Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	TFAP2D	42	8	50	974.698
#2	ELK3	37	3	40	265.543
#3	IRF7	36	7	43	369.696
#4	SATB1	36	6	42	451.444
#5	FOSL2	34	5	39	1539.897
#6	PAX5	32	6	38	894.379
#7	HMGB1	32	9	41	3366.153
#8	MYNN	31	2	33	65.517
#9	PRRX1	31	3	34	778.897
#10	STAT2	30	6	36	374.022
#11	SRY	29	1	30	1348.075
#12	HMX2	29	5	34	371.731
#13	SPI1	28	5	33	6178.279
#14	HSFY1	28	8	36	518.646
#15	ESRRB	28	2	30	98.07
#16	POU1F1	27	1	28	11.256
#17	ELF2	27	5	32	374.413
#18	ARGFX	27	6	33	167.703
#19	TLX2	26	9	35	3738.405
#20	ASCL2	26	6	32	317.318
#21	GLIS2	26	3	29	42.158
#22	MAFB	26	6	32	2288.751
#23	LHX3	26	11	37	1479.884
#24	STRN3	25	14	39	5939.694
#25	ZNF192	25	2	27	35.355
#26	HOXA6	25	6	31	1185.625
#27	GATA1	25	6	31	178.798
#28	NCOR1	24	7	31	621.09
#29	EBF1	24	6	30	265.586
#30	HIF3A	24	6	30	275.026
#31	BTAF1	23	7	30	841.647
#32	HOXD10	23	7	30	905.553
#33	HDAC1	23	9	32	12610.478
#34	TWIST1	23	8	31	3949.325
#35	RAX2	23	5	28	9555.929
#36	ELF3	23	9	32	3972.866
#37	BRD8	23	4	27	225.562
#38	PCGF2	23	1	24	92.053
#39	ATF7	22	9	31	353.479
#40	FOXK1	22	2	24	115.171
#41	HNF1A	22	7	29	3821.015
#42	NR2E3	21	7	28	3793.262
#43	FOXO4	21	7	28	788.93
#44	ZNF24	21	5	26	213.656
#45	ATF4	21	7	28	609.818
#46	EMX1	21	4	25	1113.245
#47	FOXO1	21	5	26	942.828
#48	STAT5B	21	8	29	9542.166
#49	GATA2	20	5	25	189.318
#50	ZNF449	20	10	30	5633.544
#51	TLX1	20	7	27	2234.631
#52	ISX	20	7	27	376.942
#53	ESR1	20	6	26	17730.086
#54	LHX9	20	6	26	6200.81
#55	NFIL3	20	11	31	2040.7
#56	ZNF287	20	9	29	4784.258
#57	HOXC12	20	7	27	12231.217
#58	PBX1	20	7	27	273.539
#59	MEOX1	20	12	32	27647.864
#60	POU2F1	20	8	28	335.374
#61	HOXD13	20	7	27	2309.37
#62	FOXD4L2	20	4	24	201.419
#63	ERG	19	8	27	598.81
#64	ELF1	19	7	26	2636.647
#65	HMX3	19	6	25	1153.016
#66	ZHX2	19	10	29	869.568
#67	TGIF2LX	19	7	26	1436.455
#68	FOXG1	19	2	21	215.227
#69	FOXR1	19	4	23	764.522
#70	RERE	19	12	31	2342.285
#71	RORB	18	5	23	634.332
#72	TCF12	18	9	27	641.145
#73	TRPS1	18	11	29	1687.188
#74	NFE2L1	18	9	27	511.741
#75	PRDM1	18	13	31	2805.708
#76	RFXAP	18	11	29	2241.075
#77	TBR1	18	6	24	5783.824
#78	RBPJ	18	6	24	1238.283
#79	MMP14	18	11	29	1830.638
#80	TP63	18	5	23	660.516
#81	ZBTB38	17	10	27	1650.27
#82	IRX4	17	9	26	3656.082
#83	YY1	17	10	27	2350.228
#84	NPAS2	17	16	33	1390.198
#85	CUX2	17	9	26	417.735
#86	ZBTB17	17	11	28	4748.704
#87	NKX6-2	16	8	24	376.024
#88	NEUROD2	16	8	24	24500.312
#89	TGIF1	16	11	27	1501.047
#90	ZNF140	16	6	22	325.424
#91	GSX2	16	11	27	407.134
#92	AR	16	10	26	1939.812
#93	HNF4A	16	8	24	1509.88
#94	PHOX2A	16	11	27	740.15
#95	THRA	16	7	23	821.18
#96	ZNF274	16	9	25	11330.391
#97	ZNF131	16	8	24	11147.452
#98	RBPJL	16	5	21	123.624
#99	LASS6	16	6	22	525.17
#100	ZSCAN1	16	10	26	1005.926
#101	ARX	15	5	20	204.787
#102	PPARA	15	7	22	289.976
#103	ZNF445	15	6	21	210.659
#104	SNAI2	15	10	25	4793.471
#105	ADNP	15	7	22	1434.192
#106	LASS5	15	6	21	970.287
#107	MBD1	15	11	26	1093.869
#108	TAF12	15	4	19	129.757
#109	TAF6	15	9	24	562.972
#110	TBX19	15	8	23	362.335
#111	ZNF81	15	8	23	459.905
#112	IRF1	15	5	20	834.676
#113	SOX30	15	11	26	2284.541
#114	TCF4	15	10	25	1019.111
#115	DBX1	15	8	23	26653.591
#116	IRF4	15	8	23	592.615
#117	RORA	15	13	28	4693.302
#118	NFE2L2	15	8	23	1272.357
#119	REL	15	8	23	4202.247
#120	TFEC	14	8	22	106.98
#121	HNF4G	14	12	26	2475.218
#122	TBX5	14	9	23	659.246
#123	ZNF281	14	5	19	1982.662
#124	STAT6	14	12	26	5068.181
#125	SP3	14	5	19	156.54
#126	ETS2	14	14	28	2141.533
#127	DLX6	14	15	29	8377.424
#128	GLI3	14	8	22	1361.206
#129	SOX15	14	9	23	17843.364
#130	POU5F1	14	12	26	1836.194
#131	KLF17	14	13	27	20678.376
#132	CNOT7	14	13	27	4474.94
#133	ARID4A	14	8	22	732.352
#134	KLF9	14	11	25	2075.424
#135	ZC3H8	14	11	25	1451.188
#136	OTX1	13	10	23	1781.229
#137	ESRRA	13	12	25	1827.93
#138	EGR1	13	3	16	351.897
#139	ONECUT2	13	11	24	1023.372
#140	TEAD1	13	8	21	387.142
#141	TLX3	13	10	23	3123.69
#142	ZNF41	13	14	27	6220.278
#143	HIC1	13	5	18	245.013
#144	TSHZ2	13	11	24	1828.038
#145	JDP2	13	10	23	631.924
#146	ZNF69	13	10	23	1831.578
#147	NKX2-5	13	7	20	2699.143
#148	PLSCR1	13	11	24	2352.587
#149	C1orf85	13	6	19	179.163
#150	LHX2	13	12	25	3348.517
#151	PPARG	13	8	21	2480.948
#152	FOXD4L3	12	10	22	432.071
#153	HCFC1	12	7	19	1556.882
#154	ELF4	12	10	22	2639.474
#155	MYF6	12	9	21	490.422
#156	TCF7L2	12	11	23	2620.053
#157	BLZF1	12	11	23	2592.708
#158	FOXF1	12	11	23	2466.299
#159	FOXN3	12	10	22	2805.607
#160	SMAD5	12	12	24	2339.538
#161	ZIC3	12	8	20	465.018
#162	HOXD11	12	7	19	2647.155
#163	SHOX	12	9	21	174.508
#164	HIF1A	12	10	22	1493.225
#165	SOX18	12	10	22	1374.167
#166	ZSCAN18	12	7	19	1680.312
#167	MKX	12	13	25	1990.485
#168	HNF1B	12	11	23	4265.081
#169	BCL3	12	7	19	418.296
#170	RELB	12	7	19	780.55
#171	ZNF93	12	7	19	96.36
#172	FOXA2	12	11	23	1489.376
#173	PURB	12	10	22	4353.366
#174	ZNF213	12	7	19	3077.6
#175	SMAD4	12	9	21	10331.648
#176	NFIB	11	11	22	1528.571
#177	PAX3	11	9	20	559.107
#178	HOXA1	11	9	20	135.737
#179	ZFHX3	11	14	25	652.206
#180	NFATC3	11	8	19	181.162
#181	SIX5	11	8	19	459.474
#182	ARNT	11	10	21	241.378
#183	POU6F1	11	7	18	154.798
#184	HOXD12	11	9	20	16951.785
#185	KLF1	11	7	18	505.168
#186	NR6A1	11	13	24	852.487
#187	ONECUT3	11	4	15	69.974
#188	TAF5L	11	12	23	1130.225
#189	CDX2	11	6	17	314.757
#190	CEBPD	11	11	22	5123.64
#191	PURA	11	15	26	1462.738
#192	AHR	11	10	21	2077.523
#193	SPIB	10	4	14	38.551
#194	MLLT10	10	4	14	63.616
#195	GATA6	10	11	21	2224.977
#196	FOXP1	10	8	18	1142.483
#197	LEF1	10	4	14	33.38
#198	ZFHX4	10	10	20	866.837
#199	CREB3L1	10	12	22	1008.056
#200	C11orf9	10	10	20	1018.533
#201	ZXDC	10	10	20	815.633
#202	KLF6	10	15	25	1004.427
#203	DMRT2	10	11	21	342.313
#204	MYF5	10	12	22	1633.846
#205	FLI1	10	9	19	915.471
#206	MEIS1	10	11	21	12173.684
#207	MTA2	10	11	21	875.754
#208	ZNF277	10	12	22	2856.929
#209	CREB1	10	12	22	1369.833
#210	POU4F2	10	9	19	9965.353
#211	NFIA	10	13	23	1258.061
#212	ZNF189	10	14	24	1735.17
#213	VENTX	10	9	19	2851.092
#214	TSHZ3	10	13	23	1195.729
#215	JUNB	10	9	19	1092.554
#216	MLXIPL	10	9	19	291.597
#217	TBP	10	10	20	1460.878
#218	POU2F2	10	12	22	3977.118
#219	LASS2	9	9	18	3106.391
#220	RARB	9	11	20	1939.756
#221	EPAS1	9	7	16	372.939
#222	MSX1	9	10	19	2828.55
#223	FOSL1	9	11	20	29361.143
#224	PTH	9	7	16	2231.956
#225	NFYC	9	11	20	2235.106
#226	MTF1	9	11	20	3670.598
#227	MEOX2	9	19	28	6142.692
#228	MNT	9	7	16	152.832
#229	CREBBP	9	10	19	809.535
#230	EVX1	9	10	19	267.25
#231	ZNF438	9	13	22	5252.141
#232	NANOG	9	5	14	1414.009
#233	HMBOX1	9	8	17	2274.673
#234	ZNF207	9	6	15	160.167
#235	HOXD3	9	15	24	1719.366
#236	EGR2	9	12	21	4985.343
#237	SP4	9	13	22	2556.884
#238	ZEB2	9	13	22	2667.305
#239	HSF2	9	11	20	1093.58
#240	ZXDA	9	9	18	884.437
#241	TULP4	9	9	18	508.63
#242	ARNTL	9	12	21	1041.616
#243	TSC22D1	9	11	20	1115.018
#244	PLAG1	8	8	16	193.323
#245	GATA4	8	12	20	1822.574
#246	ELK1	8	8	16	155.179
#247	NKX1-2	8	6	14	981.521
#248	GTF2H2	8	10	18	1028.595
#249	TFAP2A	8	10	18	2155.061
#250	TCEAL1	8	9	17	1998.955
#251	BNC1	8	11	19	2824.819
#252	NR1D2	8	9	17	856.681
#253	LCOR	8	9	17	2137.943
#254	GRHL2	8	12	20	2345.872
#255	STAT1	8	7	15	706.738
#256	RFX3	8	10	18	892.006
#257	ZNF643	8	15	23	1903.107
#258	RHOXF2	8	9	17	198.19
#259	TFE3	8	6	14	807.052
#260	KLF10	8	10	18	999.928
#261	MITF	8	10	18	297.933
#262	XBP1	8	9	17	1062.476
#263	STAT3	8	8	16	703.592
#264	VSX2	8	5	13	87.735
#265	OTX2	8	7	15	1205.532
#266	FOXQ1	8	5	13	605.203
#267	BTG2	8	14	22	4008.512
#268	NFXL1	8	9	17	2125.552
#269	SOX11	8	9	17	2119.209
#270	SIN3A	8	10	18	172.435
#271	HSF4	8	6	14	586.243
#272	YBX1	8	6	14	529.908
#273	TBX21	7	14	21	3370.256
#274	MAX	7	7	14	1708.464
#275	PBX4	7	10	17	5611.853
#276	YEATS4	7	3	10	86.202
#277	MXD1	7	8	15	1395.586
#278	TCF15	7	10	17	20220.951
#279	TBX1	7	5	12	95.773
#280	AEBP1	7	12	19	441.19
#281	MEF2D	7	10	17	631.003
#282	SOX7	7	12	19	484.096
#283	IRF6	7	11	18	1295.018
#284	SREBF1	7	11	18	686.172
#285	DLX2	7	15	22	3809.985
#286	JUN	7	13	20	1781.096
#287	HOXB1	7	10	17	2387.52
#288	RCAN1	7	9	16	2682.779
#289	CUX1	7	8	15	243.353
#290	NR1I2	7	14	21	1060.793
#291	SIX2	7	6	13	955.924
#292	NR3C1	7	13	20	2829.639
#293	ZNF133	7	8	15	102.125
#294	RUNX2	7	14	21	1198.06
#295	TRIM22	7	13	20	1195.318
#296	NR2F2	7	10	17	934.936
#297	ATF6	7	6	13	7345.284
#298	ZNF148	7	10	17	2892.772
#299	FOXE1	7	10	17	532.205
#300	E2F3	7	12	19	358.558
#301	PLAGL2	7	17	24	899.902
#302	SALL1	7	11	18	2634.706
#303	GTF2I	7	15	22	402.394
#304	HDAC2	7	10	17	4065.907
#305	LZTS1	6	12	18	1152.051
#306	SMAD6	6	18	24	4326.941
#307	TRERF1	6	7	13	759.873
#308	MEIS3P1	6	12	18	373.797
#309	CLOCK	6	10	16	1991.361
#310	NR4A1	6	7	13	246.92
#311	SNAPC4	6	9	15	396.021
#312	ZNF117	6	8	14	2097.791
#313	NR1H4	6	11	17	6500.791
#314	HMX1	6	8	14	3851.32
#315	VDR	6	15	21	571.915
#316	ZNF215	6	10	16	828.522
#317	HOXA11	6	8	14	1211.395
#318	HEYL	6	14	20	2920.086
#319	BACH1	6	10	16	410.757
#320	RUNX1T1	6	14	20	3149.793
#321	EN2	6	10	16	10740.577
#322	AFF4	6	7	13	861.71
#323	ZNF70	6	12	18	920.525
#324	HOXC6	6	14	20	379.781
#325	NFATC2	6	14	20	986.328
#326	TAF1B	6	12	18	259.367
#327	BATF2	6	15	21	2236.909
#328	NR4A2	6	11	17	381.875
#329	NKX2-1	6	10	16	2278.282
#330	MGA	6	13	19	1844.831
#331	HOXC11	6	12	18	441.736
#332	POU2F3	6	11	17	1406.792
#333	ALX1	6	12	18	1201.568
#334	HEY2	6	10	16	1183.797
#335	NRL	6	10	16	630.842
#336	SNAPC5	6	6	12	105.875
#337	MAFF	6	9	15	238.56
#338	IRX3	5	8	13	323.469
#339	ZBTB25	5	11	16	618.101
#340	GTF2IRD1	5	10	15	273.925
#341	NANOGP8	5	5	10	460.022
#342	CITED1	5	14	19	355.824
#343	MSC	5	11	16	587.736
#344	SIX4	5	16	21	5797.026
#345	IRX2	5	11	16	341.082
#346	ZNF323	5	7	12	139.318
#347	DLX1	5	14	19	7524.612
#348	SMAD1	5	13	18	2048.857
#349	PPARD	5	7	12	128.66
#350	NR2F1	5	13	18	1706.987
#351	ZNF187	5	11	16	1025.741
#352	FOXA1	5	10	15	204.318
#353	TCF7L1	5	14	19	510.583
#354	NFATC1	5	13	18	1036.947
#355	BCL6	5	13	18	2352.707
#356	SIM2	5	19	24	822.587
#357	EHF	5	14	19	861.636
#358	PAX6	5	8	13	357.212
#359	ZNF165	5	14	19	3261.858
#360	NOTCH1	5	10	15	142.919
#361	MAF	5	9	14	55.938
#362	CREB3L2	5	7	12	819.284
#363	SP1	5	10	15	1186.082
#364	ZNF83	5	13	18	635.962
#365	NR4A3	5	9	14	191.185
#366	NFX1	5	12	17	1603.263
#367	GSC	5	9	14	947.085
#368	HOPX	4	13	17	913.329
#369	HES6	4	13	17	224.496
#370	ADNP2	4	15	19	1872.487
#371	HOXA10	4	13	17	1510.123
#372	ETV7	4	8	12	235.851
#373	ST18	4	13	17	9898.873
#374	IRF2	4	10	14	4411.001
#375	HOXB5	4	12	16	306.839
#376	ZNF496	4	9	13	172.481
#377	HOXA3	4	11	15	635.894
#378	ZNF236	4	12	16	2777.325
#379	STAT4	4	12	16	252.848
#380	GLI2	4	12	16	388.386
#381	HOXB2	4	12	16	3454.287
#382	ARID3A	4	12	16	1834.142
#383	HOXC8	4	12	16	1878.451
#384	ZHX3	4	12	16	646.188
#385	NFIC	4	13	17	2768.769
#386	PKNOX2	4	16	20	531.025
#387	NKX2-8	4	13	17	2209.392
#388	ZNF92	4	12	16	230.251
#389	ZNF135	4	12	16	1275.426
#390	GATAD1	4	10	14	1431.378
#391	SPIC	4	16	20	4219.368
#392	KLF3	4	15	19	458.799
#393	HOXA7	4	12	16	597.357
#394	TFCP2L1	4	12	16	915.958
#395	HOXC5	4	9	13	430.543
#396	MSRB2	4	9	13	111.547
#397	CREBL2	4	12	16	795.766
#398	EVI1	4	12	16	4087.679
#399	NFE2L3	4	13	17	507.62
#400	ZSCAN16	4	12	16	1594.13
#401	AHCTF1	4	8	12	92.959
#402	HOXB6	4	7	11	352.38
#403	ZIC1	4	14	18	680.422
#404	PRRX2	4	15	19	1692.213
#405	FOS	3	12	15	296.423
#406	KLF15	3	14	17	568.412
#407	GATA3	3	13	16	834.781
#408	MYT1L	3	13	16	319.205
#409	KLF12	3	16	19	321.824
#410	MEIS2	3	15	18	2824.549
#411	MEF2A	3	12	15	1750.687
#412	ZSCAN21	3	11	14	407.54
#413	ARNTL2	3	19	22	1403.334
#414	ATF3	3	11	14	2195.65
#415	GTF2H3	3	11	14	179.92
#416	RORC	3	13	16	171.333
#417	ELF5	3	11	14	742.077
#418	HIRA	3	10	13	268.058
#419	NFAT5	3	13	16	296.723
#420	SMAD3	3	11	14	412.323
#421	CREB5	3	13	16	5973.438
#422	ELK4	3	8	11	163.069
#423	PROX1	3	12	15	1122.322
#424	THRB	3	19	22	2404.443
#425	HOXA13	3	11	14	999.212
#426	E2F5	3	11	14	577.398
#427	MYC	3	15	18	427.653
#428	PBX3	3	17	20	411.698
#429	FOXP4	3	8	11	51.611
#430	SCML1	3	12	15	525.064
#431	ISL1	3	14	17	1134.8
#432	ATF1	3	11	14	432.602
#433	RUNX3	3	14	17	1471.94
#434	E2F8	3	16	19	2193.397
#435	HOXC13	3	16	19	1231.437
#436	ARNT2	3	14	17	1169.281
#437	IKZF1	3	8	11	1181.577
#438	ZFP42	3	15	18	19228.293
#439	RXRA	3	7	10	183.195
#440	ATF2	2	14	16	460.864
#441	NR2E1	2	15	17	1846.376
#442	TBX15	2	10	12	258.647
#443	MYCN	2	10	12	3167.211
#444	WNT5A	2	8	10	77.042
#445	MTA3	2	8	10	142.935
#446	BATF	2	12	14	313.737
#447	OVOL1	2	17	19	518.229
#448	PHTF1	2	14	16	241.784
#449	HESX1	2	16	18	3704.662
#450	NR3C2	2	18	20	2201.29
#451	GRHL3	2	4	6	58.612
#452	TAF4B	2	12	14	780.605
#453	ZSCAN2	2	11	13	781.46
#454	SIX1	2	14	16	978.597
#455	ZNF232	2	16	18	1447.117
#456	ZNF483	2	12	14	2407.884
#457	HOXD4	2	12	14	461.799
#458	HOXD1	2	14	16	461.799
#459	PITX2	2	13	15	609.158
#460	SLC26A3	2	16	18	505.672
#461	NME2	2	8	10	16.868
#462	SOX2	2	13	15	1710.629
#463	ZBTB48	2	7	9	17.28
#464	RUNX1	2	17	19	718.629
#465	PHOX2B	2	12	14	19.209
#466	ESRRG	2	17	19	1385.363
#467	BATF3	2	13	15	365.593
#468	HOXB13	2	20	22	605.429
#469	TCFL5	2	12	14	979.914
#470	PAX4	1	10	11	670.902
#471	SOX1	1	11	12	659.741
#472	DMRT1	1	15	16	60.683
#473	ZNF397	1	8	9	43.922
#474	MSX2	1	15	16	71.378
#475	RCOR2	1	13	14	687.701
#476	NPAT	1	8	9	99.955
#477	WT1	1	8	9	230.843
#478	ZNF169	1	9	10	74.338
#479	HOXC10	1	17	18	117.274
#480	NR5A2	1	8	9	43.093
#481	ZNF394	1	8	9	36.635
#482	HOXA9	1	14	15	2049.488
#483	CBFA2T3	1	15	16	560.947
#484	FBXW7	1	15	16	171.888
#485	NKX3-2	1	12	13	892.26
#486	SIX6	1	10	11	66.073
#487	DMTF1	1	14	15	749.685
#488	MAFG	1	11	12	61.17
#489	HMGA2	1	11	12	1125.373
#490	ZNF498	1	8	9	6.556
#491	TFDP2	1	13	14	584.959
#492	KCNH8	1	10	11	6815.052
#493	FOXC1	1	14	15	118.588
#494	MESP1	0	13	13	0
#495	SMAD9	0	16	16	0
#496	ZNF37A	0	12	12	0
#497	LMO4	0	17	17	0
#498	LHX1	0	8	8	0
#499	MYCL1	0	10	10	0
#500	TCF21	0	12	12	0