Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	IKZF1	46	3	49	998.884
#2	MITF	41	4	45	407.835
#3	ZFP36L1	38	8	46	1776.898
#4	ELF3	35	8	43	1257.988
#5	CBFA2T3	35	3	38	676.239
#6	IRF4	32	3	35	2548.976
#7	ETV5	31	9	40	764.625
#8	RXRG	30	5	35	212.969
#9	CTCF	30	4	34	1107.787
#10	JUN	30	9	39	1024.668
#11	FOSL1	28	10	38	1013.537
#12	STAT5A	28	3	31	225.093
#13	ARNT2	27	9	36	2018.199
#14	ELF1	27	12	39	2939.805
#15	TSC22D2	27	10	37	1145.789
#16	GAS7	27	8	35	888.243
#17	ESRRA	27	9	36	1602.193
#18	SOX10	26	1	27	160.532
#19	LEF1	26	11	37	838.288
#20	ELK3	26	16	42	2582.675
#21	TBX2	26	5	31	472.952
#22	SNAI2	26	12	38	1750.278
#23	EN1	25	7	32	1250.882
#24	MAFF	25	14	39	857.704
#25	LZTS1	25	4	29	231.032
#26	TAL1	25	3	28	268.684
#27	ZEB2	25	9	34	1692.853
#28	IRF6	24	2	26	383.692
#29	ZBTB38	24	11	35	2055.241
#30	PCGF2	24	8	32	1100.05
#31	CREB1	24	9	33	1066.249
#32	TAF4B	24	4	28	734.444
#33	HOXA5	24	6	30	1438.152
#34	NFATC3	24	7	31	977.839
#35	TAF5	23	4	27	229.873
#36	SOX15	23	1	24	68.647
#37	GRHL2	23	3	26	602.353
#38	HCLS1	23	5	28	964.638
#39	NFE2	23	8	31	820.504
#40	TFE3	22	13	35	2042.659
#41	NR1H3	22	16	38	2716.68
#42	TEAD1	22	9	31	1217.985
#43	FUBP1	22	12	34	1574.714
#44	TCF15	22	6	28	490.087
#45	TAF4	22	11	33	1128.706
#46	TCF20	22	7	29	955.329
#47	BATF	22	9	31	1367.33
#48	HEY1	22	8	30	922.827
#49	ZKSCAN1	21	11	32	1376.004
#50	HMGB1	21	8	29	1139.674
#51	HNF1B	21	6	27	459.617
#52	ELF2	21	11	32	1939.898
#53	E2F8	21	10	31	1323.044
#54	HMG20A	21	9	30	2482.494
#55	CITED1	21	3	24	20.518
#56	ZNF394	21	17	38	2963.539
#57	SPDEF	21	6	27	1524.853
#58	NFIL3	21	9	30	990.407
#59	DBP	21	7	28	692.95
#60	MLXIPL	21	4	25	1253.538
#61	ALX1	21	9	30	1004.654
#62	SPI1	20	9	29	868.394
#63	KLF5	20	10	30	1008.308
#64	NPAT	20	9	29	1300.835
#65	FOSL2	20	10	30	829.152
#66	CDX2	20	6	26	2352.508
#67	MYC	20	15	35	1716.99
#68	NR4A3	19	8	27	234.018
#69	SMAD3	19	11	30	780.129
#70	ATF1	19	8	27	1087.229
#71	GBX2	19	4	23	569.057
#72	STAT5B	19	9	28	1522.895
#73	MGA	19	10	29	1055.019
#74	ZEB1	19	17	36	1678.065
#75	HOXB5	19	11	30	1502.33
#76	MMP14	18	9	27	950.954
#77	CEBPA	18	11	29	1341.766
#78	TGIF2	18	10	28	1013.191
#79	TBP	18	11	29	752.934
#80	NR3C1	18	12	30	1443.194
#81	KLF7	18	11	29	1232.412
#82	CSRNP2	18	11	29	1938.64
#83	HSF2	18	4	22	844.34
#84	VAV1	18	5	23	490.4
#85	ZNF165	18	9	27	604.567
#86	MEIS3P1	18	11	29	1425.479
#87	FOXN3	18	12	30	2091.612
#88	KLF10	18	12	30	2137.509
#89	SOX13	18	13	31	1609.637
#90	PRRX1	18	12	30	1714.527
#91	RB1	17	20	37	2694.107
#92	NFAT5	17	9	26	1077.503
#93	ATF2	17	9	26	1122.942
#94	MLL	17	11	28	1434.692
#95	SP3	17	4	21	805.052
#96	ADNP	17	11	28	988.151
#97	CNOT8	17	10	27	1025.296
#98	PPARG	17	10	27	690.819
#99	RCOR1	17	9	26	919.089
#100	HMX1	17	3	20	139.652
#101	E4F1	17	11	28	1434.659
#102	GCFC1	17	13	30	2107.141
#103	FOXO4	17	4	21	366.073
#104	ELF5	17	2	19	242.737
#105	KLF9	17	8	25	299.992
#106	TWIST1	17	9	26	834.033
#107	ZFHX3	17	8	25	1008.379
#108	TCF7	17	2	19	98.488
#109	ETV4	17	13	30	1374.976
#110	STAT1	16	12	28	1242.669
#111	FOXG1	16	14	30	1719.94
#112	ARNTL2	16	20	36	2534.565
#113	SCML1	16	11	27	1035.851
#114	BCL11B	16	7	23	1063.886
#115	EHF	16	4	20	144.19
#116	NPAS2	16	13	29	879.174
#117	RBCK1	16	10	26	1185.945
#118	TRIM29	16	12	28	1161.846
#119	RELB	16	10	26	977.203
#120	MNX1	16	9	25	1151.767
#121	ZNF45	16	15	31	1522.132
#122	HOXA4	16	10	26	988.31
#123	HDAC2	16	6	22	727.224
#124	PRRX2	16	8	24	490.412
#125	ERG	16	4	20	1098.254
#126	YEATS4	16	17	33	1651.406
#127	SALL2	16	7	23	778.527
#128	ZKSCAN5	16	14	30	1485.949
#129	SMAD5	16	12	28	1671.146
#130	LHX1	16	11	27	1492.859
#131	STAT6	15	12	27	1197.626
#132	BATF3	15	11	26	2312.106
#133	HDAC1	15	11	26	1135.267
#134	RUNX1	15	6	21	562.025
#135	FOXJ3	15	13	28	2002.133
#136	MLLT10	15	14	29	1446.86
#137	GABPB1	15	10	25	1120.21
#138	RCAN1	15	16	31	1104.926
#139	KLF4	15	17	32	2856.712
#140	MAF	15	7	22	1528.269
#141	GATA3	15	13	28	1096.259
#142	TEAD3	15	11	26	1380.568
#143	SOX5	15	10	25	1229.561
#144	MSX2	15	6	21	533.332
#145	FBXW7	15	9	24	838.76
#146	MTA2	15	12	27	2473.341
#147	FOXC1	15	8	23	1064.667
#148	BCL3	15	23	38	2002.625
#149	ZNF3	15	13	28	1791.536
#150	CREBZF	15	16	31	1584.125
#151	TCF3	14	13	27	1043.964
#152	ADNP2	14	11	25	645.249
#153	SNAPC5	14	18	32	1719.07
#154	MEF2C	14	16	30	1696.054
#155	ZFPM2	14	9	23	817.544
#156	ZNF117	14	10	24	1081.435
#157	GTF2IRD1	14	14	28	1077.415
#158	RXRB	14	7	21	626.372
#159	TFDP1	14	10	24	825.764
#160	CREB3L2	14	16	30	1539.123
#161	NOTCH1	14	11	25	1277.918
#162	NR4A1	14	8	22	1290.606
#163	BCL6	14	16	30	1518.976
#164	AHCTF1	14	14	28	1662.697
#165	ECSIT	14	15	29	1351.924
#166	MTA1	14	10	24	1512.183
#167	HSF1	14	11	25	1430.429
#168	CREBL2	14	11	25	679.088
#169	PPARD	14	12	26	1192.042
#170	TULP4	14	9	23	983.938
#171	HOXD11	14	6	20	1489.428
#172	SOX2	14	8	22	1429.356
#173	NOLC1	14	11	25	1211.536
#174	YY1	14	12	26	2179.302
#175	E2F1	14	11	25	1639.647
#176	CNBP	14	10	24	1173.395
#177	BTAF1	14	8	22	425.56
#178	GTF2I	14	7	21	757.622
#179	PBX3	14	15	29	1416.482
#180	PHTF1	13	14	27	1445.778
#181	PA2G4	13	12	25	1567.337
#182	MYNN	13	8	21	683.666
#183	TCF4	13	19	32	1700.76
#184	MLX	13	18	31	1625.492
#185	IRF2	13	13	26	1575.575
#186	TCF7L2	13	14	27	1771.57
#187	HIF1A	13	15	28	2116.291
#188	FOXA1	13	14	27	1723.187
#189	IRF5	13	7	20	2261.102
#190	TSC22D1	13	14	27	1857.826
#191	IRF8	13	14	27	1378.81
#192	ZNF85	13	5	18	560.594
#193	HINFP	13	6	19	669.597
#194	NKX3-1	13	15	28	1480.124
#195	HMGB2	13	15	28	1003.725
#196	FLI1	13	11	24	1143.039
#197	BHLHE40	13	17	30	1856.313
#198	KDM5B	12	14	26	1993.485
#199	TARDBP	12	9	21	1053.787
#200	PHF1	12	15	27	1580.268
#201	PLAGL2	12	10	22	865.485
#202	FOXM1	12	14	26	1816.799
#203	SOX17	12	3	15	558.561
#204	RUNX1T1	12	10	22	625.199
#205	ZNF217	12	18	30	1709.687
#206	CREM	12	15	27	754.098
#207	E2F3	12	22	34	2656.986
#208	NR2F6	12	10	22	736.494
#209	XBP1	12	13	25	1639.848
#210	ZBTB48	12	11	23	879.864
#211	HMG20B	12	14	26	552.363
#212	ZNF91	12	11	23	858.215
#213	IRF1	12	14	26	1135.824
#214	UBN1	12	7	19	700.175
#215	IRX4	12	7	19	1200.249
#216	IRF9	12	7	19	806.957
#217	NFIB	12	15	27	1537.283
#218	DRAP1	12	10	22	661.059
#219	KLF3	12	9	21	1215.295
#220	CREB3L1	12	12	24	1490.104
#221	PFDN1	12	15	27	1644.897
#222	TRIM28	12	13	25	1492.324
#223	ATF4	12	14	26	1738.251
#224	SOX4	12	19	31	2430.496
#225	ZNF281	11	17	28	1104.542
#226	PTTG1	11	11	22	1325.77
#227	ZNF323	11	12	23	1775.683
#228	NFE2L2	11	12	23	1777.369
#229	TSC22D4	11	11	22	741.149
#230	ZNF24	11	8	19	592.294
#231	SP140	11	7	18	1053.85
#232	MBD1	11	9	20	1056.052
#233	SNAPC2	11	10	21	886.023
#234	FOXO3	11	12	23	2390.101
#235	GABPA	11	11	22	834.1
#236	ZNF202	11	10	21	667.054
#237	FOXF2	11	11	22	884.942
#238	WNT5A	11	18	29	1973.902
#239	C2orf3	11	13	24	1259.44
#240	PAX8	11	11	22	624.808
#241	RNF4	11	10	21	891.281
#242	ETV7	11	7	18	342.112
#243	GATA1	11	7	18	627.522
#244	EGR3	11	10	21	537.083
#245	ZNF219	11	13	24	1167.701
#246	ETV1	11	14	25	815.302
#247	LASS6	11	16	27	1136.272
#248	AATF	11	14	25	1346.737
#249	SPEN	11	10	21	816.028
#250	PBX2	11	9	20	1182.864
#251	MYCN	11	10	21	1517.498
#252	SREBF1	10	16	26	1410.542
#253	TEAD4	10	15	25	974.464
#254	HOXA9	10	15	25	1073.687
#255	SOX11	10	5	15	644.433
#256	HOPX	10	6	16	501.066
#257	SIM1	10	6	16	407.691
#258	JUND	10	8	18	757.168
#259	TADA3	10	11	21	1256.641
#260	PEG3	10	9	19	548.303
#261	ZNF134	10	11	21	544.151
#262	UBP1	10	12	22	1274.188
#263	ZFHX4	10	13	23	720.164
#264	BHLHE41	10	17	27	837.27
#265	ATF5	10	10	20	681.64
#266	SLC2A4RG	10	20	30	1358.322
#267	NFYB	10	19	29	1318.157
#268	PKNOX1	10	12	22	1452.256
#269	VTN	10	7	17	852.666
#270	TFAP2A	10	24	34	2331.241
#271	TAF12	10	12	22	1021.541
#272	BARX1	10	8	18	589.965
#273	NFYA	10	17	27	747.352
#274	NR2F2	10	25	35	1492.155
#275	PRDM2	10	7	17	920.237
#276	SMAD4	10	15	25	863.981
#277	SREBF2	10	14	24	1528.191
#278	REST	10	16	26	1663.002
#279	ESR1	10	5	15	557.005
#280	HOXD1	10	7	17	684.501
#281	NR4A2	10	15	25	912.974
#282	CEBPE	10	11	21	443.717
#283	POU4F1	10	14	24	1668.304
#284	ZNF93	10	7	17	469.592
#285	TBX3	10	13	23	531.359
#286	PBX1	10	16	26	1905.059
#287	CREB3	10	11	21	709.523
#288	SATB2	10	18	28	1110.033
#289	ZNF167	10	13	23	1383.346
#290	HOXD13	10	8	18	213.62
#291	PKNOX2	10	11	21	303.125
#292	NFATC1	10	12	22	876.956
#293	MAFB	9	14	23	1363.293
#294	RARB	9	10	19	476.718
#295	FOXF1	9	10	19	562.327
#296	TFCP2	9	16	25	1169.893
#297	CSDA	9	15	24	1437.13
#298	MEF2A	9	8	17	490.624
#299	HOXB7	9	18	27	1956.935
#300	FOXA2	9	12	21	1445.641
#301	TCF7L1	9	14	23	1306.026
#302	TFAM	9	19	28	1130.14
#303	MSRB2	9	19	28	1510.743
#304	STAT3	9	22	31	1312.968
#305	TFDP2	9	17	26	1069.006
#306	IRF3	9	17	26	1044.848
#307	ZGPAT	9	13	22	1060.987
#308	SOX9	9	21	30	2619.442
#309	SCAND1	9	6	15	736.495
#310	KDM5A	9	15	24	1011.39
#311	SIM2	9	11	20	683.052
#312	MAX	9	20	29	1428.606
#313	EGR1	9	14	23	1442.991
#314	MEOX1	9	5	14	526.932
#315	SMAD6	9	14	23	974.114
#316	RELA	9	9	18	463.896
#317	GTF2H4	9	15	24	1161.247
#318	SATB1	9	15	24	667.056
#319	GATAD2A	9	14	23	1112.392
#320	TAF10	9	14	23	686.846
#321	ZIC1	9	24	33	1351.591
#322	ZNF193	9	10	19	933.053
#323	FOXK2	9	16	25	1593.635
#324	EPAS1	9	18	27	956.481
#325	ZNF238	9	22	31	1674.076
#326	HOXA10	9	10	19	726.643
#327	GATA2	9	17	26	1071.923
#328	DLX2	9	18	27	1463.331
#329	TGIF1	8	15	23	579.859
#330	PURA	8	17	25	1076.794
#331	PLSCR1	8	21	29	1181.42
#332	C11orf9	8	17	25	1458.972
#333	HOXB2	8	19	27	2725.906
#334	BRD8	8	16	24	1112.299
#335	ZFP36L2	8	19	27	680.736
#336	KLF1	8	3	11	134.024
#337	GLI2	8	8	16	516.916
#338	ZSCAN18	8	18	26	1762.125
#339	HHEX	8	11	19	542.69
#340	HMGA1	8	21	29	1483.967
#341	PITX1	8	15	23	882.994
#342	SOLH	8	16	24	1241.147
#343	RERE	8	16	24	954.89
#344	ATF3	8	14	22	1030.876
#345	BTG2	8	12	20	654.847
#346	MSC	8	18	26	3543.23
#347	AFF1	8	19	27	1226.617
#348	ARNTL	8	12	20	775.166
#349	DLX4	8	7	15	613.813
#350	ZNF274	8	20	28	1125.475
#351	MSX1	8	16	24	1499.836
#352	AEBP1	8	9	17	548.534
#353	ZNF175	8	11	19	1797.468
#354	TCFL5	8	12	20	682.665
#355	FOXD1	8	22	30	2144.791
#356	HOXB9	8	11	19	697.764
#357	TRPS1	8	12	20	1414.356
#358	HOXD10	8	9	17	648.203
#359	NFYC	8	16	24	1114.488
#360	CTNNB1	8	16	24	1679.073
#361	E2F6	8	12	20	689.033
#362	RARA	8	13	21	834.41
#363	ISL1	8	5	13	424.237
#364	MECOM	8	18	26	1266.92
#365	EGR2	8	6	14	476.078
#366	JUNB	8	18	26	853.382
#367	DMRT1	8	7	15	447.794
#368	CUX1	7	14	21	622.967
#369	ZHX3	7	12	19	542.383
#370	BACH2	7	15	22	967.211
#371	NFE2L1	7	13	20	610.189
#372	NFE2L3	7	15	22	813.919
#373	HOXA1	7	10	17	514.013
#374	POU4F2	7	5	12	942.222
#375	MEIS1	7	13	20	1716.614
#376	LMO4	7	16	23	1733.856
#377	PGR	7	3	10	195.957
#378	HIRA	7	20	27	1496.119
#379	FOXO1	7	12	19	1126.529
#380	ZNF148	7	15	22	1072.158
#381	MZF1	7	11	18	486.113
#382	ZNF83	7	17	24	1434.462
#383	HNRNPAB	7	12	19	722.326
#384	RFX5	7	22	29	2375.42
#385	LHX2	7	10	17	537.037
#386	PITX2	7	8	15	377.575
#387	MNT	7	11	18	662.861
#388	LZTR1	7	17	24	1001.385
#389	ETS1	7	19	26	1123.823
#390	HR	7	15	22	876.05
#391	ZNF268	7	12	19	743.889
#392	BUD31	7	6	13	619.908
#393	ARID3A	7	14	21	655.469
#394	KLF6	7	18	25	513.727
#395	HOXC10	7	18	25	1091.714
#396	ELF4	7	23	30	1248.077
#397	TRIM22	7	23	30	1414.576
#398	HOXA11	7	9	16	1085.856
#399	RUNX3	7	13	20	839.426
#400	HOXB13	6	8	14	412.759
#401	FOXL2	6	14	20	627.957
#402	NR1D2	6	18	24	864.993
#403	TCF12	6	17	23	730.165
#404	FOS	6	15	21	457.899
#405	CTBP1	6	14	20	374.598
#406	KLF11	6	17	23	872.057
#407	STRN3	6	13	19	951.966
#408	T	6	5	11	351.883
#409	CEBPD	6	16	22	774.663
#410	MEIS2	6	19	25	899.518
#411	GATA6	6	20	26	1108.729
#412	ENO1	6	12	18	502.027
#413	TCF25	6	13	19	650.802
#414	ZNF140	6	13	19	1051.775
#415	NR2E1	6	7	13	607.027
#416	SOX12	6	16	22	789.967
#417	CLOCK	6	10	16	681.998
#418	ZSCAN16	6	11	17	408.502
#419	EDF1	6	13	19	1112.457
#420	NR1H2	6	11	17	434.159
#421	TFAP2C	6	19	25	1383.525
#422	NFKB1	6	11	17	830.033
#423	SUPT6H	6	13	19	732.2
#424	HOXC4	6	11	17	338.744
#425	TAF1B	6	15	21	1590.181
#426	SCMH1	6	14	20	998.456
#427	NFX1	6	9	15	437.756
#428	AHR	6	24	30	1975.43
#429	ELK4	5	7	12	446.208
#430	CDKN2A	5	23	28	1030.59
#431	TP63	5	11	16	531.527
#432	GATAD1	5	13	18	733.976
#433	EN2	5	17	22	303.161
#434	MEOX2	5	7	12	192.43
#435	NCOR1	5	13	18	474.839
#436	SIX1	5	9	14	343.625
#437	TAF7	5	15	20	959.715
#438	SCML2	5	10	15	313.076
#439	SIX2	5	6	11	363.907
#440	SIX6	5	2	7	47.925
#441	HMBOX1	5	10	15	285.951
#442	YBX1	5	17	22	915.66
#443	ETS2	5	18	23	772.619
#444	ATF6	5	19	24	2169.572
#445	HMGA2	5	18	23	1053.6
#446	ZNF207	5	16	21	1172.023
#447	NR2F1	4	20	24	786.847
#448	BACH1	4	12	16	319.148
#449	ZHX2	4	15	19	298.287
#450	LASS2	4	12	16	572.605
#451	WT1	4	17	21	654.578
#452	VDR	4	16	20	516.173
#453	NFKB2	4	6	10	271.212
#454	IRF7	4	8	12	286.394
#455	SRF	4	18	22	630.563
#456	DMTF1	4	13	17	931.153
#457	CEBPB	4	10	14	675.085
#458	CITED2	4	17	21	306.825
#459	NKX2-5	4	7	11	458.25
#460	CREBBP	4	16	20	514.556
#461	ERF	4	11	15	380.027
#462	TCEAL1	4	14	18	463.826
#463	MSL3	4	15	19	558.001
#464	CNOT7	4	16	20	1005.852
#465	SALL1	4	7	11	223.389
#466	TAF6	4	12	16	586.113
#467	HOXB6	4	18	22	482.636
#468	MYBL2	3	14	17	458.985
#469	SMAD1	3	14	17	339.365
#470	RORA	3	10	13	362.282
#471	SLC30A9	3	14	17	204.589
#472	TP53	3	24	27	851.086
#473	RFXANK	3	15	18	597.658
#474	HOXD4	3	13	16	190.555
#475	SUPT4H1	3	17	20	1652.053
#476	E2F5	3	15	18	372.596
#477	ZNF174	3	15	18	385.777
#478	ZNF277	3	17	20	431.634
#479	NR2C1	3	17	20	822.384
#480	POU3F2	3	14	17	161.988
#481	PLAG1	3	15	18	642.308
#482	CBFB	3	16	19	446.664
#483	IRX5	3	14	17	375.419
#484	SMAD2	3	12	15	454.037
#485	HES1	3	17	20	355.432
#486	RXRA	3	22	25	575.915
#487	NKX2-1	2	10	12	503.184
#488	STAT4	2	10	12	109.679
#489	RBPJ	2	15	17	272.781
#490	ZNF232	2	16	18	186.033
#491	DDIT3	2	15	17	240.451
#492	PAX6	2	17	19	462.419
#493	ZNF131	2	13	15	162.642
#494	TSC22D3	2	14	16	221.842
#495	NR0B1	2	18	20	711.486
#496	CREB5	2	16	18	415.555
#497	ZNF189	2	13	15	138.88
#498	PROX1	1	10	11	113.692
#499	KLF2	1	15	16	108.53
#500	TFAP2B	0	10	10	0