Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	HOXB3	120	1	121	35.88
#2	THRA	102	7	109	2791.254
#3	RUNX2	91	6	97	186.025
#4	HCFC1	82	7	89	1446.653
#5	VSX1	72	2	74	979.44
#6	TBX10	72	8	80	2944.488
#7	LEF1	68	4	72	1410.254
#8	REST	66	6	72	6159.322
#9	ELK1	66	5	71	1006.543
#10	NFAT5	59	9	68	13125.226
#11	SCAND2	57	3	60	131.754
#12	PAX3	52	6	58	3155.752
#13	GTF2I	49	7	56	12606.142
#14	MEF2C	48	8	56	1421.976
#15	POU6F1	46	7	53	289.977
#16	TBX1	46	6	52	332.173
#17	RARB	44	3	47	124.895
#18	ATF5	43	4	47	66.868
#19	E2F5	41	12	53	1900.891
#20	PAX8	40	8	48	47571.249
#21	GATA1	40	6	46	1317.969
#22	FOXE1	39	6	45	1305.201
#23	RARA	38	9	47	203.382
#24	TCF7	37	9	46	1968.559
#25	HR	37	14	51	808.897
#26	FOXG1	36	5	41	6889.401
#27	NR2E3	36	6	42	402.087
#28	NKX2-1	36	9	45	2183.465
#29	NKX2-5	35	10	45	302.428
#30	RERE	35	17	52	2015.954
#31	TRIM29	35	6	41	589.194
#32	SMAD6	34	14	48	10484.498
#33	TRIM22	34	14	48	2246.135
#34	TP63	34	3	37	389.38
#35	HOXD11	34	9	43	1587.377
#36	TLX2	34	12	46	2905.245
#37	FOXM1	34	6	40	713.671
#38	IRF6	34	8	42	1102.551
#39	CBL	32	11	43	581.239
#40	CLOCK	32	5	37	2469.227
#41	KLF5	32	13	45	2362.054
#42	SNAI2	32	9	41	1958.543
#43	CREBL2	32	18	50	3904.172
#44	NFATC1	32	8	40	92.931
#45	BUD31	31	7	38	2265.93
#46	ZNF154	30	3	33	6625.578
#47	GCM1	30	9	39	1048.623
#48	HNF4A	30	12	42	3698.411
#49	NFE2L2	29	5	34	2245.21
#50	SMAD5	29	10	39	324.575
#51	HOXB9	28	9	37	1010.356
#52	PBX2	28	8	36	66.693
#53	IRF8	28	6	34	795.018
#54	TFEC	28	12	40	2351.463
#55	NFYB	28	11	39	778.489
#56	EN1	27	17	44	7934.405
#57	MSX1	27	15	42	1115.403
#58	GLI2	27	7	34	1664.675
#59	E2F1	27	6	33	74.636
#60	IRX4	27	16	43	5675.99
#61	HOPX	26	15	41	3054.38
#62	TCF4	26	13	39	2780.175
#63	TCF21	26	4	30	961.845
#64	BCL11B	26	11	37	309.447
#65	LMO4	26	13	39	472.188
#66	LASS6	26	18	44	588.179
#67	SPEN	26	12	38	745.386
#68	GAS7	25	7	32	327.544
#69	MLLT10	25	11	36	4103.368
#70	CREBBP	25	13	38	288.396
#71	FLI1	25	4	29	1250.922
#72	ZKSCAN5	25	14	39	756.982
#73	GTF2H3	25	10	35	568.873
#74	PKNOX1	25	11	36	839.469
#75	RBPJ	24	14	38	539.489
#76	AFF1	24	12	36	1657.928
#77	HIF3A	24	9	33	166.102
#78	SOX2	24	12	36	1452.969
#79	MGA	24	13	37	322.237
#80	ZNF75D	24	13	37	655.531
#81	BNC1	24	11	35	1661.855
#82	RUNX1T1	24	10	34	4339.572
#83	ADNP	24	14	38	2562.457
#84	CREB1	23	12	35	499.797
#85	USF2	23	12	35	831.471
#86	NR3C2	23	16	39	2011.606
#87	PITX1	23	15	38	742.021
#88	HMX1	23	10	33	1570.221
#89	CITED2	23	13	36	627.056
#90	SOX12	23	16	39	667.561
#91	TRIM28	23	15	38	1218.887
#92	ZNF500	23	7	30	51.291
#93	HOXC5	23	10	33	85.126
#94	CNOT8	22	12	34	1084.307
#95	ZNF236	22	10	32	1547.947
#96	TAL1	22	10	32	358.834
#97	NKX6-1	22	7	29	694.582
#98	ZEB1	22	15	37	1038.171
#99	VAX2	22	11	33	444.19
#100	FUBP1	22	20	42	2565.962
#101	MLL	22	9	31	766.352
#102	ZNF85	22	16	38	1327.394
#103	ESR1	22	16	38	4509.595
#104	KLF2	22	6	28	1870.924
#105	NR2F2	22	10	32	289.62
#106	ZNF131	22	14	36	5540.084
#107	TAF6	21	11	32	895.706
#108	GBX2	21	9	30	352.179
#109	HOXA3	21	14	35	978.662
#110	SMAD4	21	18	39	3751.411
#111	JUNB	21	10	31	3067.578
#112	TCF3	21	9	30	81.86
#113	CSRNP2	21	12	33	442.188
#114	AHCTF1	21	13	34	598.212
#115	TBX5	20	9	29	246.433
#116	CSDA	20	13	33	1313.856
#117	CNBP	20	16	36	1834.816
#118	PHF1	20	13	33	1561.318
#119	CDX2	20	11	31	762.827
#120	CREM	20	13	33	396.884
#121	GTF2H4	19	16	35	754.845
#122	NOTCH1	19	12	31	814.818
#123	YBX1	19	13	32	2328.507
#124	ZGPAT	19	10	29	1903.486
#125	ZNF444	19	12	31	518.559
#126	IKZF4	19	9	28	1165.733
#127	TBX6	19	12	31	229.523
#128	KLF9	19	16	35	980.487
#129	IRF1	19	9	28	1656.554
#130	ARNTL2	19	13	32	770.161
#131	HSF2	19	13	32	2502.3
#132	GATAD2A	18	13	31	213.559
#133	PRDM2	18	11	29	998.64
#134	CREBZF	18	10	28	369.969
#135	TEAD4	18	11	29	1163.846
#136	FOXD1	18	17	35	3030.058
#137	SOX15	18	11	29	885.29
#138	TBX3	18	15	33	1564.557
#139	MYBL2	18	12	30	455.179
#140	ZKSCAN4	17	11	28	216.941
#141	TFAM	17	14	31	499.082
#142	HMGA1	17	17	34	1653.609
#143	HNF1B	17	15	32	1861.77
#144	MYNN	17	15	32	7326.666
#145	FOXL2	17	18	35	5594.057
#146	YY1	17	15	32	1178.922
#147	PHTF1	17	16	33	543.89
#148	FOSL2	17	14	31	1815.923
#149	NFYC	17	11	28	817.869
#150	ARID3A	17	7	24	406.22
#151	PLSCR1	17	13	30	327.016
#152	HOXD13	17	10	27	847.711
#153	TSHZ2	17	10	27	92.588
#154	E2F3	17	18	35	851.446
#155	VAV1	17	11	28	596.717
#156	PRRX1	16	16	32	501.535
#157	GRHL2	16	11	27	2442.572
#158	SPI1	16	9	25	692.415
#159	MZF1	16	13	29	466.081
#160	MYOG	16	14	30	405.189
#161	FOSB	16	2	18	255.038
#162	SREBF2	16	15	31	1134.047
#163	XBP1	16	18	34	864.304
#164	PLAGL2	16	16	32	1877.884
#165	RXRB	16	9	25	94.422
#166	MLXIPL	16	12	28	451.462
#167	GABPB1	16	13	29	835.997
#168	HMGB2	16	12	28	578.709
#169	ZNF187	15	12	27	649.646
#170	HOXA10	15	21	36	2843.475
#171	ETV7	15	13	28	618.507
#172	EPAS1	15	16	31	1432.159
#173	NFIL3	15	9	24	2081.087
#174	TBX2	15	7	22	1849.246
#175	ELF1	15	11	26	1641.657
#176	MITF	15	13	28	1126.772
#177	TFEB	14	14	28	1215.206
#178	ATF3	14	6	20	1143.846
#179	STAT1	14	16	30	1350.978
#180	ZEB2	14	10	24	331.875
#181	CREB3L1	14	16	30	4072.101
#182	TCF25	14	9	23	197.925
#183	ETV6	14	9	23	235.322
#184	PAX6	14	15	29	6288.978
#185	IKZF1	14	12	26	650.439
#186	MLX	13	8	21	800.527
#187	OVOL1	13	13	26	876.714
#188	FOSL1	13	17	30	1998.273
#189	RFX5	13	12	25	685.081
#190	SPIB	13	11	24	2054.868
#191	ZBTB17	13	11	24	412.613
#192	SALL2	13	19	32	2366.343
#193	ECSIT	13	14	27	812.054
#194	NFATC4	13	15	28	239.803
#195	ERF	13	11	24	1328.923
#196	ATF2	13	12	25	332.592
#197	TSC22D3	13	16	29	1717.127
#198	ELK3	13	16	29	1462.458
#199	NFKB2	13	13	26	764.648
#200	MAFB	13	14	27	911.547
#201	PTTG1	13	13	26	1088.227
#202	ZSCAN16	13	13	26	1015.387
#203	EVX1	13	13	26	223.839
#204	C2orf3	12	15	27	2038.124
#205	TFDP1	12	14	26	1800.203
#206	TWIST1	12	20	32	3024.167
#207	ESRRA	12	9	21	122.334
#208	NR2C1	12	16	28	1149.988
#209	TAF4	12	17	29	3497.181
#210	NFIX	12	8	20	118.766
#211	ZNF167	12	12	24	824.613
#212	LHX3	12	14	26	325.568
#213	NR4A1	12	2	14	188.385
#214	FOXA2	12	16	28	2310.047
#215	YEATS4	12	18	30	3562.75
#216	SP140	12	6	18	821.751
#217	NR5A1	12	7	19	196.623
#218	FOXO4	12	10	22	109.502
#219	TBX19	12	7	19	251.221
#220	ZNF193	12	14	26	484.175
#221	CREB3L2	12	21	33	2351.912
#222	ZNF148	12	15	27	3406.292
#223	UBN1	11	16	27	94.445
#224	DLX4	11	19	30	1218.33
#225	BTG2	11	20	31	1232.901
#226	SP3	11	14	25	785.71
#227	CUX1	11	15	26	2420.953
#228	HDAC2	11	18	29	14490.926
#229	NR2F1	11	12	23	1738.537
#230	ZFP36L1	11	14	25	130.609
#231	HOXC13	11	17	28	8699.096
#232	KLF10	11	11	22	876.007
#233	FOXJ3	11	14	25	651.278
#234	TCF15	11	9	20	59.651
#235	TFDP2	10	17	27	829.266
#236	ADNP2	10	13	23	158.325
#237	GCFC1	10	18	28	2760.779
#238	KLF11	10	21	31	2004.99
#239	PBX3	10	19	29	888.166
#240	TFCP2	10	14	24	697.001
#241	NR3C1	10	17	27	346.718
#242	ENO1	10	18	28	756.947
#243	ZNF207	10	12	22	333.736
#244	WNT5A	10	18	28	1560.403
#245	RCOR1	10	12	22	777.923
#246	ZNF140	10	15	25	1017.274
#247	ZNF238	10	17	27	1544.321
#248	IRF4	10	16	26	843.936
#249	ATF1	10	14	24	2835.169
#250	NR1I2	10	9	19	15836.763
#251	NFE2	10	16	26	850.86
#252	RXRA	10	17	27	493.822
#253	E2F6	10	14	24	1104.592
#254	FOXN3	10	13	23	1210.969
#255	SOX9	10	25	35	1043.73
#256	GATA3	10	18	28	2711.074
#257	TCF12	10	14	24	1525.741
#258	ERG	10	11	21	1036.597
#259	EDF1	10	6	16	233.94
#260	GTF2IRD1	10	18	28	1159.512
#261	HMG20A	10	11	21	2892.857
#262	MMP14	10	15	25	1805.128
#263	PRRX2	10	13	23	304.958
#264	KLF6	10	14	24	1162.116
#265	ELF4	10	20	30	2576.002
#266	PEG3	10	17	27	829.199
#267	NR4A2	9	9	18	767.873
#268	TAF7	9	16	25	1951.994
#269	MTA1	9	14	23	813.623
#270	ZNF83	9	20	29	1997.623
#271	MEOX2	9	11	20	1574.779
#272	FOS	9	11	20	695.778
#273	IRF7	9	19	28	824.825
#274	IRF2	9	16	25	1638.249
#275	C11orf9	9	13	22	4585.709
#276	FOXO3	9	24	33	728.837
#277	TFAP2A	9	16	25	277.419
#278	MEF2A	9	13	22	268.323
#279	NFIC	9	10	19	93.898
#280	CEBPB	9	22	31	2193.302
#281	KDM5B	9	17	26	585.77
#282	FOXF1	9	12	21	409.714
#283	CCRN4L	9	10	19	96.861
#284	ARNT	9	14	23	680.88
#285	HOXA5	9	9	18	1725.27
#286	ZFHX3	9	17	26	1318.554
#287	GATAD1	9	16	25	956.088
#288	MYCL1	9	25	34	2634.314
#289	DDIT3	9	21	30	1843.314
#290	FOXP3	9	5	14	17.832
#291	CTNNB1	8	11	19	83.235
#292	STRN3	8	21	29	484.581
#293	STAT3	8	23	31	660.122
#294	SOX13	8	18	26	1631.569
#295	MEIS3P1	8	27	35	2238.296
#296	REL	8	18	26	508.015
#297	ETV4	8	13	21	850.236
#298	NR2F6	8	20	28	1102.824
#299	WT1	8	14	22	48348.042
#300	SOX4	8	16	24	1070.252
#301	FOXO1	8	16	24	1310.139
#302	SOX21	8	10	18	21.93
#303	MAF	8	14	22	636.798
#304	ZFP36L2	8	22	30	1713.506
#305	SCML1	8	16	24	2691.678
#306	SOLH	8	14	22	350.243
#307	HOXC4	8	14	22	14277.686
#308	TARDBP	8	14	22	719.802
#309	BACH2	8	17	25	6177.719
#310	IRX5	8	16	24	187.74
#311	MYC	8	20	28	2066.422
#312	ZNF394	8	16	24	335.118
#313	MYT1	8	8	16	329.379
#314	DLX2	8	15	23	491.824
#315	ZKSCAN1	8	15	23	1936.91
#316	PA2G4	7	17	24	1106.413
#317	BHLHE41	7	21	28	1340.103
#318	RELA	7	14	21	719.917
#319	NOLC1	7	15	22	981.87
#320	E2F8	7	16	23	651.065
#321	POU2F2	7	11	18	221.605
#322	AEBP1	7	16	23	674.935
#323	DMTF1	7	15	22	790.69
#324	MEIS1	7	17	24	667.677
#325	ZNF232	7	18	25	434.377
#326	TULP4	7	18	25	493.785
#327	ARNTL	7	9	16	129.092
#328	ZNF45	7	17	24	431.142
#329	ZFPM2	7	10	17	446.825
#330	BACH1	7	13	20	324.268
#331	RCAN1	7	16	23	437.988
#332	JUN	7	14	21	901.955
#333	RUNX1	7	14	21	1284.303
#334	HOXA9	7	10	17	161.2
#335	HMGA2	7	16	23	289.513
#336	STAT5B	7	12	19	205.811
#337	JUND	7	19	26	912.111
#338	KLF4	7	24	31	3175.133
#339	DRAP1	7	22	29	1297.356
#340	HNRNPAB	7	21	28	274.253
#341	ZNF281	7	18	25	241.693
#342	ZNF24	7	17	24	1754.418
#343	SOX17	7	10	17	739.368
#344	MSC	7	20	27	2207.009
#345	HOXD1	7	17	24	463.338
#346	HNRNPK	7	11	18	472.716
#347	LZTR1	6	9	15	36.689
#348	MECOM	6	22	28	2677.63
#349	ETV1	6	22	28	3718.15
#350	MSX2	6	11	17	1660.037
#351	NR1H4	6	12	18	7655.761
#352	RB1	6	11	17	297.429
#353	FOXJ1	6	20	26	1417.082
#354	LZTS1	6	9	15	170.719
#355	HOXB5	6	11	17	2307.727
#356	LASS2	6	15	21	943.211
#357	ZNF217	6	16	22	1237.958
#358	BLZF1	6	11	17	621.542
#359	EGR3	6	17	23	1114.606
#360	HHEX	6	20	26	1924.513
#361	MAFF	6	16	22	1000.038
#362	PPARG	6	25	31	1813.835
#363	CEBPD	6	24	30	806.762
#364	TCF7L1	6	18	24	2158.132
#365	ZNF175	6	11	17	54.242
#366	SIX2	6	22	28	5173.965
#367	HOXB6	6	16	22	4510.749
#368	TRPS1	6	17	23	496.783
#369	VTN	6	13	19	1399.849
#370	SCAND1	5	14	19	1225.82
#371	FOXF2	5	18	23	2903.981
#372	TEAD3	5	12	17	324.675
#373	ZNF3	5	17	22	2658.113
#374	HOXD9	5	11	16	50.869
#375	EGR1	5	12	17	271.005
#376	HOXA1	5	13	18	574.177
#377	PURA	5	19	24	1395.489
#378	TGIF2	5	19	24	425.886
#379	NFE2L1	5	16	21	537.607
#380	TCFL5	5	14	19	479.549
#381	SIX3	5	18	23	10261.581
#382	PPARD	5	10	15	60.124
#383	NFX1	5	6	11	23.364
#384	ATF6	5	17	22	282.549
#385	MYCN	5	18	23	1664.213
#386	ETS2	5	22	27	2966.538
#387	TCF7L2	5	14	19	1331.37
#388	ZNF93	5	11	16	77.851
#389	KDM5A	5	14	19	572.839
#390	VDR	5	18	23	2875.68
#391	HES1	5	20	25	332.686
#392	HCLS1	5	22	27	2729.199
#393	HIF1A	5	16	21	814.54
#394	NFATC3	5	18	23	2873.186
#395	GATA2	5	16	21	256.733
#396	NKX2-8	5	13	18	72.394
#397	MAX	5	21	26	1223.202
#398	ASCL1	5	18	23	5637.726
#399	NFIB	5	25	30	574.017
#400	HOXC10	5	22	27	20792.309
#401	RBCK1	5	20	25	1086.824
#402	MAFG	5	15	20	1506.135
#403	GATA6	5	20	25	1203.395
#404	TSC22D1	5	21	26	468.745
#405	SOX11	5	8	13	705.174
#406	NR0B1	5	22	27	2495.25
#407	ZNF165	5	18	23	581.765
#408	HDAC1	5	20	25	836.805
#409	TAF5	5	20	25	233.902
#410	FOXI1	5	21	26	2735.303
#411	HEY1	4	22	26	398.031
#412	TCEAL1	4	12	16	114.076
#413	NCOR1	4	18	22	697.423
#414	ZBTB38	4	16	20	268.33
#415	ZNF274	4	19	23	341.346
#416	CREB5	4	11	15	59.326
#417	PLAG1	4	17	21	961.071
#418	HOXD4	4	17	21	4233.406
#419	NR1H2	4	16	20	129.484
#420	ZNF133	4	19	23	235.868
#421	IRF9	4	13	17	540.165
#422	ELF3	4	16	20	572.137
#423	EHF	4	17	21	551.566
#424	RFXANK	4	19	23	1048.515
#425	LHX2	4	20	24	3368.826
#426	SMAD2	4	18	22	434.821
#427	GLI3	4	13	17	59.993
#428	ELF5	4	24	28	1944.707
#429	BRD8	4	17	21	328.893
#430	PCGF2	4	28	32	543.719
#431	SPDEF	4	16	20	417.578
#432	ZNF277	4	17	21	153.613
#433	TSC22D2	4	20	24	888.373
#434	SIX1	4	21	25	2220.764
#435	SLC2A4RG	4	12	16	242.588
#436	AHR	3	21	24	1468.285
#437	MEIS2	3	22	25	531.002
#438	TCF20	3	19	22	177.264
#439	ZNF91	3	19	22	167.026
#440	ZHX2	3	20	23	2550.657
#441	TFAP2C	3	24	27	7759.941
#442	MSRB2	3	18	21	1526.097
#443	BHLHE40	3	14	17	328.503
#444	ZIC1	3	23	26	3700.665
#445	BATF	3	11	14	1141.66
#446	SMAD3	3	18	21	447.844
#447	STAT4	3	17	20	883.629
#448	BARX1	3	12	15	349.376
#449	HOXB7	3	18	21	924.353
#450	HMGB1	3	24	27	621.155
#451	ETV5	3	18	21	2782.939
#452	SUPT4H1	3	14	17	97.676
#453	SMAD1	3	18	21	1267.837
#454	BCL3	3	19	22	859.593
#455	EGR2	3	16	19	867.238
#456	MNX1	3	13	16	277.581
#457	CBFB	3	13	16	202.057
#458	CDKN2A	2	22	24	400.472
#459	TFCP2L1	2	21	23	639.049
#460	STAT6	2	18	20	160.517
#461	TP53	2	17	19	88.276
#462	NPAS2	2	23	25	255.33
#463	TGIF1	2	17	19	1493.03
#464	SLC30A9	2	17	19	1142.557
#465	RUNX3	2	19	21	139.502
#466	NFYA	2	12	14	178.518
#467	PBX1	2	26	28	923.084
#468	HOXB2	2	22	24	175.068
#469	BTAF1	2	15	17	94.091
#470	ISL1	2	21	23	1444.271
#471	FBXW7	2	17	19	108.224
#472	NR1D2	2	18	20	3817.561
#473	PRDM1	2	15	17	87.132
#474	HLF	2	22	24	349.495
#475	RORA	2	20	22	579.06
#476	FOXK2	2	14	16	150.712
#477	HMBOX1	2	23	25	202.654
#478	HSF1	2	21	23	191.339
#479	SUPT6H	2	11	13	18.914
#480	SATB1	2	20	22	674.036
#481	NR4A3	2	16	18	112.483
#482	CEBPA	1	26	27	67.681
#483	HIRA	1	18	19	78.333
#484	CTBP1	1	17	18	115.543
#485	KLF7	1	19	20	58.911
#486	ZNF323	1	24	25	601.092
#487	ZNF268	1	16	17	263.83
#488	ZSCAN18	1	17	18	253.305
#489	ARNT2	1	20	21	825.583
#490	BCL6	1	17	18	271.792
#491	ZNF117	1	25	26	51.064
#492	NR1H3	1	16	17	464.392
#493	HMG20B	1	16	17	133.196
#494	SREBF1	1	18	19	52.361
#495	FOXA1	1	19	20	87.886
#496	NFE2L3	1	15	16	43.384
#497	FOXC1	1	13	14	74.217
#498	PITX2	0	19	19	0
#499	NKX3-1	0	19	19	0
#500	SATB2	0	17	17	0