Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	ARID3A	48	4	52	1761.435
#2	NOTCH1	47	8	55	963.793
#3	HDAC2	45	6	51	1175.735
#4	MLXIPL	43	3	46	110.532
#5	KLF9	43	5	48	319.177
#6	HLF	39	8	47	689.227
#7	LASS5	38	10	48	5556.354
#8	KLF15	38	1	39	161.327
#9	SOX4	37	6	43	627.657
#10	POU2F1	37	3	40	170.777
#11	FOXM1	36	5	41	403.356
#12	NR1I3	35	6	41	304.77
#13	SALL2	35	12	47	1249.516
#14	TEAD2	34	5	39	1040.404
#15	SOX9	34	8	42	942.167
#16	SCMH1	34	10	44	815.786
#17	GAS7	34	4	38	1037.504
#18	FOXA3	33	8	41	4412.424
#19	FOXF2	33	3	36	1144.356
#20	MTA3	33	10	43	1095.618
#21	MLL	32	6	38	319.133
#22	ELF4	32	8	40	1183.493
#23	NFIA	32	6	38	384.87
#24	TGIF2	32	10	42	670.555
#25	AR	31	9	40	1158.881
#26	HNF1B	31	7	38	1457.234
#27	NR5A2	31	11	42	1831.237
#28	ENO1	31	7	38	1403.273
#29	TBX3	31	6	37	1455.991
#30	E2F3	30	12	42	2267.51
#31	ZSCAN2	30	9	39	3102.204
#32	SP3	30	10	40	1973.409
#33	RCAN1	30	10	40	713.105
#34	PLAGL2	29	6	35	1148.382
#35	PRRX1	29	7	36	1792.963
#36	E2F2	28	4	32	223.97
#37	E2F7	28	2	30	573.879
#38	E2F1	28	4	32	131.883
#39	KDM5B	28	7	35	517.269
#40	SIX5	28	11	39	1686.01
#41	TGIF1	27	7	34	2282.163
#42	LCOR	27	10	37	926.76
#43	FOXJ1	27	17	44	4488.576
#44	CSRNP2	27	5	32	1407.22
#45	HOXC4	27	7	34	1012.16
#46	HCFC1	26	7	33	636.938
#47	ETS2	26	8	34	397.038
#48	LASS2	26	11	37	1030.403
#49	PBX2	26	5	31	251.059
#50	TEAD4	26	16	42	1705.285
#51	VTN	26	13	39	2952.233
#52	CREB1	26	8	34	679.624
#53	SREBF2	25	4	29	315.64
#54	MTA2	25	15	40	1587.468
#55	SALL1	25	9	34	889.414
#56	HOXD1	25	13	38	2147.5
#57	KLF12	25	12	37	2427.308
#58	ETV6	25	11	36	458.804
#59	ZNF193	25	9	34	2706.264
#60	NFIC	25	10	35	965.561
#61	PCGF2	25	18	43	2159.657
#62	ADNP	25	7	32	527.968
#63	RAX2	24	4	28	191.242
#64	RORC	24	15	39	1974.222
#65	HCLS1	24	3	27	193.326
#66	ETV5	24	8	32	729.143
#67	ZNF444	24	6	30	1162.334
#68	ZSCAN16	24	10	34	523.246
#69	ATF4	24	14	38	991.589
#70	TCF3	24	8	32	835.957
#71	NFIB	24	10	34	526.472
#72	SOX13	24	13	37	1787.358
#73	CREBBP	23	9	32	1607.325
#74	TSC22D4	23	13	36	2746.739
#75	SMAD3	23	10	33	2940.51
#76	TAF4	23	8	31	490.569
#77	RUNX1	23	14	37	1021.33
#78	RORA	23	13	36	435.259
#79	NFE2L3	23	16	39	2178.179
#80	HDAC1	23	8	31	359.583
#81	TCF19	23	0	23	0
#82	TCF4	23	7	30	1294.447
#83	NR1H4	22	13	35	1343.712
#84	CSDA	22	17	39	987.484
#85	POU2F2	22	4	26	2424.29
#86	FOXS1	22	4	26	556.136
#87	CBFB	22	9	31	595.684
#88	HHEX	22	9	31	1434.773
#89	ZKSCAN1	21	8	29	518.152
#90	CEBPA	21	18	39	2205.487
#91	AHR	21	2	23	392.593
#92	RUNX3	21	6	27	743.848
#93	TRIM28	21	9	30	789.199
#94	TSHZ3	21	6	27	520.169
#95	RXRA	21	8	29	1404.517
#96	NR1H3	21	17	38	2629.957
#97	REXO4	21	20	41	1401.367
#98	PURB	21	8	29	543.311
#99	PTTG1	20	6	26	162.097
#100	C11orf9	20	9	29	663.34
#101	FOXD2	20	9	29	1488.788
#102	TEAD3	20	10	30	818.612
#103	NR1I2	20	11	31	629.087
#104	HNF1A	20	12	32	1366.002
#105	FOXO1	20	18	38	3962.323
#106	ZNF69	20	22	42	3595.293
#107	ZKSCAN3	20	7	27	533.909
#108	ONECUT2	20	23	43	2231.968
#109	FOXA2	19	18	37	5971.738
#110	HNF4G	19	16	35	1178.907
#111	AATF	19	7	26	344.185
#112	GATAD2A	19	15	34	3013.221
#113	HNRNPK	19	8	27	1146.885
#114	AEBP1	19	5	24	200.957
#115	HOXC9	19	7	26	924.872
#116	ZSCAN21	19	9	28	678.028
#117	E2F5	19	16	35	2638.336
#118	ZEB2	19	4	23	312.116
#119	RBPJ	19	16	35	1521.572
#120	PRDM1	19	4	23	220.943
#121	ZNF133	19	15	34	745.925
#122	ZHX2	19	10	29	1862.951
#123	SMAD5	18	22	40	1977.818
#124	MECOM	18	18	36	1613.917
#125	PROX1	18	15	33	3081.763
#126	ZNF3	18	11	29	1397.966
#127	TSC22D1	18	11	29	918.976
#128	NME2	18	12	30	1277.158
#129	RERE	18	16	34	2464.869
#130	CUX2	18	11	29	279.727
#131	TP53	18	11	29	4044.767
#132	HOXC6	18	3	21	1004.844
#133	HIF1A	18	14	32	1827.135
#134	SUPT6H	18	14	32	1630.571
#135	CTBP1	18	13	31	1425.155
#136	ZBTB17	18	9	27	1037.426
#137	FOXD4L5	17	12	29	1555.735
#138	RELA	17	11	28	1287.081
#139	FOXD1	17	5	22	2527.23
#140	NPAS2	17	10	27	1388.858
#141	PBX3	17	17	34	2275.521
#142	E2F6	17	15	32	1611.172
#143	CEBPB	17	14	31	1724.044
#144	MTF1	17	9	26	456.768
#145	RARB	17	14	31	2746.242
#146	C5orf41	17	10	27	455.533
#147	CSRNP1	17	10	27	2083.53
#148	SCML2	17	14	31	1460.031
#149	IRX5	16	10	26	1521.622
#150	ZFP42	16	7	23	2847.647
#151	NFIX	16	9	25	391.834
#152	TBX2	16	13	29	2509.406
#153	C1orf85	16	15	31	959.013
#154	NR3C2	16	15	31	928.279
#155	ESRRG	16	11	27	911.728
#156	CBFA2T2	16	15	31	904.804
#157	KLF5	16	17	33	3772.812
#158	PLAG1	16	8	24	840.029
#159	KLF11	16	13	29	1231.704
#160	TWIST1	16	4	20	459.996
#161	FOXO4	16	13	29	2122.221
#162	ZNF207	16	10	26	445.691
#163	SP1	16	12	28	1106.814
#164	MZF1	16	10	26	898.829
#165	LZTS1	16	8	24	747.915
#166	ZNF189	16	14	30	1541.731
#167	TCEAL1	16	9	25	780.251
#168	HEYL	15	6	21	492.249
#169	UHRF1	15	12	27	549.848
#170	BCL11B	15	8	23	1171.623
#171	HOXA9	15	13	28	2833.123
#172	E2F8	15	5	20	3554.428
#173	ZNF134	15	12	27	340.743
#174	ZKSCAN4	15	4	19	457.583
#175	FLI1	15	8	23	860.328
#176	RFXANK	15	6	21	1838.142
#177	LZTR1	15	16	31	789.906
#178	ZNF238	15	13	28	3033.978
#179	GLIS3	15	6	21	120.704
#180	ZNF45	15	12	27	2335.751
#181	SPI1	15	7	22	442.366
#182	GATAD2B	15	11	26	1928.171
#183	ETS1	15	4	19	63.706
#184	TAF5	15	11	26	534.649
#185	ARID4A	15	16	31	2241.015
#186	FOXC1	14	14	28	1866.377
#187	ZFHX4	14	16	30	2328.446
#188	ZNF148	14	9	23	888.255
#189	HOXD11	14	8	22	2849.909
#190	TRIM22	14	10	24	1168.616
#191	PITX1	14	19	33	4039.805
#192	YEATS4	14	14	28	1581.953
#193	OTX1	14	15	29	1769.259
#194	ZNF256	14	12	26	525.041
#195	SRF	14	10	24	1449.713
#196	TCF12	14	16	30	728.063
#197	USF2	14	13	27	1467.853
#198	PHF5A	14	10	24	585.07
#199	ESRRA	14	20	34	2545.986
#200	FOXJ3	14	9	23	932.714
#201	MTA1	14	16	30	2083.038
#202	MLLT10	14	17	31	1486.363
#203	FOXA1	14	15	29	895.796
#204	NR2C1	14	15	29	2834.166
#205	GTF2H4	13	12	25	1055.07
#206	ELF3	13	12	25	245.771
#207	PPARG	13	20	33	3591.43
#208	MEIS2	13	19	32	1536.707
#209	EOMES	13	8	21	672.626
#210	PLSCR1	13	14	27	1244.42
#211	ASCL2	13	13	26	4201.851
#212	ZNF277	13	18	31	1407.641
#213	ZFPM1	13	15	28	2656.721
#214	FOXO3	13	11	24	886.892
#215	ZNF281	13	8	21	625.6
#216	STAT5A	13	12	25	753.331
#217	CREB3L2	13	14	27	633.292
#218	ELF1	13	21	34	2868.865
#219	NKX3-1	13	20	33	1053.872
#220	ZNF438	13	14	27	3109.894
#221	TAF4B	13	14	27	1721.766
#222	TAF10	13	19	32	1743.371
#223	TAF13	13	10	23	1055.586
#224	GABPA	13	12	25	980.636
#225	CREBL2	13	12	25	266.366
#226	HOXB13	13	4	17	992.041
#227	NFYA	12	13	25	293.107
#228	ONECUT1	12	10	22	933.215
#229	RXRG	12	11	23	992.304
#230	PHF1	12	11	23	918.429
#231	KLF2	12	12	24	637.334
#232	MYC	12	17	29	1648.307
#233	HOXB7	12	10	22	701.732
#234	EGR1	12	11	23	732.047
#235	ESR1	12	16	28	592.92
#236	TCF7L1	12	19	31	1565.487
#237	MNT	12	23	35	1451.862
#238	USF1	12	12	24	856.504
#239	NR1H2	12	17	29	1677.376
#240	STAT4	12	16	28	3767.903
#241	BTAF1	12	8	20	861.094
#242	NFE2L1	12	15	27	1087.493
#243	TCF25	12	16	28	1741.579
#244	EPAS1	12	12	24	619.941
#245	PRRX2	12	15	27	2175.441
#246	SP140	11	5	16	620.59
#247	HOPX	11	13	24	592.477
#248	POU5F1	11	17	28	1608.434
#249	MSRB2	11	13	24	1332.696
#250	E4F1	11	14	25	861.833
#251	HMGB2	11	8	19	245.113
#252	TWIST2	11	6	17	1088.364
#253	GABPB1	11	14	25	915.258
#254	ARNT	11	9	20	1421.864
#255	EDF1	11	13	24	1569.194
#256	NOBOX	11	10	21	921.405
#257	NFYB	11	17	28	1659.031
#258	CDKN2A	11	16	27	1415.658
#259	CREB3L3	11	17	28	952.561
#260	ETV4	11	18	29	880.706
#261	LASS6	10	21	31	2396.163
#262	FOXJ2	10	12	22	1444.284
#263	NFKB2	10	12	22	1454
#264	FOS	10	12	22	473.256
#265	HOXC8	10	7	17	1123.897
#266	STAT6	10	17	27	2058.479
#267	ZNF175	10	18	28	1067.512
#268	MEF2C	10	10	20	207.853
#269	PHTF1	10	18	28	3951.844
#270	GRHL2	10	12	22	1339.747
#271	HSF2	10	6	16	660.922
#272	LEF1	10	12	22	2130.69
#273	BHLHE41	10	15	25	659.907
#274	THRA	10	9	19	318.957
#275	PURA	10	14	24	1136.049
#276	SP4	10	16	26	876.86
#277	SOX12	10	16	26	615.638
#278	RELB	10	8	18	932.136
#279	TCF7L2	10	12	22	1167.188
#280	ERF	10	9	19	561.383
#281	KLF6	10	15	25	810.617
#282	ZFP36L1	10	16	26	839.836
#283	SIX4	9	21	30	1418.37
#284	CNOT7	9	19	28	1176.879
#285	STAT3	9	16	25	1936.389
#286	ARNT2	9	20	29	802.904
#287	HSF1	9	16	25	1573.063
#288	LMO4	9	24	33	1118.211
#289	ZNF33B	9	14	23	1076.722
#290	RB1	9	13	22	1140.985
#291	PPARD	9	12	21	534.834
#292	PGBD1	9	15	24	978.09
#293	ZSCAN18	9	12	21	864.505
#294	GLI3	9	9	18	712.279
#295	STRN3	9	14	23	940.135
#296	MYCL1	9	14	23	610.65
#297	PFDN1	9	13	22	583.646
#298	RARA	9	15	24	1593.565
#299	NFE2	9	14	23	1076.506
#300	IRF6	9	18	27	659.831
#301	DMTF1	9	15	24	411.053
#302	ELF2	9	16	25	821.671
#303	ISL1	9	8	17	1160.468
#304	NFYC	9	15	24	673.688
#305	DBP	8	19	27	2294.74
#306	MSL3	8	10	18	978.676
#307	ZNF219	8	17	25	670.664
#308	GATA5	8	15	23	880.118
#309	SMAD4	8	11	19	1082.681
#310	NR3C1	8	12	20	372.907
#311	MAFG	8	15	23	950.621
#312	NFX1	8	15	23	643.416
#313	EGR2	8	13	21	920.638
#314	ZHX1	8	20	28	918.906
#315	EBF1	8	13	21	319.376
#316	TFDP1	8	21	29	3011.893
#317	MYCN	8	15	23	1607.268
#318	NFE2L2	8	20	28	2354.678
#319	IRF8	8	11	19	442.009
#320	TFCP2	8	16	24	1729.48
#321	MYPOP	8	14	22	1277.777
#322	ECSIT	8	17	25	615.397
#323	MEOX1	8	9	17	192.502
#324	NCOR1	8	15	23	849.108
#325	ATF3	8	14	22	1170.201
#326	BCL6	8	18	26	2574.805
#327	MEIS1	8	15	23	1009.362
#328	SLC30A9	8	13	21	1188.331
#329	TAF1B	8	19	27	1805.943
#330	STAT1	8	16	24	823.062
#331	TSHZ2	8	20	28	962.744
#332	YY1	8	13	21	540.207
#333	TAF12	8	17	25	1539.948
#334	STAT5B	8	19	27	1793.824
#335	TADA3	8	13	21	486.182
#336	HEY2	8	12	20	898.323
#337	GTF2H3	8	16	24	1111.332
#338	ZNF213	8	16	24	802.306
#339	SPIB	8	12	20	1299.786
#340	STAT2	7	15	22	1593.473
#341	ZBTB48	7	14	21	526.572
#342	NR2F6	7	16	23	628.241
#343	ZFP90	7	22	29	2347.459
#344	BHLHE40	7	17	24	778.69
#345	ZHX3	7	13	20	956.056
#346	UBN1	7	13	20	447.674
#347	PPARA	7	14	21	819.731
#348	SUPT4H1	7	14	21	696.312
#349	LHX8	7	7	14	384.819
#350	PA2G4	7	10	17	317.045
#351	BLZF1	7	13	20	640.556
#352	SNAI2	7	19	26	802.129
#353	HNRNPAB	7	25	32	2698.946
#354	TBX15	7	23	30	812.93
#355	HNF4A	7	15	22	922.386
#356	HOXB9	7	6	13	401.811
#357	GTF2IRD1	7	18	25	625.011
#358	BATF	7	15	22	852.767
#359	TBP	7	12	19	983.642
#360	CITED2	7	21	28	2896.229
#361	SPEN	7	20	27	566.242
#362	RFX5	7	20	27	1807.885
#363	ZNF187	7	15	22	4343.272
#364	TRERF1	7	12	19	1081.03
#365	TRPS1	7	12	19	832.668
#366	HOXB8	7	8	15	1249.618
#367	HOXA10	7	18	25	1515.337
#368	ZNF174	7	23	30	1104.628
#369	NR4A2	7	13	20	423.785
#370	ZNF135	6	14	20	536.586
#371	FOXN4	6	19	25	1120.643
#372	KLF4	6	16	22	1742.612
#373	HOXB5	6	16	22	399.624
#374	HOMEZ	6	18	24	566.736
#375	POU3F2	6	13	19	2124.524
#376	POU4F1	6	11	17	584.313
#377	MSC	6	16	22	995.816
#378	FOXN2	6	17	23	752.984
#379	SREBF1	6	18	24	556.521
#380	MAF	6	20	26	902.253
#381	TSC22D3	6	25	31	831.782
#382	SOX8	6	10	16	398.506
#383	ZNF217	6	12	18	715.697
#384	TEF	6	18	24	639.704
#385	TSHZ1	6	14	20	1168.022
#386	MAFB	6	14	20	511.452
#387	PBX1	6	14	20	987.099
#388	TAF5L	6	16	22	1104.93
#389	MESP1	6	16	22	526.064
#390	DRAP1	6	22	28	1262.843
#391	ZNF83	6	24	30	2450.952
#392	RXRB	6	16	22	593.557
#393	NR2F2	6	18	24	567.752
#394	HOXD8	6	11	17	530.514
#395	ZFP37	6	7	13	341.625
#396	MNX1	6	16	22	790.6
#397	HES6	6	23	29	1779.974
#398	NFIL3	6	14	20	293.699
#399	SATB2	6	17	23	1460.12
#400	AHCTF1	6	18	24	974.676
#401	MSX1	6	13	19	1226.042
#402	AFF4	5	11	16	576.158
#403	ZNF35	5	16	21	487.661
#404	ALX3	5	11	16	463.024
#405	BTG2	5	18	23	925.399
#406	SOX11	5	9	14	373.403
#407	PCGF6	5	16	21	1154.92
#408	SNAPC4	5	14	19	399.31
#409	TULP4	5	12	17	698.335
#410	MKX	5	13	18	710.788
#411	ZNF165	5	17	22	398.027
#412	SOX18	5	12	17	189.578
#413	NFXL1	5	13	18	586.869
#414	CEBPD	5	17	22	758.848
#415	NKX3-2	5	22	27	497.163
#416	CCRN4L	5	18	23	536.509
#417	ZRANB2	5	14	19	938.159
#418	KLF10	5	17	22	520.955
#419	JUND	5	19	24	550.172
#420	ZNF263	5	11	16	853.052
#421	NR1D2	5	17	22	430.628
#422	IRF9	5	12	17	571.524
#423	ZIC2	5	26	31	589.472
#424	MXD1	5	19	24	584.636
#425	ZNF91	5	12	17	743.737
#426	BCL3	5	21	26	2458.817
#427	TCFL5	5	17	22	1185.875
#428	MLX	5	14	19	392.794
#429	ELK1	5	17	22	357.837
#430	PEG3	5	14	19	296.338
#431	ZFHX3	5	18	23	1972.384
#432	HEY1	5	15	20	413.128
#433	IRF7	5	17	22	1011.377
#434	CTNNB1	5	24	29	798.434
#435	XBP1	4	20	24	507.465
#436	WNT5A	4	17	21	1055.384
#437	NR2F1	4	25	29	471.647
#438	CREB5	4	16	20	515.763
#439	ZNF274	4	18	22	905.058
#440	IKZF1	4	13	17	497.062
#441	JUN	4	13	17	525.879
#442	RBCK1	4	20	24	398.742
#443	RHOXF2	4	17	21	720.018
#444	E2F4	4	15	19	711.774
#445	NFKB1	4	16	20	427.953
#446	HOXB6	4	11	15	537.995
#447	SCML1	4	16	20	631.721
#448	TSC22D2	4	18	22	1515.87
#449	MEOX2	4	20	24	1197.709
#450	ZNF446	4	13	17	168.37
#451	DLX1	4	3	7	22.811
#452	FOSB	4	11	15	149.366
#453	TFAP2C	4	8	12	267.116
#454	ZC3H8	4	11	15	294.4
#455	IRF1	4	16	20	359.079
#456	ALX1	4	9	13	153.277
#457	RNF4	4	24	28	507.113
#458	FBXW7	3	18	21	379.79
#459	DDIT3	3	19	22	696.561
#460	BUD31	3	18	21	367.214
#461	IRF3	3	16	19	260.898
#462	ASCL1	3	21	24	516.494
#463	ATF6	3	20	23	255.743
#464	HES1	3	21	24	374.165
#465	ATF5	3	27	30	576.485
#466	HOXA5	3	23	26	811.23
#467	ZXDC	3	20	23	415.428
#468	RUNX2	3	6	9	424.632
#469	FOXP1	3	17	20	523.549
#470	CREM	3	22	25	576.795
#471	NR0B1	3	14	17	346.654
#472	LHX2	3	18	21	1178.655
#473	CLOCK	3	22	25	734.514
#474	TFAP2A	3	21	24	1928.044
#475	SIN3A	3	14	17	176.98
#476	SLC26A3	2	21	23	477.722
#477	ZNF18	2	14	16	300.222
#478	BATF2	2	16	18	541.935
#479	MEF2D	2	16	18	140.133
#480	HOXA13	2	18	20	392.356
#481	LHX4	2	16	18	1438.373
#482	SOX6	2	17	19	603.129
#483	SLC2A4RG	2	20	22	249.212
#484	SMAD6	2	20	22	115.766
#485	EHF	2	16	18	204.656
#486	ZNF323	2	21	23	398.671
#487	UBP1	2	17	19	473.598
#488	SCAND1	2	20	22	450.137
#489	IRX3	2	28	30	875.402
#490	LHX3	2	10	12	137.795
#491	NPAS1	2	17	19	351.427
#492	HES5	2	18	20	430.571
#493	TAF7	1	20	21	50.653
#494	TFAM	1	20	21	114.343
#495	LBX2	1	18	19	347.309
#496	ISX	1	27	28	611.497
#497	ANKRD30A	1	8	9	116.749
#498	FOXQ1	1	23	24	293.915
#499	EMX1	0	13	13	0
#500	ARNTL	0	13	13	0