Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	NR2F2	43	9	52	1115.737
#2	EPAS1	41	9	50	1568.912
#3	ZEB1	41	7	48	1164.476
#4	NR2F6	41	4	45	358.839
#5	TCEAL1	39	2	41	272.341
#6	ZEB2	38	5	43	2424.638
#7	CREB3L1	36	6	42	1473.475
#8	HOXA10	36	6	42	3954.355
#9	ZNF91	35	5	40	3150.798
#10	AFF1	35	5	40	2853.455
#11	NFIL3	35	15	50	2285.699
#12	CSDA	35	5	40	345.314
#13	TWIST1	34	11	45	1396.983
#14	CITED2	33	9	42	1080.885
#15	MEIS3P1	33	4	37	464.983
#16	HCLS1	31	4	35	243.839
#17	NR3C1	31	7	38	1969.213
#18	FOSL2	30	7	37	1012.494
#19	BCL6	30	10	40	2597.611
#20	IRF9	30	9	39	968.973
#21	RCAN1	30	7	37	600.187
#22	MAFF	29	9	38	1131.694
#23	ZBTB38	28	14	42	3096.18
#24	ZNF232	28	12	40	2433.504
#25	MEIS1	28	11	39	2564.703
#26	FOXD1	28	12	40	1703.678
#27	FOSL1	28	8	36	1053.546
#28	TAF4B	27	4	31	917.889
#29	KLF11	27	10	37	3922.211
#30	TCF4	27	8	35	2236.578
#31	HNRNPAB	26	10	36	980.336
#32	AHR	26	9	35	4127.639
#33	ZFP36L1	26	8	34	802.041
#34	ARNT2	26	12	38	1268.201
#35	TCF7L1	26	6	32	373.709
#36	ELF1	25	10	35	1691.57
#37	PEG3	25	7	32	1498.876
#38	SNAI2	25	10	35	916.275
#39	ELK3	25	9	34	1737.945
#40	TEAD4	25	14	39	2125.291
#41	TCF3	25	8	33	1319.643
#42	TGIF1	24	5	29	1712.77
#43	IRF6	24	6	30	1284.284
#44	ETS1	24	10	34	1018.749
#45	RUNX1	24	13	37	1306.579
#46	FOXL2	24	9	33	1436.603
#47	ZXDC	23	5	28	307.629
#48	E2F8	23	3	26	458.28
#49	KLF2	22	9	31	814.62
#50	NPAS2	22	9	31	1176.529
#51	SCML1	22	8	30	555.353
#52	PRRX2	22	9	31	1136.336
#53	SMAD3	22	6	28	399.321
#54	MYCN	21	8	29	645.359
#55	TEAD3	21	7	28	399.858
#56	PRRX1	21	10	31	582.245
#57	TSC22D1	21	13	34	1026.445
#58	MYBL2	21	13	34	1435.664
#59	RXRA	21	9	30	513.34
#60	MEF2A	21	14	35	1749.45
#61	ELF3	21	9	30	1118.227
#62	HMGA2	21	14	35	3144.969
#63	E4F1	20	5	25	412.904
#64	ZNF83	20	11	31	2621.389
#65	THRA	20	11	31	3091.973
#66	MAF	20	10	30	1404.447
#67	POU3F2	20	7	27	949.365
#68	SALL2	20	10	30	914.309
#69	NR2F1	20	8	28	520.345
#70	BHLHE40	19	15	34	2930.358
#71	CEBPD	19	14	33	1893.727
#72	HR	19	9	28	713.565
#73	CUX1	19	16	35	2919.307
#74	IRX5	19	10	29	1045.06
#75	HOXA4	19	10	29	845.116
#76	REL	18	11	29	4334.734
#77	HOXA9	18	14	32	1434.867
#78	ETV5	18	12	30	3915.97
#79	NOTCH1	18	7	25	457.035
#80	ECSIT	18	8	26	1589.424
#81	AEBP1	18	11	29	2154.026
#82	IRF8	18	4	22	1400.09
#83	MYCL1	18	8	26	1541.271
#84	KLF9	18	11	29	1051.3
#85	LMO4	18	8	26	3939.017
#86	ZFHX4	18	8	26	1266.862
#87	VAV1	18	11	29	1893.873
#88	HOXD10	17	8	25	1528.703
#89	HMGB2	17	7	24	2704.653
#90	TGIF2	17	6	23	529.025
#91	SATB1	17	15	32	2882.605
#92	ZSCAN18	17	13	30	812.701
#93	TFAM	17	8	25	2136.401
#94	HMGA1	17	8	25	1225.67
#95	FLI1	17	10	27	2053.597
#96	POU5F1B	17	6	23	1391.113
#97	ZFPM2	17	5	22	319.563
#98	BACH1	17	13	30	3828.804
#99	EGR1	17	12	29	884.428
#100	VDR	17	7	24	925.746
#101	PTTG1	17	11	28	914.584
#102	TRIM22	17	10	27	1782.911
#103	C2orf3	16	8	24	1553.443
#104	ISL1	16	13	29	1275.466
#105	ETV4	16	11	27	1176.773
#106	SOX4	16	10	26	2634.989
#107	MLLT10	16	9	25	552.368
#108	JUNB	16	10	26	401.793
#109	TFEB	16	9	25	686.977
#110	BATF	16	5	21	494.201
#111	JUND	16	5	21	592.058
#112	HINFP	16	6	22	268.421
#113	SIX2	16	10	26	1006.101
#114	EGR2	15	13	28	2621.006
#115	ZIC3	15	10	25	953.214
#116	KLF5	15	17	32	3132.566
#117	CBFA2T3	15	8	23	681.961
#118	MEOX2	15	12	27	560.336
#119	KLF4	15	14	29	522.395
#120	CDKN2A	15	17	32	4217.568
#121	BCL3	15	16	31	933.826
#122	HOXA11	15	8	23	1035.438
#123	TP63	15	14	29	1336.399
#124	ST18	15	9	24	1451.15
#125	SOX9	15	12	27	995.16
#126	MYC	15	10	25	1324.353
#127	NFE2L3	14	13	27	1392.442
#128	NKX3-1	14	12	26	2231.682
#129	HMX1	14	13	27	2073.853
#130	MEIS2	14	14	28	1505.469
#131	DRAP1	14	9	23	831.996
#132	HOXD11	14	8	22	822.176
#133	E2F1	14	10	24	835.637
#134	FOXH1	14	8	22	467.533
#135	SOX13	14	9	23	1336.786
#136	NFATC4	14	8	22	218.323
#137	TP53	14	11	25	872.783
#138	NEUROD1	14	8	22	1277.345
#139	TFDP2	14	11	25	1997.868
#140	HIRA	14	13	27	630.21
#141	DBP	14	11	25	1151.263
#142	HOXB13	14	5	19	515.513
#143	NR0B1	14	9	23	2717.659
#144	TFAP2C	14	15	29	4240.183
#145	MMP14	13	11	24	610.308
#146	RUNX3	13	12	25	543.389
#147	PRDM1	13	9	22	2292.072
#148	CITED1	13	5	18	1069.648
#149	POU3F3	13	11	24	1038.58
#150	ZGPAT	13	11	24	3195.467
#151	DLX4	13	13	26	1221.085
#152	CEBPA	13	14	27	1407.112
#153	HOXD4	13	10	23	1578.487
#154	ZHX2	13	12	25	1431.787
#155	FUBP1	13	12	25	1018.037
#156	SOX15	13	7	20	467.553
#157	ERG	13	11	24	853.094
#158	JUN	13	7	20	382.056
#159	ESRRA	13	12	25	1559.103
#160	NR6A1	13	14	27	5283.795
#161	ZNF167	13	15	28	916.809
#162	TRPS1	13	14	27	1425.876
#163	MSC	13	11	24	3885.17
#164	PHF1	12	8	20	1185.735
#165	RB1	12	15	27	1512.24
#166	NFIB	12	13	25	918.548
#167	MEF2C	12	13	25	999.731
#168	MGA	12	7	19	2008.357
#169	E2F5	12	11	23	1173.3
#170	SMAD6	12	18	30	3348.981
#171	ZNF134	12	9	21	2461.215
#172	FOXM1	12	7	19	480.38
#173	MAFK	12	10	22	919.862
#174	TRIM29	12	8	20	1485.357
#175	ARNTL2	12	11	23	547.738
#176	ZNF268	12	13	25	921.512
#177	AR	12	13	25	1355.621
#178	TSC22D3	12	14	26	1845.575
#179	SP140	12	8	20	710.743
#180	STAT2	12	11	23	802.449
#181	DLX2	11	18	29	3489.096
#182	MSX2	11	11	22	819.159
#183	PITX2	11	19	30	2027.213
#184	HOXB7	11	12	23	941.309
#185	POU3F1	11	13	24	1493.443
#186	FOXA1	11	11	22	1440.348
#187	SCML2	11	8	19	699.44
#188	TFEC	11	3	14	39.204
#189	MSRB2	11	11	22	1038.815
#190	IKZF1	11	9	20	654.421
#191	STAT1	11	19	30	915.272
#192	TBX3	11	15	26	2073.628
#193	FOS	11	10	21	1490.652
#194	SLC26A3	11	10	21	1070.819
#195	CBFA2T2	11	13	24	1105.327
#196	FOXF2	11	8	19	423.086
#197	MBD1	11	10	21	2139.924
#198	BCL11B	11	17	28	1730.45
#199	GAS7	11	12	23	2385.938
#200	ZSCAN2	11	13	24	1163.516
#201	MZF1	11	14	25	1930.659
#202	ATF6	11	11	22	805.319
#203	FOXO3	10	13	23	1273.865
#204	ETS2	10	15	25	2035.063
#205	NFKB2	10	15	25	1365.043
#206	FOXC1	10	9	19	331.768
#207	HOXD13	10	9	19	1054.301
#208	SOX17	10	13	23	1795.05
#209	WNT5A	10	14	24	514.059
#210	GBX2	10	15	25	1419.862
#211	ZNF287	10	10	20	488.519
#212	EHF	10	10	20	1274.434
#213	MSX1	10	19	29	1705.575
#214	VTN	10	15	25	2274.015
#215	PPARG	10	12	22	978.329
#216	SOX2	10	16	26	849.348
#217	NANOG	10	8	18	442.971
#218	HOXB6	10	7	17	783.918
#219	STAT4	10	8	18	1176.714
#220	EN2	10	8	18	711.848
#221	POU6F1	10	18	28	2430.596
#222	ELF4	10	12	22	2601.072
#223	SIX5	10	10	20	3123.023
#224	RBPJ	10	10	20	504.119
#225	ZNF165	10	12	22	1005.346
#226	BTG2	10	12	22	1020.327
#227	VENTX	10	14	24	1644.349
#228	SOX11	10	16	26	1546.377
#229	SCAND2	10	15	25	2902.918
#230	NFIX	10	16	26	565.968
#231	ZHX3	10	8	18	307.47
#232	TBR1	9	9	18	2181.726
#233	HHEX	9	10	19	1276.616
#234	PKNOX2	9	10	19	1257.838
#235	NFE2	9	9	18	364.227
#236	HES1	9	14	23	1837.769
#237	FOXF1	9	11	20	735.452
#238	OLIG2	9	13	22	2349.397
#239	MEF2D	9	8	17	1241.155
#240	PAX5	9	7	16	877.212
#241	CUX2	9	7	16	460.462
#242	NFYA	9	13	22	1031.107
#243	IKZF3	9	13	22	5013.861
#244	FEV	9	9	18	2928.937
#245	ZNF202	9	11	20	688.91
#246	HOXB2	9	8	17	1012.239
#247	SALL1	9	13	22	1051.596
#248	ELK4	9	11	20	1044.907
#249	RORA	9	15	24	1087.322
#250	MLXIPL	9	10	19	2190.939
#251	HOXC10	9	15	24	2642.863
#252	HIC1	9	15	24	1215.681
#253	HOXC8	9	11	20	1723.042
#254	KLF6	9	12	21	1673.097
#255	TFAP2A	9	17	26	2275.694
#256	ZNF3	9	10	19	695.071
#257	HOXA3	8	9	17	2989.514
#258	PBX1	8	13	21	1158.952
#259	ETV1	8	16	24	1191.83
#260	EN1	8	14	22	1481.938
#261	MNX1	8	14	22	436.324
#262	SIX1	8	9	17	2196.575
#263	OVOL1	8	7	15	282.705
#264	NPAS1	8	9	17	1094.124
#265	HOXD3	8	12	20	854.974
#266	PLSCR1	8	12	20	1520.939
#267	POU4F1	8	10	18	887.073
#268	LHX6	8	9	17	1040.087
#269	HOXC13	8	12	20	968.546
#270	NKX3-2	8	11	19	1290.616
#271	NFATC1	8	12	20	1352.35
#272	HOXA5	8	9	17	411.668
#273	TEAD1	8	10	18	192.689
#274	SPIB	8	5	13	116.209
#275	ATF3	8	14	22	1097.94
#276	ZNF238	8	11	19	1438.745
#277	TLX2	8	11	19	1271.559
#278	TSHZ2	8	13	21	1388.353
#279	TBX4	8	11	19	1092.869
#280	BACH2	8	9	17	717.918
#281	ARID3A	8	6	14	185.888
#282	ETV2	8	11	19	1477.275
#283	ZNF643	8	9	17	459.35
#284	EGR3	8	13	21	834.622
#285	LASS6	8	11	19	1183.638
#286	KLF1	8	11	19	1205.787
#287	HAND1	7	13	20	790.051
#288	CREBZF	7	13	20	1737.512
#289	ARNT	7	15	22	1173.853
#290	ASCL2	7	12	19	1001.401
#291	MLL	7	9	16	1040.764
#292	ZSCAN5A	7	9	16	597.543
#293	RARB	7	13	20	1989.782
#294	CEBPE	7	10	17	431.757
#295	ZNF323	7	15	22	1435.148
#296	RUNX2	7	15	22	1028.137
#297	ZNF154	7	15	22	1171.853
#298	ESRRG	7	12	19	2079.201
#299	ARNTL	7	12	19	958.115
#300	HOXC4	7	10	17	292.265
#301	HOPX	7	11	18	895.057
#302	ZFP37	7	14	21	770.79
#303	TBX21	7	7	14	1036.768
#304	ZNF157	7	9	16	480.865
#305	HNF1B	7	10	17	1373.853
#306	FOXG1	7	14	21	2014.575
#307	HEY1	7	9	16	660.909
#308	TFAP2B	7	18	25	1511.996
#309	BATF3	7	11	18	1292.164
#310	IRF7	7	8	15	565.968
#311	NPAT	7	17	24	2190.883
#312	RXRG	7	9	16	1979.063
#313	SPDEF	7	12	19	567.696
#314	GATA6	7	11	18	261.875
#315	GATA4	7	18	25	1499.863
#316	KLF12	7	13	20	3005.761
#317	ESR1	7	11	18	3780.644
#318	NKX2-1	7	11	18	427.777
#319	ZNF446	7	14	21	1342.928
#320	TCF7	7	10	17	1214.883
#321	PLAG1	7	12	19	1117.567
#322	WT1	7	10	17	1401.251
#323	BNC1	7	15	22	568.171
#324	TBX10	7	15	22	1367.42
#325	FOXC2	7	10	17	437.99
#326	FOXO1	7	13	20	470.707
#327	GATA3	7	18	25	557.522
#328	STRN3	7	8	15	217.373
#329	CRX	7	9	16	630.128
#330	ZBTB48	7	9	16	833.04
#331	MEOX1	7	12	19	1323.58
#332	ATF6B	6	12	18	1200.233
#333	PITX1	6	18	24	1256.267
#334	IRF5	6	8	14	248.251
#335	SPI1	6	12	18	778.377
#336	STAT5A	6	13	19	607.525
#337	SOX30	6	9	15	253.872
#338	NR4A3	6	10	16	402.711
#339	HIF3A	6	11	17	742.604
#340	LZTS1	6	7	13	537.726
#341	TAF13	6	10	16	458.976
#342	ALX1	6	9	15	583.841
#343	ZNF117	6	12	18	569.889
#344	ZNF93	6	12	18	1612.186
#345	HNF1A	6	11	17	1229.19
#346	NFIC	6	14	20	288.124
#347	TBX2	6	15	21	418.958
#348	SOX10	6	10	16	1358.47
#349	HOXB3	6	13	19	1074.412
#350	ZNF155	6	11	17	850.794
#351	PGR	6	10	16	184.476
#352	BHLHE41	6	13	19	924.713
#353	HOXA7	6	12	18	334.485
#354	FOXA2	6	11	17	929.031
#355	HOXA1	6	11	17	2596.321
#356	NR1H4	6	7	13	1143.836
#357	ZNF41	6	7	13	414.035
#358	ZNF174	6	17	23	633.539
#359	TCF21	6	15	21	997.068
#360	GSC2	6	12	18	739.51
#361	SOX18	6	10	16	919.01
#362	SOX5	6	12	18	1504.736
#363	FOXD2	6	14	20	938.524
#364	RBPJL	6	8	14	771.614
#365	MXD1	6	14	20	1531.282
#366	FOSB	6	12	18	564.684
#367	EGR4	6	13	19	919.668
#368	HOXD9	6	7	13	2103.918
#369	TBX5	6	10	16	2820.11
#370	LEF1	6	17	23	990.954
#371	NKX2-5	5	15	20	763.623
#372	POU4F3	5	12	17	2959.992
#373	SRY	5	14	19	1004.245
#374	CREB5	5	14	19	945.262
#375	HOXC5	5	16	21	838.416
#376	NR2C1	5	10	15	133.487
#377	PHOX2B	5	15	20	1377.714
#378	HNF4G	5	11	16	495.275
#379	POU6F2	5	13	18	1663.247
#380	PAX6	5	9	14	835.731
#381	NFAT5	5	9	14	1141.336
#382	HMG20B	5	12	17	521.171
#383	KDM5B	5	8	13	1215.419
#384	FOXE1	5	16	21	1092.367
#385	NEUROG1	5	15	20	2009.624
#386	NKX6-1	5	9	14	1648.684
#387	RUNX1T1	5	11	16	210.425
#388	CSRNP3	5	10	15	2064.339
#389	HLF	5	13	18	1630.528
#390	SIM2	5	15	20	545.403
#391	ZNF80	5	11	16	948.983
#392	HESX1	5	11	16	1624.875
#393	TCF15	5	10	15	2620.04
#394	ZNF277	5	9	14	973.27
#395	RFXAP	5	13	18	447.511
#396	TLX3	5	14	19	1467.916
#397	SMAD9	5	12	17	741.947
#398	NR5A2	5	13	18	945.945
#399	RERE	5	11	16	607.789
#400	SNAPC5	5	13	18	1255.833
#401	NR5A1	5	5	10	737.273
#402	DLX6	5	11	16	1473.472
#403	CREBBP	5	9	14	1436.945
#404	TSC22D2	5	15	20	765.242
#405	MYT1L	5	10	15	1076.239
#406	TCF7L2	5	21	26	1631.795
#407	MYOD1	5	12	17	395.895
#408	POU2F2	5	9	14	446.529
#409	NR3C2	5	14	19	444.656
#410	SIX3	5	11	16	1434.016
#411	ASCL1	5	18	23	1312.236
#412	FOXD3	5	11	16	1036.391
#413	E2F2	5	14	19	1201.179
#414	ZNF81	4	14	18	1247.817
#415	TCF12	4	13	17	1371.732
#416	NR4A2	4	15	19	318.707
#417	MYF6	4	10	14	659.612
#418	PRDM2	4	16	20	1446.834
#419	NR4A1	4	13	17	562.157
#420	FOXB1	4	11	15	1071.676
#421	ATOH1	4	14	18	529.023
#422	DMRT1	4	13	17	2151.743
#423	BARX1	4	13	17	1143.017
#424	GATA2	4	12	16	232.344
#425	MYF5	4	14	18	1037.521
#426	TEF	4	11	15	1128.135
#427	MTA2	4	19	23	1547.314
#428	HOXB8	4	10	14	464.726
#429	SIM1	4	12	16	1066.902
#430	KLF15	4	11	15	1137.385
#431	RORB	4	9	13	216.064
#432	HNF4A	4	9	13	616.02
#433	PROX1	4	14	18	1590.562
#434	LHX5	4	11	15	767.767
#435	SATB2	4	15	19	606.511
#436	FOXI1	4	11	15	293.112
#437	POU3F4	4	12	16	1804.758
#438	ZNF444	4	12	16	959.51
#439	ZIC1	4	15	19	1147.072
#440	MECOM	4	16	20	499.396
#441	GLI2	4	8	12	162.934
#442	TADA2A	4	11	15	538.503
#443	PAX3	4	13	17	979.448
#444	GTF2H3	4	16	20	689.579
#445	NRL	4	11	15	402.134
#446	FOXE3	4	10	14	404.46
#447	MYT1	4	12	16	1293.892
#448	EMX1	3	14	17	2041.734
#449	ZSCAN16	3	11	14	2031.439
#450	YY1	3	11	14	3262.369
#451	FOXO4	3	10	13	454.023
#452	PDX1	3	12	15	399.787
#453	TBX1	3	12	15	556.707
#454	LHX2	3	13	16	330.539
#455	ZNF215	3	10	13	186.514
#456	POU1F1	3	8	11	1119.601
#457	GCM1	3	10	13	406.592
#458	LHX1	3	10	13	965.178
#459	RARA	3	9	12	82.865
#460	MAFB	3	15	18	458.306
#461	RARG	3	8	11	294.066
#462	ZNF236	3	11	14	573.034
#463	CREM	3	17	20	770.179
#464	HOXA2	3	9	12	626.986
#465	ZNF500	3	11	14	517.709
#466	BRD8	3	9	12	395.931
#467	SMAD1	3	16	19	821.297
#468	ELF5	3	14	17	811.827
#469	BLZF1	3	9	12	275.551
#470	ESR2	3	10	13	354.476
#471	ZSCAN12	3	6	9	221.801
#472	FOXJ1	2	10	12	1674.145
#473	ALX3	2	13	15	772.185
#474	VSX1	2	12	14	359.718
#475	ATF5	2	13	15	275.784
#476	TBX6	2	10	12	209.267
#477	NR1I2	2	11	13	360.945
#478	TBX19	2	8	10	585.625
#479	FOXP3	2	15	17	296.868
#480	ZNF639	2	13	15	322.928
#481	IRX4	2	14	16	968.688
#482	MSL3	2	6	8	43.733
#483	HEY2	2	19	21	589.256
#484	IRF4	2	14	16	325.696
#485	ONECUT1	2	6	8	730.897
#486	NKX2-8	2	18	20	1562.403
#487	SCRT1	2	9	11	622.467
#488	NFX1	2	13	15	165.633
#489	HOXB1	2	12	14	182.597
#490	TAL1	2	14	16	352.807
#491	ZFHX3	2	13	15	338.264
#492	POU2F3	1	11	12	34.24
#493	PPARD	1	13	14	399.237
#494	PKNOX1	1	16	17	85.735
#495	HAND2	1	13	14	201.948
#496	PTH	1	14	15	272.593
#497	PAX8	1	16	17	178.04
#498	ZNF135	1	11	12	22.971
#499	C11orf9	1	9	10	433.742
#500	REST	0	10	10	0