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Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	KDM5B	49	5	54	3433.181
#2	FOXM1	42	1	43	184.628
#3	HOXA9	41	2	43	289.34
#4	ENO1	40	2	42	897.36
#5	STAT3	39	2	41	608.737
#6	SOX4	39	4	43	1361.947
#7	FOXK2	37	4	41	6064.211
#8	SMAD1	34	8	42	5075.331
#9	SOX9	32	6	38	5221.479
#10	BCL6	31	8	39	698.695
#11	FOXO3	30	3	33	333.748
#12	KLF3	30	5	35	10154.465
#13	CNOT8	28	5	33	4965.099
#14	ZNF148	28	4	32	1577.974
#15	CITED2	27	3	30	467.519
#16	ZFP36L1	27	3	30	858.925
#17	CSDA	27	5	32	1074.411
#18	TSC22D1	26	5	31	796.413
#19	HIF3A	26	1	27	222.62
#20	MSRB2	25	9	34	5069.713
#21	RUNX1	24	9	33	1581.867
#22	SMAD4	24	4	28	3236.026
#23	TGIF1	24	3	27	60.926
#24	CREM	24	4	28	789.38
#25	NR4A2	23	9	32	668.24
#26	TAF5	23	8	31	484.76
#27	EGR1	22	8	30	3909.076
#28	GATA6	22	5	27	703.312
#29	ZNF33A	22	5	27	2008.466
#30	MSX1	22	7	29	684.435
#31	NFYB	22	2	24	845.137
#32	TP53	21	6	27	966.284
#33	HSF2	21	4	25	564.018
#34	RFXAP	21	5	26	2149.505
#35	TFAP2A	21	8	29	6285.051
#36	AHR	21	5	26	666.999
#37	HSF1	21	2	23	48.017
#38	JUNB	21	7	28	2099.793
#39	ZFP90	21	7	28	2748.079
#40	UHRF1	20	7	27	3604.817
#41	ZNF24	20	8	28	4430.754
#42	KLF4	20	3	23	911.367
#43	NFYC	20	10	30	10586.624
#44	HMG20B	20	5	25	10279.002
#45	E2F4	19	6	25	3325.952
#46	CTBP1	19	9	28	3249.906
#47	ZNF444	19	5	24	581.143
#48	SIN3A	19	5	24	1937.155
#49	AHCTF1	19	8	27	5148.176
#50	CBFB	19	5	24	767.985
#51	HNF1B	19	8	27	2548.239
#52	ZNF217	19	5	24	844.497
#53	MYBL2	19	5	24	378.188
#54	AFF1	19	6	25	1971.616
#55	TAF4B	18	8	26	1712.813
#56	EDF1	18	7	25	1566.087
#57	HMGA2	18	7	25	4000.068
#58	CREBZF	18	7	25	1460.22
#59	SIX4	18	6	24	654.167
#60	GAS7	18	4	22	3772.613
#61	CSRNP1	18	7	25	1696.977
#62	YEATS4	17	1	18	11.416
#63	SNAPC5	17	5	22	1012.024
#64	JUND	17	8	25	9325.772
#65	CEBPB	17	9	26	736.876
#66	NR2C2	17	4	21	3479.081
#67	MKX	17	6	23	2198.726
#68	MSX2	17	3	20	94.154
#69	NR3C1	17	6	23	1467.298
#70	LMO4	17	9	26	5099.867
#71	HMGA1	17	6	23	264.563
#72	PCGF2	17	9	26	2816.144
#73	ZIC2	16	6	22	141.347
#74	HNRNPAB	16	9	25	2732.913
#75	NPAT	16	4	20	1740.638
#76	NR2F1	16	3	19	146.684
#77	TSHZ1	16	8	24	1380.817
#78	NFE2L2	16	10	26	24087.355
#79	HMGB2	16	7	23	1199.334
#80	BTG2	16	6	22	1658.247
#81	SALL2	16	3	19	140.653
#82	KLF10	16	8	24	3023.05
#83	MAX	16	6	22	1457.781
#84	TADA3	16	8	24	5340.88
#85	ATF4	15	5	20	2172.273
#86	BACH1	15	8	23	2406.251
#87	NR1D2	15	9	24	1612.998
#88	TEAD4	15	6	21	960.168
#89	TCF12	15	8	23	2366.107
#90	BLZF1	15	9	24	2740.817
#91	EHF	15	4	19	3528.429
#92	LASS6	15	4	19	3017.857
#93	SMAD5	15	7	22	2828.456
#94	EPAS1	15	5	20	287.687
#95	STAT1	15	8	23	4146.553
#96	GTF2I	15	2	17	475.561
#97	HMGB1	15	3	18	221.679
#98	SATB2	15	9	24	1252.505
#99	CREB3L2	14	5	19	565.772
#100	POU3F1	14	3	17	5196.168
#101	PKNOX1	14	12	26	9499.868
#102	ZNF236	14	5	19	583.369
#103	MTF1	14	10	24	3994.043
#104	PA2G4	14	12	26	796.809
#105	TFCP2	14	8	22	3716.546
#106	NR2C1	14	11	25	3305.372
#107	GABPA	14	6	20	2979.14
#108	MGA	14	7	21	1972.378
#109	NFATC1	14	7	21	3385.696
#110	NFYA	14	9	23	2250.958
#111	PHF5A	13	3	16	432.813
#112	TFDP1	13	7	20	700.065
#113	ATF1	13	6	19	729.094
#114	ZNF207	13	5	18	654.63
#115	MAFF	13	9	22	2965.913
#116	CREB3	13	12	25	1679.167
#117	MEIS2	13	6	19	3999.777
#118	NFIB	13	7	20	2978.617
#119	ELF2	13	7	20	1885.442
#120	ARNTL	13	10	23	1412.076
#121	ZNF83	13	8	21	1963.783
#122	MEF2A	13	6	19	1126.165
#123	AFF4	13	8	21	1598.043
#124	REST	13	4	17	1047.806
#125	SIX1	13	12	25	2164.237
#126	TCF7L2	12	10	22	7421.103
#127	PPARA	12	7	19	430.539
#128	USF2	12	9	21	5832.438
#129	KLF6	12	8	20	1875.812
#130	PLAGL2	12	9	21	5378.474
#131	NR2F6	12	6	18	1964.139
#132	ATF2	12	5	17	474.467
#133	SP1	12	9	21	1373.387
#134	YBX1	12	5	17	3858.793
#135	TAF7	12	9	21	2490.635
#136	HMG20A	11	9	20	2425.555
#137	HOXB7	11	13	24	10665.236
#138	BRD8	11	7	18	1861.012
#139	ZNF165	11	10	21	3644.347
#140	FOXN3	11	6	17	1538.481
#141	MESP1	11	7	18	667.066
#142	KLF9	11	6	17	227.7
#143	UBP1	11	6	17	1831.457
#144	GTF2H2	11	9	20	5053.805
#145	TRIM25	11	9	20	1084.49
#146	ZBTB38	11	10	21	726.256
#147	TRIM28	11	9	20	8184.919
#148	NOLC1	11	11	22	2515.948
#149	HOXB8	11	14	25	7240.701
#150	PLSCR1	11	7	18	1225.069
#151	STAT2	11	12	23	1265.294
#152	ZNF138	11	11	22	2715.671
#153	FUBP1	11	7	18	752.412
#154	DLX2	10	12	22	3626.607
#155	CREB1	10	4	14	563.044
#156	RBPJ	10	10	20	1190.239
#157	NFE2L3	10	9	19	2023.235
#158	ZNF277	10	8	18	3204.259
#159	TSC22D2	10	10	20	1666.856
#160	HCFC1	10	8	18	2546.469
#161	FOXP4	10	11	21	1253.947
#162	PURB	10	10	20	2428.701
#163	C5orf41	10	10	20	4348.139
#164	E2F7	10	9	19	3818.791
#165	ZNF45	10	8	18	300.784
#166	ADNP	10	8	18	1106.614
#167	TAF12	10	11	21	7696.91
#168	LHX2	10	11	21	2128.578
#169	ISL2	9	9	18	576.522
#170	TEAD1	9	7	16	842.236
#171	IRF3	9	5	14	1861.688
#172	TFAP2C	9	11	20	399.524
#173	CTNNB1	9	12	21	7938.599
#174	SLC30A9	9	7	16	2831.077
#175	FBXW7	9	10	19	2381.304
#176	TAF10	9	10	19	3136.663
#177	NPAS2	9	7	16	3243.885
#178	FOXD1	9	8	17	964.154
#179	SOX10	9	4	13	149.86
#180	RUNX3	9	5	14	1242.37
#181	MLL	9	11	20	1754.129
#182	KLF12	9	11	20	1736.902
#183	ZEB1	9	12	21	3886.119
#184	E2F5	9	8	17	7376.689
#185	ZNF70	8	9	17	1062.583
#186	ARID4A	8	8	16	1370.223
#187	FOXO1	8	9	17	2254.209
#188	ZFP36L2	8	8	16	1139.89
#189	BTAF1	8	12	20	6343.519
#190	STRN3	8	10	18	1932.166
#191	ATF7	8	4	12	310.66
#192	VDR	8	11	19	1804.6
#193	MYNN	8	7	15	317.854
#194	ZNF394	8	10	18	3863.433
#195	TCF7L1	8	10	18	3104.805
#196	ECSIT	8	10	18	819.763
#197	HOXB9	8	8	16	3850.565
#198	C11orf9	8	9	17	2010.468
#199	NR1H3	8	12	20	7562.091
#200	PRRX2	8	8	16	7390.986
#201	FOS	7	10	17	4666.637
#202	HES1	7	6	13	402.778
#203	CNBP	7	13	20	3124.961
#204	ZKSCAN1	7	10	17	5862.251
#205	CCRN4L	7	9	16	683.841
#206	ETV4	7	13	20	2520.009
#207	GATAD1	7	15	22	4042.254
#208	HOXB3	7	12	19	1009.102
#209	CTCF	7	10	17	1555.973
#210	HOXB4	7	11	18	10301.805
#211	RUNX2	7	13	20	1080.309
#212	SOX13	7	6	13	2883.244
#213	PITX2	7	8	15	1540.468
#214	RFX5	7	6	13	198.018
#215	ZNF213	7	9	16	2016.451
#216	NFIL3	7	6	13	542.53
#217	TCF20	7	12	19	1417.082
#218	NR2F2	7	8	15	778.074
#219	TAF4	7	12	19	1299.401
#220	DMTF1	7	4	11	1307.589
#221	ADNP2	7	8	15	2192.963
#222	TBP	7	7	14	1729.809
#223	IRF7	7	7	14	602.696
#224	ETS1	7	7	14	363.424
#225	ELF1	7	13	20	10026.393
#226	KLF11	7	8	15	1462.703
#227	ZNF131	6	9	15	1015.881
#228	NKX3-1	6	10	16	877.094
#229	MYOD1	6	12	18	1291.733
#230	ZNF496	6	10	16	557.47
#231	GABPB1	6	6	12	447.947
#232	HES6	6	10	16	479.131
#233	TP63	6	6	12	1389.656
#234	ELF3	6	6	12	311.804
#235	IKZF4	6	9	15	302.756
#236	E2F8	6	9	15	893.227
#237	CLOCK	6	8	14	2479.666
#238	MLX	6	6	12	715.721
#239	ZNF445	6	7	13	133.045
#240	ZNF639	6	14	20	2457.578
#241	IRF1	6	8	14	350.746
#242	AATF	6	11	17	2381.037
#243	SREBF2	6	14	20	2753.093
#244	GSX1	6	7	13	6463.926
#245	MYC	6	9	15	13489.254
#246	JUN	6	10	16	514.276
#247	NFKB2	6	6	12	671.495
#248	LASS5	6	13	19	11233.482
#249	HOXA1	6	12	18	2257.654
#250	TARDBP	6	10	16	2520.098
#251	MXD1	6	8	14	120.446
#252	ELK4	6	8	14	594.007
#253	CNOT7	6	10	16	1565.744
#254	ZNF367	6	9	15	1119.213
#255	UBN1	6	10	16	3274.808
#256	TFAP4	6	10	16	2075.676
#257	SP3	6	6	12	476.312
#258	TAF5L	6	7	13	738.291
#259	E2F3	6	7	13	601.592
#260	NFIX	5	12	17	603.724
#261	ZNF281	5	13	18	904.412
#262	TEAD3	5	8	13	984.636
#263	ZNF193	5	10	15	2465.658
#264	CIR1	5	10	15	7405.297
#265	ASCL1	5	5	10	8453.648
#266	SPEN	5	3	8	433.299
#267	NFXL1	5	5	10	155.932
#268	SUPT6H	5	6	11	948.666
#269	SIM2	5	9	14	2472.329
#270	PCGF6	5	12	17	3059.245
#271	ATF3	5	10	15	1188.344
#272	ZNF91	5	11	16	1736.565
#273	RELA	5	9	14	1368.511
#274	CREBL2	5	8	13	1049.116
#275	C2orf3	5	8	13	628.972
#276	RXRB	5	9	14	990.235
#277	RFXANK	5	8	13	134.897
#278	TAF13	5	6	11	376.599
#279	USF1	5	7	12	170.199
#280	HEYL	5	7	12	1141.413
#281	ZNF238	5	14	19	3055.579
#282	ZRANB2	5	8	13	1771.911
#283	PTTG1	5	5	10	204.4
#284	ZNF175	5	14	19	9644.096
#285	BHLHE40	5	7	12	1178.253
#286	PBX2	5	13	18	10095.145
#287	RCAN1	5	10	15	4940.777
#288	GTF2H3	5	8	13	344.223
#289	CBFA2T2	5	7	12	161.953
#290	TCF25	5	13	18	3279.629
#291	ZKSCAN4	5	5	10	2536.868
#292	MTA1	5	6	11	46.218
#293	SNAPC4	5	10	15	2234.128
#294	TRERF1	5	11	16	7870.72
#295	PRDM2	5	9	14	516.655
#296	PGBD1	5	9	14	320.401
#297	ZNF268	5	11	16	3153.133
#298	NKX1-1	5	12	17	4505.472
#299	FOXN2	5	11	16	1542.72
#300	KLF5	4	8	12	189.841
#301	CEBPD	4	7	11	244.896
#302	IRF6	4	12	16	334.235
#303	FOXK1	4	10	14	2078.618
#304	ZNF18	4	7	11	192.262
#305	ZXDC	4	10	14	147.877
#306	ZNF323	4	4	8	189.421
#307	ZHX1	4	6	10	602.119
#308	ZNF92	4	14	18	3970.096
#309	CREB3L4	4	11	15	1018.638
#310	NFAT5	4	9	13	512.992
#311	KLF2	4	9	13	212.158
#312	ETV3	4	8	12	329.088
#313	DRAP1	4	7	11	1432.902
#314	E2F2	4	6	10	265.347
#315	HMBOX1	4	10	14	508.96
#316	HOXB6	4	8	12	512.043
#317	BUD31	4	9	13	638.681
#318	MEF2C	4	10	14	302.05
#319	NOTCH1	4	5	9	1334.035
#320	ERF	4	9	13	1096.187
#321	HOXC10	4	10	14	1637.722
#322	FOXJ2	4	10	14	2620.045
#323	SLC2A4RG	4	11	15	526.817
#324	DBP	4	11	15	1211.244
#325	ELF4	4	6	10	141.785
#326	KDM5A	4	12	16	1297.056
#327	FOSL2	4	2	6	224.668
#328	ELK3	4	8	12	3047.73
#329	C1orf85	4	4	8	710.442
#330	RARG	4	7	11	708.32
#331	DLX1	3	14	17	2604.114
#332	HOXC9	3	6	9	1118.89
#333	GATAD2A	3	16	19	650.665
#334	XBP1	3	9	12	345.723
#335	RCOR1	3	11	14	890.132
#336	ZNF37A	3	6	9	21.365
#337	NFKB1	3	12	15	1412.113
#338	ZC3H8	3	7	10	980.318
#339	ESR1	3	12	15	373.377
#340	IRF2	3	10	13	136.239
#341	ZKSCAN2	3	13	16	303.353
#342	KLF16	3	13	16	619.984
#343	ZNF189	3	10	13	586.092
#344	E2F6	3	8	11	513.486
#345	SOX21	3	12	15	1419.768
#346	HOXD8	3	7	10	202.216
#347	PHTF1	3	13	16	943.326
#348	TFE3	3	6	9	85.36
#349	TCFL5	3	8	11	1541.111
#350	FOXJ3	3	2	5	72.84
#351	CREB3L1	3	10	13	2621.602
#352	SCML1	3	9	12	117.78
#353	ZKSCAN5	3	9	12	307.291
#354	ZNF232	3	10	13	134.268
#355	HHEX	3	12	15	2836.68
#356	ZNF215	3	10	13	555.293
#357	GTF2H4	3	11	14	4028.182
#358	TCF3	3	7	10	435.265
#359	SOX12	3	10	13	3740.999
#360	ZBTB17	3	7	10	1615.915
#361	RBCK1	3	10	13	437.266
#362	YY1	3	10	13	282.455
#363	EOMES	3	9	12	331.045
#364	ZNF263	3	11	14	6778.14
#365	ZNF449	3	8	11	212.503
#366	MNT	3	13	16	4006.213
#367	HNF4G	3	8	11	475.691
#368	ISL1	3	11	14	265.67
#369	ZFPM1	3	10	13	873.082
#370	MYOG	3	11	14	269.126
#371	PPARG	3	6	9	1099.214
#372	CDKN2A	3	13	16	1676.457
#373	HOXB5	3	9	12	556.302
#374	ZNF85	3	14	17	1454.651
#375	ZFHX3	3	10	13	1117.562
#376	ZXDA	3	8	11	80.926
#377	CSRNP2	3	8	11	82.724
#378	NCOR1	3	12	15	1758.887
#379	TSC22D3	2	5	7	875.366
#380	ZNF397	2	9	11	543.466
#381	TFAM	2	11	13	1097.939
#382	HOXA3	2	10	12	118.74
#383	RXRA	2	13	15	3556.19
#384	SMAD2	2	4	6	13.65
#385	STAT4	2	5	7	54.421
#386	SCAND1	2	10	12	1358.957
#387	MLLT10	2	9	11	943.376
#388	SMAD9	2	10	12	887.894
#389	ETV1	2	14	16	810.525
#390	ZNF202	2	7	9	118.613
#391	CREBBP	2	12	14	15792.115
#392	TCF15	2	6	8	77.841
#393	TBX3	2	11	13	263.507
#394	ZSCAN21	2	13	15	875.985
#395	PBX3	2	11	13	322.094
#396	RERE	2	11	13	298.226
#397	NR1H2	2	8	10	129.593
#398	SMAD6	2	6	8	50.498
#399	IRF8	2	8	10	104.359
#400	PPARD	2	10	12	238.169
#401	SOX15	2	7	9	360.268
#402	ZNF628	2	6	8	138.425
#403	TFCP2L1	2	13	15	314.33
#404	ZSCAN16	2	6	8	861.164
#405	IRF5	2	8	10	391.376
#406	LHX3	2	5	7	31.675
#407	TFDP3	2	12	14	610.599
#408	MAFK	2	8	10	1941.205
#409	ZNF133	2	9	11	1746.944
#410	MIXL1	2	12	14	328.123
#411	HOXA11	2	13	15	128.285
#412	SIX5	2	9	11	191.785
#413	ATF6	2	7	9	125.898
#414	ATF6B	2	6	8	208.241
#415	PHF1	2	10	12	1882.473
#416	ETS2	2	9	11	705.755
#417	ETV5	2	4	6	52.531
#418	DDIT3	1	10	11	5083.818
#419	FOXC1	1	9	10	69.248
#420	FOXP1	1	13	14	316.585
#421	TEF	1	8	9	178.575
#422	LCOR	1	8	9	100.308
#423	POU2F1	1	14	15	76.994
#424	ZSCAN2	1	10	11	42.048
#425	SMAD3	1	10	11	536.099
#426	ELK1	1	9	10	52.155
#427	CUX1	1	7	8	301.242
#428	FOXA3	1	11	12	83.934
#429	TAF1B	1	6	7	1623.352
#430	MAFG	1	8	9	17.242
#431	RFX1	1	9	10	1965.193
#432	GRHL2	1	3	4	1.033
#433	ARNT	1	16	17	37.024
#434	ZNF93	1	11	12	8214.623
#435	SP4	1	7	8	542.3
#436	ZNF274	1	3	4	1.45
#437	ZNF33B	1	5	6	142.34
#438	ZSCAN5A	1	5	6	191.888
#439	NFIC	1	12	13	35.39
#440	TEAD2	1	9	10	41.697
#441	PURA	1	6	7	16.504
#442	SATB1	1	8	9	17.289
#443	FOXP2	1	3	4	3.436
#444	RB1	1	6	7	84.787
#445	ZGPAT	1	6	7	162.126
#446	RAX	1	5	6	136.513
#447	IRX4	1	7	8	17.658
#448	ZNF187	1	10	11	84.497
#449	HOXA5	1	11	12	607.252
#450	TFDP2	1	10	11	107.623
#451	IRF9	1	9	10	16.707
#452	ARNT2	1	7	8	528.621
#453	CBL	1	9	10	7785.245
#454	GATA2	1	10	11	633.661
#455	ZNF197	1	11	12	2375.184
#456	FOXA2	1	12	13	3510.413
#457	ZHX2	1	9	10	175.821
#458	BCL3	1	9	10	252.839
#459	GCFC1	0	8	8	0
#460	TBX1	0	7	7	0
#461	HR	0	13	13	0
#462	HIRA	0	9	9	0
#463	HOXC8	0	10	10	0
#464	PAX6	0	9	9	0
#465	ETV6	0	12	12	0
#466	SOLH	0	11	11	0
#467	NFATC3	0	8	8	0
#468	FOSB	0	8	8	0
#469	ZNF19	0	7	7	0
#470	NFX1	0	9	9	0
#471	VSX1	0	7	7	0
#472	MBD1	0	12	12	0
#473	SNAPC2	0	6	6	0
#474	MTA2	0	9	9	0
#475	GLIS3	0	12	12	0
#476	HOXA13	0	12	12	0
#477	ATF5	0	10	10	0
#478	NFIA	0	6	6	0
#479	MYPOP	0	11	11	0
#480	DLX4	0	6	6	0
#481	CBFA2T3	0	9	9	0
#482	TULP4	0	10	10	0
#483	TCF19	0	4	4	0
#484	BACH2	0	6	6	0
#485	HDAC2	0	9	9	0
#486	TFEB	0	9	9	0
#487	REL	0	7	7	0
#488	FOSL1	0	14	14	0
#489	SCML2	0	13	13	0
#490	ZNF192	0	12	12	0
#491	BATF3	0	8	8	0
#492	HEY1	0	9	9	0
#493	SUPT4H1	0	6	6	0
#494	ZNF35	0	11	11	0
#495	ARNTL2	0	13	13	0
#496	MEF2D	0	10	10	0
#497	GATAD2B	0	14	14	0
#498	ZNF41	0	11	11	0
#499	HOXA2	0	10	10	0
#500	RARA	0	7	7	0