Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	ZNF281	38	6	44	427.652
#2	ZEB2	38	0	38	0
#3	EPAS1	38	6	44	907.109
#4	MAFG	35	1	36	288.541
#5	MITF	34	2	36	98.568
#6	MYBL2	33	3	36	735.823
#7	SMAD4	33	7	40	5131.859
#8	GTF2H3	33	5	38	2452.167
#9	HMGA1	32	4	36	1170.982
#10	FOXO1	32	6	38	503.717
#11	ZNF148	31	8	39	1474.523
#12	MAFB	31	5	36	204.933
#13	NFIC	31	6	37	386.425
#14	HMGB1	31	5	36	798.207
#15	SMAD2	31	5	36	2036.156
#16	YEATS4	29	8	37	1585.037
#17	NFYB	29	4	33	1368.539
#18	MAF	28	4	32	738.785
#19	HSF2	28	7	35	1541.051
#20	SNAI2	28	3	31	144
#21	ZEB1	28	3	31	94.174
#22	SOX6	27	3	30	364.168
#23	ZGPAT	27	8	35	1606.814
#24	ZNF131	27	2	29	109.135
#25	ZHX1	27	8	35	963.557
#26	GTF2IRD1	25	10	35	1982.952
#27	NR3C1	24	5	29	335.745
#28	PRDM1	24	13	37	1333.355
#29	SP1	24	4	28	3718.377
#30	MLLT10	24	8	32	1238.67
#31	FLI1	24	5	29	2299.904
#32	TCF7	23	8	31	2064.312
#33	KLF9	23	14	37	2558.187
#34	GATAD1	23	11	34	2095.143
#35	MSRB2	23	6	29	2749.3
#36	AHCTF1	23	12	35	2881.759
#37	TGIF2	22	7	29	1583.867
#38	ATF1	22	10	32	751.699
#39	TEAD4	22	5	27	2636.837
#40	ZSCAN16	22	13	35	2135.87
#41	ZNF207	22	3	25	131.223
#42	POU2F1	22	7	29	932.664
#43	FOXM1	22	7	29	1292.007
#44	IRF6	22	9	31	1358.511
#45	ZNF277	22	11	33	1129.731
#46	BCL6	21	8	29	1179.001
#47	ZNF639	21	10	31	937.19
#48	TAF6	21	8	29	724.043
#49	ETV5	21	5	26	1096.03
#50	RXRB	21	2	23	163.707
#51	MMP14	21	9	30	1128.564
#52	NFYC	21	9	30	2183.681
#53	SOX12	21	11	32	2598.234
#54	TFCP2L1	20	12	32	1618.949
#55	ZNF3	20	8	28	443.852
#56	ZNF367	20	5	25	638.268
#57	ETS1	20	10	30	1578.859
#58	SATB2	20	8	28	1113.83
#59	KLF6	20	13	33	1747.601
#60	ZNF268	20	10	30	2625.493
#61	PLAGL2	20	8	28	822.458
#62	CDX2	20	10	30	925.617
#63	JUNB	20	4	24	1115.245
#64	TRIM22	20	6	26	1193.827
#65	TRIM28	20	7	27	926.691
#66	NFXL1	19	7	26	382.189
#67	HNF1B	19	10	29	1642.334
#68	KLF16	19	12	31	1729.165
#69	GLI3	19	6	25	558.628
#70	SLC2A4RG	19	8	27	3817.104
#71	PPARA	19	12	31	5420.264
#72	ZNF37A	19	6	25	162.127
#73	ZNF500	19	3	22	2630.649
#74	ENO1	19	10	29	2099.481
#75	CBFA2T2	19	10	29	609.177
#76	TFEC	19	3	22	3151.436
#77	CNOT8	19	9	28	2681.117
#78	ESRRA	19	9	28	933.335
#79	MTA2	19	10	29	2580.156
#80	AEBP1	19	8	27	1997.422
#81	HMGB2	19	9	28	1119.925
#82	RELA	19	4	23	1002.607
#83	PRRX1	19	5	24	1970.884
#84	CREBL2	18	13	31	3991.502
#85	HCLS1	18	7	25	624.199
#86	EGR3	18	9	27	1627.999
#87	CREM	18	9	27	485.361
#88	HES1	18	12	30	1356.834
#89	PURA	18	5	23	289.74
#90	CEBPA	18	10	28	1993.586
#91	RFXAP	18	8	26	585.162
#92	NR2F6	17	9	26	1909.259
#93	KLF4	17	12	29	1713.414
#94	FOXO6	17	8	25	318.166
#95	MECOM	17	12	29	1041.16
#96	TSHZ3	17	3	20	1011.457
#97	MEIS2	17	12	29	1340.817
#98	E2F7	17	4	21	736.28
#99	CBFB	17	9	26	684.976
#100	FOXG1	17	10	27	3475.687
#101	ZNF232	17	12	29	2198.306
#102	FOXO3	17	12	29	2566.769
#103	SOX4	17	15	32	3559.391
#104	PITX1	17	17	34	2978.189
#105	ARID4A	17	7	24	1318.792
#106	NOTCH1	17	11	28	1457.672
#107	YY1	16	7	23	95.688
#108	NFATC1	16	8	24	1167.778
#109	LASS6	16	9	25	848.964
#110	GTF2H4	16	11	27	2420.946
#111	SCML1	16	13	29	3034.28
#112	STAT3	16	9	25	1442.981
#113	TFCP2	16	9	25	771.728
#114	ZNF140	16	9	25	978.363
#115	ZFPM2	16	8	24	199.176
#116	LCOR	16	16	32	824.519
#117	IRF2	16	11	27	1271.538
#118	SMAD6	16	12	28	3600.584
#119	HHEX	16	13	29	3318.672
#120	SMAD1	16	12	28	1580.723
#121	ELK3	16	11	27	1618.998
#122	TFAM	16	14	30	2037.876
#123	ZFP90	16	17	33	1840.285
#124	PTTG1	15	9	24	683.679
#125	NFKB2	15	11	26	1344.117
#126	FOXN3	15	13	28	1309.37
#127	HOXB6	15	6	21	1051.298
#128	NR1I2	15	7	22	1584.183
#129	NFE2L3	15	12	27	1629.283
#130	CREBZF	15	12	27	2503.229
#131	MEIS1	15	8	23	1700.165
#132	TAF4B	15	16	31	3083.376
#133	ELF2	15	7	22	849.639
#134	KLF3	15	10	25	696.656
#135	TWIST2	15	7	22	3690.689
#136	SCAND1	15	12	27	1430.419
#137	VDR	15	8	23	76.663
#138	RFXANK	15	10	25	1143.457
#139	NFIL3	15	8	23	280.565
#140	CITED2	14	17	31	1461.537
#141	AATF	14	8	22	1776.662
#142	FOXE1	14	4	18	980.564
#143	FOXF1	14	8	22	1355.418
#144	HOXD8	14	15	29	3521.938
#145	HSF1	14	13	27	1337.838
#146	LMO4	14	10	24	1395.928
#147	ADNP	14	8	22	513.793
#148	OVOL1	14	7	21	828.191
#149	TRPS1	14	8	22	3891.895
#150	CREB1	14	6	20	261.068
#151	HIC1	14	8	22	1741.848
#152	CUX1	14	12	26	1044.241
#153	ASCL2	14	13	27	3910.241
#154	TULP4	14	10	24	839.968
#155	PBX1	14	13	27	1441.478
#156	DMTF1	14	12	26	3994.416
#157	ZNF24	13	9	22	1284.456
#158	STAT4	13	8	21	634.43
#159	ATF6	13	12	25	1359.831
#160	EGR2	13	12	25	1203.386
#161	ZNF92	13	9	22	1127.811
#162	NR1H4	13	11	24	2076.682
#163	GTF2I	13	10	23	459.991
#164	HR	13	11	24	1074.527
#165	ZC3H8	13	8	21	905.997
#166	TARDBP	13	7	20	246.125
#167	E2F3	13	13	26	1731.903
#168	MAX	13	13	26	1676.331
#169	IRF3	13	5	18	330.097
#170	NFAT5	13	9	22	786.961
#171	NR4A1	13	10	23	994.149
#172	NR1H2	13	7	20	1169.827
#173	RXRA	13	15	28	2902.467
#174	CEBPB	13	10	23	2002.133
#175	STRN3	13	3	16	283.873
#176	TSC22D3	13	8	21	264.899
#177	RORA	13	7	20	190.656
#178	SOX7	12	19	31	5825.479
#179	CREB3	12	14	26	2010.029
#180	TFE3	12	7	19	429.47
#181	MLL	12	7	19	1594.703
#182	EBF1	12	8	20	716.836
#183	VTN	12	5	17	679.639
#184	HIF1A	12	8	20	742.727
#185	TRERF1	12	14	26	2880.147
#186	IRF1	12	12	24	2312.281
#187	CSRNP3	12	8	20	1286.994
#188	ATF5	12	18	30	1762.277
#189	TRIM29	12	18	30	4491.775
#190	ZNF238	12	16	28	4183.423
#191	TAF4	12	7	19	373.622
#192	RCAN1	12	14	26	1726.156
#193	FOSB	12	7	19	1002.848
#194	NR3C2	12	15	27	1451.855
#195	NFYA	12	14	26	1265.71
#196	EOMES	12	10	22	1271.166
#197	RBPJ	12	7	19	304.308
#198	ERG	11	12	23	1123.724
#199	CSRNP1	11	5	16	512.647
#200	MGA	11	10	21	904.351
#201	RUNX1	11	12	23	2639.44
#202	PEG3	11	14	25	3399.493
#203	HOPX	11	13	24	595.409
#204	SP3	11	6	17	679.026
#205	C1orf85	11	11	22	2283.336
#206	MYC	11	11	22	642.395
#207	TBX10	11	13	24	1559.734
#208	GLIS2	11	9	20	245.969
#209	UHRF1	11	6	17	334.938
#210	MEF2C	11	8	19	149.883
#211	NR2C1	11	12	23	803.154
#212	BACH1	11	10	21	564.97
#213	MZF1	11	6	17	714.024
#214	FOXP4	11	17	28	1068.289
#215	UBN1	11	17	28	2394.64
#216	MEOX2	11	6	17	1306.329
#217	CREB3L1	11	13	24	1260.92
#218	IRF9	11	9	20	4587.841
#219	E2F8	11	10	21	887.838
#220	FOS	11	6	17	493.879
#221	ATOH1	11	10	21	1655.299
#222	NR5A2	11	11	22	1045.927
#223	HOXD11	11	7	18	1283.77
#224	MEIS3P1	11	15	26	1156.238
#225	ARID3A	10	6	16	544.658
#226	FOXD1	10	16	26	5141.178
#227	JUN	10	13	23	2013.46
#228	KLF2	10	14	24	700.494
#229	ZSCAN18	10	14	24	2738.343
#230	ZBTB38	10	16	26	1260.196
#231	HOXA7	10	8	18	1479.87
#232	MXD1	10	15	25	1886.135
#233	IRF7	10	13	23	1293.355
#234	SOLH	10	11	21	1902.706
#235	GATA6	10	17	27	1421.198
#236	SPDEF	10	13	23	2430.888
#237	CNOT7	10	16	26	1661.665
#238	TAF5	10	9	19	798.212
#239	KDM5A	10	13	23	1195.494
#240	ZNF274	10	17	27	1763.589
#241	GAS7	10	7	17	267.465
#242	RERE	10	10	20	289.777
#243	BLZF1	10	15	25	1977.086
#244	HOXB5	10	5	15	567.75
#245	CREB3L4	10	15	25	2025.052
#246	ZNF256	10	12	22	903.283
#247	ERF	10	9	19	1803.094
#248	EDF1	10	9	19	1420.463
#249	DRAP1	10	9	19	1131.009
#250	ZNF189	10	13	23	1149.755
#251	HDAC1	10	8	18	1719.755
#252	TCF21	9	11	20	1051.509
#253	C5orf41	9	13	22	1656.796
#254	MLXIPL	9	15	24	1308.715
#255	ZNF192	9	6	15	219.989
#256	RB1	9	8	17	425.299
#257	FOXC1	9	16	25	2386.7
#258	GABPA	9	13	22	780.805
#259	HOXB7	9	10	19	949.368
#260	HOXA10	9	8	17	514.584
#261	ZNF323	9	14	23	2198.726
#262	PHF1	9	12	21	1022.073
#263	TWIST1	9	14	23	1590.118
#264	JUND	9	8	17	931.512
#265	ARNTL2	9	14	23	971.537
#266	MTA1	9	10	19	1097.248
#267	E2F5	9	16	25	1004.676
#268	SPI1	9	10	19	841.069
#269	HDAC2	9	14	23	1104.511
#270	PITX2	9	17	26	1576.478
#271	IKZF1	9	12	21	795.492
#272	SALL1	9	9	18	1427.187
#273	TAF12	9	11	20	722.971
#274	TCF4	9	12	21	799.693
#275	ZKSCAN1	9	15	24	1442.063
#276	ZFHX3	9	18	27	2103.462
#277	FOXF2	9	6	15	727.104
#278	PBX2	9	12	21	955.337
#279	EHF	9	17	26	4094.266
#280	SIX4	9	13	22	959.608
#281	ZXDC	9	10	19	1082.198
#282	NFIX	9	17	26	1406.321
#283	RUNX2	9	10	19	104.007
#284	SREBF1	9	15	24	1583.765
#285	TAF13	9	8	17	2565.657
#286	ONECUT2	9	10	19	1104.762
#287	BCL11B	9	14	23	1684.077
#288	KCNH8	8	13	21	1004.098
#289	TCF3	8	12	20	696.248
#290	TAF7	8	15	23	1114.441
#291	FOXC2	8	11	19	1519.314
#292	ZFP36L1	8	13	21	2890.37
#293	TFDP1	8	18	26	1171.662
#294	TFDP2	8	15	23	2477.981
#295	WNT5A	8	20	28	4108.174
#296	ZFP36L2	8	14	22	588.299
#297	TSC22D2	8	20	28	2453.458
#298	MLX	8	14	22	718.375
#299	ZXDA	8	10	18	743.01
#300	CTNNB1	8	12	20	1612.111
#301	HOXB8	8	12	20	497.303
#302	ARNTL	8	20	28	2527.412
#303	PA2G4	8	17	25	1408.163
#304	ZNF75D	8	16	24	733.557
#305	HOXA11	8	6	14	275.023
#306	ETV3	8	6	14	340.136
#307	AFF4	8	10	18	801.887
#308	ZNF165	8	17	25	1449.251
#309	LEF1	8	14	22	763.644
#310	ATF3	8	9	17	218.66
#311	SLC30A9	8	14	22	2434.68
#312	HMG20B	8	11	19	1879.34
#313	ETV6	8	12	20	764.967
#314	MAFF	8	16	24	1294.939
#315	FOXA3	8	14	22	1167.596
#316	SCML2	8	8	16	1034.472
#317	NKX2-3	8	8	16	598.31
#318	CREB3L2	8	14	22	791.841
#319	SLC26A3	8	25	33	3495.042
#320	REL	8	18	26	2993.728
#321	ATF7	8	13	21	945.715
#322	NFIA	8	14	22	957.01
#323	ST18	8	7	15	1273.149
#324	C2orf3	7	12	19	924.777
#325	TP63	7	6	13	476.622
#326	ELF1	7	14	21	1413.613
#327	NFATC3	7	13	20	1061.019
#328	NR4A3	7	8	15	846.264
#329	RCOR1	7	13	20	952.982
#330	FOSL2	7	17	24	945.108
#331	ZNF167	7	6	13	357.892
#332	GRHL3	7	10	17	1848.408
#333	RORC	7	13	20	1177.314
#334	AFF1	7	17	24	724.641
#335	FOXP1	7	12	19	634.206
#336	NPAS2	7	13	20	945.249
#337	CSDA	7	9	16	414.308
#338	SOX8	7	8	15	1049.006
#339	ZFP42	7	9	16	660.085
#340	SATB1	7	14	21	740.888
#341	ZNF41	7	14	21	1591.172
#342	PBX3	7	13	20	672.882
#343	SMAD9	7	22	29	3185.119
#344	HOXB2	7	14	21	1889.976
#345	BUD31	7	16	23	483.697
#346	BHLHE41	7	15	22	1545.819
#347	MAFK	7	12	19	547.249
#348	ETV1	7	14	21	282.119
#349	GLIS3	7	9	16	1097.635
#350	FOXD2	7	13	20	1277.568
#351	ISX	7	13	20	565.985
#352	ATF2	7	10	17	705.205
#353	ZNF217	7	12	19	978.6
#354	NFIB	7	12	19	227.653
#355	TCF25	7	11	18	950.839
#356	HOXD1	6	10	16	1077.203
#357	STAT2	6	9	15	513.168
#358	HOXD10	6	12	18	709.502
#359	JDP2	6	12	18	735.733
#360	ZNF45	6	10	16	1908.987
#361	TFEB	6	14	20	687.297
#362	FBXW7	6	10	16	600.044
#363	BATF2	6	9	15	334.766
#364	FOXA2	6	12	18	1293.513
#365	HOXA3	6	11	17	1075.819
#366	NFATC2	6	14	20	747.817
#367	CREB5	6	12	18	1073.434
#368	RUNX1T1	6	8	14	142.592
#369	KLF12	6	13	19	538.8
#370	HOXB3	6	11	17	1231.253
#371	FOXR2	6	5	11	1240.338
#372	TEAD1	6	12	18	978.027
#373	IRX5	6	10	16	1255.002
#374	PAX6	6	7	13	596.085
#375	HOXA13	6	11	17	1630.009
#376	MYCL1	6	17	23	888.701
#377	CDKN2A	6	15	21	1214.737
#378	HOXA9	6	11	17	966.876
#379	RBCK1	6	17	23	761.804
#380	EGR1	6	8	14	379.157
#381	TCFL5	6	13	19	514.489
#382	ZNF93	6	12	18	649.786
#383	CBL	6	15	21	1389.771
#384	KLF7	6	16	22	2187.591
#385	TCF7L2	6	14	20	487.876
#386	ETV4	6	15	21	768.388
#387	PROX1	5	16	21	609.108
#388	TCF12	5	15	20	663.719
#389	ZNF83	5	12	17	865.828
#390	HMBOX1	5	14	19	753.754
#391	PGBD1	5	10	15	525.452
#392	MEF2A	5	14	19	505.444
#393	ELF3	5	15	20	735.293
#394	ZNF397	5	11	16	373.896
#395	SOX9	5	15	20	1029.618
#396	HOXB9	5	14	19	1190.892
#397	SUPT6H	5	9	14	438.026
#398	GRHL2	5	15	20	1105.784
#399	TFAP2A	5	14	19	1420.555
#400	GATA5	5	8	13	609.653
#401	PURB	5	11	16	1252.152
#402	GTF2H2	5	16	21	718.389
#403	NFE2L2	5	14	19	1138.157
#404	MBD1	5	9	14	559.189
#405	NR1D2	5	13	18	1141.713
#406	C11orf9	5	13	18	544.535
#407	SMAD3	5	11	16	485.214
#408	XBP1	5	19	24	1105.994
#409	ASCL1	5	7	12	552.958
#410	SOX2	5	13	18	1047.953
#411	HES6	5	12	17	771.037
#412	NR2F1	5	18	23	735.833
#413	AHR	5	15	20	605.953
#414	PLAG1	5	15	20	1422.942
#415	THRB	4	18	22	406.138
#416	BTG2	4	10	14	249.69
#417	HIRA	4	14	18	843.568
#418	ESRRG	4	11	15	297.783
#419	BHLHE40	4	18	22	318.743
#420	SUPT4H1	4	16	20	1594.693
#421	TGIF1	4	16	20	674.812
#422	FOSL1	4	13	17	627.697
#423	ZNF117	4	18	22	1194.519
#424	ZNF91	4	11	15	894.122
#425	PPARG	4	16	20	1090.3
#426	SOX1	4	10	14	650.925
#427	NOLC1	4	15	19	1053.919
#428	SPEN	4	12	16	982.71
#429	KLF11	4	17	21	952.708
#430	HOXA2	4	9	13	911.661
#431	TEAD2	4	11	15	661.199
#432	HNF4G	4	20	24	1320.798
#433	MEOX1	4	13	17	2685.552
#434	FOXL1	4	10	14	561.3
#435	PHTF1	4	17	21	613.444
#436	SOX13	4	17	21	1175.205
#437	ZRANB2	4	13	17	370.259
#438	STAT1	4	13	17	380.143
#439	CLOCK	4	12	16	237.222
#440	NR4A2	4	14	18	870.73
#441	CEBPD	4	14	18	523.06
#442	ZNF33B	3	12	15	214.777
#443	ELF5	3	16	19	772.552
#444	PCGF2	3	16	19	1101.409
#445	ARNT2	3	10	13	449.398
#446	SOX18	3	10	13	232.519
#447	GATA4	3	8	11	1966.478
#448	ELF4	3	14	17	477.231
#449	ISL1	3	17	20	497.762
#450	HOXA5	3	12	15	793.741
#451	IRX3	3	10	13	1179.476
#452	HMGA2	3	13	16	955.164
#453	CTBP1	3	18	21	751.748
#454	NR2F2	3	12	15	233.475
#455	HNF4A	3	11	14	412.8
#456	ETS2	3	19	22	780.626
#457	ETV7	3	9	12	285.574
#458	WT1	3	20	23	2020.358
#459	HOXB13	3	21	24	1121.519
#460	SMAD5	3	18	21	309.366
#461	HIF3A	3	10	13	248.449
#462	KDM5B	3	12	15	442.382
#463	IRF8	3	16	19	293.596
#464	TSC22D1	3	15	18	519.886
#465	ZIC1	3	9	12	678.369
#466	DMRT2	3	12	15	189.362
#467	EN2	3	16	19	1325.118
#468	TP53	3	18	21	1621.643
#469	RARA	3	19	22	567.62
#470	RFX5	3	14	17	685.422
#471	KLF5	3	21	24	1406.489
#472	FOXP2	2	18	20	157.525
#473	MSX2	2	18	20	2039.386
#474	MYCN	2	12	14	115.292
#475	ZIC2	2	21	23	775.328
#476	MSX1	2	16	18	136.91
#477	EGR4	2	14	16	303.133
#478	KLF10	2	12	14	1074.608
#479	ECSIT	2	12	14	641.937
#480	TSHZ1	2	14	16	340.536
#481	IRX2	2	16	18	2112.97
#482	MESP1	2	13	15	179.572
#483	BRD8	2	11	13	257.526
#484	TBX3	2	12	14	153.355
#485	SIX3	2	7	9	275.573
#486	PLSCR1	2	8	10	548.596
#487	FOXK1	2	11	13	340.239
#488	ARNT	2	15	17	266.962
#489	NR1H3	2	10	12	438.616
#490	RUNX3	2	16	18	246.206
#491	ZNF643	2	15	17	373.086
#492	HOXD13	2	10	12	110.083
#493	SIM2	1	15	16	68.909
#494	FUBP1	1	16	17	85.422
#495	TFAP2C	1	15	16	379.842
#496	NKX2-1	1	6	7	282.449
#497	FOXQ1	0	17	17	0
#498	SCAND3	0	12	12	0
#499	FOXA1	0	22	22	0
#500	BCL3	0	18	18	0