Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	TCF4	51	1	52	50.243
#2	ZEB2	43	2	45	1330.969
#3	FOXM1	42	2	44	134.589
#4	FOXN3	42	7	49	803.448
#5	FOXA1	42	0	42	0
#6	EPAS1	39	10	49	529.718
#7	RUNX1T1	39	5	44	6187.488
#8	HNF1B	38	1	39	24.31
#9	RORA	38	9	47	3243.761
#10	ZEB1	37	3	40	764.844
#11	SPDEF	36	6	42	720.472
#12	TBX2	36	4	40	266.538
#13	NOLC1	36	9	45	4768.999
#14	AR	35	7	42	4264.019
#15	PRRX2	35	10	45	1376.629
#16	YEATS4	34	8	42	7608.578
#17	TWIST1	34	8	42	3468.782
#18	MEF2C	33	2	35	32.309
#19	JUN	33	8	41	948.048
#20	CDKN2A	32	8	40	2399.8
#21	PHF1	32	5	37	556.474
#22	TFDP1	31	7	38	1184.98
#23	CNOT8	31	6	37	699.022
#24	KLF2	30	8	38	3301.381
#25	TFAP2A	30	5	35	1521.162
#26	HIF3A	29	2	31	561.883
#27	ADNP	29	8	37	796.243
#28	MYBL2	29	6	35	391.965
#29	PTTG1	29	5	34	1097.924
#30	E2F4	29	5	34	1893.294
#31	XBP1	29	7	36	735.2
#32	FEV	29	3	32	1788.562
#33	MECOM	29	5	34	494.59
#34	FOXG1	29	13	42	3280.395
#35	HNRNPK	29	5	34	692.616
#36	ELK3	28	3	31	1128.51
#37	MZF1	28	9	37	1103.862
#38	MEIS2	28	10	38	483.941
#39	ZNF236	28	6	34	388.81
#40	GAS7	27	7	34	867.961
#41	ERG	27	4	31	874.742
#42	ATF2	27	7	34	743.118
#43	SIM2	27	3	30	89.55
#44	TCF25	26	6	32	2342.268
#45	SOX17	26	7	33	2882.028
#46	E2F3	26	9	35	1091.659
#47	ATF1	26	9	35	533.937
#48	HMGA1	26	11	37	4213.619
#49	FLI1	25	8	33	1883.698
#50	CREBZF	25	11	36	2479.701
#51	EN1	24	4	28	1126.712
#52	RFXANK	24	11	35	2740.531
#53	YBX1	24	9	33	531.135
#54	ETS2	24	10	34	913.406
#55	MITF	24	7	31	2037.209
#56	TFAM	24	7	31	499.245
#57	KLF9	23	14	37	961.532
#58	PBX1	23	9	32	1999.762
#59	NR2F6	23	10	33	838.635
#60	GATA3	23	4	27	171.436
#61	TCF7L1	23	14	37	1067.475
#62	HNRNPAB	22	8	30	540.82
#63	E2F5	22	14	36	2811.709
#64	KLF7	22	11	33	1340.72
#65	HOXC8	22	8	30	6753.11
#66	RBPJ	22	9	31	1270.243
#67	ZNF45	22	13	35	2299.378
#68	PRDM2	22	11	33	964.118
#69	PURA	22	10	32	1338.505
#70	MEOX1	22	8	30	677.65
#71	IRF8	22	10	32	595.435
#72	MSX1	21	8	29	422.284
#73	EGR1	21	7	28	219.844
#74	FOXC1	21	12	33	1595.081
#75	PRDM1	21	6	27	370.306
#76	TEAD4	21	6	27	199.324
#77	ESR1	21	17	38	3208.298
#78	RFX5	21	12	33	1700.862
#79	LASS6	20	11	31	1803.728
#80	GTF2H3	20	6	26	496.055
#81	FOXA2	20	4	24	3617.282
#82	TRIM22	20	9	29	616.444
#83	KDM5B	20	11	31	2615.463
#84	LMO4	20	15	35	2237.497
#85	NR3C1	20	10	30	677.569
#86	ZNF24	20	13	33	1805.53
#87	GRHL2	20	11	31	2883.566
#88	SPIB	20	6	26	1698.028
#89	ELK1	20	5	25	1812.996
#90	NR1I2	20	4	24	56.799
#91	HCLS1	20	1	21	138.073
#92	PEG3	20	19	39	13859.996
#93	ZFPM2	20	3	23	18.796
#94	ZNF3	19	8	27	861.294
#95	HOXC11	19	12	31	2463.793
#96	FOXO1	19	6	25	1011.107
#97	BRD8	19	8	27	1343.523
#98	ELF1	19	10	29	777.213
#99	AHR	18	11	29	349.889
#100	SP140	18	6	24	1991.392
#101	IRX5	18	14	32	1236.776
#102	MAF	18	14	32	1841.622
#103	MEOX2	18	12	30	389.229
#104	TRIM28	18	16	34	1391.817
#105	GTF2H4	18	14	32	2153.555
#106	STAT1	18	6	24	1280.086
#107	REST	18	7	25	559.671
#108	KLF10	18	10	28	956.952
#109	ZSCAN12	17	6	23	5991.33
#110	AEBP1	17	10	27	4374.456
#111	ARNT2	17	12	29	1492.119
#112	LZTR1	17	8	25	935.464
#113	KLF6	17	9	26	1668.737
#114	UBN1	17	9	26	1998.027
#115	E2F8	17	7	24	4047.153
#116	BHLHE40	17	15	32	1620.526
#117	JUND	17	12	29	1297.775
#118	BACH1	17	9	26	1998.396
#119	ALX1	17	8	25	2091.605
#120	ARNTL2	17	8	25	1080.384
#121	NOTCH1	17	10	27	731.964
#122	FOS	17	10	27	710.281
#123	ZFHX4	17	11	28	1449.854
#124	EDF1	16	7	23	239.199
#125	CREB3L1	16	11	27	945.928
#126	TFDP2	16	13	29	1294.449
#127	HOXD10	16	5	21	682.977
#128	ELF4	16	6	22	449.454
#129	RERE	16	14	30	1260.625
#130	USF2	16	6	22	398.902
#131	DLX2	16	6	22	629.558
#132	PITX1	16	17	33	1231.906
#133	KLF11	16	10	26	1118.344
#134	NR5A2	16	3	19	42.688
#135	SOX10	16	11	27	1247.901
#136	SCAND1	15	9	24	832.911
#137	STRN3	15	12	27	1287.636
#138	CNBP	15	13	28	1098.329
#139	TCEAL1	15	10	25	1482.998
#140	NFKB2	15	7	22	995.638
#141	CEBPD	15	16	31	2160.466
#142	TCF7	15	10	25	758.418
#143	SOX9	15	13	28	1772.772
#144	TBX3	15	14	29	1030.579
#145	TLX3	15	8	23	2538.597
#146	GTF2IRD1	15	10	25	1204.783
#147	ZNF238	15	19	34	6929.178
#148	ZNF500	15	11	26	1881.979
#149	NFYB	15	8	23	544.655
#150	HDAC2	15	15	30	1121.744
#151	MYNN	15	10	25	330.074
#152	ZNF131	15	12	27	1315.596
#153	HHEX	15	8	23	272.939
#154	ZNF91	15	9	24	513.121
#155	LASS2	14	15	29	2111.844
#156	ECSIT	14	8	22	1000.155
#157	NFATC3	14	14	28	1490.397
#158	BUD31	14	17	31	2574.498
#159	NR3C2	14	15	29	1177.265
#160	SNAI2	14	11	25	149.849
#161	MYCN	14	9	23	1153.855
#162	DRAP1	14	11	25	1589.87
#163	PKNOX2	14	9	23	2308.12
#164	TCF12	14	11	25	1787.984
#165	KDM5A	14	13	27	1752.71
#166	HOXA5	14	10	24	7214.5
#167	SOX21	14	7	21	49.993
#168	AFF1	14	13	27	2121.988
#169	NFYA	14	9	23	1282.42
#170	TFAP2C	14	12	26	617.095
#171	HSF2	14	11	25	1010.44
#172	CREB5	14	10	24	1291.084
#173	TSC22D3	14	7	21	456.418
#174	ATF3	14	5	19	205.717
#175	KLF3	13	6	19	131.433
#176	TBX19	13	12	25	1025.627
#177	ZBTB25	13	10	23	311.725
#178	ZNF83	13	13	26	1043.808
#179	NR4A1	13	7	20	1546.305
#180	SLC30A9	13	14	27	1733.103
#181	MSL3	13	13	26	2087.479
#182	HOXD4	13	8	21	152.345
#183	STAT5B	13	7	20	792.258
#184	LHX3	13	9	22	875.888
#185	SOX4	13	10	23	636.776
#186	TAF4	13	10	23	761.388
#187	E4F1	13	10	23	1120.52
#188	VAV1	13	4	17	1088.475
#189	BCL6	13	16	29	1950.883
#190	RCOR1	13	13	26	686.642
#191	RARA	13	10	23	686.747
#192	ZSCAN16	13	13	26	1559.67
#193	HOXC10	13	15	28	1676.83
#194	HOXA9	12	19	31	1010.866
#195	ELF5	12	15	27	2832.529
#196	CIR1	12	8	20	780.92
#197	ESRRG	12	17	29	1970.78
#198	ZNF207	12	10	22	874.732
#199	HOXB2	12	17	29	1385.247
#200	FOSB	12	6	18	183.578
#201	PKNOX1	12	14	26	1337.199
#202	ARID4A	12	10	22	236.05
#203	IRF1	12	14	26	2218.612
#204	CNOT7	12	13	25	1230.613
#205	MSRB2	12	18	30	1478.053
#206	CLOCK	12	8	20	1150.052
#207	CREBL2	12	12	24	1575.779
#208	SATB1	12	19	31	5605.941
#209	STAT4	12	12	24	1185.314
#210	NFYC	12	16	28	2804.502
#211	KLF12	12	15	27	575.769
#212	ZBTB38	12	15	27	1848.299
#213	SUPT4H1	12	9	21	774.351
#214	POU6F1	12	13	25	409.063
#215	NFIL3	12	11	23	855.387
#216	HOXD3	11	15	26	1121.536
#217	NKX3-1	11	16	27	2486.061
#218	TFEC	11	11	22	1666.09
#219	MYC	11	21	32	1712.439
#220	ZNF165	11	18	29	1404.597
#221	NR1H3	11	10	21	789.574
#222	MAFB	11	12	23	929.224
#223	PPARG	11	12	23	1118.966
#224	CSDA	11	13	24	606.129
#225	TSHZ2	11	16	27	744.543
#226	JUNB	11	7	18	1673.916
#227	HMGB2	11	10	21	664.561
#228	HIF1A	11	16	27	1148.328
#229	ZNF132	11	4	15	517.741
#230	MLX	11	13	24	449.968
#231	PGR	11	13	24	1032.64
#232	TCF3	11	12	23	898.528
#233	SMAD1	11	16	27	863.559
#234	MYCL1	11	16	27	2400.236
#235	TAF5	11	16	27	1811.085
#236	NFIB	11	19	30	2531.51
#237	SMAD4	11	14	25	636.897
#238	ZNF133	11	11	22	1106.528
#239	SP3	11	14	25	626.811
#240	MLL	11	7	18	558.889
#241	ZNF148	11	12	23	1819.389
#242	RNF4	11	9	20	399.588
#243	ELF3	10	14	24	1436.201
#244	ZBTB48	10	14	24	993.438
#245	BHLHE41	10	21	31	1612.469
#246	NR2C1	10	12	22	1371.069
#247	MGA	10	15	25	1960.656
#248	HOXD9	10	12	22	620.21
#249	ZNF75D	10	19	29	1617.204
#250	STAT5A	10	9	19	739.203
#251	ZNF268	10	14	24	1470.063
#252	CREB3L2	10	12	22	1538.54
#253	NFIC	10	13	23	1399.04
#254	IRF5	10	14	24	453.708
#255	TFEB	10	15	25	1167.281
#256	ETV1	10	13	23	727.519
#257	SMAD2	10	15	25	2210.653
#258	ZNF33B	10	6	16	1219.381
#259	FOXO3	10	13	23	983.002
#260	ZNF135	10	12	22	1878.824
#261	CTCF	10	8	18	543.1
#262	SLC2A4RG	10	16	26	902.72
#263	EGR2	10	10	20	1869.918
#264	HMBOX1	10	13	23	389.702
#265	AATF	10	15	25	918.937
#266	ZBTB17	10	10	20	524.399
#267	HOXB5	10	9	19	1066.098
#268	FOXD1	10	10	20	989.388
#269	SLC26A3	10	7	17	1002.055
#270	TAL1	10	8	18	58.334
#271	TAF7	10	21	31	1923.68
#272	ARNT	10	8	18	758.776
#273	TCF15	10	9	19	466.863
#274	TCF20	10	12	22	1760.784
#275	GLI2	10	8	18	295.801
#276	YY1	10	16	26	1344.406
#277	ZNF217	10	13	23	792.684
#278	ZSCAN18	9	13	22	2336.235
#279	PAX6	9	11	20	2614.389
#280	SALL2	9	13	22	715.658
#281	TARDBP	9	15	24	2546.04
#282	MAFF	9	12	21	435.039
#283	EHF	9	20	29	2944.708
#284	NR2F2	9	13	22	1124.36
#285	NEUROD2	9	10	19	2338.337
#286	IRF7	9	10	19	637.718
#287	ZFP36L1	9	17	26	1506.292
#288	FOXF2	9	15	24	1823.882
#289	TP53	9	17	26	9680.986
#290	TBX5	9	12	21	947.788
#291	SOX11	9	19	28	3258.074
#292	DMTF1	9	11	20	500.271
#293	ZKSCAN1	9	17	26	1153.992
#294	TAF10	9	7	16	783.822
#295	MYT1	9	5	14	1162.93
#296	HOXB6	9	13	22	3973.676
#297	EGR3	9	16	25	2604.624
#298	TRPS1	9	16	25	667.656
#299	TSC22D1	9	19	28	1341.862
#300	C2orf3	9	17	26	968.054
#301	ZNF281	9	17	26	1082.276
#302	TCFL5	9	16	25	965.622
#303	MEIS1	9	20	29	906.117
#304	MMP14	9	11	20	1048.457
#305	ASCL1	9	6	15	1528.763
#306	DDIT3	9	16	25	2668.402
#307	CUX1	9	14	23	1283.479
#308	NFE2L1	9	18	27	3794.657
#309	PLAG1	8	12	20	1130.976
#310	E2F1	8	8	16	215.917
#311	FOXJ3	8	17	25	1108.745
#312	SIX3	8	16	24	1399.543
#313	PLSCR1	8	13	21	1472.15
#314	GATAD1	8	16	24	525.831
#315	PBX3	8	19	27	2406.538
#316	ZNF444	8	13	21	1973.168
#317	BTG2	8	15	23	1142.176
#318	TBP	8	13	21	922.921
#319	NR4A3	8	11	19	2667.342
#320	NFATC4	8	19	27	976.35
#321	MEF2A	8	17	25	669.17
#322	GABPB1	8	17	25	972.979
#323	RXRA	8	14	22	958.162
#324	NFKB1	8	16	24	965.279
#325	NFE2L3	8	12	20	1128.671
#326	KLF4	8	12	20	387.287
#327	IRF3	8	14	22	884.067
#328	TFAP2B	8	17	25	1326.853
#329	TFCP2	8	15	23	1422.608
#330	TGIF2	8	12	20	1409.633
#331	ENO1	8	21	29	957.587
#332	MSX2	7	12	19	1158.872
#333	CEBPA	7	13	20	1042.295
#334	SMAD3	7	17	24	1524.199
#335	ZNF167	7	20	27	1656.078
#336	SPEN	7	12	19	442.069
#337	NFATC1	7	16	23	1052.207
#338	CTNNB1	7	18	25	1702.123
#339	MEIS3P1	7	17	24	871.038
#340	MAFG	7	14	21	1666.965
#341	ZNF277	7	18	25	2522.06
#342	MBD1	7	13	20	847.85
#343	CBFA2T3	7	11	18	1365.286
#344	PCGF2	7	16	23	759.497
#345	ZHX3	7	14	21	1496.297
#346	MTA1	7	17	24	1243.021
#347	SCML1	7	17	24	1402.882
#348	IRF6	7	16	23	778.497
#349	TFCP2L1	7	16	23	815.435
#350	NFE2L2	7	13	20	3246.947
#351	HSF1	7	15	22	1218.74
#352	PBX2	7	13	20	1547.196
#353	FOXJ2	7	12	19	963.679
#354	CEBPB	7	17	24	852.587
#355	SATB2	7	16	23	491.346
#356	GATAD2A	7	13	20	775.597
#357	HEY1	7	23	30	2242.546
#358	E2F6	7	16	23	688.911
#359	STAT6	7	16	23	1527.9
#360	ELF2	7	18	25	1096.566
#361	HMG20A	7	17	24	1693.645
#362	CREBBP	7	12	19	939.809
#363	ATF6B	7	9	16	458.778
#364	ZNF202	7	9	16	825.373
#365	BATF3	7	10	17	667.458
#366	NR4A2	7	11	18	452.828
#367	FOXO4	7	14	21	475.43
#368	TADA3	7	13	20	652.757
#369	LHX6	7	13	20	228.595
#370	SRF	7	16	23	1255.636
#371	HMG20B	7	17	24	2876.09
#372	SNAPC5	6	13	19	798.046
#373	THRA	6	13	19	374.79
#374	RUNX1	6	19	25	1619.709
#375	LEF1	6	26	32	5286.914
#376	SOX13	6	16	22	1061.337
#377	MAX	6	12	18	536.026
#378	ZNF394	6	16	22	1458.097
#379	SOX12	6	13	19	609.618
#380	C11orf9	6	14	20	908.998
#381	MLXIPL	6	11	17	1422.752
#382	RBCK1	6	17	23	4329.587
#383	HOXA10	6	11	17	4422.604
#384	CSRNP2	6	13	19	516.433
#385	TBX10	6	13	19	4804.769
#386	NR0B1	6	9	15	345.757
#387	NR2F1	6	19	25	1580.485
#388	RUNX3	6	13	19	798.629
#389	RARB	6	18	24	1181.587
#390	CBFB	6	16	22	1695.774
#391	SOX15	6	12	18	529.643
#392	HOXC4	6	19	25	802.089
#393	MNT	6	14	20	531.77
#394	ZNF263	6	15	21	1300.897
#395	ZNF434	6	16	22	775.709
#396	GATA2	6	17	23	1439.684
#397	ZHX2	6	15	21	1847.694
#398	MNX1	6	14	20	697.835
#399	STAT3	5	15	20	972.464
#400	SUPT6H	5	11	16	1021.37
#401	IKZF1	5	12	17	1216.873
#402	HOPX	5	11	16	1430.582
#403	NFAT5	5	16	21	347.761
#404	BACH2	5	13	18	820.139
#405	ZNF215	5	14	19	603.218
#406	HOXB7	5	11	16	769.082
#407	ZNF117	5	15	20	424.159
#408	ATF4	5	17	22	1240.268
#409	FOXF1	5	14	19	3204.864
#410	BTAF1	5	21	26	2899.508
#411	IRF4	5	12	17	966.271
#412	CTBP1	5	19	24	724.992
#413	HOXA1	5	13	18	516.528
#414	ZNF93	5	17	22	2156.251
#415	PLAGL2	5	17	22	884.621
#416	PHTF1	5	11	16	723.877
#417	NANOG	5	12	17	300.704
#418	CREB1	5	14	19	1179.925
#419	HR	5	17	22	882.124
#420	HES1	5	18	23	294.499
#421	POU2F3	5	14	19	726.517
#422	CREM	5	9	14	149.288
#423	HMGB1	5	18	23	824.578
#424	WT1	5	17	22	958.962
#425	LZTS1	5	11	16	243.044
#426	RELB	5	11	16	266.538
#427	NFIX	5	20	25	1259.674
#428	ZNF323	4	19	23	1215.887
#429	RCAN1	4	20	24	518.359
#430	TRIM29	4	18	22	619.379
#431	KLF5	4	18	22	494.198
#432	HIRA	4	20	24	1337.981
#433	TCF7L2	4	18	22	682.736
#434	SREBF1	4	15	19	178.443
#435	ZNF232	4	18	22	401.486
#436	SIX2	4	13	17	897.792
#437	FOXK2	4	17	21	1635.25
#438	FBXW7	4	19	23	1057.499
#439	ATF5	4	21	25	544.604
#440	IRF9	4	15	19	1878.857
#441	NR1D2	4	19	23	1023.012
#442	ETV5	4	19	23	1165.732
#443	ADNP2	4	17	21	536.111
#444	IRX4	4	11	15	258.639
#445	SIM1	4	14	18	932.635
#446	NCOR1	4	22	26	1610.328
#447	SMAD6	4	10	14	101.107
#448	TFE3	4	19	23	821.582
#449	SCML2	4	18	22	729.342
#450	SIX1	4	16	20	767.774
#451	PRRX1	4	11	15	492.367
#452	TAF6	4	14	18	264.705
#453	SP4	4	13	17	154.572
#454	NPAS2	3	19	22	542.215
#455	ATF6	3	18	21	1321.078
#456	NFX1	3	17	20	426.151
#457	ZIC1	3	20	23	686.767
#458	AHCTF1	3	17	20	464.652
#459	BATF	3	17	20	743.747
#460	IRF2	3	14	17	401.485
#461	RB1	3	23	26	424.351
#462	VDR	3	21	24	608.026
#463	TULP4	3	11	14	131.765
#464	BCL11B	3	19	22	789.009
#465	ARNTL	3	20	23	342.125
#466	EGR4	3	15	18	210.902
#467	GCFC1	3	16	19	433.21
#468	ZNF193	3	14	17	1525.281
#469	TP63	3	20	23	482.945
#470	ETV7	3	16	19	613.109
#471	ZGPAT	3	18	21	506.501
#472	TSC22D2	3	20	23	810.846
#473	GATA6	3	15	18	856.59
#474	PPARD	2	11	13	189.811
#475	SREBF2	2	13	15	484.302
#476	MLLT10	2	13	15	297.745
#477	ZXDC	2	15	17	313.701
#478	ZNF174	2	14	16	136.646
#479	NPAT	2	16	18	364.48
#480	ZNF274	2	21	23	395.974
#481	HDAC1	2	18	20	452.968
#482	HLF	2	14	16	423.533
#483	TEAD1	2	10	12	120.179
#484	HEY2	2	16	18	171.807
#485	TGIF1	2	18	20	957.009
#486	ZFP36L2	2	15	17	211.964
#487	CITED2	2	20	22	1633.338
#488	FOSL2	2	15	17	505.508
#489	HOXD1	2	14	16	158.845
#490	CITED1	2	21	23	898.285
#491	ZNF189	2	13	15	456.058
#492	NKX3-2	1	13	14	110.799
#493	UBP1	1	17	18	29.822
#494	BCL3	1	17	18	66.759
#495	PA2G4	1	16	17	326.414
#496	FUBP1	1	28	29	651.028
#497	WNT5A	1	23	24	313.252
#498	CBFA2T2	1	11	12	254.785
#499	CUX2	0	8	8	0
#500	GLI3	0	19	19	0