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Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	HOPX	52	1	53	49.847
#2	DLX6	47	5	52	267.881
#3	TFAP2A	47	2	49	188.398
#4	SOX2	44	9	53	323.242
#5	FOXE1	39	5	44	1422.767
#6	CITED2	37	7	44	1512.21
#7	RORC	35	5	40	65.439
#8	TP63	34	9	43	276.906
#9	IRX3	33	8	41	434.281
#10	HR	33	8	41	1700.151
#11	SNAI2	33	9	42	753.5
#12	HOXA7	33	13	46	870.062
#13	GATA4	33	12	45	909.704
#14	HOXC9	32	7	39	1053.74
#15	FOXC2	32	8	40	534.996
#16	ZNF639	32	14	46	1305.011
#17	RAX2	32	9	41	828.765
#18	ZHX2	31	17	48	2117.897
#19	HOXA1	30	13	43	604.709
#20	DMRT2	30	10	40	682.546
#21	NFATC4	30	11	41	1202.654
#22	POU4F2	29	15	44	1241.442
#23	FOXN3	29	11	40	1018.91
#24	NFIX	29	10	39	1122.199
#25	FOSB	29	12	41	483.906
#26	HOXA10	28	10	38	355.206
#27	CREB3L1	28	10	38	517.591
#28	EHF	28	16	44	1591.009
#29	ZNF202	28	10	38	1244.698
#30	HOXD10	28	7	35	405.307
#31	ZNF33A	27	13	40	1106.73
#32	TRIM29	27	7	34	218.587
#33	HOXD11	27	10	37	1427.453
#34	TFCP2L1	27	12	39	878.221
#35	ESR1	26	12	38	652.187
#36	RAX	26	10	36	756.534
#37	TCF3	26	13	39	804.836
#38	E2F4	26	10	36	1382.396
#39	RUNX1	25	13	38	1274.261
#40	ARNTL2	25	10	35	426.683
#41	ZNF256	25	14	39	1245.177
#42	ZFP42	25	13	38	808.051
#43	NR4A3	25	17	42	1005.847
#44	ETV2	25	15	40	1602.016
#45	BNC1	25	13	38	449.81
#46	IRX2	24	19	43	1678.537
#47	NR4A2	24	18	42	869.795
#48	ZNF117	24	15	39	1137.195
#49	SCAND1	24	14	38	974.912
#50	NR2F6	24	15	39	1066.602
#51	IRF7	24	14	38	1556.213
#52	SOX4	24	9	33	905.176
#53	SOX15	24	13	37	597.858
#54	SOX7	24	11	35	1010.524
#55	HOXA9	24	16	40	724.572
#56	ZNF281	23	12	35	996.793
#57	PAX5	23	15	38	882.984
#58	TFEC	23	17	40	1277.833
#59	NKX3-2	23	12	35	1071.133
#60	NFATC1	23	8	31	914.756
#61	TFDP1	23	10	33	799.911
#62	HOXC11	23	9	32	745.427
#63	SOX6	23	15	38	879.033
#64	CREBZF	23	17	40	1416.164
#65	HEY1	23	13	36	459.243
#66	CTBP1	23	20	43	1182.396
#67	SIN3A	22	13	35	818.986
#68	ZSCAN10	22	11	33	826.776
#69	SPEN	22	13	35	913.054
#70	NR1H3	22	16	38	1320.458
#71	STRN3	22	12	34	489.003
#72	ZSCAN1	22	15	37	1423.923
#73	TCF4	22	13	35	671.641
#74	MESP1	22	14	36	848.304
#75	HIC1	22	10	32	510.588
#76	FOXB1	22	21	43	1161.282
#77	TWIST1	22	14	36	904.152
#78	TBX15	22	14	36	988.08
#79	FOXL2	22	17	39	844.02
#80	POU2F3	22	17	39	1207.12
#81	MEF2A	21	12	33	944.856
#82	TEF	21	16	37	917.236
#83	AFF1	21	14	35	898.336
#84	ALS2CR8	21	14	35	1670.989
#85	FOXL1	21	20	41	1172.662
#86	FOXN4	21	14	35	1093.583
#87	TCF20	21	11	32	725.039
#88	PKNOX1	21	12	33	875.606
#89	ZNF367	21	11	32	1659.185
#90	FOXP1	21	11	32	1046.693
#91	TFE3	21	13	34	965.003
#92	ENO1	21	14	35	1181.57
#93	LHX2	21	16	37	1038.119
#94	ZNF165	21	15	36	953.305
#95	ZNF167	21	11	32	828.533
#96	NFATC3	21	17	38	1108.957
#97	MYCN	21	9	30	745.435
#98	ZFP37	21	16	37	948.104
#99	NFKB2	20	20	40	1395.611
#100	HOXB7	20	19	39	1173.198
#101	OTX2	20	12	32	900.158
#102	MYOD1	20	15	35	931.581
#103	SRY	20	10	30	899.113
#104	FOXA3	20	12	32	842.564
#105	MEF2D	20	19	39	1457.526
#106	ZNF483	20	13	33	1018.723
#107	NFE2L2	20	13	33	709.889
#108	ZNF238	20	13	33	1176.578
#109	SIX2	20	14	34	1359.394
#110	FOXK2	20	15	35	1284.091
#111	LEF1	20	22	42	1076.909
#112	GSX1	20	14	34	942.118
#113	ZNF287	20	11	31	739.026
#114	FOXD4	20	16	36	1942.061
#115	NCOR1	20	12	32	796.292
#116	SP1	20	7	27	580.562
#117	RCAN1	20	14	34	723.421
#118	LHX4	19	16	35	966.435
#119	RB1	19	15	34	1352.884
#120	C11orf9	19	11	30	1024.425
#121	REXO4	19	15	34	954.635
#122	SOX11	19	14	33	1009.507
#123	MTF1	19	14	33	1055.715
#124	NR1H4	19	22	41	1471.886
#125	ALX3	19	18	37	1180.529
#126	NFYC	19	12	31	780.677
#127	RARB	19	13	32	1164.013
#128	ISL2	19	10	29	608.433
#129	NFE2L3	19	15	34	974.14
#130	ZNF157	19	16	35	964.397
#131	AFF4	19	12	31	832.835
#132	RELB	19	11	30	655.825
#133	HOXD1	19	11	30	591.476
#134	TGIF1	19	9	28	712.847
#135	WNT5A	19	16	35	737.553
#136	ZNF449	19	15	34	997.019
#137	SIX4	19	9	28	596.392
#138	ARID4A	19	18	37	918.602
#139	PURA	19	12	31	819.73
#140	LASS6	18	11	29	704.588
#141	ZNF3	18	16	34	803.679
#142	GATA3	18	18	36	1107.015
#143	GTF2I	18	16	34	1029.355
#144	FOXM1	18	13	31	617.07
#145	NKX2-1	18	14	32	625.453
#146	ARX	18	14	32	481.206
#147	MEOX1	18	12	30	703.79
#148	FOXD1	18	19	37	495.542
#149	HMGA1	18	13	31	810.773
#150	IRX4	18	15	33	605.692
#151	IRF1	18	16	34	1150.696
#152	TCF21	18	11	29	684.991
#153	ZXDC	18	11	29	609.166
#154	HMG20B	18	21	39	1491.862
#155	SPIC	18	22	40	1718.613
#156	ATF7	18	15	33	749.521
#157	HOXA4	18	14	32	1151.475
#158	ARNT2	18	17	35	1084.825
#159	C12orf28	18	17	35	1258.673
#160	HOXD4	18	12	30	589.004
#161	MBD1	18	17	35	928.71
#162	MSC	18	17	35	1186.064
#163	MEOX2	18	15	33	1000.769
#164	SMAD1	18	17	35	1086.44
#165	NFYB	18	19	37	1356.94
#166	RFX3	18	15	33	1385.429
#167	STAT5B	18	16	34	1113.351
#168	MAFB	18	12	30	535.352
#169	NR2E3	17	11	28	565.075
#170	RXRB	17	19	36	1555.796
#171	ATOH1	17	17	34	629.698
#172	USF1	17	13	30	853.717
#173	CSDA	17	17	34	853.895
#174	ZNF192	17	13	30	721.463
#175	C5orf41	17	17	34	1196.088
#176	SMAD6	17	16	33	1089.336
#177	LASS5	17	17	34	755.99
#178	TBX1	17	17	34	920.641
#179	PAX8	17	18	35	824.349
#180	YBX1	17	17	34	1110.83
#181	FLI1	17	14	31	806.486
#182	ZNF148	17	16	33	955.781
#183	HOXA13	17	10	27	542.483
#184	MYNN	17	17	34	964.641
#185	RXRA	17	18	35	1099.2
#186	VAV1	17	15	32	779.952
#187	TFCP2	17	9	26	836.617
#188	HOXA11	17	11	28	648.02
#189	VTN	17	12	29	710.973
#190	TSC22D1	16	15	31	838.515
#191	GLI2	16	17	33	950.445
#192	ALX1	16	14	30	796.356
#193	DLX2	16	19	35	779.471
#194	TCF7L2	16	15	31	1030.378
#195	ASCL2	16	22	38	1038.801
#196	EGR4	16	12	28	573.11
#197	GLIS3	16	17	33	905.997
#198	ZNF643	16	21	37	1067.332
#199	TAF4B	16	12	28	562.26
#200	HOXD9	16	18	34	1036.962
#201	TSHZ1	16	17	33	978.018
#202	PHTF1	16	14	30	747.071
#203	HMGA2	16	22	38	982.995
#204	PAX4	16	17	33	1199.787
#205	PHOX2A	16	13	29	792.827
#206	ZSCAN4	16	16	32	811.162
#207	NOLC1	16	15	31	1029.746
#208	ZRANB2	16	14	30	856.334
#209	ZNF133	16	12	28	705.313
#210	HES6	16	16	32	821.491
#211	FOXA1	16	14	30	785.824
#212	NR2C1	16	9	25	410.457
#213	TP73	16	18	34	891.273
#214	ZFP36L1	16	18	34	1209.302
#215	ZNF132	16	18	34	1015.136
#216	GRHL3	16	14	30	608.147
#217	NR3C2	16	15	31	842.507
#218	TAF10	16	14	30	1016.625
#219	JUNB	16	19	35	1083.792
#220	HEY2	16	19	35	1157.745
#221	TSC22D4	16	11	27	597.922
#222	KLF9	15	18	33	768.942
#223	GTF2H4	15	21	36	1166.533
#224	ZFHX2	15	12	27	449.586
#225	ZNF91	15	22	37	1325.154
#226	BCL11B	15	11	26	673.397
#227	FOXR2	15	14	29	823.085
#228	ZNF193	15	18	33	758.523
#229	NKX6-1	15	19	34	1070.115
#230	NPAS2	15	15	30	621.192
#231	SLC26A3	15	16	31	793.695
#232	HHEX	15	22	37	1255.268
#233	NEUROD2	15	17	32	845.476
#234	NR4A1	15	9	24	285.77
#235	THRA	15	15	30	606.916
#236	GBX2	15	17	32	898.69
#237	BHLHE41	15	17	32	796.848
#238	KLF17	15	16	31	848.919
#239	ZFHX3	15	15	30	786.004
#240	ATF6	15	14	29	736.895
#241	SNAPC4	15	26	41	1152.51
#242	NFIC	15	16	31	590.301
#243	ZIC3	15	11	26	679.694
#244	TBX10	15	14	29	874.697
#245	KCNH8	15	18	33	736.586
#246	MEF2C	15	14	29	826.875
#247	CREB1	15	17	32	866.489
#248	TBX20	15	20	35	1119.413
#249	VSX1	15	15	30	662.401
#250	MAX	15	16	31	888.063
#251	BHLHE40	15	13	28	1332.835
#252	C2orf3	15	12	27	718.098
#253	ESX1	15	19	34	1445.366
#254	RARG	15	14	29	1172.351
#255	LMO4	15	13	28	978.054
#256	ST18	15	22	37	1009.206
#257	ANKRD30A	15	14	29	915.685
#258	LZTS1	15	15	30	685.766
#259	ETV1	15	17	32	959.31
#260	TSHZ2	15	22	37	1112.049
#261	ZNF215	15	21	36	897.532
#262	EBF1	14	16	30	885.104
#263	EPAS1	14	16	30	720.227
#264	ARNTL	14	19	33	810.152
#265	MLX	14	16	30	907.369
#266	FOXD3	14	17	31	777.078
#267	PAX7	14	17	31	754.611
#268	GATA5	14	17	31	1044.822
#269	ESR2	14	18	32	979.896
#270	SOX5	14	18	32	1151.015
#271	SUPT4H1	14	15	29	705.807
#272	ZNF434	14	19	33	1104.358
#273	NKX2-3	14	14	28	999.997
#274	HCFC1	14	16	30	1026.798
#275	GLI3	14	16	30	771.741
#276	BUD31	14	17	31	1067.104
#277	ETV5	14	12	26	571.499
#278	TULP4	14	28	42	1305.475
#279	SLC2A4RG	14	15	29	850.291
#280	ZFP36L2	14	22	36	1117.487
#281	FOSL2	14	14	28	857.059
#282	TBX22	14	18	32	873.456
#283	MYC	14	17	31	775.375
#284	ZSCAN23	14	17	31	725.998
#285	SUPT6H	14	11	25	367.588
#286	CUX2	14	16	30	789.591
#287	TEAD4	14	14	28	1192.627
#288	SOLH	14	18	32	751.274
#289	DMRT1	14	20	34	867.777
#290	GATAD1	14	18	32	1123.234
#291	MSX1	14	14	28	659.154
#292	KLF4	14	10	24	540.223
#293	RORB	14	14	28	1081.122
#294	PGBD1	14	14	28	994.26
#295	SP140	14	20	34	1062.005
#296	BRD8	14	16	30	871.064
#297	SMAD2	13	17	30	669.642
#298	SPIB	13	12	25	494.844
#299	NR0B1	13	19	32	1184.812
#300	HNF1B	13	16	29	580.862
#301	ZNF277	13	18	31	803.944
#302	ISX	13	14	27	647.17
#303	HSF2	13	20	33	978.813
#304	GABPA	13	11	24	486.752
#305	PLAG1	13	11	24	641.485
#306	MLLT10	13	22	35	1023.463
#307	TSC22D3	13	16	29	748.362
#308	NFIB	13	19	32	944.462
#309	KLF6	13	19	32	820.613
#310	JUND	13	11	24	548.613
#311	ISL1	13	16	29	778.314
#312	SOX21	13	20	33	907.83
#313	MYT1L	13	20	33	970.295
#314	RORA	13	15	28	593.622
#315	ZSCAN20	13	18	31	804.278
#316	FOXA2	13	23	36	671.276
#317	CREB5	13	16	29	763.647
#318	SOX30	13	21	34	912.157
#319	ONECUT3	13	17	30	639.371
#320	MECOM	13	18	31	879.518
#321	GTF2H2	13	21	34	972.841
#322	ZSCAN12	13	16	29	883.052
#323	NR2C2	13	16	29	776.285
#324	ARNT	13	19	32	847.175
#325	ZNF131	13	22	35	1068.221
#326	CSRNP3	13	17	30	797.236
#327	HNRNPAB	13	18	31	734.317
#328	SOX18	13	11	24	462.313
#329	MNX1	13	22	35	1481.915
#330	TWIST2	13	16	29	951.205
#331	ZSCAN21	13	12	25	592.979
#332	BLZF1	13	18	31	868.681
#333	ETV7	13	18	31	965.126
#334	ELK1	13	17	30	779.799
#335	VDR	13	16	29	815.334
#336	SCML1	12	19	31	847.668
#337	PAX6	12	23	35	610.625
#338	LHX8	12	18	30	646.917
#339	MGA	12	15	27	605.49
#340	MKX	12	21	33	1105.057
#341	FOXP2	12	17	29	735.684
#342	IRX1	12	18	30	929.278
#343	ONECUT2	12	17	29	798.042
#344	TBX5	12	21	33	1202.623
#345	HLF	12	17	29	902.879
#346	EDF1	12	21	33	952.173
#347	SMAD4	12	18	30	881.573
#348	HOXA2	12	11	23	575.677
#349	T	12	21	33	920.075
#350	POU3F2	12	22	34	950.54
#351	DLX4	12	13	25	502.783
#352	ZKSCAN1	12	18	30	791.773
#353	HOXB2	12	18	30	836.811
#354	ZEB2	12	13	25	547.63
#355	NANOG	12	15	27	862.206
#356	PBX1	12	18	30	791.259
#357	NEUROD1	12	16	28	544.404
#358	SNAI3	12	19	31	891.218
#359	PRDM2	12	16	28	751.768
#360	POU2F1	12	17	29	741.296
#361	IKZF3	12	17	29	678.449
#362	KLF2	12	9	21	689.35
#363	THRB	12	14	26	827.474
#364	MLXIPL	12	12	24	638.924
#365	CREB3L3	12	11	23	530.23
#366	NR5A1	12	22	34	912.88
#367	ZNF323	12	21	33	896.372
#368	L3MBTL4	12	13	25	834.321
#369	ZKSCAN3	11	19	30	588.287
#370	ZNF135	11	15	26	770.825
#371	ATF2	11	17	28	720.816
#372	PGR	11	13	24	566.423
#373	ZNF41	11	19	30	755.362
#374	MSX2	11	14	25	741.059
#375	ESRRG	11	19	30	719.2
#376	PCGF2	11	16	27	698.835
#377	SPDEF	11	17	28	632.04
#378	SNAPC5	11	20	31	766.01
#379	HOXD3	11	16	27	460.788
#380	HOXB8	11	22	33	919.49
#381	ZNF93	11	24	35	1060.548
#382	RARA	11	18	29	723.716
#383	OLIG2	11	15	26	685.091
#384	HSF1	11	15	26	667.721
#385	MIXL1	11	21	32	820.069
#386	NOBOX	11	17	28	727.752
#387	SCRT1	11	12	23	584.295
#388	ZNF175	11	21	32	845.641
#389	POU4F1	11	21	32	831.149
#390	FOXO3	11	16	27	808.919
#391	ALX4	11	15	26	535.938
#392	FOXG1	11	16	27	640.281
#393	HDX	11	15	26	662.693
#394	WT1	11	15	26	617.488
#395	HNF4G	11	17	28	590.759
#396	NFYA	11	16	27	566.434
#397	TFDP2	11	13	24	456.159
#398	ASCL1	10	22	32	973.741
#399	E2F2	10	17	27	600.719
#400	ZNF496	10	20	30	516.279
#401	NR2F2	10	18	28	818.119
#402	TBX2	10	19	29	592.629
#403	TBR1	10	22	32	724.286
#404	BARX1	10	20	30	710.91
#405	SCAND2	10	16	26	646.198
#406	NFIA	10	19	29	770.059
#407	TRIM28	10	16	26	607.49
#408	ZFHX4	10	16	26	536.777
#409	ZNF397	10	17	27	622.6
#410	PPARA	10	21	31	904.183
#411	MITF	10	22	32	772.406
#412	ZNF75D	10	20	30	592.249
#413	ZNF207	10	14	24	620.767
#414	NR5A2	10	20	30	567.395
#415	SALL1	10	17	27	1092.756
#416	ZNF92	10	23	33	863.976
#417	LHX1	10	19	29	671.055
#418	BACH1	10	18	28	726.094
#419	TP53	10	13	23	439.633
#420	MAF	10	20	30	682.553
#421	NEUROG1	10	15	25	548.049
#422	DMBX1	10	22	32	898.553
#423	TSC22D2	10	17	27	426.289
#424	NFX1	10	20	30	779.392
#425	BCL3	10	15	25	675.868
#426	ATF6B	10	16	26	487.169
#427	CREM	10	15	25	657.535
#428	ZNF90	10	23	33	1071.671
#429	TADA3	9	13	22	570.185
#430	CBFA2T2	9	16	25	415.471
#431	IRF6	9	16	25	542.995
#432	ZNF19	9	16	25	486.758
#433	SOX13	9	15	24	576.843
#434	CEBPD	9	22	31	718.531
#435	ZNF396	9	19	28	653.432
#436	PTH	9	17	26	664.352
#437	SIM2	9	20	29	804.857
#438	HSF5	9	18	27	665.593
#439	ZNF81	9	15	24	584.663
#440	RUNX1T1	9	16	25	516.296
#441	HIRA	9	16	25	463.041
#442	ELF1	9	20	29	647.55
#443	NR1I2	9	15	24	526.766
#444	IRX5	9	22	31	726.972
#445	REL	9	17	26	499.031
#446	ZHX1	9	16	25	577.675
#447	SIM1	9	17	26	455.035
#448	ZNF45	9	16	25	444.205
#449	CDKN2A	9	21	30	636.023
#450	SIX3	9	23	32	821.219
#451	HOXB9	8	20	28	594.392
#452	PROX1	8	20	28	579.878
#453	SMAD3	8	21	29	646.9
#454	HIF3A	8	18	26	572.226
#455	LHX9	8	23	31	701.491
#456	POU1F1	8	19	27	506.801
#457	MLL	8	23	31	847.3
#458	SP3	8	20	28	558.087
#459	TFAP2B	8	22	30	871.192
#460	ERG	8	17	25	519.71
#461	NPAT	8	17	25	583.802
#462	SATB2	8	18	26	835.102
#463	TEAD2	8	17	25	856.043
#464	FOXP3	7	18	25	674.296
#465	ZNF268	7	13	20	400.538
#466	FOXO1	7	18	25	333.102
#467	HOXD13	7	20	27	444.581
#468	IKZF1	7	17	24	507.64
#469	ZIC1	7	25	32	526.662
#470	ZNF197	7	17	24	494.718
#471	ZNF500	7	13	20	376.734
#472	ZNF169	7	11	18	198.922
#473	TAF12	7	16	23	469.003
#474	GAS7	7	20	27	630.319
#475	LMX1A	7	21	28	679.924
#476	ZNF83	7	17	24	377.65
#477	ZEB1	7	18	25	445.274
#478	PLSCR1	7	28	35	711.747
#479	PPARD	7	18	25	636.317
#480	TBX3	7	17	24	419.654
#481	ZNF33B	7	15	22	375.232
#482	TEAD1	7	22	29	788.255
#483	ZIC2	7	22	29	524.731
#484	SCAND3	7	18	25	610.251
#485	NR1I3	6	17	23	293.797
#486	RUNX2	6	23	29	559.453
#487	SOX1	6	21	27	577.622
#488	DLX1	6	25	31	514.487
#489	ESRRB	6	20	26	505.74
#490	FOS	6	19	25	377.57
#491	TCF12	6	16	22	362.197
#492	AHCTF1	6	26	32	757.994
#493	C1orf85	6	18	24	417.3
#494	ZNF154	6	16	22	358.692
#495	NRL	5	17	22	326.083
#496	TAL1	5	18	23	288.006
#497	KLF12	4	21	25	274.165
#498	TAF13	4	23	27	273.014
#499	PAX3	3	18	21	286.113
#500	GSC2	3	17	20	241.245