Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	FOXJ1	51	14	65	5027.957
#2	C2orf3	40	9	49	740.684
#3	SMAD6	39	3	42	244.848
#4	NKX6-2	38	1	39	37.939
#5	CBFA2T3	37	5	42	437.685
#6	PKNOX1	36	7	43	700.247
#7	GLIS3	36	12	48	2929.421
#8	CBFB	35	2	37	64.915
#9	IKZF3	35	12	47	1041.33
#10	MTF1	35	10	45	812.362
#11	ZNF93	34	5	39	281.597
#12	HOXB3	34	8	42	10636.519
#13	SMAD3	34	12	46	756.275
#14	NFE2L2	33	1	34	32.177
#15	ATF4	32	11	43	886.517
#16	TBX3	32	9	41	601.889
#17	TFAP2C	32	10	42	752.569
#18	ETV3L	32	5	37	591.935
#19	RFX1	31	13	44	1728.838
#20	FOXL1	31	3	34	104.399
#21	TBP	31	3	34	166.49
#22	HIF3A	30	11	41	1367.776
#23	PHF5A	30	4	34	1719.861
#24	SRF	29	2	31	567.672
#25	IRX4	29	12	41	5993.307
#26	E4F1	29	10	39	2312.658
#27	ETV6	29	4	33	190.399
#28	MNT	28	6	34	10802.601
#29	ZNF496	28	9	37	4118.134
#30	IRF7	28	6	34	1546.416
#31	ZKSCAN1	28	4	32	112.83
#32	RBPJ	27	8	35	10990.665
#33	SATB2	27	11	38	8505.571
#34	SIM2	27	11	38	8172.94
#35	CITED2	26	10	36	728.119
#36	GCM1	26	12	38	2347.278
#37	SREBF2	26	7	33	1369.292
#38	AFF4	26	10	36	1537.733
#39	CTCF	26	19	45	2297.258
#40	POU4F2	26	4	30	168.874
#41	HOXB2	26	7	33	1050.323
#42	LHX1	25	8	33	1014.533
#43	STAT3	25	3	28	161.538
#44	TSC22D4	25	11	36	594.385
#45	MSL3	25	2	27	41.608
#46	ZBTB48	25	14	39	1228.286
#47	GSC2	25	7	32	2474.916
#48	NME2	24	7	31	819.173
#49	BTAF1	24	11	35	913.983
#50	TFEC	24	7	31	1118.631
#51	ZNF135	24	7	31	354.271
#52	TRIM29	24	8	32	894.44
#53	ZNF213	24	17	41	1184.511
#54	HCFC1	24	13	37	6498.739
#55	ZXDC	24	10	34	4081.352
#56	HOXC11	23	6	29	485.289
#57	MEIS3	23	12	35	333.21
#58	CREBL2	23	14	37	1685.529
#59	THRA	23	4	27	145.637
#60	TCF7L2	23	22	45	3334.07
#61	MSC	23	0	23	0
#62	EVX1	23	13	36	766.795
#63	ATF7	23	8	31	2547.184
#64	TFAP2B	22	16	38	3380.818
#65	MECOM	22	12	34	2694.543
#66	NR1I3	22	11	33	2409.68
#67	NPAT	22	14	36	1065.231
#68	NR2E3	22	8	30	255.7
#69	NKX2-3	22	5	27	733.595
#70	RFX5	22	13	35	590.766
#71	HOXD11	22	2	24	34.443
#72	SIX1	22	4	26	145.491
#73	TCF12	22	14	36	1694.289
#74	XBP1	22	7	29	808.982
#75	SOX10	22	12	34	2339.512
#76	FOXQ1	21	5	26	169.607
#77	HESX1	21	10	31	518.879
#78	KDM5B	21	11	32	1516.676
#79	GATAD2A	21	11	32	954.123
#80	CNBP	21	10	31	1131.646
#81	IRX2	21	19	40	1949.244
#82	MLXIPL	21	7	28	168.804
#83	FEV	21	23	44	2085.122
#84	IRF2	21	1	22	9.864
#85	POU6F1	21	6	27	335.716
#86	DLX6	21	17	38	1239.448
#87	OVOL1	21	9	30	2250.592
#88	SOX30	21	5	26	298.326
#89	ESRRG	21	11	32	1485.368
#90	TARDBP	21	14	35	2621.822
#91	FOXO1	20	3	23	58.164
#92	STAT2	20	2	22	2987.075
#93	PPARG	20	14	34	1894.799
#94	KLF6	20	6	26	294.048
#95	TP63	20	10	30	871.054
#96	GTF2IRD1	20	8	28	259.834
#97	SUPT6H	20	4	24	207.743
#98	ZBTB38	20	8	28	665.879
#99	POU5F1	20	13	33	4353.425
#100	RORA	20	18	38	784.409
#101	ZNF165	20	7	27	696.372
#102	ELF1	20	16	36	13242.451
#103	HOXC13	20	5	25	230.373
#104	ZNF37A	20	16	36	658.872
#105	TGIF2LY	20	1	21	11.104
#106	CREB3L2	20	18	38	3090.177
#107	HOXB7	19	5	24	238.924
#108	STAT5B	19	17	36	1867.47
#109	E2F4	19	10	29	4180.078
#110	GLIS2	19	7	26	292.524
#111	ZNF131	19	14	33	1118.383
#112	MYC	19	11	30	594.201
#113	THRB	19	9	28	2158.17
#114	ZNF236	19	13	32	1703.569
#115	NR3C1	19	4	23	90.53
#116	TBX2	19	7	26	320.46
#117	MNX1	19	4	23	283.971
#118	EMX1	19	12	31	810.874
#119	CREB3L3	19	8	27	322.721
#120	SPDEF	18	14	32	662.522
#121	HOXD1	18	19	37	747.426
#122	SP3	18	17	35	350.929
#123	FOXP4	18	15	33	2274.855
#124	STRN3	18	13	31	3221.085
#125	MEF2D	18	4	22	58.689
#126	ZSCAN18	18	6	24	234.073
#127	ZGPAT	18	7	25	954.151
#128	SOX6	18	9	27	467.794
#129	FBXW7	17	16	33	1747.454
#130	FOXC1	17	10	27	1273.609
#131	SOLH	17	4	21	11294.215
#132	ZXDA	17	11	28	1217.488
#133	KLF5	17	18	35	2191.75
#134	STAT6	17	7	24	758.673
#135	STAT4	17	14	31	904.404
#136	ZFP36L1	17	11	28	755.985
#137	FOXP3	17	17	34	725.914
#138	HEY2	17	14	31	1988.783
#139	ZNF24	17	7	24	990.032
#140	FOXO4	17	14	31	1555.251
#141	RCOR1	17	11	28	1822.585
#142	KLF11	17	24	41	1497.577
#143	SHOX	16	14	30	819.224
#144	PHOX2B	16	7	23	119.564
#145	ETV5	16	11	27	926.45
#146	TP53	16	13	29	14775.297
#147	PRDM2	16	14	30	770.969
#148	MLLT10	16	13	29	978.421
#149	ATF3	16	13	29	869.662
#150	CREM	16	11	27	1889.023
#151	C12orf28	16	16	32	1870.998
#152	LASS2	16	6	22	5264.98
#153	ESRRA	16	10	26	1116.383
#154	IRF5	16	7	23	407.638
#155	IKZF4	16	22	38	1440.577
#156	ZNF281	16	16	32	549.112
#157	SP140	16	18	34	1350.934
#158	VSX1	16	8	24	603.355
#159	ZNF33B	16	8	24	205.743
#160	BATF	16	18	34	1936.405
#161	NFATC1	16	5	21	1241.466
#162	PLSCR1	16	13	29	1627.807
#163	MTA1	15	5	20	166.769
#164	IRX6	15	6	21	125.756
#165	KLF3	15	22	37	1363.994
#166	HOXD8	15	9	24	1277.617
#167	TSHZ3	15	9	24	320.25
#168	ZKSCAN4	15	5	20	1046.644
#169	SCML1	15	12	27	3184.613
#170	VDR	15	4	19	3441.366
#171	CBL	15	10	25	1657.631
#172	ZNF167	15	3	18	231.099
#173	BUD31	15	19	34	5596.67
#174	SLC2A4RG	15	4	19	252.462
#175	FOXA1	15	18	33	2479.173
#176	HOXA4	15	13	28	5710.752
#177	TBX5	15	12	27	1500.778
#178	FOXJ2	15	13	28	2794.369
#179	LMO4	15	12	27	780.842
#180	NR1D2	15	13	28	3220.135
#181	KCNH8	15	9	24	299.741
#182	RFX3	14	12	26	613.047
#183	TEF	14	13	27	746.499
#184	HES5	14	21	35	2306.796
#185	POU2F1	14	14	28	1287.268
#186	EGR3	14	15	29	1665.381
#187	HIF1A	14	16	30	1645.636
#188	HOXC9	14	9	23	984.87
#189	NR1D1	14	4	18	71.187
#190	E2F1	14	9	23	1237.033
#191	NR2E1	14	9	23	2516.353
#192	SUPT4H1	14	11	25	555.268
#193	SMAD4	14	22	36	1331.488
#194	HMGA1	14	12	26	392.06
#195	SMAD2	14	12	26	5361.425
#196	EGR1	14	7	21	1417.004
#197	FOXA2	14	9	23	205.987
#198	DLX3	14	9	23	411.34
#199	TEAD3	13	8	21	860.836
#200	ELF4	13	7	20	2067.959
#201	MESP1	13	16	29	529.61
#202	MEIS2	13	6	19	217.253
#203	SIN3A	13	6	19	1043.658
#204	TWIST1	13	9	22	287.886
#205	MYOG	13	8	21	174.341
#206	TCEAL1	13	7	20	3100.409
#207	ZNF434	13	18	31	1889.051
#208	HIRA	13	11	24	235.906
#209	ZNF202	13	12	25	1247.92
#210	ZSCAN16	13	10	23	983.584
#211	FOXP2	13	14	27	416.436
#212	TAF4B	13	11	24	1794.074
#213	YY1	13	15	28	1763.782
#214	REXO4	13	6	19	2427.063
#215	HNF4A	13	9	22	5558.389
#216	NR2F2	13	13	26	1029.556
#217	SCAND1	13	6	19	1381.164
#218	SOX5	13	9	22	204.841
#219	GATA1	12	13	25	6326.903
#220	IKZF1	12	10	22	206.317
#221	HOPX	12	14	26	1313.049
#222	ZNF197	12	5	17	1599.691
#223	ELK4	12	6	18	680.344
#224	RNF4	12	2	14	418.133
#225	HES6	12	7	19	367.476
#226	NPAS1	12	11	23	2086.729
#227	ZNF277	12	11	23	373.351
#228	ZRANB2	12	11	23	2523.223
#229	BCL11B	12	9	21	284.493
#230	POU2F3	12	11	23	1597.838
#231	JUNB	12	10	22	1166.812
#232	TBX19	12	16	28	491.818
#233	E2F7	12	6	18	1187.673
#234	RB1	12	12	24	806.883
#235	DMTF1	12	15	27	1299.984
#236	NFX1	12	21	33	4054.413
#237	HDAC1	12	13	25	401.139
#238	ZNF90	12	19	31	643.076
#239	CDX2	12	10	22	547.697
#240	PPARA	12	13	25	1037.545
#241	SOX13	12	4	16	326.63
#242	SCML2	12	14	26	1363.352
#243	SPIB	11	1	12	17.709
#244	IRX5	11	8	19	246.581
#245	FOXR1	11	6	17	1103.265
#246	ZNF19	11	16	27	817.747
#247	TBX22	11	16	27	991.171
#248	CUX2	11	15	26	1821.25
#249	ZSCAN2	11	10	21	1348.793
#250	GTF2I	11	8	19	4740.998
#251	ZEB2	11	20	31	1248.108
#252	RCAN1	11	7	18	222.948
#253	NOLC1	11	19	30	2480.611
#254	PPARD	11	13	24	397.488
#255	UBN1	11	12	23	1586.448
#256	CTBP1	11	7	18	185.275
#257	LASS6	11	11	22	5181.558
#258	NFYA	11	13	24	1318.896
#259	EBF1	11	5	16	1861.018
#260	POU4F3	10	16	26	4423.903
#261	FOXK2	10	13	23	2988.809
#262	GRHL2	10	23	33	684.641
#263	ETV7	10	18	28	628.852
#264	GABPA	10	25	35	2324.442
#265	FOXH1	10	18	28	1371.106
#266	HNF4G	10	4	14	2078.333
#267	TFE3	10	12	22	8560.634
#268	NFAT5	10	11	21	1383.978
#269	GAS7	10	19	29	1475.538
#270	RUNX1	10	16	26	664.45
#271	SCAND3	10	14	24	643.182
#272	PA2G4	10	14	24	718.489
#273	SOX4	10	14	24	962.356
#274	HINFP	10	18	28	440.313
#275	ZNF133	10	15	25	857.333
#276	PITX1	10	5	15	13676.266
#277	SIX4	10	14	24	1776.862
#278	HNF1A	10	14	24	249.769
#279	MAF	10	17	27	993.617
#280	ASCL2	10	9	19	3062.103
#281	GABPB1	10	11	21	726.856
#282	SOX15	9	16	25	817.697
#283	POU3F4	9	17	26	1113.628
#284	HNRNPK	9	6	15	82.348
#285	DDIT3	9	18	27	523.622
#286	TBX10	9	14	23	6628.371
#287	NANOGP1	9	25	34	1420.049
#288	MMP14	9	8	17	549.98
#289	PURB	9	14	23	1247.577
#290	ESR1	9	13	22	644.726
#291	ETV1	9	9	18	354.909
#292	C1orf85	9	12	21	1218.929
#293	AHCTF1	9	17	26	2231.633
#294	NFYB	9	9	18	746.675
#295	TP73	9	9	18	1196.635
#296	NFKB1	9	17	26	328.479
#297	KLF12	9	5	14	188.559
#298	NFIA	9	18	27	475.507
#299	TSHZ2	9	0	9	0
#300	TAF13	9	9	18	209.027
#301	MXD1	9	14	23	1823.623
#302	TMEM229A	9	10	19	2491.915
#303	SNAI2	9	4	13	1180.469
#304	ZNF18	9	15	24	369.469
#305	IRF3	9	15	24	1579.235
#306	NKX6-1	9	2	11	50.456
#307	ALS2CR8	8	9	17	331.641
#308	TSC22D2	8	15	23	4141.236
#309	NR1H4	8	7	15	100.955
#310	NFIC	8	15	23	2337.744
#311	NFYC	8	15	23	7290.603
#312	ZNF263	8	16	24	503.785
#313	SOX12	8	11	19	2532.256
#314	ZKSCAN5	8	15	23	2199.815
#315	HOXB4	8	16	24	2619.846
#316	ZSCAN21	8	20	28	963.307
#317	TAF1B	8	14	22	97.524
#318	TGIF2	8	12	20	648.338
#319	TCF25	8	17	25	445.296
#320	RERE	8	20	28	1176.768
#321	ZNF45	8	23	31	760.686
#322	ZFHX4	8	20	28	295.106
#323	MYCN	8	16	24	315.189
#324	MYCL1	8	6	14	146.171
#325	SIX6	8	16	24	1793.103
#326	TAF7	8	12	20	585.62
#327	MLL	8	11	19	8282.481
#328	NEUROD1	8	19	27	1198.004
#329	TBR1	8	22	30	942.095
#330	GATAD1	8	15	23	761.583
#331	RUNX3	8	17	25	478.317
#332	JUN	7	13	20	396.081
#333	TFAM	7	25	32	3614.919
#334	SOX9	7	3	10	8.758
#335	ELK1	7	24	31	2826.494
#336	ERF	7	12	19	193.608
#337	TFAP2A	7	19	26	3796.595
#338	DBP	7	13	20	1588.581
#339	MSX2	7	11	18	559.969
#340	LASS5	7	9	16	705.49
#341	MYF6	7	20	27	2721.472
#342	NFIX	7	18	25	630.813
#343	ARX	7	17	24	257.099
#344	MTA3	7	20	27	535.091
#345	RORB	7	16	23	321.22
#346	EGR4	7	20	27	11778.541
#347	SMAD5	6	7	13	712.062
#348	ZSCAN5A	6	12	18	3083.163
#349	CTNNB1	6	5	11	766.449
#350	CSDA	6	8	14	2594.977
#351	HES1	6	14	20	1311.056
#352	POU2F2	6	19	25	722.091
#353	NKX2-1	6	21	27	402.874
#354	ZNF217	6	24	30	981.766
#355	ZBTB25	6	16	22	279.534
#356	CDKN2A	6	19	25	1345.439
#357	TRIM22	6	15	21	470.639
#358	MZF1	6	22	28	670.957
#359	ASCL1	6	15	21	708.855
#360	GBX1	6	26	32	7802.584
#361	TBX21	6	18	24	780.202
#362	HOXA5	6	8	14	3943.023
#363	ZNF483	6	20	26	571.951
#364	CREBBP	6	3	9	158.041
#365	KLF4	6	5	11	70.651
#366	SIX3	6	11	17	12519.486
#367	POU1F1	6	3	9	124.585
#368	ZNF287	6	17	23	20126.511
#369	ZIC5	6	15	21	1107.032
#370	NRL	6	11	17	2513.746
#371	FOSB	6	4	10	1351.568
#372	PKNOX2	6	15	21	1468.816
#373	CEBPA	6	18	24	2144.314
#374	RUNX1T1	6	21	27	4489.968
#375	ZEB1	6	16	22	200.975
#376	HOXA13	6	12	18	481.773
#377	CEBPB	6	28	34	3446.262
#378	CREB3L1	6	20	26	986.697
#379	HOXD4	5	14	19	1596.459
#380	MAFB	5	18	23	355.314
#381	VAX2	5	18	23	982.298
#382	ZIM2	5	15	20	1397.621
#383	ZHX3	5	15	20	215.715
#384	HMGB1	5	19	24	664
#385	SP1	5	6	11	130.696
#386	RUNX2	5	15	20	559.943
#387	SNAPC5	5	14	19	389.908
#388	HOXC4	5	10	15	225.549
#389	ERG	5	20	25	653.918
#390	LHX9	5	9	14	123.51
#391	TFEB	5	15	20	620.396
#392	ELF5	5	7	12	88.217
#393	ZNF174	5	19	24	1180.765
#394	EN1	5	16	21	162.99
#395	HNF1B	5	19	24	747.237
#396	FOXD4	5	17	22	468.501
#397	KLF2	5	14	19	198.484
#398	NFIB	5	4	9	414.946
#399	TAL1	5	16	21	404.013
#400	ETV3	5	6	11	843.594
#401	RXRA	5	6	11	1169.431
#402	TRIM28	5	23	28	882.64
#403	TSHZ1	5	18	23	212.69
#404	ARNTL2	5	20	25	393.133
#405	OTX1	5	24	29	250.914
#406	SPEN	5	18	23	625.031
#407	SOX11	5	5	10	999.77
#408	USF2	5	15	20	504.54
#409	ZNF75D	5	4	9	2297.06
#410	DLX2	5	23	28	1107.578
#411	HMGA2	5	19	24	176.715
#412	ZNF274	5	20	25	1444.781
#413	FOXM1	5	9	14	52.772
#414	SMAD1	5	12	17	137.65
#415	ESR2	5	18	23	1285.139
#416	MITF	5	20	25	496.149
#417	MSX1	4	22	26	549.092
#418	HOXA10	4	23	27	1975.045
#419	IRX1	4	16	20	1322.873
#420	LZTR1	4	19	23	2546.935
#421	AEBP1	4	20	24	972.803
#422	MGA	4	17	21	1315.797
#423	FOXN2	4	20	24	889.153
#424	STAT1	4	17	21	370.138
#425	ZIC3	4	20	24	181.113
#426	SIM1	4	17	21	84.802
#427	RHOXF2	4	17	21	8501.637
#428	PROX1	4	20	24	5483.658
#429	E2F3	4	15	19	2083.22
#430	CSRNP1	4	4	8	434.755
#431	SALL1	4	16	20	863.847
#432	SOX7	4	2	6	17
#433	SMAD9	4	18	22	357.165
#434	GATA2	4	20	24	397.622
#435	TCFL5	4	17	21	166.876
#436	NR4A1	4	10	14	66.252
#437	HMX2	4	17	21	160.782
#438	TCF19	4	13	17	4527.958
#439	TRERF1	4	16	20	180.623
#440	ZC3H8	4	5	9	426.052
#441	NR2F6	4	6	10	1281.324
#442	BLZF1	4	12	16	101.421
#443	ZNF33A	4	26	30	4123.574
#444	ZNF445	4	9	13	237.455
#445	ADNP2	3	19	22	755.524
#446	TAF5L	3	23	26	1255.664
#447	GCFC1	3	24	27	483.027
#448	BARHL2	3	34	37	590.271
#449	NOTCH1	3	24	27	328.178
#450	TADA2A	3	5	8	427.787
#451	FOXJ3	3	13	16	422.829
#452	GSX1	3	5	8	657.588
#453	CREB3	3	21	24	1232.536
#454	AR	3	7	10	135.008
#455	ZNF187	3	24	27	903.264
#456	PAX8	3	6	9	89.78
#457	AFF1	3	21	24	1422.522
#458	FOXI3	3	11	14	63.784
#459	ZNF138	3	17	20	83.017
#460	NFKB2	3	27	30	279.216
#461	ZNF639	3	16	19	2639.744
#462	PAX5	3	13	16	73.018
#463	PRRX2	3	14	17	1442.832
#464	PLAGL2	3	24	27	142.077
#465	ZIC1	2	22	24	144.495
#466	HMX1	2	8	10	21.466
#467	NCOR1	2	5	7	565.198
#468	PBX4	2	29	31	15487.332
#469	TBX15	2	7	9	11168.441
#470	FLI1	2	15	17	4409.246
#471	UBP1	2	22	24	110.867
#472	NR0B1	2	8	10	51.036
#473	RELB	2	20	22	1339.39
#474	FOXD1	2	22	24	449.126
#475	ZNF238	2	16	18	132.382
#476	TCF4	2	23	25	807.501
#477	SNAI3	2	17	19	93.089
#478	IRX3	2	18	20	759.725
#479	TCF7	2	6	8	35.613
#480	ATF2	2	23	25	104.816
#481	ST18	2	22	24	145.256
#482	MLX	2	8	10	19.094
#483	FOXE1	2	6	8	37.466
#484	ZSCAN29	2	16	18	1354.921
#485	MIXL1	1	7	8	6.613
#486	CEBPE	1	18	19	59.968
#487	KLF10	1	28	29	64.852
#488	KLF15	1	24	25	77.567
#489	ESRRB	1	23	24	4183.931
#490	RELA	1	18	19	32.974
#491	CSRNP2	1	21	22	488.401
#492	TRPS1	1	14	15	80.892
#493	MAFK	0	27	27	0
#494	ARNTL	0	7	7	0
#495	ZNF215	0	16	16	0
#496	NPAS2	0	4	4	0
#497	CREBZF	0	22	22	0
#498	ELF2	0	25	25	0
#499	MBD1	0	9	9	0
#500	RFXANK	0	19	19	0