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Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	DMTF1	88	6	94	2978.031
#2	ELK3	85	5	90	1848.921
#3	NFYC	82	6	88	1229.507
#4	E2F3	78	5	83	1287.66
#5	NPAT	76	5	81	332.005
#6	GATA3	73	7	80	1083.642
#7	CSDA	71	10	81	388.306
#8	HCLS1	69	2	71	158.237
#9	FOXA1	67	1	68	21.143
#10	E2F6	64	10	74	675.919
#11	TRIM22	62	3	65	374.14
#12	ATF1	61	7	68	529.631
#13	IRF2	61	6	67	2365.641
#14	NFE2	60	7	67	573.779
#15	TADA3	60	13	73	1729.777
#16	JUND	60	10	70	1264.303
#17	ATF6	59	11	70	2089.461
#18	XBP1	58	3	61	840.207
#19	CDKN2A	56	4	60	813.437
#20	HAND1	56	6	62	439.155
#21	MAFB	55	3	58	55.103
#22	EPAS1	54	8	62	1655.551
#23	SRF	54	17	71	2213.312
#24	TCF4	54	3	57	39.704
#25	AEBP1	54	3	57	392.166
#26	PLSCR1	53	7	60	501.042
#27	HIF1A	52	10	62	746.11
#28	KLF11	50	15	65	891.215
#29	SPDEF	50	7	57	152.801
#30	FOXM1	50	5	55	3081.907
#31	SNAI2	49	6	55	122.063
#32	ADNP2	49	11	60	1115.141
#33	ZNF83	49	5	54	122.695
#34	NR3C1	49	12	61	1124.148
#35	ATF2	49	11	60	1259.942
#36	BCL3	49	11	60	1115.884
#37	AR	48	9	57	121.027
#38	SREBF1	48	3	51	37.826
#39	TAL1	48	4	52	257.709
#40	PHOX2B	47	10	57	1205.572
#41	FOXC1	47	3	50	123.898
#42	ESR1	47	8	55	151.618
#43	HDAC2	46	5	51	120.968
#44	TCF3	46	15	61	1454.845
#45	CTBP1	45	9	54	917.205
#46	ECSIT	44	13	57	787.283
#47	MAX	44	4	48	73.254
#48	E4F1	44	11	55	745.202
#49	TSHZ2	44	17	61	1869.709
#50	BHLHE40	43	11	54	607.512
#51	KLF1	43	10	53	1010.94
#52	ZNF217	42	11	53	751.44
#53	FOXO1	42	14	56	1453.68
#54	GAS7	42	8	50	497.952
#55	NFE2L1	41	11	52	733.01
#56	IRX5	41	11	52	2593.827
#57	EN1	41	7	48	237.915
#58	TBR1	41	22	63	3301.6
#59	REXO4	41	17	58	1455.842
#60	NFYA	41	15	56	561.747
#61	ZNF219	41	17	58	613.032
#62	NOTCH1	40	14	54	2018.968
#63	KLF9	40	19	59	4461.677
#64	SUPT6H	40	13	53	556.312
#65	TFCP2	40	18	58	782.026
#66	BHLHE41	39	17	56	1309.276
#67	HSF1	39	15	54	884.474
#68	MAFF	39	16	55	461.695
#69	MEOX1	39	14	53	442.501
#70	NR4A3	38	24	62	3189.734
#71	ZEB2	38	12	50	1893.549
#72	CNOT8	38	18	56	1562.41
#73	ENO1	38	5	43	104.299
#74	HOXA5	37	18	55	1543.852
#75	ZNF277	37	13	50	648.73
#76	HMGB2	36	12	48	442.595
#77	NFYB	35	15	50	709.98
#78	LHX6	35	19	54	1060.927
#79	ARNT2	35	24	59	1073.535
#80	ZNF165	35	18	53	3618.151
#81	GABPA	34	15	49	948.44
#82	RUNX1	34	21	55	2403.093
#83	ZFPM2	34	14	48	639.542
#84	ELF1	34	19	53	1189.391
#85	SOX11	33	16	49	364.258
#86	SOX10	33	9	42	441.957
#87	RELB	33	19	52	1058.84
#88	PBX2	33	17	50	1249.48
#89	GLI2	33	18	51	1853.478
#90	TAF12	33	5	38	994.14
#91	MGA	32	17	49	911.903
#92	HIRA	32	16	48	990.171
#93	ESRRA	32	19	51	629.757
#94	STAT3	32	20	52	949.013
#95	PBX1	31	17	48	487.928
#96	SOX4	31	16	47	975.241
#97	MEF2D	31	23	54	2175.971
#98	ISL1	31	24	55	1555.555
#99	AHR	31	14	45	472.234
#100	MYC	31	16	47	1391.745
#101	NFATC4	31	12	43	330.662
#102	OVOL1	31	21	52	602.487
#103	ZNF91	30	14	44	472.699
#104	CBFB	30	15	45	639.836
#105	SPIB	30	16	46	746.19
#106	GTF2H3	30	21	51	1157.278
#107	RUNX3	30	8	38	178.042
#108	EGR2	30	19	49	1199.095
#109	MAF	29	13	42	376.109
#110	NFIC	29	17	46	640.89
#111	TFAM	29	18	47	2747.071
#112	NFATC3	29	24	53	1741.966
#113	GTF2I	29	18	47	1210.931
#114	MYOD1	29	20	49	894.299
#115	TFE3	29	17	46	924.018
#116	NR2F6	29	15	44	289.874
#117	SPI1	29	22	51	1184.795
#118	FLI1	29	16	45	1704.29
#119	CITED2	29	16	45	1409.02
#120	MZF1	28	12	40	185.742
#121	NR4A2	28	21	49	1100.063
#122	SOX18	28	18	46	3242.266
#123	NR2C2	28	30	58	1989.842
#124	FOXC2	28	12	40	360.297
#125	TBX4	28	20	48	1737.435
#126	HSF4	28	20	48	690.526
#127	CUX1	27	22	49	691.438
#128	TFEC	27	17	44	1781.419
#129	NFAT5	27	21	48	616.664
#130	ERG	27	17	44	503.669
#131	MEF2C	27	10	37	239.132
#132	KLF6	27	23	50	677.956
#133	E2F4	27	19	46	1145.143
#134	TRIM29	27	13	40	183.269
#135	NANOG	27	18	45	936.865
#136	NFIX	27	21	48	2826.534
#137	SATB1	26	20	46	993.739
#138	MEOX2	26	17	43	337.451
#139	YEATS4	26	21	47	754.222
#140	TCFL5	26	20	46	1396.36
#141	TCF7	26	19	45	908.738
#142	TWIST1	26	14	40	242.59
#143	MYF6	26	24	50	977.276
#144	PEG3	26	26	52	1454.401
#145	TFEB	25	12	37	753.079
#146	ARNTL2	25	16	41	752.256
#147	OLIG2	25	22	47	1333.114
#148	RXRA	25	20	45	1537.263
#149	SOX9	25	16	41	940.156
#150	FOXN3	25	15	40	622.802
#151	ZNF140	25	17	42	397.031
#152	NFIB	25	21	46	1135.286
#153	MBD1	25	15	40	844.206
#154	MYT1	25	17	42	1444.82
#155	STAT1	24	14	38	318.519
#156	EHF	24	19	43	782.894
#157	HOXA4	24	20	44	1797.945
#158	CBL	24	27	51	1523.996
#159	CREB3L1	23	19	42	210.006
#160	ZNF132	23	23	46	1610.248
#161	KLF15	23	16	39	2140.174
#162	PKNOX2	23	25	48	2195.686
#163	ZKSCAN5	23	20	43	1499.552
#164	PPBPL2	23	28	51	756.76
#165	ASCL2	23	22	45	1114.015
#166	E2F1	23	20	43	367.245
#167	POU3F2	23	22	45	1100.465
#168	ELF5	22	15	37	448.772
#169	TBX10	22	20	42	1320.387
#170	SOX21	22	21	43	1175.35
#171	MSRB2	22	13	35	481.373
#172	EGR1	22	22	44	651.85
#173	ZGPAT	22	20	42	362.11
#174	T	22	27	49	1411.797
#175	ZFP36L2	22	30	52	1251.433
#176	ZNF117	22	25	47	1498.066
#177	TRPS1	22	15	37	632.385
#178	ONECUT2	21	24	45	1966.158
#179	FOXF1	21	23	44	1327.888
#180	MECOM	21	24	45	691.87
#181	SCAND2	21	26	47	1022.766
#182	E2F5	21	23	44	873.508
#183	SIX3	21	13	34	802.757
#184	BCL6	21	17	38	1307.97
#185	MEF2A	21	20	41	928.514
#186	HOXD11	20	23	43	1062.906
#187	ZNF24	20	25	45	1513.509
#188	ETV1	20	18	38	348.863
#189	ZIC3	20	25	45	1972.516
#190	CEBPE	20	23	43	1143.718
#191	ETS2	20	18	38	1121.763
#192	FOS	20	16	36	498.13
#193	E2F8	20	19	39	361.807
#194	SMAD3	20	22	42	501.069
#195	HOPX	20	18	38	1264.201
#196	MSX1	20	21	41	1019.235
#197	HOXD1	20	33	53	1132.43
#198	MMP14	20	24	44	661.144
#199	STAT6	20	32	52	2159.618
#200	RXRB	20	21	41	1592.692
#201	TAF5	20	17	37	890.63
#202	HOXB9	19	21	40	1183.968
#203	MYBL2	19	14	33	364.992
#204	PDX1	19	25	44	877.18
#205	ELF4	19	15	34	345.016
#206	ATF6B	19	19	38	510.597
#207	ZNF175	19	21	40	1528.714
#208	BNC1	19	17	36	1418.022
#209	TEAD4	19	17	36	441.283
#210	NR2F2	19	29	48	1067.582
#211	PGR	19	20	39	369.958
#212	HOXA3	19	27	46	831.188
#213	CBFA2T2	19	21	40	761.39
#214	ZNF80	19	32	51	1590.115
#215	HMGA1	19	13	32	231.335
#216	ESRRB	19	19	38	790.84
#217	LMO4	19	15	34	259.392
#218	NR2E3	19	21	40	871.152
#219	TBX2	19	19	38	823.293
#220	MTA2	18	17	35	670.167
#221	PHOX2A	18	23	41	1210.997
#222	HSF2	18	18	36	1048.167
#223	ZFHX3	18	28	46	487.208
#224	ZKSCAN4	18	17	35	642.054
#225	NR5A1	18	18	36	483.409
#226	MXD1	18	20	38	1421.019
#227	HOXC8	18	28	46	1026.33
#228	ESRRG	18	23	41	1132.653
#229	VTN	18	34	52	1970.261
#230	FOXO3	18	17	35	591.73
#231	TBX19	18	18	36	737.395
#232	TFAP2B	17	17	34	561.71
#233	NR2F1	17	26	43	1257.856
#234	HOXA9	17	14	31	340.306
#235	HOXA10	17	21	38	771.646
#236	CITED1	17	22	39	572.846
#237	ZNF41	17	28	45	914.268
#238	ZNF45	17	28	45	967.837
#239	HEY1	17	17	34	720.577
#240	ZNF643	17	25	42	1248.487
#241	GATA2	17	28	45	1046.536
#242	MAFK	17	27	44	886.383
#243	SCRT1	17	19	36	642.661
#244	RARG	17	27	44	1470.378
#245	TRIM25	17	18	35	662.59
#246	MLXIPL	17	29	46	1456.215
#247	ELF2	17	25	42	1014.702
#248	PRDM1	17	23	40	1125.307
#249	NRL	17	33	50	1603.67
#250	NKX3-2	17	22	39	1056.032
#251	CEBPD	17	25	42	553.84
#252	SMAD5	17	22	39	350.741
#253	ZKSCAN1	17	22	39	1067.405
#254	GATA4	16	24	40	548.873
#255	NKX2-5	16	22	38	399.767
#256	FOXH1	16	29	45	2335.645
#257	ZNF154	16	27	43	1465.884
#258	IKZF1	16	22	38	850.784
#259	TBX6	16	24	40	1040.142
#260	RUNX1T1	16	16	32	431.371
#261	NEUROG1	16	20	36	912.448
#262	BRD8	16	28	44	814.601
#263	TP53	16	26	42	767.771
#264	HOXB2	16	15	31	151.322
#265	ZNF446	16	16	32	233.77
#266	ZBTB48	16	27	43	901.692
#267	PPARA	16	24	40	2558.729
#268	ZNF202	16	25	41	625.211
#269	TFDP3	16	23	39	1127.436
#270	TAF1B	16	24	40	806.887
#271	SOX5	16	26	42	1173.631
#272	PHTF1	16	19	35	1931.741
#273	HNF1B	15	28	43	616.108
#274	CSRNP3	15	21	36	758.385
#275	BLZF1	15	21	36	678.815
#276	TBX5	15	26	41	1070.54
#277	LHX2	15	27	42	793.936
#278	TEAD3	15	30	45	1256.086
#279	ZNF187	15	26	41	1087.938
#280	HINFP	15	28	43	471.817
#281	SALL1	15	31	46	1286.421
#282	SOX13	15	21	36	555.364
#283	ZIC1	15	16	31	94.34
#284	SOX17	15	26	41	859.647
#285	NR4A1	15	20	35	336.414
#286	ZNF287	15	25	40	1824.013
#287	TBX3	15	16	31	201.726
#288	KLF5	15	19	34	1004.424
#289	GATA6	15	21	36	915.118
#290	POU2F2	15	25	40	1020.411
#291	MSX2	15	24	39	461.038
#292	HIC1	15	20	35	548.701
#293	ZHX3	15	30	45	971.382
#294	HOXB6	15	18	33	497.548
#295	ZNF500	15	21	36	751.775
#296	ETV5	14	24	38	273.482
#297	ZNF174	14	19	33	297.684
#298	HOXA7	14	27	41	1064.894
#299	E2F2	14	27	41	714.743
#300	TADA2A	14	26	40	1076.394
#301	PAX3	14	28	42	907.543
#302	DBP	14	27	41	1101.522
#303	TLX2	14	27	41	774.388
#304	NR6A1	14	26	40	1260.835
#305	POU3F1	14	24	38	625.051
#306	HMG20B	14	22	36	440.598
#307	TFDP2	14	22	36	577.883
#308	NEUROD1	14	20	34	651.556
#309	POU3F3	14	19	33	1085.713
#310	ESR2	14	27	41	610.066
#311	TEF	14	22	36	653.405
#312	RFXAP	14	32	46	1306.092
#313	ARNTL	14	31	45	974.91
#314	PRDM2	14	29	43	1196.465
#315	HESX1	14	17	31	414.667
#316	ZNF236	14	29	43	1723.303
#317	VSX1	14	22	36	1075.367
#318	ETV2	14	32	46	963.026
#319	HOXC10	14	20	34	575.971
#320	HNF1A	13	28	41	877.761
#321	KLF4	13	31	44	798.028
#322	ZNF444	13	19	32	206.001
#323	HOXB7	13	13	26	567.47
#324	ASCL1	13	30	43	525.915
#325	HOXB8	13	20	33	534.917
#326	RARA	13	23	36	406.803
#327	TCF7L2	13	24	37	415.051
#328	NR1H4	13	24	37	514.336
#329	SIM2	13	21	34	575.384
#330	HOXB1	13	23	36	460.869
#331	NR0B1	13	29	42	1942.31
#332	DLX6	13	26	39	1107.2
#333	C2orf3	13	25	38	481.953
#334	HES1	13	23	36	703.294
#335	DMRT1	13	28	41	696.325
#336	SNAPC4	13	22	35	966.971
#337	KDM5B	13	28	41	967.021
#338	GABPB1	13	22	35	479.086
#339	NKX2-8	12	24	36	1046.134
#340	FOSL1	12	24	36	520.285
#341	LHX5	12	20	32	498.397
#342	NR3C2	12	24	36	608.627
#343	ZNF3	12	24	36	625.996
#344	POU6F1	12	33	45	703.289
#345	HIF3A	12	28	40	724.117
#346	FOXD1	12	23	35	545.834
#347	TFAP2C	12	29	41	703.595
#348	ZFP36L1	12	21	33	392.281
#349	PAX6	12	27	39	660.946
#350	FOXE1	12	24	36	879.827
#351	GBX2	12	27	39	809.212
#352	SP140	12	14	26	792.163
#353	FOXD3	12	21	33	828.653
#354	ETS1	12	31	43	1087.207
#355	SMAD1	12	27	39	670.092
#356	RUNX2	12	16	28	516.675
#357	HMX1	12	30	42	899.652
#358	STRN3	12	22	34	299.541
#359	SP1	12	23	35	804.251
#360	FOXI1	12	29	41	1277.552
#361	ZNF157	12	24	36	780.594
#362	CREBZF	12	34	46	1545.047
#363	JUN	12	21	33	356.12
#364	RERE	12	23	35	748.956
#365	NR2C1	11	27	38	1149.067
#366	LHX1	11	21	32	509.631
#367	SCML1	11	21	32	657.539
#368	NKX3-1	11	21	32	648.226
#369	BARX1	11	21	32	677.963
#370	ARNT	11	24	35	776.949
#371	POU3F4	11	22	33	765.301
#372	HEY2	11	28	39	350.799
#373	RBPJL	11	23	34	533.638
#374	PRRX2	11	25	36	1502.617
#375	PKNOX1	11	31	42	1291.368
#376	SOX30	11	26	37	1087.7
#377	FOXD2	11	27	38	1563.652
#378	ONECUT1	11	23	34	512.123
#379	HOXA2	11	30	41	877.763
#380	HNF4A	11	23	34	499.064
#381	ZNF238	11	30	41	1706.351
#382	FOSB	11	9	20	175.239
#383	ZNF81	11	33	44	1471.224
#384	PAX4	11	28	39	742.157
#385	POU6F2	11	28	39	514.483
#386	ZFP37	11	28	39	1145.287
#387	HOXC13	11	23	34	458.228
#388	FOSL2	11	30	41	590.101
#389	ZXDC	11	33	44	578.635
#390	VDR	11	30	41	1026.148
#391	SLC26A3	10	28	38	409.823
#392	FOXO4	10	32	42	1657.919
#393	IKZF3	10	26	36	1044.494
#394	ZNF75D	10	25	35	577.774
#395	MLL	10	23	33	945.452
#396	SOX2	10	27	37	604.358
#397	IRF5	10	27	37	794.128
#398	KLF12	10	31	41	706.686
#399	POU5F1B	10	23	33	346.602
#400	FOXA2	10	29	39	1011.47
#401	TSC22D2	10	18	28	546.118
#402	ZNF155	10	30	40	754.973
#403	HOXB3	10	25	35	447.709
#404	USF2	10	24	34	563.385
#405	LEF1	10	30	40	820.002
#406	MYCL1	10	25	35	633.26
#407	PPARG	10	20	30	362.797
#408	POU2F3	10	33	43	826.68
#409	SNAPC5	10	29	39	1121.194
#410	POU1F1	10	31	41	797.779
#411	LZTS1	10	27	37	777.014
#412	SRY	9	28	37	676.785
#413	HOXD13	9	26	35	568.065
#414	MYCN	9	25	34	458.544
#415	CUX2	9	24	33	680.62
#416	ELK1	9	28	37	628.24
#417	SIX1	9	29	38	737.394
#418	RCAN1	9	28	37	984.388
#419	ST18	9	28	37	614.934
#420	ERF	9	23	32	495.018
#421	TFAP2A	9	24	33	651.466
#422	ALX3	9	20	29	318.226
#423	RB1	9	34	43	880.568
#424	TBX1	9	35	44	1756.617
#425	MNX1	9	34	43	712.224
#426	FOXG1	9	26	35	496.599
#427	PROX1	9	22	31	1201.981
#428	ZEB1	9	24	33	260.376
#429	FOXP3	9	35	44	922.907
#430	SATB2	9	33	42	1963.39
#431	MLLT10	9	23	32	301.001
#432	EMX1	9	25	34	370.332
#433	SMAD6	9	29	38	582.396
#434	THRA	9	30	39	465.019
#435	FOXL2	9	22	31	425.87
#436	EGR4	9	32	41	667.283
#437	PHF1	9	28	37	459.736
#438	TSC22D3	9	32	41	894.573
#439	NFKB2	9	22	31	436.228
#440	ATOH1	8	27	35	599.745
#441	NFX1	8	30	38	745.827
#442	SIM1	8	24	32	433.149
#443	MYF5	8	33	41	572.772
#444	CREBBP	8	25	33	1101.077
#445	WNT5A	8	29	37	602.811
#446	PTH	8	28	36	850.632
#447	ZSCAN12	8	19	27	329.012
#448	WT1	8	31	39	850.675
#449	PLAG1	8	34	42	1165.078
#450	EN2	8	25	33	689.134
#451	TP63	8	26	34	555.366
#452	TCF15	7	30	37	745.052
#453	FOXB1	7	29	36	444.737
#454	NPAS2	7	24	31	899.402
#455	TCF12	7	28	35	393.194
#456	IRF4	7	35	42	865.453
#457	TAF13	7	32	39	1439.999
#458	CREM	7	25	32	449.248
#459	ETV4	7	25	32	423.071
#460	ZSCAN18	7	29	36	586.635
#461	NPAS1	7	31	38	778.436
#462	NKX2-1	7	30	37	627.435
#463	PPARD	7	26	33	535.013
#464	PAX5	7	25	32	428.788
#465	CREB5	7	30	37	510.265
#466	FOXJ1	7	32	39	657.871
#467	RARB	7	28	35	572.129
#468	NR1I2	7	24	31	722.003
#469	YY1	6	28	34	421.648
#470	HOXD3	6	32	38	342.698
#471	TLX3	6	28	34	285.536
#472	IRX4	6	35	41	946.014
#473	HNF4G	6	24	30	500.014
#474	PITX1	6	30	36	200.492
#475	BATF3	6	25	31	979.716
#476	HOXA11	6	21	27	149.628
#477	GSC2	6	28	34	664.034
#478	ZNF135	6	33	39	391.133
#479	C11orf9	6	28	34	406.706
#480	MSC	6	25	31	329.277
#481	STAT2	6	30	36	473.345
#482	POU4F1	5	28	33	515.99
#483	ATF5	5	34	39	380.358
#484	REST	5	32	37	295.371
#485	ELK4	5	28	33	480.794
#486	TCF21	5	29	34	588.644
#487	PAX8	5	26	31	262.821
#488	NFATC1	5	29	34	446.976
#489	ARID3A	5	27	32	600.703
#490	FOXE3	5	27	32	281.968
#491	ZNF167	4	35	39	316.006
#492	GCM1	4	31	35	227.235
#493	PITX2	3	32	35	166.905
#494	MYT1L	3	33	36	369.848
#495	ZNF639	3	29	32	597.851
#496	HLF	3	32	35	276.703
#497	ZNF134	3	29	32	257.493
#498	NR5A2	3	28	31	204.251
#499	POU4F3	2	35	37	223.897
#500	DLX2	2	32	34	60.519