Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	SMAD9	46	6	52	3659.598
#2	NFAT5	38	0	38	0
#3	PRRX1	33	10	43	3725.406
#4	NFIX	32	2	34	165.34
#5	IKZF1	31	3	34	433.328
#6	AEBP1	30	4	34	361.597
#7	FLI1	29	6	35	840.749
#8	CREBL2	29	7	36	1288.748
#9	EBF1	28	5	33	1004.333
#10	PBX4	28	7	35	2392.984
#11	PRDM2	28	4	32	400.164
#12	FOXJ3	27	3	30	1255.449
#13	TAF12	25	5	30	1515.039
#14	VAV1	25	0	25	0
#15	IRF8	25	5	30	2449.324
#16	MTF1	24	2	26	332.135
#17	SPEN	24	5	29	323.915
#18	ARNTL2	24	7	31	1827.798
#19	UBN1	24	4	28	208.685
#20	NANOGNB	24	1	25	6.297
#21	SOX11	23	8	31	938.026
#22	HCLS1	23	6	29	1951.826
#23	HDAC1	23	3	26	467.439
#24	RUNX2	23	15	38	2091.59
#25	ATF1	23	4	27	2999.43
#26	ZFHX3	23	11	34	2036.102
#27	SMAD2	23	9	32	4669.079
#28	AR	23	11	34	1669.203
#29	IRF7	22	4	26	531.184
#30	LASS2	22	7	29	544.621
#31	GABPA	22	0	22	0
#32	ZSCAN18	22	15	37	6647.257
#33	RUNX1	21	8	29	1105.688
#34	HOXC4	21	3	24	214.045
#35	ELF1	21	6	27	1038.2
#36	NOLC1	21	7	28	1758.298
#37	CREB1	20	3	23	409.706
#38	TWIST1	20	10	30	2564.404
#39	TP63	20	9	29	1760.527
#40	THRA	20	6	26	1925.905
#41	SNAPC5	20	9	29	2689.536
#42	THRB	19	13	32	1420.57
#43	MAFF	19	6	25	1943.484
#44	TFEC	19	4	23	2486.938
#45	MAX	19	3	22	261.493
#46	NFATC2	19	7	26	1574.914
#47	SOX7	18	6	24	1107.391
#48	LMO4	18	10	28	1733.101
#49	KDM5B	18	6	24	662.181
#50	KLF5	18	9	27	1716.101
#51	KLF3	18	10	28	1875.144
#52	TCF25	18	3	21	932.703
#53	CEBPB	18	7	25	700.106
#54	SMAD5	18	4	22	193.435
#55	HOXC5	18	8	26	1664.95
#56	TCF12	17	5	22	869.407
#57	IRF2	17	8	25	1225.838
#58	NFYC	17	5	22	486.576
#59	C5orf41	17	10	27	3331.078
#60	SPI1	17	2	19	129.467
#61	JUNB	17	2	19	874.27
#62	HLF	17	9	26	2551.499
#63	TULP4	17	7	24	641.682
#64	FOXM1	17	3	20	154.953
#65	CBFB	17	4	21	446.015
#66	AHCTF1	17	10	27	2356.359
#67	CREB5	16	10	26	907.107
#68	ATF3	16	5	21	1051.441
#69	GTF2I	16	6	22	1191.322
#70	BACH1	16	7	23	1892.485
#71	IRF9	16	6	22	2412.012
#72	ZNF33A	16	7	23	1236.301
#73	C11orf9	16	8	24	1948.029
#74	ZNF45	16	4	20	810.701
#75	MLL	16	4	20	327.333
#76	SMAD4	16	6	22	1384.717
#77	ZNF91	16	8	24	2611.226
#78	ZNF217	16	10	26	1785.25
#79	AHR	15	14	29	3351.309
#80	ZEB1	15	12	27	3745.598
#81	GTF2H3	15	4	19	201.555
#82	NR4A1	15	1	16	30.722
#83	GLI2	15	7	22	1268.785
#84	KLF9	15	11	26	3180.296
#85	GTF2H2	15	9	24	2455.992
#86	NFATC4	15	11	26	3282.836
#87	FOXN2	15	9	24	1193.343
#88	E2F7	15	5	20	370.42
#89	SCML1	15	5	20	733.405
#90	ECSIT	15	11	26	2534.257
#91	HHEX	15	5	20	329.521
#92	ZBTB48	15	7	22	1842.853
#93	FOXO6	15	13	28	1654.611
#94	NR3C2	15	12	27	1983.977
#95	CSRNP1	15	3	18	190.114
#96	NFIC	15	15	30	1171.397
#97	NFIB	15	6	21	1192.116
#98	SCMH1	14	9	23	531.616
#99	TEAD1	14	5	19	114.351
#100	SOX12	14	5	19	1505.789
#101	GLIS2	14	10	24	2583.949
#102	ESRRA	14	10	24	1496.754
#103	PBX3	14	11	25	1349.901
#104	NFE2L1	14	9	23	1437.806
#105	REL	14	4	18	346.679
#106	TCF3	14	8	22	2695.193
#107	SOX4	14	11	25	2223.683
#108	ENO1	14	10	24	808.706
#109	ATF2	14	4	18	916.322
#110	BCL6	14	15	29	3025.245
#111	STAT2	14	14	28	1321.697
#112	NR2F6	14	7	21	1066.128
#113	ZIC1	14	15	29	6230.201
#114	PTTG1	14	5	19	347.434
#115	GLI3	14	6	20	830.275
#116	ZBTB38	14	5	19	453.122
#117	RBCK1	14	11	25	671.026
#118	HOXB2	14	14	28	5737.095
#119	HMBOX1	13	10	23	1896.756
#120	CREBZF	13	11	24	2515.57
#121	PGR	13	16	29	2983.889
#122	TSC22D3	13	13	26	1982.286
#123	ZEB2	13	4	17	98.868
#124	TRPS1	13	8	21	527.937
#125	SATB1	13	16	29	2437.688
#126	PLSCR1	13	5	18	312.22
#127	BCL3	13	11	24	2017.981
#128	NR3C1	13	11	24	2924.137
#129	ZXDC	12	11	23	1720.004
#130	TRERF1	12	12	24	1886.665
#131	GABPB1	12	5	17	454.988
#132	HMG20B	12	9	21	1206.067
#133	ZNF367	12	3	15	497.315
#134	ZC3H8	12	8	20	628.033
#135	SP1	12	7	19	804.724
#136	MEF2A	12	8	20	1434.918
#137	AFF4	12	9	21	1358.022
#138	ZNF134	12	8	20	889.979
#139	ZNF148	12	9	21	1918.224
#140	KLF2	12	13	25	1825.694
#141	NFATC1	12	7	19	978.821
#142	ZNF189	12	7	19	762.724
#143	ARNT2	12	16	28	3776.981
#144	BTG2	12	7	19	1087.634
#145	MTA3	12	8	20	1606.071
#146	MEF2C	12	13	25	1887.756
#147	MBD1	12	11	23	1662.71
#148	NFATC3	12	7	19	1614.183
#149	MZF1	12	10	22	890.44
#150	HOXB3	12	7	19	925.402
#151	STAT5B	12	13	25	1865.717
#152	PCGF2	12	7	19	1124.569
#153	ZNF33B	12	7	19	694.386
#154	MEIS1	12	12	24	2040.285
#155	CBL	12	8	20	3732.754
#156	UHRF1	12	3	15	346.707
#157	ELF2	12	9	21	3183.693
#158	RB1	12	10	22	1912.038
#159	YBX1	12	7	19	1191.057
#160	GCFC1	12	13	25	2171.885
#161	HOXA5	12	4	16	454.122
#162	RERE	12	8	20	1045.437
#163	TCF7L2	12	9	21	1836.899
#164	BACH2	11	10	21	2681.31
#165	MLLT10	11	11	22	3125.432
#166	NR4A2	11	6	17	2097.723
#167	ZIC2	11	10	21	1100.36
#168	RFXAP	11	11	22	2234.922
#169	HSF2	11	13	24	2451.136
#170	FOXO3	11	10	21	1658.133
#171	TSHZ1	11	10	21	1410.734
#172	HMGB2	11	10	21	1908.02
#173	MEIS2	11	12	23	1228.871
#174	NR2F2	11	10	21	3009.73
#175	NFIA	11	11	22	946.905
#176	CUX1	11	10	21	1597.156
#177	RORA	11	6	17	309.984
#178	TCFL5	11	13	24	758.933
#179	TCEAL1	11	13	24	1379.923
#180	FOSL2	11	8	19	940.7
#181	TFAM	11	6	17	305.103
#182	SOX9	11	12	23	2554.752
#183	KLF7	11	7	18	1127.678
#184	ETS2	11	12	23	2745.778
#185	FOXN3	11	13	24	1437.86
#186	PEG3	11	12	23	2636.921
#187	ETV6	11	8	19	174.113
#188	FBXW7	11	9	20	1229.608
#189	NFYB	10	10	20	647.584
#190	FOS	10	6	16	1551.018
#191	RARA	10	14	24	2057.776
#192	SATB2	10	12	22	1664.615
#193	SHOX	10	6	16	823.544
#194	PHTF1	10	12	22	988.261
#195	ZFPM1	10	10	20	2222.563
#196	ZHX2	10	12	22	2972.942
#197	ZNF117	10	12	22	3036.752
#198	SLC2A4RG	10	8	18	989.335
#199	HOXB7	10	8	18	867.385
#200	PRRX2	10	11	21	2119.131
#201	PLAG1	10	11	21	1100.542
#202	ZNF83	10	18	28	2023.717
#203	HOXC9	10	6	16	1424.683
#204	SLC30A9	10	10	20	1181.406
#205	CEBPD	10	15	25	1352.162
#206	GATA6	10	18	28	3307.236
#207	NOTCH1	10	9	19	1836.947
#208	E2F8	10	6	16	403.81
#209	PGBD1	10	12	22	1162.43
#210	RUNX3	10	13	23	823.371
#211	ETS1	10	10	20	1618.036
#212	BHLHE40	10	9	19	975.761
#213	TARDBP	10	8	18	400.489
#214	CEBPA	10	5	15	257.376
#215	TAF5	10	8	18	522.928
#216	ZFP90	10	15	25	2299.034
#217	TP53	10	10	20	1259.832
#218	NFX1	9	10	19	927.057
#219	ZNF135	9	14	23	2113.902
#220	HOXA7	9	4	13	594.724
#221	KLF4	9	15	24	2063.133
#222	C2orf3	9	10	19	1700.461
#223	ZNF268	9	9	18	814.627
#224	ZNF132	9	3	12	108.531
#225	CITED1	9	10	19	1889.865
#226	FOXP4	9	6	15	782.223
#227	EHF	9	13	22	2088.946
#228	SP4	9	7	16	445.415
#229	FOXP1	9	13	22	1899.691
#230	CDKN2A	9	12	21	1162.767
#231	FOXQ1	9	4	13	683.498
#232	ZNF274	9	10	19	1274.469
#233	EGR1	9	3	12	117.372
#234	SMAD1	9	9	18	1278.301
#235	BATF2	9	9	18	1255.255
#236	TEAD2	9	11	20	4917.044
#237	PHF5A	9	13	22	2152.088
#238	XBP1	9	7	16	1090.334
#239	MAF	9	18	27	2498.715
#240	SP3	9	7	16	706.332
#241	KLF10	9	8	17	1088.103
#242	SIX5	9	11	20	1840.729
#243	ELF3	9	7	16	680.833
#244	KLF12	9	11	20	1301.715
#245	TSHZ3	9	12	21	1699.67
#246	POU2F2	9	7	16	354.484
#247	NR2F1	9	14	23	2258.739
#248	NR1D2	9	7	16	1099.053
#249	SMAD3	9	11	20	2753.238
#250	GAS7	9	12	21	2135.677
#251	SOX13	9	7	16	1362.929
#252	SIX1	9	11	20	1481.482
#253	PITX1	9	10	19	825.539
#254	HOXD13	9	11	20	1630.939
#255	NFYA	9	12	21	1587.482
#256	MSC	9	8	17	389.606
#257	ELK3	9	13	22	1139.772
#258	ZHX3	9	11	20	1769.001
#259	ZRANB2	9	14	23	1353.872
#260	MAFB	9	15	24	1235.809
#261	PBX1	9	13	22	2893.719
#262	FUBP1	9	7	16	605.213
#263	MGA	9	8	17	1277.461
#264	C1orf85	9	12	21	1736.668
#265	ALS2CR8	9	9	18	2492.149
#266	AFF1	8	13	21	1297.168
#267	VTN	8	13	21	747.406
#268	HOXA2	8	13	21	1199.455
#269	PRDM1	8	10	18	617.613
#270	KLF15	8	11	19	966.87
#271	HEY2	8	11	19	1616.76
#272	HOXA3	8	4	12	800.901
#273	DBP	8	18	26	2477.142
#274	TEAD4	8	15	23	3158.91
#275	SREBF2	8	11	19	1404.802
#276	MITF	8	6	14	702.715
#277	ZNF277	8	8	16	742.771
#278	RCOR1	8	7	15	1072.243
#279	ZNF207	8	12	20	2222.349
#280	TBX3	8	11	19	940.827
#281	ZNF174	8	9	17	1098.625
#282	ZNF131	8	13	21	847.884
#283	PKNOX2	8	14	22	1251.412
#284	TFE3	8	14	22	1288.204
#285	MSX2	8	8	16	1098.604
#286	HIRA	8	11	19	755.512
#287	CNOT8	8	7	15	1100.573
#288	NFE2L2	8	13	21	2058.965
#289	YEATS4	8	6	14	672.527
#290	RARG	8	13	21	703.6
#291	ARID3A	8	12	20	1280.57
#292	ZSCAN12	8	10	18	2038.092
#293	SOX17	8	8	16	750.295
#294	PLAGL2	8	11	19	1630.681
#295	BATF	7	11	18	1673.93
#296	TFDP2	7	8	15	1092.845
#297	LHX6	7	7	14	984.326
#298	PAX8	7	14	21	1926.784
#299	TAF5L	7	12	19	815.172
#300	ZNF92	7	12	19	943.675
#301	SIM2	7	7	14	578.483
#302	TADA2A	7	14	21	2244.85
#303	ZNF70	7	11	18	863.411
#304	PPARG	7	11	18	1031.821
#305	LEF1	7	12	19	432.245
#306	SCAND1	7	10	17	1595.035
#307	MMP14	7	14	21	1936.605
#308	CSRNP3	7	16	23	2679.047
#309	HOXA1	7	12	19	805.317
#310	HIF3A	7	17	24	1630.102
#311	NANOG	7	11	18	1014.55
#312	SRF	7	7	14	843.246
#313	RARB	7	15	22	948.009
#314	GATA2	7	11	18	1263.256
#315	HES1	7	11	18	1199.345
#316	FOXC2	7	14	21	979.123
#317	MAFK	7	12	19	1516.951
#318	HMGB1	7	13	20	1078.201
#319	KDM5A	7	4	11	420.397
#320	NR5A2	7	7	14	1150.083
#321	GRHL3	7	10	17	963.414
#322	IRF5	7	8	15	567.352
#323	MKX	7	11	18	933.875
#324	RUNX1T1	6	18	24	1300.2
#325	ZIC3	6	12	18	820.238
#326	TCF7	6	16	22	2092.662
#327	FOSB	6	7	13	771.284
#328	SOX6	6	13	19	1312.004
#329	SIX4	6	14	20	1023.251
#330	IRF6	6	11	17	1017.814
#331	ZNF287	6	11	17	1326.842
#332	TRIM25	6	10	16	1101.905
#333	SIN3A	6	11	17	456.144
#334	HMGA1	6	9	15	1065.419
#335	ZNF256	6	10	16	810.824
#336	HOXA10	6	7	13	656.455
#337	HEY1	6	19	25	3116.51
#338	TBX5	6	4	10	340.571
#339	MYCL1	6	12	18	1238.145
#340	HOPX	6	14	20	254.551
#341	ZNF238	6	10	16	708.653
#342	NKX3-1	6	9	15	445.024
#343	SOX8	6	10	16	1661.137
#344	ETV1	6	10	16	595.364
#345	FOXF2	6	11	17	564.216
#346	TAF10	6	12	18	769.052
#347	JUND	6	10	16	750.726
#348	TFCP2L1	6	8	14	608.309
#349	ATF6B	6	11	17	880.891
#350	FOXO1	6	8	14	904.412
#351	JUN	6	12	18	914.3
#352	HOXB6	6	8	14	992.376
#353	CREB3L2	6	17	23	1742.47
#354	MSRB2	6	13	19	1213.283
#355	PURB	6	9	15	1213.307
#356	ZNF192	6	9	15	560.887
#357	L3MBTL4	6	12	18	1381.467
#358	NFKB2	6	10	16	773.813
#359	NFIL3	6	11	17	2196.514
#360	HOXD8	6	8	14	505.281
#361	ALX1	6	6	12	612.568
#362	RCAN1	5	14	19	842.334
#363	HIC1	5	12	17	1074.874
#364	NEUROD1	5	6	11	549.544
#365	NR1H3	5	14	19	1084.085
#366	MYC	5	16	21	1610.58
#367	RXRA	5	9	14	708.273
#368	TAF13	5	6	11	1200.35
#369	SIX2	5	18	23	3472.685
#370	CITED2	5	15	20	842.715
#371	TCF4	5	11	16	599.908
#372	ZNF167	5	10	15	705.803
#373	ERG	5	12	17	865.198
#374	HES6	5	13	18	1450.093
#375	E2F3	5	8	13	681.394
#376	BCL11B	5	6	11	346.459
#377	TAL1	5	14	19	773.98
#378	TWIST2	5	16	21	654.838
#379	HMGA2	5	15	20	2705.485
#380	EPAS1	5	13	18	933.919
#381	IRF1	5	12	17	774.427
#382	CREB3L1	5	12	17	972.574
#383	DDIT3	5	13	18	1151.652
#384	SALL2	5	15	20	1324.111
#385	TAF4B	5	16	21	430.909
#386	TBX2	5	6	11	443.198
#387	MEIS3P1	5	13	18	892.528
#388	SMAD6	5	17	22	1975.033
#389	KLF6	5	10	15	708.931
#390	ZFP37	5	10	15	622.894
#391	CSDA	5	16	21	659.691
#392	FOXG1	5	16	21	1259.033
#393	ZHX1	5	12	17	2432.92
#394	CBFA2T2	5	15	20	1844.629
#395	ZNF483	4	17	21	954.297
#396	ALX3	4	8	12	553.953
#397	TGIF2	4	14	18	1269.528
#398	ZFHX4	4	13	17	516.696
#399	TEF	4	16	20	1207.548
#400	HOXC10	4	7	11	498.048
#401	GLIS3	4	12	16	1300.284
#402	EGR3	4	4	8	553.458
#403	CTNNB1	4	7	11	1136.364
#404	TBX15	4	8	12	418.557
#405	CNOT7	4	13	17	1495.76
#406	STAT1	4	5	9	110.056
#407	ZNF397	4	8	12	489.045
#408	ZNF154	4	8	12	396.665
#409	ZNF232	4	13	17	1661
#410	ZNF215	4	8	12	530.701
#411	ZIC5	4	10	14	831.996
#412	FOXD3	4	9	13	1341.547
#413	TRIM29	4	9	13	612.869
#414	MEOX2	4	11	15	766.413
#415	FOXC1	4	9	13	564.982
#416	PPARA	4	8	12	295.671
#417	NR2C1	4	19	23	1936.552
#418	NR2E3	4	17	21	1448.941
#419	TCF7L1	4	14	18	504.08
#420	BLZF1	4	13	17	1001.372
#421	SNAI2	4	14	18	750.41
#422	TFAP2B	4	3	7	372.3
#423	NFE2L3	4	12	16	505.53
#424	SPIB	4	10	14	1375.802
#425	ZNF396	4	7	11	1361.038
#426	NR4A3	4	10	14	644.485
#427	PPARD	4	10	14	385.783
#428	FOXS1	4	6	10	302.364
#429	MSX1	4	19	23	1167.615
#430	LASS6	4	12	16	267.535
#431	TGIF1	4	12	16	616.748
#432	ZNF140	3	13	16	364.916
#433	TAF1B	3	6	9	411.186
#434	TBX1	3	8	11	1052.239
#435	TSC22D1	3	13	16	1004.834
#436	ZSCAN16	3	10	13	446.92
#437	FOXD1	3	12	15	377.718
#438	BHLHE41	3	14	17	199.476
#439	FOXK1	3	7	10	538.394
#440	ZFP36L2	3	10	13	473.469
#441	CUX2	3	10	13	416.131
#442	SALL1	3	17	20	586.206
#443	KLF11	3	13	16	477.79
#444	FOXD2	3	12	15	378.077
#445	FOSL1	3	11	14	916.508
#446	SCAND3	3	5	8	317.006
#447	ZNF323	3	12	15	1384.612
#448	STAT3	3	11	14	626.337
#449	PBX2	3	9	12	468.493
#450	TCF19	3	15	18	608.921
#451	TCF15	3	11	14	534.361
#452	ZNF281	3	15	18	1367.066
#453	RBPJ	3	10	13	262.93
#454	NPAS2	3	11	14	682.198
#455	STAT4	3	8	11	271.845
#456	GATAD2B	2	8	10	298.354
#457	WNT5A	2	18	20	1043.087
#458	GATA3	2	15	17	1194.65
#459	PAX6	2	12	14	120.102
#460	CTBP1	2	8	10	496.815
#461	POU6F2	2	10	12	372.364
#462	ESR1	2	11	13	451.195
#463	FOXL1	2	10	12	481.925
#464	LCOR	2	9	11	508.792
#465	VDR	2	11	13	233.743
#466	ZNF24	2	12	14	325.024
#467	MECOM	2	19	21	613.93
#468	FOXP2	2	21	23	955.516
#469	MXD1	2	10	12	609.996
#470	BRD8	2	16	18	776.725
#471	ZNF37A	2	7	9	363.345
#472	ZFPM2	2	15	17	1630.64
#473	DMRT1	2	5	7	513.696
#474	EGR2	2	7	9	125.057
#475	ARNT	2	11	13	306.024
#476	USF1	2	7	9	346.59
#477	ADNP2	2	9	11	141.724
#478	FOXL2	2	12	14	525.628
#479	NPAS1	2	10	12	1944.074
#480	STRN3	2	9	11	844.387
#481	ETV5	2	17	19	263.161
#482	CREM	2	12	14	255.341
#483	ISL2	2	10	12	281.02
#484	SIX3	2	11	13	407.504
#485	E2F5	1	16	17	202.952
#486	JDP2	1	16	17	671.998
#487	ZFP36L1	1	12	13	61.491
#488	TSC22D2	1	11	12	118.506
#489	HEYL	1	8	9	201.261
#490	IRX5	1	13	14	98.794
#491	IRX3	1	11	12	682.471
#492	MAFG	1	11	12	130.953
#493	ARX	1	10	11	53.781
#494	SREBF1	0	14	14	0
#495	ESRRG	0	15	15	0
#496	EN1	0	12	12	0
#497	ARNTL	0	14	14	0
#498	ZNF35	0	9	9	0
#499	PTH	0	5	5	0
#500	NPAT	0	8	8	0