ZNF83	12	11	23	1382.096
#164	ZNF155	12	12	24	3602.03
#165	ONECUT2	12	10	22	515.102
#166	ZNF133	12	8	20	4153.08
#167	FOXJ2	12	11	23	1546.923
#168	ZNF256	12	11	23	610.937
#169	SP4	12	8	20	941.331
#170	SMAD4	12	14	26	4137.164
#171	TAF1B	12	13	25	976.921
#172	TAF12	12	13	25	1708.219
#173	HOXC6	12	9	21	1986.817
#174	E2F6	12	11	23	346.331
#175	FOXD2	12	11	23	7174.227
#176	IRF3	12	9	21	1511.592
#177	GAS7	12	12	24	1564.723
#178	TFAP2B	12	11	23	833.697
#179	ARNT2	12	18	30	4628.708
#180	NEUROD1	12	8	20	1180.52
#181	HOXC4	11	11	22	1621.878
#182	SIM2	11	4	15	385.742
#183	RUNX1T1	11	12	23	687.099
#184	SMAD9	11	15	26	1007.239
#185	EGR1	11	6	17	482.885
#186	STAT3	11	13	24	1302.841
#187	TCF25	11	12	23	954.951
#188	E2F5	11	14	25	1074.047
#189	PRDM1	11	9	20	1020.1
#190	RORA	11	13	24	1218.114
#191	TULP4	11	11	22	1606.88
#192	HOXB2	11	7	18	5140.643
#193	STAT5A	11	8	19	271.576
#194	SIX1	11	3	14	234.534
#195	SOX15	11	16	27	670.832
#196	PHF5A	11	7	18	318.179
#197	FOXD1	10	11	21	1037.644
#198	FOSB	10	6	16	131.084
#199	PHOX2A	10	10	20	7966.856
#200	HMX1	10	11	21	3586.389
#201	HOXD10	10	13	23	3105.93
#202	E2F4	10	17	27	2012.949
#203	CSRNP2	10	13	23	1542.039
#204	HHEX	10	10	20	732.087
#205	RFXANK	10	13	23	600.03
#206	MNX1	10	11	21	1801.171
#207	ZNF148	10	13	23	1523.697
#208	RBCK1	10	9	19	488.165
#209	C1orf85	10	18	28	1810.577
#210	TFAM	10	11	21	544.732
#211	XBP1	10	8	18	395.007
#212	TMEM229A	10	13	23	2947.563
#213	NFKB2	10	6	16	204.563
#214	SP3	10	6	16	2698.976
#215	TSC22D2	10	8	18	1528.869
#216	TEAD4	10	16	26	3528.426
#217	MYC	10	14	24	2864.792
#218	SPEN	10	7	17	1324.974
#219	MXD1	10	14	24	2857.005
#220	HDAC1	9	18	27	3863.197
#221	GATA2	9	9	18	357.314
#222	HOXD11	9	12	21	7823.794
#223	SOX11	9	15	24	1371.212
#224	ZEB2	9	11	20	1275.501
#225	ETV5	9	12	21	3087.931
#226	HEY1	9	15	24	1904.862
#227	RUNX1	9	11	20	771.245
#228	POU4F1	9	16	25	4388.917
#229	BTG2	9	8	17	199.459
#230	IRX5	9	14	23	1312.215
#231	PLSCR1	9	13	22	976.354
#232	LHX8	9	16	25	5162.419
#233	TRIM28	9	12	21	516.758
#234	ARID3A	9	14	23	1008.485
#235	HOXA10	9	7	16	1990.198
#236	RB1	9	10	19	3434.431
#237	LASS6	9	13	22	1709.161
#238	ZNF238	9	11	20	1006.809
#239	GTF2H3	9	11	20	1059.998
#240	FOXR2	9	7	16	1554.807
#241	HINFP	9	7	16	698.406
#242	SP140	9	5	14	273.886
#243	CNOT8	9	11	20	1455.952
#244	STRN3	9	7	16	456.324
#245	ZBTB17	9	9	18	373.587
#246	TAF7	9	16	25	1215.527
#247	ZSCAN21	9	11	20	6641.816
#248	MNT	9	17	26	1923.131
#249	ETV1	9	13	22	1971.914
#250	ELF2	9	10	19	2292.787
#251	IRX1	9	8	17	3020.682
#252	NFIL3	8	7	15	454.226
#253	NR2C2	8	11	19	2036.719
#254	FLI1	8	11	19	327.183
#255	BHLHE41	8	18	26	1275.031
#256	FBXW7	8	12	20	5947.078
#257	ZNF187	8	12	20	6028.969
#258	MEIS3	8	14	22	2261.938
#259	TP53	8	13	21	368.345
#260	ZNF438	8	14	22	1294.766
#261	KLF4	8	7	15	4973.315
#262	SOX18	8	9	17	1530.838
#263	ZXDA	8	9	17	3425.518
#264	NR4A2	8	10	18	1148.615
#265	RELB	8	7	15	262.451
#266	HOXA9	8	8	16	674.26
#267	TADA3	8	7	15	1643.348
#268	NR5A1	8	9	17	659.875
#269	HEY2	8	9	17	818.632
#270	EOMES	8	7	15	688.605
#271	ZNF202	8	10	18	529.678
#272	ZBTB48	8	16	24	1189.589
#273	IRF7	8	7	15	457.969
#274	ZFP37	8	13	21	666.274
#275	TFDP1	8	8	16	476.218
#276	ATF6	8	15	23	440.563
#277	HOXD9	8	9	17	2091.022
#278	ETV3	7	11	18	989.921
#279	NPAT	7	12	19	827.489
#280	TCF7L2	7	13	20	691.19
#281	ADNP	7	12	19	566.02
#282	HOXD4	7	9	16	3633.334
#283	MSC	7	9	16	320.909
#284	HMX2	7	14	21	1770.166
#285	NKX3-1	7	15	22	6430.497
#286	TFCP2	7	15	22	1166.901
#287	SNAPC2	7	14	21	619.404
#288	EPAS1	7	8	15	1884.6
#289	SATB2	7	16	23	2419.916
#290	MYOD1	7	8	15	1820.355
#291	CEBPB	7	11	18	382.085
#292	TCF21	7	10	17	143.716
#293	MLLT10	7	11	18	473
#294	NKX3-2	7	9	16	3033.918
#295	HSF1	7	11	18	1403.723
#296	SALL2	7	11	18	3343.641
#297	PBX3	7	12	19	144.746
#298	STAT1	7	10	17	354.324
#299	SCML1	7	14	21	348.179
#300	RFX1	7	7	14	907.931
#301	ATF2	7	9	16	344.523
#302	MEIS1	7	11	18	1348.705
#303	THRA	7	12	19	509.987
#304	ZKSCAN1	6	14	20	837.471
#305	PCGF2	6	11	17	1000.549
#306	SLC2A4RG	6	10	16	1021.909
#307	AHCTF1	6	10	16	919.703
#308	CREB1	6	9	15	1546.544
#309	GATAD2B	6	20	26	2953.351
#310	ZNF69	6	11	17	484.701
#311	ATF4	6	14	20	880.907
#312	MAFG	6	15	21	3769.12
#313	JUND	6	11	17	994.346
#314	ELK1	6	10	16	310.293
#315	CREBZF	6	13	19	2835.879
#316	RBPJ	6	14	20	221.681
#317	CBFA2T3	6	13	19	509.209
#318	ZIC3	6	11	17	1013.038
#319	TAF4	6	13	19	998.957
#320	GTF2IRD1	6	11	17	1117.086
#321	ADNP2	6	12	18	1470.254
#322	ZNF35	6	11	17	1276.624
#323	NPAS1	6	17	23	4751.447
#324	SIX2	6	10	16	1163.092
#325	NFYB	6	16	22	914.435
#326	HAND1	6	15	21	2256.995
#327	ZNF189	6	10	16	1245.687
#328	TSC22D4	6	14	20	953.914
#329	ALX1	5	12	17	873.052
#330	NME2	5	13	18	122.982
#331	ELF3	5	11	16	469.511
#332	FOXF1	5	12	17	16696.461
#333	TAF10	5	12	17	1234.591
#334	LZTR1	5	9	14	192.374
#335	LHX6	5	15	20	1549.438
#336	SATB1	5	15	20	3580.611
#337	PBX2	5	8	13	2437.011
#338	SOX10	5	8	13	257.179
#339	OLIG2	5	5	10	550.713
#340	DLX1	5	16	21	1563.793
#341	TWIST1	5	19	24	3780.49
#342	MYNN	5	12	17	331.555
#343	RFX5	5	11	16	433.421
#344	ZNF232	5	13	18	1784.727
#345	KLF10	5	15	20	854.989
#346	PEG3	5	17	22	397.296
#347	CEBPA	5	7	12	321.427
#348	ATF3	5	8	13	136.817
#349	CBFA2T2	5	9	14	2340.877
#350	CBFB	5	18	23	4231.052
#351	SLC30A9	5	21	26	1947.973
#352	USF2	5	11	16	1098.701
#353	ESRRA	5	9	14	233.013
#354	MECOM	5	19	24	7750.052
#355	RNF4	5	10	15	249.735
#356	LBX2	5	16	21	903.881
#357	PHTF1	5	13	18	1570.553
#358	CTNNB1	5	10	15	1478.193
#359	MLL	5	10	15	397.972
#360	SCMH1	5	10	15	134.699
#361	HOXB9	5	6	11	2836.148
#362	SNAPC4	5	10	15	1699.743
#363	ETS2	5	13	18	548.102
#364	BATF3	5	18	23	1983.54
#365	NFX1	5	11	16	1285.747
#366	PROX1	4	16	20	1851.654
#367	ZFPM1	4	12	16	457.109
#368	HOPX	4	14	18	270.007
#369	ZFP42	4	10	14	375.867
#370	TSC22D1	4	14	18	1143.188
#371	MSX1	4	14	18	1263.613
#372	TARDBP	4	16	20	600.134
#373	FOXD4L1	4	10	14	581.863
#374	SOX9	4	11	15	507.36
#375	LEF1	4	13	17	224.539
#376	HOXD13	4	8	12	458.162
#377	TCFL5	4	15	19	156.825
#378	FOXD4L5	4	7	11	433.521
#379	CREB5	4	15	19	624.985
#380	HOMEZ	4	16	20	621.139
#381	ZRANB2	4	14	18	1396.994
#382	TBX3	4	18	22	599.151
#383	MEOX1	4	14	18	681.989
#384	STAT5B	4	8	12	809.106
#385	SRF	4	20	24	3256.647
#386	SUPT4H1	4	12	16	646.895
#387	FOSL1	4	12	16	382.016
#388	WNT5A	4	16	20	863.11
#389	REXO4	4	8	12	5029.99
#390	HOXC8	4	9	13	1333.585
#391	CUX2	4	12	16	302.046
#392	FOXC1	4	18	22	5138.793
#393	ASCL1	4	20	24	888.928
#394	CDKN2A	4	12	16	2921.544
#395	TBP	4	13	17	1256.752
#396	POU4F2	4	13	17	277.677
#397	PPARD	4	18	22	1639.691
#398	NFATC1	4	10	14	1658.878
#399	BTAF1	4	10	14	2052.296
#400	PURB	4	17	21	4180.291
#401	NFIA	4	17	21	2696.503
#402	DMTF1	4	17	21	696.633
#403	DLX3	4	10	14	614.623
#404	HES6	4	11	15	122.38
#405	IKZF1	4	5	9	144.167
#406	FOXN2	4	13	17	3475.175
#407	NR2F2	3	13	16	1189.938
#408	SCAND1	3	10	13	904.622
#409	HMBOX1	3	21	24	3146.56
#410	NFE2L1	3	12	15	115.13
#411	BACH2	3	11	14	346.871
#412	CCRN4L	3	13	16	693.822
#413	DRAP1	3	12	15	164.976
#414	FOXD4L4	3	10	13	2898.694
#415	NR1D2	3	13	16	695.798
#416	ETV6	3	8	11	130.951
#417	FOXJ3	3	12	15	2024.482
#418	HMG20A	3	8	11	511.961
#419	RORB	3	18	21	4014.021
#420	PPARG	3	16	19	2036.412
#421	ZFPM2	3	19	22	2467.334
#422	KDM5B	3	13	16	2086.11
#423	ENO1	3	9	12	140.601
#424	AFF4	3	9	12	131.481
#425	FOXN4	3	16	19	229.25
#426	HES1	3	17	20	2245.884
#427	TCF4	3	15	18	1738.293
#428	FOXA2	3	10	13	649.173
#429	ATF5	3	19	22	890.427
#430	EDF1	3	11	14	850.886
#431	TCEAL1	3	16	19	6130.03
#432	TAF4B	3	15	18	734.674
#433	SOX7	3	13	16	621.196
#434	ZNF323	3	16	19	2196.976
#435	PRRX2	3	16	19	2457.624
#436	RXRA	3	10	13	4184.379
#437	IRF6	3	11	14	4740.724
#438	IRX2	2	4	6	8.692
#439	SIX6	2	9	11	1866.378
#440	MEOX2	2	14	16	1500.393
#441	WT1	2	6	8	117.03
#442	LMO4	2	15	17	1174.861
#443	NR2F1	2	18	20	1233.963
#444	FOXP1	2	15	17	317.079
#445	TBX2	2	20	22	836.38
#446	RARB	2	12	14	54.24
#447	HOXD8	2	10	12	180.539
#448	ZNF281	2	11	13	570.728
#449	ZNF277	2	15	17	115.624
#450	TSHZ1	2	16	18	504.587
#451	POU3F2	2	16	18	761.548
#452	AATF	2	10	12	63.603
#453	TSHZ3	2	19	21	116.602
#454	RARA	2	15	17	2953.62
#455	MSRB2	2	15	17	168.11
#456	SNAI2	2	16	18	195.5
#457	ASCL2	2	10	12	127.056
#458	LZTS1	2	13	15	1704.531
#459	HOXC9	2	16	18	255.087
#460	FEV	2	18	20	1710.454
#461	MTA1	2	13	15	3041.008
#462	SIX3	2	15	17	829.819
#463	TFAP2A	2	10	12	561.588
#464	CSRNP3	2	19	21	1572.459
#465	USF1	1	16	17	102.665
#466	PBX4	1	12	13	96.985
#467	ZFHX4	1	13	14	704.037
#468	MEIS2	1	15	16	2184.147
#469	VTN	1	12	13	64.558
#470	ZNF274	1	11	12	593.024
#471	NR4A3	1	13	14	64.762
#472	IRX6	1	17	18	93.854
#473	CLOCK	1	9	10	542.656
#474	HOXD1	1	14	15	2454.643
#475	HES5	1	9	10	64.52
#476	SREBF1	1	15	16	318.453
#477	TEF	1	13	14	84.466
#478	CITED2	1	16	17	322.174
#479	MKX	1	13	14	1704.362
#480	NR2F6	1	11	12	2342.15
#481	NFE2L3	1	16	17	151.763
#482	MSL3	1	13	14	159.846
#483	SREBF2	1	13	14	45.929
#484	BCL11B	1	21	22	1482.394
#485	PAX8	1	7	8	56.719
#486	FOXO4	1	11	12	152.043
#487	TBX1	1	19	20	195.524
#488	BUD31	1	14	15	1167.653
#489	ZNF134	1	13	14	75
#490	ARNTL	1	15	16	742.992
#491	ZNF219	1	15	16	152.821
#492	VAX2	0	10	10	0
#493	DDIT3	0	13	13	0
#494	ST18	0	9	9	0
#495	NKX6-2	0	12	12	0
#496	IRX3	0	16	16	0
#497	MESP1	0	16	16	0
#498	KCNH8	0	12	12	0
#499	SP1	0	12	12	0
#500	MEF2D	0	13	13	0