Hub Rank	Node	Children	Parents	Degree	Betweenness
#1	ZFHX4	39	2	41	55.958
#2	ZEB2	36	5	41	361.786
#3	SMAD9	35	5	40	2274.846
#4	C5orf41	34	6	40	2362.49
#5	BHLHE41	34	9	43	1595.264
#6	RUNX1T1	34	0	34	0
#7	IRF3	33	3	36	884.5
#8	TBX15	31	5	36	1104.393
#9	ATF1	30	7	37	1294.547
#10	HOXD8	30	13	43	8185.454
#11	RUNX3	30	0	30	0
#12	EBF1	30	2	32	75.281
#13	ELK3	30	6	36	367.755
#14	FOXO1	30	13	43	706.123
#15	SNAI2	29	8	37	2588.329
#16	ZFPM2	28	0	28	0
#17	TEAD2	28	12	40	3567.349
#18	GABPA	28	4	32	229.995
#19	CREB1	27	4	31	729.435
#20	ARID4A	27	10	37	1491.606
#21	AEBP1	27	6	33	1222.403
#22	KDM5A	27	9	36	1976.719
#23	ETS1	27	9	36	1040.162
#24	ZNF277	26	8	34	1301.055
#25	ZNF41	26	10	36	587.629
#26	FLI1	25	6	31	595.864
#27	CBFA2T2	25	6	31	889.693
#28	ZHX2	25	13	38	1165.171
#29	SP1	24	4	28	401.519
#30	PRRX1	24	2	26	87.597
#31	IKZF1	24	3	27	186.3
#32	NR2F1	24	13	37	2950.474
#33	RUNX2	24	6	30	371.773
#34	MYBL2	24	4	28	1816.083
#35	TSHZ2	23	5	28	407.125
#36	HOXA9	23	7	30	6509.777
#37	RORA	23	7	30	416.701
#38	TWIST2	22	10	32	1019.496
#39	ERG	22	3	25	65.872
#40	HSF1	22	4	26	419.39
#41	C2orf3	22	15	37	2252.517
#42	MEF2C	22	13	35	1137.576
#43	GATAD2A	22	11	33	1411.737
#44	TFAM	22	12	34	1991.089
#45	PEG3	22	13	35	3896.757
#46	PLSCR1	22	8	30	1235.664
#47	TRIM28	22	11	33	2203.388
#48	HOXA3	22	8	30	632.806
#49	ALS2CR8	22	8	30	1123.325
#50	BLZF1	21	11	32	1120.639
#51	MEIS2	21	9	30	495.989
#52	HOXA7	21	2	23	1732.513
#53	ZNF192	21	10	31	1998.933
#54	FOXP2	21	10	31	1437.562
#55	ATF2	21	10	31	750.172
#56	TCF12	21	5	26	1238.83
#57	HSF2	21	11	32	2321.152
#58	ZXDA	21	10	31	1247.879
#59	ZEB1	21	11	32	694.318
#60	GAS7	21	7	28	223.737
#61	NFIX	20	12	32	2234.063
#62	IRF9	20	4	24	235.387
#63	CBFB	20	10	30	1231.854
#64	TBX5	20	4	24	61.363
#65	NFYB	20	5	25	272.951
#66	ZNF238	20	22	42	3044.756
#67	ZNF396	20	9	29	1158.445
#68	ETV1	20	10	30	2181.56
#69	FOXN2	20	11	31	1166.196
#70	ZNF131	20	10	30	1798.863
#71	GLIS3	20	6	26	619.48
#72	SOX17	20	6	26	265.661
#73	HCLS1	19	8	27	1843.298
#74	SMAD4	19	10	29	1365.273
#75	E2F8	19	6	25	547.156
#76	E2F5	19	9	28	1893.159
#77	TRIM22	19	7	26	655.141
#78	PTTG1	19	5	24	484.084
#79	TGIF1	19	7	26	436.312
#80	TFAP2A	19	11	30	1152.656
#81	TGIF2	19	10	29	1045.194
#82	CREM	18	9	27	2394.05
#83	IRF8	18	4	22	1241.979
#84	SLC2A4RG	18	6	24	685.683
#85	SP140	18	7	25	1315.599
#86	WNT5A	18	12	30	806.259
#87	RBCK1	18	10	28	1227.998
#88	JUNB	18	4	22	1124.152
#89	NPAT	18	9	27	713.573
#90	ZKSCAN1	17	11	28	1294.671
#91	HOXA10	17	6	23	1545.543
#92	KLF6	17	11	28	1478.948
#93	MZF1	17	9	26	787.38
#94	TFEC	17	9	26	584.722
#95	CREB5	17	15	32	884.807
#96	TP53	17	14	31	2832.555
#97	SALL1	17	7	24	238.717
#98	ZSCAN16	17	15	32	2218.852
#99	MEIS3P1	17	10	27	1060.4
#100	MAFB	17	6	23	208.75
#101	RORC	17	14	31	1788.14
#102	FOXN3	17	11	28	1398.913
#103	MECOM	17	8	25	747.443
#104	HMGA1	17	13	30	2008.546
#105	ZNF18	17	9	26	2314.923
#106	BACH1	16	13	29	2175.564
#107	IRX1	16	12	28	705.996
#108	BCL11B	16	7	23	463.465
#109	MAF	16	7	23	1229.915
#110	HOXA5	16	8	24	3706.411
#111	TRPS1	16	11	27	1090.293
#112	ZNF207	16	20	36	4825.776
#113	TSHZ3	16	7	23	330.599
#114	ZNF167	16	11	27	1836.836
#115	PRDM1	16	12	28	727.688
#116	MEF2A	16	4	20	596.464
#117	FOXO3	16	15	31	2459.889
#118	ZNF287	16	18	34	1491.976
#119	NR2F6	16	12	28	1184.356
#120	SMAD3	16	11	27	1968.058
#121	LZTS1	16	14	30	1137.179
#122	MSRB2	16	9	25	1134.188
#123	SPI1	16	12	28	2065.687
#124	MTF1	16	17	33	3330.326
#125	NFIC	16	7	23	1221.757
#126	FOXM1	15	3	18	539.281
#127	ESR1	15	18	33	1181.149
#128	NFATC1	15	10	25	1252.904
#129	ZNF500	15	10	25	1561.341
#130	KLF9	15	11	26	1003.779
#131	EHF	15	13	28	988.177
#132	CUX1	15	8	23	1527.062
#133	FOSB	15	1	16	173.447
#134	SCAND1	15	7	22	1545.984
#135	SOX13	15	12	27	1014.221
#136	DRAP1	15	13	28	1864.5
#137	MAX	15	5	20	439.16
#138	SOX7	15	5	20	228.763
#139	FOXK2	15	12	27	1791.251
#140	BTG2	15	11	26	1886.451
#141	KDM5B	15	10	25	1261.502
#142	ZNF45	15	7	22	659.633
#143	YEATS4	15	9	24	933.183
#144	AFF4	14	6	20	657.319
#145	GLI3	14	16	30	1692.81
#146	PRDM2	14	11	25	508.757
#147	HIC1	14	12	26	1157.101
#148	HDX	14	13	27	1536.807
#149	TAF4B	14	16	30	2787.708
#150	UHRF1	14	8	22	1087.089
#151	SMAD1	14	12	26	1804.813
#152	ZNF93	14	11	25	1336.853
#153	NR3C2	14	11	25	1531.654
#154	TWIST1	14	13	27	605.536
#155	SIM1	14	13	27	1689.833
#156	CREBL2	14	13	27	1058.628
#157	IRF2	14	10	24	1238.755
#158	TCF7L2	14	9	23	599.377
#159	BRD8	14	8	22	1608.886
#160	NOLC1	14	8	22	786.474
#161	MEOX2	14	8	22	1001.387
#162	STAT2	14	6	20	453.129
#163	ZNF138	14	17	31	2139.326
#164	SUPT4H1	14	11	25	1888.071
#165	GRHL2	14	13	27	1065.796
#166	TFCP2	14	11	25	1558.355
#167	SPDEF	14	12	26	1409.202
#168	MSX1	14	8	22	1337.223
#169	NFIB	14	17	31	1219.946
#170	ZC3H8	13	10	23	910.361
#171	CSRNP3	13	14	27	2388.969
#172	TCF4	13	10	23	320.63
#173	SATB1	13	13	26	2854.837
#174	AHR	13	15	28	1769.72
#175	NANOG	13	18	31	3283.401
#176	FOXP1	13	12	25	1016.435
#177	HMGB2	13	8	21	1365.161
#178	MYT1	13	13	26	1431.371
#179	HOXA2	13	13	26	2132.015
#180	CREBZF	13	12	25	1950.956
#181	IRF4	13	13	26	4795.042
#182	MYC	13	13	26	1077.299
#183	RARA	13	10	23	2185.598
#184	ETS2	13	9	22	1059.312
#185	TEAD4	13	10	23	1690.954
#186	SCML1	13	15	28	2685.349
#187	GLI2	13	4	17	23.114
#188	FOXD1	13	8	21	968.694
#189	NFE2L2	13	11	24	2770.789
#190	ZNF323	13	14	27	2169.274
#191	TEAD1	12	12	24	1036.572
#192	ZNF367	12	8	20	1108.591
#193	SCML2	12	5	17	395.575
#194	FOXQ1	12	9	21	886.384
#195	TARDBP	12	9	21	737.37
#196	EPAS1	12	9	21	795.264
#197	NFYA	12	9	21	827.322
#198	ZNF193	12	8	20	2029.735
#199	REL	12	14	26	2299.339
#200	HOXB7	12	14	26	1432.782
#201	MLL	12	12	24	1904.556
#202	ZHX3	12	10	22	1407.9
#203	ETV5	12	12	24	1859.602
#204	SREBF1	12	12	24	1351.339
#205	GATAD2B	12	10	22	1828.036
#206	NANOGNB	12	14	26	1265.395
#207	HOPX	12	15	27	1155.135
#208	MEIS1	12	12	24	1087.619
#209	ETV7	12	6	18	459.448
#210	TAF5L	12	12	24	1261.476
#211	HHEX	12	23	35	1709.92
#212	ZNF256	12	9	21	655.295
#213	KLF3	12	13	25	866.521
#214	CREB3L1	12	18	30	2059.935
#215	YBX1	12	11	23	1421.849
#216	NR1D2	12	11	23	1618.356
#217	SMAD6	11	15	26	1663.265
#218	TCF3	11	13	24	1179.919
#219	IRF7	11	8	19	651.787
#220	NR3C1	11	10	21	660.392
#221	AR	11	12	23	1498.685
#222	ZHX1	11	16	27	1371.453
#223	ZNF397	11	14	25	1342.817
#224	TAF13	11	9	20	1519.474
#225	RELB	11	9	20	1026.767
#226	NFIA	11	18	29	2341.802
#227	JUN	11	7	18	655.765
#228	RUNX1	11	13	24	1044.58
#229	GLIS2	11	6	17	63.083
#230	FOS	11	4	15	320.884
#231	PITX2	11	10	21	657.583
#232	TSHZ1	11	9	20	774.675
#233	FOXK1	11	10	21	583.242
#234	GTF2I	11	11	22	1161.464
#235	KLF7	11	14	25	1070.039
#236	JUND	11	12	23	1372.838
#237	TFDP2	11	12	23	4370.449
#238	HLF	11	19	30	2875.934
#239	NFX1	11	8	19	1053.8
#240	EGR2	11	8	19	490.962
#241	ZNF643	11	14	25	1855.492
#242	ZNF281	11	7	18	796.816
#243	PA2G4	11	9	20	1954.555
#244	STAT4	11	8	19	346.169
#245	CCRN4L	11	14	25	1421.399
#246	ZNF236	10	10	20	349.984
#247	PBX1	10	10	20	728.561
#248	ATF3	10	11	21	608.571
#249	KLF12	10	16	26	1381.897
#250	PLAG1	10	8	18	410.731
#251	HIF1A	10	10	20	613.512
#252	CITED2	10	9	19	1062.433
#253	ZNF148	10	13	23	1446.654
#254	AHCTF1	10	13	23	1815.66
#255	TBX1	10	16	26	1580.615
#256	HOXC11	10	11	21	1939.788
#257	ENO1	10	13	23	1213.262
#258	CREBBP	10	11	21	1404.808
#259	SMAD5	10	10	20	1122.615
#260	MLLT10	10	16	26	2173.681
#261	DBP	10	9	19	596.331
#262	PAX6	10	9	19	755.189
#263	NFATC4	10	12	22	1385.859
#264	HOXC4	10	10	20	1321.051
#265	SOX11	10	20	30	5143.539
#266	NFATC2	10	10	20	406.096
#267	ONECUT2	10	9	19	982.909
#268	ZNF639	10	11	21	829.521
#269	SOX4	10	14	24	1028.37
#270	CEBPD	10	15	25	1360.372
#271	EN1	10	11	21	1333.137
#272	C1orf85	10	12	22	1428.95
#273	E2F7	9	13	22	821.213
#274	CREB3	9	9	18	937.147
#275	BACH2	9	17	26	1177.841
#276	BATF	9	10	19	888.232
#277	MXD1	9	17	26	2967.5
#278	CBFA2T3	9	20	29	1938.484
#279	ZFP37	9	16	25	900.486
#280	MITF	9	12	21	225.825
#281	TULP4	9	18	27	1491.335
#282	ZNF134	9	13	22	587.41
#283	ZFP36L1	9	13	22	801.729
#284	KLF2	9	12	21	1221.268
#285	ZFP36L2	9	11	20	2267.545
#286	HOXD1	9	16	25	1134.109
#287	SLC26A3	9	16	25	2063.625
#288	FOXJ3	9	7	16	547.169
#289	ZNF83	9	6	15	786.669
#290	TBX3	9	13	22	941.885
#291	NFYC	9	14	23	1154.378
#292	CITED1	9	11	20	1124.87
#293	NCOR1	9	10	19	728.449
#294	SATB2	9	16	25	1504.607
#295	TCF19	9	4	13	188.122
#296	ANKRD30A	9	23	32	1696.347
#297	CBL	9	11	20	870.879
#298	PITX1	9	17	26	1811.883
#299	SPEN	9	8	17	575.439
#300	RCAN1	9	15	24	1321.39
#301	HOXB4	9	7	16	677.487
#302	CEBPB	9	14	23	902.269
#303	JDP2	9	12	21	2424.518
#304	NR2C1	9	12	21	1212.317
#305	SIX4	8	19	27	988.861
#306	FOXC2	8	9	17	1372.865
#307	NR4A1	8	7	15	378.607
#308	ZNF91	8	19	27	2008.376
#309	TFAP2C	8	20	28	1692.111
#310	BCL3	8	12	20	577.916
#311	GTF2H2	8	20	28	1453.199
#312	EOMES	8	5	13	246.311
#313	DMRT2	8	11	19	522.309
#314	GATA3	8	16	24	932.704
#315	TFDP1	8	13	21	1331.46
#316	ARNTL2	8	12	20	1453.572
#317	HEY2	8	17	25	1086.036
#318	VDR	8	9	17	484.519
#319	LASS6	8	12	20	406.661
#320	HES6	8	9	17	773.434
#321	PAX7	8	10	18	1108.856
#322	MEOX1	8	20	28	1419.025
#323	ZNF217	8	17	25	1691.158
#324	HOXC13	8	16	24	727.149
#325	FOXF2	8	13	21	625.432
#326	HOXC10	8	12	20	788.102
#327	UBN1	8	12	20	702.05
#328	NR5A2	8	12	20	769.242
#329	ATF6	8	18	26	1569.118
#330	TCF7L1	8	12	20	261.973
#331	FUBP1	8	10	18	695.565
#332	ELF4	8	12	20	479.539
#333	NR2F2	8	19	27	1270.078
#334	GABPB1	8	15	23	1189.568
#335	ZNF232	8	11	19	947.892
#336	SOX5	8	7	15	1410.062
#337	BATF2	8	12	20	682.469
#338	ESRRG	8	24	32	1490.841
#339	TCEAL1	8	11	19	793.987
#340	STAT1	8	10	18	516.172
#341	RARB	8	11	19	1175.862
#342	SLC30A9	8	17	25	963.024
#343	C12orf28	8	14	22	1925.081
#344	PPARA	8	9	17	476.804
#345	GSC	8	10	18	966.152
#346	FOSL2	7	20	27	1342.793
#347	NR2E3	7	13	20	924.175
#348	ARNTL	7	18	25	1997.49
#349	CNOT7	7	15	22	693.719
#350	TP63	7	12	19	808.685
#351	PGBD1	7	16	23	2393.887
#352	ISL1	7	9	16	838.518
#353	EGR3	7	13	20	487.122
#354	MYNN	7	14	21	859.698
#355	CEBPA	7	12	19	1675.084
#356	SALL2	7	15	22	1183.331
#357	MTA1	7	17	24	1257.249
#358	THRA	7	11	18	873.872
#359	CSRNP1	7	8	15	349.756
#360	ZNF140	7	13	20	775.795
#361	NFE2L3	7	17	24	1502.576
#362	ZNF165	7	14	21	2185.098
#363	HOXB13	7	19	26	1455.995
#364	NR4A2	7	14	21	729.248
#365	KLF5	7	17	24	814.734
#366	LEF1	7	13	20	2009.262
#367	ZRANB2	7	11	18	298.845
#368	SIM2	7	13	20	900.308
#369	HOXB5	7	3	10	192.417
#370	HOXC9	6	10	16	430.633
#371	IRX5	6	13	19	7036.321
#372	ZSCAN18	6	16	22	973.4
#373	MMP14	6	14	20	586.079
#374	TRERF1	6	15	21	1237.741
#375	KLF4	6	19	25	1070.378
#376	ARNT2	6	20	26	819.074
#377	LMO4	6	17	23	962.667
#378	CREB3L2	6	16	22	1849.294
#379	RFX3	6	10	16	361.95
#380	LCOR	6	16	22	1251.266
#381	HOXB3	6	11	17	895.293
#382	XBP1	6	12	18	526.931
#383	EGR1	6	9	15	748.735
#384	ELF5	6	17	23	2067.089
#385	FOXP4	6	12	18	235.867
#386	NKX3-2	6	11	17	386.267
#387	LASS2	6	10	16	497.877
#388	NKX3-1	6	26	32	1936.129
#389	ZFHX3	6	21	27	1886.486
#390	SOX10	6	11	17	1121.559
#391	HOXD10	6	10	16	347.773
#392	ATF5	6	11	17	468.452
#393	LHX8	6	6	12	295.282
#394	THRB	6	13	19	522.869
#395	ZNF92	6	14	20	892.71
#396	ZNF135	6	13	19	1213.557
#397	ZNF70	5	14	19	974.529
#398	HES1	5	12	17	997.24
#399	BCL6	5	15	20	1214.171
#400	PPARD	5	19	24	928.333
#401	IRX3	5	6	11	653.801
#402	TCFL5	5	13	18	889.737
#403	MESP1	5	8	13	329.071
#404	HOXB2	5	16	21	1274.092
#405	WT1	5	23	28	922.115
#406	NR4A3	5	11	16	831.675
#407	HESX1	5	10	15	395.945
#408	LHX9	5	7	12	1417.661
#409	ASCL2	5	16	21	928.232
#410	SIX3	5	8	13	732.222
#411	STAT5B	5	11	16	534.105
#412	HEYL	5	12	17	453.163
#413	SOX9	5	22	27	1106.26
#414	E2F3	5	16	21	940.809
#415	ARNT	5	17	22	979.487
#416	RFXAP	5	15	20	827.217
#417	BHLHE40	5	18	23	1542.943
#418	IRF1	5	13	18	634.844
#419	HMG20B	5	15	20	600.249
#420	TEF	5	12	17	883.822
#421	GATA6	5	14	19	330.629
#422	HOXB8	5	12	17	676.646
#423	GATA4	5	7	12	1329.821
#424	PGR	5	21	26	1668.639
#425	STRN3	5	11	16	1064.847
#426	ZNF33B	5	16	21	808.867
#427	PURB	5	11	16	466.142
#428	HOXD4	5	13	18	598.566
#429	TFCP2L1	5	20	25	781.932
#430	HMBOX1	5	16	21	1102.968
#431	MAFF	5	18	23	1270.89
#432	NR1H3	5	10	15	326.804
#433	MSX2	5	22	27	1555.492
#434	NFIL3	5	13	18	794.258
#435	ARX	5	14	19	3198.183
#436	HOXB6	4	15	19	1065.591
#437	TSC22D3	4	11	15	578.346
#438	SOX2	4	13	17	476.183
#439	USF1	4	11	15	1436.809
#440	SIX1	4	21	25	642.065
#441	CDKN2A	4	14	18	357.289
#442	DLX1	4	11	15	537.426
#443	ZIC2	4	15	19	778.795
#444	MYCN	4	15	19	654.149
#445	FOXA3	4	4	8	229.407
#446	PPARG	4	13	17	172.078
#447	SOLH	4	15	19	352.676
#448	ZNF24	4	13	17	243.24
#449	LHX6	4	14	18	400.238
#450	SP3	4	10	14	522.576
#451	IRF6	4	16	20	488.011
#452	CREB3L4	4	19	23	792.373
#453	ZSCAN5A	4	10	14	1007.883
#454	TSC22D1	4	14	18	679.796
#455	PCGF2	4	10	14	234.355
#456	CTBP1	4	12	16	687.718
#457	MKX	4	15	19	1781.066
#458	MYCL1	4	14	18	720.424
#459	DLX2	4	14	18	1857.555
#460	GATA2	4	15	19	560.031
#461	POU2F3	4	14	18	675.138
#462	NFATC3	4	16	20	350.686
#463	ZNF85	4	21	25	867.889
#464	CTNNB1	4	15	19	1010.564
#465	ZSCAN12	4	13	17	400.115
#466	ASCL1	4	22	26	1097.64
#467	SOX18	4	8	12	271.245
#468	NR0B1	3	6	9	131.018
#469	ETV6	3	16	19	282.414
#470	SIX2	3	15	18	223.172
#471	TFAP2B	3	31	34	771.718
#472	ATF7	3	14	17	325.863
#473	NPAS2	3	18	21	559.432
#474	SP4	3	13	16	377.144
#475	FOXC1	3	9	12	283.662
#476	TRIM29	3	12	15	183.721
#477	ZNF174	3	15	18	200.405
#478	ZIC1	3	14	17	1284.247
#479	NFAT5	3	14	17	595.189
#480	ZNF274	3	9	12	305.455
#481	TRIM25	3	15	18	1039.529
#482	ZNF132	3	13	16	472.919
#483	PBX3	3	16	19	1267.856
#484	OVOL1	3	13	16	290.001
#485	FOXA1	3	18	21	406.477
#486	ZNF268	3	16	19	574.627
#487	CSDA	3	11	14	685.445
#488	IRF5	3	12	15	257.765
#489	IRX2	2	19	21	138.696
#490	HEY1	2	11	13	195.315
#491	ELF3	2	15	17	684.317
#492	MGA	2	12	14	201.592
#493	FOXI1	2	16	18	311.387
#494	SCAND3	2	13	15	131.678
#495	RERE	2	19	21	488.47
#496	CUX2	2	12	14	839.976
#497	SOX6	2	19	21	244.666
#498	HNF4G	2	12	14	165.651
#499	ZNF117	1	16	17	470.741
#500	IRX4	0	16	16	0