Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	TSHZ2	46	4	50	3948.521
#2	ZEB2	41	2	43	358.732
#3	NR3C1	41	6	47	942.986
#4	L3MBTL4	39	8	47	1102.581
#5	SPDEF	39	3	42	1415.11
#6	PTTG1	37	5	42	397.489
#7	FOXM1	37	2	39	629.229
#8	PBX1	36	8	44	1490.912
#9	E2F5	35	7	42	2814.2
#10	EBF1	34	3	37	869.275
#11	NOLC1	33	3	36	363.579
#12	TFAP2A	32	4	36	540.898
#13	ERG	32	2	34	107.219
#14	AHCTF1	32	4	36	473.38
#15	PPARA	31	5	36	1275.474
#16	CREB3L4	31	4	35	456.765
#17	ARNTL2	31	7	38	1401.358
#18	FOXO1	31	6	37	905.827
#19	GATA3	31	8	39	5694.057
#20	GRHL2	30	8	38	619.9
#21	MITF	30	3	33	291.059
#22	ATF3	30	3	33	429.113
#23	SOX9	30	9	39	1030.761
#24	HMG20B	30	7	37	1631.077
#25	E2F2	29	3	32	98.49
#26	ZNF438	29	5	34	1149.524
#27	ESR1	29	1	30	24.253
#28	EPAS1	29	6	35	1823.641
#29	TEAD4	28	5	33	407.058
#30	PLSCR1	28	9	37	2791.358
#31	FOXA1	28	6	34	1353.975
#32	HOXD8	28	4	32	645.74
#33	CEBPB	27	5	32	439.737
#34	NFE2L3	27	6	33	437.454
#35	HOXA3	27	7	34	991.642
#36	ETV6	27	10	37	1996.414
#37	HDAC2	27	8	35	503.939
#38	MAFF	26	8	34	2033.534
#39	FOXN3	26	9	35	2052.955
#40	ZNF37A	26	5	31	598.561
#41	CSRNP1	25	5	30	1286.025
#42	ELF1	25	3	28	367.476
#43	MEIS2	25	14	39	4186.159
#44	TCF19	25	2	27	60.659
#45	PHF1	25	5	30	445.664
#46	RARA	25	9	34	1577.748
#47	MYBL2	25	7	32	1685.757
#48	MAFB	25	7	32	564.703
#49	MECOM	24	5	29	582.561
#50	PEG3	24	15	39	8586.451
#51	CREB3L2	24	11	35	3377.806
#52	RFXAP	24	10	34	2616.247
#53	HIF1A	24	7	31	987.251
#54	SCAND1	23	7	30	1196.18
#55	ESRRG	23	10	33	2399.773
#56	ZFP36L1	23	12	35	1986.274
#57	ZNF91	23	8	31	2360.225
#58	TCF4	23	14	37	2589.552
#59	FOXK2	23	10	33	1392.466
#60	TCEAL1	23	8	31	1376.223
#61	IRF8	23	2	25	570.82
#62	TEAD2	23	9	32	1929.055
#63	ZNF496	22	12	34	1247.196
#64	ZNF138	22	7	29	746.187
#65	TFEC	22	6	28	1755.355
#66	E2F8	22	6	28	461.959
#67	HOXD4	22	5	27	820.998
#68	TFDP1	22	6	28	1262.512
#69	ZIC1	21	7	28	702.346
#70	E2F3	21	12	33	2087.377
#71	YBX1	21	7	28	423.488
#72	IKZF1	21	2	23	2613.283
#73	ZHX1	21	16	37	7060.106
#74	NR4A3	21	8	29	1461.233
#75	FOXP1	21	9	30	723.792
#76	ELK3	21	8	29	1069.863
#77	NR2F6	21	14	35	1945.28
#78	NFIC	21	9	30	1558.549
#79	AHR	21	10	31	1993.374
#80	VAV1	20	5	25	536.728
#81	ZNF238	20	12	32	4311.634
#82	FOXC1	20	14	34	1694.306
#83	NFATC4	20	16	36	4715.399
#84	GAS7	20	15	35	1246.907
#85	HOXA2	20	5	25	716.933
#86	UBN1	20	4	24	1756.906
#87	ZFP36L2	20	9	29	1070.243
#88	ZNF639	20	13	33	3142.55
#89	RUNX1T1	19	11	30	1301.1
#90	HMGA1	19	9	28	1197.999
#91	PCGF2	19	12	31	2801.43
#92	CREBL2	19	9	28	803.657
#93	THRB	19	19	38	4381.5
#94	SMAD9	19	13	32	1468.412
#95	C2orf3	19	9	28	286.3
#96	TBX5	19	7	26	795.673
#97	TCF25	19	10	29	1915.639
#98	SOX7	19	10	29	901.175
#99	KLF5	19	18	37	2177.512
#100	TAF4B	19	19	38	2397.439
#101	HOXC9	19	7	26	2505.363
#102	PRRX1	19	10	29	1944.282
#103	BACH2	18	13	31	655.738
#104	MAF	18	10	28	933.996
#105	ZEB1	18	10	28	1696.355
#106	MZF1	18	9	27	1290.713
#107	HOXC4	18	13	31	3245.432
#108	IRX1	18	13	31	1050.25
#109	FLI1	18	7	25	1382.584
#110	TRIM29	18	13	31	776.194
#111	BRD8	18	10	28	2243.554
#112	YY1	18	11	29	1446.63
#113	EN1	18	10	28	1507.894
#114	NANOG	18	9	27	1936.944
#115	ZNF207	18	5	23	1060.992
#116	SOX17	18	6	24	249.572
#117	ZFHX3	18	14	32	3109.958
#118	MEF2C	18	5	23	105.785
#119	TCF7L1	18	11	29	1285.538
#120	IRX5	18	10	28	559.919
#121	ARID4A	18	9	27	517.49
#122	EGR2	18	6	24	461.428
#123	CSDA	17	11	28	1094.314
#124	ANKRD30A	17	11	28	1377.852
#125	HLF	17	11	28	2684.815
#126	RCAN1	17	12	29	1236.867
#127	IRX3	17	7	24	372.763
#128	SCML1	17	13	30	2090.229
#129	HOXA7	17	10	27	885.919
#130	TBX15	17	10	27	995.537
#131	ETS1	17	11	28	2068.912
#132	SIX5	17	9	26	1092.055
#133	ETS2	17	9	26	883.324
#134	TBX19	17	10	27	1418.535
#135	SUPT4H1	17	12	29	2207.962
#136	SMAD4	16	8	24	656.528
#137	CSRNP3	16	10	26	1461.228
#138	TFAP2C	16	13	29	1284.246
#139	C5orf41	16	10	26	1068.035
#140	TSHZ1	16	16	32	3234.72
#141	MEOX1	16	12	28	711.461
#142	BLZF1	16	9	25	1438.998
#143	ZSCAN16	16	9	25	1030.205
#144	GTF2IRD1	16	9	25	1797.338
#145	NFATC1	16	15	31	1322.329
#146	ZNF148	16	11	27	1901.978
#147	HOXA5	16	6	22	911.166
#148	RUNX3	15	16	31	1303.467
#149	ZFP90	15	6	21	1282.227
#150	NFYB	15	9	24	511.023
#151	PBX2	15	6	21	1122.259
#152	HOXA11	15	8	23	1032.274
#153	MSRB2	15	9	24	1584.041
#154	NR5A2	15	13	28	2993.48
#155	HCLS1	15	11	26	667.356
#156	XBP1	15	9	24	2374.308
#157	ZNF367	15	7	22	365.261
#158	NFIL3	15	13	28	1585.329
#159	RUNX2	15	12	27	1727.424
#160	HMGB1	15	12	27	2490.459
#161	LMO4	15	15	30	1594.263
#162	FUBP1	15	17	32	2343.937
#163	FOXO3	15	12	27	722.232
#164	ZHX3	15	10	25	824.838
#165	STAT5A	15	10	25	2078.042
#166	POU6F1	14	10	24	434.458
#167	BCL6	14	11	25	2231.115
#168	ELF4	14	14	28	2199.654
#169	CBFA2T2	14	9	23	657.636
#170	NR1H2	14	8	22	1975.893
#171	ZNF281	14	16	30	2418.15
#172	LHX6	14	9	23	1211.947
#173	ZNF131	14	10	24	778.116
#174	NR1H3	14	14	28	1129.107
#175	TFE3	14	12	26	1571.803
#176	ZFHX4	14	10	24	2090.856
#177	STAT1	14	16	30	1569.924
#178	CBL	14	6	20	510.141
#179	HOXB5	14	5	19	1413.323
#180	TSHZ3	14	11	25	519.092
#181	ZBTB38	13	9	22	703.434
#182	KLF11	13	17	30	2092.704
#183	YEATS4	13	8	21	574.002
#184	SIX2	13	11	24	2046.69
#185	AFF4	13	13	26	1825.536
#186	KLF9	13	17	30	2448.841
#187	SMAD5	12	15	27	1542.761
#188	BTG2	12	14	26	1071.839
#189	FOSB	12	8	20	488.462
#190	SMAD3	12	19	31	2152.241
#191	TRIM22	12	21	33	2427.255
#192	IRF3	12	10	22	1960.088
#193	EGR3	12	11	23	725.395
#194	CREM	12	9	21	772.936
#195	HOXB7	12	13	25	2846.504
#196	SP140	12	4	16	224.086
#197	CREB5	12	10	22	477.364
#198	GATAD1	12	15	27	1145.018
#199	TP63	12	9	21	760.257
#200	ATF1	12	6	18	1053.772
#201	AEBP1	12	14	26	1765.121
#202	STAT6	12	11	23	900.48
#203	TAF5L	12	7	19	933.659
#204	HSF2	12	11	23	1404.894
#205	E2F7	12	11	23	622.719
#206	LASS6	12	17	29	2195.928
#207	BCL11B	12	15	27	2157.902
#208	EHF	11	15	26	703.878
#209	SOX10	11	7	18	469.69
#210	NR2F1	11	18	29	1052.512
#211	CREB1	11	8	19	453.116
#212	TWIST1	11	17	28	924.537
#213	HOXC10	11	12	23	1114.539
#214	ZSCAN29	11	9	20	1577.961
#215	GLI3	11	11	22	636.146
#216	PRDM2	11	10	21	1278.962
#217	REST	11	10	21	1073.487
#218	OVOL1	11	10	21	1696.378
#219	TAL1	11	7	18	146.122
#220	ZNF175	11	14	25	3122.949
#221	SOX12	11	13	24	1819.483
#222	MLLT10	11	16	27	856.967
#223	RELB	11	9	20	534.738
#224	MEIS3P1	11	15	26	1311.957
#225	NFAT5	11	10	21	504.25
#226	GABPB1	11	13	24	512.506
#227	MSC	11	5	16	618.74
#228	TFDP2	11	16	27	771.945
#229	EOMES	11	6	17	212.441
#230	IRX2	11	12	23	958.365
#231	MTA1	10	16	26	1395.214
#232	HOXB3	10	11	21	1868.628
#233	SMAD1	10	13	23	2495.786
#234	HMGB2	10	10	20	1811.235
#235	CTNNB1	10	17	27	2873.404
#236	STAT4	10	8	18	462.375
#237	ZNF24	10	11	21	924.669
#238	FOXQ1	10	13	23	1486.662
#239	SOX4	10	12	22	2232.89
#240	ZNF500	10	16	26	1195.991
#241	CDKN2A	10	16	26	1628.499
#242	SCMH1	10	9	19	423.451
#243	ZNF33B	10	15	25	5364.222
#244	IRF6	10	11	21	836.134
#245	NFKB1	10	15	25	2939.079
#246	KLF6	10	16	26	1242.894
#247	TAF10	10	11	21	1497.617
#248	SLC2A4RG	10	7	17	546.05
#249	PHTF1	10	14	24	2791.875
#250	HES6	10	17	27	2482.537
#251	CTBP1	10	16	26	4382.797
#252	TGIF2	10	11	21	1519.812
#253	GATAD2A	10	10	20	943.87
#254	MYT1	10	6	16	2271.24
#255	PAX6	10	12	22	730.961
#256	SPIB	10	5	15	1160.267
#257	SATB1	10	15	25	2701.776
#258	SP3	10	14	24	1628.134
#259	BTAF1	9	15	24	820.567
#260	NR4A1	9	5	14	142.225
#261	SOX11	9	18	27	952.559
#262	NR2C1	9	17	26	1294.694
#263	CEBPD	9	16	25	1854.923
#264	SOX8	9	11	20	2228.39
#265	SPEN	9	10	19	1043.914
#266	HES1	9	15	24	1687.238
#267	GATA2	9	14	23	691.915
#268	KLF7	9	11	20	1052.802
#269	NFIA	9	15	24	1112.205
#270	RERE	9	14	23	805.212
#271	JUN	9	15	24	1010.197
#272	RFX5	9	9	18	595.75
#273	TEAD3	9	17	26	562.55
#274	BHLHE41	9	10	19	508.32
#275	ZNF268	9	15	24	1049.219
#276	TRIM28	9	15	24	977.843
#277	PGR	9	10	19	503.339
#278	MEOX2	9	11	20	916.67
#279	C1orf85	9	16	25	2787.484
#280	FOXF2	9	16	25	1669.661
#281	CNOT8	8	16	24	1321.947
#282	TCF7L2	8	15	23	430.244
#283	KLF4	8	21	29	1870.979
#284	ASCL2	8	15	23	2037.265
#285	SIX4	8	13	21	566.604
#286	SNAI2	8	19	27	871.307
#287	HOXB2	8	8	16	1088.684
#288	KDM5B	8	9	17	617.878
#289	IRF4	8	10	18	317.574
#290	PURB	8	14	22	1524.368
#291	LHX2	8	6	14	465.329
#292	MYCL1	8	16	24	1577.895
#293	TCFL5	8	20	28	747.978
#294	CITED2	8	10	18	1414.183
#295	SALL2	8	18	26	1967.05
#296	TFAM	8	12	20	866.57
#297	ZNF135	8	14	22	1227.31
#298	AR	8	14	22	3747.977
#299	UHRF1	8	14	22	928.788
#300	ZKSCAN1	8	7	15	373.193
#301	TAF5	8	18	26	1608.631
#302	HOXD3	8	8	16	574.875
#303	FOXC2	8	11	19	1598.802
#304	CREBZF	8	16	24	756.953
#305	ATF5	8	12	20	638.761
#306	STAT5B	8	14	22	1597.489
#307	FBXW7	8	14	22	1053.936
#308	LASS2	8	16	24	1078.052
#309	BATF3	8	14	22	1889.761
#310	RXRA	8	16	24	552.449
#311	KLF10	8	7	15	533.327
#312	ZC3H8	8	16	24	1574.674
#313	PLAGL2	8	11	19	1617.325
#314	DRAP1	8	11	19	1440.763
#315	CREB3	8	11	19	1043.565
#316	ARNT	8	11	19	1300.901
#317	FOS	8	6	14	221.214
#318	SUPT6H	8	13	21	822.972
#319	RB1	8	15	23	1244.522
#320	NFATC3	7	12	19	593.191
#321	MXD1	7	14	21	691.754
#322	SOX6	7	12	19	1819.646
#323	TRIM25	7	15	22	810.352
#324	TEF	7	10	17	1005.961
#325	ZNF236	7	13	20	1515.876
#326	NPAS2	7	15	22	1138.457
#327	HOXA9	7	10	17	1096.767
#328	HR	7	16	23	981.345
#329	ETV5	7	20	27	1672.822
#330	TBX1	7	14	21	1491.586
#331	C11orf9	7	8	15	578.08
#332	CREB3L1	7	14	21	667.929
#333	ZNF277	7	20	27	2459.11
#334	HMBOX1	7	13	20	2151.247
#335	MNX1	7	12	19	664.317
#336	THRA	7	13	20	3564.442
#337	LCOR	7	13	20	1027.647
#338	ZNF92	7	13	20	745.97
#339	RARB	7	13	20	2343.583
#340	IRF9	7	17	24	1851.351
#341	BUD31	7	18	25	1683.011
#342	TAF1B	7	13	20	526.638
#343	GLIS2	7	11	18	1371.258
#344	NOTCH1	7	13	20	938.087
#345	HEY1	7	18	25	960.11
#346	ELF5	6	16	22	455.675
#347	SIN3A	6	16	22	1136.178
#348	TCF12	6	10	16	1168.483
#349	CLOCK	6	13	19	812.548
#350	ENO1	6	16	22	1406.76
#351	ZXDC	6	12	18	1150.567
#352	RORA	6	10	16	611.25
#353	SP1	6	11	17	1367.57
#354	ZNF140	6	19	25	2622.215
#355	BHLHE40	6	15	21	1122.783
#356	TSC22D1	6	19	25	903.685
#357	HEYL	6	17	23	955.058
#358	CIR1	6	9	15	1182.718
#359	ZSCAN18	6	14	20	866.073
#360	RUNX1	6	14	20	606.805
#361	TBX3	6	22	28	1118.784
#362	ZNF232	6	17	23	527.304
#363	ONECUT2	6	18	24	3293.353
#364	TAF4	6	12	18	1091.147
#365	TRERF1	6	15	21	1415.438
#366	IRF5	6	13	19	542.931
#367	SNAPC4	6	10	16	831.991
#368	JDP2	6	16	22	1186.586
#369	GTF2H4	6	17	23	985.803
#370	BACH1	6	15	21	501.632
#371	TRPS1	6	15	21	291.802
#372	ELF3	6	15	21	294.992
#373	FOXN2	6	8	14	336.966
#374	FOXP4	6	13	19	522.026
#375	TSC22D3	6	13	19	715.588
#376	HOXA1	6	15	21	1699.183
#377	MSL3	6	11	17	449.936
#378	ZNF33A	6	14	20	376.806
#379	CEBPA	6	19	25	1296.283
#380	BATF2	6	12	18	1153.932
#381	JUNB	6	10	16	768.825
#382	ZFPM2	6	19	25	987.848
#383	TULP4	5	13	18	750.449
#384	KDM5A	5	13	18	263.543
#385	ZNF117	5	15	20	783.172
#386	ZHX2	5	20	25	1478.053
#387	ZNF274	5	11	16	448.385
#388	MYC	5	18	23	433.265
#389	TSC22D2	5	17	22	1652.354
#390	HOXC11	5	11	16	1035.404
#391	ZNF256	5	20	25	1024.841
#392	FOXP2	5	12	17	1129.907
#393	JUND	5	18	23	1059.098
#394	PRDM1	5	10	15	722.366
#395	PBX3	5	13	18	658.513
#396	NFYA	5	14	19	1683.365
#397	ARNT2	5	19	24	528.185
#398	HHEX	5	14	19	444.352
#399	PITX1	5	12	17	961.974
#400	TP53	5	6	11	1097.678
#401	NFIB	5	20	25	392.596
#402	HIRA	5	16	21	1844.81
#403	TWIST2	5	14	19	456.397
#404	ZSCAN5A	5	15	20	558.415
#405	NFXL1	5	9	14	619.863
#406	IRF7	5	19	24	811.324
#407	CBFA2T3	5	16	21	664.197
#408	HOXB4	5	9	14	961.608
#409	STAT3	5	17	22	901.804
#410	HEY2	5	18	23	885.714
#411	PURA	5	16	21	511.162
#412	SOX13	5	16	21	419.682
#413	ZNF202	5	10	15	1505.06
#414	ZNF397	5	11	16	518.526
#415	MAFK	5	16	21	615.654
#416	HOXA10	5	18	23	1531.238
#417	GLIS3	5	12	17	326.883
#418	ETV1	5	15	20	800.106
#419	NKX3-1	5	18	23	927.85
#420	MYF6	4	4	8	119.691
#421	BCL3	4	17	21	516.447
#422	TCF3	4	20	24	375.541
#423	USF1	4	13	17	751.664
#424	ZNF83	4	18	22	1618.186
#425	ZIC2	4	7	11	802.323
#426	EGR1	4	17	21	843.327
#427	GCFC1	4	13	17	450.958
#428	MEIS1	4	13	17	546.743
#429	KLF12	4	15	19	476.949
#430	ASCL1	4	15	19	862.056
#431	TFCP2L1	4	18	22	439.198
#432	SMAD6	4	15	19	568.666
#433	VDR	4	16	20	359.01
#434	ZNF165	4	17	21	607.341
#435	SATB2	4	17	21	956.167
#436	FOXD1	4	12	16	211.085
#437	TEAD1	4	14	18	211.865
#438	WNT5A	4	18	22	2309.914
#439	ZNF85	3	18	21	405.967
#440	NR4A2	3	16	19	611.816
#441	KLF15	3	21	24	674.72
#442	HOXB6	3	9	12	716.036
#443	PPARG	3	13	16	585.706
#444	SIX1	3	24	27	3531.644
#445	FOXO6	3	13	16	329.515
#446	GATA6	3	22	25	842.269
#447	MYCN	3	18	21	1128.254
#448	ATF6	3	15	18	992.51
#449	RORC	3	15	18	2331.539
#450	DLX1	3	4	7	2237.225
#451	HOXD9	3	10	13	68.379
#452	GATAD2B	3	16	19	354.305
#453	CUX1	3	13	16	631.615
#454	PBX4	3	8	11	138.827
#455	ZRANB2	3	10	13	209.309
#456	SOX2	3	5	8	412.667
#457	MMP14	3	19	22	818.701
#458	SLC30A9	3	19	22	515.423
#459	TFEB	3	18	21	997.239
#460	MKX	3	5	8	625.017
#461	TCF7	3	15	18	171.6
#462	ARNTL	3	18	21	335.317
#463	E2F6	3	18	21	610.594
#464	ZNF93	2	13	15	548.113
#465	ZNF174	2	11	13	609.948
#466	FOXG1	2	14	16	482.504
#467	HOXD1	2	16	18	319.7
#468	MEF2A	2	15	17	1376.367
#469	MLL	2	19	21	192.03
#470	PLAG1	2	14	16	426.088
#471	NR1D2	2	21	23	382.003
#472	MSX1	2	15	17	113.166
#473	LZTS1	2	19	21	1568.983
#474	MESP1	2	16	18	1782.841
#475	NR3C2	2	20	22	581.417
#476	ATF7	2	20	22	678.546
#477	TAF6	2	16	18	376.439
#478	NFIX	2	15	17	162.983
#479	NFATC2	2	17	19	2751.577
#480	CNOT7	2	14	16	555.787
#481	TFAP2B	2	19	21	763.605
#482	SLC26A3	1	10	11	1041.896
#483	HOXD10	1	15	16	43.69
#484	NR2F2	1	21	22	1647.747
#485	CITED1	1	17	18	575.779
#486	KLF2	1	17	18	704.256
#487	WT1	1	18	19	286.279
#488	SREBF1	1	14	15	186.007
#489	TGIF1	1	17	18	221.956
#490	SIM1	1	13	14	172.104
#491	ZNF167	1	17	18	131.025
#492	ZIC3	1	6	7	64.17
#493	ST18	1	4	5	32.739
#494	RBCK1	1	14	15	292.119
#495	LEF1	0	21	21	0
#496	ZNF323	0	20	20	0
#497	DBP	0	12	12	0
#498	IRF1	0	16	16	0
#499	FOSL2	0	22	22	0
#500	HOPX	0	18	18	0