Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	HDAC1	125	2	127	56.612
#2	YBX1	110	10	120	788.167
#3	TRIM28	97	6	103	380.517
#4	PLSCR1	95	12	107	3326.562
#5	NR2C2	93	4	97	274.472
#6	HMG20B	90	7	97	537.597
#7	RBPJ	89	13	102	323.129
#8	BUD31	88	8	96	900.914
#9	HIRA	85	12	97	10329.574
#10	CNOT8	84	9	93	856.279
#11	ATF2	80	4	84	134.556
#12	ZNF639	79	9	88	986.55
#13	ATF1	77	5	82	3837.04
#14	MLLT10	76	8	84	422.742
#15	STAT3	75	11	86	527.697
#16	MLX	73	15	88	598.311
#17	MYC	72	14	86	770.52
#18	ZGPAT	71	16	87	8169.583
#19	RFXANK	68	9	77	187.657
#20	SIN3A	67	17	84	667.691
#21	TADA3	66	10	76	207.341
#22	ZNF445	66	17	83	630.483
#23	ZFP90	65	15	80	788.905
#24	CTBP1	65	5	70	720.98
#25	NFYC	64	9	73	277.95
#26	ECSIT	64	14	78	305.453
#27	CREBBP	63	10	73	947.996
#28	AATF	63	12	75	827.434
#29	TAF7	63	6	69	96.305
#30	MEF2A	62	13	75	375.408
#31	HCLS1	61	13	74	358.552
#32	RNF4	61	9	70	117.213
#33	MAX	59	10	69	362.787
#34	MGA	57	13	70	321.75
#35	SUPT6H	56	11	67	720.353
#36	RFX5	56	12	68	333.896
#37	ZRANB2	54	10	64	424.849
#38	HMGB2	54	9	63	2118.515
#39	EDF1	53	11	64	161.57
#40	ENO1	53	15	68	285.953
#41	TAF12	52	14	66	522.59
#42	DRAP1	51	14	65	433.884
#43	ARNTL	51	17	68	2365.065
#44	GTF2H4	50	13	63	853.407
#45	TSHZ1	50	14	64	411.396
#46	CBFB	48	16	64	433.746
#47	HEY1	48	17	65	1676.449
#48	ELF1	48	19	67	366.4
#49	CREM	48	16	64	2372.016
#50	ZNF33A	48	8	56	530.153
#51	TCFL5	47	14	61	297.651
#52	ELF4	46	16	62	6090.165
#53	C5orf41	45	22	67	1112.78
#54	ZNF277	45	21	66	2202.001
#55	ZNF131	45	23	68	1761.645
#56	NFYB	45	17	62	649.037
#57	TCF4	44	7	51	333.278
#58	TFE3	44	15	59	169.951
#59	NFE2L2	44	21	65	722.37
#60	MSRB2	43	18	61	464.402
#61	CREB3	43	16	59	530.565
#62	KLF3	43	16	59	5506.856
#63	ZEB2	43	22	65	5606.967
#64	ETS1	42	19	61	1406.597
#65	ZBTB38	41	12	53	155.715
#66	NFATC3	41	25	66	513.945
#67	CSDA	41	16	57	579.846
#68	MAFB	40	9	49	4772.478
#69	KLF6	40	20	60	263.275
#70	NR3C1	40	17	57	540.969
#71	RELA	40	14	54	635.281
#72	TCF3	39	8	47	261.35
#73	ZNF83	39	19	58	597.05
#74	CREB1	39	13	52	595.278
#75	NFIB	39	8	47	546.99
#76	TCF7L2	39	17	56	2072.093
#77	CEBPD	39	14	53	17148.436
#78	MITF	39	12	51	1785.024
#79	CEBPB	38	28	66	1124.719
#80	SCML1	38	19	57	2405.101
#81	IRF3	37	17	54	1439.009
#82	SUPT4H1	37	20	57	450
#83	LEF1	37	21	58	2052.626
#84	ZNF394	37	17	54	481.603
#85	RXRB	37	15	52	414.325
#86	TFDP2	36	20	56	4208.219
#87	ZHX2	36	15	51	453.257
#88	REL	36	19	55	1113.3
#89	FLI1	36	13	49	195.655
#90	STAT1	36	17	53	919.147
#91	STAT6	35	17	52	582.999
#92	RBCK1	35	18	53	1384.119
#93	GTF2I	35	8	43	121.297
#94	HNRNPAB	35	20	55	1670.83
#95	EBF1	35	13	48	923.197
#96	TFCP2	34	19	53	3539.408
#97	HSF1	34	15	49	624.014
#98	ZFP36L2	34	15	49	766.862
#99	GABPB1	34	17	51	1109.977
#100	ZNF207	34	22	56	998.026
#101	PURA	33	16	49	856.347
#102	GTF2H2	33	17	50	779.994
#103	JUND	33	17	50	2809.561
#104	ZNF3	32	22	54	788.858
#105	TEAD1	31	15	46	589.084
#106	TFDP1	31	15	46	160.038
#107	NFYA	31	20	51	557.126
#108	PBX1	31	15	46	892.942
#109	IRF7	31	17	48	534.849
#110	MEF2C	30	17	47	631.558
#111	ZNF45	30	18	48	818.928
#112	ZXDC	30	23	53	974.807
#113	PRRX1	30	13	43	803.575
#114	NPAT	30	7	37	70.847
#115	RUNX1	29	22	51	404.304
#116	SNAI2	29	15	44	1070.084
#117	ZBTB48	29	16	45	326.083
#118	IKZF1	29	14	43	301.764
#119	GATAD1	29	21	50	7032.372
#120	MECOM	29	25	54	2967.915
#121	ZFP36L1	29	22	51	1358.972
#122	LASS2	28	26	54	495.654
#123	GATA3	28	23	51	1146.052
#124	LASS6	28	19	47	1127.59
#125	ATF3	28	25	53	3056.618
#126	JUNB	28	22	50	1217.766
#127	IRF1	27	14	41	1549.533
#128	SP1	27	16	43	223.468
#129	NR2F2	27	9	36	358.82
#130	SMAD1	27	11	38	2395.57
#131	WNT5A	27	20	47	3561.418
#132	NR1D2	27	19	46	332.524
#133	ELK3	26	16	42	676.771
#134	FOXO1	26	25	51	4003.41
#135	ATF6	25	18	43	2884.303
#136	MAF	25	24	49	1571.815
#137	IRF2	25	19	44	1897.522
#138	SPDEF	25	20	45	517.175
#139	EPAS1	25	23	48	2686.673
#140	FOXQ1	25	15	40	1249.155
#141	RELB	24	21	45	386.567
#142	NEUROD1	24	17	41	1670.946
#143	KLF4	23	17	40	1091.406
#144	HMGB1	23	9	32	46.231
#145	POU2F2	23	17	40	1057.175
#146	BACH2	23	22	45	2500.732
#147	NR2F1	23	19	42	2369.411
#148	ZNF93	23	20	43	7445.331
#149	ZFP42	23	18	41	1420.152
#150	RARB	22	16	38	292.947
#151	FOXK1	22	16	38	1094.667
#152	RAX2	22	16	38	2560.488
#153	FOXN3	22	20	42	334.327
#154	UHRF1	22	24	46	2703.199
#155	NR2F6	22	22	44	558.951
#156	TULP4	22	25	47	1210.248
#157	KLF9	21	20	41	1280.524
#158	POU4F2	21	19	40	1029.91
#159	SIX5	21	24	45	3249.47
#160	CITED2	21	19	40	1224.185
#161	RUNX1T1	21	20	41	374.15
#162	EHF	21	21	42	1222.629
#163	SCAND1	20	15	35	93.754
#164	ZNF287	20	17	37	4163.441
#165	NFX1	20	21	41	1440.643
#166	ISL1	20	13	33	730.651
#167	E2F4	20	24	44	461.567
#168	HOPX	20	20	40	1708.493
#169	AEBP1	19	19	38	1333.944
#170	SMAD3	19	15	34	607.315
#171	JUN	19	15	34	581.131
#172	ZNF628	19	16	35	9008.619
#173	AHCTF1	19	16	35	2776.01
#174	ETV1	19	19	38	1806.497
#175	NR1H3	19	19	38	2026.665
#176	MEOX2	19	15	34	984.199
#177	SMAD4	19	22	41	2079.615
#178	GLIS3	18	20	38	665.691
#179	FOSL2	18	25	43	1964.439
#180	IRF4	18	23	41	612.382
#181	SALL1	18	21	39	4269.784
#182	FOXF1	18	19	37	6749.495
#183	ZNF91	18	16	34	285.125
#184	JDP2	18	17	35	659.507
#185	FOXM1	18	18	36	263.764
#186	ARID4A	18	19	37	145.319
#187	EGR2	18	23	41	2198.31
#188	HOXA5	18	24	42	1183.278
#189	NR1H4	17	16	33	10633.75
#190	SATB1	17	21	38	11803.823
#191	RUNX2	17	23	40	6722.765
#192	FOXC1	17	18	35	1964.832
#193	GATA6	17	20	37	411.41
#194	ZFHX4	17	21	38	2492.42
#195	ZKSCAN1	16	15	31	377.032
#196	MBD1	16	21	37	221.133
#197	PHOX2B	16	19	35	12999.55
#198	ESRRB	16	24	40	345.106
#199	FOS	16	19	35	1281.832
#200	FOXR2	16	19	35	759.988
#201	HOXC10	16	19	35	2622.609
#202	CEBPA	16	21	37	2785.902
#203	NFIA	15	28	43	668.208
#204	PBX4	15	20	35	2934.623
#205	SIM1	15	24	39	6815.242
#206	HOXB9	15	24	39	198.199
#207	E2F8	15	20	35	5574.76
#208	ZNF140	15	21	36	1280.512
#209	NOBOX	15	19	34	2795.08
#210	SLC26A3	14	17	31	171.018
#211	BATF3	14	19	33	5640.305
#212	BTG2	14	18	32	304.777
#213	ARNT2	14	16	30	531.926
#214	MYF5	14	25	39	643.128
#215	BHLHE41	14	15	29	113.936
#216	SOX6	14	20	34	338.308
#217	PKNOX2	14	16	30	1206.525
#218	VAX2	14	19	33	1539.366
#219	HOXA1	14	24	38	998.787
#220	TEAD4	14	20	34	1500.801
#221	MSX1	14	25	39	733.933
#222	SPEN	13	18	31	1302.427
#223	ZSCAN18	13	19	32	544.257
#224	ZFPM1	13	17	30	624.285
#225	BHLHE40	13	19	32	678.058
#226	ELF3	13	21	34	324.233
#227	EGR1	13	20	33	1324.676
#228	ZNF496	13	22	35	1721.826
#229	AHR	13	22	35	1199.656
#230	PURB	13	19	32	1578.672
#231	HOXD1	13	19	32	1794.837
#232	RORA	13	23	36	411.832
#233	ARNTL2	13	27	40	2238.555
#234	ZSCAN1	13	23	36	1297.286
#235	HNF1A	13	14	27	1354.809
#236	MYCN	13	25	38	772.882
#237	BATF	13	19	32	150.408
#238	ST18	13	14	27	6055.893
#239	ELF5	13	24	37	3669.231
#240	MSX2	13	19	32	714.562
#241	SP4	13	19	32	1619.574
#242	VSX1	13	17	30	18616.067
#243	TP53	13	20	33	211.321
#244	HOXA6	13	21	34	3678.9
#245	MTA2	12	19	31	2981.133
#246	ZFPM2	12	23	35	327.433
#247	KLF12	12	21	33	255.012
#248	SIX1	12	22	34	1703.41
#249	ZNF135	12	26	38	2506.592
#250	TBX3	12	23	35	613.959
#251	FOXJ2	12	17	29	342.081
#252	TRERF1	12	24	36	1659.72
#253	HIF3A	12	22	34	5612.356
#254	NANOGNB	12	18	30	3133.346
#255	NR4A2	12	21	33	3186.4
#256	LHX3	12	20	32	1513.906
#257	MYBL2	12	14	26	546.669
#258	ZEB1	12	19	31	354.539
#259	SPIB	11	19	30	687.495
#260	SOX4	11	21	32	1959.872
#261	ETV5	11	22	33	875.109
#262	FUBP1	11	19	30	2581.909
#263	HOXC11	11	16	27	441.136
#264	MLL	11	19	30	396.256
#265	TFAP2B	11	21	32	2276.63
#266	TFAP2D	11	21	32	2035.935
#267	NFIC	11	27	38	4481.503
#268	TBX5	11	22	33	698.976
#269	ATF5	11	25	36	862.424
#270	ZNF483	11	23	34	4327.83
#271	CREBZF	11	25	36	675.416
#272	TFEC	11	27	38	375.199
#273	YY1	10	16	26	182.329
#274	HOXA10	10	19	29	7020.9
#275	ESRRG	10	18	28	6855.615
#276	E2F5	10	19	29	131.253
#277	TSC22D3	10	20	30	947.328
#278	GLI2	10	20	30	1414.43
#279	ARNT	10	20	30	284.275
#280	GRHL2	10	20	30	583.577
#281	ARX	10	26	36	535.781
#282	FOXO3	10	23	33	771.232
#283	IRX5	10	19	29	1272.081
#284	NR4A1	10	20	30	1100.23
#285	MYT1	10	18	28	506.349
#286	MSC	10	26	36	3827.252
#287	RB1	10	25	35	636.944
#288	NFAT5	10	28	38	741.073
#289	ZFHX3	10	16	26	1466.231
#290	L3MBTL4	10	18	28	1408.864
#291	NFIX	9	32	41	1480.359
#292	NANOG	9	19	28	120.515
#293	MAFK	9	16	25	776.749
#294	TCF7	9	23	32	567.718
#295	NKX6-2	9	18	27	1338.609
#296	HOXD10	9	27	36	434.808
#297	MKX	9	20	29	1285.384
#298	MESP2	9	19	28	639.135
#299	BRD8	9	23	32	3721.106
#300	ETV6	9	19	28	322.501
#301	SIM2	9	26	35	4619.762
#302	FOXO6	9	22	31	717.509
#303	CREB3L1	9	25	34	3151.585
#304	HMGA2	9	27	36	2645.957
#305	MMP14	9	18	27	4070.337
#306	ZNF174	9	16	25	902.512
#307	SP140	8	21	29	5714.379
#308	BCL11B	8	18	26	535.2
#309	TGIF1	8	23	31	494.683
#310	PKNOX1	8	18	26	7253.484
#311	IRF6	8	21	29	1512.296
#312	IRX1	8	26	34	1887.96
#313	SOX8	8	21	29	573.016
#314	OLIG2	8	18	26	645.412
#315	LMX1A	8	21	29	728.994
#316	ZNF397	8	16	24	210.907
#317	SOX9	8	26	34	1193.86
#318	DMRT1	8	27	35	7655.655
#319	NPAS1	8	24	32	1077.231
#320	CBFA2T2	8	20	28	388.249
#321	PGR	8	27	35	8130.432
#322	TRIM29	8	21	29	1558.318
#323	ZSCAN20	8	20	28	10042.183
#324	SATB2	8	23	31	722.042
#325	IRX3	8	22	30	636.444
#326	CREB5	8	21	29	744.164
#327	MEOX1	8	25	33	570.253
#328	TEAD2	8	22	30	2375.734
#329	HSF5	8	22	30	2898.554
#330	HES6	7	18	25	297.246
#331	RARA	7	19	26	1742.679
#332	HMGA1	7	16	23	832.366
#333	TWIST1	7	25	32	263.93
#334	STAT5B	7	21	28	1021.218
#335	NFATC2	7	18	25	1541.37
#336	NFATC1	7	19	26	571.11
#337	KLF16	7	17	24	1702.256
#338	NFKB2	7	19	26	739.789
#339	POU3F2	7	25	32	720.796
#340	MESP1	7	23	30	640.608
#341	GAS7	7	22	29	1395.122
#342	CSRNP3	7	24	31	1039.505
#343	LHX1	7	26	33	326.095
#344	SOX13	7	19	26	858.255
#345	HAND1	7	22	29	1629.753
#346	EOMES	7	19	26	2174.26
#347	THRB	7	25	32	1083.848
#348	NR6A1	7	22	29	3467.183
#349	SOX30	7	28	35	3083.024
#350	TWIST2	7	22	29	228.982
#351	TP63	7	28	35	848.265
#352	PPARA	7	21	28	3283.295
#353	NPAS2	6	14	20	872.376
#354	TCF20	6	22	28	917.976
#355	HIC1	6	26	32	1246.125
#356	TFAP2A	6	29	35	3285.198
#357	FOXP2	6	34	40	1380.508
#358	SPI1	6	16	22	803.717
#359	TFAP2C	6	28	34	2311.835
#360	NKX2-1	6	22	28	997.795
#361	ZIC3	6	21	27	1578.474
#362	HOXA2	6	25	31	1014.223
#363	PAX4	6	16	22	203.56
#364	SOX11	6	22	28	216.347
#365	BCL6	6	24	30	204.668
#366	ISL2	6	23	29	99.779
#367	SIX2	6	19	25	392.042
#368	DLX6	6	19	25	681.631
#369	ETV4	6	23	29	837.656
#370	DLX2	6	19	25	1371.583
#371	TBX1	6	21	27	291.928
#372	AFF4	6	21	27	189.497
#373	MEIS1	6	28	34	912.703
#374	PITX1	6	25	31	2006.645
#375	HEY2	6	22	28	1081.854
#376	IRX2	5	21	26	1780.977
#377	MYNN	5	20	25	5754.699
#378	ZNF71	5	17	22	163.603
#379	NR3C2	5	21	26	2740.85
#380	ZNF238	5	19	24	366.6
#381	PBX3	5	19	24	2340.049
#382	FOXE1	5	22	27	169.725
#383	HOXC9	5	19	24	4402.14
#384	EGR4	5	21	26	998.145
#385	E2F2	5	21	26	443.594
#386	HOXD9	5	17	22	1917.946
#387	MYCL1	5	20	25	309.007
#388	ERF	5	21	26	218.681
#389	HOXA9	5	23	28	1926.405
#390	PPARG	5	27	32	1052.934
#391	FOXN4	5	21	26	378.747
#392	ZSCAN10	5	16	21	106.827
#393	PAX8	5	29	34	651.316
#394	FOXA1	5	16	21	1450.284
#395	ZNF80	5	19	24	305.078
#396	RORB	5	27	32	2003.834
#397	HNF1B	5	18	23	80.673
#398	NR0B1	5	27	32	1950.544
#399	TLX2	5	20	25	1637.271
#400	ZNF154	5	22	27	700.683
#401	ZNF449	5	20	25	540.132
#402	IKZF3	5	22	27	559.939
#403	POU4F1	4	28	32	684.299
#404	ZNF193	4	29	33	860.256
#405	MLXIPL	4	16	20	1881.2
#406	DLX1	4	23	27	816.448
#407	ZIC1	4	30	34	634.696
#408	ONECUT1	4	23	27	1734.312
#409	TEF	4	27	31	683.748
#410	ZNF167	4	23	27	1145.416
#411	RFXAP	4	27	31	284.882
#412	SPIC	4	22	26	1837.621
#413	FOSB	4	15	19	890.465
#414	C11orf9	4	22	26	1698.621
#415	ZIC2	4	27	31	3301.276
#416	BATF2	4	17	21	227.478
#417	TBX2	4	27	31	3211.573
#418	FOXG1	4	27	31	937.212
#419	SOX1	4	27	31	1091.095
#420	TP73	4	16	20	1014.724
#421	AR	4	18	22	1255.209
#422	FOXD1	4	23	27	826.111
#423	LZTS1	4	22	26	768.951
#424	PAX7	4	23	27	516.84
#425	ALX1	4	20	24	453.816
#426	GATA5	4	17	21	826.925
#427	WT1	4	28	32	904.967
#428	TSHZ2	4	29	33	818.254
#429	SOX5	4	25	29	1304.445
#430	SOX2	4	28	32	1064.49
#431	SMAD6	3	33	36	1291.534
#432	TLX3	3	19	22	128.352
#433	HOXA11	3	24	27	435.672
#434	HNF4G	3	28	31	374.814
#435	TFDP3	3	19	22	320.85
#436	DMRT2	3	21	24	906.121
#437	RBPJL	3	19	22	614.035
#438	ZNF81	3	24	27	724.853
#439	FOXA3	3	22	25	341.967
#440	ZSCAN23	3	21	24	169.442
#441	NR2E1	3	23	26	6232.935
#442	FOXH1	3	23	26	161.002
#443	ZNF165	3	28	31	185.02
#444	KCNH8	3	16	19	207.277
#445	NR4A3	3	16	19	134.792
#446	VDR	3	17	20	382.048
#447	HOXB7	3	23	26	506.48
#448	ASCL2	3	21	24	953.056
#449	HOXC12	3	21	24	4523.234
#450	NFE2	3	23	26	1898.536
#451	MNX1	3	23	26	789.938
#452	RCOR2	3	22	25	1109.674
#453	ONECUT2	3	28	31	3009.375
#454	MYF6	3	20	23	1284.539
#455	PAX6	3	19	22	1174.054
#456	GRHL3	3	18	21	287.298
#457	BCL3	3	26	29	675.521
#458	ELK4	3	17	20	369.874
#459	TBX6	3	16	19	77.639
#460	TFAP4	3	19	22	60.499
#461	ATF7	3	21	24	1022.107
#462	STRN3	2	23	25	120.752
#463	ISX	2	22	24	1286.044
#464	ESR2	2	19	21	160.54
#465	MYT1L	2	24	26	291.092
#466	NKX2-5	2	28	30	268.635
#467	SIX3	2	26	28	3322.285
#468	NR1I2	2	22	24	1019.616
#469	HLF	2	32	34	1028.785
#470	BARX1	2	25	27	278.344
#471	NFATC4	2	21	23	1627.353
#472	DLX4	2	21	23	323.542
#473	HCFC1	2	20	22	146.191
#474	PROX1	2	24	26	589.705
#475	ASCL1	2	28	30	1438.323
#476	ESR1	2	26	28	378.066
#477	CITED1	2	19	21	418.299
#478	FOXP3	2	24	26	404.492
#479	CUX2	2	21	23	129.572
#480	HOXB1	2	15	17	118.344
#481	NR5A2	2	28	30	300.658
#482	HOXD13	2	27	29	142.796
#483	FOSL1	2	20	22	210.534
#484	RORC	2	25	27	1591.263
#485	SOX10	2	16	18	215.554
#486	SIX4	2	27	29	101.581
#487	VTN	2	22	24	137.969
#488	IRF5	1	19	20	59.54
#489	TFCP2L1	1	24	25	614.255
#490	SCRT1	1	20	21	19.748
#491	NKX2-3	1	26	27	199.431
#492	ERG	1	20	21	39.863
#493	ZNF396	1	17	18	801.309
#494	MTA3	1	25	26	2381.915
#495	GATA4	1	24	25	61.377
#496	LHX2	0	32	32	0
#497	ZNF215	0	32	32	0
#498	FOXP1	0	20	20	0
#499	TADA2A	0	23	23	0
#500	ZNF85	0	18	18	0