Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	SNAI2	57	2	59	33.194
#2	IRF6	53	1	54	264.265
#3	ZNF639	52	12	64	901.27
#4	TRIM29	49	2	51	1636.077
#5	NKX2-1	49	5	54	98.478
#6	TP63	44	2	46	263.438
#7	SOX2	44	5	49	86.841
#8	MAX	43	1	44	54.489
#9	IKZF1	42	6	48	1324.283
#10	ENO1	39	4	43	2012.332
#11	FOXM1	38	6	44	210.598
#12	FOXD1	38	10	48	609.555
#13	KLF5	38	7	45	238.905
#14	MEF2C	37	8	45	930.984
#15	KLF2	37	6	43	274.988
#16	CITED2	35	8	43	1598.799
#17	RARA	35	6	41	1467.313
#18	ZNF367	34	4	38	8053.601
#19	PITX1	34	9	43	799.493
#20	REL	33	5	38	997.516
#21	E2F7	33	6	39	3730.784
#22	UHRF1	33	5	38	627.771
#23	ETS1	33	5	38	568.534
#24	MYC	32	7	39	905.997
#25	DMRT2	31	11	42	473.899
#26	CSDA	31	10	41	563.86
#27	TBX3	31	11	42	4022.065
#28	NFYA	31	8	39	346.285
#29	GABPB1	30	13	43	2109.949
#30	MYBL2	30	9	39	404.159
#31	HIC1	30	7	37	787.893
#32	RXRB	30	5	35	328.793
#33	HOXB7	29	7	36	384.059
#34	CREB3L1	28	9	37	842.024
#35	FOSL1	28	9	37	677.724
#36	STAT6	28	9	37	1288.333
#37	ZNF3	27	10	37	1636.679
#38	ZFHX3	27	11	38	1522.293
#39	HR	27	10	37	336.639
#40	DLX6	27	14	41	1314.666
#41	GRHL3	26	8	34	456.986
#42	TAF12	26	14	40	1547.701
#43	BCL3	26	9	35	2090.663
#44	GLI2	26	12	38	4112.824
#45	NFIX	26	13	39	1527.419
#46	C2orf3	25	15	40	719.657
#47	HOXA10	25	12	37	851.507
#48	MSC	25	8	33	719.481
#49	TFAP2A	25	12	37	295.289
#50	SOX4	25	10	35	1786.071
#51	ELF3	25	19	44	2647.391
#52	HEY1	25	9	34	436.092
#53	SUPT6H	24	8	32	1524.611
#54	ARID4A	24	11	35	1185.96
#55	GLIS3	23	16	39	1967.041
#56	RORC	23	10	33	1343.749
#57	BHLHE40	23	9	32	651.54
#58	ZFP36L2	23	13	36	2262.395
#59	SPI1	23	14	37	1445.216
#60	PBX1	23	16	39	1151.232
#61	ETV1	22	14	36	1453.959
#62	TCF21	22	7	29	177.07
#63	BNC1	22	7	29	45
#64	TULP4	22	12	34	919.112
#65	EGR2	22	12	34	2818.078
#66	ZIC2	22	15	37	1232.708
#67	ELF1	22	9	31	796.941
#68	TEAD2	22	10	32	1103.458
#69	FOXE1	22	9	31	1674.483
#70	E2F1	22	8	30	765.435
#71	SIX5	22	12	34	1895.007
#72	HOXB6	21	9	30	1131.319
#73	BTG2	21	11	32	1099.236
#74	SOX15	21	5	26	41.298
#75	EN1	21	11	32	1219.34
#76	NFIB	21	13	34	1799.861
#77	TCF3	21	11	32	3294.693
#78	TFDP2	21	12	33	772.874
#79	GATA6	21	11	32	797.502
#80	SPEN	21	14	35	924.931
#81	HOXB8	21	5	26	685.966
#82	TEAD4	21	8	29	294.946
#83	ZFHX4	21	12	33	1815.192
#84	MMP14	21	19	40	1774.318
#85	FOXJ1	21	10	31	429.586
#86	MAFK	21	11	32	978.275
#87	FOXA2	20	17	37	752.645
#88	ZEB2	20	9	29	558.806
#89	TP53	20	16	36	868.583
#90	FOXP2	20	11	31	561.335
#91	ZNF277	20	9	29	1463.407
#92	VAV1	20	12	32	869.69
#93	CSRNP3	20	12	32	972.767
#94	ESR1	20	17	37	2723.133
#95	KLF6	20	10	30	1830.492
#96	KLF16	19	10	29	293.442
#97	NR0B1	19	18	37	1916.073
#98	KDM5B	19	13	32	2441.051
#99	KLF9	19	15	34	1360.594
#100	HOXA13	19	13	32	1144.037
#101	NKX2-5	19	14	33	1425.57
#102	THRB	19	17	36	1742.821
#103	EGR1	19	7	26	884.168
#104	WNT5A	19	12	31	363.803
#105	CEBPA	19	22	41	2045.377
#106	LHX2	19	15	34	1151.391
#107	HOXA1	19	11	30	1056.993
#108	HOXB1	19	16	35	1355.808
#109	IRX4	19	18	37	1139.972
#110	TFAP2C	18	16	34	782.519
#111	SMAD3	18	9	27	536.323
#112	SOX13	18	13	31	981.52
#113	FOXA3	18	9	27	872.596
#114	HOXD9	18	12	30	1087.508
#115	IRX1	18	10	28	643.039
#116	SATB2	18	16	34	2153.475
#117	GABPA	18	12	30	291.221
#118	ZNF236	18	18	36	2472.472
#119	ASCL2	18	15	33	628.224
#120	KLF4	18	14	32	486.967
#121	SOX9	18	18	36	1840.916
#122	TRPS1	18	16	34	1784.557
#123	ZNF238	18	13	31	1548.624
#124	TSC22D3	18	19	37	1971.106
#125	ARNTL	18	16	34	1505.876
#126	ARNTL2	18	18	36	1437.181
#127	NFATC2	18	10	28	1025.48
#128	SALL1	17	16	33	775.84
#129	PKNOX2	17	6	23	108.558
#130	HOPX	17	10	27	627.078
#131	ALX3	17	15	32	1398.693
#132	MBD1	17	12	29	666.941
#133	TFAP4	17	13	30	1240.034
#134	STAT1	17	15	32	902.758
#135	EPAS1	17	12	29	668.207
#136	SOX7	17	13	30	846.967
#137	TWIST1	17	16	33	854.239
#138	SPDEF	17	15	32	723.114
#139	ETV5	17	11	28	859.67
#140	DMRT1	17	15	32	1047.304
#141	MEOX2	16	16	32	1542.311
#142	POU3F4	16	10	26	1454.167
#143	ERG	16	10	26	1001.171
#144	VTN	16	12	28	419.76
#145	ARNT	16	21	37	1944.704
#146	CTBP1	16	8	24	867.839
#147	ZNF169	16	13	29	2234.516
#148	JUND	16	15	31	1801.008
#149	MYF6	16	12	28	1057.488
#150	FOSB	16	5	21	242.296
#151	PAX6	16	14	30	1199.63
#152	LASS6	16	18	34	846.687
#153	AFF4	16	16	32	1529.027
#154	NOTCH1	16	12	28	996.247
#155	TBX1	16	15	31	1082.034
#156	LEF1	16	16	32	2783.941
#157	NR2C1	16	16	32	2465.32
#158	NR5A2	16	17	33	1546.013
#159	C12orf28	16	11	27	1797.625
#160	FOS	16	9	25	881.071
#161	HOXD10	16	9	25	315.054
#162	EBF1	16	19	35	2186.41
#163	NFE2L2	15	7	22	298.73
#164	ZNF496	15	11	26	1148.733
#165	PITX2	15	19	34	1619.492
#166	FOXL2	15	12	27	403.142
#167	ZHX2	15	13	28	1778.875
#168	IRF1	15	13	28	945.593
#169	TAL1	15	19	34	1619.729
#170	HOXB2	15	13	28	1271.737
#171	LZTS1	15	12	27	1256.872
#172	HNF1B	15	16	31	635.94
#173	TBX2	15	11	26	555.283
#174	SIX1	15	13	28	758.821
#175	AHCTF1	15	15	30	681.623
#176	RFX3	15	20	35	1629.368
#177	TBX19	15	15	30	1312.402
#178	BLZF1	15	9	24	1126.442
#179	POU2F2	15	10	25	893.51
#180	CNOT7	15	20	35	1967.543
#181	ZNF90	15	15	30	1948.958
#182	SMAD4	15	14	29	1541.507
#183	ZNF165	15	14	29	1030.347
#184	MITF	15	12	27	1238.269
#185	EHF	15	17	32	954.447
#186	ZNF193	14	14	28	1284.846
#187	ZSCAN20	14	11	25	858.879
#188	HCFC1	14	16	30	1213.809
#189	PBX4	14	11	25	383.042
#190	HHEX	14	12	26	1018.622
#191	GCM1	14	14	28	1055.937
#192	TBX5	14	11	25	1527.445
#193	RUNX3	14	17	31	1035.112
#194	HSF1	14	15	29	1253.764
#195	HNF4G	14	10	24	1410.299
#196	HOXC10	14	10	24	713.392
#197	ZNF155	14	15	29	985.952
#198	DLX1	14	11	25	1178.285
#199	MTA2	14	15	29	1245.357
#200	CREB5	14	14	28	1663.879
#201	FOXO6	14	15	29	1771.668
#202	RUNX1T1	14	14	28	483.007
#203	HOXA11	14	16	30	1300.872
#204	NR4A1	14	8	22	747.726
#205	KLF12	14	16	30	1339.58
#206	NR3C2	14	18	32	1318.507
#207	HNF4A	14	12	26	873.149
#208	SP1	14	17	31	1187.775
#209	POU2F1	13	17	30	1288.119
#210	FOXA1	13	16	29	1984.112
#211	IRX3	13	15	28	1182.154
#212	RERE	13	12	25	913.054
#213	SIX4	13	14	27	1401.403
#214	CBL	13	12	25	408.733
#215	ZIC3	13	19	32	2042.445
#216	ZNF167	13	18	31	1091.874
#217	PRRX2	13	16	29	919.818
#218	HEY2	13	15	28	1582.82
#219	OLIG2	13	16	29	2365.262
#220	NEUROG1	13	16	29	1202.794
#221	NR4A2	13	10	23	1155.9
#222	MKX	13	20	33	2890.094
#223	ANKRD30A	13	15	28	1187.969
#224	PROX1	13	16	29	1434.26
#225	DLX4	13	8	21	719.966
#226	HMGB2	13	14	27	1746.117
#227	HOXA7	13	13	26	776.099
#228	CDKN2A	13	18	31	2218.089
#229	PPARA	13	20	33	590.115
#230	HOXD4	13	15	28	1628.315
#231	TAF1B	13	17	30	1334.981
#232	ZIC1	13	16	29	1208.468
#233	ELF4	12	16	28	1073.06
#234	FOXQ1	12	17	29	1564.08
#235	RORA	12	16	28	807.431
#236	NANOG	12	9	21	829.336
#237	SREBF1	12	15	27	1174.325
#238	CREB1	12	17	29	988.01
#239	GTF2H2	12	12	24	1076.128
#240	HOXA9	12	15	27	1263.882
#241	NPAT	12	17	29	2657.266
#242	NR4A3	12	7	19	289.142
#243	ZNF45	12	18	30	1214.022
#244	EGR4	12	17	29	1093.088
#245	TFDP1	12	19	31	550.728
#246	HLF	12	18	30	1549.681
#247	LHX8	12	16	28	1444.433
#248	ZNF215	12	17	29	1018.4
#249	PKNOX1	12	14	26	1907.236
#250	E2F5	12	19	31	882.153
#251	NFX1	12	17	29	747.159
#252	TEAD1	12	16	28	954.151
#253	HMGA1	12	18	30	486.491
#254	MEF2D	11	19	30	1305.297
#255	SP140	11	16	27	1128.261
#256	SLC2A4RG	11	15	26	675.431
#257	GLI3	11	15	26	928.272
#258	STAT5B	11	17	28	1087.346
#259	FOXI1	11	18	29	1256.285
#260	STRN3	11	9	20	168.972
#261	FOXC1	11	14	25	1102.16
#262	POU3F1	11	22	33	1225.48
#263	NFATC4	11	15	26	1179.284
#264	PAX7	11	15	26	1098.709
#265	ZNF483	11	15	26	1395.886
#266	ETV2	11	13	24	693.36
#267	SPIC	11	14	25	1339.967
#268	NR1I2	11	12	23	1073.226
#269	SMAD6	11	18	29	1066.425
#270	NEUROD1	11	17	28	1182.227
#271	TCF7L2	11	15	26	496.185
#272	ZNF24	11	11	22	864.535
#273	ATF2	11	14	25	1523.66
#274	HIF3A	11	18	29	1944.284
#275	ZNF71	11	17	28	634.995
#276	KLF15	11	13	24	844.845
#277	HOXD11	11	12	23	127.725
#278	BCL11B	11	9	20	442.879
#279	FOXG1	11	14	25	1349.88
#280	OVOL1	11	13	24	389.132
#281	SOX6	11	15	26	1010.421
#282	SP3	11	15	26	1133.338
#283	ELF5	11	18	29	1219.64
#284	MYCN	11	11	22	766.944
#285	GATA3	11	21	32	1082.335
#286	SOX21	11	16	27	938.41
#287	ZNF643	11	17	28	995.436
#288	ZSCAN23	11	12	23	686.957
#289	MESP1	11	17	28	908.472
#290	HOXC13	10	16	26	526.237
#291	ZNF117	10	19	29	501.735
#292	ONECUT2	10	15	25	738.923
#293	BHLHE41	10	17	27	896.766
#294	SOX11	10	13	23	737.004
#295	MEIS1	10	11	21	802.874
#296	HSF5	10	17	27	1346.601
#297	ETV4	10	16	26	674.94
#298	TFCP2L1	10	15	25	1284.415
#299	IKZF3	10	21	31	1546.501
#300	ZNF93	10	17	27	695.08
#301	MYCL1	10	14	24	802.407
#302	NPAS2	10	17	27	997.937
#303	GATAD1	10	15	25	1411.951
#304	ZXDC	10	20	30	1141.203
#305	ETV7	10	13	23	671.951
#306	SPIB	10	11	21	529.945
#307	TBX20	10	16	26	1630.105
#308	GAS7	10	15	25	663.008
#309	SIN3A	10	17	27	9072.028
#310	FOXO1	10	18	28	1450.303
#311	NKX2-8	10	12	22	655.222
#312	MEIS3	10	14	24	736.736
#313	FOSL2	10	13	23	627.307
#314	ZNF444	10	14	24	382.758
#315	AR	10	17	27	1154.056
#316	ATOH1	10	17	27	1355.44
#317	GATAD2B	10	18	28	990.605
#318	GATA5	10	11	21	686.104
#319	GSC2	10	13	23	686.82
#320	ZNF33B	10	16	26	967.692
#321	ATF3	10	6	16	176.268
#322	PHOX2B	10	16	26	1613.481
#323	ZNF174	10	12	22	969.478
#324	ZSCAN12	10	15	25	575.427
#325	PGR	10	19	29	1376.396
#326	NR1I3	10	16	26	1288.69
#327	NR5A1	10	14	24	1642.506
#328	PPARD	9	14	23	783.145
#329	NR6A1	9	16	25	1609.92
#330	TFE3	9	13	22	465.582
#331	HOXC9	9	10	19	1343.228
#332	NRL	9	13	22	469.913
#333	ELK1	9	14	23	758.491
#334	ZNF91	9	11	20	1367.893
#335	TAF4	9	14	23	759.934
#336	NFIA	9	15	24	810.921
#337	FOXN4	9	10	19	755.025
#338	CREB3L2	9	14	23	870.055
#339	SLC26A3	9	13	22	1455.924
#340	ZNF207	9	15	24	715.02
#341	ZNF154	9	13	22	751.484
#342	SIX2	9	15	24	537.382
#343	MXD1	9	15	24	548.529
#344	ZSCAN18	9	15	24	1253.066
#345	ZIC5	9	10	19	580.363
#346	THRA	9	14	23	904.608
#347	RUNX2	9	14	23	963.672
#348	ZNF287	9	15	24	885.693
#349	ELK4	9	14	23	890.691
#350	IRX5	9	8	17	426.279
#351	NEUROD2	9	21	30	1220.935
#352	ZSCAN4	9	18	27	1371.168
#353	ZEB1	9	19	28	811.482
#354	CBFA2T2	9	18	27	1403.746
#355	HOXD13	9	14	23	1158.463
#356	MESP2	9	16	25	433.473
#357	NR1H4	9	19	28	952.647
#358	DMBX1	9	11	20	768.793
#359	POU1F1	9	20	29	1239.55
#360	FOXH1	8	14	22	738.378
#361	POU6F2	8	19	27	987.463
#362	TBX22	8	15	23	1409.156
#363	NFE2	8	15	23	704.672
#364	PAX8	8	19	27	914.05
#365	SMAD5	8	11	19	308.99
#366	RARB	8	15	23	609.248
#367	CREBZF	8	15	23	1742.485
#368	MYF5	8	14	22	873.288
#369	FOXC2	8	16	24	672.694
#370	TBX4	8	13	21	768.28
#371	PURB	8	13	21	760.032
#372	ZFHX2	8	15	23	1655.661
#373	PRDM2	8	17	25	734.321
#374	HES6	8	13	21	578.133
#375	ZNF75D	8	12	20	596.522
#376	ZNF135	8	15	23	550.45
#377	HNRNPAB	8	19	27	1065.115
#378	CREBBP	8	20	28	791.319
#379	MSX2	8	13	21	740.913
#380	GATA4	8	15	23	866.551
#381	DLX2	8	9	17	413.218
#382	ZNF148	8	11	19	841.393
#383	PBX3	8	13	21	664.483
#384	ZNF19	8	12	20	578.723
#385	NANOGNB	8	16	24	762.302
#386	C11orf9	8	12	20	501.874
#387	CREB3L3	8	17	25	699.044
#388	DLX3	8	15	23	611.951
#389	ASCL1	8	16	24	1097.344
#390	PLSCR1	8	15	23	666.025
#391	HOXD3	8	18	26	953.425
#392	MYT1	8	13	21	576.556
#393	ZKSCAN3	8	16	24	1172.397
#394	ZNF197	8	20	28	1209.818
#395	RUNX1	8	12	20	755.288
#396	ARNT2	8	19	27	1581.621
#397	POU4F1	8	16	24	762.649
#398	ATF6B	8	16	24	1002.041
#399	PGBD1	8	20	28	1834.446
#400	ISX	8	18	26	622.652
#401	PHTF1	8	12	20	532.804
#402	TRERF1	8	18	26	656.648
#403	BARX1	7	15	22	568.174
#404	ARX	7	17	24	1133.878
#405	SOX5	7	18	25	1078.878
#406	GSX1	7	8	15	341.799
#407	MNX1	7	16	23	714.544
#408	ZNF446	7	15	22	631.374
#409	RARG	7	14	21	561.906
#410	ESR2	7	18	25	1503.9
#411	LHX6	7	19	26	1012.689
#412	EN2	7	13	20	279.917
#413	ZNF202	7	16	23	378.951
#414	SIM1	7	15	22	1014.312
#415	ONECUT1	7	19	26	811.849
#416	ZNF131	7	13	20	390.448
#417	TSHZ2	7	14	21	341.898
#418	POU3F2	7	15	22	754.808
#419	MEOX1	7	19	26	914.886
#420	POU4F3	7	13	20	706.326
#421	ZNF92	7	13	20	651.413
#422	FOXK1	7	10	17	364.067
#423	ISL1	7	17	24	899.2
#424	WT1	7	11	18	271.647
#425	SNAPC5	7	14	21	627.865
#426	LHX9	7	13	20	770.722
#427	CUX2	7	18	25	1027.608
#428	PTH	7	21	28	895.049
#429	LMO4	7	14	21	268.846
#430	HOXD1	7	14	21	462.022
#431	NKX3-2	7	18	25	743.92
#432	HMG20B	7	15	22	640.42
#433	SMAD2	7	15	22	609.587
#434	RXRG	6	14	20	445.87
#435	ZNF81	6	13	19	740.816
#436	TFAP2B	6	17	23	539.409
#437	NPAS1	6	16	22	473.497
#438	GBX2	6	17	23	678.644
#439	HIRA	6	16	22	1005.37
#440	NCOR1	6	14	20	591.765
#441	RCAN1	6	17	23	1333.778
#442	CREM	6	14	20	358.175
#443	FOXL1	6	14	20	641.82
#444	ST18	6	13	19	431.048
#445	ZNF397	6	18	24	390.394
#446	EVX1	6	15	21	1373.393
#447	TADA3	6	17	23	353.171
#448	VSX1	6	17	23	597.548
#449	BRD8	6	12	18	631.276
#450	MECOM	6	19	25	516.851
#451	NKX2-3	6	14	20	382.212
#452	NKX6-2	6	15	21	857.898
#453	ESRRB	6	18	24	868.864
#454	OTX2	6	20	26	684.413
#455	ZFP42	5	17	22	461.125
#456	TEF	5	16	21	576.864
#457	SOX1	5	22	27	703.059
#458	ALS2CR8	5	10	15	234.46
#459	ZNF41	5	16	21	440.394
#460	MAF	5	18	23	601.854
#461	MLL	5	15	20	375.394
#462	IRX2	5	23	28	429.884
#463	SOX30	5	14	19	573.235
#464	IRF4	5	13	18	395.747
#465	NFYC	5	14	19	281.317
#466	ESRRG	5	19	24	1062.446
#467	HOXA2	5	14	19	638.144
#468	MLLT10	5	17	22	499.58
#469	ISL2	5	20	25	300.575
#470	TFAP2D	4	13	17	424.828
#471	TAF13	4	19	23	425.853
#472	FOXP3	4	19	23	565.726
#473	ZNF396	4	16	20	235.678
#474	RORB	4	21	25	716.802
#475	TLX2	4	13	17	341.446
#476	FOXP1	4	19	23	380.866
#477	MYT1L	4	16	20	563.261
#478	ZNF449	4	13	17	743.192
#479	SCAND2	4	16	20	372.997
#480	PPARG	4	18	22	386.383
#481	TLX3	4	23	27	476.52
#482	TFEC	4	17	21	363.277
#483	HOXB9	4	16	20	462.279
#484	ZNF157	4	17	21	434.463
#485	POU2F3	4	19	23	495.273
#486	ZBTB38	4	18	22	431.749
#487	ZNF80	3	15	18	383.002
#488	MGA	3	20	23	580.081
#489	ZNF500	3	15	18	975.943
#490	TP73	3	13	16	233.328
#491	FOXD3	2	18	20	301.679
#492	PAX3	2	15	17	214.366
#493	FLI1	2	19	21	269.908
#494	FOXO3	2	15	17	207.445
#495	HMGA2	2	17	19	297.894
#496	SIX3	2	17	19	132.517
#497	TSC22D2	1	17	18	109.798
#498	ESX1	1	20	21	82.947
#499	MYNN	1	22	23	97.299
#500	ZFP36L1	0	14	14	0