Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	CEBPA	88	4	92	1693.329
#2	TSC22D3	85	6	91	1600.063
#3	SIX4	84	5	89	1448.456
#4	HHEX	76	4	80	224.038
#5	FOXA1	75	3	78	1003.712
#6	IRF9	73	5	78	1254.062
#7	FOXQ1	65	4	69	621.8
#8	RUNX2	64	7	71	5845.661
#9	HOXB7	63	6	69	2852.872
#10	ETS1	57	5	62	1042.27
#11	NFE2L3	50	7	57	2507.455
#12	ETV6	46	4	50	1848.157
#13	ZSCAN18	46	8	54	1773.082
#14	DRAP1	45	8	53	2598.164
#15	FOXD1	45	16	61	7044.979
#16	TWIST1	44	9	53	2567.962
#17	NKX3-1	44	7	51	454.288
#18	ZIC2	43	8	51	628.229
#19	KLF9	43	8	51	2950.73
#20	ZNF69	42	10	52	4526.05
#21	NFIX	42	10	52	1242.984
#22	FOXA3	41	7	48	737.23
#23	ZFPM1	41	8	49	1946.521
#24	GATA2	40	13	53	2612.584
#25	FOXA2	39	10	49	1962.852
#26	PLSCR1	39	9	48	646.408
#27	LASS6	39	7	46	3153.97
#28	ISL1	38	10	48	3860.198
#29	TSC22D1	37	12	49	3703.27
#30	FOXL2	36	10	46	2096.053
#31	IRF1	36	14	50	2997.854
#32	HOXB2	33	12	45	2463.495
#33	ZEB2	32	10	42	462.186
#34	FOXF2	32	10	42	1322.564
#35	MECOM	31	10	41	1235.75
#36	HNF1B	31	8	39	1180.814
#37	HOXA2	30	11	41	3451.974
#38	NPAS2	30	13	43	2766.851
#39	MYC	30	12	42	2678.507
#40	HEYL	29	8	37	964.457
#41	SMAD6	29	16	45	5646.636
#42	PRRX2	29	7	36	1583.404
#43	ETV5	29	12	41	1244.919
#44	FLI1	28	4	32	1750.708
#45	RXRA	28	9	37	331.329
#46	HOXA5	28	7	35	1974.36
#47	HOXB9	28	10	38	1135.233
#48	HOXC8	27	5	32	517.078
#49	FOXC1	27	7	34	16795.715
#50	TEAD2	27	11	38	1539.301
#51	SOX9	26	12	38	2995.418
#52	PGBD1	26	4	30	468.607
#53	IRF8	26	9	35	579.291
#54	ELK3	26	12	38	1943.474
#55	XBP1	25	10	35	902.425
#56	MSX1	25	10	35	2634.313
#57	GLI2	25	15	40	2786.216
#58	ZNF323	25	9	34	11190.771
#59	ZHX2	25	14	39	2515.211
#60	STAT1	24	11	35	1595.876
#61	MNX1	24	9	33	1850.278
#62	ELF3	24	14	38	1819.903
#63	PRDM1	23	13	36	2296.505
#64	ZNF134	23	9	32	787.487
#65	HOXC6	23	11	34	3834.075
#66	BCL6	23	11	34	5723.56
#67	IRX5	23	10	33	711.331
#68	LBX2	23	12	35	12996.993
#69	HOXB8	22	12	34	874.544
#70	NR2F1	22	12	34	1488.362
#71	FOSL1	22	8	30	309.469
#72	KLF12	22	9	31	2120.211
#73	LHX2	21	13	34	2054.655
#74	ZFP90	21	15	36	1988.426
#75	PBX4	20	10	30	910.561
#76	SP140	20	7	27	296.313
#77	ZNF256	20	9	29	770.116
#78	SIM2	20	14	34	3993.83
#79	NR1H3	19	12	31	5011.263
#80	ELF5	19	8	27	1040.417
#81	POU5F1	19	13	32	931.534
#82	NKX3-2	19	8	27	801.432
#83	KLF5	19	8	27	355.398
#84	TFDP2	19	10	29	1553.794
#85	WNT5A	19	14	33	6109.593
#86	HOXC13	19	10	29	1236.887
#87	VAV1	19	13	32	2484.657
#88	FOXO1	19	12	31	2892.893
#89	RFXAP	18	11	29	1509.865
#90	RUNX3	18	12	30	937.588
#91	ZNF91	18	15	33	44574.816
#92	IRX3	18	5	23	267.781
#93	STAT5A	18	11	29	1030.201
#94	GLI3	18	11	29	841.682
#95	MESP1	17	12	29	1605.764
#96	HOXA13	17	8	25	908.962
#97	HOXB5	17	8	25	725.258
#98	ESRRG	17	11	28	2929.261
#99	TFAP2C	17	14	31	1482.664
#100	IRF7	17	14	31	12715.479
#101	RB1	17	9	26	423.312
#102	HIF1A	16	18	34	1587.46
#103	SNAI2	16	18	34	2003.754
#104	PLAG1	16	11	27	4238.984
#105	NR4A2	16	11	27	4402.23
#106	ZNF93	16	10	26	719.701
#107	HEY1	16	13	29	995.683
#108	HOXD11	16	12	28	2567.591
#109	NFATC1	16	5	21	210.06
#110	HES6	16	12	28	974.839
#111	BTG2	16	9	25	966.687
#112	DLX2	16	11	27	4488.968
#113	ARNT2	15	12	27	3896.485
#114	CSDA	15	11	26	608.962
#115	BNC1	15	9	24	1802.288
#116	ZNF438	15	14	29	924.022
#117	NKX2-5	15	13	28	1675.311
#118	SMAD4	15	7	22	455.439
#119	ZFP37	15	10	25	2900.176
#120	EPAS1	15	10	25	829.177
#121	ZNF83	15	11	26	3135.813
#122	PCGF6	15	11	26	829.415
#123	FOXC2	14	12	26	879.28
#124	HES1	14	13	27	873.436
#125	TRIM29	13	10	23	13366.777
#126	ZNF175	13	18	31	1444.051
#127	SP4	13	6	19	357.291
#128	CREB3L3	13	7	20	721.233
#129	NFIB	13	8	21	1630.384
#130	C5orf41	13	14	27	860.539
#131	TFCP2	13	9	22	3171.648
#132	ARID4A	13	17	30	2538.829
#133	ALX1	13	4	17	196.222
#134	HOXC10	13	11	24	1414.546
#135	E2F1	13	12	25	895.736
#136	TGIF1	12	12	24	789.048
#137	PHTF1	12	12	24	399.671
#138	ZRANB2	12	11	23	2019.591
#139	PAX8	12	13	25	2157.69
#140	ETS2	12	12	24	1279.174
#141	PBX1	12	9	21	743.949
#142	HOXA4	12	14	26	781.337
#143	ZNF140	12	10	22	1326.701
#144	DDIT3	12	17	29	2891.95
#145	GTF2H2	12	9	21	712.957
#146	C1orf85	12	10	22	1617.267
#147	ZNF215	12	11	23	516.044
#148	SOX4	12	10	22	2593.757
#149	KLF10	12	15	27	2962.297
#150	POU2F2	12	10	22	502.329
#151	ATF3	12	17	29	1631.785
#152	ATF7	12	15	27	19111.618
#153	PPARD	12	9	21	102.41
#154	FBXW7	11	13	24	3160.846
#155	ONECUT2	11	12	23	425.361
#156	EOMES	11	14	25	868.943
#157	TRIM22	11	15	26	1379.389
#158	MAF	11	9	20	368.861
#159	SOX18	11	15	26	2299.956
#160	FOXD4L1	11	14	25	3490.517
#161	SATB2	11	8	19	724.956
#162	TSHZ3	11	7	18	239.978
#163	HMGA2	11	12	23	626.187
#164	PITX1	11	10	21	1322.337
#165	BATF3	11	14	25	742.57
#166	SOX15	11	18	29	1759.524
#167	NFX1	11	15	26	4035.715
#168	TBX15	11	15	26	1015.859
#169	TCF21	10	9	19	168.069
#170	NR1D2	10	13	23	1064.092
#171	E2F2	10	12	22	3163.501
#172	HEY2	10	11	21	919.693
#173	CITED2	10	18	28	4106.88
#174	SALL2	10	14	24	1739.235
#175	HOXA10	10	7	17	693.039
#176	MEIS3	10	13	23	246.044
#177	HOXC4	10	16	26	1221.89
#178	EBF1	10	10	20	432.153
#179	CDKN2A	10	10	20	1157.188
#180	FOXF1	10	14	24	697.547
#181	GCFC1	10	14	24	1953.592
#182	OTX1	10	15	25	968.568
#183	HDAC2	10	8	18	363.556
#184	TBX1	9	8	17	362.634
#185	LHX4	9	9	18	496.921
#186	HOXA11	9	10	19	1190.865
#187	HOXD10	9	7	16	883.108
#188	MXD1	9	14	23	814.014
#189	ZFHX4	9	11	20	358.709
#190	HOXB4	9	14	23	641.26
#191	ZSCAN5A	9	14	23	14444.673
#192	GATA5	9	7	16	1983.265
#193	GATA3	9	13	22	978.909
#194	CREB5	9	13	22	2590.403
#195	MEIS1	9	12	21	685.314
#196	MKX	9	11	20	1115.832
#197	NR0B1	9	11	20	486.162
#198	MLXIPL	9	10	19	306.98
#199	TCF4	9	10	19	264.959
#200	ZNF33A	9	11	20	58016.564
#201	HOXC9	9	8	17	480.457
#202	BATF	9	9	18	311.682
#203	SREBF1	9	13	22	748.779
#204	ZNF165	9	11	20	9691.885
#205	SIX2	9	14	23	1266.278
#206	DBP	9	14	23	1247.928
#207	NFYB	9	16	25	1180.93
#208	SREBF2	9	13	22	278.162
#209	ESRRB	9	15	24	7875.544
#210	HNF4G	9	9	18	275.287
#211	NR3C2	9	12	21	626.784
#212	FOXP1	9	14	23	1024.868
#213	FOXE1	9	9	18	198.758
#214	C11orf9	9	11	20	895.996
#215	E2F5	8	16	24	2465.495
#216	ZXDA	8	12	20	1927.439
#217	TBX2	8	13	21	1206.276
#218	HSF1	8	12	20	1471.774
#219	ZFP36L1	8	14	22	263.751
#220	SMAD3	8	12	20	1459.873
#221	HCLS1	8	16	24	1405.925
#222	ZNF81	8	9	17	3029.121
#223	NR5A2	8	19	27	2260.662
#224	HOXB6	8	14	22	1076.375
#225	HESX1	8	11	19	775.794
#226	CTBP1	8	11	19	1729.256
#227	RORB	8	11	19	170.879
#228	FOXD2	8	13	21	561.797
#229	SOX12	8	13	21	233.231
#230	VDR	8	10	18	220.099
#231	ZNF483	8	9	17	1531.811
#232	RELB	7	18	25	447.246
#233	SCML2	7	13	20	1268.91
#234	HOXA9	7	15	22	1752.391
#235	MAX	7	12	19	244.881
#236	NR1H4	7	13	20	1341.287
#237	CREM	7	9	16	160.182
#238	CSRNP3	7	11	18	187.019
#239	TBX5	7	9	16	984.691
#240	HOXA3	7	13	20	388.962
#241	ZHX3	7	10	17	741.5
#242	BATF2	7	8	15	242.237
#243	LHX6	7	10	17	193.032
#244	TEF	7	14	21	426.07
#245	STAT4	7	17	24	1155.082
#246	EGR1	7	7	14	269.562
#247	IRF6	7	7	14	936.78
#248	TFDP3	7	7	14	299.725
#249	VSX1	7	13	20	31298.314
#250	HOMEZ	7	9	16	2422.742
#251	CITED1	7	10	17	252.433
#252	MSC	7	9	16	130.357
#253	HMGB2	7	14	21	500.635
#254	HOXB13	7	13	20	456.556
#255	SHOX	7	4	11	823.908
#256	ZNF643	7	15	22	3527.302
#257	FOSB	7	15	22	2296.086
#258	VTN	7	9	16	153.588
#259	ESR1	6	5	11	65.795
#260	ZNF71	6	11	17	326.238
#261	MEOX1	6	14	20	3026.061
#262	NFIA	6	15	21	809.746
#263	TP53	6	15	21	1131.906
#264	NR1D1	6	13	19	8225.145
#265	ZSCAN4	6	11	17	529.87
#266	TLX3	6	9	15	249.582
#267	ZNF274	6	11	17	566.264
#268	HOPX	6	9	15	913.049
#269	CREB3L1	6	8	14	819.632
#270	PRRX1	6	7	13	1150.74
#271	SOX6	6	10	16	232.567
#272	TFCP2L1	6	8	14	640.944
#273	MSX2	6	13	19	1377.718
#274	TADA2A	6	13	19	407.79
#275	ONECUT1	6	11	17	372.635
#276	TAL1	6	11	17	12791.998
#277	SCAND1	6	12	18	653.839
#278	ZNF167	6	5	11	603.297
#279	WT1	6	10	16	1201.737
#280	GRHL2	6	4	10	368.044
#281	AEBP1	6	9	15	463.372
#282	FOXP4	6	12	18	516.881
#283	PHOX2B	6	13	19	8782.577
#284	MAFF	6	17	23	2590.474
#285	PAX3	5	8	13	2316.189
#286	TBX3	5	10	15	126.522
#287	BCL11B	5	8	13	17942.249
#288	CTNNB1	5	11	16	105.246
#289	ELK4	5	13	18	136.14
#290	RUNX1T1	5	2	7	298.209
#291	RFX3	5	12	17	372.249
#292	ZEB1	5	14	19	434.464
#293	MITF	5	11	16	11790.734
#294	HOXD1	5	9	14	101.355
#295	ZSCAN20	5	17	22	1870.812
#296	TSHZ2	5	13	18	2101.339
#297	RCAN1	5	10	15	807.578
#298	DLX1	5	17	22	788.801
#299	ESX1	5	5	10	96.617
#300	NEUROG1	5	10	15	9362.313
#301	KLF15	5	9	14	154.046
#302	NKX6-1	5	17	22	2670.435
#303	TRERF1	5	13	18	481.872
#304	ZNF236	5	14	19	385.272
#305	SOX8	5	10	15	1012.133
#306	HOXC5	5	7	12	1158.059
#307	ZNF3	5	11	16	1372.195
#308	TFEC	5	7	12	686.3
#309	FOXR1	4	13	17	1600.33
#310	PHOX2A	4	11	15	124.558
#311	ZNF397	4	11	15	489.853
#312	ZNF445	4	14	18	183.049
#313	RCOR1	4	12	16	1124.881
#314	LEF1	4	15	19	183.699
#315	TGIF2LY	4	10	14	177.495
#316	PITX3	4	11	15	1191.824
#317	NEUROD1	4	9	13	307.275
#318	AR	4	13	17	119.96
#319	TBX21	4	13	17	1645.978
#320	HOXD12	4	9	13	7056.264
#321	MEF2C	4	16	20	198.85
#322	ZNF85	4	9	13	123.211
#323	ZSCAN2	4	18	22	626.703
#324	ASCL1	4	12	16	292.35
#325	RBPJ	4	11	15	135.705
#326	FOS	4	15	19	170.353
#327	PEG3	4	3	7	49.294
#328	MMP14	4	7	11	36.644
#329	FOXJ1	4	8	12	184.851
#330	CDX2	4	11	15	1392.152
#331	POU3F2	4	13	17	1736.42
#332	FOXN1	4	7	11	692.566
#333	MYT1L	4	10	14	1830.86
#334	HINFP	4	13	17	4194.341
#335	SP3	4	6	10	137.332
#336	NR2E1	4	7	11	505.764
#337	EN2	4	15	19	204.873
#338	ZNF192	4	18	22	657.425
#339	DLX3	4	15	19	1948.526
#340	ADNP	4	16	20	646.795
#341	ZNF132	4	13	17	257.328
#342	ETV2	4	11	15	92.29
#343	SMAD1	4	11	15	737.515
#344	IRF5	3	9	12	72.726
#345	ZNF135	3	15	18	647.138
#346	GATA4	3	13	16	10104.528
#347	BRD8	3	5	8	80.507
#348	ZNF197	3	9	12	79.801
#349	CNOT7	3	17	20	208.295
#350	SCMH1	3	13	16	1117.272
#351	SIX1	3	10	13	61.922
#352	RORC	3	13	16	719.893
#353	ZNF41	3	11	14	849.475
#354	KLF4	3	17	20	216.647
#355	TCF7	3	13	16	2743.946
#356	RARA	3	13	16	1406.858
#357	ZNF238	3	13	16	981.835
#358	TGIF2LX	3	8	11	514.316
#359	NFATC4	3	15	18	321.824
#360	HOXD13	3	13	16	2936.443
#361	TEAD4	3	14	17	9495.891
#362	EGR4	3	17	20	1556.733
#363	HR	3	9	12	96.181
#364	HSF4	3	14	17	666.437
#365	SOX7	3	15	18	148.612
#366	OVOL1	3	8	11	56.651
#367	PPARA	3	8	11	17869.896
#368	PAX6	3	11	14	147.834
#369	TP63	3	9	12	99.38
#370	ZSCAN10	3	12	15	315.85
#371	HLF	3	14	17	680.952
#372	SATB1	3	10	13	271.274
#373	NR4A1	3	15	18	56310.382
#374	SPI1	3	4	7	695.348
#375	ETV1	3	9	12	1038.071
#376	MAFB	3	17	20	120.648
#377	TFAP2A	3	13	16	131.418
#378	EGR2	3	17	20	214.629
#379	RORA	3	13	16	89.357
#380	LHX3	3	11	14	100.575
#381	DPRX	3	13	16	295.975
#382	ZNF80	3	10	13	840.777
#383	GLIS2	3	7	10	1552.288
#384	ZFPM2	3	11	14	611.338
#385	ARNTL	3	11	14	379.625
#386	HMX2	3	11	14	128.13
#387	GAS7	3	12	15	117.776
#388	MAFG	3	11	14	69
#389	ANKRD30A	3	11	14	1413.736
#390	POU5F2	2	11	13	1891.335
#391	ZNF70	2	10	12	104.764
#392	PROX1	2	8	10	1001.916
#393	NR4A3	2	9	11	1112.699
#394	NR1I2	2	8	10	62.744
#395	GRHL3	2	11	13	56.346
#396	RUNX1	2	16	18	154.699
#397	NKX2-3	2	10	12	34.567
#398	GBX2	2	15	17	56.724
#399	FOXN3	2	10	12	29.155
#400	ZNF169	2	7	9	157.761
#401	KCNH8	2	9	11	71.689
#402	MEIS2	2	15	17	3580.208
#403	SOX11	2	12	14	1935.827
#404	IRX6	2	13	15	321.114
#405	CUX1	2	17	19	288.12
#406	NEUROD2	2	10	12	580.819
#407	FEV	2	11	13	16418.259
#408	HAND2	2	11	13	1891.079
#409	NKX2-8	2	12	14	134.156
#410	RARB	2	16	18	242.088
#411	SOX5	2	12	14	633.846
#412	BACH2	2	5	7	19.222
#413	ZIC3	2	12	14	1698.697
#414	USF2	2	14	16	119.841
#415	HIF3A	2	12	14	628.411
#416	HOXC11	2	9	11	37.408
#417	TCF12	2	14	16	5180.999
#418	SOX17	2	6	8	50.026
#419	CBFA2T3	2	8	10	149.324
#420	SOX1	2	12	14	1527.003
#421	HOXD9	2	12	14	81.926
#422	LHX1	2	20	22	109.469
#423	FOXN4	2	8	10	68.427
#424	HIC1	2	8	10	205.456
#425	POU4F1	2	8	10	64.453
#426	SMAD9	2	19	21	140.086
#427	HAND1	2	7	9	69.283
#428	NFE2	2	20	22	1203.239
#429	HNF1A	2	10	12	16803.132
#430	PAX5	2	10	12	731.087
#431	PITX2	2	15	17	348.867
#432	POU2F3	2	10	12	48.518
#433	TCF7L1	1	11	12	35.52
#434	C2orf3	1	12	13	2963.669
#435	ZNF155	1	16	17	971.649
#436	NR2E3	1	8	9	390.013
#437	RHOXF1	1	14	15	680.44
#438	NRL	1	10	11	1190.844
#439	NANOG	1	11	12	30.823
#440	JUNB	1	10	11	557.681
#441	SPIB	1	10	11	108.285
#442	ZNF268	1	8	9	548.74
#443	PTH	1	11	12	1643.803
#444	CBFA2T2	1	16	17	77.666
#445	ZNF138	1	13	14	2164.927
#446	TEAD1	1	9	10	46.913
#447	NFATC2	1	13	14	9313.655
#448	FOXP2	1	7	8	771.847
#449	FOXE3	1	10	11	1614.924
#450	EGR3	1	12	13	1388.168
#451	EHF	1	14	15	24.736
#452	TFEB	1	8	9	77.594
#453	ZNF19	1	13	14	556.457
#454	TCEAL1	1	10	11	16.617
#455	TLX1	1	9	10	25.533
#456	PPARG	1	12	13	69.291
#457	NPAS1	1	15	16	958.114
#458	RARG	1	16	17	3256.372
#459	TBR1	1	11	12	15224.64
#460	ZIM2	1	9	10	45.082
#461	THRA	1	10	11	617.434
#462	MYT1	1	9	10	17.88
#463	POU1F1	1	12	13	32.761
#464	GSC	1	14	15	23.6
#465	NME2	1	14	15	35.983
#466	GSX2	1	13	14	1088.247
#467	HES5	1	12	13	113.904
#468	L3MBTL4	1	10	11	96.272
#469	ETV3L	1	14	15	3505.531
#470	FOXD4	1	10	11	38.909
#471	FOXR2	1	7	8	510.415
#472	ZFP42	1	13	14	179.46
#473	ZIC5	1	12	13	544.756
#474	GCM1	1	12	13	218.647
#475	HOXB3	1	15	16	77.204
#476	ZNF157	1	12	13	1464.135
#477	ZNF287	1	9	10	677.837
#478	IRX4	1	4	5	320.594
#479	IKZF1	1	10	11	127.143
#480	HOXD4	1	15	16	228.642
#481	SALL1	1	13	14	255.262
#482	ALS2CR8	1	11	12	44.938
#483	GLIS3	1	9	10	44.341
#484	BHLHE41	1	20	21	917.373
#485	ST18	1	6	7	39.541
#486	TPRX1	0	13	13	0
#487	SRY	0	9	9	0
#488	FOXB2	0	12	12	0
#489	FOXD3	0	15	15	0
#490	TCF20	0	8	8	0
#491	DLX4	0	12	12	0
#492	FOXS1	0	10	10	0
#493	SIM1	0	11	11	0
#494	ZNF92	0	11	11	0
#495	NKX6-2	0	9	9	0
#496	SOX21	0	9	9	0
#497	EMX1	0	9	9	0
#498	BACH1	0	9	9	0
#499	HNF4A	0	6	6	0
#500	ZNF449	0	11	11	0