Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	PITX1	111	0	111	0
#2	GTF2IRD1	85	6	91	744.386
#3	IRF6	72	3	75	157.331
#4	ETS1	62	6	68	1039.127
#5	TFAP2C	57	6	63	234.532
#6	TRIM29	47	4	51	357.009
#7	ATF6B	45	1	46	64.546
#8	PRDM1	44	9	53	339.573
#9	ZNF207	44	8	52	2999.13
#10	GRHL3	41	5	46	3926.336
#11	FOXA3	40	10	50	3892.371
#12	ZEB2	40	5	45	213.924
#13	TAF1B	39	5	44	1480.37
#14	TBX2	38	7	45	3373.763
#15	HOPX	38	5	43	663.761
#16	NFE2L2	37	8	45	921.969
#17	ZNF274	37	6	43	549.583
#18	CITED2	34	12	46	1235.37
#19	MSL3	34	10	44	2394.08
#20	AEBP1	33	3	36	465.712
#21	ZSCAN16	33	9	42	1797.109
#22	PHTF1	33	9	42	3371.964
#23	GTF2H3	33	4	37	1343.247
#24	HEYL	32	2	34	284.885
#25	TGIF2	32	11	43	3630.441
#26	TEAD4	32	8	40	1739.495
#27	ZNF281	32	11	43	1025.154
#28	ELK1	31	8	39	2704.718
#29	CSDA	31	9	40	148.462
#30	NFIA	31	9	40	1113.458
#31	ZNF69	31	10	41	1139.275
#32	OVOL1	31	7	38	822.231
#33	HNF4G	31	11	42	1920.507
#34	LASS5	31	10	41	2205.725
#35	MAF	30	8	38	507.475
#36	HIRA	30	7	37	442.081
#37	LASS2	29	16	45	949.401
#38	RORA	29	11	40	457.323
#39	MAFB	29	8	37	156.754
#40	ZKSCAN1	29	17	46	5674.896
#41	POU3F1	28	4	32	83.147
#42	IKZF3	28	5	33	1827.949
#43	HES6	28	14	42	1523.621
#44	FOXD4L4	28	6	34	202.141
#45	RUNX1	28	15	43	1751.75
#46	E2F3	28	12	40	626.058
#47	NR1H3	27	15	42	2876.471
#48	RARA	27	17	44	12487.445
#49	CNBP	27	10	37	2264.178
#50	TADA2A	27	8	35	3862.761
#51	IRF8	27	13	40	684.102
#52	HEY1	27	9	36	2630.358
#53	HNF1A	26	5	31	560.827
#54	GATA6	26	9	35	329.304
#55	NOLC1	26	6	32	1567.056
#56	CBFB	26	17	43	2559.674
#57	TSC22D2	26	10	36	1580.437
#58	HES1	26	9	35	1682.539
#59	SP4	26	16	42	4323.803
#60	RFX5	26	16	42	1744.243
#61	YEATS4	25	6	31	1416.495
#62	AFF4	25	11	36	2687.731
#63	ZSCAN2	25	11	36	2961.406
#64	FOXA2	25	10	35	252.643
#65	ZNF323	25	8	33	1177.775
#66	LHX2	24	4	28	388.34
#67	TFDP1	24	12	36	1567.08
#68	SREBF1	24	13	37	1746.349
#69	SOX4	24	18	42	1826.057
#70	TCF4	24	4	28	334.89
#71	MEF2C	24	8	32	1667.716
#72	ADNP	24	13	37	2103.935
#73	RFX3	23	5	28	1229.476
#74	ATF1	23	5	28	289.988
#75	NFIX	23	12	35	4048.334
#76	FOXD2	23	10	33	1024.754
#77	TAF4	23	15	38	2088.532
#78	MTF1	23	11	34	5043.155
#79	GABPB1	22	11	33	2811.622
#80	CNOT8	22	10	32	748.184
#81	ZNF133	22	9	31	1487.265
#82	ECSIT	22	12	34	1489.548
#83	BCL6	22	17	39	2663.253
#84	RAX2	22	10	32	957.379
#85	IRX1	22	3	25	1047.792
#86	POU2F1	22	10	32	2278.609
#87	ALX3	22	6	28	380.038
#88	TCF7L2	22	10	32	1214.113
#89	HOXB5	22	12	34	1036.962
#90	SOX15	22	5	27	333.059
#91	ZHX1	22	6	28	1837.727
#92	PPARG	22	13	35	1589.817
#93	SOX7	22	8	30	171.831
#94	SCAND1	21	14	35	2631.273
#95	HOMEZ	21	9	30	3567.365
#96	SCML2	21	7	28	1384.225
#97	ZNF268	21	14	35	2243.878
#98	GCFC1	21	12	33	2100.015
#99	FLI1	21	5	26	82.406
#100	ESRRA	21	14	35	2489.515
#101	TSHZ3	21	8	29	321.256
#102	E4F1	21	10	31	655.797
#103	FOXQ1	21	13	34	623.962
#104	MEIS1	21	8	29	716.389
#105	THRB	21	4	25	964.623
#106	RELB	21	12	33	2515.433
#107	NR2F6	21	19	40	4182.803
#108	LHX6	21	10	31	2294.552
#109	ZBTB48	20	15	35	2433.926
#110	E2F6	20	9	29	2719.368
#111	STRN3	20	15	35	3260.735
#112	AATF	20	16	36	2526.596
#113	FOXD4L5	20	1	21	34.597
#114	GAS7	20	9	29	153.065
#115	TCF3	20	15	35	1254.64
#116	GABPA	19	7	26	1930.654
#117	BLZF1	19	7	26	1721.438
#118	KLF11	19	12	31	1377.098
#119	IRF3	19	17	36	1948.489
#120	TAF13	19	14	33	2936.273
#121	KLF17	19	9	28	453.667
#122	HDAC2	19	12	31	1391.85
#123	KLF2	19	9	28	567.606
#124	HNF1B	19	10	29	895.543
#125	TSHZ1	19	9	28	3922.302
#126	MTA2	19	13	32	6257.32
#127	SIX4	18	15	33	2780.417
#128	DMRT1	18	8	26	567.912
#129	TEAD2	18	9	27	437.929
#130	HOXA13	18	10	28	2210.627
#131	C11orf9	18	8	26	499.524
#132	MEIS2	18	18	36	5661.241
#133	POU2F2	18	10	28	423.994
#134	GLIS3	18	6	24	98.464
#135	ZFPM1	18	14	32	2512.179
#136	ONECUT2	18	13	31	1292.667
#137	ZNF33B	18	9	27	3564.516
#138	SCML1	18	16	34	4089.449
#139	ZNF35	17	11	28	662.795
#140	CNOT7	17	16	33	3959.402
#141	FOXO4	17	11	28	2562.584
#142	TCFL5	17	7	24	1569.384
#143	SIN3A	17	11	28	1555.845
#144	JDP2	17	5	22	225.969
#145	ZRANB2	17	10	27	2545.759
#146	MAX	17	14	31	1787.179
#147	RBPJ	17	14	31	1415.097
#148	FOXS1	17	6	23	313.015
#149	ZNF189	17	13	30	2957.509
#150	ZNF193	16	14	30	2838.141
#151	HOXB7	16	16	32	370.466
#152	HOXA10	16	15	31	682.587
#153	CLOCK	16	16	32	984.173
#154	FOXF1	16	9	25	350.911
#155	NFE2L3	16	16	32	2195.74
#156	EPAS1	16	15	31	8030.775
#157	FOXJ3	16	16	32	1252.961
#158	NR3C2	16	10	26	1036.302
#159	ZNF277	16	14	30	918.76
#160	PURA	16	10	26	2091.477
#161	ZNF444	16	9	25	1472.374
#162	ARID4A	16	10	26	1611.758
#163	TFCP2	16	14	30	843.193
#164	FOXP1	16	14	30	630.564
#165	PHF5A	16	13	29	951.266
#166	CSRNP2	16	11	27	2429.907
#167	FOXM1	16	7	23	583.61
#168	AHCTF1	16	12	28	866.909
#169	RXRB	16	8	24	1209.733
#170	TADA3	16	14	30	1480.478
#171	PPARD	15	10	25	435.185
#172	ERG	15	4	19	410.253
#173	SMAD6	15	17	32	856.845
#174	PBX1	15	13	28	2065.832
#175	TP63	15	12	27	2014.875
#176	CREBBP	14	11	25	1418.681
#177	NFATC3	14	9	23	1006.984
#178	NPAS1	14	9	23	461.176
#179	ETV5	14	12	26	401.447
#180	EHF	14	13	27	2115.921
#181	MNX1	14	15	29	2243.702
#182	BATF3	14	13	27	1402.465
#183	TAF7	14	11	25	657.494
#184	SCMH1	14	9	23	1314.674
#185	KLF9	14	18	32	3362.875
#186	CEBPB	14	14	28	1367.351
#187	DMTF1	14	12	26	867.939
#188	LZTR1	14	15	29	2145.002
#189	CDX2	14	15	29	1055.002
#190	E2F7	14	12	26	829.865
#191	ATF6	14	11	25	1265.645
#192	KDM5B	13	14	27	1642.745
#193	FOXN2	13	21	34	2328.957
#194	MLLT10	13	11	24	1459.243
#195	STAT5B	13	12	25	423.454
#196	NFE2L1	13	19	32	2361.325
#197	NR3C1	13	13	26	761.443
#198	SOLH	13	13	26	1333.417
#199	RORC	13	10	23	1217.155
#200	ZNF18	13	15	28	1486.466
#201	BHLHE40	13	16	29	2658.379
#202	RXRA	13	10	23	681.449
#203	NR1H2	13	13	26	1439.796
#204	EBF1	13	13	26	997.809
#205	SIX5	13	18	31	2669.876
#206	BNC1	13	7	20	2488.246
#207	ZSCAN5A	12	8	20	742.085
#208	LHX1	12	7	19	302.043
#209	FOXF2	12	12	24	745.362
#210	SOX30	12	4	16	811.887
#211	MLXIPL	12	14	26	3319.396
#212	LMO4	12	13	25	2639.827
#213	MEF2D	12	20	32	2683.574
#214	PGBD1	12	13	25	1286.546
#215	CREB3L4	12	15	27	2004.571
#216	REXO4	12	11	23	1480.715
#217	SPEN	12	11	23	1173.736
#218	TFAP2A	12	15	27	2249.103
#219	PCGF2	12	14	26	1790.164
#220	IRX3	12	17	29	3391.933
#221	RFXANK	12	6	18	778.785
#222	RFX1	12	15	27	1797.918
#223	STAT3	12	12	24	1368.617
#224	CUX1	12	6	18	68.192
#225	BATF2	11	11	22	2943.38
#226	HOXC4	11	16	27	1562.13
#227	ZNF394	11	19	30	1459.596
#228	FOSB	11	2	13	73.251
#229	MITF	11	14	25	2710.306
#230	RB1	11	9	20	837.821
#231	NFIB	11	8	19	140.656
#232	HOXC13	11	10	21	638.917
#233	ENO1	11	14	25	1162.627
#234	ISL1	11	18	29	572.801
#235	KLF6	11	11	22	1716.088
#236	LEF1	11	13	24	4332.564
#237	XBP1	11	14	25	724.77
#238	TAF10	11	11	22	875.123
#239	TFCP2L1	11	15	26	1292.766
#240	CTCF	11	17	28	2537.339
#241	ETV3	11	17	28	1497.086
#242	ZC3H8	11	10	21	699.749
#243	PRRX1	11	8	19	81.049
#244	JUN	11	7	18	834.403
#245	BATF	11	13	24	633.411
#246	NFX1	11	14	25	584.587
#247	MECOM	11	12	23	1351.197
#248	BCL11B	11	12	23	726.582
#249	E2F5	11	18	29	3768.085
#250	CCRN4L	11	12	23	1549.67
#251	NFKB2	11	10	21	711.038
#252	ATF5	11	19	30	1624.177
#253	ETV6	10	19	29	2120.862
#254	MXD1	10	23	33	3275.784
#255	NPAS2	10	17	27	2067.46
#256	TCF21	10	11	21	1527.954
#257	PTTG1	10	10	20	510.068
#258	HOXA4	10	13	23	830.048
#259	ZFP42	10	12	22	623.16
#260	TBP	10	16	26	938.879
#261	E2F4	10	18	28	932.555
#262	ETS2	10	21	31	6456.801
#263	USF2	10	12	22	4539.705
#264	SP1	10	18	28	1141.19
#265	ZNF165	10	10	20	662.897
#266	NOTCH1	9	20	29	755.38
#267	UHRF1	9	23	32	1523.169
#268	NFE2	9	13	22	853.92
#269	LZTS1	9	17	26	1319.504
#270	NFIL3	9	12	21	1491.018
#271	POU5F1	9	24	33	3480.954
#272	SIM2	9	17	26	503.745
#273	ELF1	9	15	24	761.454
#274	E2F1	9	22	31	1460.162
#275	STAT1	9	11	20	908.176
#276	CUX2	9	12	21	998.933
#277	WNT5A	9	12	21	344.078
#278	SOX18	9	11	20	72.129
#279	GATAD2B	9	14	23	1539.139
#280	EGR2	9	7	16	242.343
#281	HMX2	9	15	24	2894.355
#282	NFXL1	9	16	25	2319.107
#283	CREM	9	11	20	288.027
#284	SLC2A4RG	9	10	19	383.541
#285	TARDBP	9	16	25	1535.826
#286	HNRNPAB	8	20	28	1302.604
#287	MYNN	8	17	25	2043.804
#288	HOXB8	8	14	22	1516.353
#289	AHR	8	14	22	668.281
#290	NR2C1	8	22	30	2144.095
#291	VSX1	8	9	17	1262.863
#292	EGR1	8	12	20	1663.682
#293	PROX1	8	10	18	566.231
#294	TRIM28	8	17	25	948.049
#295	FOXA1	8	20	28	1164.186
#296	ZSCAN21	8	14	22	1397.694
#297	HOXA6	8	9	17	261.534
#298	BHLHE41	8	17	25	949.182
#299	FOSL2	8	14	22	713.252
#300	MSX2	8	13	21	1107.447
#301	PLAGL2	8	14	22	5090.716
#302	EOMES	8	11	19	657.218
#303	HES5	8	10	18	94.206
#304	HCLS1	8	9	17	409.041
#305	TULP4	8	10	18	447.378
#306	HIF1A	8	11	19	575.982
#307	IRX4	8	6	14	62.76
#308	TRPS1	8	10	18	302.402
#309	RCAN1	8	19	27	1968.352
#310	IRX5	8	18	26	2187.236
#311	TRERF1	8	19	27	450.676
#312	TCEAL1	8	21	29	357.98
#313	SNAI2	7	10	17	674.319
#314	ZNF438	7	15	22	672.644
#315	SMAD5	7	18	25	620.472
#316	TBX3	7	18	25	525.223
#317	HOXA2	7	15	22	770.892
#318	ZSCAN18	7	18	25	1862.028
#319	KLF4	7	27	34	1692.591
#320	NR4A3	7	11	18	491.403
#321	GATAD2A	7	17	24	1040.711
#322	UBN1	7	16	23	335.98
#323	FOS	7	6	13	156.204
#324	FOXO1	7	15	22	1345.133
#325	ZNF167	7	11	18	1346.707
#326	CREB1	7	14	21	1424.544
#327	NPAT	7	23	30	1451.339
#328	DRAP1	7	12	19	306.031
#329	VENTX	7	7	14	437.884
#330	NFIC	7	12	19	229.057
#331	FOXE1	7	11	18	4895.707
#332	NR4A2	7	14	21	736.037
#333	GTF2I	7	8	15	501.408
#334	RBCK1	7	12	19	3573.453
#335	NEUROD2	7	15	22	725.118
#336	DDIT3	7	24	31	802.501
#337	ELF4	6	17	23	924.237
#338	ZIC2	6	25	31	2555.772
#339	THRA	6	20	26	4144.31
#340	BTAF1	6	16	22	477.165
#341	GATA4	6	12	18	761.676
#342	SMAD9	6	9	15	561.634
#343	KLF5	6	21	27	1358.566
#344	ZNF213	6	15	21	3572.758
#345	PLSCR1	6	23	29	2369.144
#346	FOXI2	6	10	16	68.761
#347	ERF	6	14	20	822.367
#348	HOXD3	6	5	11	14.853
#349	BCL3	6	17	23	2349.472
#350	HOXC9	6	15	21	1167.304
#351	ATF3	6	11	17	661.195
#352	SPI1	6	13	19	996.383
#353	NR5A2	6	11	17	473.307
#354	CEBPA	5	15	20	2462.623
#355	REL	5	16	21	764.022
#356	MYC	5	15	20	2347.625
#357	ZFP90	5	14	19	442.635
#358	RERE	5	16	21	1974.701
#359	TEAD3	5	14	19	450.705
#360	PBX2	5	14	19	1162.976
#361	ZNF134	5	15	20	1676.74
#362	ARID3A	5	17	22	588.75
#363	SATB2	5	15	20	1111.356
#364	HOXC8	5	18	23	522.233
#365	ETV4	5	18	23	753.55
#366	ZFP36L1	5	20	25	1384.136
#367	HLF	5	13	18	599.396
#368	MSX1	5	16	21	922.472
#369	USF1	5	16	21	1070.974
#370	HOXB9	5	15	20	565.965
#371	E2F8	5	11	16	875.417
#372	PBX4	5	14	19	289.101
#373	ZSCAN4	5	12	17	1306.171
#374	IRX2	5	20	25	9761.019
#375	TFAP2B	5	8	13	156.044
#376	TBX10	5	16	21	4467.263
#377	SNAPC4	5	14	19	331.436
#378	DLX3	5	9	14	57.332
#379	HMGB2	5	13	18	621.45
#380	HOXA5	4	18	22	322.375
#381	SMAD4	4	17	21	852.927
#382	ZNF256	4	14	18	810.391
#383	CSRNP1	4	15	19	2814.945
#384	TWIST1	4	10	14	135.845
#385	TMEM229A	4	18	22	829.805
#386	GATAD1	4	15	19	342.824
#387	TAF4B	4	20	24	2113.258
#388	KLF12	4	13	17	242.542
#389	DBP	4	12	16	470.483
#390	STAT5A	4	15	19	392.578
#391	PFDN1	4	12	16	812.739
#392	FOXC1	4	17	21	444.086
#393	RARB	4	13	17	484.456
#394	MEOX1	4	15	19	112.393
#395	PRRX2	4	21	25	250.824
#396	ELF3	4	17	21	960.863
#397	TEF	4	19	23	1797.574
#398	ZNF140	4	16	20	432.376
#399	MNT	4	20	24	2949.455
#400	GRHL2	4	16	20	688.674
#401	SOX21	4	29	33	1149.503
#402	TSC22D3	4	25	29	2453.332
#403	SUPT4H1	4	17	21	449.461
#404	UBP1	4	12	16	756.189
#405	TFAM	4	8	12	149.098
#406	PLAG1	4	20	24	4033.032
#407	IRF9	4	11	15	433.022
#408	TCF25	4	12	16	322.02
#409	ZNF219	3	14	17	83.421
#410	FOXJ1	3	22	25	688.726
#411	TSC22D1	3	27	30	823.138
#412	MZF1	3	14	17	105.199
#413	HOXC6	3	17	20	301.392
#414	TCF12	3	20	23	997.58
#415	STAT4	3	17	20	249.301
#416	ARNTL	3	16	19	1281.742
#417	ESRRG	3	16	19	172.085
#418	PURB	3	18	21	834.358
#419	ELF5	3	12	15	299.114
#420	RUNX3	3	19	22	801.217
#421	SLC26A3	3	16	19	199.768
#422	GLI2	3	17	20	2145.327
#423	HOXA3	3	13	16	1801.602
#424	CTNNB1	3	13	16	495.351
#425	ASCL2	3	23	26	3389.597
#426	SOX11	3	9	12	110.396
#427	C1orf85	3	17	20	262.927
#428	HSF2	3	18	21	191.6
#429	JUND	3	12	15	183.232
#430	EDF1	3	15	18	179.352
#431	ZNF217	3	19	22	1086.848
#432	FBXW7	3	11	14	88.441
#433	NKX2-3	3	4	7	98.103
#434	HOXB6	3	17	20	703.06
#435	TSHZ2	3	16	19	125.554
#436	ZFP37	3	11	14	238.911
#437	SREBF2	3	14	17	676.957
#438	CREB3L2	3	12	15	764.821
#439	SMAD3	3	20	23	2166.286
#440	LASS6	3	17	20	218.061
#441	IRF7	2	19	21	185.998
#442	HHEX	2	14	16	38.534
#443	E2F2	2	20	22	151.01
#444	ZFHX4	2	13	15	473.67
#445	FOSL1	2	19	21	954.463
#446	ZFHX3	2	16	18	111.389
#447	MSRB2	2	20	22	1352.879
#448	GATA5	2	15	17	50.195
#449	NR2F1	2	13	15	60.46
#450	AR	2	14	16	1437.771
#451	ARNT2	2	15	17	126.278
#452	ZNF187	2	16	18	816.414
#453	GLI3	2	16	18	1956.002
#454	ISX	2	12	14	596.466
#455	BTG2	2	13	15	674.264
#456	STAT2	2	16	18	1354.142
#457	FOXD1	2	14	16	824.245
#458	MESP1	2	19	21	780.732
#459	MYT1	2	11	13	652.721
#460	ARNT	2	16	18	1020.031
#461	ZNF175	2	12	14	70.665
#462	TRIM22	2	17	19	166.352
#463	PBX3	2	20	22	1434.096
#464	SOX9	2	20	22	85.972
#465	PA2G4	2	15	17	2055.495
#466	IRF1	2	18	20	534.23
#467	NFATC1	2	20	22	611.256
#468	CREB5	2	20	22	431.327
#469	MTA1	1	19	20	337.802
#470	CDKN2A	1	17	18	52.103
#471	LHX4	1	12	13	14.462
#472	SOX8	1	15	16	170.788
#473	FOXC2	1	13	14	642.028
#474	SRF	1	16	17	187.482
#475	BARX1	1	16	17	263.936
#476	MKX	1	17	18	131.671
#477	ZNF83	1	19	20	75.687
#478	TSC22D4	1	14	15	32.077
#479	CBFA2T2	1	21	22	176.85
#480	IRX6	1	11	12	237.846
#481	ZNF91	1	22	23	196.496
#482	HOXB4	1	12	13	33.166
#483	PEG3	1	15	16	94.809
#484	NR1D2	1	15	16	128.903
#485	CEBPD	1	12	13	38.403
#486	NME2	0	18	18	0
#487	HOXA9	0	16	16	0
#488	HMBOX1	0	10	10	0
#489	STAT6	0	9	9	0
#490	RUNX2	0	21	21	0
#491	CREB3L3	0	15	15	0
#492	MEOX2	0	15	15	0
#493	NKX6-2	0	18	18	0
#494	TGIF1	0	19	19	0
#495	PAX8	0	17	17	0
#496	HOXB2	0	20	20	0
#497	NKX3-1	0	20	20	0
#498	IRF4	0	13	13	0
#499	PRDM2	0	12	12	0
#500	ASCL1	0	9	9	0