Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	EPAS1	54	1	55	12.764
#2	FOXN3	52	3	55	55.981
#3	EBF1	49	2	51	1841.879
#4	MEOX2	46	2	48	259.095
#5	TCF7L2	43	7	50	1559.97
#6	FOXO1	39	7	46	772.418
#7	ESR1	39	7	46	9948.751
#8	TRPS1	38	9	47	986.802
#9	TEAD1	38	8	46	479.492
#10	STAT5B	38	10	48	580.528
#11	CREB3L4	38	10	48	2852.207
#12	NR3C1	37	7	44	3646.512
#13	NFIA	35	9	44	4189.583
#14	AFF4	35	4	39	1230.857
#15	TSHZ2	35	7	42	4429.75
#16	SMAD9	35	8	43	298.244
#17	GATA3	35	10	45	7277.409
#18	SPDEF	33	6	39	288.8
#19	TWIST2	32	6	38	916.867
#20	STAT5A	31	8	39	802.914
#21	UHRF1	31	5	36	363.509
#22	KDM5B	31	9	40	2352.132
#23	PTTG1	30	6	36	472.578
#24	C5orf41	30	9	39	4462.217
#25	PPARG	30	4	34	40.092
#26	TCEAL1	28	8	36	1719.781
#27	ERG	28	7	35	152.69
#28	GRHL2	27	11	38	548.154
#29	MEF2C	27	10	37	1506.902
#30	FOXN2	27	8	35	443.946
#31	ADNP	27	11	38	2664.41
#32	IRX5	26	9	35	325.493
#33	TBX15	26	4	30	48.117
#34	MEIS2	26	10	36	563.309
#35	ATF1	25	9	34	1215.135
#36	MTA3	25	10	35	4068.576
#37	FLI1	25	9	34	821.832
#38	TFDP1	24	10	34	2757.009
#39	HOXA5	24	9	33	2044.164
#40	KLF11	24	7	31	149.941
#41	ELK1	24	4	28	682.46
#42	NFIB	24	10	34	493.858
#43	SATB1	24	10	34	4302.328
#44	ADNP2	24	0	24	0
#45	SP3	24	4	28	535.925
#46	SOX4	24	11	35	1969.809
#47	CNBP	23	12	35	1339.012
#48	LASS2	23	18	41	5691.218
#49	ETS2	23	8	31	185.671
#50	RBPJ	23	7	30	287.863
#51	HR	23	5	28	3121.994
#52	TFDP2	23	11	34	757.546
#53	MEOX1	23	7	30	778.019
#54	NFIL3	23	8	31	5669.043
#55	HNRNPAB	23	7	30	311.209
#56	ZNF33A	23	7	30	2303.684
#57	SOX7	21	8	29	590.612
#58	NFE2L2	21	4	25	279.146
#59	CEBPA	21	7	28	2104.199
#60	ZNF281	21	10	31	871.719
#61	MECOM	21	6	27	2992.414
#62	TFE3	21	9	30	1463.284
#63	MYBL2	21	4	25	237.271
#64	CEBPB	21	9	30	1182.916
#65	ENO1	21	13	34	5332.115
#66	NOLC1	21	11	32	1128.908
#67	NR3C2	20	19	39	4026.053
#68	E2F2	20	6	26	940.001
#69	ZEB2	20	7	27	120.05
#70	XBP1	20	10	30	862.239
#71	MEIS3P1	19	11	30	6861.097
#72	TSC22D1	19	12	31	2053.556
#73	ZNF217	19	9	28	973.244
#74	KLF4	19	12	31	1312.444
#75	KLF16	19	4	23	1043.203
#76	RXRA	19	7	26	684.928
#77	TCF4	19	8	27	1825.998
#78	FOXP2	19	14	33	2724.84
#79	TFAP4	19	3	22	314.081
#80	HLF	18	12	30	657.457
#81	ZNF148	18	9	27	648.302
#82	TCF3	18	12	30	1224.439
#83	HOXA3	18	13	31	485.749
#84	HMG20B	18	8	26	483.526
#85	HDAC2	18	6	24	1751.765
#86	SMAD4	18	12	30	4722.675
#87	BRD8	18	11	29	2021.478
#88	ZNF24	18	7	25	2296.219
#89	ELK3	18	9	27	1173.856
#90	CREBL2	18	9	27	1403.523
#91	HCLS1	18	7	25	930.844
#92	NFE2L1	18	9	27	3308.345
#93	NR1H3	18	12	30	1188.811
#94	LASS6	17	14	31	4343.001
#95	SNAI2	17	13	30	1802.601
#96	ZNF83	17	8	25	1911.677
#97	TULP4	17	3	20	185.565
#98	USF2	17	13	30	2044.796
#99	ZRANB2	17	6	23	641.525
#100	MAFB	17	19	36	4051.273
#101	ZFPM1	17	2	19	150.288
#102	HOXA10	17	10	27	1305.808
#103	FOXK2	17	12	29	4571.59
#104	RUNX1T1	17	8	25	973.096
#105	MLXIPL	17	10	27	2079.614
#106	KDM5A	17	7	24	3428.25
#107	TFAM	17	3	20	301.494
#108	ZNF236	17	5	22	2336.268
#109	KLF2	16	7	23	981.128
#110	POU5F1B	16	5	21	530.059
#111	HSF1	16	9	25	1308.257
#112	TFAP2C	16	13	29	766.335
#113	TFAP2A	16	11	27	3434.748
#114	JUN	16	9	25	1537.608
#115	DMTF1	16	11	27	1576.532
#116	RORC	16	10	26	1558.72
#117	NFYA	16	15	31	2974.753
#118	PAX8	16	3	19	176.645
#119	HOXA7	16	5	21	93.615
#120	ZC3H8	16	11	27	811.531
#121	TBX3	16	15	31	2838.432
#122	SMAD6	16	9	25	308.238
#123	PPARA	16	9	25	1648.242
#124	NFATC1	15	11	26	679.925
#125	KLF15	15	11	26	353.991
#126	ZNF445	15	4	19	494.585
#127	LCOR	15	6	21	488.726
#128	NFYB	15	9	24	4853.614
#129	MLLT10	15	13	28	1942.04
#130	RAX2	15	7	22	895.782
#131	AFF1	15	13	28	552.158
#132	ETS1	15	15	30	3237.715
#133	ETV7	15	8	23	1673.897
#134	CSDA	15	15	30	4678.437
#135	FOXC1	15	13	28	10031.342
#136	TCF7L1	15	13	28	359.14
#137	HIF1A	14	12	26	2192.2
#138	HIC1	14	8	22	864.24
#139	MZF1	14	7	21	957.638
#140	ZSCAN29	14	10	24	1582.638
#141	ZNF140	14	7	21	2584.854
#142	UBN1	14	7	21	917.865
#143	THRB	14	14	28	952.432
#144	MLL	14	13	27	930.944
#145	GABPB1	14	6	20	673.609
#146	KLF9	14	13	27	755.796
#147	SCML2	14	12	26	4514.319
#148	SOX10	14	7	21	1645.82
#149	TAF10	14	9	23	4994.727
#150	SUPT6H	13	9	22	1352.249
#151	ZNF93	13	13	26	1303.003
#152	LEF1	13	13	26	1196.82
#153	HEY1	13	15	28	1319.192
#154	BUD31	13	8	21	1565.34
#155	ZFPM2	13	12	25	273.858
#156	PEG3	13	17	30	6511.661
#157	E4F1	13	14	27	888.686
#158	ELF3	13	10	23	466.58
#159	ELF4	13	13	26	2473.447
#160	ZNF438	13	12	25	704.976
#161	ZNF138	13	13	26	813.335
#162	GTF2H4	13	15	28	2580.004
#163	RUNX3	13	3	16	731.184
#164	HMX1	13	6	19	1039.279
#165	HDAC1	13	14	27	1470.526
#166	PKNOX1	13	9	22	768.499
#167	AR	12	13	25	2016.95
#168	FOS	12	7	19	2508.318
#169	TCF20	12	13	25	1522.834
#170	IRF6	12	14	26	302.4
#171	FOXJ2	12	10	22	1287.22
#172	FOXA1	12	13	25	2462.06
#173	HOXA9	12	20	32	5118.881
#174	RUNX2	12	18	30	695.399
#175	IRX3	12	8	20	359.531
#176	STAT1	12	13	25	5000.736
#177	ARNT2	12	12	24	2456.822
#178	RCAN1	12	15	27	2462.62
#179	VDR	12	10	22	403.398
#180	SOX15	12	3	15	418.118
#181	SPEN	12	7	19	277.58
#182	LHX6	12	9	21	796.701
#183	CREB3L2	12	11	23	1272.345
#184	RFX5	12	17	29	695.431
#185	SCAND1	12	10	22	2298.569
#186	SLC2A4RG	12	5	17	2414.046
#187	TCF25	11	11	22	571.516
#188	E2F4	11	3	14	1002.396
#189	BATF	11	12	23	445.153
#190	MSX1	11	11	22	196.723
#191	KLF7	11	11	22	1569.877
#192	NR2C1	11	11	22	1214.573
#193	PRDM2	11	11	22	3580.085
#194	BHLHE41	11	11	22	1186.988
#195	MITF	11	14	25	508.244
#196	POU2F2	11	9	20	492.068
#197	ANKRD30A	11	15	26	746.6
#198	MLX	11	13	24	1122.114
#199	PLSCR1	11	11	22	4204.828
#200	BTG2	11	15	26	2529.372
#201	NFAT5	11	7	18	895.566
#202	ZNF444	11	9	20	1444.574
#203	IRF3	11	11	22	1689.532
#204	DRAP1	11	13	24	1363.645
#205	SNAPC2	11	8	19	1679.559
#206	ZNF238	11	18	29	11188.352
#207	GLIS2	11	10	21	3291.099
#208	ELF2	11	9	20	503.946
#209	FOXO6	11	9	20	2889.123
#210	CBFB	11	16	27	2456.582
#211	JUNB	10	8	18	299.305
#212	FOSB	10	9	19	230.094
#213	IRX1	10	13	23	541.548
#214	ATF3	10	8	18	932.835
#215	ZEB1	10	7	17	1039.582
#216	SMAD5	10	5	15	92.15
#217	MEIS1	10	5	15	484.814
#218	RUNX1	10	16	26	749.939
#219	IKZF1	10	7	17	678.867
#220	HOXD4	10	10	20	274.22
#221	ZNF91	10	15	25	1919.936
#222	ATF6	10	7	17	358.317
#223	JDP2	10	11	21	1662.557
#224	MTA1	10	13	23	3035.669
#225	AHR	10	9	19	601.182
#226	MAX	10	10	20	931.01
#227	TARDBP	10	15	25	1948.212
#228	TCF7	10	11	21	1735.926
#229	RBCK1	10	10	20	227.527
#230	NFATC3	10	12	22	2229.094
#231	ZNF274	10	12	22	2494.81
#232	CBL	10	10	20	897.823
#233	UBP1	10	10	20	4009.004
#234	PPARD	10	7	17	1140.121
#235	NPAT	10	14	24	2759.318
#236	NFYC	10	13	23	930.389
#237	RFX1	10	8	18	981.459
#238	E2F3	9	14	23	1255.377
#239	ZFHX4	9	11	20	363.731
#240	OVOL1	9	12	21	1576.256
#241	BCL6	9	11	20	467.038
#242	AATF	9	16	25	3597.227
#243	TCF15	9	8	17	989.972
#244	IRX2	9	12	21	1702.305
#245	PBX1	9	18	27	1684.499
#246	ZNF213	9	9	18	461.182
#247	CREM	9	11	20	1927.635
#248	RFXANK	9	10	19	222.187
#249	ZNF277	9	6	15	1104.125
#250	HMGA1	9	16	25	7672.859
#251	MESP1	9	13	22	375.1
#252	HMGB1	9	14	23	1595.38
#253	TSHZ1	9	19	28	3022.967
#254	NFX1	9	9	18	1633.36
#255	RCOR1	9	14	23	2479.108
#256	GTF2IRD1	9	13	22	1525.551
#257	HOXB2	9	9	18	3411.038
#258	CREB1	9	7	16	1905.037
#259	ZNF263	9	12	21	1116.58
#260	RELA	9	12	21	1316.512
#261	GATAD2A	9	11	20	1342.461
#262	NR2F6	9	10	19	3898.102
#263	POU6F1	9	13	22	763.107
#264	ZFP36L2	9	13	22	1606.946
#265	KLF10	9	10	19	553.064
#266	MAFF	9	11	20	497.934
#267	ZNF92	9	18	27	3219.364
#268	TRIM28	9	10	19	2422.959
#269	TEAD4	8	8	16	1111.526
#270	NR2C2	8	13	21	1188.382
#271	SP4	8	12	20	1628.705
#272	IRF7	8	16	24	3700.184
#273	AEBP1	8	14	22	4298.211
#274	TFAP2B	8	18	26	1286.202
#275	IRF8	8	12	20	1616.71
#276	RERE	8	11	19	422.037
#277	SMAD2	8	8	16	479.354
#278	CREBZF	8	15	23	2137.34
#279	ZFHX3	8	15	23	4170.848
#280	ESRRA	8	14	22	931.366
#281	FOXK1	8	15	23	1685.108
#282	TSHZ3	8	8	16	1050.977
#283	STAT2	8	10	18	1573.555
#284	DLX2	8	8	16	516.508
#285	GATAD1	8	13	21	2430.96
#286	RORA	8	22	30	893.364
#287	MAFK	8	11	19	1934.609
#288	CBFA2T2	8	14	22	964.646
#289	NR2F1	8	11	19	244.197
#290	SIX5	8	15	23	1996.601
#291	RARG	8	5	13	105.662
#292	TBX2	8	10	18	787.393
#293	ARX	8	7	15	683.937
#294	ZNF496	8	18	26	2827.379
#295	TFEB	8	10	18	1394.088
#296	YBX1	8	15	23	1559.988
#297	CLOCK	8	15	23	2218.017
#298	PROX1	8	9	17	694.091
#299	JUND	8	12	20	930.666
#300	AHCTF1	8	11	19	844.191
#301	CNOT7	7	14	21	2815.489
#302	WNT5A	7	18	25	5641.895
#303	PKNOX2	7	11	18	1282.043
#304	KLF12	7	14	21	3619.396
#305	TCF12	7	11	18	800.094
#306	EGR1	7	12	19	694.961
#307	ZFP90	7	12	19	1700.288
#308	ZNF394	7	11	18	2156.757
#309	THRA	7	12	19	333.074
#310	TEAD2	7	17	24	2159.376
#311	SOX9	7	23	30	3613.304
#312	NFIC	7	12	19	3668.151
#313	ZNF446	7	15	22	1475.711
#314	HSF4	7	11	18	718.066
#315	REST	7	13	20	1064.833
#316	TWIST1	7	12	19	747.208
#317	TRIM29	7	10	17	226.948
#318	SLC30A9	7	16	23	4566.044
#319	ZNF175	7	14	21	881.836
#320	NFKB2	7	12	19	552.76
#321	ZNF219	7	12	19	318.775
#322	HOXB7	7	15	22	2316.501
#323	MAF	7	15	22	2047.032
#324	ZBTB48	7	11	18	1484.98
#325	SMAD3	7	10	17	198.127
#326	CITED2	7	18	25	4346.996
#327	MSRB2	7	21	28	2554.244
#328	GABPA	7	7	14	955.587
#329	YY1	7	9	16	1145.121
#330	ZSCAN18	7	16	23	1330.104
#331	TAF7	7	9	16	1037.89
#332	TADA3	7	13	20	2452.997
#333	STRN3	7	10	17	654.956
#334	HOXA2	7	12	19	1369.202
#335	PCGF2	7	12	19	2362.932
#336	TGIF1	7	11	18	742.651
#337	TRIM22	6	10	16	1337.16
#338	TEF	6	12	18	352.905
#339	SREBF1	6	13	19	2680.31
#340	GLI3	6	18	24	1324.97
#341	KLF3	6	11	17	1170.868
#342	GTF2H2	6	8	14	1278.147
#343	FOXP4	6	19	25	1156.147
#344	C1orf85	6	15	21	2775.283
#345	BACH1	6	15	21	808.989
#346	FOXO3	6	15	21	1647.83
#347	KLF6	6	14	20	1631.409
#348	ZNF639	6	11	17	521.401
#349	PRDM1	6	15	21	634.672
#350	MYNN	6	16	22	3980.768
#351	MAFG	6	13	19	822.676
#352	MMP14	6	14	20	1718.219
#353	ETV5	6	10	16	809.795
#354	NFXL1	6	15	21	6814.926
#355	DDIT3	6	12	18	1192.863
#356	ZNF134	6	11	17	2872.106
#357	E2F6	6	17	23	960.827
#358	NR4A1	6	5	11	100.409
#359	SIN3A	6	16	22	2163.271
#360	ZHX2	6	16	22	1737.635
#361	MSL3	6	16	22	2806.249
#362	PBX2	6	14	20	1532.66
#363	NFKB1	6	11	17	734.487
#364	ZBTB17	6	8	14	1058.191
#365	HMGB2	6	18	24	913.528
#366	SCML1	6	18	24	1126.334
#367	TSC22D3	6	12	18	484.416
#368	IRF9	6	9	15	859.115
#369	GTF2I	6	8	14	1214.74
#370	RARA	5	10	15	1545.951
#371	MBD1	5	12	17	1588.068
#372	REL	5	12	17	314.285
#373	FUBP1	5	12	17	344.103
#374	FOSL2	5	15	20	892.433
#375	ZNF434	5	10	15	626.379
#376	ZBTB38	5	6	11	881.597
#377	TBX5	5	13	18	156.161
#378	ATF4	5	12	17	678.917
#379	LZTR1	5	17	22	1019.876
#380	ZNF131	5	8	13	195.97
#381	ZNF133	5	8	13	493.704
#382	IRF2	5	7	12	656.433
#383	SREBF2	5	15	20	2121.869
#384	CEBPD	5	12	17	403.768
#385	EGR2	5	11	16	366.097
#386	ZNF397	5	8	13	118.754
#387	HOXB3	5	11	16	1640.39
#388	HOXB6	5	13	18	1399.161
#389	TP63	5	13	18	157.041
#390	TEAD3	5	12	17	599.91
#391	CSRNP1	5	11	16	423.656
#392	NOTCH1	5	12	17	609.8
#393	ZKSCAN1	5	13	18	628.426
#394	HSF2	5	12	17	506.105
#395	CDKN2A	5	15	20	487.086
#396	ZGLP1	5	12	17	1576.341
#397	ATF5	5	10	15	1116.587
#398	CNOT8	5	10	15	1433.174
#399	TRIM25	5	17	22	1986.292
#400	FOXO4	5	10	15	717.946
#401	NR1D2	5	14	19	402.13
#402	CUX1	5	12	17	4202.059
#403	PURA	5	12	17	518.929
#404	PURB	5	12	17	103.514
#405	GCFC1	5	13	18	897.568
#406	BTAF1	5	12	17	780.48
#407	TGIF2	4	12	16	302.492
#408	NR4A2	4	10	14	300.323
#409	EGR3	4	14	18	281.545
#410	TAF12	4	14	18	609.549
#411	RB1	4	15	19	693.774
#412	MXD1	4	17	21	4458.826
#413	NR2F2	4	17	21	2280.685
#414	ELF1	4	11	15	370.384
#415	TP53	4	14	18	2973.069
#416	CREB3L1	4	17	21	1435.658
#417	CREBBP	4	20	24	1200.035
#418	CSRNP2	4	15	19	766.453
#419	SUPT4H1	4	11	15	179.035
#420	FBXW7	4	13	17	208.805
#421	ZNF85	4	15	19	523.425
#422	PRRX2	4	15	19	1462.187
#423	EHF	4	13	17	91.426
#424	ELF5	4	17	21	314.33
#425	CTNNB1	4	19	23	1606.838
#426	STAT3	4	9	13	532.82
#427	HOXC10	4	18	22	384.269
#428	HHEX	4	13	17	877.794
#429	SALL2	4	11	15	1169.718
#430	NCOR1	4	11	15	1530.857
#431	TAF4	3	10	13	1546.77
#432	HOXD8	3	21	24	400.318
#433	MTF1	3	11	14	106.61
#434	NR1H2	3	13	16	456.507
#435	GATA2	3	13	16	1052.141
#436	ZNF45	3	14	17	475.956
#437	NR4A3	3	21	24	377.759
#438	ARNTL	3	13	16	186.808
#439	PRRX1	3	18	21	934.138
#440	GAS7	3	13	16	119.924
#441	MEIS3	3	13	16	906.921
#442	NFATC4	3	12	15	397.505
#443	STAT6	3	12	15	145.963
#444	ZNF207	3	12	15	638.586
#445	SIX4	3	17	20	527.604
#446	CREB3	3	13	16	141.8
#447	NFIX	3	15	18	382.182
#448	ZHX1	3	13	16	291.535
#449	PGR	3	20	23	453.779
#450	SMAD1	3	18	21	413.002
#451	ERF	2	9	11	69.32
#452	BCL3	2	10	12	99.946
#453	HOXB4	2	14	16	154.776
#454	BHLHE40	2	13	15	147.818
#455	FOXP1	2	17	19	854.742
#456	ATF2	2	13	15	4119.309
#457	ETV1	2	16	18	751.949
#458	HEY2	2	14	16	111.785
#459	ZNF187	2	11	13	308.553
#460	TFCP2L1	2	13	15	620.376
#461	ETV6	2	16	18	98.081
#462	SOX13	2	14	16	498.517
#463	TFCP2	2	9	11	1610.15
#464	PA2G4	2	11	13	133.293
#465	SIX1	2	19	21	589.531
#466	PHF5A	2	12	14	739.699
#467	PHF1	2	9	11	1813.541
#468	ZNF117	1	18	19	1601.558
#469	ZNF232	1	11	12	1640.485
#470	HMBOX1	1	13	14	594.051
#471	HES1	1	14	15	21.013
#472	CITED1	1	14	15	1005.865
#473	HINFP	1	13	14	60.874
#474	LMO4	1	11	12	1623.588
#475	MGA	1	14	15	41.991
#476	HOPX	1	17	18	838.981
#477	GTF2H3	1	10	11	245.613
#478	SP1	1	15	16	491.324
#479	HOXD9	1	13	14	1337.044
#480	MYC	1	21	22	495.587
#481	ZFP36L1	1	18	19	154.42
#482	TSC22D2	1	9	10	42.259
#483	IRF5	1	17	18	101.478
#484	CTBP1	1	16	17	1127.569
#485	HIRA	1	10	11	43.085
#486	BATF3	1	12	13	74.625
#487	ARNT	1	10	11	1087.895
#488	ATF7	1	15	16	114.374
#489	PBX3	1	14	15	325.434
#490	NFATC2	1	10	11	1130.344
#491	ZNF323	0	9	9	0
#492	IRF1	0	13	13	0
#493	HOXC4	0	8	8	0
#494	DBP	0	14	14	0
#495	TAF6	0	13	13	0
#496	C2orf3	0	9	9	0
#497	SRF	0	10	10	0
#498	ZNF268	0	15	15	0
#499	MEF2A	0	12	12	0
#500	TCFL5	0	13	13	0