Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	ZSCAN18	66	3	69	1451.187
#2	HIC1	57	5	62	423.999
#3	NFIA	57	13	70	3039.443
#4	ARNTL2	49	12	61	1389.298
#5	EHF	49	5	54	1099.288
#6	EPAS1	46	4	50	387.195
#7	HEYL	46	10	56	1875.621
#8	MSRB2	45	13	58	5651.904
#9	PBX1	44	3	47	256.869
#10	TCEAL1	43	6	49	1807.261
#11	TRIM22	43	10	53	998.567
#12	ELF1	43	9	52	2179.788
#13	HMGA1	43	13	56	2506.048
#14	SALL2	42	6	48	1011.573
#15	TSHZ3	41	9	50	1484.02
#16	RHOXF2B	41	6	47	1624.22
#17	NR3C1	40	6	46	1424.842
#18	ZIC3	40	5	45	2439.235
#19	ZBTB38	40	11	51	1701.971
#20	EVX1	39	7	46	1421.803
#21	TBX21	39	5	44	1454.697
#22	ARNT2	39	6	45	429.669
#23	IRF6	39	3	42	411.419
#24	ZNF167	38	12	50	2017.448
#25	ELF3	38	5	43	686.534
#26	MEIS1	38	11	49	1611.624
#27	SPDEF	36	8	44	914.674
#28	FOXQ1	36	4	40	232.116
#29	TCF21	36	6	42	1683.837
#30	EMX1	36	8	44	1043.816
#31	GRHL2	35	8	43	896.176
#32	GTF2I	35	6	41	531.348
#33	KLF3	35	6	41	407.719
#34	LEF1	34	11	45	1506.03
#35	GATA6	34	10	44	1492.455
#36	VDR	34	8	42	1092.081
#37	HEY2	33	13	46	1304.763
#38	CREB3L4	33	9	42	834.887
#39	RUNX1T1	33	7	40	237.775
#40	CREBL2	33	13	46	2079.384
#41	ZKSCAN1	32	9	41	605.828
#42	FOXN2	32	7	39	864.23
#43	HLF	32	7	39	1023.951
#44	ZIC2	32	9	41	830.498
#45	BTG2	32	12	44	4199.074
#46	JUNB	31	4	35	170.899
#47	TSHZ2	31	3	34	790.764
#48	ESRRG	30	4	34	257.697
#49	NPAS2	30	11	41	3493.137
#50	ZFP36L2	30	8	38	891.231
#51	ZNF189	30	7	37	678.1
#52	ELF4	29	15	44	2088.255
#53	MITF	29	16	45	1604.874
#54	E2F8	29	8	37	269.373
#55	MBD1	28	10	38	1745.449
#56	GATA1	28	10	38	2241.243
#57	FOXN4	27	8	35	1606.291
#58	SATB2	27	9	36	1123.731
#59	BHLHE41	27	16	43	5630.279
#60	STAT4	27	9	36	949.862
#61	UHRF1	27	5	32	179.431
#62	CCRN4L	27	14	41	1153.067
#63	MEF2C	27	4	31	78.284
#64	OVOL1	26	10	36	986.351
#65	PTTG1	26	6	32	382.427
#66	HMX2	26	8	34	844.316
#67	FLI1	26	9	35	960.272
#68	ZIC5	26	5	31	163.33
#69	AR	26	13	39	1706.63
#70	RHOXF2	26	4	30	200.205
#71	MAFB	26	11	37	1019.898
#72	HOXA3	26	14	40	2545.904
#73	ZFPM2	26	8	34	335.823
#74	FOXD1	25	19	44	1493.774
#75	EBF1	25	9	34	1088.025
#76	ETV6	25	14	39	788.083
#77	SIX6	25	6	31	537.194
#78	SOX6	25	8	33	498.136
#79	ERG	25	5	30	160.355
#80	FOXC2	25	2	27	80.301
#81	ETV7	25	14	39	1544.453
#82	BATF	24	15	39	2094.496
#83	FOXD2	24	13	37	1639.239
#84	PAX3	24	10	34	318.842
#85	PITX1	24	17	41	1428.077
#86	FOXA3	24	6	30	516.132
#87	SOX9	24	10	34	1678.244
#88	KLF7	24	15	39	2467.774
#89	ZNF219	24	6	30	143.013
#90	THRB	23	15	38	2536.956
#91	ZEB2	23	5	28	659.16
#92	TCF4	23	6	29	177.785
#93	SNAI2	23	22	45	3452.29
#94	EGR2	23	17	40	2146.192
#95	MNX1	23	7	30	221.499
#96	STAT2	23	15	38	2329.412
#97	HAND2	23	10	33	1474.139
#98	THRA	23	9	32	1987.056
#99	SOX17	23	10	33	1652.394
#100	GATA3	22	10	32	361.553
#101	AHCTF1	22	8	30	1695.903
#102	NR3C2	22	23	45	1805.623
#103	LHX2	22	22	44	3837.523
#104	JUND	22	13	35	1148.065
#105	PFDN1	22	5	27	1900.92
#106	KLF2	22	16	38	1051.95
#107	XBP1	22	19	41	4726.663
#108	ZFHX4	22	8	30	443.989
#109	PPARG	22	11	33	1375.629
#110	GLIS3	22	13	35	923.601
#111	IKZF4	21	9	30	333.383
#112	KLF15	21	13	34	1834.6
#113	ZFPM1	21	4	25	62.898
#114	CBFA2T3	21	12	33	2567.449
#115	RORC	21	19	40	863.979
#116	ZNF256	21	6	27	641.861
#117	DLX3	21	6	27	1138.503
#118	TEF	21	7	28	673.254
#119	AHR	21	11	32	720.688
#120	RB1	21	10	31	1265.365
#121	FOXN3	21	15	36	681.073
#122	RORB	20	12	32	3188.245
#123	HOXB3	20	7	27	920.866
#124	FOSL2	20	16	36	2096.581
#125	DLX2	20	9	29	778.712
#126	JDP2	20	15	35	1626.07
#127	DLX4	20	20	40	1696.319
#128	SP140	20	14	34	2063.308
#129	FOXO1	20	17	37	1143.989
#130	CEBPD	20	12	32	828.363
#131	NPAT	20	19	39	2262.157
#132	PAX4	20	5	25	158.895
#133	NFE2L3	20	13	33	2465.591
#134	CEBPB	20	7	27	555.83
#135	E2F2	20	5	25	120.638
#136	ELK3	20	7	27	1233.149
#137	MXD1	20	17	37	1855.092
#138	IRF2	19	13	32	1509.877
#139	RARA	19	20	39	4139.105
#140	MLL	19	6	25	387.811
#141	HNF1B	19	11	30	749.466
#142	PKNOX2	19	11	30	1550.961
#143	FBXW7	19	13	32	778.893
#144	GCFC1	19	10	29	882.236
#145	MTA3	19	17	36	483.353
#146	E2F7	19	11	30	954.649
#147	ESX1	19	2	21	376.774
#148	TCF7L2	19	14	33	888.955
#149	POU5F1	18	17	35	1670.207
#150	MSX2	18	18	36	1246.426
#151	HOXB6	18	10	28	533.424
#152	SCRT2	18	7	25	196.216
#153	SOX1	18	4	22	46.079
#154	CSRNP3	18	14	32	1163.63
#155	TRIM29	18	18	36	623.67
#156	TFDP2	18	17	35	1618.675
#157	KLF12	18	13	31	743.984
#158	PHOX2A	18	1	19	6.536
#159	BTAF1	18	15	33	1332.859
#160	RBPJL	18	12	30	2072.987
#161	ZNF83	18	16	34	1715.272
#162	ALX1	18	16	34	1193.829
#163	TSC22D1	18	18	36	2847.374
#164	PURA	17	15	32	608.449
#165	NR0B1	17	9	26	386.319
#166	SCRT1	17	8	25	399.763
#167	TMEM229A	17	13	30	3160.399
#168	MYOD1	17	2	19	18.642
#169	C11orf9	17	14	31	349.253
#170	KCNH8	17	24	41	8033.627
#171	FOXA2	17	11	28	624.976
#172	MEIS2	17	13	30	585.606
#173	RAX2	17	8	25	1107.063
#174	SMAD4	17	12	29	2197.385
#175	TFCP2L1	17	17	34	1360.647
#176	NFE2L1	17	8	25	941.133
#177	EOMES	17	12	29	1466.03
#178	TAL1	17	18	35	889.373
#179	NKX2-8	17	6	23	109.833
#180	KLF5	17	14	31	542.257
#181	HOXC13	17	19	36	1063.799
#182	ONECUT2	17	18	35	1056.359
#183	AEBP1	16	13	29	938.066
#184	HNF1A	16	7	23	1736.026
#185	PGR	16	15	31	668.016
#186	ATF4	16	10	26	177.681
#187	GLI2	16	12	28	1844.51
#188	RUNX2	16	19	35	1041.875
#189	TSC22D3	16	14	30	740.743
#190	HMGB2	16	13	29	3332.417
#191	IRF8	16	15	31	1425.381
#192	HOXB2	16	15	31	806.262
#193	NR1I2	16	14	30	487.478
#194	SMAD9	15	10	25	201.248
#195	LZTS1	15	14	29	1958.181
#196	KLF4	15	18	33	2414.596
#197	NFATC2	15	16	31	1654.52
#198	ZNF135	15	7	22	81.51
#199	PRRX1	15	14	29	852.464
#200	FOXG1	15	9	24	379.415
#201	EN2	15	5	20	59.483
#202	POU3F3	15	8	23	135.933
#203	PBX3	15	14	29	713.656
#204	GAS7	15	12	27	1298.667
#205	NFIB	15	22	37	2429.609
#206	ZNF323	14	15	29	1414.211
#207	HOXB7	14	13	27	816.679
#208	USF2	14	9	23	1057.681
#209	RELB	14	10	24	1083.538
#210	E2F1	14	13	27	913.202
#211	HHEX	14	14	28	1060.203
#212	ZNF207	14	8	22	803.893
#213	ZNF500	14	14	28	2468.575
#214	NFE2	14	10	24	1440.37
#215	BATF3	14	17	31	2086.896
#216	ZNF367	14	18	32	1126.404
#217	MECOM	14	15	29	281.408
#218	STAT1	14	13	27	1598.349
#219	ESR1	13	17	30	2617.875
#220	IKZF1	13	13	26	575.931
#221	RFXAP	13	14	27	786.071
#222	ZNF91	13	16	29	989.306
#223	FOSL1	13	15	28	1104.801
#224	POU3F2	13	17	30	910.771
#225	EGR1	13	10	23	697.77
#226	TRPS1	13	14	27	1050.272
#227	IRF4	13	9	22	444.035
#228	FOS	13	6	19	204.255
#229	PROX1	13	8	21	591.244
#230	TWIST1	13	21	34	1597.513
#231	KLF9	13	16	29	1208.19
#232	DLX1	13	15	28	1482.422
#233	RCAN1	13	14	27	2724.481
#234	LHX1	13	11	24	535.177
#235	NPAS1	13	20	33	1536.773
#236	SOX10	12	11	23	2513.776
#237	FOXA1	12	22	34	804.454
#238	TRERF1	12	16	28	2831.929
#239	ENO1	12	21	33	965.036
#240	KLF16	12	7	19	44.418
#241	FOXE1	12	11	23	461.94
#242	NFATC1	12	15	27	512.291
#243	MYC	12	22	34	3356.209
#244	NKX3-2	12	9	21	311.955
#245	PLSCR1	12	14	26	1457.959
#246	ZSCAN10	12	12	24	252.224
#247	ZXDC	12	11	23	1012.969
#248	ZNF24	12	17	29	827.531
#249	SIM2	12	13	25	306.691
#250	E2F5	12	12	24	1622.59
#251	LCOR	12	19	31	1601.145
#252	GLI3	12	15	27	645.451
#253	NOTCH1	12	18	30	1700.675
#254	ZEB1	12	20	32	2092.707
#255	ONECUT1	12	12	24	783.941
#256	NEUROD1	12	10	22	341.274
#257	MEIS3P1	12	20	32	723.585
#258	ZFHX2	12	20	32	1178.889
#259	RXRA	11	17	28	621.463
#260	SIX1	11	16	27	1116.096
#261	NANOG	11	21	32	1176.424
#262	SIX3	11	14	25	2189.287
#263	HCLS1	11	9	20	283.641
#264	ZNF93	11	15	26	241.137
#265	IRX4	11	9	20	342.444
#266	TCF25	11	14	25	606.937
#267	NANOGP1	11	14	25	3148.12
#268	ARNT	11	15	26	1000.361
#269	IRF3	11	14	25	906.625
#270	ZNF33B	11	17	28	1340.988
#271	ZHX3	11	13	24	836.31
#272	SOX18	11	8	19	144.025
#273	CREBZF	11	19	30	1037.873
#274	PRDM1	10	24	34	1773.289
#275	HOXB9	10	22	32	693.968
#276	CSDA	10	17	27	1788.565
#277	BCL3	10	15	25	740.667
#278	MAF	10	21	31	1126.2
#279	MEOX2	10	12	22	145.363
#280	ARX	10	8	18	614.244
#281	PEG3	10	22	32	1421.643
#282	CEBPE	10	19	29	1925.342
#283	SOX5	10	17	27	1647.239
#284	TP63	10	23	33	2488.239
#285	TCFL5	10	15	25	816.399
#286	YEATS4	10	16	26	1400.308
#287	PRRX2	10	19	29	1578.075
#288	NR5A2	10	10	20	1510.59
#289	SRF	10	15	25	713.407
#290	ETS1	10	16	26	832.738
#291	HNF4A	10	11	21	751.172
#292	MAFA	10	11	21	1887.818
#293	ZFP36L1	10	15	25	787.157
#294	NR1H3	10	21	31	1687.333
#295	HMGA2	10	19	29	1146.479
#296	C5orf41	10	12	22	446.471
#297	EGR3	10	11	21	1579.894
#298	FOXF2	10	13	23	1180.803
#299	MMP14	10	23	33	1097.539
#300	NKX2-3	10	16	26	423.406
#301	TFAM	9	24	33	816.205
#302	KLF10	9	19	28	682.462
#303	BLZF1	9	11	20	439.439
#304	TP73	9	8	17	74.564
#305	HOXA4	9	17	26	527.079
#306	FOXP2	9	18	27	2058.516
#307	CSRNP1	9	17	26	1083.783
#308	TFAP2A	9	13	22	4761.464
#309	SOX7	9	18	27	1199.952
#310	HOXA13	9	17	26	550.517
#311	HOXD8	9	23	32	1645.451
#312	TCF19	9	14	23	649.051
#313	TCF7	9	13	22	1009.658
#314	ST18	9	20	29	2226.641
#315	ZSCAN16	9	17	26	798.631
#316	HOXC8	9	24	33	2246.287
#317	TWIST2	9	17	26	1243.953
#318	TFAP2C	9	26	35	1832.235
#319	CTNNB1	9	20	29	612.275
#320	NFIX	9	15	24	862.216
#321	AFF4	9	19	28	4602.472
#322	SOX11	9	19	28	672.7
#323	HOXB8	9	17	26	1886.856
#324	IRX5	9	13	22	1766.694
#325	REL	8	14	22	1088.023
#326	CUX2	8	19	27	478.939
#327	JUN	8	14	22	438.382
#328	TBX2	8	21	29	1121.16
#329	MESP1	8	25	33	1327.994
#330	FOXL2	8	16	24	666.224
#331	ERF	8	21	29	1038.706
#332	NR1H4	8	13	21	228.348
#333	RCOR2	8	9	17	82.053
#334	ETS2	8	21	29	1060.619
#335	ZSCAN4	8	17	25	1023.513
#336	NR2F2	8	16	24	298.522
#337	ATF3	8	9	17	709.106
#338	ZNF217	8	19	27	1490.443
#339	HOXC9	8	17	25	494.233
#340	VTN	8	17	25	1329.855
#341	NR2F1	8	17	25	478.742
#342	HOXD1	8	16	24	968.457
#343	ZNF71	8	17	25	296.316
#344	LHX6	8	13	21	891.32
#345	TFAP2B	8	16	24	1747.587
#346	HEY1	8	18	26	787.3
#347	BCL11B	8	18	26	416.497
#348	ZNF138	8	12	20	233.508
#349	PHTF1	8	17	25	1017.781
#350	ZNF397	7	21	28	831.551
#351	TBX15	7	21	28	592.946
#352	SPIB	7	18	25	593.071
#353	IRF1	7	17	24	1466.109
#354	GABPB1	7	24	31	1467.975
#355	YBX1	7	21	28	3831.091
#356	NEUROG1	7	10	17	810.718
#357	CTBP1	7	19	26	762.214
#358	SLC26A3	7	11	18	1059.233
#359	NR4A1	7	10	17	1266.333
#360	CDX2	7	13	20	1836.802
#361	MEOX1	7	20	27	568.665
#362	MGA	7	16	23	558.755
#363	WNT5A	7	24	31	1017.456
#364	HES1	7	14	21	480.655
#365	HOPX	7	21	28	875.716
#366	ZIC1	7	18	25	2202.216
#367	ETV5	7	15	22	634.258
#368	GRHL3	7	19	26	1573.012
#369	LASS6	7	20	27	1069.754
#370	MLXIPL	7	21	28	946.331
#371	DMTF1	7	26	33	2763.489
#372	CNBP	7	12	19	1029.093
#373	SOX4	7	25	32	1801.555
#374	HNF4G	6	17	23	1496.134
#375	TBX3	6	22	28	1109.671
#376	FOXF1	6	18	24	568.276
#377	TCF15	6	18	24	408.276
#378	NFYA	6	16	22	356.702
#379	HOXB5	6	17	23	729.943
#380	NFIC	6	18	24	261.613
#381	TCF7L1	6	22	28	559.686
#382	RUNX3	6	14	20	909.885
#383	HOXC10	6	17	23	2114.995
#384	SCAND3	6	25	31	1029.608
#385	HOXA5	6	14	20	559.846
#386	VENTX	6	19	25	1139.689
#387	TFEC	6	23	29	1758.133
#388	ARNTL	6	17	23	466.295
#389	GATA4	6	21	27	1888.427
#390	SOX2	6	22	28	1141.254
#391	EGR4	6	25	31	2339.861
#392	HOXB4	6	18	24	2627.368
#393	BACH1	6	16	22	509.338
#394	ISX	6	19	25	3730.869
#395	REST	6	15	21	286.021
#396	HESX1	6	19	25	383.595
#397	MEF2A	6	13	19	535.626
#398	ZNF85	6	19	25	982.761
#399	KLF6	6	18	24	1125.626
#400	WT1	6	17	23	326.74
#401	EN1	5	18	23	1548.364
#402	HES5	5	17	22	681.682
#403	SIX4	5	20	25	501.94
#404	SCML2	5	20	25	2698.8
#405	ZFP42	5	11	16	95.484
#406	BNC1	5	14	19	383.99
#407	SREBF1	5	23	28	2127.073
#408	ZNF92	5	20	25	1141.678
#409	CREBBP	5	18	23	832.709
#410	SPEN	5	23	28	1637.599
#411	SCML1	5	13	18	288.569
#412	ISL1	5	17	22	1127.317
#413	MAFK	5	18	23	313.361
#414	MYNN	5	16	21	1346.122
#415	NR2F6	5	16	21	247.856
#416	SMAD3	5	28	33	518.034
#417	CEBPA	5	22	27	635.595
#418	SOLH	5	20	25	454.215
#419	DMRT2	5	20	25	520.713
#420	PITX2	5	25	30	663.852
#421	NR4A2	5	12	17	323.266
#422	TRIM28	5	13	18	653.236
#423	STAT6	5	19	24	231.945
#424	SOX30	4	17	21	1660.966
#425	POU3F1	4	16	20	527.837
#426	GATA5	4	20	24	2740.099
#427	RUNX1	4	22	26	552.435
#428	L3MBTL4	4	17	21	334.841
#429	LMO4	4	18	22	534.656
#430	CREM	4	15	19	193.823
#431	HOXA10	4	16	20	362.616
#432	PAX6	4	14	18	440.411
#433	BATF2	4	17	21	180.513
#434	VAV1	4	22	26	2075.609
#435	GTF2IRD1	4	16	20	151.631
#436	GBX1	4	11	15	320.755
#437	FOXC1	4	25	29	1364.195
#438	PLAG1	4	21	25	825.701
#439	FOSB	4	17	21	469.092
#440	PDX1	4	19	23	1947.723
#441	DDIT3	4	14	18	453.692
#442	IRX2	4	18	22	580.597
#443	MYCN	4	21	25	357.41
#444	ZNF165	4	18	22	440.124
#445	FUBP1	4	11	15	385.153
#446	ETV1	4	19	23	263.081
#447	SOX21	3	21	24	157.675
#448	FOXM1	3	16	19	412.357
#449	IRF7	3	21	24	525.412
#450	SATB1	3	26	29	972.161
#451	SALL1	3	20	23	270.891
#452	MKX	3	17	20	147.102
#453	ZNF449	3	22	25	828.731
#454	TBX1	3	23	26	1005.1
#455	HOXB13	3	17	20	171.314
#456	PBX4	3	26	29	1552.182
#457	GSC	3	20	23	755.334
#458	HIRA	3	18	21	624.356
#459	BARX1	3	18	21	854.057
#460	RARB	3	18	21	144.917
#461	HOXA9	3	17	20	1290.153
#462	ZNF215	3	22	25	150.394
#463	PBX2	3	17	20	296.516
#464	NR1D2	3	17	20	90.654
#465	BCL6	3	17	20	117.736
#466	ELF5	3	23	26	1564.83
#467	NR1D1	3	20	23	711.776
#468	HOXA11	3	20	23	1757.466
#469	TBX22	3	16	19	127.159
#470	TAF13	3	13	16	100.845
#471	RORA	3	23	26	837.247
#472	USF1	2	24	26	3359.457
#473	ATF7	2	23	25	568.521
#474	HIF1A	2	18	20	214.704
#475	ASCL2	2	20	22	363.725
#476	CREB3L3	2	20	22	663.842
#477	PPARA	2	22	24	444.021
#478	ZNF175	2	15	17	340.747
#479	HOXA2	2	17	19	571.642
#480	NFIL3	2	18	20	180.506
#481	HOXA7	2	25	27	442.389
#482	HOXC12	2	17	19	435.476
#483	FOXJ1	2	20	22	535.821
#484	POU1F1	2	23	25	150.041
#485	CREB5	1	26	27	266.936
#486	CDKN2A	1	25	26	121.668
#487	IRX3	1	24	25	124.928
#488	NKX2-1	1	19	20	60.152
#489	TAF5L	1	20	21	59.901
#490	ANKRD30A	1	14	15	33.254
#491	POU2F3	1	17	18	232.527
#492	SOX8	1	23	24	49.015
#493	AFF1	1	25	26	61.542
#494	NKX6-2	0	23	23	0
#495	HIF3A	0	27	27	0
#496	IRF5	0	26	26	0
#497	TBR1	0	18	18	0
#498	HMBOX1	0	25	25	0
#499	C12orf28	0	17	17	0
#500	PAX8	0	21	21	0