Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	RUNX2	57	4	61	1006.022
#2	BTG2	48	6	54	3940.692
#3	MEIS2	47	8	55	1275.937
#4	CREB3L1	46	7	53	1630.834
#5	VAV1	43	3	46	349.586
#6	ELK3	43	6	49	3482.981
#7	ZNF148	41	5	46	843.687
#8	MAFB	40	11	51	6512.704
#9	MBD1	40	1	41	67.489
#10	KLF15	39	11	50	2772.762
#11	JUNB	39	2	41	373.865
#12	ZNF367	38	3	41	284.608
#13	IRF8	38	1	39	55.921
#14	PBX1	37	6	43	795.941
#15	TBX1	36	8	44	3454.704
#16	SP1	36	2	38	34.859
#17	CEBPB	36	8	44	3825.307
#18	HCLS1	35	3	38	2486.627
#19	SALL2	35	14	49	4746.23
#20	KLF4	34	5	39	569.237
#21	CREB5	34	9	43	1446.258
#22	CREB1	34	7	41	1034.35
#23	FOSL1	34	11	45	2036.542
#24	ZNF397	33	13	46	1565.819
#25	MAX	33	7	40	374.58
#26	MEIS1	33	5	38	289.655
#27	ELF1	33	16	49	2069.736
#28	CREBL2	32	6	38	1146.126
#29	BATF	32	7	39	797.954
#30	GABPB1	32	8	40	1733.719
#31	GLI3	32	8	40	1177.976
#32	FLI1	32	6	38	981.738
#33	TCF7L1	31	9	40	1127.415
#34	POU2F1	31	5	36	1419.95
#35	ATF1	30	4	34	645.32
#36	HIC1	30	11	41	1897.741
#37	TRIM22	30	11	41	3692.736
#38	TCF19	30	6	36	2007.588
#39	IRF1	30	3	33	923.912
#40	SATB1	30	11	41	716.204
#41	NFIA	30	8	38	1733.935
#42	GTF2I	29	2	31	2053.42
#43	TCF4	29	11	40	1259.515
#44	TCEAL1	29	7	36	473.063
#45	GAS7	29	18	47	1799.59
#46	NOLC1	29	4	33	146.736
#47	HMGA1	29	7	36	565.81
#48	NFAT5	28	9	37	845.88
#49	TCF7L2	28	9	37	1401.179
#50	HOXC13	28	7	35	745.662
#51	SPEN	28	6	34	495.317
#52	LZTS1	28	10	38	1279.232
#53	MYC	28	8	36	1527.856
#54	THRA	28	11	39	1558.133
#55	BCL3	28	8	36	389.845
#56	CREM	28	14	42	1331.378
#57	RELA	27	8	35	402.511
#58	NR3C1	27	9	36	1327.599
#59	STAT1	27	3	30	96.945
#60	SMAD2	27	10	37	3549.904
#61	KLF6	27	6	33	477.75
#62	HMGB2	26	2	28	287.107
#63	JDP2	26	11	37	1727.32
#64	GATAD2B	26	7	33	1020.794
#65	TARDBP	25	18	43	1439.048
#66	PLSCR1	25	9	34	986.607
#67	NFIB	25	10	35	987.318
#68	CSRNP1	25	3	28	73.792
#69	VDR	25	3	28	526.273
#70	STAT5A	25	7	32	787.714
#71	ATF2	25	6	31	232.679
#72	ZSCAN2	25	9	34	551.643
#73	LEF1	25	13	38	1727.293
#74	FOXF1	24	14	38	1588.367
#75	NFKB1	24	13	37	974.29
#76	ATF3	24	3	27	289.21
#77	ELF4	24	14	38	2002.277
#78	KDM5B	24	15	39	2039.164
#79	SIX2	24	15	39	1445.392
#80	FOSL2	24	18	42	1437.526
#81	ETS1	24	11	35	1586.768
#82	MEF2C	24	19	43	2298.042
#83	HIF3A	23	9	32	1599.081
#84	GLIS3	23	12	35	1295.344
#85	MGA	23	7	30	1446.256
#86	ETS2	23	15	38	1558.542
#87	EBF1	23	10	33	817.927
#88	NR3C2	23	15	38	5387.39
#89	TEAD4	22	12	34	1158.66
#90	FOXO6	22	13	35	1667.906
#91	RUNX1	22	14	36	897.347
#92	NFIX	22	15	37	944.337
#93	HOXA10	22	5	27	268.673
#94	UHRF1	22	8	30	577.512
#95	MYOD1	22	3	25	652.024
#96	IKZF1	22	5	27	57.108
#97	TULP4	21	4	25	423.194
#98	SMAD3	21	8	29	549.689
#99	HDAC1	21	15	36	1538.577
#100	FOXM1	21	5	26	1170.571
#101	ZKSCAN1	21	11	32	1153.75
#102	RERE	21	4	25	714.298
#103	SIX4	21	13	34	719.292
#104	HLF	20	13	33	970.329
#105	TFEC	20	6	26	116.912
#106	KLF3	20	15	35	979.894
#107	NR2F2	20	13	33	1551.056
#108	MLL	20	12	32	909.139
#109	MMP14	20	11	31	1050.341
#110	STAT5B	20	13	33	891.932
#111	PRRX1	20	15	35	1776.255
#112	ETV6	20	13	33	2380.546
#113	TSHZ1	20	14	34	1270.613
#114	BCL6	20	14	34	1924.55
#115	JUND	20	9	29	611.78
#116	PEG3	20	12	32	1239.295
#117	HEY2	20	11	31	1870.569
#118	MYCN	19	6	25	2676.272
#119	ZSCAN18	19	21	40	3462.762
#120	TWIST1	19	11	30	564.259
#121	NFIC	19	10	29	944.768
#122	UBN1	19	9	28	306.645
#123	ZNF24	19	10	29	2107.033
#124	PTTG1	19	1	20	140.434
#125	AFF4	19	7	26	346.072
#126	C5orf41	19	18	37	1795.111
#127	FOXL2	19	9	28	646.748
#128	ZNF281	19	17	36	3136.516
#129	KLF9	19	17	36	2113.747
#130	NFIL3	18	7	25	1870.984
#131	EN1	18	17	35	3272.843
#132	TAF5	18	11	29	691.742
#133	CEBPD	18	16	34	1407.19
#134	SOX4	18	16	34	1470.431
#135	IRF6	18	13	31	1787.11
#136	YEATS4	18	11	29	2909.132
#137	NFX1	18	6	24	4020.366
#138	HOXA3	18	21	39	2448.007
#139	TFE3	18	11	29	1530.826
#140	CNOT8	18	5	23	322.71
#141	CTNNB1	18	6	24	740.578
#142	STAT3	18	8	26	611.036
#143	MLLT10	18	11	29	1751.36
#144	PRRX2	18	13	31	2077.905
#145	C1orf85	18	17	35	2186.475
#146	RB1	18	9	27	702.528
#147	HEY1	18	15	33	2611.327
#148	PBX2	17	7	24	793.121
#149	SNAI2	17	12	29	718.322
#150	ZFP90	17	14	31	1112.362
#151	ZNF117	17	9	26	667.063
#152	SOX8	17	14	31	1874.918
#153	HOXC4	17	11	28	849.176
#154	TFAM	17	9	26	620.667
#155	ZNF238	17	18	35	1889.657
#156	SOX15	17	9	26	1414.804
#157	FOSB	17	5	22	1510.04
#158	ZNF207	17	9	26	966.241
#159	GCFC1	17	9	26	3543.304
#160	SCMH1	17	12	29	925.951
#161	ZBTB38	17	9	26	891.527
#162	PLAG1	17	17	34	2041.444
#163	NFKB2	16	7	23	498.106
#164	ZFP37	16	19	35	3357.566
#165	KLF2	16	13	29	702.053
#166	RCAN1	16	13	29	1457.545
#167	HOXA5	16	10	26	891.326
#168	HOXC11	16	11	27	1821.829
#169	FOS	16	1	17	298.998
#170	IKZF4	16	13	29	1250.306
#171	PKNOX2	15	17	32	1539.387
#172	ZNF75D	15	12	27	931.856
#173	TRERF1	15	12	27	1168.02
#174	HOXD4	15	17	32	2495.326
#175	ADNP2	15	11	26	936.952
#176	ZGPAT	15	20	35	1227.501
#177	GATAD1	15	11	26	1053.683
#178	EN2	15	12	27	1478.631
#179	TFCP2	15	3	18	23.211
#180	HHEX	15	12	27	394.369
#181	RXRB	15	5	20	111.664
#182	SIN3A	15	11	26	1105.862
#183	SIM2	15	18	33	2405.821
#184	FOXE1	15	10	25	1164.9
#185	STAT4	15	11	26	1558.815
#186	CBL	15	6	21	965.422
#187	SIX5	15	13	28	699.059
#188	TRIM25	15	12	27	1301.644
#189	TCF12	14	13	27	2227.212
#190	PCGF2	14	14	28	896.076
#191	MSL3	14	15	29	1124.092
#192	HOXA9	14	7	21	711.153
#193	FOXC2	14	19	33	2797.306
#194	IRX2	14	11	25	2529.549
#195	TAF4B	14	19	33	1067.299
#196	FOXP4	14	16	30	1457.948
#197	ZNF167	14	19	33	1021.444
#198	SMAD1	14	17	31	343.914
#199	BHLHE40	14	17	31	1067.083
#200	ZEB2	14	19	33	3875.654
#201	MITF	14	19	33	1524.291
#202	DLX6	14	22	36	2753.863
#203	AHR	14	16	30	1217.803
#204	CBFB	14	13	27	867.426
#205	TEAD2	14	14	28	1967.07
#206	GABPA	14	10	24	290.865
#207	HOXC9	14	18	32	1777.687
#208	E2F7	14	7	21	467.473
#209	NANOGNB	14	11	25	1105.027
#210	TEAD3	14	14	28	602.574
#211	NR1H3	14	9	23	856.964
#212	IRF7	14	8	22	2222.977
#213	RELB	14	8	22	578.588
#214	IRX4	13	10	23	1520.693
#215	HOPX	13	17	30	1250.265
#216	SMAD9	13	21	34	1417.143
#217	NR4A2	13	8	21	315.766
#218	MAFF	13	10	23	1729.511
#219	PGR	13	19	32	1337.473
#220	IRX3	13	14	27	1418.051
#221	CEBPA	13	8	21	200.73
#222	TFAP2A	13	17	30	721.365
#223	CSRNP3	13	19	32	2025.862
#224	MEIS3P1	13	23	36	1602.707
#225	TRPS1	13	17	30	1313.594
#226	E2F8	13	7	20	549.149
#227	PAX7	13	9	22	291.641
#228	ETV5	13	21	34	2570.441
#229	STAT6	13	15	28	801.392
#230	ZNF83	13	15	28	469.55
#231	ZNF93	13	17	30	1797.512
#232	EPAS1	13	11	24	1712.425
#233	PRDM2	13	21	34	917.499
#234	ZNF232	13	14	27	1867.391
#235	ZHX1	13	11	24	1525.003
#236	NCOR1	13	11	24	1290.129
#237	BATF3	13	19	32	1311.538
#238	HMG20B	13	12	25	1348.943
#239	SOX17	13	10	23	529.947
#240	ZNF217	13	14	27	1057.563
#241	AHCTF1	13	15	28	707.868
#242	TSC22D4	13	18	31	1433.669
#243	IRF9	12	5	17	142.133
#244	FOXL1	12	12	24	817.017
#245	CSRNP2	12	20	32	1122.306
#246	E2F3	12	17	29	1709.551
#247	STAT2	12	11	23	995.544
#248	PPARG	12	14	26	1839.928
#249	DLX4	12	11	23	978.329
#250	ZNF500	12	19	31	1470.232
#251	EGR2	12	17	29	513.041
#252	ETV3	12	10	22	1485.968
#253	TCF7	12	20	32	968.838
#254	C12orf28	12	17	29	1788.062
#255	ZNF498	12	18	30	980.205
#256	PBX3	12	17	29	844.777
#257	ETV1	11	16	27	852.468
#258	ALX1	11	10	21	610.147
#259	SNAPC4	11	20	31	1581.545
#260	LHX6	11	12	23	1638.354
#261	JUN	11	15	26	440.97
#262	ELK1	11	17	28	1580.787
#263	FUBP1	11	23	34	2401.866
#264	REL	11	9	20	427.825
#265	SIX1	11	13	24	929.72
#266	E2F6	11	21	32	1826.953
#267	TP53	11	15	26	2931.399
#268	ZNF277	11	12	23	696.08
#269	KLF11	11	17	28	1752.875
#270	GLIS2	11	17	28	790.595
#271	CREB3L4	11	16	27	986.469
#272	NKX3-1	11	9	20	476.166
#273	ZFP36L2	11	17	28	902.439
#274	MEF2A	10	18	28	1048.727
#275	CITED2	10	17	27	1044.138
#276	HOXD13	10	14	24	662.489
#277	HOXA1	10	15	25	1354.098
#278	GATA3	10	13	23	1105.017
#279	ZNF131	10	14	24	289.905
#280	AEBP1	10	19	29	1404.294
#281	FOXO1	10	18	28	1214.17
#282	HOXD8	10	15	25	1920.706
#283	ATF6	10	20	30	3005.611
#284	MYF5	10	10	20	899.741
#285	ARNTL2	10	16	26	2712.203
#286	FOXD1	10	18	28	1400.029
#287	ZNF91	10	25	35	1239.034
#288	BACH2	10	16	26	639.88
#289	FOXN3	10	19	29	1929.547
#290	EGR1	10	7	17	371.724
#291	RXRG	9	12	21	502.555
#292	XBP1	9	14	23	639.36
#293	SMAD5	9	14	23	604.372
#294	ZEB1	9	8	17	97.495
#295	SMAD6	9	15	24	862.37
#296	MSRB2	9	16	25	661.178
#297	ISL1	9	23	32	1343.381
#298	KLF7	9	17	26	1240.643
#299	IRF4	9	16	25	948.724
#300	NFE2L3	9	10	19	678.856
#301	NOTCH1	9	15	24	1065.341
#302	TSHZ3	9	20	29	690.824
#303	NR4A1	9	7	16	232.869
#304	NPAS2	9	19	28	726.735
#305	HOXB3	9	15	24	636.151
#306	PURA	9	17	26	684.988
#307	TCFL5	9	23	32	1446.148
#308	BCL11B	9	9	18	520.932
#309	NFYB	9	9	18	455.468
#310	ZFHX4	9	18	27	1255.835
#311	ZFPM2	9	20	29	1274.187
#312	HOXB7	9	19	28	871.438
#313	TSC22D3	9	17	26	1640.029
#314	BATF2	9	14	23	999.111
#315	NFATC4	9	17	26	1273.837
#316	SP140	9	8	17	127.94
#317	MKX	8	17	25	1140.378
#318	FOXP1	8	23	31	1780.725
#319	NR1D2	8	14	22	948.745
#320	BNC1	8	15	23	1501.956
#321	TFAP2C	8	15	23	3049.84
#322	SOX7	8	15	23	1270.681
#323	SOLH	8	24	32	1332.398
#324	TSHZ2	8	21	29	727.675
#325	ZNF18	8	13	21	484.689
#326	ZNF70	8	21	29	1760.413
#327	NKX3-2	8	16	24	1326.327
#328	ARNT2	8	15	23	1380.333
#329	PROX1	8	8	16	640.472
#330	EOMES	8	7	15	80.52
#331	MYBL2	8	7	15	1075.265
#332	MYNN	8	14	22	1181.237
#333	SOX6	8	25	33	1864.547
#334	ESR1	8	19	27	879.336
#335	GTF2IRD1	8	16	24	484.603
#336	BHLHE41	8	18	26	1263.149
#337	PRDM1	8	15	23	294.471
#338	TWIST2	8	20	28	1687.037
#339	KLF12	8	18	26	2226.66
#340	ZNF496	8	16	24	951.139
#341	TGIF2	8	16	24	519.777
#342	ZNF133	8	18	26	805.919
#343	RFX5	8	18	26	865.398
#344	MAFK	8	15	23	878.576
#345	HMGA2	8	16	24	1818.845
#346	ZNF639	8	8	16	373.022
#347	SCML1	7	22	29	3822.019
#348	RARB	7	20	27	711.952
#349	NFYA	7	18	25	538.895
#350	GATA2	7	16	23	743.28
#351	CSDA	7	17	24	744.441
#352	L3MBTL4	7	21	28	1495.007
#353	TFDP1	7	19	26	1368.366
#354	TBX15	7	16	23	548.281
#355	HOXA7	7	12	19	399.159
#356	SOX2	7	16	23	1106.909
#357	ATF5	7	22	29	860.801
#358	MSC	7	20	27	760.341
#359	RUNX1T1	7	23	30	1958.061
#360	ZBTB25	7	20	27	921.416
#361	NR4A3	7	11	18	184.68
#362	CBFA2T3	7	10	17	459.748
#363	NFATC2	7	12	19	1722.557
#364	PHTF1	7	14	21	741.561
#365	HES6	7	22	29	2514.465
#366	DLX2	7	10	17	589.218
#367	SIM1	7	14	21	943.734
#368	C11orf9	7	18	25	1154.73
#369	ZFHX3	7	24	31	1112.926
#370	STRN3	7	13	20	762.586
#371	EGR3	7	9	16	156.795
#372	EGR4	7	8	15	575.745
#373	PURB	7	22	29	751.294
#374	CREBZF	7	14	21	3143.063
#375	SLC30A9	7	16	23	668.064
#376	PHF5A	7	11	18	141.116
#377	LHX8	7	16	23	1541.514
#378	ZXDA	7	18	25	954.879
#379	NANOG	7	19	26	395.291
#380	ZIC2	6	9	15	388.963
#381	DDIT3	6	21	27	1259.713
#382	HEYL	6	18	24	570.176
#383	NR2F1	6	25	31	1481.34
#384	CBFA2T2	6	15	21	292.641
#385	HOXB2	6	11	17	495.383
#386	TEF	6	13	19	2098.851
#387	NR2C1	6	12	18	975.653
#388	ZNF438	6	24	30	592.956
#389	PAX8	6	18	24	337.458
#390	NFATC3	6	10	16	379.716
#391	DLX1	6	15	21	1207.479
#392	ESRRG	6	14	20	1095.923
#393	FOXK2	6	18	24	937.891
#394	TAF1B	6	12	18	825.839
#395	NFATC1	6	26	32	845.015
#396	TBX5	6	15	21	682.436
#397	IRX1	6	19	25	719.222
#398	HOXD11	6	4	10	280.179
#399	IRF5	6	4	10	112.015
#400	CDKN2A	6	21	27	1016.757
#401	WNT5A	6	24	30	717.392
#402	DBP	6	17	23	399.524
#403	TBX2	6	22	28	1452.33
#404	ZNF274	6	18	24	3040.607
#405	MSX1	6	24	30	1330.217
#406	TCF21	6	23	29	1459.377
#407	GATA6	6	18	24	325.834
#408	GTF2H4	6	17	23	205.455
#409	FOXQ1	6	18	24	754.992
#410	TFDP2	5	16	21	564.299
#411	NFXL1	5	20	25	1279.784
#412	ZXDC	5	18	23	900.57
#413	ZNF202	5	23	28	810.49
#414	FOXF2	5	18	23	472.048
#415	TP63	5	22	27	1103.057
#416	SALL1	5	17	22	920.554
#417	ENO1	5	22	27	414.129
#418	SLC2A4RG	5	15	20	601.811
#419	HOXA11	5	13	18	590.958
#420	ZNF140	5	15	20	538.131
#421	ERG	5	14	19	637.398
#422	HOXC10	5	11	16	383.792
#423	ZHX2	5	25	30	844.82
#424	MECOM	5	19	24	353.314
#425	HOXB6	5	18	23	704.483
#426	RORB	5	14	19	1308.444
#427	ZNF45	5	14	19	1018.443
#428	HOXD3	5	15	20	1096.725
#429	PPARA	5	22	27	469.781
#430	TCF3	5	19	24	706.892
#431	FOXS1	5	9	14	423.31
#432	SP3	5	19	24	1712.996
#433	RBCK1	5	24	29	1757.354
#434	ZNF287	5	18	23	928.798
#435	CNOT7	4	18	22	168.672
#436	SMAD4	4	17	21	612.383
#437	SOX11	4	22	26	1077.872
#438	LASS6	4	20	24	643.105
#439	TSC22D1	4	21	25	807.014
#440	MEIS3	4	19	23	263.609
#441	FOXC1	4	29	33	604.895
#442	KLF5	4	18	22	696.701
#443	LHX2	4	25	29	400.567
#444	ZRANB2	4	16	20	827.455
#445	ERF	4	13	17	205.278
#446	PITX2	4	16	20	579.903
#447	RORA	4	21	25	649.846
#448	NFYC	4	14	18	629.035
#449	MYPOP	4	13	17	459.705
#450	HOXD1	4	15	19	303.427
#451	MSX2	4	18	22	483.009
#452	CREB3	4	16	20	270.233
#453	TFEB	4	26	30	924.931
#454	CREB3L2	4	20	24	503.91
#455	POU6F1	4	20	24	182.613
#456	MEOX2	4	23	27	903.88
#457	GLI2	4	25	29	381.646
#458	ZHX3	4	19	23	775.506
#459	LMO4	4	19	23	396.852
#460	SOX9	4	20	24	400.755
#461	ARNT	4	14	18	265.438
#462	MXD1	3	15	18	99.932
#463	PAX6	3	21	24	742.197
#464	DMRT2	3	17	20	253.061
#465	SATB2	3	24	27	230.829
#466	HOXA2	3	17	20	473.335
#467	SCAND1	3	14	17	486.231
#468	HOXD10	3	14	17	765.742
#469	NFE2L2	3	20	23	699.518
#470	AR	3	18	21	249.029
#471	HES1	3	15	18	561.064
#472	MEOX1	3	17	20	345.337
#473	IRX5	3	15	18	458.415
#474	MYF6	3	10	13	298.797
#475	ARNTL	3	21	24	332.395
#476	SOX13	3	18	21	726.041
#477	ZFP36L1	3	17	20	384.264
#478	WT1	3	21	24	433.538
#479	RARA	3	22	25	1062.674
#480	FOXG1	3	19	22	681.528
#481	TGIF1	3	20	23	665.089
#482	MAF	3	26	29	578.392
#483	FOXP2	2	18	20	384.084
#484	ATF7	2	17	19	286.586
#485	ZNF323	2	19	21	2126.495
#486	KDM5A	2	16	18	118.019
#487	PAX3	2	25	27	271.096
#488	TBX3	2	19	21	469.06
#489	SREBF1	2	19	21	460.121
#490	SIX3	2	11	13	399.126
#491	LHX9	2	16	18	389.387
#492	RUNX3	2	21	23	520.284
#493	THRB	2	14	16	111.639
#494	HMBOX1	2	16	18	492.608
#495	ZNF85	1	12	13	59.696
#496	NR1H4	1	17	18	116.216
#497	ZIC1	1	25	26	176.818
#498	ZC3H8	1	19	20	290.307
#499	ZNF268	0	18	18	0
#500	CTBP1	0	20	20	0