Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	FOXA1	141	0	141	0
#2	ELK3	108	7	115	1189.354
#3	CREB3L4	96	7	103	382.145
#4	FOSL1	96	7	103	494.192
#5	IRF6	87	8	95	4028.733
#6	HMGA2	87	4	91	442.83
#7	ZNF238	77	16	93	1607.503
#8	CEBPA	72	10	82	314.676
#9	RXRA	68	13	81	2357.682
#10	GATA3	67	13	80	1204.451
#11	TBX2	66	6	72	427.356
#12	ETS1	62	5	67	62.437
#13	ASCL2	62	10	72	1137.507
#14	TRPS1	62	7	69	69.904
#15	NFE2L3	61	16	77	1467.391
#16	IRX5	60	7	67	151.882
#17	E2F7	58	12	70	3284.419
#18	ZNF217	57	12	69	1997.371
#19	TFAP2C	56	12	68	511.607
#20	SPDEF	56	8	64	169.353
#21	NR3C1	55	8	63	4488.535
#22	XBP1	55	3	58	556.749
#23	TFAP2A	54	13	67	1222.494
#24	NFATC3	54	9	63	2449.078
#25	MSX2	53	13	66	514.322
#26	ETS2	52	17	69	1789.917
#27	E2F6	50	10	60	399.321
#28	FOXF2	50	8	58	146.639
#29	TCF25	49	5	54	93.663
#30	GABPB1	49	14	63	1580.007
#31	RCAN1	49	12	61	596.567
#32	TSC22D3	48	15	63	1393.332
#33	ZEB1	48	5	53	142.729
#34	SUPT4H1	47	11	58	542.568
#35	ZNF117	44	13	57	741.352
#36	VDR	43	11	54	414.755
#37	ETV4	43	11	54	846.827
#38	IRX2	43	16	59	1447.904
#39	PBX1	42	12	54	863.228
#40	HOXC10	40	11	51	1747.779
#41	ZNF91	39	17	56	4789.742
#42	ESR1	39	9	48	803.324
#43	PGBD1	39	17	56	2725.322
#44	HOXA3	38	8	46	958.084
#45	SMAD1	37	10	47	905.898
#46	RUNX2	37	17	54	1718.491
#47	BACH1	37	17	54	563.184
#48	CUX1	36	13	49	1130.45
#49	ETV1	36	10	46	1426.529
#50	TFCP2	36	19	55	2795.567
#51	MEIS2	35	21	56	5562.634
#52	GRHL2	35	9	44	226.671
#53	ZNF71	34	14	48	2886.432
#54	TBX3	34	18	52	2797.27
#55	MECOM	33	27	60	5177.721
#56	NFIA	32	11	43	1832.796
#57	TWIST2	32	10	42	650.791
#58	MEIS1	30	16	46	1021.464
#59	PHF1	30	13	43	356.924
#60	NR2F2	30	23	53	6234.464
#61	MSRB2	30	17	47	2916.967
#62	HOXA7	30	9	39	712.134
#63	RBPJ	29	13	42	788.93
#64	PLSCR1	29	14	43	2291.977
#65	ARNTL2	29	13	42	159.42
#66	SNAI2	29	9	38	269.579
#67	HOXA9	29	9	38	596.763
#68	ZHX2	29	19	48	1203.883
#69	PAX6	28	9	37	844.606
#70	ZEB2	28	8	36	785.49
#71	ZNF3	28	14	42	2551.496
#72	ELF3	28	14	42	367.823
#73	TFDP1	28	23	51	3910.712
#74	SATB2	28	19	47	988.725
#75	HOXA10	28	15	43	6220.371
#76	ELF4	28	17	45	736.101
#77	PHTF1	28	15	43	719.707
#78	ZBTB38	28	16	44	947.417
#79	HOXA1	27	7	34	199.042
#80	NFIX	27	20	47	1660.773
#81	NFIB	27	17	44	1638.634
#82	HOXB7	27	19	46	1134.708
#83	ZNF138	27	17	44	1023.133
#84	DLX6	27	7	34	721.018
#85	IRF1	27	15	42	464.549
#86	FOXQ1	26	10	36	533.199
#87	CBFA2T3	26	8	34	362.848
#88	KDM5B	26	18	44	505.213
#89	CDKN2A	26	19	45	2124.085
#90	GATAD2B	25	11	36	204.662
#91	FOXD1	25	20	45	1931.544
#92	MAFB	25	15	40	443.253
#93	HOXA2	25	12	37	1609.02
#94	ZNF175	25	18	43	1601.709
#95	LASS6	25	23	48	1915.726
#96	TEAD1	25	14	39	2204.509
#97	HOXC13	25	18	43	726.006
#98	ZNF85	24	17	41	704.518
#99	LMO4	24	16	40	685.879
#100	FOXO6	24	19	43	2031.673
#101	HOXC9	23	14	37	3209.88
#102	HES1	23	11	34	285.912
#103	CREB3L1	23	17	40	1415.317
#104	ZNF75D	23	16	39	361.629
#105	EGR3	23	6	29	497.966
#106	RARA	22	16	38	309.196
#107	TRERF1	22	19	41	1369.552
#108	PPARG	22	15	37	4089.932
#109	EN1	22	8	30	529.027
#110	ETV5	22	16	38	320.657
#111	EHF	22	19	41	932.627
#112	HOXB6	22	7	29	1028.069
#113	SIX2	22	16	38	6344.767
#114	NR2F6	22	17	39	819.295
#115	SOX13	21	15	36	305.467
#116	TEAD4	21	13	34	1375.865
#117	NPAS2	21	18	39	840.736
#118	PTTG1	21	16	37	1259.384
#119	HES6	21	21	42	905.701
#120	TSC22D1	21	21	42	1243.811
#121	TCEAL1	21	22	43	3448.772
#122	SIX1	21	26	47	4930.854
#123	CEBPD	21	26	47	2022.062
#124	SMAD4	21	19	40	4236.446
#125	CSDA	21	23	44	4878.401
#126	KLF5	21	20	41	4487.838
#127	TCFL5	21	19	40	1498.854
#128	MLLT10	20	17	37	703.901
#129	TAF12	20	9	29	168.602
#130	E2F5	20	27	47	5549.788
#131	ONECUT2	20	19	39	1043.769
#132	MNX1	20	16	36	709.106
#133	AR	20	19	39	1136.502
#134	SOX4	20	14	34	642.725
#135	NFE2L1	20	21	41	5125.742
#136	THRB	20	16	36	1638.657
#137	ATF6	19	14	33	741.071
#138	MSX1	19	17	36	2289.716
#139	AHR	19	24	43	1322.792
#140	OVOL1	19	12	31	137.516
#141	PITX1	19	25	44	4525.176
#142	CEBPB	19	20	39	1346.64
#143	PBX3	19	18	37	913.992
#144	HOXC11	19	14	33	644.211
#145	PRDM1	19	10	29	1169.193
#146	ZFP90	19	14	33	4266.215
#147	SOX7	19	10	29	1308.963
#148	HOXA11	19	4	23	238.147
#149	TGIF2	19	19	38	2478.431
#150	ZKSCAN1	19	15	34	387.208
#151	HOXB5	19	7	26	609.14
#152	ZNF434	18	11	29	164.964
#153	WNT5A	18	19	37	1541.796
#154	EPAS1	18	21	39	2685.94
#155	NKX3-1	18	23	41	4707.376
#156	ZIC2	18	27	45	2701.529
#157	HHEX	18	15	33	402.155
#158	GATA6	18	21	39	1722.983
#159	FOXP1	18	15	33	1447.704
#160	MEIS3P1	18	22	40	1993.038
#161	MYBL2	18	13	31	965.616
#162	HEY1	18	17	35	3718.308
#163	TSHZ1	18	20	38	763.752
#164	MEF2A	18	16	34	546.594
#165	TCF12	18	16	34	2631.022
#166	ZFPM1	18	12	30	378.251
#167	TSC22D2	18	19	37	1857.903
#168	GLI3	17	18	35	1126.621
#169	IRX4	17	16	33	3544.94
#170	FOSL2	17	21	38	1740.592
#171	HEY2	17	16	33	452.576
#172	TCF19	17	6	23	556.305
#173	SOX2	17	21	38	978.189
#174	TCF4	17	14	31	1154.649
#175	CNOT7	17	18	35	495.197
#176	SIX4	17	17	34	1675.287
#177	ZNF232	17	18	35	1340.847
#178	ARID3A	17	20	37	1780.03
#179	SOX11	17	20	37	2278.627
#180	PGR	17	14	31	304.524
#181	MMP14	17	14	31	353.67
#182	HOXB2	17	12	29	957.305
#183	ZNF92	16	18	34	862.603
#184	HINFP	16	18	34	1026.28
#185	JUNB	16	18	34	698.155
#186	MAFF	16	23	39	580.336
#187	HOXA5	16	13	29	581.771
#188	CREM	16	23	39	1413.276
#189	RELB	16	14	30	851.047
#190	DBP	16	17	33	343.038
#191	TFCP2L1	16	12	28	1304.277
#192	EBF1	16	11	27	1084.621
#193	ZNF134	16	24	40	1586.448
#194	ZNF274	16	15	31	2268.622
#195	KLF9	16	27	43	668.084
#196	C12orf28	16	17	33	2039.609
#197	MSC	15	10	25	406.661
#198	NFIL3	15	24	39	1115.178
#199	BCL6	15	17	32	798.166
#200	TAF1B	15	16	31	1300.017
#201	RUNX3	15	15	30	1548.124
#202	ZIC1	15	26	41	1520.124
#203	NOTCH1	15	26	41	2425.719
#204	SP4	15	18	33	1962.559
#205	UHRF1	15	12	27	1266.613
#206	ZNF93	15	17	32	1296.307
#207	SOX9	15	27	42	2711.818
#208	TAF4B	15	20	35	1739.738
#209	ZNF174	15	16	31	703.456
#210	STAT6	15	25	40	835.466
#211	MSL3	14	13	27	1712.955
#212	C2orf3	14	22	36	1538.438
#213	TEAD2	14	30	44	2598.651
#214	PROX1	14	7	21	891.097
#215	FOXK2	14	17	31	1226.714
#216	TULP4	14	12	26	368.266
#217	STAT5B	14	19	33	1311.291
#218	MGA	14	16	30	665.355
#219	TRIM22	14	19	33	1174.827
#220	HMGA1	13	18	31	135.666
#221	POU2F1	13	16	29	245.777
#222	TGIF1	13	19	32	1180.51
#223	POU4F1	13	10	23	265.611
#224	SIM2	13	20	33	1218.194
#225	CTBP1	13	21	34	1960.37
#226	ZNF277	13	12	25	313.985
#227	SALL2	13	28	41	2532.497
#228	IRX3	13	14	27	398.876
#229	ZNF131	13	16	29	657.385
#230	PRRX1	13	6	19	178.555
#231	BATF	13	16	29	218.507
#232	E2F8	13	19	32	1756.016
#233	RORA	13	20	33	2836.881
#234	NR4A2	13	20	33	905.977
#235	SMAD6	13	23	36	1716.601
#236	TWIST1	13	26	39	1886.637
#237	SCML1	13	13	26	2803.997
#238	SLC2A4RG	13	22	35	663.135
#239	GLIS2	13	22	35	936.124
#240	ZSCAN5A	13	17	30	674.388
#241	ZFP36L1	13	24	37	1604.665
#242	SMAD3	13	19	32	409.193
#243	TRIM29	12	26	38	2142.23
#244	AFF4	12	14	26	805.072
#245	KLF4	12	22	34	1376.592
#246	KLF12	12	21	33	742.225
#247	HOXB13	12	11	23	1256.711
#248	ETV6	12	17	29	438.955
#249	IRF9	12	24	36	2018.145
#250	GLIS3	12	11	23	1054.799
#251	SATB1	12	29	41	2115.005
#252	ZHX1	12	18	30	1700.06
#253	JUN	12	20	32	1450.878
#254	ZNF207	12	19	31	458.317
#255	PCGF2	12	26	38	3556.444
#256	GATA2	12	20	32	874.066
#257	RARG	12	15	27	324.729
#258	ESRRG	12	19	31	1745.229
#259	TEF	11	16	27	839.185
#260	BCL3	11	17	28	473.942
#261	KDM5A	11	17	28	420.983
#262	PITX2	11	19	30	865.664
#263	CSRNP2	11	19	30	249.821
#264	C1orf85	11	24	35	772.121
#265	FOXO3	11	20	31	1121.22
#266	FOXC2	11	17	28	1043.405
#267	ELF1	11	21	32	483.196
#268	FOXO1	11	16	27	495.822
#269	BTG2	11	21	32	414.344
#270	ZHX3	11	17	28	1152.858
#271	BHLHE41	11	19	30	1873.126
#272	GATAD1	11	19	30	1032.802
#273	PLAG1	11	12	23	1365.196
#274	MBD1	11	25	36	2210.116
#275	ISL1	11	12	23	1426.286
#276	FOXJ3	11	21	32	1277.53
#277	HNF4G	11	12	23	690.6
#278	E2F1	11	18	29	942.813
#279	FOXM1	11	10	21	575.833
#280	PEG3	11	22	33	3246.891
#281	ZNF45	11	23	34	1416.9
#282	CTNNB1	10	22	32	2397.179
#283	HSF1	10	16	26	1417.926
#284	HOXC4	10	16	26	451.345
#285	MYC	10	22	32	1607.726
#286	ZFP37	10	22	32	3846.015
#287	TAF5	10	17	27	552.173
#288	E2F2	10	22	32	1156.605
#289	THRA	10	22	32	1503.758
#290	SIM1	10	10	20	451.395
#291	PPARA	10	17	27	111.202
#292	ZSCAN18	10	23	33	1714.086
#293	STRN3	10	8	18	78.205
#294	ZNF135	10	12	22	1124.81
#295	FBXW7	10	18	28	2248.977
#296	ZSCAN2	10	14	24	670.424
#297	TP63	10	9	19	568.677
#298	JDP2	10	22	32	960.208
#299	POU3F2	10	15	25	704.093
#300	ZFHX3	10	18	28	305.909
#301	HOXB4	10	12	22	672.02
#302	RFXAP	10	22	32	1855.9
#303	STAT3	10	21	31	1028.876
#304	ZNF367	10	14	24	1069.084
#305	MESP1	10	19	29	1953.178
#306	HR	10	19	29	634.709
#307	LZTS1	10	11	21	609.116
#308	ISL2	10	8	18	365.756
#309	CREBZF	9	18	27	623.019
#310	ARID4A	9	24	33	543.645
#311	HOXB8	9	5	14	481.161
#312	HOPX	9	16	25	1962.299
#313	SIN3A	9	16	25	495.245
#314	MEF2C	9	13	22	455.067
#315	ANKRD30A	9	13	22	466.38
#316	GATA4	9	13	22	811.697
#317	FOXA3	9	13	22	490.111
#318	REL	9	23	32	643.769
#319	HOXB3	9	18	27	1264.785
#320	FOXC1	9	16	25	604.316
#321	STAT1	9	19	28	669.272
#322	PRRX2	9	20	29	1815.167
#323	AHCTF1	9	22	31	645.079
#324	ZNF496	9	22	31	2618.546
#325	CITED1	9	20	29	1593.378
#326	MTA3	9	21	30	1115.734
#327	BATF3	9	11	20	44.76
#328	FOS	9	21	30	317.841
#329	MAFG	9	13	22	182.699
#330	RUNX1	9	19	28	3075.075
#331	CREB5	9	14	23	827.659
#332	TP53	9	18	27	1207.115
#333	CBFB	8	20	28	1477.086
#334	ZNF83	8	20	28	1385.473
#335	LEF1	8	20	28	1571.953
#336	C5orf41	8	14	22	210.169
#337	SMAD2	8	20	28	2246.301
#338	ZNF213	8	16	24	271.544
#339	PURA	8	21	29	981.046
#340	CREB3L2	8	24	32	4715.562
#341	NR2F1	8	26	34	1057.474
#342	ZNF397	8	17	25	702.249
#343	SREBF1	8	24	32	664.322
#344	MAF	8	15	23	1143.688
#345	CBFA2T2	8	17	25	345.8
#346	SCMH1	8	23	31	497.318
#347	ATF7	8	21	29	319.679
#348	NKX2-5	8	18	26	756.451
#349	PAX3	8	9	17	1066.575
#350	TBX1	8	15	23	1366.045
#351	ZNF165	8	16	24	225.336
#352	DLX1	8	24	32	1484.635
#353	ARNT2	8	20	28	576.95
#354	SLC30A9	7	24	31	973.567
#355	POU2F3	7	20	27	856.694
#356	EGR1	7	27	34	716.26
#357	HMBOX1	7	24	31	576.859
#358	DLX3	7	15	22	645.135
#359	FOXG1	7	18	25	514.897
#360	MYCN	7	24	31	629.703
#361	ENO1	7	12	19	117.012
#362	TFAP2B	7	14	21	306.141
#363	L3MBTL4	7	8	15	781.492
#364	LHX2	7	24	31	350.324
#365	NFE2L2	7	18	25	769.821
#366	C11orf9	7	11	18	234.273
#367	ZSCAN16	7	18	25	243.118
#368	GATA5	7	8	15	343.516
#369	VAV1	7	18	25	941.793
#370	SOX8	6	11	17	302.242
#371	ZFP42	6	9	15	148.747
#372	KLF6	6	21	27	163.293
#373	BHLHE40	6	26	32	2396.896
#374	TCF7L1	6	24	30	820.19
#375	DLX2	6	23	29	840.97
#376	NR1D2	6	21	27	729.229
#377	FOXL2	6	13	19	1234.041
#378	TFDP2	6	22	28	1416.722
#379	ZNF18	6	20	26	659.637
#380	GAS7	6	7	13	380.656
#381	PKNOX1	6	20	26	412.04
#382	SOX15	6	13	19	932.182
#383	DDIT3	6	16	22	701.016
#384	PBX4	6	16	22	233.248
#385	ATF2	6	18	24	379.775
#386	HOXD1	6	14	20	605.351
#387	TCF3	5	19	24	424.997
#388	ZNF140	5	21	26	1011.841
#389	ZNF187	5	19	24	845.43
#390	PLAGL2	5	20	25	465.519
#391	SALL1	5	8	13	269.943
#392	HLF	5	22	27	788.043
#393	PPARD	5	25	30	601.581
#394	SCML2	5	16	21	975.73
#395	ZNF639	5	27	32	685.066
#396	FOXP4	5	13	18	220.465
#397	GRHL3	5	28	33	1153.735
#398	SOX6	5	11	16	300.26
#399	MXD1	5	21	26	1181.151
#400	SOX10	5	6	11	272.766
#401	IRF7	5	29	34	2458.945
#402	MZF1	5	16	21	819.519
#403	OLIG2	5	4	9	39.373
#404	CBL	5	20	25	788.227
#405	FOXI1	5	18	23	488.592
#406	NFATC2	5	23	28	432.01
#407	CITED2	5	20	25	567.145
#408	ZGPAT	5	20	25	487.822
#409	ZNF148	5	12	17	171.152
#410	PAX8	4	12	16	167.664
#411	WT1	4	27	31	702.125
#412	MITF	4	25	29	724.004
#413	ARNTL	4	21	25	788.299
#414	RORC	4	15	19	108.919
#415	BNC1	4	6	10	41.771
#416	ARNT	4	18	22	201.938
#417	ZFPM2	4	10	14	523.286
#418	LHX9	4	9	13	265.51
#419	TFEB	4	29	33	358.733
#420	ZFHX4	4	16	20	308.88
#421	RXRB	4	20	24	186.799
#422	MLL	4	14	18	166.365
#423	PURB	4	19	23	413.94
#424	UBN1	4	16	20	179.672
#425	TFE3	4	21	25	229.198
#426	ZXDC	4	20	24	596.162
#427	KLF11	4	23	27	378.025
#428	HMGB1	4	23	27	621.527
#429	TFAM	4	19	23	400.788
#430	NKX2-1	3	8	11	57.534
#431	IRX1	3	13	16	830.396
#432	NFATC1	3	25	28	463.252
#433	NR0B1	3	13	16	511.513
#434	HOXB9	3	7	10	35.524
#435	ZNF268	3	21	24	248.463
#436	GTF2I	3	23	26	718.662
#437	ZNF256	3	14	17	254.497
#438	CSRNP3	3	5	8	178.388
#439	CREBL2	3	22	25	672.388
#440	MYCL1	3	18	21	462.379
#441	KLF2	3	23	26	444.655
#442	ZNF24	3	11	14	64.117
#443	ARX	3	16	19	227.486
#444	ELF5	3	26	29	341.987
#445	ATF5	3	19	22	296.34
#446	TCF7L2	3	20	23	1449.643
#447	FOXE1	3	11	14	187.856
#448	FOXN3	3	23	26	135.021
#449	MKX	3	25	28	439.934
#450	KLF3	3	15	18	181.79
#451	BCL11B	3	27	30	872.753
#452	NR1H3	3	21	24	1652.019
#453	NFIC	3	21	24	304.914
#454	SMAD9	3	26	29	394.167
#455	RB1	2	25	27	145.056
#456	MEF2D	2	19	21	346.722
#457	NFYA	2	20	22	85.339
#458	ZNF215	2	15	17	26.896
#459	EGR2	2	13	15	309.176
#460	FOXP2	2	9	11	156.538
#461	TCF7	2	16	18	403.528
#462	MEIS3	2	11	13	35.657
#463	TAF13	2	16	18	844.754
#464	ZNF70	2	22	24	615.355
#465	ZFP36L2	2	19	21	1338.156
#466	IRF5	2	18	20	517.342
#467	JUND	2	16	18	264.55
#468	SOX17	2	6	8	45.799
#469	ZNF323	2	26	28	105.834
#470	FOSB	2	11	13	552.929
#471	FOXA2	2	17	19	202.51
#472	KLF7	2	27	29	100.763
#473	ZKSCAN4	2	20	22	511.52
#474	TARDBP	2	21	23	112.683
#475	ASCL1	2	18	20	64.043
#476	ZC3H8	2	18	20	139.653
#477	SOX12	2	16	18	145.914
#478	NR5A2	2	13	15	430.919
#479	LZTR1	1	26	27	47.19
#480	NFAT5	1	25	26	35.388
#481	RERE	1	20	21	30.834
#482	EN2	1	16	17	59.452
#483	TSC22D4	1	20	21	64.431
#484	NR3C2	1	23	24	95.169
#485	HNF1B	1	8	9	1019.585
#486	SPEN	1	22	23	699.844
#487	HOXC12	1	7	8	3.789
#488	ATF3	1	22	23	81.56
#489	IRF2	1	19	20	60.659
#490	POU2F2	1	12	13	33.415
#491	TAL1	1	4	5	18.16
#492	NR4A1	1	17	18	1161.743
#493	NFKB2	1	22	23	1300.015
#494	MEOX1	1	4	5	49.304
#495	TSHZ3	1	9	10	46.575
#496	PBX2	0	21	21	0
#497	DLX4	0	18	18	0
#498	SUPT6H	0	25	25	0
#499	YY1	0	15	15	0
#500	ZNF33B	0	27	27	0