Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	ZNF148	77	6	83	985.319
#2	PHOX2B	71	3	74	618.845
#3	ASCL2	66	11	77	1832.49
#4	ZNF131	63	8	71	5218.289
#5	RELB	60	7	67	455.663
#6	NFYB	58	5	63	197.967
#7	NFXL1	58	5	63	120.624
#8	ZNF117	52	11	63	569.749
#9	USF2	51	5	56	3177.949
#10	TAF6	50	3	53	227.701
#11	C2orf3	50	5	55	271.576
#12	KLF4	50	9	59	1689.048
#13	SOX4	47	9	56	980.081
#14	YEATS4	47	6	53	702.007
#15	CIR1	45	11	56	427.518
#16	ZNF19	45	4	49	771.935
#17	VDR	44	7	51	3640.454
#18	NFIC	44	14	58	1649.866
#19	E2F6	44	5	49	135.221
#20	GCFC1	42	7	49	286.025
#21	MYC	42	11	53	651.448
#22	MSL3	40	7	47	437.091
#23	NFE2L3	40	13	53	9202.562
#24	FOSL2	40	11	51	9972.341
#25	SCML1	39	13	52	2445.759
#26	E2F2	38	12	50	1552.121
#27	ZNF140	38	9	47	1560.555
#28	MAFK	38	5	43	107.263
#29	TCF25	38	10	48	7401.092
#30	SOX9	38	13	51	924.73
#31	HSF2	36	13	49	1025.024
#32	TFCP2L1	36	13	49	15053.522
#33	PROX1	35	10	45	674.839
#34	ZNF92	34	10	44	1378.082
#35	FOXN4	34	3	37	41.955
#36	KLF6	34	8	42	401.958
#37	NFE2L1	34	9	43	393.258
#38	KLF2	33	14	47	1471.347
#39	ZNF367	33	7	40	668.843
#40	MXD1	33	9	42	3240.302
#41	CUX1	32	10	42	586.028
#42	CBFB	32	11	43	865.104
#43	ZNF268	32	7	39	238.347
#44	MEF2D	32	8	40	778.921
#45	NFKB2	32	7	39	303.738
#46	CDX2	31	9	40	1056.727
#47	MEIS1	31	8	39	8984.92
#48	NR3C2	31	12	43	4936.074
#49	TSC22D4	31	11	42	507.143
#50	BLZF1	31	15	46	1934.443
#51	ETV1	31	10	41	1319.067
#52	RARG	31	3	34	80.828
#53	ZNF281	31	9	40	942.344
#54	E2F3	31	14	45	891.529
#55	ELF4	31	12	43	617.941
#56	GABPA	30	10	40	2511.152
#57	IRF3	30	14	44	11143.615
#58	FUBP1	30	10	40	460.229
#59	HNF4A	30	16	46	1924.84
#60	RBPJ	30	8	38	4111.877
#61	TAF1B	29	12	41	2061.878
#62	JUND	29	11	40	315.29
#63	NR2F6	28	10	38	1199.617
#64	ADNP	28	9	37	1301.01
#65	FOXK2	28	16	44	3096.1
#66	TCFL5	27	12	39	1443.047
#67	HAND1	27	7	34	7574.739
#68	FOXQ1	27	17	44	6447.493
#69	OVOL1	27	10	37	1104.997
#70	ZEB1	27	2	29	77.609
#71	ZNF639	26	6	32	1233.718
#72	FOXP1	26	6	32	132.071
#73	RXRA	26	13	39	8691.878
#74	LEF1	26	17	43	1154.281
#75	CITED1	26	13	39	1688.518
#76	MYNN	26	8	34	206.653
#77	TGIF2	26	14	40	2152.873
#78	AHCTF1	26	12	38	728.038
#79	ESRRA	26	15	41	6487.511
#80	PLAGL2	25	10	35	2692.613
#81	PURA	25	12	37	1115.758
#82	TCEAL1	25	11	36	287.468
#83	FOXN2	25	13	38	599.79
#84	SPDEF	25	13	38	755.922
#85	NFAT5	25	14	39	4968.668
#86	KLF9	25	14	39	3755.686
#87	NR2C1	25	8	33	1660.952
#88	TCF4	24	6	30	779.724
#89	RB1	24	12	36	1183.26
#90	C5orf41	24	20	44	9251.586
#91	HMGA2	23	18	41	5644.348
#92	IRF6	23	13	36	1212.428
#93	ZXDC	23	11	34	632.687
#94	ZNF236	23	12	35	403.555
#95	E2F5	22	8	30	157.643
#96	CREBZF	22	14	36	1618.994
#97	SLC30A9	22	18	40	4492.745
#98	GABPB1	22	11	33	756.53
#99	ARID4A	22	10	32	5546.102
#100	MEOX1	22	8	30	357.226
#101	NOLC1	22	14	36	1070.855
#102	TEAD4	21	11	32	3404.419
#103	TAF5	21	12	33	304.797
#104	TRPS1	21	17	38	11623.039
#105	SPIB	21	14	35	5114.553
#106	FOXA3	21	13	34	2084.564
#107	HMGA1	21	17	38	1903.718
#108	ZRANB2	21	8	29	805.151
#109	NKX2-3	21	10	31	742.935
#110	TAF4	20	5	25	1361.232
#111	JUNB	20	9	29	338.884
#112	GTF2IRD1	20	14	34	3583.236
#113	NR3C1	20	11	31	1029.775
#114	UHRF1	20	8	28	872.681
#115	BCL11B	20	13	33	1590.821
#116	TARDBP	20	8	28	1499.405
#117	ZSCAN16	20	12	32	641.04
#118	ATF2	19	15	34	533.463
#119	MGA	19	20	39	1379.817
#120	CITED2	19	11	30	2547.313
#121	STAT6	19	10	29	316.783
#122	MSRB2	19	11	30	1247.804
#123	ZNF215	19	13	32	360.872
#124	UBN1	19	15	34	817.763
#125	MITF	19	9	28	2071.917
#126	HOXD1	19	18	37	1115.566
#127	TSC22D1	19	16	35	979.701
#128	FOXF1	19	4	23	67.759
#129	RUNX1T1	19	7	26	838.079
#130	STAT3	19	10	29	152.249
#131	CSRNP1	18	9	27	1148.923
#132	PPARD	18	10	28	509.626
#133	LMO4	18	15	33	2390.221
#134	MAF	18	7	25	806.466
#135	ZNF449	18	15	33	1784.969
#136	TCF21	18	6	24	637.657
#137	CREB1	18	12	30	813.16
#138	PEG3	18	8	26	2939.339
#139	GAS7	18	7	25	234.41
#140	ZXDA	18	13	31	3751.556
#141	PCGF6	18	8	26	103.236
#142	SOLH	18	17	35	895.996
#143	PTTG1	17	13	30	4464.301
#144	ETV4	17	16	33	5275.051
#145	ZNF193	17	12	29	421.911
#146	SATB2	17	16	33	3928.194
#147	TCF7L2	17	17	34	354.768
#148	ARNTL2	17	17	34	2886.959
#149	ATF6	17	17	34	1254.095
#150	ZNF445	16	13	29	557.043
#151	ZNF277	16	15	31	497.702
#152	ZFP36L2	16	15	31	1531.182
#153	E2F8	16	8	24	555.836
#154	HNF1B	16	14	30	13280.404
#155	NFATC1	16	17	33	1752.409
#156	MLX	16	18	34	3007.191
#157	TRERF1	16	12	28	2125.969
#158	RFXAP	16	13	29	345.898
#159	SLC26A3	15	29	44	4320.467
#160	E2F7	15	8	23	96.614
#161	SMAD5	15	9	24	1617.771
#162	ZFHX3	15	23	38	3277.205
#163	ZEB2	15	7	22	302.62
#164	ARID3A	15	10	25	1155.751
#165	SP3	15	13	28	242.637
#166	ETV7	15	15	30	8588.05
#167	ZNF33B	15	16	31	880.934
#168	CREB3	15	12	27	565.659
#169	RUNX1	15	12	27	1782.768
#170	MLLT10	15	16	31	1013.209
#171	ECSIT	15	15	30	1201.901
#172	AATF	15	17	32	321.696
#173	TCF19	15	7	22	1032.027
#174	YY1	14	14	28	674.917
#175	TFDP1	14	16	30	1837.016
#176	MAX	14	14	28	1822.552
#177	BCL3	14	17	31	942.403
#178	TAF4B	14	17	31	3011.207
#179	EPAS1	14	18	32	11535.947
#180	HOXA9	14	11	25	6681.225
#181	GLI3	14	4	18	45.005
#182	SREBF2	14	17	31	3484.517
#183	XBP1	14	23	37	8567.423
#184	ZKSCAN1	14	17	31	2773.269
#185	EDF1	14	10	24	355.029
#186	LASS6	14	16	30	774.739
#187	SMAD3	14	10	24	131.891
#188	SIX4	14	11	25	13726.385
#189	CTBP1	14	12	26	635.544
#190	CREBL2	14	17	31	2559.481
#191	BTAF1	14	14	28	521.255
#192	HOXA5	14	1	15	322.16
#193	TFAM	13	16	29	1094.346
#194	TGIF1	13	17	30	3788.491
#195	HOXB8	13	10	23	1529.414
#196	NR5A2	13	21	34	2633.719
#197	ELK4	13	15	28	1294.645
#198	CBFA2T2	13	12	25	1528.412
#199	SCAND1	13	14	27	363.608
#200	RCAN1	13	14	27	943.158
#201	ATF3	13	8	21	618.962
#202	ISX	13	20	33	3737.014
#203	TSHZ3	13	12	25	496.421
#204	HES6	13	18	31	1483.853
#205	ZC3H8	13	10	23	3248.044
#206	PBX1	13	15	28	823.615
#207	ZNF138	13	12	25	283.182
#208	ATF7	13	14	27	843.669
#209	TAF5L	13	10	23	1516.596
#210	TBX10	12	15	27	1917.213
#211	PRDM2	12	14	26	1089.284
#212	PA2G4	12	17	29	2064.499
#213	GRHL3	12	19	31	4690.112
#214	HES1	12	14	26	312.545
#215	MYCN	12	15	27	1168.662
#216	HMG20B	12	16	28	892.956
#217	MSX2	12	18	30	1531.796
#218	HOXC9	12	15	27	1862.828
#219	KLF7	12	16	28	2046.16
#220	KDM5A	12	16	28	2391.957
#221	SIX1	12	13	25	12026.083
#222	NCOR1	12	17	29	783.392
#223	HOXB2	12	22	34	2318.746
#224	MYBL2	12	21	33	4266.631
#225	TSHZ1	12	14	26	1426.619
#226	SMAD2	12	12	24	4155.374
#227	NR1I2	11	14	25	1439.517
#228	SMAD4	11	15	26	13528.555
#229	NR2F2	11	13	24	1772.436
#230	AEBP1	11	6	17	110.481
#231	TFEC	11	17	28	1069.207
#232	PPARG	11	23	34	3042.488
#233	KLF11	11	16	27	513.805
#234	TULP4	11	14	25	1652.295
#235	ZNF397	11	11	22	365.353
#236	HMGB1	11	16	27	2064.98
#237	FOSB	11	13	24	158.166
#238	MEIS2	11	12	23	724.118
#239	KLF5	11	14	25	263.653
#240	ZIC2	11	19	30	1855.222
#241	STAT1	11	16	27	710.343
#242	CREB3L1	11	15	26	433.74
#243	TEAD1	11	18	29	911.859
#244	GATAD2B	11	9	20	272.935
#245	NR1D2	11	21	32	936.326
#246	PBX3	11	12	23	1192.012
#247	SCML2	11	11	22	201.522
#248	EHF	11	11	22	2610.165
#249	STAT4	10	10	20	3241.075
#250	CBFA2T3	10	15	25	1639.589
#251	MEF2C	10	12	22	431.058
#252	MAFF	10	13	23	872.106
#253	FOXF2	10	10	20	1193.921
#254	TSC22D3	10	14	24	603.004
#255	KCNH8	10	19	29	2043.606
#256	FLI1	10	8	18	711.747
#257	TSHZ2	10	11	21	9930.09
#258	NFIA	10	18	28	926.379
#259	HOXD9	10	12	22	8007.314
#260	FOS	10	17	27	815.576
#261	ETS1	10	15	25	1417.4
#262	ZSCAN18	10	25	35	2102.775
#263	PGBD1	10	15	25	1049.34
#264	SMAD1	10	12	22	235.378
#265	TFE3	10	12	22	240.194
#266	PLAG1	10	23	33	1373.442
#267	ATF1	10	10	20	163.64
#268	CCRN4L	10	19	29	752.176
#269	HOXA1	9	11	20	2775.737
#270	CREM	9	12	21	388.118
#271	NR4A1	9	17	26	516.744
#272	MYT1	9	15	24	3760.674
#273	CEBPA	9	13	22	276.785
#274	ZBTB38	9	15	24	2895.477
#275	NFYA	9	14	23	402.44
#276	MECOM	9	15	24	712.217
#277	CSDA	9	23	32	1041.126
#278	NR2F1	9	13	22	1023.907
#279	AHR	9	14	23	797.681
#280	HOXA11	9	9	18	3419.23
#281	BACH1	9	13	22	612.978
#282	HDAC2	9	12	21	620.387
#283	GLIS2	9	7	16	146.097
#284	ZFPM2	9	11	20	2264.329
#285	BHLHE41	9	16	25	3409.731
#286	ZNF217	9	15	24	747.464
#287	ST18	9	12	21	1096.34
#288	NFIB	9	19	28	3589.902
#289	HOXA10	9	7	16	771.482
#290	GATAD1	9	12	21	819.737
#291	HIRA	9	11	20	805.756
#292	HOXA7	9	11	20	1819.051
#293	ZNF83	9	25	34	4319.532
#294	HOXB6	8	15	23	565.12
#295	FOXO3	8	18	26	627.558
#296	IKZF1	8	12	20	3632.989
#297	GTF2H3	8	15	23	2468.118
#298	FOXA2	8	22	30	3221.691
#299	CREB3L4	8	10	18	1261.638
#300	C11orf9	8	17	25	670.596
#301	NOTCH1	8	17	25	1849.976
#302	RUNX2	8	17	25	565.443
#303	SIM2	8	14	22	166.088
#304	ZNF202	8	16	24	424.303
#305	ZNF91	8	13	21	1971.85
#306	ZNF133	8	14	22	702.171
#307	RERE	8	9	17	227.878
#308	HCLS1	8	15	23	1823.76
#309	CREB5	8	23	31	530.674
#310	ENO1	8	19	27	1696.431
#311	WNT5A	8	16	24	749.215
#312	RCOR1	8	12	20	4874.167
#313	TFAP2A	8	19	27	2677.524
#314	TAF12	8	13	21	1190.451
#315	FOXM1	8	18	26	741.216
#316	TEF	8	12	20	225.219
#317	PHTF1	8	12	20	739.508
#318	TFDP2	8	15	23	421.076
#319	ZNF643	8	17	25	678.004
#320	IRF8	8	21	29	2099.247
#321	FOXA1	8	16	24	3715.427
#322	TFEB	8	14	22	1774.875
#323	MKX	8	16	24	774.033
#324	JUN	8	15	23	1212.54
#325	IRX5	7	17	24	2423.051
#326	HOXB5	7	13	20	946.507
#327	ZNF274	7	14	21	658.443
#328	HR	7	19	26	405.427
#329	SOX30	7	17	24	904.84
#330	NR4A2	7	16	23	2000.438
#331	SREBF1	7	17	24	986.167
#332	TBX3	7	18	25	2636.671
#333	IRF9	7	17	24	1540.567
#334	CEBPD	7	15	22	1486.679
#335	NFE2L2	7	15	22	3549.267
#336	ZNF81	7	18	25	378.243
#337	BATF2	7	14	21	887.138
#338	ZHX1	7	11	18	625.438
#339	TP53	7	23	30	6653.828
#340	MEIS3P1	7	18	25	632.403
#341	HMGB2	7	12	19	368.56
#342	HOXD11	7	13	20	2614.834
#343	ZNF189	7	17	24	550.609
#344	ZFP36L1	7	18	25	603.32
#345	HNF4G	7	19	26	2160.574
#346	HOXA3	7	10	17	891.718
#347	HOXA2	7	14	21	450.355
#348	ZGPAT	7	15	22	622.473
#349	ATOH1	7	13	20	15025.08
#350	ETV5	7	12	19	750.041
#351	ZNF165	7	15	22	1191.016
#352	CEBPB	7	12	19	729.504
#353	PITX1	7	15	22	725.574
#354	CDKN2A	7	19	26	1871.019
#355	ELF1	7	14	21	349.237
#356	HOXD13	7	15	22	700.495
#357	SOX6	6	23	29	888.023
#358	HOXB9	6	10	16	149.017
#359	RORA	6	17	23	292.56
#360	HOXD10	6	13	19	2426.988
#361	KDM5B	6	19	25	1941.11
#362	YBX1	6	21	27	648.021
#363	SPEN	6	14	20	503.386
#364	BCL6	6	18	24	1080.089
#365	TCF7L1	6	12	18	358.927
#366	NR4A3	6	12	18	923.174
#367	EBF1	6	12	18	151.545
#368	HLF	6	18	24	1850.788
#369	TRIM22	6	17	23	672.149
#370	EGR3	6	21	27	1522.244
#371	FOXP2	6	28	34	1752.708
#372	SATB1	6	16	22	610.246
#373	EGR1	6	10	16	435.931
#374	ZFP37	6	16	22	244.456
#375	DLX1	6	16	22	14687.443
#376	MLL	6	13	19	1458.319
#377	NR1H4	6	12	18	340.378
#378	FOXP4	6	11	17	638.682
#379	ONECUT2	6	21	27	871.693
#380	PPARA	6	15	21	466.456
#381	ZNF238	6	15	21	990.413
#382	PBX4	6	18	24	1171.752
#383	ZNF323	6	19	25	394.775
#384	GTF2H2	5	14	19	1362.062
#385	GLIS3	5	24	29	1050.07
#386	ZNF93	5	13	18	474.661
#387	ELK3	5	19	24	797.137
#388	HOXA13	5	11	16	1100.633
#389	SOX8	5	23	28	1801.509
#390	TRIM28	5	13	18	333.81
#391	ARNT2	5	21	26	1133.852
#392	PAX6	5	14	19	1379.317
#393	CNOT8	5	15	20	631.786
#394	PITX2	5	19	24	209.97
#395	THRB	5	23	28	617.819
#396	ZNF134	5	15	20	432.29
#397	SALL1	5	22	27	1034.467
#398	MTA1	5	17	22	590.941
#399	HOXB13	5	20	25	669.327
#400	ARX	5	17	22	703.379
#401	ZFP90	5	18	23	158.626
#402	L3MBTL4	5	23	28	1561.408
#403	IRF1	5	10	15	682.911
#404	SNAI2	5	10	15	253.994
#405	MAFB	5	15	20	372.556
#406	MEF2A	5	15	20	163.481
#407	PRRX1	5	12	17	465.308
#408	FOXD1	5	24	29	3447.653
#409	SOX1	5	13	18	1242.816
#410	VAV1	5	13	18	474.028
#411	DMRT1	5	9	14	2160.819
#412	TCF12	5	10	15	720.249
#413	FOXK1	5	16	21	125.834
#414	PAX7	5	14	19	1983.03
#415	ZHX2	5	18	23	1432.639
#416	SOX7	5	16	21	1090.939
#417	NFATC2	5	24	29	1018.022
#418	FOXC2	5	21	26	1716.858
#419	RORC	4	23	27	217.441
#420	ISL1	4	30	34	4741.23
#421	BTG2	4	19	23	1006.106
#422	HOXB3	4	13	17	398.724
#423	PCGF2	4	19	23	2826.993
#424	KLF12	4	22	26	904.463
#425	HOPX	4	9	13	156.16
#426	FOXC1	4	23	27	772.319
#427	PGR	4	7	11	56.29
#428	SP4	4	14	18	59.936
#429	TRIM25	4	18	22	394.337
#430	HOXD4	4	15	19	1393.486
#431	FBXW7	4	18	22	1169.417
#432	IRF7	4	15	19	1504.503
#433	KLF10	4	14	18	869.508
#434	ESRRG	4	18	22	667.304
#435	PRDM1	4	15	19	825.011
#436	TCF3	4	17	21	833.353
#437	CNOT7	4	19	23	193.289
#438	HOXA6	4	12	16	65.389
#439	HHEX	4	14	18	332.489
#440	ERG	4	13	17	296.213
#441	DDIT3	4	13	17	245.686
#442	FOXO1	4	19	23	1071.607
#443	HOXD8	4	15	19	574.915
#444	EN2	4	19	23	3694.325
#445	RUNX3	4	22	26	3303.571
#446	ETV6	3	15	18	156.376
#447	TRIM29	3	23	26	1130.397
#448	TEAD2	3	24	27	628.467
#449	HMBOX1	3	17	20	438.599
#450	NR1H2	3	20	23	183.931
#451	ZNF256	3	18	21	375.121
#452	IRF5	3	14	17	663.196
#453	SUPT4H1	3	21	24	410.131
#454	IRX3	3	18	21	658.787
#455	CBL	3	12	15	256.628
#456	SOX2	3	18	21	4933.624
#457	C1orf85	3	20	23	632.948
#458	ZNF207	3	15	18	484.819
#459	EGR4	3	14	17	294.343
#460	CREB3L2	3	19	22	271.38
#461	CSRNP3	3	24	27	366.773
#462	EGR2	3	18	21	580.933
#463	SMAD9	3	27	30	3240.892
#464	SCAND3	3	22	25	1006.217
#465	ZNF232	3	24	27	334.563
#466	KLF3	3	16	19	448.652
#467	NANOGNB	3	16	19	166.888
#468	PLSCR1	3	21	24	1207.901
#469	AFF4	3	9	12	66.381
#470	ZNF70	3	19	22	355.513
#471	WT1	3	25	28	1100.195
#472	MESP1	2	19	21	327.245
#473	TWIST1	2	15	17	240.724
#474	ELF3	2	18	20	432.677
#475	FOSL1	2	19	21	328.352
#476	HOXB7	2	15	17	207.909
#477	ZNF167	2	22	24	1135.157
#478	HEY1	2	17	19	81.342
#479	BHLHE40	2	18	20	188.068
#480	ZNF85	2	22	24	1004.914
#481	NKX2-1	2	9	11	285.447
#482	NR1H3	2	17	19	590.091
#483	MSX1	2	22	24	1059.099
#484	PURB	2	16	18	243.193
#485	CTNNB1	2	16	18	839.962
#486	RBCK1	2	17	19	2361.903
#487	ZIC1	2	13	15	578.881
#488	ELF5	1	20	21	194.219
#489	ZNF75D	1	11	12	24.551
#490	FOXN3	1	23	24	79.984
#491	TFAP2C	1	27	28	1456.374
#492	NFATC3	1	21	22	47.843
#493	FOXG1	1	21	22	552.274
#494	GATA2	1	17	18	55.459
#495	ETS2	1	19	20	79.813
#496	IRX2	1	18	19	1898.631
#497	MLXIPL	1	20	21	124.72
#498	DMRT2	1	21	22	330.23
#499	SMAD6	1	13	14	131.305
#500	TSC22D2	0	23	23	0