Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	NFKB2	106	1	107	8.149
#2	NEUROD1	99	1	100	25.281
#3	NR2E1	85	5	90	150.268
#4	SCAND2	85	2	87	22.593
#5	LZTS1	84	2	86	12.411
#6	NR1H4	69	4	73	54.897
#7	FOXP3	68	6	74	104.835
#8	TAL1	61	6	67	87.374
#9	NRL	58	9	67	246.431
#10	NPAT	58	5	63	197.451
#11	LHX1	53	11	64	286.083
#12	FOXC1	48	6	54	3717.498
#13	HMGA2	47	5	52	223.995
#14	NFAT5	47	4	51	445.447
#15	IKZF3	46	10	56	366.337
#16	FOXA1	46	6	52	1933.179
#17	GBX2	45	7	52	116.717
#18	LHX3	43	8	51	141.624
#19	HCFC1	42	10	52	894.348
#20	DBP	40	3	43	934.389
#21	ESR1	40	7	47	1082.161
#22	ZKSCAN4	40	8	48	244.891
#23	XBP1	39	2	41	1054.608
#24	TBX2	38	10	48	3786.489
#25	ZSCAN5A	37	7	44	149.161
#26	LHX2	36	7	43	2373.811
#27	SPDEF	35	5	40	203.52
#28	T	35	9	44	6311.824
#29	GATA3	35	4	39	1773.781
#30	TCF3	34	4	38	2816.304
#31	TAF4B	33	10	43	645.271
#32	NKX2-8	33	10	43	578.03
#33	PAX3	33	9	42	110.275
#34	MMP14	33	9	42	320.675
#35	LHX5	33	7	40	45.557
#36	RORA	31	10	41	512.059
#37	ARNTL2	31	7	38	903.233
#38	KLF1	30	11	41	234.609
#39	NKX2-5	30	9	39	274.162
#40	CCRN4L	30	8	38	18717.148
#41	TAF1B	30	9	39	366.909
#42	TBX21	30	8	38	1151.342
#43	JUN	29	10	39	359.271
#44	HOXD9	29	10	39	732.087
#45	ATF1	28	18	46	1979.862
#46	MLL	28	10	38	1715.585
#47	YBX1	28	6	34	1549.574
#48	VDR	28	6	34	249.646
#49	SRY	27	10	37	996.272
#50	NR6A1	27	4	31	14.402
#51	MEIS2	27	12	39	5619.267
#52	TBX1	27	4	31	42.386
#53	FOXM1	27	12	39	3534.404
#54	KLF12	26	7	33	5470.046
#55	RUNX1T1	26	10	36	6760.226
#56	PBX2	26	10	36	4946.231
#57	ELK4	26	8	34	207.217
#58	SIX3	26	9	35	13969.468
#59	ZNF174	26	6	32	33291.001
#60	TFE3	26	19	45	1493.618
#61	EN2	25	7	32	72.778
#62	SOX10	25	5	30	232.014
#63	SNAPC4	25	8	33	3080.987
#64	EGR1	25	5	30	768.397
#65	EN1	25	10	35	5295.412
#66	HNF1B	25	4	29	7852.386
#67	GATAD2A	24	10	34	1258.394
#68	SMAD2	24	7	31	124.463
#69	ETV6	24	10	34	523.755
#70	ZNF287	24	10	34	272.628
#71	MYT1L	24	3	27	8.655
#72	FOXO1	24	11	35	310.917
#73	RXRB	24	8	32	236.293
#74	HCLS1	24	2	26	1793.726
#75	VTN	23	8	31	1072.374
#76	TCF7L1	23	11	34	6404.901
#77	NFIC	23	14	37	6040.277
#78	E2F1	23	10	33	817.502
#79	TFAP4	22	8	30	739.84
#80	TSC22D3	22	11	33	184.264
#81	MYNN	22	12	34	2637.819
#82	MEF2D	21	8	29	173.659
#83	SPI1	21	10	31	1546.814
#84	CNOT8	21	11	32	413.422
#85	PDX1	21	11	32	212.239
#86	ZNF35	20	8	28	662.305
#87	FUBP1	20	11	31	215.576
#88	THRB	20	8	28	1095.694
#89	MEIS3P1	20	13	33	1440.862
#90	CREB1	20	14	34	1908.736
#91	MYBL2	20	14	34	3507.967
#92	SMAD1	20	11	31	1852.351
#93	LMO4	20	16	36	2491.667
#94	AFF1	20	15	35	1219.951
#95	E2F3	19	14	33	4906.966
#96	PTTG1	19	9	28	823.112
#97	TCF7L2	19	16	35	2009.817
#98	ATF6B	19	8	27	34674.978
#99	SIX6	19	7	26	638.934
#100	GAS7	19	10	29	1987.57
#101	FOXG1	19	12	31	1502.339
#102	ARNT	19	10	29	1494.069
#103	ELK1	19	11	30	2473.258
#104	ADNP2	19	11	30	847.526
#105	TWIST1	19	11	30	1424.308
#106	MEOX2	18	8	26	1541.379
#107	PAX8	18	7	25	122.629
#108	NOLC1	18	14	32	13016.117
#109	FOXL1	18	5	23	72.774
#110	TFAM	18	13	31	1433.978
#111	STAT4	18	12	30	1856.955
#112	NANOG	18	14	32	1673.369
#113	ONECUT2	18	13	31	572.057
#114	FOXF2	18	12	30	731.538
#115	ZNF45	18	10	28	466.101
#116	E2F8	18	12	30	9225.728
#117	ENO1	17	12	29	1236.444
#118	NR2C2	17	12	29	221.52
#119	BHLHE40	17	13	30	4085.933
#120	NFIB	17	10	27	1440.786
#121	DMTF1	17	11	28	927.159
#122	RUNX1	17	16	33	4785.627
#123	ELK3	17	10	27	1841.245
#124	BTG2	17	16	33	6289.408
#125	MEIS1	17	17	34	1689.854
#126	MZF1	16	11	27	1367.608
#127	FOXN1	16	11	27	906.992
#128	IRF5	16	18	34	1222.045
#129	AR	16	14	30	3985.3
#130	CREBBP	16	6	22	65.034
#131	TADA2A	16	9	25	1433.293
#132	NR3C1	16	13	29	1213.244
#133	GLI2	16	12	28	2705.81
#134	SMAD6	16	8	24	168.559
#135	JUND	16	13	29	988.834
#136	POU6F1	16	10	26	113.109
#137	HDAC2	16	19	35	22265.784
#138	CREM	16	12	28	563.488
#139	IRF8	16	5	21	2435.379
#140	NPAS1	16	9	25	316.151
#141	ZFP37	15	11	26	135.157
#142	ZFHX4	15	15	30	2998.228
#143	TRIM25	15	9	24	162.474
#144	NFIX	15	15	30	1622.408
#145	MSRB2	15	13	28	610.382
#146	ZNF133	15	8	23	180.615
#147	FOS	15	5	20	186.331
#148	CSDA	15	15	30	1730.532
#149	RARG	15	9	24	62.317
#150	PURA	15	13	28	36433.871
#151	CEBPB	15	13	28	975.117
#152	SP4	14	11	25	688.468
#153	SOX4	14	19	33	1609.054
#154	OLIG2	14	8	22	90.556
#155	SOX5	14	11	25	119.839
#156	BACH2	14	12	26	4083.622
#157	ZNF175	14	10	24	7774.851
#158	KDM5A	14	11	25	812.699
#159	NPAS2	14	11	25	741.134
#160	CREB5	13	10	23	99.089
#161	CREBL2	13	14	27	4432.441
#162	RARB	13	12	25	1577.072
#163	ZNF24	13	11	24	2599.931
#164	IRF1	13	10	23	1375.67
#165	TCF15	13	9	22	215.755
#166	ZNF187	13	13	26	1403.573
#167	KLF2	13	13	26	1381.419
#168	ZNF154	13	6	19	25.164
#169	SOX11	13	17	30	3563.012
#170	IRF2	13	6	19	102.16
#171	ZKSCAN5	13	10	23	724.023
#172	HOXA5	13	10	23	2276.648
#173	MEF2C	13	8	21	1338.182
#174	PRDM2	13	7	20	241.865
#175	E4F1	13	11	24	2109.621
#176	ZEB2	13	15	28	1943.342
#177	HMG20A	13	17	30	10053.376
#178	ALX1	13	13	26	7859.331
#179	HNF1A	13	12	25	242.488
#180	CREB3L1	12	10	22	2486.961
#181	NR4A1	12	12	24	494.808
#182	TP63	12	8	20	407.085
#183	GTF2H3	12	13	25	111.798
#184	REL	12	10	22	2155.012
#185	TFEC	12	8	20	2620.049
#186	MAF	12	9	21	868.353
#187	MEOX1	12	7	19	344.59
#188	MAX	12	9	21	426.689
#189	IRF4	12	7	19	642.94
#190	SMAD4	12	14	26	3198.968
#191	RERE	12	20	32	2038.768
#192	RBPJ	12	11	23	503.566
#193	REST	12	12	24	240.12
#194	ELF2	12	9	21	2574.386
#195	GTF2H4	12	15	27	2214.327
#196	CSRNP2	12	12	24	1958.537
#197	LZTR1	12	10	22	103.456
#198	PHF1	12	11	23	35383.503
#199	ZNF500	12	12	24	4004.27
#200	RUNX2	12	12	24	88.176
#201	GABPB1	12	8	20	649.869
#202	STAT2	12	8	20	189.617
#203	SCML2	11	16	27	168.612
#204	SNAI2	11	16	27	3863.61
#205	JUNB	11	9	20	3630.232
#206	STRN3	11	12	23	94.267
#207	KLF11	11	17	28	2580.402
#208	STAT5A	11	13	24	4359.477
#209	ETV1	11	17	28	535.131
#210	FOXJ3	11	11	22	285.848
#211	MTA2	11	9	20	70.072
#212	NFYB	11	14	25	2291.056
#213	LASS2	11	17	28	3099.316
#214	ZNF189	11	14	25	2088.323
#215	MAFG	11	13	24	310.02
#216	CIR1	10	12	22	293.078
#217	ZEB1	10	17	27	1422.659
#218	BRD8	10	11	21	319.026
#219	HIF3A	10	11	21	110.263
#220	PCGF2	10	21	31	3032.468
#221	ZKSCAN1	10	17	27	468.359
#222	SCAND1	10	16	26	1320.43
#223	GTF2I	10	14	24	2526.891
#224	MAFB	10	12	22	2040.066
#225	STAT1	10	7	17	1532.516
#226	TEAD3	10	11	21	163.971
#227	NR2F6	10	22	32	4358.644
#228	LHX6	10	16	26	8925.357
#229	FOSB	10	5	15	585.304
#230	MYCN	10	12	22	309.566
#231	HES1	10	13	23	2051.723
#232	BHLHE41	10	24	34	3544.175
#233	ELF5	10	13	23	921.557
#234	KLF5	10	12	22	3602.467
#235	POU2F1	10	12	22	1249.427
#236	TRIM28	10	23	33	2656.078
#237	E2F4	10	7	17	1805.615
#238	ATF6	9	12	21	681.1
#239	NR4A3	9	12	21	2287.652
#240	EPAS1	9	9	18	5810.83
#241	NFE2L1	9	10	19	436.191
#242	TCEAL1	9	10	19	669.386
#243	SLC2A4RG	9	18	27	1297.775
#244	ERG	9	10	19	440.586
#245	TAF4	9	14	23	933.211
#246	ELF1	9	15	24	290.917
#247	RXRA	9	12	21	2749.328
#248	CDKN2A	9	10	19	1035.953
#249	LASS6	9	13	22	1747.064
#250	NOTCH1	9	12	21	890.24
#251	ZNF167	9	13	22	318.437
#252	ATF5	9	18	27	442.283
#253	ZNF263	9	11	20	33597.182
#254	NFATC3	9	17	26	2309.175
#255	TRIM29	9	13	22	897.707
#256	FOXA2	9	13	22	210.693
#257	ZFP36L1	9	13	22	1080.06
#258	BLZF1	9	12	21	1225.968
#259	PA2G4	9	11	20	1274.744
#260	NR1H2	9	12	21	617.337
#261	MLLT10	9	15	24	1672.144
#262	UBN1	9	10	19	9276.635
#263	MSC	8	12	20	106.015
#264	PHTF1	8	9	17	64.184
#265	CBFB	8	13	21	2264.552
#266	SOX13	8	18	26	1815.736
#267	CUX1	8	14	22	152.36
#268	HOXD1	8	9	17	88.866
#269	MTA1	8	18	26	1313.596
#270	C2orf3	8	17	25	1426.742
#271	TGIF2	8	18	26	2672.578
#272	NFATC1	8	19	27	1225.79
#273	THRA	8	10	18	506.947
#274	POU4F3	8	12	20	330.804
#275	WNT5A	8	20	28	1775.561
#276	GATA6	8	20	28	902.67
#277	TCF25	8	13	21	638.581
#278	MSX1	8	15	23	231.966
#279	ZNF75D	8	15	23	1937.798
#280	HLF	8	14	22	688.409
#281	STAT6	8	12	20	4844.425
#282	SIX2	7	24	31	3069.615
#283	FLI1	7	10	17	1171.513
#284	ARNT2	7	18	25	3869.026
#285	RCAN1	7	17	24	899.7
#286	KLF6	7	19	26	5848.528
#287	RFXANK	7	13	20	565.916
#288	HEY2	7	12	19	13822.776
#289	SCML1	7	13	20	348.638
#290	TAF10	7	16	23	2293.47
#291	BCL6	7	9	16	109.374
#292	ZSCAN16	7	11	18	508.221
#293	TCF4	7	15	22	1543.158
#294	HSF1	7	14	21	710.267
#295	FOXK2	7	12	19	1204.408
#296	AHCTF1	7	15	22	2406.485
#297	HOXD3	7	15	22	496.256
#298	HOXA10	7	15	22	239.718
#299	HOXA9	7	12	19	718.272
#300	NFYA	7	8	15	74.106
#301	HNRNPAB	7	18	25	854.237
#302	ZBTB48	7	9	16	112.748
#303	GLI3	7	19	26	1347.756
#304	NFKB1	7	12	19	1362.241
#305	TULP4	7	16	23	912.603
#306	NR2F2	7	17	24	1998.645
#307	AATF	7	17	24	142.06
#308	ETS2	7	12	19	943.473
#309	NCOR1	7	12	19	424.805
#310	TRIM22	7	12	19	1093.077
#311	SUPT6H	7	17	24	886.768
#312	EHF	7	23	30	2049.053
#313	DRAP1	7	12	19	1140.506
#314	HMGA1	7	12	19	306.412
#315	TCF7	7	16	23	168.858
#316	ZSCAN18	6	20	26	2793.742
#317	MECOM	6	15	21	2408.599
#318	ELF3	6	18	24	713.485
#319	PLSCR1	6	15	21	575.223
#320	HOXD4	6	13	19	99.339
#321	HOXB2	6	20	26	1243.022
#322	NR1H3	6	10	16	897.124
#323	NFYC	6	13	19	277.622
#324	TFCP2L1	6	11	17	69.798
#325	SMAD3	6	15	21	386.348
#326	NFIL3	6	17	23	1159.975
#327	KDM5B	6	23	29	1783.492
#328	HMGB2	6	17	23	5011.654
#329	ZNF281	6	12	18	1659.856
#330	ZNF93	6	15	21	24574.372
#331	RARA	6	20	26	4381.945
#332	IRX5	6	17	23	1505.444
#333	HOXB7	6	16	22	1896.543
#334	GABPA	6	13	19	3187.373
#335	SREBF2	6	15	21	205.369
#336	PBX1	6	14	20	226.769
#337	TARDBP	6	15	21	532.636
#338	ELF4	6	15	21	828.576
#339	YEATS4	6	14	20	579.607
#340	STAT5B	6	16	22	275.336
#341	EGR2	6	14	20	1796.287
#342	SOLH	6	15	21	5954.906
#343	ZNF3	6	12	18	964.637
#344	HIF1A	6	26	32	3754.285
#345	MITF	6	12	18	1107.637
#346	ESRRG	6	16	22	2360.539
#347	ZHX2	6	18	24	1271.512
#348	ATF3	6	9	15	230.531
#349	NR2F1	6	17	23	254.43
#350	ZNF238	6	19	25	2706.877
#351	EGR3	6	11	17	2639.744
#352	SP3	6	14	20	951.854
#353	NR4A2	6	19	25	2579.121
#354	HEY1	6	16	22	2162.502
#355	ASCL1	6	16	22	2486.778
#356	YY1	6	13	19	3404.195
#357	HOXC10	6	17	23	2329.759
#358	SPIB	5	16	21	1173.855
#359	BTAF1	5	20	25	411.334
#360	ADNP	5	14	19	536.454
#361	TSC22D1	5	19	24	889.33
#362	WT1	5	18	23	734.776
#363	TBX3	5	16	21	1124.357
#364	FOXD1	5	17	22	2950.753
#365	RBCK1	5	10	15	493.513
#366	SOX12	5	18	23	1614.32
#367	NR1D2	5	12	17	153.383
#368	PPARD	5	19	24	436.336
#369	GATA4	5	14	19	1771.918
#370	STAT3	5	14	19	719.337
#371	AEBP1	5	18	23	1374.834
#372	TRPS1	5	17	22	1207.029
#373	NFE2L3	5	14	19	525.014
#374	GCM1	5	13	18	7703.751
#375	PEG3	5	25	30	2073.417
#376	FOXN3	5	15	20	693.978
#377	ZFPM2	5	15	20	3903.223
#378	POU3F1	5	7	12	1897.24
#379	ZBTB38	5	14	19	660.227
#380	ZNF135	5	16	21	670.457
#381	GCFC1	5	11	16	139.15
#382	CTCF	5	9	14	66.09
#383	ZFHX3	5	14	19	4832.749
#384	TSC22D2	5	14	19	1192.062
#385	IRX4	5	14	19	935.894
#386	HOXC11	5	11	16	1626.382
#387	SMAD5	5	19	24	673.914
#388	CNOT7	5	14	19	668.516
#389	IRF7	5	17	22	1430.123
#390	ZNF165	5	15	20	1270.483
#391	PPARG	4	14	18	3251.873
#392	NFX1	4	12	16	67.837
#393	NFATC4	4	15	19	584.051
#394	SOX18	4	12	16	625.341
#395	IRF9	4	11	15	620.163
#396	GATAD1	4	14	18	395.774
#397	CITED2	4	24	28	565.56
#398	MYC	4	20	24	413.842
#399	PGR	4	18	22	2504.422
#400	KLF4	4	18	22	557.823
#401	RFX5	4	17	21	244.885
#402	CUX2	4	14	18	398.471
#403	BCL11B	4	13	17	939.16
#404	FOSL2	4	21	25	1904.122
#405	ZNF91	4	16	20	1783.744
#406	MAFF	4	17	21	1479.568
#407	IRF6	4	14	18	880.923
#408	ZNF277	4	18	22	372.805
#409	DLX4	4	9	13	248.022
#410	BATF	4	14	18	405.891
#411	NKX3-1	4	22	26	1874.183
#412	ZNF131	4	17	21	407.406
#413	RUNX3	4	20	24	2727.807
#414	CEBPD	4	22	26	404.349
#415	E2F5	4	16	20	528.555
#416	HMGB1	4	22	26	1630.212
#417	NFE2L2	4	16	20	367.931
#418	SALL2	4	16	20	2078.334
#419	ZFP36L2	4	17	21	1192.587
#420	HIRA	4	24	28	1170.639
#421	CREBZF	4	13	17	99.52
#422	ZNF394	4	12	16	93.821
#423	CREB3L2	4	20	24	313.938
#424	TCF20	4	16	20	955.691
#425	ZNF117	3	11	14	24.096
#426	ECSIT	3	9	12	3021.324
#427	ZNF85	3	10	13	43.174
#428	RCOR1	3	12	15	3377.665
#429	MYCL1	3	10	13	909.908
#430	KLF10	3	16	19	1199.937
#431	GRHL2	3	18	21	364.616
#432	SPEN	3	10	13	422.831
#433	HHEX	3	28	31	256.021
#434	AHR	3	11	14	59.958
#435	TBP	3	17	20	238.879
#436	NR2C1	3	15	18	150.196
#437	KLF7	3	17	20	566.606
#438	SNAPC5	3	14	17	38.389
#439	ETV5	3	13	16	124.036
#440	CBFA2T3	3	13	16	545.726
#441	ZIC1	3	21	24	3865.187
#442	TGIF1	3	11	14	60.895
#443	MSX2	3	18	21	156.724
#444	EDF1	3	14	17	1055.717
#445	ARNTL	3	14	17	1272.529
#446	CEBPA	3	16	19	472.318
#447	ZNF83	3	17	20	1047.044
#448	HOXB6	3	10	13	1512.629
#449	PRRX1	3	14	17	1837.328
#450	DLX2	3	21	24	3268.536
#451	TFAP2C	3	18	21	1142.487
#452	SATB1	3	21	24	997.949
#453	HOXB5	3	17	20	164.218
#454	TP53	3	15	18	331.171
#455	HMG20B	3	17	20	429.527
#456	RB1	3	21	24	1108.077
#457	TCF12	3	14	17	1706.696
#458	TFDP1	3	15	18	3139.404
#459	SATB2	3	16	19	78.368
#460	TCFL5	3	14	17	107.368
#461	CITED1	3	20	23	2778.703
#462	SLC30A9	3	14	17	105.648
#463	TAF7	2	11	13	151.435
#464	FOXO3	2	17	19	284.173
#465	SREBF1	2	17	19	301.881
#466	HOPX	2	21	23	279.777
#467	HMBOX1	2	11	13	446.112
#468	ZNF140	2	17	19	760.375
#469	SUPT4H1	2	12	14	83.11
#470	BCL3	2	15	17	3409.573
#471	BUD31	2	9	11	137.422
#472	BACH1	2	16	18	436.165
#473	ZNF323	2	24	26	1170.216
#474	SOX9	2	23	25	334.271
#475	MEF2A	2	20	22	7946.495
#476	SLC26A3	2	19	21	590.817
#477	SIX1	2	18	20	1303.835
#478	ZNF148	2	14	16	3153.296
#479	TFDP2	2	11	13	24.634
#480	TAF12	2	10	12	42.19
#481	HOXC4	2	11	13	293.522
#482	ZNF274	2	20	22	2871.191
#483	FOXI1	1	19	20	2926.524
#484	CTNNB1	1	20	21	57.776
#485	NR3C2	1	21	22	36.346
#486	PBX3	1	26	27	56.192
#487	SIM2	1	15	16	87.646
#488	KLF9	1	21	22	143.584
#489	TEAD4	1	10	11	18.163
#490	HDAC1	1	15	16	64.534
#491	ZNF268	1	17	18	33.013
#492	ZNF232	1	22	23	174.67
#493	GATA2	1	17	18	56.527
#494	ZNF217	0	25	25	0
#495	ATF2	0	14	14	0
#496	CTBP1	0	19	19	0
#497	PITX1	0	30	30	0
#498	TFAP2B	0	28	28	0
#499	TFAP2A	0	18	18	0
#500	LEF1	0	22	22	0