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Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	POU4F2	130	2	132	607.483
#2	NPAT	110	4	114	361.432
#3	HMGA2	95	9	104	1350.858
#4	TCF7L1	94	4	98	684.161
#5	ATF7	89	8	97	2661.835
#6	FOXA1	82	1	83	17.339
#7	PHOX2B	82	5	87	583.776
#8	GATA3	76	4	80	63.283
#9	MAX	73	3	76	131.56
#10	HAND1	73	9	82	1174.469
#11	SPIB	71	9	80	2337.453
#12	AFF1	67	5	72	509.139
#13	HCLS1	64	3	67	269.601
#14	ESR1	64	5	69	46.819
#15	XBP1	64	3	67	22.989
#16	KLF15	63	9	72	1982.225
#17	MBD1	63	11	74	1663.286
#18	JUND	62	13	75	599.177
#19	TAL1	62	3	65	204.204
#20	SPDEF	62	6	68	110.239
#21	NFE2	62	1	63	346.982
#22	BLZF1	62	17	79	4605.483
#23	TBR1	60	10	70	517.455
#24	SP4	58	16	74	3695.121
#25	ZFPM2	58	9	67	1559.925
#26	TSHZ2	57	13	70	701.557
#27	SNAI2	56	4	60	583.021
#28	AR	56	4	60	41.261
#29	E2F3	56	8	64	6011.976
#30	ADNP2	55	11	66	1384.827
#31	PKNOX1	55	6	61	261.035
#32	TAF12	55	7	62	862.212
#33	NFYC	55	7	62	1284.661
#34	TADA3	54	13	67	2546.186
#35	FOXC1	53	2	55	4931.67
#36	IRX5	52	9	61	8337.316
#37	HOXA11	52	17	69	746.497
#38	YBX1	51	8	59	7814.259
#39	E2F6	50	14	64	826.001
#40	EN1	50	6	56	40.887
#41	KLF2	50	7	57	660.423
#42	BHLHE40	48	9	57	267.739
#43	NFYB	48	20	68	4166.067
#44	GABPA	48	13	61	1027.56
#45	SUPT6H	47	9	56	265.637
#46	NFATC3	46	19	65	784.275
#47	STAT3	45	9	54	378.225
#48	GTF2I	45	8	53	2713.09
#49	REXO4	45	10	55	491.053
#50	MZF1	45	10	55	1237.459
#51	NFE2L1	44	13	57	1011.377
#52	CITED2	44	12	56	886.118
#53	FOXM1	44	8	52	239.436
#54	ARNTL	43	13	56	757.902
#55	IRF8	43	1	44	2007.802
#56	FLI1	43	4	47	237.679
#57	ZGPAT	43	14	57	342.866
#58	MYC	42	12	54	368.382
#59	LASS6	42	9	51	100.206
#60	CTBP1	42	9	51	775.786
#61	ENO1	41	16	57	2648.467
#62	MEF2C	41	8	49	779.913
#63	CNOT8	41	16	57	2933.803
#64	AEBP1	41	7	48	209.412
#65	CREBZF	40	18	58	950.297
#66	SOX10	39	9	48	139.142
#67	ZNF165	39	23	62	1015.683
#68	NFYA	39	15	54	726.507
#69	HDAC2	38	9	47	1073.422
#70	SPI1	37	11	48	1664.628
#71	HMGA1	37	7	44	61.206
#72	TCF4	37	13	50	1894.45
#73	EPAS1	37	9	46	234.686
#74	CSDA	36	11	47	8852.461
#75	TRIM22	36	6	42	636.387
#76	HSF4	36	19	55	1497.7
#77	CEBPB	36	13	49	388.736
#78	FOXO1	36	13	49	1384.674
#79	MGA	36	11	47	301.768
#80	HOXC5	35	17	52	1978.229
#81	RUNX2	35	17	52	2159.91
#82	REST	34	17	51	727.298
#83	HNF1B	34	12	46	478.156
#84	SIM2	33	23	56	1172.905
#85	CBFB	33	9	42	542.148
#86	TFE3	33	19	52	2270.269
#87	CDKN2A	33	11	44	6966.824
#88	ZIC3	33	17	50	1390.981
#89	NR3C1	32	16	48	2207.309
#90	MAFF	32	15	47	769.849
#91	NFAT5	32	13	45	313.579
#92	BCL6	32	12	44	564.405
#93	AHR	32	13	45	1787.645
#94	SATB1	32	18	50	5025.305
#95	POU6F1	32	9	41	400.603
#96	ETV1	32	12	44	547.937
#97	VENTX	31	19	50	805.197
#98	SOX11	31	14	45	653.17
#99	ARNT	31	16	47	624.887
#100	STRN3	31	23	54	1135.812
#101	SOX17	31	18	49	1788.712
#102	ZXDC	31	15	46	457.44
#103	HES1	31	11	42	205.455
#104	NR2E1	31	20	51	4431.783
#105	ARNTL2	30	16	46	1226.979
#106	YEATS4	30	16	46	1164.077
#107	HOXD12	30	11	41	1390.622
#108	MEIS3P1	30	6	36	545.038
#109	RFX3	30	15	45	1086.867
#110	LMO4	30	12	42	236.198
#111	ZNF446	30	12	42	378.814
#112	HMGB2	30	12	42	578.38
#113	ZEB2	29	22	51	2525.618
#114	PBX2	29	17	46	870.809
#115	ZNF45	29	20	49	2101.074
#116	PLSCR1	28	8	36	163.634
#117	NFIB	28	18	46	871.251
#118	ELF1	28	23	51	1838.208
#119	ESRRA	28	15	43	1766.535
#120	STAT1	28	14	42	796.442
#121	HOXA5	27	16	43	417.117
#122	MXD1	27	11	38	256.606
#123	KLF6	27	18	45	953.625
#124	MLLT10	27	25	52	742.829
#125	ZNF83	27	15	42	1748.872
#126	BTG2	27	13	40	304.208
#127	RUNX3	27	9	36	242.91
#128	BNC1	27	17	44	1831.24
#129	RARA	27	17	44	879.545
#130	PBX1	27	21	48	490.803
#131	FOXC2	27	11	38	526.077
#132	BHLHE41	26	21	47	893.079
#133	TLX2	26	20	46	1310.646
#134	FOXF1	26	24	50	1823.901
#135	ISL1	26	21	47	575.335
#136	TFAM	26	13	39	1421.671
#137	E2F4	26	12	38	262.121
#138	HOXD4	26	25	51	1974.262
#139	RXRA	26	19	45	1324.305
#140	ZBTB48	26	17	43	1286.964
#141	ETV5	26	14	40	388.022
#142	ESR2	26	23	49	1527.541
#143	SOX4	26	20	46	499.537
#144	POU3F4	26	25	51	1646.914
#145	E2F1	26	16	42	727.271
#146	GATA1	25	25	50	1709.82
#147	MEIS2	25	21	46	998.18
#148	FOS	25	14	39	339.065
#149	TP53	25	16	41	304.235
#150	HSF1	25	20	45	909.939
#151	ESRRG	25	20	45	964.604
#152	SMAD3	25	23	48	542.63
#153	ZSCAN18	25	11	36	1206.859
#154	HOXA9	24	15	39	800.585
#155	BCL11B	24	7	31	1076.235
#156	TP63	24	24	48	1111.822
#157	PPBPL2	24	22	46	671.991
#158	NR2F6	24	16	40	699.925
#159	SOX5	24	21	45	1749.299
#160	ZNF444	24	22	46	661.693
#161	ERG	24	12	36	489.654
#162	IKZF1	24	8	32	357.978
#163	MSX1	24	25	49	2108.711
#164	IKZF3	24	12	36	2116.487
#165	SP140	24	9	33	909.384
#166	SOX9	23	24	47	1783.181
#167	E2F8	23	12	35	2462.033
#168	TP73	23	23	46	2582.623
#169	MYBL2	23	9	32	655.371
#170	TBX10	23	21	44	897.548
#171	ZNF140	23	20	43	2330.912
#172	TFEC	23	10	33	559.526
#173	ZNF91	23	9	32	596.675
#174	KLF9	23	28	51	1965.913
#175	ASCL2	23	26	49	1201.819
#176	ZNF174	23	24	47	1196.433
#177	ZNF287	22	20	42	2407.61
#178	GATA2	22	18	40	585.657
#179	TCF7L2	22	26	48	884.009
#180	SREBF1	22	11	33	406.819
#181	HOPX	22	20	42	4638.349
#182	TAF5	22	16	38	1564.614
#183	GABPB1	22	18	40	671.507
#184	ETS1	21	25	46	2831.198
#185	RUNX1T1	21	21	42	1348.867
#186	HOXB2	21	18	39	581.33
#187	NR0B1	21	34	55	2522.175
#188	TBX2	21	16	37	978.063
#189	HIF1A	20	22	42	1698.62
#190	RXRB	20	16	36	268.631
#191	NR1I3	20	21	41	3264.274
#192	HIRA	20	22	42	1169.434
#193	FOXN3	20	25	45	2562.2
#194	ELF5	20	12	32	53.689
#195	NR2C2	20	27	47	1826.584
#196	KLF5	20	20	40	1282.254
#197	PKNOX2	20	19	39	478.563
#198	NEUROG1	20	19	39	446.678
#199	GAS7	20	27	47	491.599
#200	CSRNP3	19	24	43	353.877
#201	SNAPC4	19	15	34	575.089
#202	E2F5	19	27	46	1301.765
#203	WNT5A	19	23	42	680.846
#204	TFEB	19	19	38	551.837
#205	ELF4	19	19	38	660.268
#206	FOSB	19	9	28	626.469
#207	ELK3	19	23	42	859.168
#208	POU2F2	19	23	42	468.783
#209	MTA2	19	24	43	3177.984
#210	MMP14	18	27	45	814.875
#211	TRPS1	18	15	33	1076.434
#212	HOXA1	18	27	45	1261.844
#213	MEF2D	18	30	48	624.764
#214	PRDM2	18	22	40	634.311
#215	ATF6	18	20	38	605.995
#216	MAF	18	17	35	386.881
#217	BRD8	18	20	38	911.614
#218	HOXC8	17	24	41	766.128
#219	MAFB	17	16	33	470.33
#220	TBX3	17	14	31	194.748
#221	STAT6	17	21	38	1315.616
#222	JUN	17	20	37	716.769
#223	PDX1	17	31	48	1480.826
#224	MEOX1	17	28	45	1483.681
#225	STAT2	17	15	32	768.954
#226	TRIM29	17	12	29	105.198
#227	MYF6	17	29	46	1352.605
#228	SOX13	17	23	40	435.819
#229	PEG3	16	30	46	5686.27
#230	RFXAP	16	22	38	667.735
#231	MSX2	16	15	31	150.775
#232	ECSIT	16	14	30	244.239
#233	SMAD6	16	27	43	890.088
#234	TCF15	16	26	42	829.819
#235	CUX1	16	30	46	607.426
#236	NKX3-1	16	17	33	718.288
#237	C2orf3	16	20	36	514.408
#238	ZKSCAN1	16	20	36	576.527
#239	EGR2	16	20	36	577.491
#240	ONECUT1	16	24	40	942.485
#241	NR4A3	16	21	37	1180.084
#242	GATA4	16	19	35	818.405
#243	MLL	16	29	45	1219.515
#244	PPARA	16	30	46	2114.332
#245	C11orf9	16	25	41	881.61
#246	NFIX	15	16	31	612.137
#247	HINFP	15	20	35	639.279
#248	HNF4A	15	18	33	1723.639
#249	PRDM1	15	23	38	1706.499
#250	HOXC10	15	18	33	1217.447
#251	NR2E3	15	24	39	1004.097
#252	RUNX1	15	24	39	804.401
#253	MEOX2	15	20	35	840.768
#254	GLI2	15	26	41	1762.883
#255	KDM5B	15	24	39	11556.362
#256	TSC22D3	15	26	41	390.754
#257	PGR	15	14	29	126.071
#258	ONECUT2	15	22	37	1156.587
#259	CBFA2T2	15	24	39	265.867
#260	FOSL2	15	23	38	1062.654
#261	ST18	15	26	41	1827.03
#262	FOXI1	15	19	34	2184.538
#263	PROX1	15	30	45	1223.512
#264	TBX19	15	16	31	172.959
#265	TFAP2B	14	21	35	570.317
#266	HOXB6	14	14	28	274.57
#267	EHF	14	23	37	815.672
#268	HEY2	14	22	36	1263.201
#269	NEUROD1	14	30	44	684.366
#270	NKX2-5	14	16	30	188.079
#271	MYT1	14	24	38	755.428
#272	NR3C2	14	29	43	969.329
#273	NKX2-1	14	30	44	1287.715
#274	LHX1	14	26	40	1284.581
#275	TEAD4	14	19	33	864.688
#276	SMAD1	14	27	41	2617.694
#277	NANOG	14	22	36	1111.178
#278	PAX7	14	28	42	975.401
#279	POU3F1	14	21	35	676.517
#280	SIX2	14	24	38	651.196
#281	ATF3	14	18	32	470.064
#282	NRL	13	11	24	289.354
#283	HOXA10	13	31	44	953.58
#284	PHOX2A	13	19	32	682.311
#285	ZHX2	13	34	47	1859.203
#286	NR2C1	13	23	36	706.271
#287	ZFP36L2	13	28	41	411.658
#288	NR2F1	13	30	43	1735.612
#289	MECOM	13	24	37	431.919
#290	ZIC1	13	12	25	85.502
#291	CREB3L1	13	17	30	157.589
#292	HOXA7	13	27	40	873.843
#293	HOXB3	13	23	36	1097.656
#294	FOXO4	13	25	38	1150.705
#295	ZNF175	13	30	43	1467.945
#296	EGR4	13	25	38	877.421
#297	MEF2A	13	20	33	1521.276
#298	ZHX3	13	29	42	1622.332
#299	ALX3	12	25	37	588.023
#300	SRF	12	24	36	742.071
#301	NFKB2	12	27	39	400.714
#302	PRRX2	12	28	40	1006.975
#303	ELK1	12	19	31	931.79
#304	TBX6	12	34	46	1205.045
#305	HOXD1	12	27	39	705.334
#306	PAX6	12	13	25	112.097
#307	POU3F2	12	24	36	952.284
#308	ATF6B	12	26	38	2082.186
#309	MLXIPL	12	17	29	440.325
#310	DBP	12	25	37	880.123
#311	FOXD2	12	29	41	1422.563
#312	T	12	29	41	3513.28
#313	ZNF75D	12	20	32	939.612
#314	SCML1	12	28	40	2104.963
#315	ZNF154	12	30	42	712.901
#316	SOX21	12	22	34	773.988
#317	FOXO3	12	23	35	1212.653
#318	LZTS1	12	24	36	608.968
#319	NFX1	12	36	48	672.378
#320	SALL1	12	32	44	1937.868
#321	USF2	12	20	32	415.377
#322	MSRB2	12	24	36	659.043
#323	FOXE1	11	26	37	1058.586
#324	HOXA2	11	28	39	1695.541
#325	LHX6	11	20	31	1012.808
#326	MYT1L	11	23	34	372.021
#327	NR4A1	11	28	39	1561.7
#328	FOXJ1	11	28	39	3097.239
#329	TADA2A	11	23	34	421.76
#330	TFAP2A	11	24	35	561.249
#331	KLF12	11	27	38	3433.518
#332	NKX3-2	11	23	34	863.799
#333	ETV2	11	25	36	1551.742
#334	RERE	11	36	47	2374.659
#335	SLC26A3	11	28	39	543.703
#336	HOXB9	11	25	36	679.391
#337	PITX1	11	24	35	558.763
#338	HIF3A	11	25	36	853.209
#339	ZFHX3	11	25	36	396.553
#340	EGR1	11	14	25	633.334
#341	RBPJL	11	20	31	591.119
#342	IRF4	11	32	43	1366.376
#343	LEF1	11	19	30	348.387
#344	SIX3	11	18	29	248.938
#345	HOXB7	11	28	39	2548.858
#346	EGR3	11	16	27	537.277
#347	SOX30	11	34	45	2857.704
#348	SIX1	11	24	35	240.934
#349	CITED1	11	19	30	352.516
#350	EMX1	11	22	33	688.71
#351	ARNT2	11	16	27	161.054
#352	NR4A2	11	28	39	905.827
#353	TCF3	10	23	33	260.688
#354	HOXB8	10	28	38	1133.324
#355	MYCN	10	38	48	1043.695
#356	TBX5	10	34	44	1265.09
#357	TFDP3	10	25	35	270.621
#358	SCAND2	10	29	39	1309.548
#359	SIM1	10	33	43	1026.109
#360	ZNF202	10	21	31	1145.157
#361	POU5F1B	10	38	48	1103.931
#362	OLIG2	10	31	41	2086.004
#363	SOX18	10	21	31	680.199
#364	MYCL1	10	29	39	824.564
#365	SOX15	10	27	37	639.285
#366	HSF2	10	30	40	1142.397
#367	TWIST1	10	21	31	527.696
#368	PPARD	10	26	36	1796.227
#369	HOXD11	10	26	36	882.839
#370	HLF	9	22	31	671.528
#371	HOXD9	9	30	39	879.142
#372	NPAS2	9	32	41	1126.395
#373	TLX3	9	30	39	3301.258
#374	ATF5	9	27	36	3120.767
#375	RARG	9	27	36	1027.951
#376	HR	9	36	45	801.657
#377	IRX4	9	24	33	668.693
#378	BATF3	9	27	36	363.488
#379	SCRT1	9	27	36	556.671
#380	PHF1	9	31	40	776.442
#381	HIC1	9	24	33	324.641
#382	FOSL1	9	27	36	317.242
#383	CREBBP	9	30	39	753.168
#384	ZNF80	9	36	45	909.348
#385	YY1	9	27	36	1167.098
#386	POU4F3	9	29	38	1416.317
#387	BARX1	9	32	41	653.623
#388	MNX1	9	30	39	1127.986
#389	TAF13	9	32	41	1132.955
#390	PPARG	9	28	37	1321.595
#391	NR2F2	9	32	41	798.942
#392	CUX2	9	30	39	2202.484
#393	PHTF1	8	26	34	823.103
#394	POU1F1	8	38	46	949.834
#395	E2F2	8	25	33	244.597
#396	NR5A1	8	32	40	965.16
#397	VTN	8	30	38	613.551
#398	VDR	8	21	29	606.48
#399	ZNF117	8	24	32	713.401
#400	GATA6	8	24	32	492.222
#401	EN2	8	31	39	2034.43
#402	DLX2	8	34	42	1107.869
#403	HOXA4	8	24	32	1302.473
#404	HOXB1	8	30	38	624.945
#405	FOXB1	8	30	38	548.538
#406	HNF1A	8	31	39	880.733
#407	ZFP37	8	25	33	489.929
#408	TRIM25	8	28	36	586.7
#409	HEY1	8	23	31	650.897
#410	PAX8	8	25	33	938.03
#411	SP1	8	29	37	706.65
#412	OVOL1	8	35	43	4095.882
#413	MYF5	8	28	36	929.938
#414	NKX2-8	8	27	35	1091.53
#415	KLF4	8	24	32	692.238
#416	ZNF238	8	29	37	1006.197
#417	DMRT1	8	26	34	1604.667
#418	ELK4	7	25	32	793.694
#419	CEBPE	7	21	28	1026.68
#420	SATB2	7	37	44	1252.492
#421	TCF7	7	14	21	46.809
#422	POU6F2	7	25	32	1099.848
#423	TAF1B	7	26	33	271.031
#424	TFAP2C	7	31	38	337.745
#425	ZNF134	7	19	26	522.463
#426	RCAN1	7	25	32	470.829
#427	NR1H4	7	30	37	397.762
#428	NR1I2	7	31	38	2247.938
#429	PLAG1	7	27	34	402.732
#430	HMG20B	7	22	29	278.511
#431	HNF4G	7	30	37	469.209
#432	ZNF323	7	28	35	375.058
#433	FOXA2	7	31	38	995.64
#434	NR6A1	7	26	33	292.674
#435	ZNF81	7	30	37	994.138
#436	TSC22D2	7	30	37	234.072
#437	LHX2	7	28	35	502.434
#438	HOXC13	7	24	31	454.735
#439	ESRRB	7	30	37	491.749
#440	SOX2	6	32	38	375.138
#441	SRY	6	36	42	917.297
#442	ZNF3	6	32	38	664.755
#443	ZNF135	6	29	35	2660.094
#444	TFDP2	6	29	35	155.275
#445	RB1	6	32	38	512.747
#446	POU4F1	6	30	36	1304.595
#447	FOXG1	6	25	31	274.126
#448	PAX5	6	30	36	965.662
#449	DLX6	6	25	31	1018.481
#450	ZNF157	6	36	42	893.35
#451	FOXH1	6	22	28	150.264
#452	HOXD13	6	32	38	432.466
#453	ZNF155	6	26	32	244.022
#454	ZNF236	6	34	40	618.148
#455	PTH	6	34	40	702.039
#456	POU2F3	6	27	33	271.4
#457	MSC	6	33	39	801.778
#458	ZFP36L1	6	22	28	800.775
#459	TCF12	6	26	32	1066.922
#460	ERF	6	27	33	564.564
#461	FOXD3	6	27	33	474.33
#462	FOXL2	6	30	36	309.275
#463	FOXP3	6	26	32	544.459
#464	TEF	5	27	32	693.646
#465	HOXD3	5	39	44	646.293
#466	ASCL1	5	24	29	625.777
#467	ZEB1	5	29	34	555.145
#468	ATOH1	5	30	35	571.595
#469	ZNF41	5	32	37	597.666
#470	HOXA3	5	27	32	304.277
#471	GBX2	5	33	38	685.556
#472	CREM	5	26	31	617.8
#473	PITX2	5	25	30	495.438
#474	IRF5	5	21	26	524.238
#475	FOXD1	5	27	32	219.248
#476	ZNF643	5	30	35	398.113
#477	SNAPC5	5	34	39	492.24
#478	ZNF639	5	34	39	431.23
#479	POU3F3	5	29	34	676.348
#480	NFATC1	5	32	37	730.715
#481	WT1	4	32	36	370.989
#482	THRA	4	27	31	194.966
#483	RARB	4	34	38	698.268
#484	TCF21	4	30	34	304.972
#485	ARID3A	4	27	31	383.123
#486	HESX1	4	26	30	157.918
#487	TBX1	4	32	36	482.473
#488	ZSCAN12	4	24	28	332.735
#489	ZNF167	4	27	31	305.468
#490	GCM1	4	34	38	621.834
#491	NFATC4	4	26	30	295.414
#492	ETV4	4	29	33	398.913
#493	ALS2CR8	4	29	33	416.183
#494	NPAS1	4	34	38	272.67
#495	CREB5	4	23	27	128.565
#496	NR5A2	3	36	39	375.704
#497	PAX4	3	26	29	232.896
#498	MAFK	3	31	34	167.01
#499	PAX3	2	31	33	95.856
#500	GSC2	1	33	34	155.583