Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	TCF21	73	2	75	38.326
#2	MYBL2	71	2	73	202.828
#3	FOXM1	64	3	67	42.382
#4	ZEB2	63	5	68	557.85
#5	UHRF1	61	2	63	869.575
#6	FLI1	60	7	67	2181.218
#7	LASS6	60	13	73	1132.946
#8	PTTG1	59	8	67	6158.573
#9	KLF6	57	7	64	620.224
#10	DLX6	56	8	64	715.898
#11	PITX1	54	6	60	250.085
#12	FOXE1	53	7	60	399.224
#13	TFAP2A	51	8	59	322.168
#14	ZC3H8	51	14	65	4497.699
#15	E2F8	48	11	59	1139.913
#16	TP63	47	5	52	727.87
#17	E2F2	46	10	56	425.047
#18	GATA6	45	13	58	1654.595
#19	CSRNP1	44	5	49	333.284
#20	ADNP	44	9	53	2025.874
#21	KLF2	43	6	49	649.066
#22	FOXF1	43	6	49	2488.088
#23	MEF2C	42	6	48	1150.775
#24	TRIM22	42	11	53	4986.058
#25	E2F7	42	7	49	458.861
#26	GRHL3	40	7	47	228.574
#27	FOXP1	40	12	52	868.421
#28	KDM5B	40	6	46	565.361
#29	CITED2	39	9	48	1460.1
#30	TFDP2	39	17	56	1282.26
#31	ERG	37	10	47	6375.049
#32	MTA3	37	10	47	1037.128
#33	ENO1	37	6	43	451.61
#34	HMGA2	37	11	48	2478.84
#35	TRIM29	36	5	41	393.388
#36	NKX2-1	35	14	49	837.88
#37	RUNX1T1	35	8	43	832.308
#38	SOX2	35	16	51	2135.81
#39	ZIC2	34	20	54	2412.594
#40	IRF6	33	10	43	362.129
#41	TCF19	33	11	44	1687.867
#42	KLF5	32	11	43	9608.707
#43	NFIA	32	9	41	892.601
#44	GTF2I	32	4	36	728.391
#45	TBX5	31	5	36	81.117
#46	MITF	31	13	44	705.505
#47	MMP14	31	15	46	536.962
#48	NR2F1	31	10	41	3739.322
#49	ETS2	30	13	43	3621.398
#50	ARNTL2	30	16	46	1632.217
#51	C5orf41	30	10	40	1858.589
#52	ZEB1	29	7	36	509.025
#53	SPDEF	29	13	42	9775.311
#54	RARA	29	14	43	2586.337
#55	HOPX	29	15	44	4058.838
#56	CREBL2	28	10	38	1842.052
#57	HSF2	28	7	35	2438.486
#58	NFE2L1	27	14	41	3416.68
#59	HMGA1	27	12	39	706.077
#60	HOXA1	27	14	41	280.663
#61	JUNB	27	10	37	1049.764
#62	HOXA10	27	12	39	6841.5
#63	MEIS3P1	26	15	41	8707.814
#64	HOXD13	26	12	38	2359.475
#65	SIX2	26	16	42	5748.197
#66	NR3C2	26	15	41	715.413
#67	TCEAL1	26	9	35	234.078
#68	MAFF	25	8	33	570.951
#69	TAL1	25	9	34	241.707
#70	HDAC1	25	12	37	609.898
#71	SOX17	25	9	34	1395.794
#72	HOXB7	25	20	45	4571.862
#73	TFEC	24	7	31	226.475
#74	SOX15	24	12	36	507.529
#75	TBX2	24	11	35	224.301
#76	ZNF367	24	11	35	461.788
#77	SOX12	24	16	40	984.776
#78	OVOL1	23	10	33	252.756
#79	BARX1	23	15	38	6980.077
#80	DLX1	23	12	35	2440.206
#81	TWIST1	23	20	43	2060.782
#82	GATA2	23	12	35	577.836
#83	PPARA	23	12	35	1055.237
#84	FOXA2	23	11	34	695.27
#85	CBFB	23	6	29	728.082
#86	NFKB1	22	8	30	1570.755
#87	FOSB	22	5	27	40.361
#88	IRF1	22	16	38	8281.872
#89	CSDA	21	17	38	1349.909
#90	HDAC2	21	16	37	1923.201
#91	GLI3	21	15	36	2202.703
#92	TSHZ3	21	16	37	4125.824
#93	GABPB1	21	12	33	985.587
#94	RORC	21	8	29	2270.963
#95	SNAI2	21	13	34	1173.551
#96	SMAD9	21	15	36	445.41
#97	IRF8	20	5	25	172.459
#98	STAT4	20	11	31	437.136
#99	HLF	20	13	33	1040.002
#100	BNC1	20	14	34	716.91
#101	HOXA5	20	13	33	243.892
#102	TCF3	20	9	29	256.782
#103	HOXD1	20	16	36	3562.308
#104	CEBPB	20	14	34	13044.352
#105	SPI1	19	10	29	604.811
#106	MEF2D	19	11	30	258.728
#107	MEF2A	19	14	33	433.165
#108	SP1	19	6	25	908.086
#109	ZNF70	19	14	33	3122.449
#110	KLF9	19	18	37	647.257
#111	NFIX	19	15	34	1317.621
#112	NOLC1	19	15	34	1255.877
#113	HMGB1	19	13	32	1650.52
#114	CTNNB1	19	12	31	1167.976
#115	PEG3	19	13	32	879.956
#116	NR4A1	18	3	21	10.878
#117	JDP2	18	13	31	1609.853
#118	EBF1	18	8	26	1178.801
#119	TSC22D1	18	9	27	250.25
#120	IRX1	18	9	27	3957.065
#121	SIX4	18	12	30	509.678
#122	PRRX1	18	11	29	1403.828
#123	LHX2	18	13	31	1811.966
#124	AFF1	18	11	29	1432.038
#125	MAFK	18	16	34	519.461
#126	GAS7	17	9	26	2865.921
#127	HR	17	14	31	1897.092
#128	EN1	17	9	26	3325.22
#129	E2F5	17	12	29	3665.867
#130	CEBPD	17	16	33	3317.345
#131	SOX7	17	18	35	1372.175
#132	ZNF75D	17	10	27	1479.309
#133	AFF4	17	8	25	434.187
#134	STAT5A	17	8	25	242.117
#135	SIN3A	17	10	27	1937.091
#136	FOXD1	17	15	32	3360.38
#137	ATF2	17	8	25	318.004
#138	ZNF639	17	12	29	4916.182
#139	FOXG1	17	4	21	260.83
#140	HNF1B	16	8	24	2227.827
#141	ETV1	16	18	34	2642.236
#142	NR3C1	16	14	30	1767.275
#143	BCL3	16	8	24	794.44
#144	NR2F2	16	11	27	319.365
#145	KLF3	16	12	28	1368.703
#146	FOXP2	16	24	40	7457.098
#147	TCF25	16	11	27	713.911
#148	HES6	16	12	28	2788.349
#149	NR2F6	16	15	31	1905.54
#150	BACH2	16	13	29	875.841
#151	WNT5A	16	21	37	2818.226
#152	TCF7L1	16	17	33	5082.332
#153	HOXB6	15	11	26	2020.462
#154	RUNX2	15	16	31	736.605
#155	ZFPM2	15	12	27	2349.447
#156	HIF1A	15	11	26	674.83
#157	HOXC9	15	9	24	893.473
#158	TBX3	15	19	34	4523.918
#159	TRIM28	15	14	29	644.934
#160	ZIC1	15	9	24	6660.079
#161	FOXC2	15	13	28	3917.657
#162	FOXJ3	15	10	25	1223.613
#163	STAT5B	15	16	31	2410.799
#164	IRF7	15	18	33	8633.855
#165	DMRT2	15	15	30	913.144
#166	ZNF238	15	15	30	5478.783
#167	CREB3L4	15	17	32	2386.958
#168	MZF1	15	13	28	272.003
#169	GTF2IRD1	15	12	27	380.411
#170	SALL1	15	9	24	1421.385
#171	TFEB	15	15	30	990.428
#172	NFIL3	15	9	24	422.618
#173	EPAS1	14	17	31	593.116
#174	PURA	14	10	24	467.205
#175	MECOM	14	16	30	1125.317
#176	ZSCAN16	14	17	31	2173.452
#177	SIX1	14	11	25	189.461
#178	NR4A3	14	8	22	523.899
#179	MYNN	14	5	19	898.568
#180	FOSL1	14	10	24	340.537
#181	PBX1	14	18	32	1819.688
#182	SATB1	14	16	30	1748.759
#183	HOXA11	14	12	26	1018.748
#184	HOXB13	14	16	30	1532.321
#185	SOX4	14	13	27	563.647
#186	PITX2	14	15	29	4151.931
#187	CUX1	14	13	27	1228.102
#188	DLX2	14	9	23	1400.069
#189	SMAD6	14	10	24	165.344
#190	ATF3	14	7	21	187.399
#191	EHF	13	16	29	1298.635
#192	FOXO6	13	13	26	1582.105
#193	MEOX2	13	16	29	6476.035
#194	PPARG	13	17	30	470.642
#195	PAX6	13	20	33	1436.754
#196	GRHL2	13	19	32	1458.364
#197	IRX2	13	19	32	4745.153
#198	C11orf9	13	19	32	511.952
#199	ZNF217	13	15	28	9616.736
#200	CBFA2T3	13	14	27	975.901
#201	TP73	13	19	32	1840.666
#202	MSRB2	13	12	25	856.45
#203	FOXA3	12	13	25	1232.616
#204	RUNX1	12	14	26	1709.639
#205	ETV4	12	16	28	6535.88
#206	CREM	12	9	21	141.186
#207	FOS	12	10	22	942.375
#208	FOSL2	12	11	23	1196.628
#209	RXRA	12	17	29	867.619
#210	ZNF148	12	11	23	1815.712
#211	TARDBP	12	14	26	449.207
#212	PRDM2	12	10	22	2915.454
#213	HOXD10	12	10	22	286.523
#214	ZNF83	12	14	26	1098.258
#215	HOXC13	12	13	25	3176.027
#216	GLIS2	12	12	24	754.14
#217	MAFB	12	18	30	2708.541
#218	PLAG1	12	18	30	1991.852
#219	IKZF1	12	7	19	87.402
#220	TFAM	11	13	24	494.85
#221	ZNF91	11	20	31	1126.77
#222	FOXK1	11	15	26	1331.756
#223	HOXD11	11	13	24	7286.331
#224	ARID4A	11	11	22	644.077
#225	NFATC2	11	7	18	621.181
#226	NFAT5	11	10	21	847.072
#227	LMO4	11	14	25	1120.073
#228	ESR1	11	20	31	12814.047
#229	STAT1	11	17	28	1907.231
#230	BATF3	11	13	24	5690.729
#231	ZSCAN2	11	17	28	3456.548
#232	GLI2	11	14	25	512.871
#233	AEBP1	11	8	19	1164.367
#234	BHLHE40	11	12	23	1689.586
#235	ZNF138	11	10	21	4394.655
#236	ZNF281	11	18	29	1149.47
#237	ZFHX4	10	11	21	475.419
#238	KLF4	10	21	31	842.169
#239	ZNF643	10	15	25	4151.945
#240	PBX3	10	15	25	545.051
#241	HOXC10	10	13	23	1633.3
#242	HEYL	10	18	28	355.007
#243	TBX1	10	15	25	817.485
#244	ELK3	10	16	26	2494.956
#245	TSC22D3	10	13	23	273.776
#246	ALX1	10	7	17	468.27
#247	ZNF438	10	13	23	833.233
#248	RBCK1	10	11	21	480.452
#249	SMAD5	10	17	27	902.973
#250	ZNF274	10	18	28	1236.03
#251	BATF	10	11	21	724.73
#252	MEIS1	10	15	25	1928.681
#253	SOX11	10	10	20	2180.975
#254	NFXL1	10	11	21	1652.989
#255	YEATS4	10	14	24	567.349
#256	STAT6	10	13	23	2255.233
#257	TFAP2C	10	19	29	9279.871
#258	SOX6	10	20	30	933.597
#259	MKX	10	10	20	1368.058
#260	ETS1	10	14	24	1227.442
#261	GATA3	10	19	29	2345.454
#262	KLF10	9	19	28	1163.474
#263	TFCP2	9	14	23	1901.96
#264	ZNF93	9	16	25	2444.361
#265	IRF9	9	5	14	276.537
#266	CSRNP3	9	14	23	1079.141
#267	KLF7	9	14	23	2087.189
#268	ONECUT2	9	13	22	1868.188
#269	CREB3L1	9	16	25	1657.912
#270	JUN	9	12	21	889.166
#271	E2F3	9	9	18	449.193
#272	FOXK2	9	8	17	628.175
#273	HOXB3	9	16	25	1071.41
#274	MSX1	9	20	29	4692.98
#275	HMGB2	9	11	20	480.719
#276	BTG2	9	9	18	354.929
#277	SOX13	9	20	29	1564.954
#278	ZNF207	9	14	23	1551.789
#279	NFE2L2	9	16	25	507.264
#280	ZNF92	9	15	24	2779.942
#281	ZFHX3	9	15	24	1587.913
#282	SCML1	8	16	24	3911.759
#283	HCLS1	8	12	20	946.295
#284	DLX3	8	13	21	1548.583
#285	AHCTF1	8	13	21	2037.546
#286	HSF1	8	18	26	1173.725
#287	BATF2	8	13	21	2133.195
#288	FUBP1	8	14	22	445.636
#289	MSX2	8	16	24	2798.394
#290	HEY1	8	19	27	812.051
#291	NFYA	8	18	26	1261.28
#292	RERE	8	14	22	715.185
#293	BCL11B	8	16	24	371.774
#294	ZBTB38	8	21	29	2308.691
#295	BCL6	8	11	19	432.893
#296	GABPA	8	14	22	1782.66
#297	MAX	8	16	24	1199.597
#298	HOXB2	8	14	22	2889.03
#299	RELB	8	11	19	1431.112
#300	IRX5	8	22	30	1605.415
#301	NPAS2	8	21	29	1167.869
#302	NR4A2	8	11	19	1134.127
#303	ZFP90	8	13	21	1016.653
#304	DMRT1	8	13	21	1128.818
#305	GATAD2B	8	16	24	1258.496
#306	TRPS1	8	13	21	198.987
#307	ATF6	8	14	22	792.338
#308	BACH1	8	7	15	334.764
#309	ZNF33A	8	16	24	775.563
#310	SREBF2	7	16	23	4047.983
#311	EGR1	7	10	17	396.982
#312	SOX9	7	21	28	5156.548
#313	FOXQ1	7	24	31	4898.819
#314	JUND	7	12	19	784.085
#315	RORA	7	20	27	4820.422
#316	ZNF323	7	22	29	3368.611
#317	HOXA3	7	16	23	2444.6
#318	HIC1	7	17	24	1115.55
#319	MEIS2	7	17	24	501.007
#320	NR1H3	7	13	20	1193.921
#321	SMAD3	7	14	21	133.521
#322	FOXL2	7	15	22	4592.193
#323	MESP1	7	15	22	1486.746
#324	KLF11	7	13	20	234.3
#325	ZNF268	7	13	20	704.562
#326	SCAND3	7	16	23	664.883
#327	THRB	7	14	21	327.127
#328	CNOT7	7	21	28	1773.92
#329	ZKSCAN5	7	15	22	1684.137
#330	C2orf3	7	11	18	289.185
#331	CREB3L2	7	18	25	1389.903
#332	PLSCR1	7	17	24	7217.275
#333	LCOR	7	12	19	1908.901
#334	SOX5	7	14	21	310.431
#335	ATF5	6	14	20	660.969
#336	TEAD1	6	12	18	570.699
#337	TSHZ2	6	16	22	730.944
#338	SATB2	6	18	24	1384.635
#339	ZNF131	6	18	24	517.341
#340	VAV1	6	12	18	592.517
#341	HEY2	6	21	27	1202.435
#342	TEAD2	6	17	23	3997.574
#343	C1orf85	6	19	25	1262.212
#344	MGA	6	11	17	139.136
#345	DLX4	6	15	21	1808.341
#346	MBD1	6	17	23	503.514
#347	NKX3-1	6	18	24	886.854
#348	NFYC	6	12	18	668.08
#349	CEBPA	6	18	24	574.05
#350	SPEN	6	14	20	1398.13
#351	TEAD3	6	11	17	118.684
#352	KDM5A	6	16	22	636.949
#353	FOXF2	6	14	20	221.927
#354	NFIB	6	27	33	689.479
#355	ASCL2	6	16	22	4344.414
#356	CCRN4L	6	13	19	2201.394
#357	CBFA2T2	6	15	21	2665.699
#358	IRX3	6	15	21	1605.851
#359	TRIM25	6	15	21	2457.734
#360	ELF1	6	12	18	492.408
#361	RARG	6	15	21	540.303
#362	ZHX2	6	22	28	2837.063
#363	HOXD8	6	12	18	726.694
#364	SOX18	6	16	22	699.953
#365	SIM2	6	13	19	511.179
#366	ESRRG	6	16	22	1355.363
#367	RB1	6	16	22	2566.168
#368	UBN1	6	8	14	2137.777
#369	ZNF85	6	14	20	1189.086
#370	ARX	5	10	15	903.844
#371	MSC	5	15	20	698.896
#372	NR5A2	5	11	16	460.688
#373	ATF1	5	16	21	246.788
#374	ARNT2	5	14	19	1225.684
#375	MAF	5	17	22	2183.341
#376	HOXA9	5	15	20	1002.339
#377	PHF5A	5	17	22	1149.421
#378	SLC30A9	5	14	19	1960.267
#379	EGR3	5	9	14	207.515
#380	PCGF2	5	15	20	221.403
#381	ZKSCAN1	5	15	20	1438.499
#382	IRX4	5	15	20	647.092
#383	ZNF117	5	19	24	3643.734
#384	TP53	5	17	22	4906.034
#385	TFCP2L1	5	28	33	5453.651
#386	PLAGL2	5	14	19	649.43
#387	MYCN	5	15	20	788.581
#388	FOXO1	5	17	22	685.38
#389	ERF	5	12	17	158.732
#390	MYCL1	5	21	26	3600.199
#391	ZRANB2	5	10	15	1298.819
#392	FOXO3	5	9	14	158.199
#393	ZNF256	5	15	20	1787.022
#394	PURB	5	19	24	1691.443
#395	LEF1	5	20	25	1187.575
#396	ZNF174	4	18	22	523.895
#397	TCF4	4	26	30	448.653
#398	VTN	4	15	19	519.659
#399	NFE2	4	12	16	338.229
#400	MLLT10	4	14	18	954.888
#401	CREB5	4	13	17	962.47
#402	KLF15	4	13	17	68.896
#403	HHEX	4	16	20	491.458
#404	AHR	4	16	20	302.693
#405	PRDM1	4	14	18	1742.058
#406	TSHZ1	4	15	19	1561.607
#407	ZNF232	4	15	19	3240.28
#408	TEF	4	18	22	1223.265
#409	SMAD1	4	22	26	353.493
#410	ELF3	4	16	20	2060.929
#411	GTF2H2	4	20	24	2340.902
#412	REL	4	13	17	1113.108
#413	SLC2A4RG	4	17	21	287.503
#414	SIX3	4	4	8	83.634
#415	PKNOX2	4	10	14	97.027
#416	IKZF4	4	19	23	504.224
#417	TAF4B	4	14	18	346.265
#418	PRRX2	4	16	20	561.32
#419	NFATC1	4	15	19	82.798
#420	TEAD4	4	13	17	1080.547
#421	KLF12	4	15	19	1213.092
#422	ZFP36L2	4	16	20	1148.68
#423	NFIC	4	15	19	667.446
#424	PGR	4	12	16	188.548
#425	TAF5	4	12	16	227.224
#426	ARNT	3	14	17	134.004
#427	TCFL5	3	19	22	235.084
#428	SALL2	3	18	21	447.894
#429	LHX8	3	10	13	174.655
#430	PHTF1	3	18	21	552.442
#431	NFKB2	3	13	16	480.204
#432	TGIF1	3	20	23	796.366
#433	TSC22D2	3	18	21	434.167
#434	L3MBTL4	3	21	24	4660.728
#435	TFAP2D	3	11	14	450.022
#436	ETV5	3	16	19	1881.203
#437	SOLH	3	11	14	144.077
#438	BHLHE41	3	15	18	289.446
#439	ZNF165	3	17	20	326.616
#440	ZHX3	3	17	20	2958.012
#441	ARNTL	3	15	18	404.421
#442	SOX8	3	9	12	193.064
#443	RCAN1	3	20	23	734.391
#444	CDKN2A	3	18	21	2135.608
#445	ZNF277	3	16	19	1258.348
#446	GTF2H4	3	13	16	284.388
#447	ASCL1	3	9	12	205.705
#448	MYC	3	22	25	468.647
#449	EOMES	3	14	17	3308.86
#450	HIF3A	3	15	18	286.925
#451	TULP4	3	22	25	2775.048
#452	ISL1	3	15	18	739.951
#453	ZSCAN18	3	19	22	419.988
#454	NR1D2	3	15	18	1012.284
#455	TFDP1	3	19	22	323.533
#456	VDR	3	24	27	688.31
#457	TCF7L2	3	19	22	469.801
#458	SPIB	3	16	19	667.741
#459	FOXL1	3	14	17	271.674
#460	NEUROD1	3	9	12	172.672
#461	ZFP42	3	6	9	786.139
#462	RCOR1	3	21	24	1153.541
#463	XBP1	3	12	15	150.696
#464	LHX6	2	17	19	380.005
#465	WT1	2	19	21	2262.085
#466	ZNF397	2	19	21	514.218
#467	NR0B1	2	10	12	273.126
#468	MXD1	2	14	16	218.16
#469	ETV6	2	16	18	442.699
#470	HES1	2	21	23	145.846
#471	DDIT3	2	20	22	233.879
#472	ATF7	2	21	23	740.534
#473	ELF5	2	23	25	1366.706
#474	TRERF1	2	18	20	3540.779
#475	MEOX1	2	17	19	895.887
#476	FOXJ1	2	13	15	114.221
#477	NFE2L3	2	15	17	48.33
#478	ZFPM1	2	11	13	104.42
#479	RUNX3	2	24	26	213.331
#480	CREB1	2	12	14	99.285
#481	RARB	2	15	17	137.92
#482	IRF5	2	21	23	251.013
#483	EGR2	2	15	17	558.184
#484	CREBZF	2	20	22	748.114
#485	OTX2	2	12	14	221.852
#486	IRF4	1	15	16	46.359
#487	FOXC1	1	17	18	54.326
#488	HIRA	1	13	14	214.511
#489	HMBOX1	1	14	15	59.312
#490	HOXD4	1	11	12	306.626
#491	DBP	1	16	17	22.911
#492	GLIS3	1	22	23	1057.76
#493	SREBF1	1	11	12	47.773
#494	LHX9	1	11	12	15.088
#495	FOXA1	1	24	25	807.802
#496	CTBP1	1	16	17	1669.075
#497	HOXA2	1	17	18	298.876
#498	ZFP36L1	0	17	17	0
#499	LZTS1	0	18	18	0
#500	TWIST2	0	17	17	0