Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	MITF	76	5	81	2701.274
#2	ETS1	68	6	74	788.675
#3	ZEB2	64	5	69	706.786
#4	MAFF	63	8	71	993.921
#5	FOSL1	58	6	64	451.387
#6	ETV4	57	3	60	445.632
#7	KLF5	53	15	68	3644.272
#8	ETV5	53	11	64	894.162
#9	SPDEF	52	3	55	218.959
#10	SNAI2	49	9	58	906.32
#11	ZFHX3	48	6	54	1306.17
#12	CREB3L4	47	6	53	267.056
#13	ELF3	47	8	55	1433.964
#14	NR1H3	46	12	58	2093.98
#15	ELK3	46	6	52	495.669
#16	HEY1	45	15	60	2060.456
#17	NR3C1	43	14	57	1536.528
#18	EPAS1	43	15	58	3463.067
#19	ASCL2	42	12	54	1854.633
#20	ZSCAN16	41	8	49	1239.771
#21	ZNF165	40	5	45	527.137
#22	TEAD1	40	9	49	476.166
#23	ARNTL2	39	12	51	796.39
#24	CBFA2T3	39	6	45	436.963
#25	IRX3	39	8	47	2480.443
#26	MLXIPL	39	9	48	1316.57
#27	HCLS1	38	6	44	715.854
#28	FOXQ1	38	14	52	1830.563
#29	IRF4	38	6	44	2103.733
#30	MEF2C	38	14	52	3275.833
#31	HOXA3	37	15	52	1164.62
#32	ARNT2	37	10	47	3283.674
#33	VAV1	37	12	49	1702.538
#34	CEBPA	37	10	47	1102.88
#35	IRF6	37	1	38	253.108
#36	ELF1	36	7	43	855.029
#37	SOX5	36	6	42	290.46
#38	FOXD1	36	17	53	2950.061
#39	FOXA1	36	12	48	1137.116
#40	TFAP2A	35	14	49	2966.526
#41	EBF1	34	10	44	889.062
#42	DLX1	34	12	46	2265.367
#43	GATA6	34	15	49	1352.25
#44	CSRNP1	34	16	50	1832.952
#45	GAS7	33	6	39	231.798
#46	SMAD3	33	11	44	635.097
#47	KLF9	33	15	48	1738.241
#48	HOXA5	32	4	36	388.152
#49	SOX13	32	9	41	1792.445
#50	HOXB6	31	4	35	400.439
#51	GRHL2	31	8	39	437.794
#52	PBX3	31	12	43	2002.127
#53	JUN	31	16	47	1337.259
#54	POU3F4	30	7	37	1105.982
#55	RUNX2	30	16	46	1183.493
#56	CITED1	30	12	42	766.622
#57	NFIX	30	13	43	1803.67
#58	FOXC1	29	11	40	1438.268
#59	RELB	29	12	41	1486.575
#60	BCL11B	29	10	39	1105.628
#61	LEF1	29	13	42	1547.813
#62	FOSL2	29	7	36	735.311
#63	SOX10	29	7	36	252.72
#64	TCF7	29	18	47	1776.349
#65	BCL3	29	13	42	3117.088
#66	CEBPD	28	14	42	1650.977
#67	LZTS1	28	12	40	2810.884
#68	GLIS3	28	10	38	563.016
#69	NFIB	28	10	38	1549.563
#70	SIX1	27	12	39	845.081
#71	IKZF1	27	3	30	138.624
#72	SOX4	27	9	36	1345.232
#73	BATF	27	14	41	3306.112
#74	FOS	27	10	37	824.085
#75	SNAI3	26	13	39	670.954
#76	PAX8	26	12	38	1701.183
#77	EHF	26	8	34	276.353
#78	TCF15	26	18	44	3063.09
#79	GATA3	26	11	37	475.146
#80	ZFP36L1	26	19	45	4261.984
#81	PLSCR1	26	15	41	2873.703
#82	BCL6	26	15	41	1860.491
#83	FOXO1	25	16	41	933.025
#84	E2F2	25	8	33	752.645
#85	HOXC9	25	15	40	1871.532
#86	TRERF1	25	10	35	1010.108
#87	TEAD4	25	4	29	347.392
#88	FOXN3	25	19	44	4106.648
#89	BHLHE40	25	19	44	2139.804
#90	HNF1A	25	9	34	1215.068
#91	RFXAP	25	11	36	655.043
#92	TBX2	25	18	43	1075.919
#93	RCAN1	24	16	40	1282.866
#94	STAT5A	24	9	33	977.565
#95	SIX4	24	24	48	2100.623
#96	MMP14	24	11	35	559.343
#97	ZBTB38	24	10	34	1385.747
#98	IRF5	24	22	46	3465.945
#99	HNF1B	23	8	31	441.77
#100	OVOL1	23	5	28	84.684
#101	TEAD3	23	19	42	795.22
#102	ZNF138	23	10	33	1065.205
#103	STAT5B	23	8	31	1228.952
#104	TFAP4	23	10	33	897.899
#105	HOXC10	23	11	34	2273.029
#106	TSHZ1	23	13	36	2496.076
#107	SOX6	23	8	31	260.761
#108	TCEAL1	23	10	33	2361.623
#109	SCML1	22	10	32	1224.926
#110	SOX9	22	16	38	1427.135
#111	PBX1	22	20	42	2139.506
#112	XBP1	22	13	35	1469.41
#113	RARG	22	16	38	2552.044
#114	HOXB5	22	7	29	289.257
#115	HHEX	22	19	41	3241.615
#116	ETS2	22	11	33	993.498
#117	MTA3	22	7	29	1318.219
#118	NR2F2	22	21	43	1544.678
#119	LHX6	21	12	33	2319.22
#120	POU5F1	21	12	33	1654.34
#121	CDX2	21	14	35	1479.884
#122	AHR	21	12	33	944.761
#123	IRX6	21	1	22	5.674
#124	IRX4	20	16	36	2424.669
#125	KLF15	20	11	31	391.245
#126	SALL2	20	15	35	1612.661
#127	IRF7	20	8	28	976.872
#128	STAT6	20	8	28	1630.391
#129	HIF1A	20	13	33	1226.118
#130	KLF3	20	14	34	1873.438
#131	PPARG	19	12	31	1193.105
#132	FOXF2	19	14	33	558.245
#133	PITX1	19	11	30	278.881
#134	HOXC8	19	9	28	1440.871
#135	ZNF71	19	13	32	1659
#136	NFIC	19	12	31	2076.557
#137	NPAS2	19	20	39	858.481
#138	KLF6	19	19	38	2123.398
#139	RXRA	19	24	43	1707.503
#140	IRF1	19	13	32	523.408
#141	CITED2	19	14	33	1250.313
#142	ZNF91	18	17	35	1401.918
#143	SCAND3	18	13	31	2189.357
#144	HOXD8	18	16	34	1071.354
#145	ETV6	18	15	33	992.905
#146	JUNB	18	16	34	1521.488
#147	DBP	18	17	35	797.619
#148	GLI3	18	18	36	960.882
#149	MEIS3P1	18	21	39	4169.235
#150	PAX3	18	14	32	1364.971
#151	ARID3A	17	16	33	1748.243
#152	C11orf9	17	18	35	1839.008
#153	BATF3	17	12	29	594.698
#154	TCF4	17	21	38	1417.094
#155	MYC	17	8	25	559.474
#156	TWIST1	17	16	33	516.412
#157	TSHZ3	17	17	34	647.377
#158	LHX2	17	12	29	1507.591
#159	MEIS1	17	15	32	1656.324
#160	MEIS2	17	10	27	1395.931
#161	ZNF134	17	11	28	456.348
#162	LASS6	17	11	28	1738.441
#163	ALX1	17	15	32	766.81
#164	TCF7L2	16	17	33	1320.049
#165	SMAD4	16	11	27	1161.762
#166	IRX5	16	13	29	582.569
#167	KLF4	16	11	27	1280.265
#168	PRRX2	16	18	34	1585.369
#169	TBX15	16	16	32	995.083
#170	RB1	16	12	28	1447.984
#171	TFDP2	16	15	31	1920.164
#172	HOXD10	16	8	24	621.341
#173	MECOM	16	15	31	1350.738
#174	FOXP1	15	19	34	919.054
#175	FLI1	15	15	30	599.171
#176	ZNF175	15	19	34	3089.818
#177	TGIF2	15	14	29	1661.554
#178	HEYL	15	18	33	1592.227
#179	MAFB	15	16	31	1418.734
#180	RHOXF2	15	9	24	929.98
#181	HOXA13	15	18	33	1445.455
#182	PBX4	15	18	33	1879.927
#183	VDR	15	18	33	1509.875
#184	FOXG1	15	15	30	571.493
#185	TEAD2	15	10	25	768.966
#186	HOXB7	15	12	27	1089.019
#187	CREB3L3	15	14	29	1933.778
#188	ZNF35	15	16	31	1331.784
#189	EGR3	14	16	30	862.389
#190	NR1D1	14	16	30	979.473
#191	EN1	14	13	27	786.548
#192	TLX2	14	11	25	1904.956
#193	HOXA4	14	20	34	1858.506
#194	ZFHX4	14	19	33	1676.758
#195	HOXB2	14	16	30	1039.29
#196	NR0B1	14	18	32	785.97
#197	NFE2	14	11	25	867.665
#198	NOTCH1	14	13	27	369.359
#199	HOXA10	14	8	22	193.684
#200	HOXA9	14	14	28	434.769
#201	HMGA2	14	13	27	393.955
#202	ETV1	14	15	29	1072.643
#203	TSC22D1	14	23	37	1003.55
#204	HEY2	13	17	30	670.035
#205	NFATC2	13	19	32	645.907
#206	MAF	13	22	35	3837.452
#207	HOXB3	13	13	26	493.585
#208	POU3F2	13	9	22	553.781
#209	LHX1	13	11	24	508.499
#210	LMO4	13	18	31	1357.04
#211	CREB3L2	13	16	29	1725.023
#212	MSC	13	16	29	1426.329
#213	NR2E3	13	19	32	2608.685
#214	FOXA2	13	11	24	651.324
#215	HOMEZ	13	15	28	1555.64
#216	NFATC1	13	14	27	1213.328
#217	SATB1	13	13	26	1036.533
#218	DLX2	13	17	30	684.668
#219	KLF12	13	18	31	1230.277
#220	NR2F1	13	20	33	2301.197
#221	ARNTL	13	14	27	1526.118
#222	FOXA3	13	14	27	742.767
#223	HMGA1	13	19	32	1032.196
#224	ONECUT2	13	20	33	2100.636
#225	CUX1	13	14	27	990.379
#226	FOXL2	13	18	31	1093.042
#227	ZNF287	13	15	28	1885.898
#228	AFF1	13	19	32	2068.237
#229	NR4A2	13	21	34	983.934
#230	DMBX1	13	19	32	2519.858
#231	PRDM1	13	18	31	1286.18
#232	ZSCAN18	12	19	31	986.995
#233	ZEB1	12	14	26	1057.845
#234	HNF4A	12	6	18	122.815
#235	HOXC13	12	17	29	814.329
#236	HOXB9	12	14	26	626.109
#237	SOX2	12	21	33	2071.972
#238	MGA	12	8	20	1217.115
#239	NKX2-5	12	19	31	2266.613
#240	MSX1	12	22	34	1206.24
#241	PGR	12	12	24	1018.758
#242	C12orf28	12	13	25	631.236
#243	TBX1	12	16	28	1208.834
#244	ELF4	12	11	23	443.191
#245	MNX1	12	17	29	1434.148
#246	HOXA7	12	13	25	883.546
#247	SMAD9	12	16	28	1370.958
#248	STRN3	12	11	23	801.189
#249	MSX2	12	9	21	1101.454
#250	THRA	11	17	28	845.591
#251	EOMES	11	13	24	681.896
#252	SOX8	11	17	28	918.696
#253	RUNX1	11	20	31	1105.098
#254	ZNF256	11	17	28	2019.575
#255	PKNOX2	11	12	23	227.048
#256	KLF2	11	16	27	668.884
#257	GLI2	11	20	31	767.69
#258	BHLHE41	11	26	37	1394.86
#259	GATA4	11	16	27	716.994
#260	EGR1	11	20	31	1953.442
#261	PPARD	11	16	27	796.412
#262	ZNF169	11	18	29	937.288
#263	RERE	11	12	23	964.042
#264	FOXD2	11	15	26	1037.473
#265	HES1	11	19	30	2091.991
#266	ZNF219	11	15	26	1575.748
#267	SOX17	11	11	22	1298.374
#268	NFE2L3	11	25	36	1570.158
#269	EGR2	11	18	29	1159.693
#270	STAT3	11	11	22	1136.502
#271	HOXD1	11	12	23	760.552
#272	HDX	10	15	25	365.198
#273	RUNX3	10	19	29	3415.793
#274	AR	10	21	31	746.359
#275	TCF7L1	10	11	21	511.129
#276	HOXB4	10	23	33	2001.893
#277	BNC1	10	14	24	431.953
#278	HOXD3	10	11	21	785.813
#279	JDP2	10	16	26	1058.647
#280	ISL2	10	15	25	1977.584
#281	NANOG	10	18	28	636.214
#282	GRHL3	10	15	25	1236.525
#283	C1orf85	10	23	33	2220.722
#284	HOXA11	10	14	24	380.027
#285	GATA5	10	14	24	522.889
#286	GATA2	10	18	28	2477.49
#287	REST	10	14	24	625.217
#288	IRF9	10	11	21	616.97
#289	CREM	10	21	31	1260.882
#290	ZXDA	10	18	28	806.144
#291	ASCL1	10	5	15	148.148
#292	TRIM22	9	15	24	524.542
#293	TFAP2C	9	21	30	846.649
#294	TRPS1	9	25	34	1420.49
#295	ZFHX2	9	19	28	787.638
#296	FOXJ1	9	22	31	817.838
#297	ZKSCAN1	9	17	26	942.122
#298	RARB	9	17	26	763.314
#299	NPAS1	9	21	30	1384.32
#300	GBX2	9	18	27	1483.951
#301	ZNF238	9	24	33	865.301
#302	ZNF93	9	20	29	1360.982
#303	DLX4	9	17	26	1355.838
#304	HOXB13	9	22	31	1909.824
#305	RORC	9	12	21	684.155
#306	MESP1	9	21	30	833.289
#307	TAL1	9	3	12	54.868
#308	PTH	9	10	19	707.44
#309	HSF4	9	23	32	1443.432
#310	PRRX1	9	15	24	631.628
#311	NR4A1	8	21	29	1164.487
#312	PAX6	8	24	32	3258.461
#313	HOXD11	8	12	20	745.702
#314	STAT1	8	16	24	486.525
#315	HAND2	8	18	26	1621.455
#316	KLF7	8	16	24	514.736
#317	HOXD9	8	11	19	481.346
#318	FOXB1	8	4	12	263.207
#319	HOXA2	8	13	21	449.213
#320	HOXC5	8	19	27	2295.714
#321	HIC1	8	13	21	372.329
#322	RUNX1T1	8	22	30	1305.013
#323	FUBP1	8	17	25	1158.714
#324	TRIM29	8	14	22	584.771
#325	OTX1	8	18	26	1727.897
#326	WNT5A	8	18	26	461.335
#327	CREB5	8	16	24	288.68
#328	PROX1	8	12	20	763.302
#329	KLF11	8	15	23	386.835
#330	SP140	8	19	27	1031.383
#331	CDKN2A	8	29	37	2279.072
#332	IRF8	8	13	21	577.559
#333	ZC3H8	7	14	21	909.418
#334	NFIA	7	16	23	944.535
#335	TGIF1	7	13	20	1388.874
#336	GSC	7	25	32	2428.413
#337	NR1D2	7	19	26	518.458
#338	MYCL1	7	18	25	1049.306
#339	E2F5	7	21	28	866.373
#340	ZIC1	7	21	28	615.506
#341	HOXB8	7	10	17	528.79
#342	RORB	7	6	13	132.988
#343	LBX2	7	16	23	690.818
#344	SLC2A4RG	7	20	27	446.17
#345	BATF2	7	15	22	955.132
#346	RXRG	7	8	15	122.484
#347	TP53	7	16	23	1909.625
#348	STAT4	7	16	23	299.872
#349	PITX2	7	21	28	896.551
#350	HES6	7	19	26	891.287
#351	TFCP2	7	13	20	546.301
#352	SOX11	7	16	23	600.907
#353	ERG	7	17	24	538.17
#354	ZNF397	7	17	24	735.587
#355	ZNF33A	7	21	28	1042.162
#356	MLL	7	15	22	665.84
#357	ZNF135	7	12	19	754.137
#358	ZNF643	7	12	19	406.2
#359	GATA1	6	10	16	514.973
#360	MEIS3	6	22	28	593.018
#361	LHX9	6	9	15	979.349
#362	ESRRB	6	9	15	137.668
#363	ZNF268	6	14	20	369.741
#364	POU2F2	6	15	21	1894.039
#365	RHOXF2B	6	7	13	67.644
#366	MYT1L	6	7	13	380.851
#367	ZNF83	6	16	22	387.254
#368	TSHZ2	6	18	24	1044.16
#369	ONECUT1	6	20	26	618.454
#370	POU6F1	6	20	26	872.555
#371	HOXD13	6	18	24	459.003
#372	HNF4G	6	9	15	203.109
#373	ZHX2	6	20	26	602.291
#374	HR	6	22	28	602.485
#375	ZNF323	6	17	23	1226.204
#376	MEOX1	6	11	17	266.918
#377	NR2E1	6	7	13	1015.658
#378	ZNF215	6	18	24	870.856
#379	POU3F1	6	16	22	419.544
#380	SIM2	6	18	24	433.083
#381	SMAD1	6	13	19	923.841
#382	OLIG2	5	18	23	538.799
#383	TAF7	5	15	20	241.655
#384	ZNF132	5	15	20	833.799
#385	ZIC2	5	23	28	591.627
#386	PHTF1	5	17	22	257.206
#387	TSC22D3	5	18	23	272.217
#388	MKX	5	22	27	1532.115
#389	SOX21	5	15	20	517.599
#390	KCNH8	5	13	18	1593.8
#391	C5orf41	5	13	18	357.146
#392	PLAG1	5	21	26	1001.591
#393	MSL3	5	20	25	429.944
#394	SATB2	5	19	24	358.976
#395	SPI1	5	17	22	1413.04
#396	DDIT3	5	21	26	874.718
#397	POU2F3	5	12	17	320.73
#398	HES5	5	9	14	215.946
#399	ZNF140	5	17	22	828.129
#400	TFCP2L1	5	20	25	960.752
#401	TWIST2	5	24	29	1396.281
#402	MXD1	5	15	20	248.335
#403	PRDM2	5	21	26	432.758
#404	MYCN	5	14	19	702.849
#405	HOXC6	5	12	17	741.284
#406	SCML2	5	15	20	483.04
#407	AEBP1	5	21	26	729.291
#408	SALL1	5	20	25	674.674
#409	BTG2	5	18	23	371.145
#410	MYT1	5	18	23	1496.191
#411	HOXA6	4	15	19	444.493
#412	DLX3	4	13	17	1125.973
#413	ISX	4	5	9	120.362
#414	HOXC12	4	18	22	458.526
#415	ELF5	4	8	12	113.282
#416	SOLH	4	19	23	1076.322
#417	NKX3-2	4	25	29	955.404
#418	ETV7	4	18	22	661.49
#419	FOXD4	4	22	26	1042.389
#420	FOXE1	4	17	21	299.135
#421	NKX6-1	4	17	21	766.865
#422	SMAD6	4	16	20	409.978
#423	DLX6	4	20	24	620.895
#424	ZFPM2	4	19	23	334.906
#425	HOPX	4	14	18	343.611
#426	POU4F2	4	9	13	689.574
#427	KDM5B	4	23	27	1165.87
#428	NKX3-1	4	27	31	244.751
#429	BARX1	4	13	17	387.337
#430	ZNF174	4	10	14	75.338
#431	NR1H4	4	10	14	318.81
#432	TFEB	4	22	26	1073.96
#433	ZSCAN12	4	15	19	134.7
#434	SIX2	4	17	21	487.022
#435	PEG3	4	10	14	433.813
#436	EGR4	4	16	20	161.555
#437	ALS2CR8	3	16	19	433.235
#438	FOXF1	3	16	19	506.192
#439	SIX6	3	8	11	104.732
#440	SOX7	3	21	24	1355.904
#441	ZFP37	3	19	22	264.462
#442	WT1	3	26	29	529.377
#443	DMRT2	3	19	22	1492.552
#444	ISL1	3	18	21	143.453
#445	ZNF167	3	24	27	412.104
#446	TGIF2LY	3	8	11	374.418
#447	CSDA	3	15	18	160.439
#448	ESR1	3	7	10	48.549
#449	MEOX2	3	13	16	556.8
#450	ZNF396	3	21	24	717.756
#451	PPARA	3	13	16	183.248
#452	KLF17	3	17	20	379.532
#453	CBL	2	12	14	57.059
#454	FOXP2	2	16	18	747.649
#455	FOXN4	2	16	18	207.585
#456	NKX2-1	2	16	18	245.98
#457	THRB	2	26	28	446.876
#458	NFAT5	2	20	22	662.138
#459	BACH2	2	22	24	869.578
#460	ZIC5	2	25	27	214.005
#461	POU4F1	2	20	22	1007.875
#462	TFAP2B	2	10	12	153.588
#463	HESX1	2	14	16	118.724
#464	ZFP42	2	16	18	295.313
#465	SRF	2	12	14	244.926
#466	HLF	2	24	26	243.96
#467	TBX3	2	21	23	165.265
#468	PGBD1	2	22	24	110.136
#469	HOXC11	2	14	16	84.097
#470	CSRNP3	2	22	24	421.635
#471	ZNF154	2	14	16	1007.029
#472	ESX1	1	12	13	100.883
#473	MTF1	1	16	17	561.145
#474	ST18	1	15	16	226.792
#475	ESR2	1	7	8	9.365
#476	DMRT1	1	15	16	21.63
#477	UHRF1	1	18	19	174.945
#478	TP63	1	23	24	84.879
#479	NEUROG1	1	9	10	18.752
#480	USF1	1	22	23	71.266
#481	ESRRG	1	18	19	635.322
#482	LHX4	1	21	22	381.519
#483	ZSCAN4	1	8	9	1086.861
#484	L3MBTL4	1	14	15	30.911
#485	ATF3	1	16	17	57.153
#486	SHOX	1	11	12	42.766
#487	VENTX	1	14	15	539.422
#488	NR3C2	1	20	21	100.459
#489	VAX2	1	18	19	135.464
#490	IRX2	1	21	22	281.811
#491	RORA	1	23	24	126.726
#492	GSX2	0	6	6	0
#493	TBX19	0	18	18	0
#494	RCOR1	0	10	10	0
#495	ZNF69	0	20	20	0
#496	ATF6	0	9	9	0
#497	TP73	0	15	15	0
#498	ZIC3	0	13	13	0
#499	PPBPL2	0	11	11	0
#500	HOXC4	0	12	12	0