Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	E2F4	105	0	105	0
#2	ELK1	95	8	103	64.452
#3	PKNOX2	88	10	98	3558.475
#4	HOXC11	87	4	91	61.947
#5	TFAP4	86	7	93	2021.934
#6	ZNF236	85	1	86	0.486
#7	PPARD	81	8	89	68.712
#8	CBL	80	4	84	25.892
#9	FOSL1	78	5	83	23.736
#10	HOXD9	77	5	82	1992.883
#11	USF2	77	12	89	1430.63
#12	SCAND2	76	7	83	48.381
#13	REST	76	8	84	348.599
#14	IKZF1	74	9	83	158.863
#15	HEY1	71	18	89	8631.419
#16	TBX5	71	13	84	1748.373
#17	T	70	8	78	80.1
#18	ZNF444	69	11	80	49.978
#19	GABPB1	64	16	80	369.65
#20	ATF7	64	14	78	3667.814
#21	ESRRG	63	15	78	2540.194
#22	SPDEF	62	4	66	233.532
#23	TCEAL1	61	10	71	241.517
#24	ZNF3	61	17	78	13082.2
#25	MLXIPL	61	13	74	481.106
#26	FOXJ3	61	12	73	502.754
#27	TBX19	60	17	77	215.083
#28	PAX3	58	11	69	11546.604
#29	HNF1B	57	14	71	127.584
#30	ZSCAN18	57	14	71	286.975
#31	ZNF287	56	5	61	1479.351
#32	HMG20A	55	9	64	1113.596
#33	CREB3L1	55	14	69	243.807
#34	VDR	55	8	63	920.077
#35	E2F3	54	7	61	159.626
#36	FOXN3	54	17	71	133.161
#37	ZFHX3	54	8	62	455.291
#38	RUNX2	53	5	58	81.205
#39	MLX	53	16	69	442.498
#40	LZTR1	53	20	73	364.569
#41	NFE2L2	53	14	67	391.095
#42	TCF3	53	8	61	299.316
#43	LHX3	52	14	66	1469.131
#44	PAX8	52	14	66	190.988
#45	TRIM29	52	12	64	254.039
#46	ATF6B	50	19	69	1516.477
#47	FOXA2	50	6	56	28.294
#48	ZNF446	49	19	68	9472.92
#49	RFX5	48	16	64	140.831
#50	HNF4A	48	16	64	1187.267
#51	SNAPC4	48	18	66	523.461
#52	HMX1	48	9	57	652.561
#53	AFF4	48	24	72	795.164
#54	CNBP	48	16	64	1429.529
#55	KDM5A	48	8	56	924.674
#56	TARDBP	47	30	77	2031.332
#57	CTCF	47	28	75	540.778
#58	GTF2H4	46	10	56	177.385
#59	SOX13	46	18	64	6640.142
#60	TFCP2L1	46	15	61	106.802
#61	EMX1	45	6	51	496.027
#62	HOXB13	45	5	50	35.674
#63	TRIM28	45	22	67	25471.034
#64	RERE	45	20	65	64170.215
#65	AR	44	11	55	2453.605
#66	SIX1	44	9	53	651.075
#67	GLI3	44	24	68	770.811
#68	NOTCH1	43	14	57	1743.177
#69	MTF1	43	13	56	372.342
#70	HOXC13	43	12	55	136.937
#71	FOXG1	43	5	48	136.684
#72	HIF3A	43	16	59	231.152
#73	SP3	43	24	67	1000.819
#74	SOX2	41	17	58	491.882
#75	ZNF131	41	25	66	8873.085
#76	ATF2	41	28	69	4069.378
#77	RARG	41	23	64	955.248
#78	BRD8	40	22	62	478.596
#79	SOX10	40	19	59	846.99
#80	ZHX3	40	17	57	1435.509
#81	TAF4B	39	18	57	667.227
#82	TFAP2B	39	9	48	323.095
#83	NR1I2	39	21	60	5940.932
#84	ZNF24	39	13	52	3008.867
#85	ZNF175	39	11	50	199.016
#86	CREB3	39	14	53	2527.983
#87	TULP4	39	19	58	1705.882
#88	PRRX2	39	26	65	7712.494
#89	ZNF33B	39	5	44	3680.469
#90	TCF4	39	27	66	2496.194
#91	MYT1	38	13	51	1182.543
#92	ZNF434	38	26	64	1478.119
#93	NFIC	38	17	55	2616.543
#94	ZNF83	38	19	57	675.435
#95	RARB	38	26	64	1933.765
#96	PRDM1	38	14	52	764.327
#97	AFF1	38	27	65	1377.559
#98	POU6F1	37	5	42	75.177
#99	TEAD4	37	10	47	66.656
#100	TGIF1	37	16	53	1743.281
#101	DBP	37	3	40	4.763
#102	ZNF394	37	16	53	971.073
#103	NR2F6	36	34	70	1233.59
#104	PHTF1	36	14	50	501.392
#105	MYOG	36	9	45	428.122
#106	HDAC1	36	22	58	1450.169
#107	HMGA1	36	17	53	2033.963
#108	FOXO1	36	26	62	2453.65
#109	LMX1B	35	6	41	22.912
#110	FUBP1	35	19	54	3223.666
#111	HNRNPAB	35	15	50	1553.608
#112	NR3C1	35	26	61	6644.931
#113	REL	35	21	56	691.216
#114	HOXC8	35	12	47	6524.769
#115	BTAF1	35	12	47	1446.818
#116	TAF5L	34	17	51	10926.096
#117	IRF3	34	29	63	671.862
#118	TCF15	33	14	47	1463.725
#119	NR4A3	33	18	51	252.786
#120	GATA6	33	1	34	599.357
#121	MZF1	33	25	58	1905.431
#122	CBFB	33	33	66	9244.9
#123	SRY	33	19	52	1710.604
#124	POU5F1B	33	19	52	1228.242
#125	HDAC2	33	19	52	490.558
#126	CITED2	33	8	41	27967.864
#127	NR2C1	33	7	40	533.222
#128	ZKSCAN1	33	13	46	461.816
#129	NFIL3	32	4	36	590.346
#130	CNOT7	32	29	61	960.72
#131	TCF7L1	32	22	54	9791.891
#132	CREBL2	32	13	45	1944.215
#133	PBX3	32	14	46	896.643
#134	FOXJ1	32	8	40	2040.234
#135	ESR2	32	28	60	1007.599
#136	ESR1	32	23	55	1362.009
#137	ELK4	32	19	51	12799.583
#138	TCF12	32	25	57	1361.337
#139	ZNF215	31	22	53	221.988
#140	RUNX1T1	31	16	47	386.249
#141	BUD31	31	28	59	969.442
#142	HOXA2	31	21	52	13805.654
#143	ZEB1	31	22	53	699.747
#144	E4F1	31	24	55	1377.961
#145	ZNF207	30	32	62	2904.487
#146	NR1H3	30	26	56	37791.164
#147	TSC22D4	30	17	47	776.284
#148	HCFC1	30	23	53	1263.371
#149	MAFG	30	26	56	7013.878
#150	ECSIT	30	30	60	1159.578
#151	NR4A2	30	5	35	273.07
#152	TFE3	30	23	53	1256.607
#153	CEBPB	30	18	48	3524.836
#154	HMGB2	30	29	59	555.313
#155	PURA	30	27	57	1071.304
#156	HAND2	29	22	51	965.183
#157	KLF12	29	18	47	54790.276
#158	PHOX2B	29	20	49	474.701
#159	ATF3	29	5	34	644.62
#160	E2F1	29	23	52	963.913
#161	CREB3L2	29	30	59	4574.755
#162	ZNF148	29	25	54	6063.136
#163	MYT1L	29	12	41	205.94
#164	ZNF197	29	17	46	395.528
#165	ZNF187	29	21	50	210.873
#166	RORA	29	23	52	2810.023
#167	TBX3	29	11	40	773.202
#168	PBX2	28	37	65	8181.073
#169	IRF2	28	25	53	2993.721
#170	ZNF75D	28	18	46	1905.818
#171	TCF25	28	22	50	3247.39
#172	HEYL	28	21	49	1023.321
#173	YBX1	28	22	50	1079.307
#174	NOLC1	28	34	62	1811.587
#175	NR5A1	28	26	54	825.509
#176	NR6A1	28	31	59	1592.005
#177	PFDN1	27	26	53	3836.147
#178	SALL2	27	31	58	629.546
#179	MYNN	27	22	49	175.35
#180	BHLHE41	27	33	60	1282.091
#181	MAFB	27	16	43	791.525
#182	PHF1	27	38	65	1710.739
#183	TAL1	27	11	38	216.126
#184	TP63	27	23	50	247.668
#185	MBD1	27	27	54	1410.763
#186	MSRB2	27	37	64	2279.981
#187	FOXO4	26	11	37	2072.401
#188	SOX12	26	21	47	473.544
#189	PA2G4	26	33	59	2143.67
#190	TEF	26	26	52	405.953
#191	HES1	26	16	42	731.192
#192	KLF6	26	15	41	1425.976
#193	MSL3	26	26	52	788.235
#194	HOXA11	26	24	50	10812.115
#195	ADNP2	25	29	54	3291.476
#196	NKX3-1	25	6	31	23.853
#197	NKX2-8	25	15	40	3466.526
#198	EGR4	25	14	39	10620.677
#199	TBR1	25	25	50	11101.718
#200	RUNX1	25	23	48	374.183
#201	PCGF2	25	20	45	903.269
#202	RORC	25	25	50	3087.787
#203	MTA1	25	32	57	1209.8
#204	HIC1	25	9	34	217.481
#205	ZSCAN5A	24	20	44	859.79
#206	LHX6	24	22	46	125.449
#207	TFAP2A	24	17	41	544.393
#208	TSC22D2	24	30	54	21705.481
#209	TFEC	24	27	51	216.447
#210	CNOT8	24	18	42	617.677
#211	BATF3	24	28	52	447.201
#212	PKNOX1	24	22	46	1068.317
#213	EGR3	24	11	35	13461.668
#214	THRA	24	26	50	379.088
#215	SOX15	24	8	32	71.32
#216	CBFA2T2	23	19	42	453.877
#217	ZNF93	23	29	52	281.057
#218	YY1	23	22	45	343.155
#219	SCAND1	23	35	58	2496.938
#220	MAF	23	19	42	616.188
#221	UBP1	23	28	51	1061.457
#222	RARA	23	29	52	2079.893
#223	RXRB	23	39	62	1372.216
#224	TADA2A	23	28	51	537.706
#225	HOXA10	23	28	51	2104.088
#226	PRDM2	23	31	54	265.946
#227	ATF1	23	25	48	855.754
#228	ZNF263	23	15	38	136.593
#229	TBX4	22	18	40	374.409
#230	POU3F3	22	16	38	365.625
#231	DRAP1	22	40	62	1177.591
#232	FOXJ2	22	33	55	1260.153
#233	DMTF1	22	8	30	142.71
#234	NR1H4	22	27	49	9394.582
#235	EDF1	22	30	52	2341.033
#236	ARNT	22	24	46	280.622
#237	RXRA	22	28	50	2174.757
#238	HOXD11	22	29	51	2701.761
#239	IRX5	22	31	53	37013.51
#240	OVOL1	22	14	36	276.096
#241	SLC26A3	21	21	42	388.576
#242	ONECUT2	21	8	29	378.223
#243	ADNP	21	22	43	1128.994
#244	HOXD1	21	24	45	646.709
#245	NFYA	21	13	34	513.924
#246	NR4A1	21	7	28	381.87
#247	HOXD4	21	15	36	195.621
#248	ZNF134	21	17	38	891.126
#249	MYOD1	21	23	44	832.146
#250	FBXW7	21	25	46	387.81
#251	MAX	21	35	56	437.748
#252	ELF1	20	17	37	883.637
#253	CSDA	20	31	51	1479.341
#254	HOXA5	20	10	30	333.799
#255	CTBP1	20	43	63	1998.992
#256	MLL	20	46	66	1625.627
#257	STAT3	20	16	36	629.89
#258	TAF7	20	30	50	546.487
#259	CLOCK	20	28	48	835.051
#260	ALX1	20	13	33	198.277
#261	ST18	20	29	49	3485.743
#262	EVX1	20	26	46	350.849
#263	ETV4	20	24	44	187.137
#264	VTN	20	29	49	1529.731
#265	MEF2A	20	33	53	2295.176
#266	MYBL2	20	33	53	1151.1
#267	FOXN2	20	24	44	2510.467
#268	CEBPA	20	16	36	412.832
#269	SP4	20	27	47	1919.375
#270	HOXB9	20	33	53	759.163
#271	GBX1	20	16	36	1520.153
#272	EGR2	20	3	23	58.48
#273	ZBTB25	20	29	49	1055.009
#274	PAX6	20	26	46	388.723
#275	ERG	20	28	48	1089.287
#276	GATAD1	19	37	56	1751.236
#277	ZNF133	19	31	50	318.272
#278	RNF4	19	31	50	1549.14
#279	SMAD5	19	31	50	602.49
#280	CSRNP3	19	39	58	806.344
#281	PLAGL2	19	12	31	38.396
#282	GCFC1	19	21	40	543.923
#283	HIF1A	19	39	58	1431.941
#284	NFAT5	19	22	41	1414.063
#285	CREB1	19	11	30	30.233
#286	TFEB	19	23	42	398.319
#287	NFKB2	19	22	41	2719.321
#288	CEBPD	19	17	36	354.682
#289	FOXK2	19	9	28	887.6
#290	CTNNB1	19	27	46	440.623
#291	NFATC4	19	38	57	1081.068
#292	JUN	19	16	35	985.513
#293	CCRN4L	19	34	53	189.619
#294	HOXB2	19	48	67	2854.002
#295	TSC22D1	18	23	41	301.197
#296	SMAD6	18	9	27	1284.278
#297	FOXN1	18	23	41	375.276
#298	FOS	18	21	39	5886.308
#299	MYC	18	15	33	3478.461
#300	SNAPC2	18	15	33	422.975
#301	FOSL2	18	13	31	182.459
#302	SNAPC5	18	33	51	604.16
#303	NR2F2	18	18	36	527.475
#304	MGA	18	26	44	1609.234
#305	SNAI2	18	26	44	356.238
#306	RELA	18	35	53	3464.335
#307	TRIM25	18	27	45	285.228
#308	HNRNPK	18	42	60	1208.963
#309	SATB1	17	29	46	1806.913
#310	SLC2A4RG	17	36	53	675.25
#311	NFATC3	17	8	25	22.472
#312	TWIST1	17	29	46	1166.883
#313	NR2F1	17	38	55	1186.618
#314	ZNF274	17	33	50	4865.79
#315	IRX4	17	24	41	660.51
#316	ETV6	17	24	41	1061.033
#317	IRF4	17	23	40	228.384
#318	HOXB1	17	24	41	972.574
#319	STAT2	17	22	39	803.988
#320	GATA3	16	27	43	1243.785
#321	MSX2	16	18	34	269.805
#322	PLAG1	16	22	38	1281.348
#323	TFDP1	16	36	52	1195.783
#324	TLX2	16	30	46	1275.064
#325	LZTS1	16	26	42	1008.427
#326	FOXC1	16	29	45	977.892
#327	GTF2IRD1	16	37	53	8815.665
#328	ERF	16	13	29	232.495
#329	BCL6	16	27	43	543.766
#330	FOXO3	16	34	50	470.033
#331	ELK3	15	19	34	502.802
#332	KLF5	15	19	34	712.529
#333	CREM	15	19	34	2277.64
#334	NR0B1	15	26	41	10305.034
#335	NFATC1	15	24	39	1007.529
#336	MLLT10	15	12	27	39.49
#337	HIRA	15	31	46	2264.933
#338	KLF2	15	19	34	4592.018
#339	MYCL1	15	29	44	129.779
#340	PHOX2A	15	28	43	1167.081
#341	ZNF219	15	27	42	1549.501
#342	SMAD1	15	34	49	363.141
#343	ELF3	15	32	47	2001.054
#344	HSF1	14	36	50	661.101
#345	STAT4	14	35	49	531.766
#346	MAFF	14	23	37	222.055
#347	HR	14	27	41	1232.155
#348	NFIB	14	16	30	1711.558
#349	MEIS1	14	33	47	3206.182
#350	ETS2	14	30	44	787.14
#351	FOXM1	14	33	47	268.794
#352	XBP1	14	33	47	1480.483
#353	VAV1	14	22	36	406.586
#354	HOXD3	14	27	41	398.688
#355	SMAD2	14	20	34	274.526
#356	KLF10	13	28	41	3049.964
#357	ARNT2	13	40	53	6259.44
#358	ZFHX4	13	32	45	5399.041
#359	FOSB	13	12	25	403.623
#360	UBN1	13	31	44	519.232
#361	ZNF238	13	35	48	1222.928
#362	ZNF91	13	27	40	2722
#363	ZFP37	13	29	42	718.185
#364	TADA3	13	33	46	674.99
#365	HOXC5	13	21	34	159.589
#366	TAF6	13	41	54	418.99
#367	SLC30A9	13	41	54	449.028
#368	E2F6	13	28	41	169.641
#369	NPAT	13	45	58	398.396
#370	RBCK1	13	28	41	1175.308
#371	CREB5	13	21	34	467.132
#372	FEV	13	29	42	1206.375
#373	NR3C2	13	40	53	1368.414
#374	EGR1	13	9	22	72.928
#375	NFKB1	13	38	51	2886.284
#376	GATA2	12	26	38	742.887
#377	SIX2	12	30	42	1461.637
#378	SPEN	12	38	50	401.721
#379	POU2F2	12	25	37	370.785
#380	PBX1	12	38	50	10645.668
#381	LASS6	11	29	40	333.622
#382	KDM5B	11	26	37	747.05
#383	REXO4	11	32	43	354.306
#384	ATF5	11	36	47	1312.987
#385	MEF2C	11	38	49	900.207
#386	POU2F1	11	41	52	634.578
#387	IRF7	11	30	41	220.174
#388	NEUROD1	11	22	33	58.557
#389	TGIF2	11	36	47	377.44
#390	STAT1	11	23	34	429.549
#391	SRF	11	35	46	581.862
#392	LMO4	11	41	52	1929.696
#393	TAF10	11	37	48	569.132
#394	TBX1	10	23	33	231.242
#395	KLF7	10	37	47	290.457
#396	HOXB7	10	27	37	436.098
#397	ZNF174	10	25	35	524.492
#398	KLF9	10	33	43	222.513
#399	STAT5A	10	41	51	3181.722
#400	AEBP1	10	29	39	209.847
#401	GAS7	10	35	45	247.646
#402	CDX2	10	13	23	102.716
#403	ZGPAT	10	37	47	450.657
#404	SUPT4H1	9	34	43	870.758
#405	PLSCR1	9	19	28	93.774
#406	HNF4G	9	14	23	79.987
#407	IRF1	9	32	41	908.358
#408	NPAS2	9	32	41	2336.079
#409	CREBBP	9	33	42	337.844
#410	ZNF189	9	38	47	1129.46
#411	BHLHE40	9	28	37	141.35
#412	JUND	9	48	57	1161.298
#413	SMAD3	9	35	44	240.325
#414	PEG3	9	37	46	3474.791
#415	IRF9	8	27	35	1019.294
#416	ELF2	8	41	49	1405.913
#417	FOXP3	8	30	38	698.237
#418	MMP14	8	34	42	316.464
#419	TBX2	8	39	47	218.639
#420	MNT	8	42	50	1905.221
#421	SOX11	8	37	45	1588.182
#422	SOLH	8	37	45	406.237
#423	EPAS1	8	28	36	935.898
#424	RCAN1	8	43	51	747.528
#425	VAX2	8	29	37	291.235
#426	PAX5	8	38	46	2448.158
#427	HOXB3	8	34	42	435.137
#428	LEF1	8	26	34	196.261
#429	NCOR1	8	26	34	438.322
#430	AATF	8	42	50	2484.531
#431	TRIM22	7	21	28	578.185
#432	HCLS1	7	32	39	429.684
#433	ATF6	7	53	60	909.24
#434	TFCP2	7	42	49	283.915
#435	DLX2	7	43	50	523.356
#436	SREBF2	7	41	48	314.168
#437	TSHZ2	7	33	40	106.305
#438	AHR	7	40	47	1168.235
#439	LASS2	7	40	47	1271.276
#440	SOX9	7	36	43	490.749
#441	PTTG1	7	52	59	286.754
#442	ENO1	7	39	46	1126.639
#443	ZBTB38	7	32	39	851.576
#444	TCF7L2	7	34	41	489.926
#445	FOXL1	7	31	38	163.997
#446	ZFP36L2	6	16	22	561.509
#447	BCL3	6	41	47	721.817
#448	KLF4	6	27	33	183.221
#449	BTG2	6	18	24	69.844
#450	TCF20	6	43	49	217.697
#451	HOXB6	6	40	46	105.819
#452	SCMH1	6	52	58	740.343
#453	ZNF85	6	37	43	189.231
#454	ZNF268	6	53	59	861.924
#455	TP53	6	25	31	1539.734
#456	NFE2L1	6	48	54	648.33
#457	HOXB5	6	35	41	1217.353
#458	SCML2	6	44	50	493.123
#459	HOXA9	5	39	44	1915.491
#460	CUX1	5	30	35	197.902
#461	ZHX2	5	35	40	3143.142
#462	ETV1	5	43	48	111.89
#463	MEIS2	5	47	52	1002.879
#464	MEIS3P1	5	37	42	1333.46
#465	CDKN2A	5	35	40	1069.439
#466	ETV5	5	39	44	205.461
#467	ISL1	5	37	42	2706.889
#468	HSF4	5	27	32	388.306
#469	CIR1	4	33	37	877.886
#470	STAT5B	4	42	46	1019.442
#471	STAT6	4	50	54	277.133
#472	TSC22D3	4	36	40	1670.338
#473	HMBOX1	4	47	51	204.279
#474	JUNB	4	26	30	310.965
#475	HLF	4	43	47	111.334
#476	DDIT3	4	46	50	205.125
#477	SUPT6H	4	39	43	392.265
#478	CITED1	4	39	43	431.001
#479	CSRNP2	4	41	45	238.74
#480	TCF7	3	36	39	93.66
#481	SREBF1	3	34	37	1032.935
#482	MYCN	3	43	46	1158.184
#483	SOX4	3	49	52	82.006
#484	ATF4	3	31	34	105.419
#485	SIX3	3	46	49	316.888
#486	HOXC4	3	44	47	496.78
#487	TFAP2C	3	34	37	86.308
#488	RBPJ	2	46	48	46.81
#489	ASCL1	2	51	53	568.612
#490	ARNTL	2	41	43	737.56
#491	GATAD2A	2	44	46	154.621
#492	HOXA7	2	44	46	51.078
#493	BATF	2	30	32	104.865
#494	MSX1	2	46	48	90.708
#495	CREBZF	2	36	38	411.855
#496	HOXC10	1	51	52	28.582
#497	IRF6	1	41	42	150.145
#498	NRL	1	37	38	35.283
#499	HAND1	0	49	49	0
#500	HMGB1	0	46	46	0